ABSTRACT This work highlights the relationship between accountability and systems assessment, based on research on assessment policies for basic education in Brazil and Uruguay. Systems assessment has been gathering prominence within the historical-political scenario and it also shows a different unfolding in each country. This qualitative research was conducted upon the analysis of two cases (Brazil and Uruguay), document/bibliographic surveys and content analysis as well. It is inferred, consequently, that these assessments may point out to limitations towards social quality education.

RESUMO Este artigo destaca as relações entre accountability e a avaliação de sistema, a partir das análises das avaliações da educação obrigatória do Brasil e do Uruguai. As avaliações de sistema ganham destaque no contexto histórico-político e se desdobram diferentemente em cada país. A pesquisa qualitativa foi desenvolvida a partir do estudo de dois casos (Brasil e Uruguai), por meio de levantamento documental e bibliográfico, e, análise de conteúdo. Entende-se que estas avaliações podem apontar para limitações no que tange à educação de qualidade social.

Abstract Due to the great interest in ovarian cryopreservation and, consequently conservation and restoration of female fertility in the last decades, different vitrification procedures (vitrification devices or solutions) have been developed, patented, and used both for academic research purposes and for clinical use. Therefore, the present study aimed to provide a systematic review and meta-analysis of data obtained from the application of different patented and non-patented vitrification devices and solutions in different countries. For this purpose, relevant observational studies published between the years 2000 to 2021 were selected to verify the efficiency of ovarian vitrification processes on parameters such as morphology, viability, and apoptosis in preantral ovarian follicles after transplantation or in vitro culture. Our research revealed that, although several countries were considered in the study, the United States and Japan were the countries that registered the most processes, and 22 and 16 vitrification devices and solutions out of a total of 51, respectively were patented. Sixty-two non-patented processes were also considered in the study in all countries. We also observed that transplantation and in vitro ovarian culture were the techniques predominantly used to evaluate the efficiency of the devices and vitrification solutions, respectively. In conclusion, this review showed that patented or non-patented protocols available in the literature are able to successfully preserve preantral follicles present in ovarian tissue. Despite the satisfactory results reported so far, adjustments in ovarian vitrification protocols in order to minimize cryoinjuries to the follicles remain one of the goals of cryopreservation and preservation of the female reproductive function. We found that vitrification alters the morphology and viability, and offers risks leading in some cases to follicular apoptosis. However, adjustments to current protocols to develop an optimal procedure can minimize damage by not compromising follicular development after vitrification/warming.

Abstract Introduction The concept of quality of life is multidimensional, presents a complex and dynamic organization of its components, and differs from person to person according to the environment/context and even between two people in a similar context. In December 2019, a Coronavirus epidemic emerged in China, aiming to make some changes, including social isolation and distance learning. Objective Evaluate the impact of social isolation and distance learning on the quality of life of undergraduates in the health area at the Federal University of Sergipe. Material and method The quality of life questionnaire, Short-Form Health Survey, was applied to undergraduate students in the health area at the Federal University of Sergipe in January 2021. The questionnaire was applied online. Result 678 questionnaires were applied, with 672 agreeing to participate in the study. According to the evaluated students, 58% were female and 50% were aged from 21 to 25 years. When analyzing the questionnaire, it appears that the values ranged from 80 to 89 for functional capacity, with a good quality of life score. Emotional aspects had the lowest scores from 21 to 37.3, the worst result in speech therapy students. There was no statistically significant difference between the different health courses studied. Conclusion It appears that the emotional aspect has been the most affected among health students at the Federal University of Sergipe.

Resumo Introdução O conceito de qualidade de vida é multidimensional, apresenta uma organização complexa e dinâmica dos seus componentes, difere de pessoa para pessoa de acordo com seu ambiente/contexto e mesmo entre duas pessoas inseridas em um contexto similar. Em dezembro de 2019 surgiu na China uma epidemia pelo coronavírus, surgindo a necessidade de mudanças, incluindo isolamento social e ensino a distância. Objetivo Avaliar o impacto do isolamento social e ensino a distância na qualidade de vida dos graduandos da área da saúde da Universidade Federal de Sergipe. Material e método Foi aplicado aos estudantes de graduação da área de saúde da Universidade Federal de Sergipe, no período de janeiro de 2021, o questionário de qualidade de vida, Short-Form Health Survey. O questionário foi aplicado via o sistema online. Resultado Foram aplicados 678 questionários, sendo 672 concordando em participar do estudo. Dos estudantes avaliados, 58% eram do sexo feminino e 50% com idade de 21 a 25 anos. Ao se analisar o questionário, verifica-se que para capacidade funcional os valores variaram de 80 a 89, ou seja, com bom escore de qualidade de vida. Os aspectos emocionais apresentaram os menores escores e 21 a 37,3, sendo o pior resultado encontrado nos estudantes do curso de fonoaudiologia. Não houve diferença estatisticamente significativa entre os diferentes cursos de saúde estudados. Conclusão Verifica-se que o aspecto emocional tem sido o mais afetado entre os estudantes de saúde da Universidade Federal de Sergipe.

RESUMO O desenvolvimento do sistema nervoso humano compõe uma série de eventos fundamentais e interdependentes envolvendo o nascimento, crescimento e maturação neuronal, além da seleção positiva ou negativa de sinapses desses neurônios que participarão da composição de circuitos neurais essenciais à atividade do sistema nervoso. Nesse contexto, em que o ambiente e as relações sociais parecem ser marcadores relevantes para o neurodesenvolvimento, técnicas avançadas de neuroimagem e ferramentas de avaliação comportamental têm demonstrado alterações em regiões cerebrais e funções cognitivas em crianças que se desenvolvem em ambientes de baixo ou alto nível socioeconômico. Considerando os aspectos mencionados, esta revisão teve como objetivo identificar a importância do status socioeconômico no desenvolvimento cerebral infantil, buscando identificar quais são os impactos desses fatores na formação morfológica e fisiológica do sistema nervoso, permitindo maior compreensão da importância dos fatores ambientais nos processos de neurodesenvolvimento. nascimento neuronal contexto neurodesenvolvimento mencionados infantil

ABSTRACT The development of the human nervous system makes up a series of fundamental and interdependent events involving birth, growth, and neuronal maturation, in addition to the positive or negative selection of synapses of these neurons that will participate in the composition of neural circuits essential to the activity of the nervous system. In this context, where environment and social relationships seem to be relevant markers for neurodevelopment, advanced neuroimaging techniques and behavioral assessment tools have demonstrated alterations in brain regions and cognitive functions among children developing in low or high socioeconomic status environments. Considering the aspects mentioned, this review aimed to identify the importance of socioeconomic status in children’s brain development, seeking to identify what are the impacts of these factors on the morphological and physiological formation of the nervous system, allowing a greater understanding of the importance of environmental factors in neurodevelopmental processes. birth growth maturation context neurodevelopment environments mentioned childrens s processes

Abstract Public scientific communication in universities aims to encourage dialogue between scientists and society. By involving citizens in debates about its teaching, research, and extension actions, the university facilitates the exchange of knowledge with the community. In this paper, we discuss how this relationship is established through the project Pergunte aos Cientistas (Ask the Scientists), in which the population could clarify doubts about COVID-19 with researchers from different fields of knowledge. We, the authors of this article, are part of the Agência Escola (School Agency), an initiative for public communication and scientific dissemination of the Federal University of Paraná, the oldest educational institution in Brazil. Through descriptive analysis, we identify the public participating in this project and reflect on the relationships between society and scientists. To do so, we employ the concepts of open science (Recomendação da UNESCO Sobre Ciência Aberta, 2021), scientific dissemination (Caldas, 2010; Granado & Malheiro, 2015), and public communication of science (Bucchi, 2008; Manso, 2015). The studies on public formation (Dewey, 1946; Henriques, 2018) were essential to understanding how the participation of the publics in Pergunte aos Cientistas develops. The initiative has demonstrated the importance of citizens being active and aware of their surroundings. The exchange between scientists and society is beneficial for both parties: the former can map the population’s doubts and needs, enabling the development of research based on social demands, while the latter discovers that it also has a space to show and expand its knowledge along with an academic community that has its doors open to society.

Resumo A comunicação pública da ciência na universidade tem o propósito de incentivar o diálogo entre a sociedade e seus cientistas. Ao envolver o cidadão nos debates sobre suas ações de ensino, pesquisa e extensão, a universidade possibilita a troca de conhecimentos com a comunidade. Aqui discutimos como essa relação é estabelecida por meio do projeto Pergunte aos Cientistas, no qual a população pôde esclarecer dúvidas sobre a COVID-19 com pesquisadores de diferentes áreas do conhecimento. Nós, autoras deste artigo, fazemos parte da Agência Escola de Comunicação Pública e Divulgação Científica da Universidade Federal do Paraná, que se apresenta como a instituição de ensino mais antiga do Brasil. Por meio da análise descritiva, identificamos os públicos que participaram nessa ação e refletimos sobre a aproximação entre a so ciedade e os cientistas. Para tanto, acionamos os conceitos de ciência aberta (Recomendação da UNESCO Sobre Ciência Aberta, 2021), divulgação científica (Caldas, 2010; Granado & Malheiro, 2015) e comunicação pública da ciência (Bucchi, 2008; Manso, 2015). Os estudos de formação de públicos (Dewey, 1946; Henriques, 2018) foram fundamentais para compreender como se dá a participação dos públicos no Pergunte aos Cientistas. A iniciativa tem demonstrado a importância de um cidadão ativo e ciente do seu entorno. Nesta troca de comunicação entre cientistas e a sociedade, ambos são beneficiados. Os cientistas conseguem mapear dúvidas e necessidades da população, possibilitando o desenvolvimento de pesquisas a partir das demandas sociais. Por sua vez, a sociedade descobre que também tem espaço para mostrar os seus saberes e adquirir mais conhecimento com uma universidade que abre as portas para a sua comunidade.

Abstract Objective: To assess the level of satisfaction and quality of life (QOL) of caregivers of Patients with Special Needs seen at the Dental Specialties Center in Aracaju, Brazil. Material and Methods: The Program for Primary Care Access and Quality Improvement (PMAQ – DSC) and the World Health Organization's Quality of Life - Brief (WHOQOL-BREF) questionnaires were applied to PSN and caregivers. Results: The PMAQ questionnaire was applied to 31 patients or caregivers; 97% had no paid work and 61% used public transportation to reach the Dental Specialties Center. The WHOQOL-BREF questionnaire was applied to 20 caregivers; 60% considered their life to be good; however, 60% had practically no leisure time. Correlation tests (Pearson’s coefficient) showed a statistically significant correlation between the physical and psychological domain (p=0.02; r=0.64), the psychological and social domain (p=0.033; r=0.48), and the psychological and environment domain (p<0.001; r=0.80). Conclusion: The caregivers and patients with special needs felt satisfied with the specialized oral health service offered by the municipality. Concerning the quality of life of caregivers, the majority stated they had a good quality of life, despite not having the opportunity to participate in leisure-oriented activities and often having negative feelings.

RESUMO O objetivo deste estudo foi relatar a experiência dos alunos do mestrado profissional em gestão de serviços de saúde acerca da utilização de conceitos da Análise Institucional, para analisar as resistências ao trabalho interprofissional e interdisciplinar na saúde, localizando-as como um analisador do processo e das relações de trabalho. O estudo foi elaborado a partir da vivência e da análise dos diários institucionais, escritos pelos alunos e analisados com base no referencial teórico da Análise Institucional. Observou-se que a resistência ao trabalho interprofissional e interdisciplinar, principalmente por parte dos médicos, atravessa as organizações de saúde, as relações de trabalho e a assistência aos usuários. Entretanto, essa resistência também é exercida por outros profissionais e pelos usuários, o que limita a interdisciplinaridade e a integralidade da assistência à saúde. Todavia, se, por um lado, ainda, há certa predominância do modelo biomédico, por outro, também se observam resistências a esse modelo nas organizações de saúde, necessitando ampliar os espaços de análise coletiva capazes de enunciar o reducionismo desse paradigma. Conclui-se que analisar coletivamente essas resistências possibilita aos profissionais da saúde ampliar as condições de sair de seus lugares instituídos e perceber os movimentos instituintes nos serviços em que atuam.

ABSTRACT This study aimed to report the experience of the students of the professional master’s degree in health services management, regarding the use of concepts of Institutional Analysis, to analyze the resistances to interprofessional and interdisciplinary work in health, locating them as an analyzer of the process and of work relationships. The study was prepared from the experience and analysis of institutional journals, written by students, and analyzed based on the theoretical framework of Institutional Analysis. It was observed that resistance to interprofessional and interdisciplinary work, especially on the part of physicians, crosses health organizations, work relationships, and assistance to users. However, this resistance is also exercised by other professionals and users, which limits the interdisciplinarity and comprehensiveness of health care. But if, on the one hand, there is still a certain predominance of the biomedical model, on the other hand, resistance to this model is also observed in health organizations, needing to expand the spaces of collective analysis capable of enunciating the reductionism of this paradigm. It can be concluded that collectively analyzing these resistances allows health professionals to expand the conditions to leave their established places and perceive the instituting movements in the services in which they work.

RESUMO Objetivo Analisar a autopercepção de esforço vocal, sinais e sintomas vocais e fadiga vocal em professores antes e durante a pandemia da COVID-19; e os fatores relacionados a dados sociodemograficos e ocupacionais que pudessem prever a autopercepção durante a pandemia. Métodos Participaram do estudo 263 professores brasileiros que estavam trabalhando em home office durante a pandemia. Eles responderam um questionário sobre dados sociodemográficos e ocupacionais, escala de Borg CR10-BR adaptada para classificação de esforço vocal, Lista de Sinais e Sintomas Vocais e Índice de Fadiga Vocal. Os questionários de autoavaliação vocal foram respondidos duas vezes, considerando antes e durante a pandemia. Resultados A autopercepção de esforço vocal, sinais e sintomas vocais e fadiga vocal durante a pandemia em professores foi menor do que antes da pandemia. Na comparação dos desfechos por queixa vocal, os professores sem queixa vocal apresentaram valores menores do que aqueles com queixa vocal. Professores com queixas vocais durante a pandemia apresentaram maior autopercepção de fadiga vocal. Professores de educação infantil, ensino fundamental e ensino médio relataram mais sinais e sintomas vocais antes do que durante a pandemia. Conclusão Em geral, os professores relatam diminuição do esforço vocal e dos sinais e sintomas vocais durante a pandemia de COVID-19. Professores com queixas vocais apresentam maior percepção de esforço vocal, sinais e sintomas vocais e fadiga vocal. A presença de queixas vocais e as variáveis relacionadas à demanda vocal durante a pandemia estão relacionadas à percepção de esforço vocal, sinais e sintomas vocais e fadiga vocal.

ABSTRACT Purpose This study aims to analyze the self-perception of vocal effort, vocal signs and symptoms, and vocal fatigue in teachers before and during the COVID-19 pandemic; and factors related to sociodemographic and occupational data that could predict self-perception during the pandemic Methods Participants were 263 Brazilian teachers working from in-home office during the pandemic. They answered a questionnaire on sociodemographic and occupational data, adapted Borg CR10-BR for vocal effort ratings, Vocal Signs and Symptoms List, and Vocal Fatigue Index. The vocal self-assessment questionnaires were answered twice, considering the period before and during the pandemic. Results The self-perception of vocal effort, vocal signs and symptoms, and vocal fatigue during the pandemic in teachers was lower than before the pandemic. In comparing outcomes due to vocal complaints, teachers with no vocal complaints presented lower values than those with vocal complaints. Teachers with vocal complaints during the pandemic showed greater self-perception of vocal fatigue. Teachers at early education, elementary, and high schools self-reported more vocal signs and symptoms before than during the pandemic. Conclusion In general, teachers report decreased vocal effort and vocal signs and symptoms during the COVID-19 pandemic. Teachers with vocal complaints have a higher perception of vocal effort, vocal signs and symptoms, and vocal fatigue. The presence of vocal complaints and the variables related to vocal demand during the pandemic are related to the perception of vocal effort, vocal signs and symptoms, and vocal fatigue.

RESUMO O objetivo deste estudo foi relatar a experiência dos alunos do mestrado profissional em gestão de serviços de saúde acerca da utilização de conceitos da Análise Institucional, para analisar as resistências ao trabalho interprofissional e interdisciplinar na saúde, localizando-as como um analisador do processo e das relações de trabalho. O estudo foi elaborado a partir da vivência e da análise dos diários institucionais, escritos pelos alunos e analisados com base no referencial teórico da Análise Institucional. Observou-se que a resistência ao trabalho interprofissional e interdisciplinar, principalmente por parte dos médicos, atravessa as organizações de saúde, as relações de trabalho e a assistência aos usuários. Entretanto, essa resistência também é exercida por outros profissionais e pelos usuários, o que limita a interdisciplinaridade e a integralidade da assistência à saúde. Todavia, se, por um lado, ainda, há certa predominância do modelo biomédico, por outro, também se observam resistências a esse modelo nas organizações de saúde, necessitando ampliar os espaços de análise coletiva capazes de enunciar o reducionismo desse paradigma. Conclui-se que analisar coletivamente essas resistências possibilita aos profissionais da saúde ampliar as condições de sair de seus lugares instituídos e perceber os movimentos instituintes nos serviços em que atuam. Institucional localizandoas localizando institucionais Observouse Observou médicos usuários Entretanto Todavia lado ainda biomédico outro paradigma Concluise Conclui atuam

ABSTRACT This study aimed to report the experience of the students of the professional master’s degree in health services management, regarding the use of concepts of Institutional Analysis, to analyze the resistances to interprofessional and interdisciplinary work in health, locating them as an analyzer of the process and of work relationships. The study was prepared from the experience and analysis of institutional journals, written by students, and analyzed based on the theoretical framework of Institutional Analysis. It was observed that resistance to interprofessional and interdisciplinary work, especially on the part of physicians, crosses health organizations, work relationships, and assistance to users. However, this resistance is also exercised by other professionals and users, which limits the interdisciplinarity and comprehensiveness of health care. But if, on the one hand, there is still a certain predominance of the biomedical model, on the other hand, resistance to this model is also observed in health organizations, needing to expand the spaces of collective analysis capable of enunciating the reductionism of this paradigm. It can be concluded that collectively analyzing these resistances allows health professionals to expand the conditions to leave their established places and perceive the instituting movements in the services in which they work. masters master s management Analysis relationships journals physicians organizations users However care if hand paradigm

Resumo O objetivo deste trabalho foi avaliar a substituição parcial da goma arábica por amidos modificados, na microencapsulação do óleo essencial de capim-limão (Cymbopogon flexuosus), por meio de secagem por atomização. As emulsões assistidas por ultrassom foram preparadas com 30% (m/m) de material de parede, 7,5% (m/m) de carga de óleo e 1:1 (m/m) de taxa de substituição para todos os tratamentos. Após 16 horas, a incompatibilidade observada entre a goma arábica e o anidrido octenil succínico (AOS) não afetou as micropartículas obtidas, uma vez que o tratamento com o amido AOS, em substituição parcial à goma arábica, apresentou os melhores resultados quanto ao rendimento do processo e à retenção de carga de óleo após a secagem por atomização, e o tratamento mostrou viscosidade newtoniana próxima à do tratamento preparado com goma arábica. A maltodextrina dextrose equivalente 10 (10DE) mostra uma carga de óleo semelhante à do tratamento com goma arábica, enquanto a presença de maltodextrina de milho DE20 reduz o teor de óleo encapsulado e a eficiência do processo de secagem, em razão da aderência das partículas à câmara. Portanto, a substituição parcial da goma arábica mostra-se como alternativa para a formação de emulsões, para a microencapsulação por meio de secagem por atomização do óleo essencial de capim-limão.

Abstract The objective of this work was to evaluate the partial replacement of gum arabic by modified starches on the spray-drying microencapsulation of lemongrass (Cymbopogon flexuosus) essential oil. The ultrasound-assisted emulsions were prepared with 30% (w/w) of wall material, 7.5% (w/w) of oil load, and 1:1 (w/w) replacement ratio for all treatments. After 16 hours, the incompatibility observed between gum arabic and octenyl succinic anhydride (OSA) starch did not affect the obtained microparticles, since the treatment with OSA starch, partially replacing gum arabic, showed the best results for the process yield and for the oil charge retention after spray-drying process, and the treatment showed Newtonian viscosity close to that of the treatment prepared with gum arabic. Maltodextrin dextrose equivalent 10 (10DE) shows an oil load similar to that of the treatment with gum arabic, while the presence of maize maltodextrin DE20 reduces the content of encapsulated oil and the efficiency of the drying process due to the adherence of particles to the chamber. Therefore, the partial substitution of gum arabic is an alternative for the formation of emulsions, for the spray-drying microencapsulation of lemongrass essential oil.

Resumo O objetivo deste artigo é relatar o caso clínico de um menino de 3 anos e 7 meses de idade com microcefalia com múltiplos cistos de erupção e discutir as condutas adotadas. Baseadas nos aspetos clínicos e radiográficos, o diagnóstico foi de cisto de erupção. Para o tratamento optou-se pela incisão cirúrgica dos cistos de erupção, sob anestesia geral, mas por motivos de saúde o paciente não pode realizar o procedimento proposto e, após 4 meses, sete dos oito cistos de erupção tinham desaparecidos com a irrupção dos molares decíduos, sem necessidade de intervenção cirúrgica. No que diz respeito ao cisto de erupção remanescente a terapêutica eleita foi o acompanhamento e descompressão manual realizada pela mãe. É possível individualizar o tratamento do cisto de erupção optando-se pelo acompanhamento da lesão com o desaparecimento espontâneo da mesma, sem qualquer tipo de intervenção.

Abstract The aim of this paper is to report the clinical case of a 3-year and 7-month-old male child with microcephaly who had multiple eruption cysts, and to discuss the adopted procedures. The diagnosis of eruption cyst was concluded based on the clinical and radiographic characteristics. The treatment proposed was a surgical incision of the eruption cysts with the patient under general anesthesia. However, due to health reasons, the patient could not have the procedure performed, and, after four months, seven of the eight eruption cysts had regressed with teeth eruption; therefore, no surgical intervention was needed. Regarding the remaining eruption cyst, the therapy adopted was his mother monitoring the condition. It is possible to personalize eruption cyst treatment by monitoring the lesion until its eventual spontaneous disappearance, without any type of intervention.

The membrane-based efflux pump systems are recognized to have an important role in pathogenicity and drug resistance in Mycobacterium tuberculosis by the extrusion of toxic substrates and drugs from the inner bacillus. This study aimed to investigate the in vitro interaction of Verapamil (VP), an efflux pump inhibitor, with the classical first-line anti-tuberculosis drug isoniazid (INH) in resistant and susceptible M. tuberculosis clinical isolates. Seven multidrug-resistant (MDR), three INH monoresistant and four susceptible M. tuberculosis clinical isolates were tested for the INH and VP combination by modified Resazurin Microtiter Assay Plate (REMA). Fractional Inhibitory Concentration (FIC) and Modulation Factor (MF) were determined. The INH plus VP combination showed no significant change in the Minimum inhibitory concentration (MIC) values of INH (FIC≥ 0.5; MF=1 or 2).The use of VP in tuberculosis therapy should be managed carefully, considering the resistance caused by specific mutation in katG and inhA genes, in which the use of these EPIs may have no success. The use of EPIs as an adjunctive drug in the anti-tuberculosis therapy should be further investigated on a larger number of M. tuberculosis clinical isolates with different resistant profile.

Abstract INTRODUCTION: We assessed the clinical-epidemiological profile of acquired immune deficiency syndrome (AIDS) patients in the Santos region (São Paulo state) with the highest AIDS prevalence in Brazil. METHODS Information was extracted from records of 409 AIDS-infected patients hospitalized between 2011 and 2016. RESULTS: Human immunodeficiency virus (HIV) was diagnosed in 24.7% of patients during admission, and 39.6% of already diagnosed patients received highly active antiretroviral therapy (HAART) irregularly. The mortality rate was 19.1%, and the main secondary manifestations were neurotoxoplasmosis and tuberculosis. CONCLUSIONS: AIDS patients in the Santos region had high rates of late diagnosis and low treatment adherence.

RESUMO Segundo a OMS, em 2025 o Brasil ficará em sexto lugar no ranking mundial em termos de proporção de idosos na população. Nesse âmbito, a cognição desempenha um papel central no processo de envelhecimento, tendo uma importante associação com a qualidade de vida, o que sugere a necessidade de desenvolver programas de intervenção, como o treinamento cognitivo. Objetivo: Determinar os efeitos de um programa de oficinas de estimulação cognitiva na autoestima e cognição de idosos. Métodos: Trinta e oito idosos completaram o protocolo de três etapas: 1) Levantamento de dados demográficos e avaliação da cognição por uma bateria neuropsicológica e de autoestima utilizando a Escala de Autoestima de Rosenberg (RSS), antes do treinamento; 2) Participação em doze oficinas de estimulação cognitiva; e 3) Avaliação cognitiva e RSS após o treinamento. Resultados: Os resultados mostraram que o uso de treinamento produziu efeitos positivos no desempenho do teste cognitivo de idosos com e sem comprometimento cognitivo. Por extensão, isso demonstra um impacto positivo em sua autoestima. Conclusão: Estes resultados encorajam o investimento em programas de estimulação cognitiva como um recurso para melhorar a cognição e a qualidade de vida dos idosos. Queixa cognitiva subjetiva pode ter servido como um preditor de diminuição da autoestima; portanto, como o treinamento melhorou a cognição, também melhorou a autoestima.

ABSTRACT According to the WHO, by 2025 Brazil will be ranked sixth in the world in terms of proportion of elderly in the population. Within this scope, cognition plays a central role in the aging process, having an important association with quality of life, which suggests the need to develop intervention programs, such as cognitive training. Objective: To determine the effects of a program of cognitive stimulation workshops on the self-esteem and cognition of elderly people. Methods: Thirty-eight elderly subjects completed the three-step protocol: 1) Survey of demographic data and evaluation of cognition by a neuropsychological battery and of self-esteem using the Rosenberg Self-Esteem Scale (RSS), prior to training; 2) Participation in twelve cognitive stimulation workshops; and 3) Cognitive evaluation and RSS after the training. Results: Results showed that the use of training produced positive effects on cognitive test performance of the elderly with and without cognitive impairment. By extension, this demonstrates positive impact on their self-esteem. Conclusion: These findings encourage investment in cognitive stimulation programs as a resource for improved cognition and quality of life for the elderly. Subjective cognitive complaint may have served as a predictor of decreased self-esteem; therefore, as training improved cognition, it also improved self-esteem.

Abstract Purpose: To evaluate in vivo animal model of cardiac ischemia/reperfusion the cardioprotective activity of pancreatic lipase inhibitor of the orlistat. Methods: Adult male Wistar rats were anesthetized, placed on mechanical ventilation and underwent surgery to induce cardiac I/R by obstructing left descending coronary artery followed by reperfusion to evaluation of ventricular arrhythmias (VA), atrioventricular block (AVB) and lethality (LET) with pancreatic lipase inhibitor orlistat (ORL). At the end of reperfusion, blood samples were collected for determination of triglycerides (TG), very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), high-density lipoprotein (HDL), lactate dehydrogenase (LDH), creatine kinase (CK), and creatine kinase-MB (CK-MB). Results: Treatment with ORL has been able to decrease the incidence of VA, AVB and LET. Besides that, treatment with ORL reduced serum concentrations of CK and LDL, but did not alter the levels of serum concentration of TG, VLDL and HDL. Conclusion: The reduction of ventricular arrhythmias, atrioventricular block, and lethality and serum levels of creatine kinase produced by treatment with orlistat in animal model of cardiac isquemia/reperfusion injury suggest that ORL could be used as an efficient cardioprotective therapeutic strategy to attenuate myocardial damage related to acute myocardial infarction.