ABSTRACT BACKGROUND: Understanding social determinants is crucial for implementing preventive strategies, especially for low birth weight (LBW)—a public health issue that severely increases the risk of morbimortality in children. OBJECTIVE: This study aimed to identify the factors associated with LBW among newborns, assisted by the Brazilian Unified Health System. DESIGN AND SETTING: It analyzed data from newborns and their mothers. The sample was selected by convenience from users of the public health system in Francisco Beltrão (Paraná, Brazil). METHODS: Cases (n = 26) were babies weighing ≤ 2,500 g and controls (n = 52) > 2,500 g. All babies were assessed and paired by sex and date of birth in a 1:2 proportion. Statistical power was computed a posteriori, revealing a power of 87% (α = 0.05). RESULTS: Strong and significant differences were found in the bivariate analysis, in which the number of current smokers or those who quit during pregnancy was higher among mothers of babies with LBW. Moreover, the gestational weeks were lower among these cases. Logistic regression models indicated that the gestational week (odds ratio [OR] = 0.17, 95% confidence interval [CI]:0.05–0.54) and fathers’ educational level (high school or above; OR = 0.22, 95% CI:0.06–0.99) were related to lower chances of low birth weight. CONCLUSIONS: Our findings confirm previous investigations on LBW's multi-causality, showing that the gestational week could reduce up to 82% chances of a baby being born with ≤ 2,500 g. Its association with paternal education underlines the importance of comprehensive policies to protect newborns. BACKGROUND strategies LBWa children OBJECTIVE System SETTING Paraná, Paraná (Paraná Brazil. Brazil . Brazil) METHODS n 26 2500 2 500 2,50 52 12 1 1: proportion posteriori 87 α 0.05. 005 0.05 0 05 0.05) RESULTS analysis Moreover cases odds [OR 017 17 0.17 95 CI0.05–0.54 CI005054 CI 0.05–0.54 54 [CI]:0.05–0.54 fathers high above 022 22 0.22 CI0.06–0.99 CI006099 0.06–0.99 06 99 CI:0.06–0.99 CONCLUSIONS LBWs s multicausality, multicausality multi causality, causality multi-causality 82 250 50 2,5 5 8 00 0.0 01 0.1 9 CI0 CI0.05–0.5 CI00505 005054 0.05–0.5 [CI]:0.05–0.5 02 0.2 CI0.06–0.9 CI00609 006099 0.06–0.9 CI:0.06–0.9 25 2, 0. CI0.05–0. CI0050 00505 0.05–0. [CI]:0.05–0. CI0.06–0. CI0060 00609 0.06–0. CI:0.06–0. CI0.05–0 CI005 0050 0.05–0 [CI]:0.05–0 CI0.06–0 CI006 0060 0.06–0 CI:0.06–0 CI0.05– CI00 0.05– [CI]:0.05– CI0.06– 006 0.06– CI:0.06– CI0.05 [CI]:0.05 CI0.06 0.06 CI:0.06 CI0.0 [CI]:0.0 CI:0.0 CI0. [CI]:0. CI:0. [CI]:0 CI:0 [CI]: CI: [CI] [CI

ABSTRACT BACKGROUND: A bibliometric analysis covering only the production of original studies or considering world production until 2022 has yet to be conducted. The creation and advancement of vaccines have also influenced research priorities, demonstrating the need for a new approach to this subject. OBJECTIVES: To analyze worldwide scientific production related to coronavirus disease 2019 (COVID-19) and the aged and to describe what has already been produced. DESIGN AND SETTING: Bibliometric analysis with a quantitative approach. METHOD: The search terms “COVID-19,” “SARS-CoV-2,” “Aged,” and “Elderly” were used to retrieve articles from the Web of Science database. A total of 684 articles were included in the analysis. Data were imported into RStudio Desktop Software and linked to R Software. The Bibliometrix R package and VOSviewer software were used for analysis. RESULTS: Most articles were published in 2020. These were produced by 4,937 authors and published in 379 journals. The keyword most used by the authors was “COVID-19.” Publications from 77 countries were obtained. China had the highest article production ranking, and Spain collaborated the most. The articles addressed the implications of the pandemic on the aged, the relationship between vaccination in the aged, and the implications for the disease itself. CONCLUSION: Further research should be conducted, mainly concerning vaccines and vaccination of the aged, owing to the need for and importance of immunization in this risk group, including assessing the long-term effects of vaccines. BACKGROUND 202 conducted priorities subject OBJECTIVES 201 COVID19 COVID 19 (COVID-19 SETTING METHOD COVID19, 19, “COVID-19, SARSCoV2, SARSCoV2 SARSCoV SARS CoV 2, 2 “SARS-CoV-2, Aged, Aged “Aged, Elderly “Elderly database 68 RESULTS 2020 4937 4 937 4,93 37 journals COVID19. 19. “COVID-19. 7 obtained ranking itself CONCLUSION group longterm long term 20 COVID1 1 (COVID-1 “COVID-19 “SARS-CoV-2 “Aged 6 493 93 4,9 3 (COVID- “COVID-1 “SARS-CoV- 49 9 4, (COVID “COVID- “SARS-CoV “COVID

ABSTRACT BACKGROUND: Ankle taping (AT) is effective in preventing ankle sprain injuries in most common sports and is employed in rehabilitation and prevention sports. OBJECTIVE: This study aimed to investigate the effectiveness of AT to restricting excessive frontal plane ankle movements in semi-professional basketball players throughout the training session. DESIGN AND SETTING: A cross-sectional study was performed at the Universidad Europea de Madrid. METHODS: Forty male and female semi-professional basketball players were divided into two groups. The ankle dorsiflexion range of motion (ROM) and interlimb asymmetries in a weight-bearing lunge position were evaluated at four time points: 1) with no tape, 2) before practice, at 30 min of practice, and 3) immediately after practice. RESULTS: In male basketball players, no differences were observed in the right and left ankles between the baseline and 30 min and between baseline and 90 min of assessment. In female athletes, significant differences were reported between baseline and pre-training assessments for the right ankle and also significant differences between baseline and 90 min in both ankles. CONCLUSIONS: Ankle taping effectively decreased the ankle dorsiflexion ROM in male and female basketball players immediately after application. However, ROM restriction was very low after 30 and 90 min, as assessed in a single basketball practice. Therefore, the classic taping method should be revised to develop new prophylactic approaches, such as the implementation of semi-rigid bracing techniques or the addition of active stripes during training or game pauses. BACKGROUND (AT OBJECTIVE semiprofessional semi professional session SETTING crosssectional cross sectional Madrid METHODS groups (ROM weightbearing weight bearing points 1 tape 2 practice 3 RESULTS 9 assessment athletes pretraining pre CONCLUSIONS application However Therefore approaches semirigid rigid pauses

ABSTRACT BACKGROUND: Current research supports the fact that prophylactic ankle taping (AT) is effective in preventing ankle injuries in amateur and elite sports athletes. OBJECTIVE: This study aimed to investigate the effect of AT on balance, knee valgus during drop jump and single-leg countermovement jump (SL-CMJ) landings, and ankle range of motion (ROM) restriction in healthy participants. DESIGN AND SETTING: A cross-sectional observational study was conducted at the Universidad Europea de Madrid, Madrid, Spain. METHODS: Participants: Thirty-nine healthy individuals participated in this study and performed the movements under two conditions (with and without tape). Outcome measurements: ankle ROM, balance, SL-CMJ height, flight time, ground time, and knee valgus. Before any intervention, a random process was developed with a 1:1 allocation ratio, and the participants were assigned to groups A (tape-no tape) and B (no tape-tape). RESULTS: Significant differences between tape and no-tape moments were observed for drop jump knee valgus flexion (P = 0.007), with an increase in knee valgus in participants with ankle taping. Similarly, the Y-balance testshowed a significant decrease in all variables (P = 0.001 and), ankle dorsiflexion (P = 0.001) in participants with ankle taping. CONCLUSIONS: AT is effective for immediate ankle ROM restriction. However, an increase in knee valgus during drop jump task and a decrease in lower limb balance were observed during drop jump task. Based on these results, it can be concluded that AT application in healthy individuals should not be recommended as it results in increase in injury risk factors. BACKGROUND (AT athletes OBJECTIVE singleleg single leg SLCMJ SL CMJ (SL-CMJ landings (ROM SETTING crosssectional cross sectional Madrid Spain METHODS Participants Thirtynine Thirty nine tape. . measurements height time intervention 11 1 1: ratio tapeno no tapetape. tapetape tape-tape) RESULTS notape P 0.007, 0007 0.007 , 0 007 0.007) Similarly Ybalance Y 0001 001 0.00 and, and) CONCLUSIONS However factors tape-tape 000 00 0.0 0.

ABSTRACT BACKGROUND: Nutritional status and growth curves can affect cognitive development, increase the risk of infection, and contribute to the development of chronic diseases. Its etiology is related to food, socioeconomic, and maternal conditions. However, to date, no data on these parameters exist in the state of Goiás, Brazil. OBJECTIVE: To compare the nutritional status and growth curves of children and adolescents in the city of Goiânia, Goiás, Brazil. DESIGN AND SETTING: This was a cross-sectional study. A total of 529 individuals were recruited from a primary health center in the municipality. METHODS: To assess nutritional status, the sample was divided into three categories: 3–4, 5–10, and 11–19 years, with z-score classification considering body mass index for age. The classification of growth curves was performed considering the median height values for age, assuming two references: (a) young Brazilian population and (b) one recommended for international use. The independent sample T-test was used to compare anthropometric variables. RESULTS: The results showed that the classification of eutrophics represents a predominant percentage between both sexes (men: 03–04 = 55.4%; 05–10 = 57.6%; 11–19 = 53.5 % and women: 03–04 = 53.5%; 05–10 = 63.9%; 11–19 = 56.9%), and growth curves showed differences in specific periods in both sexes. CONCLUSIONS: It can be concluded that children and adolescents from the city of Goiânia present as predominance the eutrophic nutritional status, followed by the risk of overweight, underweight, obesity, and malnutrition of both sexes. BACKGROUND infection diseases food socioeconomic conditions However date Goiás Brazil OBJECTIVE SETTING crosssectional cross sectional study 52 municipality METHODS categories 34 3 4 3–4 510 5 10 5–10 1119 11 19 11–1 years zscore z score age references (a b (b use Ttest T test variables RESULTS men (men 0304 03 04 03–0 55.4% 554 55 0510 05 05–1 57.6% 576 57 6 535 53 53. women 53.5% 63.9% 639 63 9 56.9%, 569 56.9% , 56 56.9%) CONCLUSIONS overweight underweight obesity 3– 51 1 5–1 111 11– 030 0 03– 55.4 051 05– 57.6 63.9 56.9 5– 55. 57. 63. 56.

ABSTRACT BACKGROUND: Precisely determining the aspects related to an instrument's validity and reliability measures allows for greater assurance of the quality of the results. OBJECTIVES: To analyze the psychometric properties of The Providers Survey in the Brazilian context of mental health services. DESIGN AND SETTING: The instrument validation study was conducted in Montes Claros, Minas Gerais, Brazil. METHODS: The validation study was conducted using the Consensus-based Standards for the Selection of Health Measurement Instruments checklist to analyze its validity and reliability. RESULTS: A committee of expert judges performed content validation after which the Content Validity Index was calculated. Construct validation took place through Exploratory Factor Analysis using the Kaiser-Meyer-Olkin Test criterion and Bartlett's Sphericity Test. Reliability was verified using test-retest reliability. The significance level adopted for the statistical tests was 5% (P < 0.05). The final instrument comprised 54 questions. The Content Validity Index was 97%. Exploratory Factor Analysis identified a Kaiser-Meyer-Olkin index of 0.901 and Bartlett's Sphericity Test with P < 0.001. We obtained a Cronbach's alpha coefficient of 0.95 and an intraclass correlation coefficient of 0.849. CONCLUSIONS: The Providers Survey, translated and adapted into Portuguese, was named the Work Assessment Instrument for the Recovery of Mental Health. It presented adequate psychometric properties for evaluating work-related practices for the recovery of psychosocial care network users. BACKGROUND instruments s results OBJECTIVES services SETTING Claros Gerais Brazil METHODS Consensusbased Consensus based RESULTS calculated KaiserMeyerOlkin Kaiser Meyer Olkin Bartletts Bartlett testretest test retest 5 0.05. 005 0.05 . 0 05 0.05) questions 97 97% 0901 901 0.90 0001 001 0.001 Cronbachs Cronbach 095 95 0.9 0849 849 0.849 CONCLUSIONS Portuguese workrelated work users 00 0.0 9 090 90 000 0.00 09 0. 084 84 0.84 08 8 0.8

ABSTRACT BACKGROUND: Given the characteristics of military missions, intense interpersonal contact, and wide variation in casual relationships, the military has long been recognized as a high-risk population for sexually transmitted infections (STIs). OBJECTIVE: To assess the prevalence of STIs and socioepidemiological profile of women in the military garrison of Campinas. DESIGN AND SETTING: This prospective, cross-sectional epidemiological study, assisted by the Health Fund in the military garrison of Campinas, assessed the prevalence of human immunodeficiency virus (HIV), hepatitis B and C, syphilis, human papillomavirus (HPV), chlamydia, and gonococcus in military women or companions of soldiers with active or previously active sexual life. METHODS: This study included 647 women based on the non-inclusion criteria. They underwent clinical and laboratory tests for diagnosis of STIs. For statistical analysis, patients were divided into groups according to the presence or absence of STIs and into age groups. RESULTS: Most women were military dependents, and the majority were asymptomatic. The prevalence of STIs, in ascending order, was 0.3% for hepatitis B and C, 0.62% for syphilis, 0.62% for gonorrhea, 1.08% for chlamydia, and 2.63% for HPV. There were no cases of HIV infection. CONCLUSIONS: The Brazilian Army has the most women-like dependents in the military, belonging to the hierarchical circle of the squares. Early onset of sexual activity favored STIs approximately twice, and younger women had approximately seven times more chlamydia infections. In the general population studied, the prevalence of STIs was lower than expected than in the armed forces of other nations. BACKGROUND missions contact relationships highrisk high risk . (STIs) OBJECTIVE Campinas SETTING prospective crosssectional cross sectional HIV, , (HIV) C syphilis HPV, HPV (HPV) life METHODS 64 noninclusion non inclusion criteria analysis RESULTS asymptomatic order 03 0 3 0.3 062 62 0.62 gonorrhea 108 1 08 1.08 263 2 63 2.63 infection CONCLUSIONS womenlike like squares twice studied nations (STIs (HIV (HPV 6 0. 06 0.6 10 1.0 26 2.6 1. 2.

ABSTRACT BACKGROUND: We aimed to develop and validate a practical instrument to assess older adults’ satisfaction with their social participation (SP). DESIGN AND SETTING: This methodological validation study was conducted at a public higher education institution. METHODS: A two-phase study was designed, developed, and validated to assess older adults’ satisfaction with their SP. In the first phase, we conceptualized SP and developed an “instrument to assess older adults’ satisfaction with their SP (IAPSI),” as approved by a committee of specialists, pre-tested, and partially validated. Second, we determined the IAPSI’s reproducibility using Cronbach’s alpha to measure internal consistency, Pearson’s and Spearman’s coefficients to measure correlations, the Bland-Altman plot and intraclass correlation coefficient (ICC) to measure reproducibility. We also generated a receiver operating characteristic (ROC) curve. RESULTS: 102 older adults (mean age, 87.29) participated in the first phase. Moderate internal consistency (Cronbach’s alpha 0.7) and significant moderate correlations with quality of life by World Health Organization Quality of Life (WHOQOL)-bref and by WHOQOL-old social domains (Pearson’s coefficients 0.54 and 0.64, respectively; P < 0.001) were found. The ROC curve indicated an IAPSI score of 17 as the threshold for the impact of pain on satisfaction with SP (83.3% sensitivity and 88.9% specificity, P < 0.001). In the second phase, 56 older adults (between 81 and 90 years old) participated. We found adequate intra- and inter-observer reproducibility for the IAPSI (ICC 0.96 and 0.78, respectively). CONCLUSION: We have developed a practical instrument with appropriate psychometric properties to assess older adults’ satisfaction with their SP. BACKGROUND . (SP) SETTING institution METHODS twophase two phase designed IAPSI, , (IAPSI), specialists pretested, pretested pre tested, tested pre-tested Second IAPSIs s Cronbachs Cronbach Pearsons Pearson Spearmans Spearman BlandAltman Bland Altman ICC (ROC RESULTS 10 mean age 87.29 8729 87 29 0.7 07 0 7 WHOQOLbref WHOQOL bref WHOQOLold old 054 54 0.5 064 64 0.64 respectively 0.001 0001 001 1 83.3% 833 83 3 (83.3 889 88 9 88.9 specificity 0.001. 5 between 8 intra interobserver inter observer 096 96 0.9 078 78 0.78 respectively. respectively) CONCLUSION (SP (IAPSI) 87.2 872 2 0. 05 06 6 0.6 0.00 000 00 83.3 (83. 88. 09 (IAPSI 87. 0.0 83. (83 (8 (

ABSTRACT BACKGROUND: The epidemiology of potentially inappropriate medications (PIMs) in critical care units remains limited, especially in terms of the factors associated with their use. OBJECTIVE: To estimate the incidence and factors associated with PIMs use in intensive care units. DESIGN AND SETTING: Historical cohort study was conducted in a high-complexity hospital in Brazil. METHODS: A retrospective chart review was conducted on 314 patients aged ≥ 60 years who were admitted to intensive care units (ICUs) at a high-complexity hospital in Brazil. The dates were extracted from a “Patient Safety Project” database. A Chi-square test, Student’s t-test, and multivariable logistic regression analyses were performed to assess which factors were associated with PIMs. The statistical significance was set at 5%. RESULTS: According to Beers’ criteria, 12.8% of the identified drugs were considered inappropriate for the elderly population. The incidence rate of PIMs use was 45.8%. The most frequently used PIMs were metoclopramide, insulin, antipsychotics, non-steroidal anti-inflammatory drugs, and benzodiazepines. Factors associated with PIMs use were the number of medications (odds ratio [OR] = 1.17), length of hospital stay (OR = 1.07), and excessive potential drug interactions (OR = 2.43). CONCLUSIONS: Approximately half of the older adults in ICUs received PIM. Patients taking PIMs had a longer length of stay in the ICU, higher numbers of medications, and higher numbers of potential drug interactions. In ICUs, the use of explicit methods combined with clinical judgment can contribute to the safety and quality of medication prescriptions. BACKGROUND (PIMs limited OBJECTIVE SETTING highcomplexity high complexity Brazil METHODS 31 6 (ICUs Patient Project database Chisquare Chi square test Students Student s ttest, ttest t t-test 5 5% RESULTS Beers criteria 128 12 8 12.8 population 458 45 45.8% metoclopramide insulin antipsychotics nonsteroidal non steroidal antiinflammatory anti inflammatory benzodiazepines odds OR [OR 1.17, 117 1.17 , 1 17 1.17) 1.07, 107 1.07 07 1.07) 2.43. 243 2.43 . 2 43 2.43) CONCLUSIONS PIM ICU prescriptions 3 12. 4 45.8 11 1.1 10 1.0 0 24 2.4 45. 1. 2.

ABSTRACT BACKGROUND: Stroke is a major cause of mortality worldwide. Renal dysfunction is an important risk factor for stroke. Brazilian studies on stroke knowledge are generally population based. Studies stratifying stroke knowledge according to comorbidities are rare. Scientific data are essential to guide the awareness of stroke. OBJECTIVE: To assess stroke knowledge in patients with chronic kidney disease (CKD) on hemodialysis. DESIGN AND SETTING: Cross-sectional analytical study of patients with CKD on hemodialysis in north-eastern Brazil. METHODS: A self-administered questionnaire survey on stroke awareness was administered to patients with CKD on hemodialysis between April and November 2022. The chi-square test and other descriptive statistics were used. Univariate and multivariate analyses were performed using logistic regression. RESULTS: A total of 197 patients were included in the analysis. The Brazilian acronym for stroke was used by 53.5% of the participants. Less than 10.0% of the sample showed optimal decision-making ability regarding stroke. Of the participants, 29.9% knew at least one risk factor and one symptom; however, this was considered as having below the minimum capacity because they did not know the emergency service call number. In the analysis adjusted for income and education, females (odds ratio [OR], 0.40%; 95% confidence interval [CI], 0.20-0.82), older patients (OR, 0.24%; 95% CI, 0.09-0.63) and having at most one comorbidity (OR, 0.48%; 95% CI, 0.23-0.98) were factors for lower levels of knowledge or ideal decision-making capacity against stroke. CONCLUSIONS: Patients on hemodialysis, especially women and older people, have little knowledge about stroke. BACKGROUND worldwide based rare OBJECTIVE (CKD SETTING Crosssectional Cross sectional northeastern north eastern Brazil METHODS selfadministered self 2022 chisquare chi square regression RESULTS 19 535 53 5 53.5 participants 100 10 0 10.0 decisionmaking decision making 299 29 9 29.9 symptom however number education odds OR, OR , [OR] 0.40% 040 40 95 CI [CI] 0.200.82, 020082 0.20 0.82 20 82 0.20-0.82) (OR 0.24% 024 24 0.090.63 009063 0.09 0.63 09 63 0.09-0.63 0.48% 048 48 0.230.98 023098 0.23 0.98 23 98 0.23-0.98 CONCLUSIONS people 202 1 53. 10. 2 29. [OR 0.40 04 4 [CI 200 0.200.82 02008 020 0.2 082 0.8 8 0.20-0.82 0.24 02 090 0.090.6 00906 009 0.0 063 0.6 6 0.09-0.6 0.48 230 0.230.9 02309 023 098 0.9 0.23-0.9 0.4 0.200.8 0200 0. 08 0.20-0.8 0.090. 0090 00 06 0.09-0. 0.230. 0230 0.23-0. 0.200. 0.20-0. 0.090 0.09-0 0.230 0.23-0 0.200 0.20-0 0.09- 0.23- 0.20-

ABSTRACT BACKGROUND: There is a lack of studies evaluating the oral health of traditional indigenous communities in Brazil. OBJECTIVES: Thus, the objective of this study was to describe the oral health characteristics of the indigenous Fulni-ô ethnic group in Northeast Brazil. DESIGN AND SETTING: A cross-sectional observational investigation was conducted within the Project on Atherosclerosis among Indigenous Populations. METHODS: This study included participants of both sexes from the Fulni-ô ethnic group. The participants included in this investigation underwent a comprehensive oral health evaluation by a registered and experienced dentist to assess oral health and identify potentially malignant oral lesions. Participants with suspicious lesions were referred for biopsy. Shapiro-Wilk, Mann-Whitney, and Student’s t-tests were used, and measures of central tendency and dispersion were described. Statistical significance was 5%. RESULTS: A total of 104 individuals were included in this study. The prevalence of the use of tobacco derivatives was 94.0%, with similarities between sexes. The prevalence of oral changes in this study population was 84.4%. Fifty-one individuals who underwent oral reassessment were referred for oral lesion biopsy. CONCLUSIONS: This study demonstrated a high prevalence of oral alterations in the Fulni-ô population. Histopathological analyses indicated the presence of mild oral epithelial dysplasia in five cases. BACKGROUND Brazil OBJECTIVES Thus Fulniô Fulni ô SETTING crosssectional cross sectional Populations METHODS biopsy ShapiroWilk, ShapiroWilk Shapiro Wilk, Wilk Shapiro-Wilk MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney Students Student s ttests t tests used described 5 5% RESULTS 10 940 94 0 94.0% 844 84 4 84.4% Fiftyone Fifty one CONCLUSIONS cases 1 9 94.0 8 84.4 94. 84.

ABSTRACT BACKGROUND: Down syndrome (DS) is a non-rare genetic condition that affects approximately 1 in every 800 live births worldwide. Further, it is associated with comorbidities, anatomical alterations of the respiratory tract, and immunological dysfunctions that make individuals more susceptible to respiratory infections. OBJECTIVE: To systematize the current scientific knowledge about the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among individuals with DS. DESIGN AND SETTING: This integrative review was conducted at the Universidade Federal de São Carlos, São Paulo, Brazil. METHODS: This review was conducted in the following databases: the Virtual Health Library (Biblioteca Virtual em Saúde, BVS), PubMed, and Web of Science, using MeSH descriptors. The search included English or Portuguese studies published between January 1, 2020, and October 14, 2022. RESULTS: A total of 55 articles from 24 countries were selected, comprising 21 case-control or cohort studies, 23 case reports or series, and 11 narrative reviews or opinion studies. The articles were grouped into five categories: previous comorbidities, coronavirus disease 2019 (COVID-19) clinical features and evolution, cytokine storm and interleukins, living in institutions as a risk factor, and behavioral actions as a protective factor against SARS-CoV-2 infection. CONCLUSION: Individuals with DS are more susceptible to COVID-19 infection due to variables such as previous comorbidities, immunological factors, and their habitable environments. These aspects confer a higher risk of infection and an unfavorable clinical course. The precise pathways involved in the pathophysiology of COVID-19 in individuals with DS are not clear, thus requiring further studies. SYSTEMATIC REVIEW REGISTRATION: The Open Science Framework registered the research protocol (https://osf.io/jyb97/). BACKGROUND (DS nonrare non rare 80 worldwide Further comorbidities tract infections OBJECTIVE SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 SETTING Carlos Paulo Brazil METHODS databases Biblioteca Saúde BVS, BVS , BVS) PubMed descriptors 2020 14 2022 RESULTS 5 selected casecontrol control series categories 201 COVID19 COVID 19 (COVID-19 evolution interleukins SARS-CoV- CONCLUSION COVID-1 factors environments course clear REGISTRATION https//osf.io/jyb97/. httpsosfiojyb97 httpsosfiojyb https //osf.io/jyb97/ . osf io jyb97 jyb (https://osf.io/jyb97/) 8 (SARS-CoV- 202 20 COVID1 (COVID-1 SARS-CoV COVID- https//osf.io/jyb97/ httpsosfiojyb9 osfiojyb97 osfiojyb //osf.io/jyb97 jyb9 (https://osf.io/jyb97/ (SARS-CoV (COVID- https//osf.io/jyb97 osfiojyb9 //osf.io/jyb9 (https://osf.io/jyb97 (COVID https//osf.io/jyb9 //osf.io/jyb (https://osf.io/jyb9 https//osf.io/jyb (https://osf.io/jyb

ABSTRACT BACKGROUND: Abnormal uterine bleeding (AUB) is a common condition, and the Menstrual Bleeding Questionnaire (MBQ) is used for its assessment. OBJECTIVES: To translate, assess the cut-off point for diagnosis, and explore psychometric properties of the MBQ for use in Brazilian Portuguese. DESIGN AND SETTING: Prospective cohort study including 200 women (100 with and 100 without AUB) at a tertiary referral center. METHODS: MBQ translation involved a pilot-testing phase, instrument adjustment, data collection, and back-translation. Cut-off point was obtained using receiver operating curve analysis. Menstrual patterns, impact on quality of life due to AUB, internal consistency, test-retest, responsiveness, and discriminant validity were assessed. For construct validity, the Pictorial Blood Assessment Chart (PBAC) and World Health Organization Quality of Life – abbreviated version (WHOQOL-BREF) were applied. RESULTS: Women with AUB were older, had higher body mass indices, and had a worse quality of life during menstruation. Regarding the MBQ's psychometric variables, Cronbach's alpha coefficient was > 0.70 in all analyses, high intraclass correlation coefficient was found in both groups; no ceiling and floor effects were observed, and construct validity was demonstrated (correlation between MBQ score, PBAC score, and clinical menstrual cycle data). No difference between MBQ and PBAC scores were perceived after the test-retest. Significant differences were found between MBQ and PBAC scores before and after treatment. An MBQ score ≥ 24 was associated with a high probability of AUB; accuracy of 98%. CONCLUSION: The MBQ is a reliable questionnaire for Brazilian women. The cut-off ≥ 24 shows high accuracy to discriminate AUB. BACKGROUND (AUB condition (MBQ assessment OBJECTIVES translate cutoff cut off diagnosis Portuguese SETTING 20 (10 10 center METHODS pilottesting pilot testing phase adjustment collection backtranslation. backtranslation back translation. back-translation Cutoff Cut analysis patterns consistency testretest, testretest test retest, retest test-retest responsiveness assessed (PBAC WHOQOLBREF WHOQOL BREF (WHOQOL-BREF applied RESULTS older indices menstruation MBQs s variables Cronbachs Cronbach 070 0 70 0.7 analyses groups observed data. . data) testretest. retest. treatment 2 98 98% CONCLUSION (1 1 07 7 0. 9 (

ABSTRACT BACKGROUND: The identification and understanding of dietary factors and other characteristics that influence gestational weight gain can contribute to the formulation of strategies to promote healthy eating habits before and during pregnancy. OBJECTIVE: To investigate the association between dietary patterns, sociodemographic and obstetric characteristics, and health-related behaviors in pregnant women. DESIGN AND SETTING: A cross-sectional study was conducted on women undergoing prenatal care in the Unified Health System of Colombo, Paraná, Brazil, from February 2018 to September 2019. METHOD: A weekly food frequency questionnaire was administered, and dietary patterns were identified through factor analysis. Median regression models were constructed to identify the associations between dietary pattern scores and variables. RESULTS: Complete data were obtained from 495 pregnant women. Three dietary patterns were identified: 1) “healthy,” with higher factor loadings for the weekly consumption of raw vegetables, cooked vegetables, and fresh fruits; 2) “Western,” including soft drinks or artificial juice, candies, milk, and dairy products, and processed cold meat; and 3) “traditional,” beans and meat. Pregnant women aged 30 years or older (coefficient [Coef.] 0.86, 95% confidence interval [CI] 0.38–1.33) with moderate/intense physical activity (Coef. 0.32, 95% CI 0.02–0.62) had higher adherence to the “healthy” pattern. Adolescents and smokers adhered more to the “traditional” pattern (Coef. 0.17, 95% CI 0.01–0.33). CONCLUSION: Age, smoking status, and physical activity were associated with dietary patterns in pregnant women. BACKGROUND pregnancy OBJECTIVE healthrelated health related SETTING crosssectional cross sectional Colombo Paraná Brazil 201 2019 METHOD administered analysis variables RESULTS 49 1 healthy, “healthy, vegetables fruits 2 Western, Western “Western, juice candies milk products meat 3 traditional, traditional “traditional, coefficient Coef. Coef [Coef. 086 0 86 0.86 95 [CI 0.38–1.33 038133 38 33 moderateintense moderate intense (Coef 032 32 0.32 0.02–0.62 002062 02 62 “healthy “traditional 017 17 0.17 0.01–0.33. 001033 0.01–0.33 . 01 0.01–0.33) CONCLUSION Age status 20 4 “Western [Coef 08 8 0.8 9 0.38–1.3 03813 03 0.3 0.02–0.6 00206 6 0.1 00103 0.01–0.3 0. 0.38–1. 0381 0.02–0. 0020 0010 0.01–0. 0.38–1 038 0.02–0 002 001 0.01–0 0.38– 0.02– 00 0.01– 0.38 0.02 0.01 0.0

ABSTRACT BACKGROUND: Managing cervical intraepithelial neoplasia grade 2 (CIN2) is challenging, considering the CIN2 regression rate, perinatal risks associated with excisional procedures, and insufficient well-established risk factors to predict progression. OBJECTIVES: To determine the ability of p16INK4a and Ki-67 staining in biopsies diagnosed with CIN2 to identify patients with higher-grade lesions (CIN3 or carcinoma). DESIGN AND SETTING: Cross-sectional study conducted at a referral center for treating uterine cervical lesions. METHODS: In 79 women, we analyzed the correlation of p16INK4a and Ki-67 expression in CIN2 biopsies with the presence of a higher-grade lesions, as determined via histopathology in surgical specimens from treated women or via two colposcopies and two cytological tests during follow-up for untreated women with at least a 6-month interval. The expression of these two biomarkers was verified by at least two independent pathologists and quantified using digital algorithms. RESULTS: Thirteen (16.8%) women with CIN2 biopsy exhibited higher-grade lesions on the surgical excision specimen or during follow-up. p16INK4a expression positively and negatively predicted the presence of higher-grade lesions in 17.19% and 86.67% patients, respectively. Ki-67 expression positively and negatively predicted the presence of higher-grade lesions in 40% and 88.24% patients, respectively. CONCLUSIONS: Negative p16INK4a and Ki67 immunohistochemical staining can assure absence of a higher-grade lesion in more than 85% of patients with CIN2 biopsies and can be used to prevent overtreatment of these patients. Positive IHC staining for p16INK4a and Ki-67 did not predict CIN3 in patients with CIN2 biopsies. BACKGROUND CIN (CIN2 challenging rate procedures wellestablished well established progression OBJECTIVES pINKa p INK Ki 67 Ki-6 highergrade higher (CIN carcinoma. carcinoma . carcinoma) SETTING Crosssectional Cross sectional METHODS 7 followup follow up 6month month 6 interval algorithms RESULTS 16.8% 168 16 8 (16.8% followup. up. 1719 17 19 17.19 8667 86 86.67 respectively 40 8824 88 24 88.24 CONCLUSIONS Ki6 85 Ki- 16.8 1 (16.8 171 17.1 866 86.6 4 882 88.2 16. (16. 17. 86. 88. (16 (1 (