Abstract This study aims to scrutinize the disputes surrounding the ways of naming subjects who use the streets as their home in an attempt to understand the nuances of the nets of knowledge and power these historical classifications mobilize. Resorting to an extensive bibliographic, documentary survey and ethnographic research with subjects who inhabit the streets in their different interactions, this study historicizes the classifications attributed to these subjects - from the once vagrant, indigent, beggar to the current homeless situation - problematizing the different repressive and normalizing strategies that continue to affect this public, initiating forms of subjection and modes of resistance. Whether refusing classifications and their stigmas or denying housing as the only and primary political solution, these subjects enunciate other ways of being, living, and relating to the city, occupying other places, which we call “the third margin of institutions.”

Resumo O artigo busca perscrutar as lutas em torno dos modos de nomear os sujeitos que utilizam as ruas como morada, com intuito de perceber as sutilezas das redes de saber e poder que essas classificações históricas mobilizam. Recorrendo a um extenso levantamento bibliográfico e documental e à pesquisa etnográfica com os sujeitos que habitam as ruas, em suas diferentes interações, o texto historiciza as classificações atribuídas a esses sujeitos - do outrora vadio, indigente, mendigo ao presente integrante da população em situação de rua -, problematizando as diferentes estratégias repressivas e normalizadoras que continuam a recair sobre essas pessoas, encetando formas de assujeitamento, mas também modos de resistência. Quer recusando as classificações e seus estigmas, quer negando a moradia como única e primordial resposta política, esses sujeitos enunciam outros modos de ser, viver e se relacionar com a cidade, ocupando lugares outros, que chamamos aqui de “a terceira margem das instituições”.

ABSTRACT This article presents, analyzes, and discusses why and how one can think about the insertion of technology linked to science and computing for children aged 4 and 5 years old in early childhood education. The reflections presented here support the work carried out since 2018 by the Project Learning and Experimenting with Technology and Science in the Education of Children Aged 4 to 5 Years Old. It seeks to put aside the thought that reduces contact with technology to tablets, cell phones or even the assembly of robotics kits. In this sense, based on the fields of neuroscience and cultural historical theory to think about child development and by the concept of active user, i.e., one that uses and creates computer technologies in a critical, meaningful, reflective, and ethical way, we understand that technology involves all human creations that alter the natural, cultural, and social environment in which we find ourselves. We recognize the dangers for the development of children and the reductionism of children’s contact with technology and propose a work that does not disassociate science, mathematics, design, engineering, and computing centered on elements of children’s daily lives, built with hands-on learning.

RESUMO O presente artigo apresenta, analisa e discute por que e como pode se pensar a inserção da tecnologia atrelada às ciências e à computação para crianças de 4 e 5 anos na educação infantil. As reflexões aqui exibidas amparam o trabalho realizado desde 2018 no Projeto Aprendendo e Experimentando Tecnologia e Ciências na Educação de Crianças de 4 e 5 Anos. Procura-se deixar de lado o pensamento que reduz o contato com a tecnologia a tablets, celulares ou mesmo montagem de kits de robótica. Nesse sentido, calcados pelos campos da neurociência e da teoria histórico-cultural para pensar o desenvolvimento infantil e pelo conceito de usuário ativo, i.e., aquele que utiliza e cria tecnologias computacionais de forma crítica, significativa, reflexiva e ética, compreendemos que a tecnologia envolve todas as criações humanas que alteram os ambientes natural, cultural e social no qual nos encontramos. Reconhecemos os perigos para o desenvolvimento pleno das crianças que envolvem ao mesmo tempo o reducionismo operado no contato com a tecnologia e propomos um trabalho que não desvincule ciências, matemática, design, engenharia e computação centrado em elementos do cotidiano das crianças.

ABSTRACT Background: New-onset chronic pain has been acknowledged as part of the post-COVID-19 condition. However, available fine-grained data about its clinical phenotype, trajectories and main associated characteristics remain scarce. We described the distinct temporal evolutions of post-COVID-19 pain and their epidemiological and phenotypical features. Methods: A prospective cross-sectional study enrolled post-COVID-19 condition patients (i.e. who had persisting COVID-19-related symptoms over 30 days since their first positive laboratory test), whose COVID-19 diagnosis had been supported by RT-PCR of oral/nasopharyngeal swab or serology. They underwent in-person evaluations with a structured interview, pain and quality-of-life-related questionnaires and thorough physical examination. Chronic pain (CP) and probable neuropathic pain (NP) were defined according to IASP criteria. Results: The present study included 226 individuals, 177 (78.3 %) of whom presented over 3 months since their first COVID-19 symptom. New-onset pain occurred in 170 (75.2 %) participants and was chronic in 116 (68.2 %). A chronic course was associated with COVID-19-related hospitalization, new-onset fatigue, lower cognitive performance, motor and thermal sensory deficits, mood and sleep impairments and overall lower quality-of-life levels. Probable NP occurred in only 7.6 % new-onset pain patients, and was associated with pain chronification, new-onset fatigue, motor and thermal sensory deficits, mechanical allodynia and lower rates of SARS-CoV-2 vaccination. Previous CP was reported by 86 (38.1 %) individuals and had aggravated after the infection in 66 (76.7 %) of them, which was associated with orthostatic hypotension. Conclusions: Post-COVID pain phenomena follow different paths, which are associated with specific clinical and epidemiological features, and possibly distinct underlying mechanisms, prognostic and therapeutic implications. Significance: COVID-19-related pain usually follows a chronic course and is non-neuropathic. Its possible courses and phenotypes are associated with distinct clinical and epidemiological features. This suggests differing underlying mechnisms, which may have significant prognostic and therapeutic implications.

RESUMEN Antecedentes: El dolor crónico de nueva aparición se considera que forma parte de la condición o afección post-COVID-19. Sin embargo, los datos detallados existentes sobre el fenotipo clínico, las trayectorias y las principales características asociadas siguen siendo escasos. Describimos las distintas evoluciones temporales del dolor post-COVID-19 y sus rasgos epidemiológicos y fenotípicos. Métodos: Estudio prospectivo y transversal de pacientes con afección post-COVID-19 (es decir, con síntomas persistentes relacionados con la COVID-19 durante 30 días desde la primera prueba positiva de laboratorio) cuyo diagnóstico de COVID-19 estuviera basado en la RT-PCR de un frotis oral/nasofaríngeo o una serología. Se sometieron a evaluaciones presenciales mediante una entrevista estructurada, cuestionarios de dolor y calidad de vida y una exploración física exhaustiva. El dolor crónico (DC) y el dolor neuropático (DN) probablemente se definieron conforme a los criterios IASP. Resultados: El presente estudio incluyó 226 individuos, 177 (78,3 %) de los cuales se presentaron pasados más de 3 meses desde el primer síntoma de COVID-19. Tenían dolor de nueva aparición 170 (75,2 %) de los participantes y dolor crónico 116 (68,2 %). El curso crónico se asociaba a hospitalización por COVID-19, fatiga de nueva aparición, menor rendimiento cognitivo, déficits motores y sensitivos térmicos, alteraciones del ánimo y el sueño, y niveles generalmente inferiores de calidad de vida. El DN probable afectaba a solo el 7,6 % de los pacientes con dolor de nueva aparición y se asociaba a cronificación del dolor, fatiga de nueva aparición, déficits motores y de sensación térmica, alodinia mecánica y tasas menores de vacunación frente al SARS-CoV-2. Referían DC previo 86 (38,1 %) individuos, y este había empeorado tras la infección en 66 (76,7 %) de ellos, lo que se asociaba a hipotensión ortostática. Conclusiones: Los fenómenos dolorosos post-COVID siguen diferentes trayectorias que se asocian a rasgos clínicos y epidemiológicos específicos, y posiblemente a distintos mecanismos de base y diferentes implicaciones pronósticas y terapéuticas. Significado: El dolor relacionado con la COVID-19 sigue normalmente un curso crónico y no es neuropático. Los posibles cursos y fenotipos se asocian a rasgos clínicos y epidemiológicos distintos. Esto sugiere que los mecanismos de base difieren, lo que podría tener implicaciones pronósticas y terapéuticas importantes.

ABSTRACT BACKGROUND: Occult hepatitis B virus infection (OBI) is defined as the presence of hepatitis B virus (HBV) deoxyribonucleic acid (DNA) in the liver of individuals with undetectable hepatitis B virus surface antigen (HBsAg) in the serum. The actual prevalence of OBI and its clinical relevance are not yet fully understood. OBJECTIVE: To evaluate the prevalence of HBV DNA in liver biopsies of HBsAg-negative patients with chronic liver disease of different etiologies in a referral center in Brazil and compare two different HBV DNA amplification protocols to detect HBV. DESIGN AND SETTING: This cross-sectional observational study was conducted at the Liver Outpatient Clinic, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil, between January 2016 and December 2019. METHODS: HBV DNA was investigated in 104 liver biopsy samples from individuals with chronic liver disease of different etiologies, in whom HBsAg was undetectable in serum by nested-polymerase chain reaction (nested-PCR), using two different protocols. RESULTS: OBI, diagnosed by detecting HBV DNA using both protocols, was detected in 6.7% of the 104 individuals investigated. Both protocols showed a good reliability. CONCLUSION: In addition to the differences in the prevalence of HBV infection in different regions, variations in the polymerase chain reaction technique used for HBV DNA amplification may be responsible for the large variations in the prevalence of OBI identified in different studies. There is a need for better standardization of the diagnostic methods used to diagnose this entity.

ABSTRACT Objective: To describe the elaboration and content validity stages of a digital educational technology for nursing professionals about Japanese bathtub (ofurô) in newborns in neonatal care units. Method: A methodological study conducted between August 2019 and July 2021, in a public maternity hospital in Manaus, Amazonas, developed in two stages. In the first, the e-book images, text and editing were produced. In the second, material content validity was carried out, through the opinion of 15 expert judges, nurses and neonatal care experts. In data analysis, the percentage of agreement was applied with agreement score estimation. Items with 80% or more agreement were considered valid. Results: The e-book “Japanese bathtub: manual for nursing professionals” was produced, organized into nine sessions, which describe the technique execution. Content was considered valid by expert judges (general score 90%). Conclusion: The e-book was considered suitable for use in training nursing professionals, with potential for dissemination of knowledge regarding humanization of care for premature babies.

RESUMEN Objetivo: Describir las etapas de elaboración y validación de contenido de una tecnología educativa digital para profesionales de enfermería sobre el baño ofurô en recién nacidos en Unidades de Cuidados Neonatales. Método: Estudio metodológico realizado entre agosto de 2019 y julio de 2021, en una maternidad pública de Manaus, Amazonas, desarrollado en dos etapas. En la primera se produjeron las imágenes, el texto y la edición del e-book. En el segundo, se realizó la validación de contenido del material, a través de la expresión de 15 jueces expertos, enfermeros y experimentados en cuidados neonatales. En el análisis de datos se aplicó el porcentaje de concordancia con estimación del puntaje de concordancia. Se consideraron válidos los ítems con un 80% o más de acuerdo. Resultados: Se elaboró el libro electrónico “Banho de ofurô: manual para profissionais de enfermagem” (Baño de Ofurô: manual para profesionales de enfermería), organizado en nueve sesiones, que describen la ejecución de la técnica. El contenido fue considerado válido por los jueces expertos (puntuación general 90%). Conclusión: El e-book se consideró apto para ser utilizado en la formación de profesionales de enfermería, con potencial para la difusión de conocimientos sobre la humanización del cuidado del recién nacido prematuro.

RESUMO Objetivo: Descrever as etapas de elaboração e validação de conteúdo de uma tecnologia educacional digital para profissionais de enfermagem sobre o banho de ofurô em recém-nascidos em Unidades de Cuidado Neonatal. Método: Estudo metodológico conduzido entre agosto de 2019 e julho de 2021, em uma maternidade pública de Manaus, Amazonas, desenvolvido em duas etapas. Na primeira, foram produzidas as imagens, texto e editoração do e-book. Na segunda, foi conduzida a validação de conteúdo do material, pela manifestação de 15 juízes especialistas, enfermeiros e experientes no cuidado neonatal. Na análise dos dados, aplicou-se a porcentagem de concordância com estimação de escore de concordância. Foram considerados válidos os itens com 80% ou mais de concordância. Resultados: Foi produzido o e-book “Banho de ofurô: manual para profissionais de enfermagem”, organizado em nove sessões, que descrevem a execução da técnica. O conteúdo foi considerado válido pelos juízes especialistas (escore geral 90%). Conclusão: O e-book foi considerado adequado para ser utilizado em treinamento de profissionais de enfermagem, com potencial para a difusão do conhecimento quanto à humanização da assistência ao recém-nascido prematuro.

ABSTRACT: Strawberry is one of the most socially and economically important small fruits in Brazil, with strong demand by the food industry driving high levels of production. However, phytosanitary problems, especially insect damage, can hamper strawberry cultivation. A pest of great concern is the strawberry sap beetle, Lobiopa insularis (Coleoptera: Nitidulidae), which damages the fruits. Chemical control has not been effective against L. insularis, as it makes harvesting and marketing the product unfeasible. Parasitoids have been effectively utilized to control various strawberry pests and support sustainable production. We report the occurrence of the wasp Cerchysiella insularis (Hymenoptera: Encyrtidae) as a parasite of L. insularis on strawberries in São José dos Pinhais, Paraná, Brazil. Samples of strawberries (San Andreas cultivar) attacked by L. insularis were collected from February to March, 2019. Lobiopa insularis larvae were individually placed in rearing pots, fed on San Andreas strawberries, and checked weekly for symptoms of parasitism or parasitoid emergence. Parasitism rates were 33.85% in March and 45.90% in February. The sex ratio varied between 0.88 and 0.86. All parasitized larvae were infested by C. insularis. The natural parasitism rate above 33% and high sex ratio of C. insularis in strawberry crops indicated that it may have the potential in the control of L. insularis.

RESUMO: O morango é uma das pequenas frutas de maior importância social e econômica no Brasil, com forte demanda pela indústria alimentícia, o que impulsiona altos níveis de produção. No entanto, problemas fitossanitários, principalmente danos causados por insetos, podem dificultar o cultivo do morango. Uma praga de grande preocupação é a broca do morangueiro, Lobiopainsularis (Coleoptera: Nitidulidae), que danifica os frutos. O controle químico não tem sido eficaz contra L. insularis, pois inviabiliza a colheita e comercialização do produto. Os parasitoides têm sido efetivamente utilizados para controlar várias pragas de morangueiro, em um sistema de produção sustentável. Relatamos a ocorrência da vespa Cerchysiella insularis (Hymenoptera: Encyrtidae) como parasita de L. insularis em morangos em São José dos Pinhais, Paraná, Brasil. Amostras de morangos (cultivar San Andreas), atacados por L. insularis, foram coletadas durante o período de fevereiro a março de 2019. As larvas de L. insularis foram colocadas individualmente em vasos de criação, alimentadas com morangos San Andreas e verificadas semanalmente quanto aos sintomas de parasitismo e à emergência de parasitoides de C. insularis. As taxas de parasitismo de C. insularis foram de 33,85%, em março, e 45,90%, em fevereiro. A razão sexual variou entre 0,88 e 0,86. Todas as larvas parasitadas estavam infestadas por C. insularis. A taxa de parasitismo natural acima de 33% e alta razão sexual de C. insularis em cultivos de morangueiro indicam que este parasitoide pode ter potencial no controle de L. insularis.

Abstract This study aimed to verify the impact of high-fat diet consumption for a prolonged period on oxidative stress, fetal growth, umbilical vascular system, and placental structures in pregnant goats. Twenty-two pregnant goats were grouped into the control diet (n= 11) and fat diet (n = 11). Flaxseed meal was added to the fat diet, replacing the corn grain of concentrate, from gestational day 100 to delivery date. Diets were isonitrogenous and isoenergetic, differing in fat content (2.8% vs. 6.3% dry matter). The fat group showed higher feed intake and total plasma lipid levels than the control group (P < 0.001). No difference was found in placentome, and umbilical vascular development. Fat diet-fed goats exhibited a lower systolic peak in the umbilical artery. At delivery, placental traits were similar with the exception of the cotyledon width (P = 0.0075), which was smaller in the fat group and cotyledon surface (P = 0.0047) for multiple pregnancy of fat diet. Cotyledonary epithelium showed more intense staining of lipid droplets and a greater area for lipofuscin staining in the fat group compared to control group (P < 0.001). The mean live weight of the kids was lower in the fat group in the first week after delivery than in control group. Thus, in goats, the continuous administration of a high-fat diet during pregnancy does not appear to modify the fetal-maternal vascular structures but has an impact on a part of the placental structure; therefore, its use must be carefully evaluated.

ABSTRACT Objective: To assess the outcome of extubation in COVID-19 patients and the use of noninvasive ventilation in the weaning process. Methods: This retrospective, observational, single-center study was conducted in COVID-19 patients aged 18 years or older who were admitted to an intensive care unit between April 2020 and December 2021, placed under mechanical ventilation for more than 48 hours and progressed to weaning. Early extubation was defined as extubation without a spontaneous breathing trial and immediate use of noninvasive ventilation after extubation. In patients who underwent a spontaneous breathing trial, noninvasive ventilation could be used as prophylactic ventilatory assistance when started immediately after extubation (prophylactic noninvasive ventilation) or as rescue therapy in cases of postextubation respiratory failure (therapeutic noninvasive ventilation). The primary outcome was extubation failure during the intensive care unit stay. Results: Three hundred eighty-four extubated patients were included. Extubation failure was observed in 107 (27.9%) patients. Forty-seven (12.2%) patients received prophylactic noninvasive ventilation. In 26 (6.8%) patients, early extubation was performed with immediate use of noninvasive ventilation. Noninvasive ventilation for the management of postextubation respiratory failure was administered to 64 (16.7%) patients. Conclusion: We found that COVID-19 patients had a high rate of extubation failure. Despite the high risk of extubation failure, we observed low use of prophylactic noninvasive ventilation in these patients.

RESUMO Objetivo: Avaliar o desfecho da extubação em pacientes com COVID-19 e o uso da ventilação não invasiva no processo de desmame. Métodos: Este estudo retrospectivo, observacional e unicêntrico foi realizado em pacientes com COVID-19 com 18 anos ou mais, internados em uma unidade de terapia intensiva entre abril de 2020 e dezembro de 2021, colocados sob ventilação mecânica por mais de 48 horas com progressão para o desmame. A extubação precoce foi definida como a extubação sem um teste de ventilação espontânea e com uso imediato de ventilação não invasiva após a extubação. Em pacientes submetidos a um teste de ventilação espontânea, a ventilação não invasiva poderia ser usada como assistência ventilatória profilática, quando iniciada imediatamente após a extubação (ventilação não invasiva profilática), ou como terapia de resgate em casos de insuficiência respiratória pós-extubação (ventilação não invasiva terapêutica). O desfecho primário foi falha de extubação durante a internação na unidade de terapia intensiva. Resultados: Foram incluídos 384 pacientes extubados. A falha de extubação foi observada em 107 (27,9%) pacientes. Quarenta e sete (12,2%) pacientes receberam ventilação não invasiva profilática. Em 26 (6,8%) pacientes, a extubação precoce foi realizada com o uso imediato de ventilação não invasiva. A ventilação não invasiva para o manejo da insuficiência respiratória pós-extubação foi administrada em 64 (16,7%) pacientes. Conclusão: Os pacientes com COVID-19 apresentaram alta taxa de falha de extubação. Apesar do alto risco de falha de extubação, observamos baixo uso de ventilação não invasiva profilática nesses pacientes.

Abstract Recent advances in genome editing have enormously enhanced the effort to develop biotechnology crops for more sustainable food production. CRISPR/Cas, the most versatile genome-editing tool, has shown the potential to create genome modifications that range from gene knockout and gene expression pattern modulations to allele-specific changes in order to design superior genotypes harboring multiple improved agronomic traits. However, a frequent bottleneck is the delivery of CRISPR/Cas to crops that are less amenable to transformation and regeneration. Several technologies have recently been proposed to overcome transformation recalcitrance, including HI-Edit/IMGE and ectopic/transient expression of genes encoding morphogenic regulators. These technologies allow the eroding of the barriers that make crops inaccessible for genome editing. In this review, we discuss the advances in genome editing in crops with a particular focus on the use of technologies to improve complex traits such as water use efficiency, drought stress, and yield in maize. production CRISPRCas CRISPR Cas genomeediting tool allelespecific allele specific However regeneration recalcitrance HIEdit/IMGE HIEditIMGE HI Edit/IMGE Edit IMGE ectopictransient ectopic transient regulators review efficiency stress maize HIEdit EditIMGE

Abstract Anthropogenic disturbances affecting forest areas can increase disease prevalence and susceptibility in several species of arboreal mammals, such as sloths. Thus, this study aimed to evaluate the most common conditions in body systems of free-ranging sloths admitted at the Wildlife Triage and Rehabilitation Center of Amazonas of the Institute of Environment and Renewable Natural Resources. A total of 227 individuals (139 retrospective cases from 2015 to 2019, and 88 prospective cases from July 2020 to July 2021) were evaluated over a six-year period. Cases from the genus Bradypus showed involvement of the following body systems: 44% respiratory, 29% integumentary, 15% musculoskeletal, 5% digestive, 3% visual, 2% auditory, 1% circulatory and 1% genitourinary, while that distribution in the genus Choloepus was: 39% musculoskeletal, 27% integumentary, 19% respiratory, 9% digestive, 3% circulatory, 1% visual, 1% auditory and 1% genitourinary. The results reveal significant differences between the condition detected and the genus (Bradypus and Choloepus), age and case outcome. These results can provide data for future investigations of sloth diseases, confirming lesions, as well as motivating and suggesting adequate management methods.

Resumo Distúrbios antrópicos que afetam áreas florestais podem aumentar a prevalência de afecções e a suscetibilidade às doenças em diversas espécies de mamíferos arborícolas, como as preguiças. Desta forma, este estudo teve como objetivo avaliar as condições mais comuns nos sistemas orgânicos de preguiças de vida livre admitidas no Centro de Triagem e Reabilitação de Animais Silvestres do Amazonas. Um total de 227 indivíduos (139 casos retrospectivos de 2015 a 2019 e 88 casos prospectivos de julho de 2020 a julho de 2021) foram avaliados durante um período de seis anos. Para o gênero Bradypus foram diagnosticadas 44% de afecções do sistema respiratório, 29% tegumentar, 15% musculoesquelético, 5% digestório, 3% visual, 2% auditivo, 1% circulatório e 1% genitourinário. Por sua vez, para o gênero Choloepus foram detectadas 39% de afecções do sistema musculoesquelético, 27% tegumentar, 19% do sistema respiratório, 19% do sistema respiratório, 9% digestório, 3% circulatório, 1% visual, 1% auditivo e 1% genitourinário. Os resultados mostraram diferenças significativas na prevalência da afecção e gênero das preguiças (Bradypus e Choloepus), a faixa etária e desfecho do caso. Esses resultados podem fornecer subsídios para investigar as doenças de preguiças, confirmando afecções, motivo e sugerir métodos adequados de manejo.

Abstract This study aimed to investigate the effect of a short glutamate supply on the ovarian response in goats with low body condition scores. Twenty-one goats had their estrus and follicular waves synchronized using three injections of prostaglandin analog at seven-day intervals. Goats were allocated to groups receiving 10 mg/kg LW (iv) of glutamate administered in a single dose (group LBCG1, n = 7) or in two doses five days apart (group LBCG2, n = 7). The control group (LBC; n = 7) received saline solution. Glutamate treatment did not affect glucose, cholesterol, or glutathione peroxidase levels, body weight, or adipose deposits. During the experimental period, the LBCG2 group showed a higher (P < 0.05) number of follicles (> 3 mm) and an increase in follicle diameter (P < 0.05). Glutamate supply improved (P < 0.05) the intraovarian Doppler blood area size in the LBCG groups, and the second dose in LBCG2 also induced a higher (P < 0.05) systolic and diastolic peak of the ovary artery. After ovulation induction, LBCG2 exhibited a high (P < 0.05) volume of the corpus luteum and vascularized area. We concluded that the supply of two doses of glutamate five days apart was efficient in ovarian stimulation in goats with a low body condition.

Resumo O objetivo do artigo consiste em pensar o trabalho doméstico remunerado no Brasil em meio à crise pandêmica associada ao novo coronavírus, à luz de perspectivas teóricas que reposicionam, sobre novas bases epistêmicas, as intersecções das opressões de classe, gênero e raça enquanto elementos estruturantes do sistema capitalista. Dados estatísticos mostram o impacto da Covid-19 e da crise econômica subsequente no aprofundamento da desvalorização, precarização e no empobrecimento de trabalhadoras domésticas, em sua maioria mulheres negras, pouco escolarizadas e com baixo acesso a políticas sociais. A pandemia, em suas graves consequências tornou latentes as hierarquias raciais e de gênero, tributárias da experiência da colonialidade e da escravidão, prolongadas e mantidas em permanente reinvenção no contexto brasileiro. Por fim, o artigo, apoiando-se na proposição teórica inovadora de Nancy Fraser a respeito da categoria “expropriação”, propõe aplicá-la em combinação à noção de “reprodução social”, encetada pelo feminismo marxista há mais de quatro décadas, para situar o trabalho doméstico remunerado no encontro dessas duas “condições de possibilidade” do capitalismo contemporâneo.

Abstract The aim of this article is to think about paid domestic work in Brazil in the midst of the pandemic crisis associated with the new coronavirus, in light of theoretical perspectives that reposition, on new epistemic bases, the intersections of class, gender and race oppressions as structural elements of the capitalist system. Statistical data show the impact of Covid-19 and the subsequent economic crisis in deepening the devaluation, precariousness, and impoverishment of domestic workers, mostly black women with poor schooling and limited access to social policies. The pandemic, in its serious consequences, made latent racial and gender hierarchies tributaries of the experience of coloniality and slavery, prolonged and maintained in permanent reinvention in the Brazilian context. Finally, the article draws on Nancy Fraser’s innovative theoretical proposition about the category “expropriation”, proposing that it could be applied in combination with the notion of “social reproduction”, as conceived by Marxist feminism four decades ago to situate paid domestic work at the convergence of these two “conditions of possibility” of contemporary capitalism.

Resumo Fundamento Cerca de 40% dos pacientes com infarto agudo do miocárdio com supradesnível do segmento ST (IAMCSST) no Brasil não recebem terapia de reperfusão. Objetivo A utilização de uma rede de telemedicina baseada no WhatsApp® poderia aumentar a porcentagem de pacientes que recebem terapia de reperfusão. Métodos Estudo transversal do tipo antes e depois da organização de uma rede de telemedicina para envio e análise do eletrocardiograma através do WhatsApp® dos pacientes suspeitos de IAMCSST oriundos dos 25 municípios integrantes do Departamento Regional de Saúde de Ribeirão Preto (DRS−XIII), para hospital terciário que poderia autorizar a transferência imediata do paciente utilizando o mesmo sistema. O desfechos analisados foram a porcentagem de pacientes que receberam terapia de reperfusão e a taxa de mortalidade intra-hospitalar. Considerou-se valor de p <0,05 como estatisticamente significativo. Resultados Foram comparados 82 pacientes antes desta rede (1º de fevereiro de 2016 a 31 de janeiro de 2018) com 196 pacientes depois da implantação da mesma (1º de fevereiro de 2018 a 31 de janeiro de 2020). Após a implantação da rede, houve aumento significativo da proporção de pacientes que receberam terapia de reperfusão (60% vs. 92%), risco relativo (RR): 1,594 [intervalo de confiança (IC) 95% 1,331 – 1,909], p <0,0001 e redução da mortalidade intra-hospitalar (13,4% vs. 5,6%), RR: 0,418 [IC 95% 0,189 – 0,927], p = 0,028. Conclusão Rede de telemedicina baseada no WhatsApp® associou-se a aumento da porcentagem de pacientes com IAMCSST que receberam terapia de reperfusão e a redução na mortalidade intra-hospitalar.

Abstract Background About 40% of patients with ST-segment elevation myocardial infarction (STEMI) in Brazil do not receive reperfusion therapy. Objective The use of a telemedicine network based on WhatsApp® could increase the percentage of patients receiving reperfusion therapy. Methods A cross-sectional study analyzed outcomes before and after the organization of a telemedicine network to send the electrocardiogram via WhatsApp® of patients suspected of STEMI from 25 municipalities that are members of the Regional Health Department of Ribeirão Preto (DRS−XIII) to a tertiary hospital, which could authorize immediate patient transfer using the same system. The analyzed outcomes included the percentage of patients who received reperfusion therapy and the in-hospital mortality rate. A p value < 0.05 was considered statistically significant. Results The study compared 82 patients before (February 1, 2016 to January 31, 2018) with 196 patients after this network implementation (February 1, 2018 to January 31, 2020). After implementing this network, there was a significant increase in the proportion of patients who received reperfusion therapy (60% vs. 92%), relative risk (RR): 1.594 [95% confidence interval (CI) 1.331 – 1.909], p < 0.0001 and decrease in the in-hospital mortality rate (13.4% vs. 5.6%), RR: 0.418 [95%CI 0.189 – 0.927], p = 0.028. Conclusion The use of WhatsApp®-based telemedicine has led to an increase in the percentage of patients with STEMI who received reperfusion therapy and a decrease in the in-hospital mortality rate.

Abstract INTRODUCTION: Pancreatic cancer is increasing worldwide. The burden of pancreatic cancer in Brazil and its states was analyzed and compared with that from the USA and China. METHODS: This is a descriptive study of the incidence and mortality estimates from the Global Burden of Disease 2019 study, from 2000 to 2019. The Brazilian states presenting the highest and lowest socio-demographic index (SDI) were selected from each of the five regions. The SDI consists of the per capita income, education, and fertility rate of each population. RESULTS: A significant increase was found in age-standardized incidence and mortality of pancreatic cancer in all three countries, with differences in magnitude and annual increases. In Brazil, this incidence rose from 5.33 [95% Uncertainty Interval (UI): 5.06- 5.51] to 6.16 (95% UI: 5.68- 6.53) per 100,000 inhabitants. China and the Brazilian states with the lowest SDI, such as Pará and Maranhão, showed lower incidence and mortality rates, although presenting the highest annual increases. No difference was found between the sexes. A higher mortality rate was observed for those individuals of 70+ years, which was three to four times higher than those aged 50 to 69 years. CONCLUSIONS: The increasing burden of pancreatic cancer in the studied countries, and the higher estimates for the elderly in a fast-aging country such as Brazil, indicates that more resources and health policies will be necessary. The greatest increase in the states with lower SDI reflects inequalities in the access to diagnosis and registries of this cancer.

ABSTRACT. Ergot is a fungal disease and causes reductions in seed productivity and quality. We aimed to identify promising genotypes of brachiaria evaluating: (1) seed production potential (number of tillers, racemes per inflorescence, spikelets per raceme, raceme length, weight and number of seeds, and germination) and (2) resistance of seeds to Ergot (infected tillers, infected seeds). Five genotypes of Brachiaria grasses, four non-natural hybrids named BH1619, BH1810, BH1516 and Mavuno Palisadegrass (Urochloa brizantha x Urochloa ruziziensis), and Marandu Palisadegrass (U. brizantha Hoechst cv. Marandu) were evaluated. The BH1619 hybrid, despite the high weight of seeds, produced less viable, pure seeds. The hybrid BH1516 had a lower percentage of flowered tillers (42%) and seeds infected with ergot (8%). Marandu Palisadegrass had a higher percentage of infected tillers (95%) and infected seeds (38%). The hybrid BH1516 was the most resistant to ergot, followed by Mavuno Palisadegras sand BH1619. Among all materials, Mavuno Palisadegrass and BH1516 have a higher potential for seed production due to the higher percentage of flowered tillers and production of pure seeds with high germination capacity. The BH1516 hybrid was resistant to ergot, making it a better choice for use in infected areas used for seed or forage production.