SUMMARY OBJECTIVE: The aim of our study was to determine the role of serum glucose–potassium ratio in predicting inhospital mortality in coronary care unit patients. METHODS: This study used data from the MORtality in CORonary Care Units in Turkey study, a national, observational, multicenter study that included all patients admitted to coronary care units between September 1, 2022, and September 30, 2022. Statistical analyses assessed the independent predictors of mortality. Two models were created. Model 1 included age, history of heart failure, chronic kidney disease, hypertension, diabetes mellitus, and coronary artery disease. Model 2 included glucose–potassium ratio in addition to these variables. Multivariate regression and receiver operating characteristic analysis were performed to compare Model 1 and Model 2 to identify if the glucose–potassium ratio is an independent predictor of inhospital mortality. RESULTS: In a study of 3,157 patients, the mortality rate was 4.3% (n=137). Age (p=0.002), female gender (p=0.004), mean blood pressure (p<0.001), serum creatinine (p<0.001), C-reactive protein (p=0.002), white blood cell (p=0.002), and glucose–potassium ratio (p<0.001) were identified as independent predictors of mortality through multivariate regression analysis. The receiver operating characteristic analysis indicated that Model 2 had a statistically higher area under the curve than Model 1 (area under the curve 0.842 vs area under the curve 0.835; p<0.001). A statistically significant correlation was found between the inhospital mortality and glucose–potassium ratio (OR 1.015, 95%CI 1.006–1.024, p<0.001). CONCLUSION: Our study showed that the glucose–potassium ratio may be a significant predictor of inhospital mortality in coronary care unit patients. OBJECTIVE glucosepotassium glucose potassium METHODS national observational 2022 30 created age failure disease hypertension mellitus variables RESULTS 3157 3 157 3,15 43 4 4.3 n=137. n137 n n=137 . 137 (n=137) p=0.002, p0002 p p=0.002 , 0 002 (p=0.002) p=0.004, p0004 p=0.004 004 (p=0.004) p<0.001, p0001 p<0.001 001 Creactive C reactive (p<0.001 0842 842 0.84 0.835 0835 835 p<0.001. p<0.001) OR 1015 015 1.015 95CI CI 95 10061024 006 024 1.006–1.024 CONCLUSION 202 315 15 3,1 4. n13 n=13 13 (n=137 p000 p=0.00 00 (p=0.002 (p=0.004 p<0.00 (p<0.00 084 84 0.8 0.83 083 83 101 01 1.01 9 1006102 02 1.006–1.02 20 31 3, n1 n=1 (n=13 p00 p=0.0 (p=0.00 p<0.0 (p<0.0 08 8 0. 10 1.0 100610 1.006–1.0 n= (n=1 p0 p=0. (p=0.0 p<0. (p<0. 1. 10061 1.006–1. (n= p=0 (p=0. p<0 (p<0 1006 1.006–1 (n p= (p=0 p< (p< 100 1.006– (p= (p 1.006 1.00

SUMMARY OBJECTIVE: The objective of this study was to investigate serum Metrnl levels in pregnant women with gestational diabetes mellitus and compare them with pregnant women without gestational diabetes mellitus. METHODS: The gestational diabetes mellitus group consisted of 87 pregnant women diagnosed with gestational diabetes mellitus, and the control group consisted of 93 healthy pregnant women without gestational diabetes mellitus. Serum Metrnl levels were determined by the enzyme-linked immunosorbent assay method. RESULTS: The two groups were similar in terms of demographic features. The median serum Metrnl level was found to be 1.16 ng/mL in the gestational diabetes mellitus group, while it was determined as 2.2 ng/mL in the control group (p=0.001). The two groups were divided into two subgroups based on participants’ body mass index, normal weight and overweight. The lowest median Metrnl level was detected in the normal weight gestational diabetes mellitus group, followed by the overweight gestational diabetes mellitus group, normal weight control group, and overweight control group (1.1, 1.2, 2, and 2.4 ng/mL, respectively). Receiver operating curve analysis was performed to determine the value of the serum Metrnl level in terms of predicting gestational diabetes mellitus. The area under the curve analysis of serum Metrnl for gestational diabetes mellitus estimation was 0.768 (p=0.000, 95%CI 0.698–0.839). The optimal cutoff value for serum Metrnl level was determined as 1.53 ng/mL with 69% sensitivity and 70% specificity. CONCLUSION: Serum Metrnl levels in pregnant women with gestational diabetes mellitus were found to be significantly lower than in pregnant women without gestational diabetes mellitus. The mechanisms underlying the decrease in serum Metrnl levels in gestational diabetes mellitus remain unclear for now, and future studies will reveal the role of Metrnl in the pathophysiology of gestational diabetes mellitus. OBJECTIVE METHODS 8 9 enzymelinked enzyme linked method RESULTS features 116 1 16 1.1 ngmL ng mL 22 2 2. p=0.001. p0001 p p=0.001 . 0 001 (p=0.001) participants index 1.1, 11 (1.1 12 1.2 24 4 respectively. respectively respectively) 0768 768 0.76 p=0.000, p0000 000 (p=0.000 95CI CI 95 0.698–0.839. 06980839 0.698–0.839 698 839 0.698–0.839) 153 53 1.5 69 70 specificity CONCLUSION now 1. p000 p=0.00 00 (p=0.001 (1. 076 76 0.7 p=0.000 (p=0.00 0698083 0.698–0.83 83 15 5 6 7 p00 p=0.0 (1 07 0. (p=0.0 069808 0.698–0.8 p0 p=0. ( (p=0. 06980 0.698–0. p=0 (p=0 0698 0.698–0 p= (p= 069 0.698– (p 06 0.698 0.69 0.6

SUMMARY OBJECTIVE: Phyllodes tumors in the breast are exceptionally uncommon fibroepithelial tumors. In the literature, they are typically categorized as benign phyllodes tumor, borderline phyllodes tumor, and malignant phyllodes tumor. This study aims to assess and present the clinical and surgical outcomes of patients diagnosed with phyllodes tumor. METHODS: The outcomes of patients aged 18 years and above diagnosed with phyllodes tumor between 2006 and 2023 were retrospectively reviewed. Patients were grouped as benign phyllodes tumor and borderline/malignant phyllodes tumor and compared by clinical and surgical results. RESULTS: Of all 57 patients with phyllodes tumor, 64.9% (n=37) were benign phyllodes tumor and 35.1% (n=20) were borderline/malignant phyllodes tumor [22.8% (n=13) borderline phyllodes tumor and 12.3% (n=7) malignant phyllodes tumor]. When the patients were divided into two groups as benign phyllodes tumor and borderline/malignant phyllodes tumor and compared, our cumulative (total) recurrence rate was 14.0%, with final surgical margin width between groups [(0<final surgical margin<2 mm vs final surgical margin≥2 mm) (p=0.154)] and recurrence [(8.1% benign phyllodes tumor vs 25.0% borderline/malignant phyllodes tumor) (p=0.080)]; there was no significant difference between our rates. CONCLUSION: Phyllodes tumors of the breast can be followed up with a narrow negative surgical margin (0 mm<final surgical margin<2 mm). However, after the initial surgery, re-excision is recommended for positive margins, while a wider surgical margin (≥10 mm) is not necessary for excision. OBJECTIVE literature METHODS 1 200 202 reviewed borderlinemalignant results RESULTS 5 649 64 9 64.9 n=37 n37 n 37 (n=37 351 35 35.1 n=20 n20 20 (n=20 22.8% 228 22 8 [22.8 n=13 n13 13 (n=13 123 12 3 12.3 n=7 n7 7 (n=7 . tumor] total (total 140 14 0 14.0% 0<final 0final margin2 2 margin< margin≥ p=0.154 p0154 p 154 (p=0.154) 8.1% 81 [(8.1 250 25 25.0 p=0.080 p0080 080 (p=0.080)] rates CONCLUSION ( mmfinal mm. However surgery reexcision re excision margins ≥10 10 (≥1 6 64. n=3 n3 (n=3 35. n=2 n2 (n=2 22.8 [22. n=1 n1 (n=1 12. n= (n= 14.0 p=0.15 p015 15 (p=0.154 8.1 [(8. 25. p=0.08 p008 08 (p=0.080) ≥1 (≥ 22. [22 (n 14. p=0.1 p01 (p=0.15 8. [(8 p=0.0 p00 (p=0.080 ≥ [2 p=0. p0 (p=0.1 [( (p=0.08 [ p=0 (p=0. (p=0.0 p= (p=0 (p= (p

SUMMARY OBJECTIVE: This study was conducted to determine the relationship between bone mineral density, vitamin D level, and sleep quality in female patients with osteoporosis. METHODS: This descriptive correlational study included a total of 318 women diagnosed with osteoporosis. The data were collected using a patient identification form, including items for the plasma vitamin D level and bone mineral density score obtained by the dual-energy X-ray absorptiometry method, and the Pittsburgh Sleep Quality Index. RESULTS: The mean age of the women was 56.49±5.68 years, and their femoral neck T mean score, an indicator of bone mineral density, was −2.94±0.31. Only 6.3% of the women had adequate vitamin D levels. In addition, according to their Pittsburgh Sleep Quality Index scores, 85.8% of the women had poor sleep quality. In the study, no significant difference was found between the women's bone mineral densities and vitamin D levels according to sleep quality (p>0.05). However, there was a weak negative correlation between the duration of osteoporosis, body mass index, and sleep quality (p<0.05). CONCLUSION: There was no association between the vitamin D level, bone mineral density, and sleep quality, but the duration of osteoporosis was negatively associated with sleep quality. Accordingly, it may be recommended to provide education and counseling to postmenopausal women diagnosed with osteoporosis on issues such as sunbathing, vitamin D and calcium preparation intake, weight control, and non-pharmacological treatment approaches by making necessary individual-specific plans to improve sleep quality. OBJECTIVE METHODS 31 form dualenergy dual energy Xray X ray method RESULTS 5649568 56 49 5 68 56.49±5.6 years 294031 2 94 0 −2.94±0.31 63 6 3 6.3 addition scores 858 85 8 85.8 womens s p>0.05. p005 p p>0.05 . 05 (p>0.05) However index p<0.05. p<0.05 (p<0.05) CONCLUSION Accordingly sunbathing intake control nonpharmacological non pharmacological individualspecific individual specific 564956 4 56.49±5. 29403 9 −2.94±0.3 6. 85. p00 p>0.0 (p>0.05 p<0.0 (p<0.05 56495 56.49±5 2940 −2.94±0. p0 p>0. (p>0.0 p<0. (p<0.0 5649 56.49± 294 −2.94±0 p>0 (p>0. p<0 (p<0. 564 56.49 29 −2.94± p> (p>0 p< (p<0 56.4 −2.94 (p> (p< 56. −2.9 (p −2. −2 −

SUMMARY OBJECTIVE: February 2023 saw major earthquakes in Pazarcık and Elbistan, causing significant devastation in Turkey. Patients were transferred to hospitals in neighboring provinces, with multiple traumas—especially fractures and organ injuries—forming the main reasons for hospital admissions. This study aimed to examine earthquake-related injuries in pediatric and adult populations to understand differences. METHODS: This study analyzed 1,220 adults and 590 pediatric patients with radiological imaging out of 8,704 earthquake trauma cases. Radiological images were assessed independently by two radiologists. Statistical analysis using SPSS examined relationships between variables such as age group and injury type. RESULTS: Results showed 40% of adults and 64% of children had normal radiological findings. Cerebral and extremity traumas were most common in pediatrics, while adults showed more extremity, thoracic, and spinal traumas. Significant differences between adult and pediatric groups were observed in cranial fractures, thoracic and lumbar vertebral fractures, hemopneumothorax, lung contusions, rib fractures, femur and talocalcaneal fractures, and compartment syndrome (p<0.001). CONCLUSION: Earthquake-related injuries may vary between children and adults. Due to children's more flexible anatomical structure, it is believed that earthquake-related injuries occur less frequently in children. In this study, head traumas were more common in children compared to adults. The rate of cranial fractures was significantly higher in children, with a higher incidence of epidural hematoma compared to adults. Spinal traumas were more frequent in adults than in children, attributed to children's greater flexibility reducing the risk of entrapment under rubble. Pediatric thoracic compliance being significantly higher than in adults often resulted in milder chest traumas. However, compartment syndrome was more common in children, with a lower rate of accompanying bone fractures compared to adults. No significant difference was observed between children and adults in maxillofacial, abdominal, and pelvic traumas. These findings provide insights for future disaster healthcare planning and management. OBJECTIVE 202 Elbistan Turkey provinces traumasespecially especially injuriesforming forming admissions earthquakerelated related METHODS 1220 1 220 1,22 59 8704 8 704 8,70 cases radiologists type RESULTS 40 64 pediatrics hemopneumothorax contusions p<0.001. p0001 p p<0.001 . 0 001 (p<0.001) CONCLUSION Earthquakerelated Earthquake childrens s structure rubble However maxillofacial abdominal management 20 122 22 1,2 5 870 70 8,7 4 6 p000 p<0.00 00 (p<0.001 2 12 1, 87 7 8, p00 p<0.0 (p<0.00 p0 p<0. (p<0.0 p<0 (p<0. p< (p<0 (p< (p

SUMMARY BACKGROUND: Cancer-related fatigue is a pervasive symptom, affecting up to 90% of cancer patients throughout their illness, and can persist well after treatment has ended. Despite its prevalence, no definitive evidence-based treatment exists, leading to an abundance of proposed alternatives, including natural supplements. To further explore the potential effects of guaraná on cancer-related fatigue, a systematic review with meta-analysis was conducted and registered on the International Prospective Register of Systematic Reviews (CRD42023484144). METHODS: A thorough search of PubMed/MEDLINE and Cochrane Library was conducted using MeSH terms and related keywords for cancer-related fatigue and guaraná. Eligible studies were selected according to predetermined criteria and assessed for quality in accordance with the Cochrane Handbook for Systematic Reviews of Interventions. Data extraction was independently performed by two reviewers, with any discrepancies resolved by a third researcher. RESULTS: In total, 4 full articles and 1 abstract, encompassing a total of 229 patients from 2009 to 2023, were included in the meta-analysis. Despite high heterogeneity between studies (I2=78%, ꭓ2=18.51, df=4, p=0.0010), the analysis revealed a significant benefit of using guaraná to alleviate cancer-related fatigue, with a standard mean difference of −0.77 (95%CI −1.34, −0.21) and a test for the overall effect of Z=2.68 (p=0.007). CONCLUSION: This meta-analysis provides support for the use of guaraná in the treatment of cancer-related fatigue. However, further investigation through larger prospective randomized controlled trials is necessary to validate these findings. BACKGROUND Cancerrelated Cancer symptom 90 illness ended prevalence evidencebased evidence based exists alternatives supplements cancerrelated metaanalysis meta CRD42023484144. CRD42023484144 CRD . (CRD42023484144) METHODS PubMedMEDLINE PubMed MEDLINE Interventions reviewers researcher RESULTS abstract 22 200 2023 metaanalysis. analysis. I2=78%, I278 I I2 78 (I2=78% ꭓ21851 ꭓ ꭓ2 18 51 ꭓ2=18.51 df4 df df=4 p=0.0010, p00010 p p=0.0010 , 0 0010 p=0.0010) 077 77 −0.7 95%CI 95CI CI 95 134 34 −1.34 −0.21 021 21 Z268 Z 2 68 Z=2.6 p=0.007. p0007 p=0.007 007 (p=0.007) CONCLUSION However findings 9 CRD4202348414 (CRD42023484144 20 202 I2=78% I27 7 (I2=78 ꭓ2185 5 ꭓ2=18.5 df= p0001 p=0.001 001 07 −0. 13 3 −1.3 −0.2 02 Z26 6 Z=2. p000 p=0.00 00 (p=0.007 CRD420234841 (CRD4202348414 I2=78 (I2=7 ꭓ218 ꭓ2=18. −0 −1. Z2 Z=2 p00 p=0.0 (p=0.00 CRD42023484 (CRD420234841 I2=7 (I2= ꭓ21 ꭓ2=18 − −1 Z= p0 p=0. (p=0.0 CRD4202348 (CRD42023484 I2= (I2 ꭓ2=1 p=0 (p=0. CRD420234 (CRD4202348 (I ꭓ2= p= (p=0 CRD42023 (CRD420234 (p= CRD4202 (CRD42023 (p CRD420 (CRD4202 CRD42 (CRD420 CRD4 (CRD42 (CRD4 (CRD

SUMMARY OBJECTIVE: Coronary artery disease is the leading cause of death worldwide. Vascular endothelial growth factor is known to induce endothelial cell migration and proliferation, increase vascular permeability, and modulate thrombogenicity. The aim of this study is to investigate the relationship between the VEGF insertion/deletion (I/D) variant (rs35569394) and coronary artery disease susceptibility in the Turkish population. METHODS: A total of 206 subjects, including 106 coronary artery disease patients and 100 controls, were included in this study. The VEGF I/D variant was genotyped using the polymerase chain reaction method. RESULTS: The frequency of the I/I, I/D, and D/D genotypes was 35.84 versus 37%, 33.97 versus 36%, and 30.19 versus 27% in patients and the control group, respectively. VEGF I/D genotype and allele distribution were not statistically significant between coronary artery disease patients and controls (p>0.05). There was no significant difference between VEGF I/D genotype distribution and patient characteristics including age, gender, disease duration, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, history of hypertension, history of diabetes mellitus, and smoking (p>0.05). CONCLUSION: This study suggests that the VEGF I/D variant is not a predisposing factor to coronary artery disease disease in a Turkish sample. OBJECTIVE worldwide proliferation permeability thrombogenicity insertiondeletion insertion deletion ID I D (I/D rs35569394 rs (rs35569394 population METHODS 20 subjects 10 method RESULTS II I/I DD 3584 35 84 35.8 37 37% 3397 33 97 33.9 36 36% 3019 30 19 30.1 27 group respectively p>0.05. p005 p p>0.05 . 0 05 (p>0.05) age gender duration highdensity high density cholesterol lowdensity low triglyceride hypertension mellitus CONCLUSION sample rs3556939 (rs3556939 2 1 358 3 8 35. 339 9 33. 301 30. p00 p>0.0 (p>0.05 rs355693 (rs355693 p0 p>0. (p>0.0 rs35569 (rs35569 p>0 (p>0. rs3556 (rs3556 p> (p>0 rs355 (rs355 (p> rs35 (rs35 (p rs3 (rs3 (rs

SUMMARY OBJECTIVE: This randomized clinical trial study aims to investigate the effects of antioxidant food supplementation on the total antioxidant capacity of seminal plasma, sperm DNA fragmentation, sperm chromatin quality, and semen parameters. METHODS: In this study, a total of 48 subfertile men with moderate physical activity were included. Group 1 was recommended to use the antioxidant supplements, while antioxidant food supplements were not given to Group 2. Total antioxidant capacity, sperm DNA fragmentation, sperm chromatin structure, hormone levels, physical activities, and semen parameters were evaluated before and after treatment. Total antioxidant capacity, sperm DNA fragmentation, and sperm chromatin structure were assessed using ELISA, transferase dUTP nick end labeling, and aniline blue staining, respectively. RESULTS: Sperm DNA fragmentation (p=0.003) and histone/protamine ratio (p<0.001) were significantly decreased in the patients receiving antioxidant treatment. There was no statistical difference in the total antioxidant capacity values of the post-treatment groups. CONCLUSION: Antioxidant therapy seems to improve sperm DNA fragmentation and histone/protamine ratios in subfertile patients. Clinical Trial Registration Number: NCT06042738. OBJECTIVE plasma quality METHODS 4 included 2 levels activities treatment ELISA labeling staining respectively RESULTS p=0.003 p0003 p 0 003 (p=0.003 histoneprotamine histone protamine p<0.001 p0001 001 (p<0.001 posttreatment post groups CONCLUSION Number NCT06042738 NCT p=0.00 p000 00 (p=0.00 p<0.00 (p<0.00 NCT0604273 p=0.0 p00 (p=0.0 p<0.0 (p<0.0 NCT060427 p=0. p0 (p=0. p<0. (p<0. NCT06042 p=0 (p=0 p<0 (p<0 NCT0604 p= (p= p< (p< NCT060 (p NCT06 NCT0

SUMMARY OBJECTIVE: The aim of the study was to compare the postoperative effects of endotracheal tube cuff inflation with alkalized lidocaine in patients undergoing thyroidectomy surgery. METHODS: This is a randomized, double-blind clinical trial between August 2020 and August 2022 at the Hospital São Domingos, São Luís, Maranhão, Brazil. Patients over 18 years who underwent thyroidectomy of both sexes, American Society of Anesthesiologists (ASA) I or ASA II, were included. Patients with difficult orotracheal intubation, smoking, cuff rupture during orotracheal intubation, heart, lung, or neuropathies, previous surgery of the larynx or trachea, with risk of aspiration of gastric contents, or with the need to use a nasogastric tube were excluded. Patients were randomly selected and divided into the control group, whose cuff was filled with 0.9% saline solution, and the alkalinized lidocaine group, where the cuff was filled with 2% lidocaine and 8.4% sodium bicarbonate. RESULTS: The control group had higher systolic blood pressure [137 (94–183) mmHg] medians after extubation than the alkalinized lidocaine group [127 (82–189) mmHg] (p=0.03). The same was observed in heart rate values [control group: 86 (62–120); alkalinized lidocaine group: 80 (53–120)] (p=0.034). The alkalinized lidocaine group showed a significant increase in the ability to sustain phonation in the 24 h postoperatively, from 82.0 to 98.0% (p=0.031). CONCLUSION: There was no protective effect of the use of alkalinized lidocaine on the sensation of swallowing and complaints after thyroidectomy surgery. There was a significant improvement in hemodynamic response in the intervention group after extubation. OBJECTIVE METHODS randomized doubleblind double blind 202 Domingos Luís Maranhão Brazil 1 sexes (ASA II included intubation smoking lung neuropathies trachea contents excluded 09 0 9 0.9 solution 2 84 8 4 8.4 bicarbonate RESULTS 137 [13 94–183 94183 94 183 (94–183 mmHg 127 [12 82–189 82189 82 189 (82–189 p=0.03. p003 p p=0.03 . 03 (p=0.03) 62–120 62120 62 120 (62–120) 53–120 53120 53 (53–120) p=0.034. p0034 p=0.034 034 (p=0.034) postoperatively 820 82. 980 98 98.0 p=0.031. p0031 p=0.031 031 (p=0.031) CONCLUSION 20 0. 8. 13 [1 94–18 9418 (94–18 12 82–18 8218 (82–18 p00 p=0.0 (p=0.03 62–12 6212 6 (62–120 53–12 5312 5 (53–120 (p=0.034 98. (p=0.031 [ 94–1 941 (94–1 82–1 821 (82–1 p0 p=0. (p=0.0 62–1 621 (62–12 53–1 531 (53–12 94– (94– 82– (82– p=0 (p=0. 62– (62–1 53– (53–1 (94 (82 p= (p=0 (62– (53– (9 (8 (p= (62 (53 ( (p (6 (5

SUMMARY OBJECTIVE: Vascular endothelial growth factor is a signaling protein created by cells performing important bodily functions. Vascular endothelial growth factor is abundant in the lung, and plasma levels are elevated in patients with severe pulmonary arterial hypertension. An association between soluble urokinase plasminogen activator receptor, an inflammatory biomarker, and soluble urokinase plasminogen activator receptor levels and interstitial pulmonary and vascular involvement (e.g., development of pulmonary hypertension) has been shown in SSc patients. The tricuspid annular plane systolic excursion/systolic pulmonary artery pressure ratio, which has been recommended as a useful diagnostic tool in the last guideline, is one of the additional echocardiographic signs suggestive of pulmonary hypertension. We aimed to examine whether these biomarkers contribute to the diagnosis and management of pulmonary hypertension. METHODS: Patients with group E chronic obstructive lung disease were included in this prospective study. Demographic data, echocardiographic signs about the right ventricle (right atrium area, tricuspid annular plane systolic excursion/systolic pulmonary artery pressure, fractional area change, and right ventricular outflow tract), and peripheral blood analysis were examined and recorded. RESULTS: A total of 70 patients, 12 of whom were female, were analyzed in the study. The mean age was 66.6±8.7 years. The mean vascular endothelial growth factor-A and soluble urokinase plasminogen activator receptor were 91.05±70.7 and 955.8±571.1, and their Pearson correlation coefficients between vascular endothelial growth factor-A and tricuspid annular plane systolic excursion/systolic pulmonary artery pressure, and soluble urokinase plasminogen activator receptor and tricuspid annular plane systolic excursion/systolic pulmonary artery pressure ratio were 0.341 (p=0.004) and −0.045 (p=0.70), respectively. The linear regression model included four variables with significant correlation (vascular endothelial growth factor-A, right atrium area, fractional area change, and right ventricular outflow tract). Three steps were performed, and adjusted r2 was 0.22, 0.22, 0.20, and p<0.001 for each step. Vascular endothelial growth factor-A and right ventricular outflow tract remained in the last step. It was detected a standardized coefficient beta of 0.322 (p=0.004) and a 95%CI 0.000–0.001 for vascular endothelial growth factor-A. CONCLUSION: Vascular endothelial growth factor-A is correlated with the tricuspid annular plane systolic excursion/systolic pulmonary artery pressure ratio and not with soluble urokinase plasminogen activator receptor. OBJECTIVE functions hypertension biomarker e.g., eg e g (e.g. excursionsystolic excursion guideline METHODS study data change tract, , tract) recorded RESULTS 7 1 female 66687 66 6 8 66.6±8. years factorA 9105707 91 05 91.05±70. 95585711 955 571 955.8±571.1 0341 0 341 0.34 p=0.004 p0004 p 004 (p=0.004 0045 045 −0.04 p=0.70, p070 p=0.70 (p=0.70) respectively factorA, A, tract. . performed r 022 22 0.22 020 20 0.20 p0001 001 p<0.00 step 0322 322 0.32 95CI CI 95 00000001 000 0.000–0.00 factorA. A. CONCLUSION e.g. (e.g 6668 66.6±8 910570 9 91.05±70 9558571 57 955.8±571. 034 34 0.3 p=0.00 p000 00 (p=0.00 04 −0.0 p07 p=0.7 (p=0.70 02 2 0.2 p<0.0 032 32 0000000 0.000–0.0 e.g 666 66.6± 91057 91.05±7 955857 5 955.8±571 03 3 0. p=0.0 p00 (p=0.0 −0. p0 p=0. (p=0.7 p<0. 000000 0.000–0. 66.6 9105 91.05± 95585 955.8±57 (p=0. −0 p=0 p<0 00000 0.000–0 66. 910 91.05 9558 955.8±5 (p=0 − p= p< 0000 0.000– 91.0 955.8± (p= 0.000 91. 955.8 (p 0.00 955. 0.0