Resumo Introdução: A traqueostomia é um procedimento cirúrgico comumente feito na prática otorrinolaringológica. O cuidado pós-operatório é o aspecto mais importante para alcançar bons resultados para o paciente. A indisponibilidade de diretrizes padrão para o manejo da traqueostomia e o treinamento inadequado podem tornar complexa essa prática básica. A equipe de enfermagem e os médicos desempenham um papel muito importante no manejo à beira do leito, tanto na enfermaria quanto na unidade de terapia intensiva (UTI). Portanto, é crucial que todos os profissionais de saúde diretamente envolvidos na prestação de cuidados pós-operatórios a esses pacientes possam fazer isso de forma eficiente. Objetivo: Avaliar o conhecimento sobre a identificação e manejo de emergências relacionadas à traqueostomia e complicações precoces entre os profissionais de saúde, a fim de melhorar a prática e sua padronização. Método: Estudo observacional transversal que incluiu 254 médicos e enfermeiras de quatro grandes hospitais terciários. As perguntas foram simples e diretas em relação à aspiração da traqueostomia, cuidados com o cuff, manejo do cuff, obstrução da cânula e manejo da alimentação em pacientes traqueostomizados. Resultado: Com base nas evidências de nosso estudo, o nível de conhecimento sobre os cuidados com a traqueostomia varia de 48% a 52%, com escores de conhecimento acima de 50% considerados satisfatórios. Existem lacunas significativas no conhecimento em vários aspectos dos cuidados e manejo da traqueostomia entre os profissionais de saúde. Conclusão: Nossos achados demonstraram um nível de conhecimento adequado entre os profissionais de saúde, variação de 48% a 52%, com escores de conhecimento acima de 50% considerados satisfatórios e revelaram que ainda existem lacunas no conhecimento em vários aspectos do tratamento e manejo do paciente traqueostomizado.

Abstract Introduction: Tracheostomy is commonly performed surgical procedure in ENT practice. Postoperative care is the most important aspect for achieving good patient outcomes. Unavailability of standard guidelines on tracheostomy management and inadequate training can make this basic practice complex. The nursing staff and doctors play a very important role in bedside management, both in the ward and in the intensive care unit (ICU) setup. Therefore, it is crucial that all healthcare providers directly involved in providing postoperative care to such patients can do this efficiently. Objectives: The objective of this study is to assess the knowledge regarding identification and management of tracheostomy-related emergencies and early complications among healthcare professionals so as to improve practice and further standardization. Methods: Cross-sectional observational study included two hundred and fifty-four doctors and nurses from four large tertiary care hospitals. The questions used were simple and straightforward regarding tracheostomy suctioning, cuff care, cuff management, tube blockage, and feeding management in patients with tracheostomy. Results: Based on evidence from our study, knowledge level regarding tracheostomy care ranges from 48% to 52% with knowledge scores above 50% being considered satisfactory. Significant gaps in knowledge exist in various aspects of tracheostomy care and management among healthcare professionals. Conclusion: Our findings demonstrated an adequate knowledge level among health care professionals ranging from 48% to 52% with knowledge scores above 50% being considered satisfactory and revealed that gaps in knowledge still exist in various aspects of tracheostomy care and management.

Abstract Milk is an excellent source of nutrients. It is a balanced diet. Cheeses are fermented milk product. There are hunderds of cheese types. Cottage cheese is fermented dairy product made by the coagulation of milk. It is nutritionally most suitable diet for lactose intolerant people. It contains all essential nutrients. Recently cottage cheese was made with the use of tatri and lemon juice. The use of tatri and lemon do not produce good quality end product. This project was aimed to standardize cottage cheese using food grade coagulants. Cottage cheese was analyzed for physicochemical, textural, functional and sensorial analysis. The use of food grade organic acids produced strong results. The increase in acid level increases the yield but it is not remains good organolaptically. Sensory results reveals that the use of acetic acid has a bitter aftertaste. The use of citric acid at the level of 0.4% was found best on all aspects.

Abstract Pesticides have emerged as a global threat to human health, especially in developing countries. In this study, we examined nine major types of pesticide residues in the food commodities (8 groups) and serum samples (n = 80) of people living in the region of Southern-Punjab, Pakistan. Pesticide residues quantification was performed using gas chromatograph coupled with electron capture detector (GC-ECD). The estimated daily intakes of the selected pesticide residues through consumption of food were also calculated. The concentration of analyzed pesticide residues in food was found below the EU maximum permissible limits except for α-HCH, and β-HCH. The highest risk of cancer was found to be associated with the consumption of HCHs contaminated cereals than other products. The incidence rate of pesticide residues in the serum samples of studied subjects was 96.25%. Pearson correlation test showed no significant correlation between thyroid hormone levels of the studied population group and the analyzed pesticide residues in the food commodities (p>0.05). Findings of this study indicate that people of Southern-Punjab, Pakistan are exposed to pesticides via food chain although non-significant health implications were recorded, the levels of a few pesticides need to be curtailed.

The study was designed to compare low and high levels of protein, namely 90 and 147 g/kg of dietary dry matter, and to evaluate the effect of concentrate proportions on the in situ digestion kinetics of neutral detergent fibre in buffaloes and cows fed a low protein diet at maintenance intake level. In the first experiment, heifers and lactating females were offered a high protein diet. In the second, the performances of buffaloes and cows were compared when fed diets with low and high proportions of concentrate at low dietary protein level. At higher protein supply, the heifers showed a 6% unit increase in neutral detergent fibre degradability (NDFD) compared with lactating animals. Similarly, at a higher level of concentrate proportion, an 8% unit increase was observed in NDFD. In both experiments the comparison of buffaloes and cows was non-significant for NDFD. Those data that were pooled against the stage of development of both experiments for protein levels depicted a 13% unit increase in NDFD at high protein level compared with low level. At maintenance intake level, a high dietary crude protein or concentrate supply improved the in situ NDFD of tropical forages in buffaloes and cows, owing to the enhanced intake of NDF from concentrate and better synchronization of protein and energy availability in the rumen.

Abstract Antioxidants are the body's defense system against the damage caused by reactive oxygen species, formed naturally during many physiological activities. In vegetables and fruits, various antioxidant compounds such as vitamin C, polyphenols, flavonoids, and carotenoids have been identified. Because fruits and vegetables are the primary antioxidant sources in our daily diet, it is necessary to determine their antioxidant capacity. Citrus fruit consumption per capita has steadily increased over the world over the last 30 years. Citrus fruits are high in vitamin C as well as other active ingredients like phenols and flavonoids that are beneficial to human health. Using carotenoid complement and pigmentation genetic diversity, the objective of this research was to see how vitamin C and carotenoids contributed to the capacity of hydrophilic antioxidants of the citrus fruits’ pulp. Six citrus cultivars were chosen for this purpose: two sweet orange genotypes, Valencia Ruby and Valencia Late; two grapefruit genotypes, Star Ruby and Marsh; and two mandarin genotypes, Nadorcott and Clemenules. In proportion to their color singularity, total carotenoid composition and content in fruit pulp differed dramatically. A good and clear connection was found between hydrophilic antioxidant capacity and vitamin C concentration in the pulp of various fruit species, as measured by DPPH and ABTS tests. The proportion of vitamin C to the total HAC was calculated to be between 15% and 30%.

ABSTRACT Objectives of the present study were to assess the hatchery based interventions and their impact on hatching traits and subsequent performance of broilers. In total, 3000 eggs of Hubbard broiler breeders were equally divided into Small (50-55 g), Medium (56-61 g) and Large (62-70 g) eggs. The eggs from each category were distributed into 20 trays each containing 50 eggs. Each tray was considered as a replicate. At the end of the 18th day of incubation, the eggs of each weight category were divided into four different patio strategies i.e. P0, P3, P5 and P7 where feed and water were provided to the chicks for 0, 3, 5 and 7 days in the hatcher followed by conventional rearing. Data were collected for hatch window, hatching traits, growth, physical asymmetry, welfare and blood profile in broilers. Statistical analysis showed that the smaller eggs had significantly (P<0.05) shorter hatch window compared to larger and medium eggs. Hatching traits were significantly (p<0.05) better in medium eggs but the embryonic mortalities did not differ (p>0.05). The post-hatch performance was significantly (p<0.05) better in P3 birds from medium eggs. Physical asymmetry and scores of feather and gait were not affected by both treatments (p>0.05). Blood profile was also significantly (p<0.05) better in P3 birds from medium-size eggs. It was recommended that the eggs of 56-61g should be selected for better hatchability and the chicks should be provided with feed and water within the hatcher for at-least three days for optimum performance on rearing facility.

Abstract The wheat variety NIA-Shaheen (CIM-04-10) has high grain yield and modern plant architecture. It has wide adaptability, increased tiller production, bold grains, high starch and protein content, and good tolerance to disease and environmental stresses, particularly water stress. NIA-Shaheen has high yield potential (7184 kg ha-1).

ABSTRACT The present study aimed to evaluate the influence of various levels of synbiotics on growth performance and intestinal morphology of fast-growing broilers during different phases. A total of 720, one-day-old straight run broilers (Ross 308) were randomly divided into 12 treatment groups according to a completely randomized design having three supplemented diets of synbiotics (a combination of probiotics and prebiotics) (0.5, 1, and 1.5%) reared at four phases [starter (1-11 days), grower (12-22 days), finisher (23-35 days), whole life (1-35 days)]. Every treatment was replicated six times with ten birds each. The parameters were evaluated in growth performance (feed intake, body weight, feed conversion ratio, and mortality) and intestinal morphology (Villus height, Crypt depth and Villus to Crypt ratio). Results of the present study revealed that growth performance, feed intake (p=0.0029), body weight (p=0.0001) and feed conversion ratio (p=0.0001) were improved with 1 percent synbiotics diet supplementation,while1.5 percent synbiotics level showed lower body weight. Crypt death (p=0.0529) has been marginally greater in the whole life. It can be inferred that a 1 % synbiotics supplemented diet has had a beneficial impact on growth and gut health throughout life.

Resumo Justificativa: Náusea e vômito no pós-operatório é a segunda queixa pós-operatória mais frequente após a dor. Sem profilaxia antiemética, a incidência de náusea e vômito no pós-operatório foi de 60−80% após cirurgia do ouvido médio. Dada a alta incidência relatada de náusea e vômito no pós-operatório, nosso objetivo foi avaliar o efeito da combinação de palonosetrona-dexametasona e ondansetrona-dexametasona na prevenção de náusea e vômito no pós-operatório em pacientes submetidos a cirurgia do ouvido médio. Método: Sessenta e quatro pacientes programados para cirurgia de ouvido médio foram aleatoriamente divididos em dois grupos. Um recebeu a combinação de palonosetrona-dexametasona (grupo P) e o outro ondansetrona-dexametasona (grupo O) por via intravenosa antes da indução anestésica. A técnica anestésica foi padronizada em todos os pacientes. No pós-operatório, foram registradas incidência e gravidade das náuseas e vômitos, necessidade de antiemético de resgate, efeitos colaterais e índice de satisfação dos pacientes. Resultados: As características demográficas foram semelhantes nos grupos estudados. A diferença na incidência de náusea foi estatisticamente significante entre os grupos O e P apenas no intervalo de tempo entre 2 e 6 horas (p = 0,026). A incidência e gravidade de vômito não foram estatisticamente significantes entre os grupos O e P durante todo o período do estudo. A incidência geral de náusea e vômito no pós-operatório (0−24 horas de pós-operatório) foi de 37,5% no grupo O e de 9,4% no grupo P (p = 0,016). A combinação palonosetrona-dexametasona associou-se com redução do risco absoluto de 28%, redução do risco relativo de 75%, e o número necessário para tratar foi 4. O escore de satisfação do paciente foi maior no grupo P (p = 0,016). A frequência da medicação de resgate foi mais comum no grupo O (p = 0,026). Conclusão: A combinação de palonosetrona-dexametasona é superior à ondansetrona-dexametasona na prevenção da náusea e vômito no pós-operatório após cirurgia de ouvido médio.

Abstract Background: Postoperative nausea and vomiting is the second most common complaint in the postoperative period after pain. The incidence of postoperative nausea and vomiting was 60-80% in middle ear surgeries in the absence of antiemetic prophylaxis. Because of this high incidence of postoperative nausea and vomiting, we aimed to assess the effect of palonosetron-dexamethasone and ondansetron-dexamethasone combination for the prevention of postoperative nausea and vomiting in patients of middle ear surgery. Methods: Sixty-four patients, scheduled for middle ear surgery, were randomized into two groups to receive the palonosetron-dexamethasone and ondansetron-dexamethasone combination intravenously before induction of anesthesia. Anesthesia technique was standardized in all patients. Postoperatively, the incidences and severity of nausea and vomiting, the requirement of rescue antiemetic, side effects and patient satisfaction score were recorded. Results: Demographics were similar in the study groups. The incidence difference of nausea was statistically significant between groups O and P at a time interval of 2-6 hours only (p = 0.026). The incidence and severity of vomiting were not statistically significant between groups O and P during the whole study period. The overall incidence of postoperative nausea and vomiting (0-24 hours postoperatively) was 37.5% in group O and 9.4% in group P (p = 0.016). Absolute risk reduction with palonosetron-dexamethasone was 28%, the relative risk reduction was 75%, and the number-needed-to-treat was 4. The patient’s satisfaction score was higher in group P than group O (p = 0.016). The frequency of rescue medication was more common in group O than in group P patients (p = 0.026). Conclusion: The combination of palonosetron-dexamethasone is superior to ondansetron-dexamethasone for the prevention of postoperative nausea and vomiting after middle ear surgeries.

Abstract In the fields of mathematical chemistry and chemical graph theory, a topological index generally called a connectivity index is a kind of a molecular descriptor that is calculated in perspective of the molecular graph of a chemical compound. Topological indices are numerical parameters of a graph which depict its topology and are graph invariant up to graph isomorphism. Topological indices are used for example in the progression of quantitative structure-activity relationships (QSARs) in which the common activity or distinctive properties of atoms are connected with their molecular structure. There are in excess of 140 topological indices but none of them totally describe the molecular compound completely so there is dependably a space to characterize and register new topological indices. Benzenoid Systems are utilized basically as an intermediate to make different synthetic compounds. In this report we aim to compute redefined Zagreb indices for Zigzag, Rhombic, triangular, Hourglass and Jagged-rectangle Benzenoid systems.

ABSTRACT The purpose of this study was to evaluate the effect of fat sources and emulsifier supplementation in different phases on growth performance of broilers. Treatments were; (T1) basal ration (BR) which contained soy oil (SO) and had inclusion of emulsifier for whole life, (T2) BR which contained poultry fat (PO) and had inclusion of emulsifier for whole life, (T3) BR which contained oxidized oil (OO) and had inclusion of emulsifier for whole life, (T4) BR which contained SO and had inclusion of emulsifier during starter phase (T5) BR which contained PO and had inclusion of emulsifier during the starter phase, (T6) BR which contained OO and had inclusion of emulsifier during the starter phase, (T7) BR which contained SO and had inclusion of emulsifier during the starter phase (T8) BR which contained PO and had inclusion of emulsifier during the grower phase, (T9) BR which contained OO and had inclusion of emulsifier during the grower phase, (T10) BR which contained SO and had inclusion of emulsifier during the finisher phase, (T11) BR which contained PO and had inclusion of emulsifier during the finisher phase (T12) BR which contained OO and had inclusion of emulsifier during the finisher phase. The Basal ration which contained SO and supplemented emulsifier during the grower phase and throughout life increased the body weight gain. The supplementation of emulsifier in the finisher phase and throughout life in a diet which contained SO had better feed conversion ratio. The supplementation of emulsifier in the finisher phase and throughout life in SO based diet increased the dry matter and crude fat digestibility. We recommend emulsifier supplementation in the finisher phase for the economic point of view.

ABSTRACT The objective of the current study was to check the effect of fat types and polyglycerol polyricinoleate (PGPR) levels in broiler diets on broilers performance. For this purpose, three sources of fat {soy oil (SO), poultry oil (PO), and oxidized oil (OO) (oxidized soy oil)} and four levels of PGPR were used in a 3×4 factorial arrangement. The trial had 12 different dietary treatments: (T1) basal ration (BR) containing SO without PGPR supplementation, (T2) BR containing PO without PGPR supplementation, (T3) BR containing OO without PGPR supplementation, (T4) BR containing SO with PGPR supplementation (0.025%), (T5) BR containing PO with PGPR supplementation (0.025%), (T6) BR containing OO with PGPR supplementation (0.025%), (T7) BR containing SO with PGPR supplementation (0.035%), (T8) BR containing PO with PGPR supplementation (0.035%), (T9) BR containing OO with PGPR supplementation (0.035%), (T10) BR containing SO with PGPR supplementation (0.045%), (T11) BR containing PO with PGPR supplementation (0.045%), (T12) BR containing OO with PGPR supplementation (0.045%). Results revealed that interaction was present for fat sources and PGPR levels in the current experiment (p<0.05) for feed conversion ratio, body weight, dry matter (DM) and crude fat (CF) digestiblities (p<0.05). In overall trial, interaction results of PGPR and fat sources showed that performance of birds and nutrient digestiblities of DM and CF was increased in birds received diet contained SO and PGPR @ 0.35%. It is concluded that PGPR @ 0.035% could be successfully used in broiler ration contained soy oil to improve the performance.

ABSTRACT The current study was planned to investigate the influence of soy oil, oxidized soy oil, poultry oil single refined and poultry oil double refined on the performance of broilers chicken. A total of two hundred and forty, day-old broiler chicks were divided into 4 treatments in such a way that each treatment had six replicates and each replicate had ten chicks. The experimental treatments were separated with the usage of single refined poultry oil, double refined poultry oil, oxidized soy oil and soy oil in the diet of broilers. In both starter and overall periods average body weight was higher (p<0.05) for birds which were on a basal diet containing soy oil as compared to other diets. Similarly, feed intake was higher (p<0.05) for birds which were on a basal diet containing soy oil in the starter phase. In the overall phase, average body weight was less in oxidized oil as compared to other dietary treatments (p<0.05). Similarly, birds showed poor feed conversion ratio in the basal diet that contained oxidized oil (p<0.05) in the overall phase of the experiment. The birds showed better digestibility (p<0.05) for crude fat on a basal diet containing vegetable oil and double refined poultry oil as compared to other diets. Results showed no effects of experimental treatments on the meat quality and carcass parameters (p>0.05). Therefore, it can be concluded that poultry single refined and double refined oil could be a possible substitute for fresh soy oil for better performance as compared to oxidized soy oil.

Resumen Introducción: El uso de aleloquímicos como sustitutos baratos y amigables con el ambiente para el manejo de hierbas en plantaciones es un tema central actualmente. Objetivo: En el presente estudio se midió la actividad alelopática de 73 hierbas en Pakistán a través de los métodos “sandwich” y “dish pack”, con el fin de investigar los compuestos aleloquímicos más importantes en las hierbas analizadas. Métodos: A través del método “sandwich” se determinaron los efectos alelopáticos de los lixiviados de hojas en las hierbas analizadas, mientras que el efecto alelopático volátil a través de la técnica “dish pack”. Para investigar el potencial aleloquímico de Melilotus indicus se aplicaron técnicas fitoquímicas tanto cualitativas como cuantitativas. El análisis estadístico de los datos describió el efecto alelopático de 73 especies de hierbas sobre el crecimiento radicular y del hipocótilo en plántulas de lechuga. Resultados: El porcentaje de elongación radicular y del hipocotilo varió entre 0-74 % hasta 0-148 % y 0-75 % hasta 0-84 % respectivamente, con una concentración de 10 mg de polvo de planta seca con el método “sandwich”. Además, fue entre 2-234 % y 7-150 % con el método “dish pack”. Entre las plantas analizadas para actividad fitotóxica, M. indicus presentó los aleloquímicos más fuertes. Los análisis cualitativos y cuantitativos de M. indicus mostraron la presencia de flavonoides y compuestos fenólicos, junto con otros aleloquímicos. Conclusiones: Las hierbas seleccionadas pueden tener un potencial aleloquímico fuerte que ayude al desarrollo de compuestos bioactivos de plantas, para usar como hierbicidas y pesticidas naturales en el manejo sostenible de plagas y malas hierbas.

Abstract Introduction: Use of allelochemicals as inexpensive, biodegradable and eco-friendly substitutes for the management of weeds in crops is a central topic nowadays. Objective: The current study represented the comprehensive screening of allelopathic activity of 73 weeds in Pakistan by the Sandwich method and dish pack method. To investigate the allelochemical compound in top most allelopathic weed. Methods: Allelopathic effects of selected weeds leaves leachate were determined through sandwich technique, while volatile allelopathic effects through dish pack techniques. Qualitative and quantitative phytochemical techniques were applied to investigate allelochemical potential of Melilotus indicus. The statistical analysis of the data described the allelopathic effect of 73 weed plants on lettuce seedling growth in terms of radicle and hypocotyl elongation. Results: Elongation percentage of radicle and hypocotyl ranged 0-74 % to 0-148 % and 0-75 % to 0-84 % respectively at 10 mg concentration of dry plant powder in sandwich method while it was 2-234 % and 7-150 % at in Dish Pack method. Among the plants screened for phytotoxic activity, M. indicus contained the strongest allelochemicals. Qualitative and quantitative analysis of M. indicus showed the presence of flavonoids and phenolic compound along with other allelochemical. Conclusions: Selected weeds may have strong allelochemical potential that can help in the development of bioactive compounds from plant species to be used as natural herbicides and pesticides for sustainable management of weeds and pest.

RESUMO A grande maioria das pesquisas caracteriza a política organizacional como um fenômeno aversivo, portanto recomenda que sejam explorados os fatores para minimizar a sua intensidade. Este estudo objetivou principalmente examinar o papel das práticas do Sistema de Trabalho de Alto Desempenho (STAD) no controle da política organizacional. A influência moderadora das personalidades maquiavé licas também foi avaliada nos STAD em relação à percepção de política organizacional (PPO). Por meio de questionário, foram obtidas 243 respostas de engenheiros que trabalham na área industrial local. Os resultados mostraram uma relação inversa entre STAD e PPO. Da mesma forma, o papel moderador do maquiavelismo foi confirmado. A discussão e as implicações práticas são apresentadas com base nos resultados do estudo.

ABSTRACT A vast majority of research characterizes organizational politics as an aversive phenomenon and thus recommends exploring the factors that minimize its intensity. This study primarily endeavored to examine the role of high performance work practices (HPWPs) in controlling organizational politics. The moderating influence of Machiavellian personalities on HPWPs- politics was also evaluated. Through a questionnaire survey, 243 responses were obtained from engineers working in a local industrial area of capital city of Pakistan. The results showed an inverse relationship between HPWPs and perceived organizational politics (POP), and the moderating role of Machiavellianism was substantiated. Practical implications are presented based on the study results.

RESUMEN Una vasta mayoría de investigaciones caracteriza a las políticas organizacionales como un fenómeno aversivo, por consiguiente, recomendado para explorar los factores para minimizar la intensidad. Este estudio intenta primariamente analizar el papel de las prácticas laborales de alto rendimiento (high performance work practices [HPWPs]) en controlar las políticas organizacionales. La influencia moderadora de personalidades maquiavélicas también se evaluó en HPWPs para la relación de políticas percibidas. A través de una encuesta con cuestionario, se obtuvieron 243 respuestas de ingenieros que trabajan en el área industrial local. Los resultados presentados mostraron una relación inversa entre HPWPs y la percepción de la política organizacional. Asimismo se corroboró el papel moderador del maquiavelismo. El debate y las implicaciones prácticas se presentan con base en los resultados del estudio.