Abstract Introduction Postoperative sore throat (POST) is a fairly common side effect of general anesthesia. The K-Y jelly is a well-known lubricant used in many medical procedures. Objective In this randomized study, we evaluated the use of throat packs soaked with K-Y jelly for POST outcomes in patients submitted to nasal surgery. Methods The present double-blinded, randomized, controlled study included 140 ASA I–II patients undergoing nasal surgery under general anesthesia. Patients received either or K-Y jelly or water-soaked X-ray detectable throat packs fully inserted into the mouth to occlude the oropharynx. Results Comparison between the studied groups regarding the severity of POST assessed by visual analog scale revealed significantly lower POST levels in the K-Y jelly group on recovery from anesthesia, and at 2, 4, and 6 hours postoperatively. Conclusions The use of K-Y jelly-soaked throat packs was associated with less severe POST after nasal surgery. (POST anesthesia KY K Y wellknown well known procedures doubleblinded, doubleblinded double blinded, blinded double-blinded 14 III I II watersoaked water Xray X ray oropharynx 2 4 postoperatively jellysoaked 1

Abstract Introduction Despite the high level of patient satisfaction with functional endoscopic sinus surgery (FESS) and the clinical improvement, polyp recurrence is observed in 23% to 87% of patients and requires reoperation. Objective To assess the prognostic value of polypoid changes of the middle turbinate (PCMT) in relapse of paranasal sinus polyps in patients with chronic rhinosinusitis with nasal polyp (CRSwNP) after FESS and the effect of partial middle turbinectomy (PMT) on the outcome of surgery. Methods We conducted a prospective clinical study on 60 patients with CRSwNP with and without PCMT. The patients were allocated into three groups: group I included twenty patients without PCMT; group II, twenty patients with PCMT; and group III included twenty patients with PCMT submitted to PMT. The patients were evaluated endoscopically according to the Lund-Kennedy endoscopic scoring system, radiologically according to the Lund-Mackay scoring system, and symptomatically through the 22-item Sinonasal Outcome Test (SNOT-22). Results The total postoperative Lund-Kennedy score differed significantly among the 3 groups (p < 0.001), with a group II presenting a significantly higher total score compared to groups I and III. The Preoperative SNOT-22 score differed significantly among the three groups (p = 0.013), with group II presenting a significantly higher score compared to group I. There was a significant association involving the 3 groups and relapse at 12 months (p = 0.029); relapse was higher in group II (50.0%) than in groups I (20%) and III (15.0%). Conclusion There was a significant association between PCMT and the relapse of nasal polyps. Also, nasal polyposis recurred at a lower rate in the group submitted to middle turbinate resection compared to the group in whom it was preserved. (FESS improvement 23 87 reoperation (PCMT (CRSwNP PMT (PMT 6 LundKennedy Lund Kennedy system LundMackay Mackay 22item item 22 SNOT22. SNOT22 SNOT . (SNOT-22) p 0.001, 0001 0.001 , 0 001 0.001) SNOT-2 0.013, 0013 0.013 013 0.013) 1 0.029 0029 029 0.029) 50.0% 500 50 (50.0% 20% 20 (20% 15.0%. 150 15.0% 15 (15.0%) Also preserved 2 8 SNOT2 (SNOT-22 000 0.00 00 SNOT- 0.01 01 0.02 002 02 50.0 5 (50.0 (20 15.0 (15.0% (SNOT-2 0.0 50. (50. (2 15. (15.0 (SNOT- 0. (50 ( (15. (SNOT (5 (15 (1

Abstract Introduction Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has cast a gloom spell on healthcare worldwide, infecting millions of people. Objective The aim of the present study is to determine the prevalence and review the contributing comorbidities and the precipitating factors leading to the emergence of the fungal infections in COVID-19-affected patients. To assess the utility of different laboratory techniques for confirmation of fungal infections. To assess the strengths and limitations of the diagnostic methods. Methods We have studied 252 clinical samples obtained from 121 COVID-positive patients. Results Among the 121 patients clinically diagnosed with fungal infections, 88 had diabetes and were given steroids for treatment (p-value = 0.001). Ninety-five patients (78.5%) had a positive laboratory diagnosis (either culture positive, potassium hydroxide [KOH]-positive or positive histopathology report). Fungal culture was positive in 75 (61.9%) patients and histopathology report was positive in 62 (51.2%). Histopathology was positive in 7 (5.8%) patients in whom culture and KOH were negative. Conclusion Aggressive treatment methods, administration of immune suppressants, and antibiotics, with an intention to salvage, have made patients susceptible to the benign fungus, causing it to evade the host immunity, thus leading to invasive infections. Applying different laboratory modalities would not only aid in providing fast and valuable information but also help in understanding the pathology which would assist the clinician in selecting the correct treatment for the patient. 201 COVID19 COVID 19 (COVID-19 SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 worldwide people COVID19affected COVIDaffected affected methods 25 12 COVIDpositive 8 pvalue p value 0.001. 0001 0.001 . 0 001 0.001) Ninetyfive Ninety five 78.5% 785 78 5 (78.5% either KOHpositive report. report) 61.9% 619 61 9 (61.9% 6 51.2%. 512 51.2% 51 (51.2%) 5.8% 58 (5.8% negative suppressants antibiotics salvage fungus immunity patient 20 COVID1 1 (COVID-1 (SARS-CoV- 000 0.00 00 78.5 (78.5 61.9 (61.9 51.2 (51.2% 5.8 (5.8 (COVID- (SARS-CoV 0.0 78. (78. 61. (61. 51. (51.2 5. (5. (COVID 0. (78 (61 (51. (5 (7 (6 (51 (

Abstract Introduction Primary care physicians are essential first points of contact for patients with hearing loss. Thus, knowledge of hearing loss and related aspects is essential to ensure the optimal management of individuals with suspected hearing loss. Objective This study aimed to determine the knowledge of and attitudes toward hearing loss among primary care physicians in the public health sector in Mauritius. Methods In this cross-sectional descriptive cohort study, 320 primary care physicians completed an online questionnaire adapted from previous questionnaires on knowledge of and attitudes toward hearing loss. Responses were analyzed using descriptive statistics and cross-sectional analyses. Results Primary care physicians showed limited knowledge of hearing loss in areas such as early identification and intervention, professionals responsible for hearing assessments, and hearing tests used for assessing hearing sensitivity. However, the responses also showed positive attitudes toward hearing loss. Significant associations between knowledge of and attitudes toward hearing loss were obtained regarding the type of physician, length of practice, and department posted in. Ear, nose, and throat specialists, as well as pediatricians, demonstrated significantly higher scores for both knowledge of and positive attitudes toward hearing loss. Conclusions The findings highlight a strong need for ongoing medical education to spread awareness about hearing loss among primary care physicians in the public health sector of Mauritius. Thus Mauritius crosssectional cross sectional 32 analyses intervention assessments sensitivity However physician practice Ear nose specialists pediatricians 3

Abstract Introduction Facial nerve stimulation (FNS) is a complication in cochlear implant (CI) when the electrical current escapes from the cochlea to the nearby facial nerve. Different management to reduce its effects are available, although changes might result in a less-than-ideal fitting for the CI user, eventually reducing speech perception. Objective To verify the etiologies that cause FNS, to identify strategies in managing FNS, and to evaluate speech recognition in patients who present FNS. Methods Retrospective study approved by the Ethical Board of the Institution. From the files of a CI group, patients who were identified with FNS either during surgery or at any time postoperatively were selected. Data collection included: CI manufacturer, electrode array type, age at implantation, etiology of hearing loss, FNS identification date, number of electrodes that generated FNS, FNS management actions, and speech recognition in quiet and in noise. Results Data were collected from 7 children and 25 adults. Etiologies that cause FNS were cochlear malformation, head trauma, meningitis, and otosclerosis; the main actions included decrease in the stimulation levels followed by the deactivation of electrodes. Average speech recognition in quiet before FNS was 86% and 80% after in patients who were able to accomplish the test. However, there was great variability, ranging from 0% in quiet to 90% of speech recognition in noise. Conclusion Etiologies that cause FNS are related to cochlear morphology alterations. Facial nerve stimulation can be solved using speech processor programming parameters; however, it is not possible to predict outcomes, since results depend on other variables. (FNS (CI available lessthanideal less than ideal user perception Institution group selected manufacturer type implantation loss date noise 2 adults malformation trauma meningitis otosclerosis 86 80 test However variability 0 90 alterations parameters however outcomes variables 8 9

Abstract Introduction Obstructive sleep apnea (OSA) is a severe form of sleep-disordered breathing (SDB) that is strongly correlated with comorbidities, in which epiglottic collapse (EC) and other contributing factors are involved. Objectives To evaluate the occurrence of EC in OSA patients through drug-induced sleep endoscopy (DISE) and to determine the factors contributing to EC. Methods A retrospective study of 37 adult patients using medical history. Patients were assessed for laryngopharyngeal reflux (LPR) and lingual tonsil hypertrophy (LTH) using reflux symptom index and reflux finding score (RFS); for OSA using polysomnography, and for airway collapse through DISE. An independent t-test was performed to evaluate risk factors, including the involvement of three other airway structures. Results Most EC patients exhibited trap door epiglottic collapse (TDEC) (56.8%) or pushed epiglottic collapse (PEC) (29.7%). Lingual tonsil hypertrophy, RFS, and respiratory effort-related arousal (RERA) were associated with epiglottic subtypes. Laryngopharyngeal reflux patients confirmed by RFS (t(25) = −1.32, p = 0.197) tended to suffer PEC; LTH was significantly associated (X2(1) = 2.5, p = 0.012) with PEC (odds ratio [OR] value = 44) in grades II and III LTH patients; 11 of 16 TDEC patients had grade I LTH. Pushed epiglottic collapse was more prevalent among multilevel airway obstruction patients. A single additional collapse site was found only in TDEC patients. Conclusion Laryngopharyngeal reflux causes repetitive acid stress toward lingual tonsils causing LTH, resulting in PEC with grade II or III LTH. Trap door epiglottic collapse requires one additional structural collapse, while at least two additional collapse sites were necessary to develop PEC. Respiratory effort-related arousal values may indicate EC. (OSA sleepdisordered disordered SDB (SDB comorbidities (EC involved druginduced drug induced DISE (DISE 3 history LPR (LPR (LTH (RFS) polysomnography ttest t test structures (TDEC 56.8% 568 56 8 (56.8% (PEC 29.7%. 297 29.7% . 29 7 (29.7%) effortrelated effort related RERA (RERA subtypes t25 25 (t(25 132 1 32 −1.32 0.197 0197 0 197 X21 X X2 (X2(1 2 5 2.5 0.012 0012 012 odds OR [OR 44 (RFS 56.8 (56.8 29.7 (29.7% t2 (t(2 13 −1.3 0.19 019 19 (X2( 2. 0.01 001 01 4 56. (56. 29. (29.7 (t( −1. 0.1 (X2 0.0 00 (56 (29. (t −1 0. (X (5 (29 − ( (2

Abstract Introduction Dysphagia induced by radiotherapy in the head and neck region comprises a challenging scenario and sometimes difficult rehabilitation due to the severity of the adverse effects. Some resources such as electrical stimulation have emerged as an alternative to complement the therapeutic process, but there is still no consensus on its use. Objective The purpose of the present study was to evaluate, through a meta-analysis, the effect of electrical stimulation on the rehabilitation of dysphagia generated after head and neck cancer treatment. Data Synthesis Four randomized controlled trials with a total of 146 participants were included. The age of the participants was 58.37 ± 1.8 years old and there was a predominance of males. The time to start the intervention ranged from 50.96 ± 40.12 months after cancer treatment. The intervention showed great heterogeneity regarding the positioning of the electrodes, parameters, duration of the stimulus, number of sessions, and intensity. No difference was identified in the following aspects: oral transit time, hyoid elevation, penetration and/or aspiration after electrostimulation. The quality of the evidence ranged from very low to moderate and high risk of bias. Conclusion In this meta-analysis, we found weak evidence for small and moderate swallowing benefits in patients after radiotherapy for head and neck cancer in short-term clinical trials. effects process use evaluate metaanalysis, metaanalysis meta analysis, analysis meta-analysis treatment 14 included 5837 58 37 58.3 18 1 8 1. males 5096 50 96 50.9 4012 40 12 40.1 electrodes parameters stimulus sessions intensity aspects elevation andor or electrostimulation bias shortterm short term 583 5 3 58. 509 9 50. 401 4 40.

Abstract Introduction Hearing impairment is one of the main disorders that can interfere with the development of speech and language. In an individual, it can cause significant communication difficulties, social isolation, negative feelings, and depressive disorders. The hearing aids (HAs) and cochlear implant (CI) are options for profound and severe hearing loss, and the CI can be indicated for individuals who do not obtain benefits from HAs. Objective To evaluate the quality of life of individuals who underwent sequential bilateral CIs with a long surgical interval between procedures. Methods Fifteen patients, aged 8 to 70 years old, who underwent sequential bilateral CI, with an interval ≥ 4 years between surgeries, were evaluated. Quality of life was evaluated using three questionnaires: WHOQOL-BREF, SSQ-12 and HHIA in Portuguese. Results The WHOQOL-BREF questionnaire showed that the study participants had a good quality of life in all domains assessed. According to the SSQ-12, few reported inability to listen in communication situations. Most individuals were classified as having medium disability by the HHIA, but the social and emotional effects did not significantly affect the quality of life. Conclusion The use of questionnaires to assess the quality of life of patients with hearing impairment is a valuable tool to measure adaptation to CI. Patients undergoing bilateral sequential CI, even with a long interval between procedures, presented high indices of quality of life. language individual difficulties isolation feelings HAs (HAs (CI loss procedures 7 old surgeries WHOQOLBREF, WHOQOLBREF WHOQOL BREF, BREF SSQ12 SSQ 12 SSQ-1 Portuguese assessed SSQ12, 12, situations SSQ1 1 SSQ-

Abstract Introduction Appropriate quality and quantity of sleep are critical for good mental health, optimal body functioning, memory consolidation, and other cognitive processes. Objectives To evaluate the sleeping patterns of medical students in Saudi Arabia and their relationships with psychological distress. Methods This was a cross-sectional, self-administered, questionnaire-based study. The study included medical students from a university in Jeddah, Saudi Arabia. The Pittsburgh Sleep Quality Index (PSQI) and the Athens Insomnia Scale (AIS) were used to evaluate the prevalence and burden of inadequate sleep quality and insomnia in the participants. Results The majority of the participants was women (76.6%). Furthermore, most participants (96.2%) were aged between 18 and 24 years old, while 54.4% of the participants were in their senior year. According to the AIS scores (mean: 15.85 ± 4.52), 98.7% of the participants exhibited insomnia symptoms. The PSQI scores (mean: 9.53 ± 5.67) revealed that 70.5% of the participants had poor sleep quality. Students in their fundamental and junior years had significantly higher percentages of insomnia symptoms and poor sleep quality compared with students in their senior years. Conclusion The prevalence of insomnia and poor sleep quality is high among medical students. Therefore, appropriate strategies for early detection and intervention are warranted. health functioning consolidation processes distress crosssectional, crosssectional cross sectional, sectional cross-sectional selfadministered, selfadministered self administered, administered self-administered questionnairebased questionnaire based Jeddah (PSQI (AIS 76.6%. 766 76.6% . 76 6 (76.6%) Furthermore 96.2% 962 96 2 (96.2% 1 old 544 54 4 54.4 year mean (mean 1585 15 85 15.8 4.52, 452 4.52 , 52 4.52) 987 98 7 98.7 953 9 53 9.5 5.67 567 5 67 705 70 70.5 Therefore warranted 76.6 (76.6% 96.2 (96.2 54. 158 8 15. 45 4.5 98. 95 9. 5.6 56 70. 76. (76.6 96. (96. 4. 5. (76. (96 (76 (9 (7 (

Abstract Introduction The criteria for the removal of the tracheostomy tube (decannulation) vary from center to center. Some perform an endoscopic evaluation under anesthesia or computed tomography, which adds to the cost and discomfort. We use a simple two-part protocol to determine the eligibility and carry out the decannulation: part I consists of airway and swallowing assessment through an office-based flexible laryngotracheoscopy, and part II involves a tracheostomy capping trial. Objective The primary objective was to determine the safety and efficacy of the simplified decannulation protocol followed at our center among the patients who were weaned off the mechanical ventilator and exhibited good swallowing function clinically. Methods Of the patients considered for decannulation between November 1st, 2018, and October 31st, 2020, those who had undergone tracheostomy for prolonged mechanical ventilation were included. The efficacy to predict successful decannulation was calculated by the decannulation rate among patients who had been deemed eligible for decannulation in part I of the protocol, and the safety profile was defined by the protocol's ability to correctly predict the chances of risk-free decannulation among those submitted to part II of the protocol. Results Among the 48 patients included (mean age: 46.5 years; male-to-female ratio: 3:1), the efficacy of our protocol in predicting the successful decannulation was of 87.5%, and it was was safe or reliable in 95.45%. Also, in our cohort, the decannulation success and the duration of tracheotomy dependence were significantly affected by the neurological status of the patients. Conclusion The decannulation protocol consisting of office-based flexible laryngotracheoscopy and capping trial of the tracheostomy tube can safely and effectively aid the decannulation process. (decannulation tomography discomfort twopart two officebased office based clinically 1st st 2018 31st 2020 protocols s riskfree risk free 4 mean age 465 46 5 46. years maletofemale male female ratio 31, 31 3 1 , 3:1) 875 87 87.5% 9545 95 45 95.45% Also cohort process 201 202 3:1 8 87.5 954 9 95.45 20 3: 87. 95.4 2 95.

Abstract Introduction Cricothyrotomy, percutaneous dilation tracheostomy, and tracheostomy are all cost-effective and safe techniques used in the management of critically ill patients who need an artificial airway other than endotracheal tube ventilation. The present study focused on enlightening on elective and emergency procedures performed on conditions present with difficult airways and also attempts to shed light on the aspects of securing an airway in anticipated and unanticipated difficult intubation. Objective The objective of the study was to compare the three procedures conducted during difficult airway/failed intubation situations. Methods The present retrospective observational study was conducted collecting data from patient files obtained at a tertiary healthcare center from 2013 to 2018. The difficult intubation cases were managed by ear, nose, and throat (ENT) surgeons. The study compared three methods: Cricothyrotomy, percutaneous dilation tracheostomy, and tracheostomy based on factors such as procedure duration, complications, and the instruments required for each procedure. Results The study enrolled 85 patients, 61 males and 24 females, aged between 30 and 70 years old. To perform cricothyrotomy, only a simple blade was required. Cricothyrotomy had the shortest operating time (4.1±3.1 minutes) and the shortest time of full oxygen saturation (3 min). Percutaneous tracheostomy had the least amount of bleeding (1%). Cricothyrotomy significantly showed the least intraoperative bleeding than percutaneous dilation, tracheostomy, and tracheostomy (p = 0.001). Conclusion Cricothyrotomy is preferable as it takes less time to perform, causes less bleeding, and takes the least time for full oxygen saturation than tracheostomy and percutaneous dilatational tracheostomy in "can't intubate, can't oxygenate" patients. costeffective cost effective ventilation airwayfailed failed situations 201 2018 ear nose ENT (ENT surgeons methods duration complications 8 6 2 females 3 7 old cricothyrotomy 4.1±3.1 4131 4 1 (4.1±3. minutes ( min. min . min) 1%. 1% (1%) p 0.001. 0001 0.001 0 001 0.001) cant can t intubate oxygenate 20 4.1±3. 413 (4.1±3 (1% 000 0.00 00 4.1±3 41 (4.1± (1 0.0 4.1± (4.1 0. 4.1 (4. 4. (4

Abstract Introduction Lateral pharyngoplasty (LP) has shown promising results. Craniofacial deformity reduces the pharyngeal space, contributing to the etiopathogenesis. The analysis of craniofacial features can be performed using cephalometry. Objective To verify if craniofacial deformity is associated with worse polysomnographic data in patients with obstructive sleep apnea (OSA), and to verify if the preoperative cephalometric parameters can interfere with the surgical success of the LP. Methods The study included 21 patients with OSA aged between 18 and 65 years who underwent LP in a university hospital from 2015 to 2019. Polysomnography was performed postoperatively, after a minimum period of 6 months from the surgical procedure. In addition, a cephalometric evaluation was performed to assess craniofacial deformity, and to correlate it with the polysomnographic results. Results The mean and median of all polysomnographic respiratory parameters improved postoperatively, especially the apnea-hypopnea index (AHI), which went from 40.15 to 16.60 events per hour (p = 0.001). Of the 21 patients, 15 showed improvements in the AHI postoperatively. As for the cephalometric evaluations, we found that the longer the distance between the hyoid bone and the mandibular plane, the greater the patient's preoperative AHI (p = 0.011). When assessing whether cephalometric changes related to craniofacial deformities influence the surgical outcome of LP, no correlation was found for any cephalometric measurement. Conclusion The longer the distance between the hyoid bone and the mandibular plane, the greater the preoperative AHI, and LP was an effective OSA treatment. Cephalometric variables are not able to modify or determine the success of LP in apneic patients in the population assessed. (LP results space etiopathogenesis cephalometry OSA, , (OSA) 2 1 201 2019 postoperatively procedure addition apneahypopnea hypopnea (AHI) 4015 40 40.1 1660 16 60 16.6 p 0.001. 0001 0.001 . 0 001 0.001) evaluations plane patient s 0.011. 0011 0.011 011 0.011) measurement treatment assessed (OSA 20 (AHI 401 4 40. 166 16. 000 0.00 00 0.01 01 0.0 0.

Abstract Introduction The early geneticist and psychiatrist Ernst Rüdin (1874–1952) became one of the key figures in the eugenics movement and in the German health system of the Nazi era. His connections in the international eugenics network have played an important role in the history of eugenics. Objective To discuss the connections between Ernst Rüdin's scientific group in Munich and Otmar von Verschuer's group in Frankfurt during the Nazi era. Methods Otorhinolaryngological materials from Ernst Rüdin's former private library are presented, and they show Rüdin's deep involvement in the international eugenics network. These materials provide insights into early medical genetics in otorhinolaryngology. Results One result of the present study is that eugenics groups from Munich, Frankfurt, and New York certainly influenced one another in the field of otorhinolaryngology. Karlheinz Idelberger and Josef Mengele were two scientists who performed hereditary research on orofacial clefts. Later, Mengele became deeply involved in Nazi medical crimes. His former work on orofacial clefts clearly had, to some extent, an influence on subsequent studies. Conclusion An international eugenics network already existed before 1933. However, it becomes clear that the weaknesses of many early genetic studies did not enable its authors to draw firm scientific conclusions, suggesting that scientists lacked an accurate concept of the genetic causes of most illnesses. 1874–1952 18741952 1874 1952 (1874–1952 era Rüdins s Verschuers Verschuer presented otorhinolaryngology Later crimes had extent 1933 However conclusions illnesses 1874–195 1874195 187 195 (1874–195 193 1874–19 187419 18 19 (1874–19 1874–1 18741 1 (1874–1 1874– (1874– (1874 (187 (18 (1 (

Abstract Introduction NB CE-Chirp LS was developed to improve the audiogram estimation by auditory brainstem response (ABR) thresholds during audiological assessment of infants and difficult to test children. However, before we know how the stimulus behaves in several types of hearing loss, it is important we know how the stimulus behaves in normal hearing infants. Objective To describe ABR thresholds with NB CE-Chirp LS stimulus for 500, 1,000, 2,000, and 4,000 Hz, as well as the amplitude and absolute latency for ABR thresholds. Methods Auditory brainstem response thresholds were evaluated with the Eclipse EP25 system. NB CE-Chirp LS was presented using an ER-3A insert earphone. EEG filter was 30 Hz high-pass and 1,500 Hz low-pass. The ABR threshold was defined as the lowest intensity capable of clearly evoke wave V, accompanied by an absent response 5 dB below. Results Eighteen normal hearing infants were evaluated. The mean and standard deviation (SD) of the ABR threshold (dB nHL) were: 23.8 (±4.2); 14.4 (±5.7); 6.0 (±5.0); and 7.0 (±5.9). The mean and SD of the absolute latency (ms) were: 8.86 (±1.12); 9.21 (±0.95); 9.44 (±0.78); and 9.64 (±0.52). The mean amplitude (nV) and SD were: 0.123 (±0.035); 0.127 (±0.039); 0.141 (±0.052); and 0.105 (±0.028), respectively, for 500, 1,000, 2,000 and 4,000 Hz. Conclusion Auditory brainstem response threshold with NB CE-Chirp LS reaches low levels, in special for high frequencies. It provides absolute latencies similar between frequencies with robust amplitude. The results obtained brings to the examiner more confidence in the results registered. CEChirp CE Chirp (ABR children However loss 500 1000 1 000 1,000 2000 2 4000 4 4,00 EP EP2 system ER3A ERA ER 3A A earphone 3 highpass pass 1500 1,50 lowpass. lowpass pass. low-pass V below (SD nHL 238 23 8 23. ±4.2 42 (±4.2) 144 14 14. ±5.7 57 7 (±5.7) 60 6 0 6. ±5.0 50 (±5.0) 70 7. ±5.9. 59 ±5.9 . 9 (±5.9) ms (ms 886 86 8.8 ±1.12 112 12 (±1.12) 921 21 9.2 ±0.95 095 95 (±0.95) 944 44 9.4 ±0.78 078 78 (±0.78) 964 64 9.6 ±0.52. 052 ±0.52 52 (±0.52) nV (nV 0123 123 0.12 ±0.035 0035 035 (±0.035) 0127 127 ±0.039 0039 039 (±0.039) 0141 141 0.14 ±0.052 0052 (±0.052) 0105 105 0.10 ±0.028, 0028 ±0.028 , 028 (±0.028) respectively 2,00 levels registered 100 00 1,00 200 400 4,0 150 1,5 ±4. (±4.2 ±5. (±5.7 (±5.0 (±5.9 88 8. ±1.1 11 (±1.12 92 9. ±0.9 09 (±0.95 94 ±0.7 07 (±0.78 96 05 ±0.5 (±0.52 012 0.1 ±0.03 003 03 (±0.035 (±0.039 014 ±0.05 005 (±0.052 010 10 002 ±0.02 02 (±0.028 2,0 1,0 20 40 4, 15 1, ±4 (±4. ±5 (±5. ±1. (±1.1 ±0. (±0.9 (±0.7 (±0.5 01 0. ±0.0 (±0.03 (±0.05 (±0.02 2, ± (±4 (±5 ±1 (±1. ±0 (±0. (±0.0 (± (±1 (±0 (

Abstract Introduction Dysphagia is a common issue in patients with head and neck cancer (HNC) and is known to negatively impact their quality of life. To evaluate the impact of dysphagia on the quality of life of HNC patients, the M. D. Anderson Dysphagia Inventory (MDADI) questionnaire was developed. Objective The present study aimed to culturally adapt and validate the MDADI for Persian-speaking individuals. The MDADI is a self-administered questionnaire designed to assess the impact of dysphagia on the quality of life of HNC patients. Methods The original MDADI questionnaire was translated into Persian using the forward-backward method, following the guidelines of the World Health Organization (WHO) for cultural adaptation. The content validity of the Persian version, MDADI-P, was assessed by 10 speech-language pathologists using the content validity index (CVI). Seventy-five HNC patients completed the MDADI-P to evaluate its convergent validity, which was determined by comparing the results with the Short-Form 36 (SF-36) questionnaire. Internal consistency and test-retest reliability were assessed using Cronbach α coefficient and intraclass correlation (ICC), respectively. Results The scale content validity index (S-CVI) for the MDADI-P was 0.90, indicating good content validity. The MDADI-P demonstrated satisfactory internal consistency (Cronbach α coefficient = 0.728) and test-retest reliability (ICC = 0.91). The total MDADI-P score exhibited a significant correlation with the physical and mental components of the SF-36 (0.456 and 0.349, respectively, p < 0.05). Conclusion The findings of the present study confirm the suitability of the MDADI-P in terms of content validity, construct validity, internal consistency, and test-retest reliability. (HNC M D (MDADI developed Persianspeaking speaking individuals selfadministered self administered forwardbackward forward backward method WHO (WHO adaptation version MDADIP, MDADIP P, P 1 speechlanguage speech language CVI. CVI . (CVI) Seventyfive Seventy five ShortForm Short Form 3 SF36 SF (SF-36 testretest test retest ICC, ICC , (ICC) respectively SCVI S (S-CVI 090 0 90 0.90 0.728 0728 728 0.91. 091 0.91 91 0.91) SF-3 0.456 0456 456 (0.45 0349 349 0.349 0.05. 005 0.05 05 0.05) (CVI SF3 (SF-3 09 9 0.9 0.72 072 72 SF- 0.45 045 45 (0.4 034 34 0.34 00 0.0 (SF- 0. 0.7 07 7 0.4 04 4 (0. 03 0.3 (SF (0 (