RESUMO Objective Determinar a aceitabilidade e os fatores associados à realização do exame físico para detecção de infecções sexualmente transmissíveis (IST) sintomáticas em mulheres trans e travestis no Brasil. Métodos: Foram utilizados dados do “TransOdara”, estudo transversal de prevalência de IST, realizado em cinco capitais brasileiras (Campo Grande, Manaus, Porto Alegre, Salvador e São Paulo) entre dezembro de 2019 e julho de 2021. As 1.317 mulheres trans e travestis, com idade ≥18 anos, recrutadas por meio do método respondent-driven sampling passaram por entrevistas e responderam a um questionário estruturado. Foi ofertada consulta médica, incluindo realização de exame físico e coleta de amostras de vários locais para detectar diversas IST. Para a análise dos fatores associados à aceitabilidade do exame físico (geral, genital e anorretal), considerou-se as características sociodemográficas das participantes que permitiram a sua realização. Resultados: A maioria (65,4%; intervalo de confiança – IC95% 62,7–68,0) concedeu permissão para o exame geral (incluindo orofaríngeo), com permissão concedida em menor proporção para os exames genitais (42,3%; IC95% 39,6–46,0) ou anorretais (42,1%; IC95% 39,4–44,9). No geral, 34,4% (IC95% 31,8–37,0) delas recusaram todos os exames. As participantes com sintomas de IST foram significativamente mais propensas a conceder permissão para o exame completo do que as participantes assintomáticas (64,3 vs 37,4%, odds ratio ajustado – AOR=3,6, IC95% 2,4–5,5). Os fatores significativamente associados à aceitabilidade do exame completo na análise multivariada incluíram idade (AOR=1,5 para ≥25 anos), religião (AOR=2,0 para afro-brasileiras, AOR=1,9 para outras religiões em comparação com nenhuma religião) e nível de escolaridade (AOR=2,0 para nível superior). Conclusão: No contexto do manejo de IST, nós observamos aceitação limitada de exames anogenitais entre mulheres trans e travestis, com maior aceitação entre aquelas com sintomas de IST.

ABSTRACT Objective This study aimed to determine the acceptability and factors associated with uptake of a physical examination for the detection of symptomatic sexually transmitted infections (STIs) by transgender women and travestis in Brazil. Methods: TransOdara was a multi-centric, cross-sectional STI prevalence study conducted among transgender women and travestis in five capital cities (Campo Grande, Manaus, Porto Alegre, Salvador and São Paulo) representing all Brazilian regions, between December 2019 and July 2021. A total of 1,317 self-identified transgender women and travestis aged ≥18 years were recruited using respondent-driven sampling and responded to a standard questionnaire. A medical consultation was offered including a physical examination and collection of samples from multiple sites to detect various STIs. Factors associated with uptake were investigated by reviewing demographic characteristics of participants who gave permission for physical examination (general, genital, and anorectal). Results: Most participants (65.4%, 95% confidence interval — 95%CI 62.7–68.0) gave permission for a general examination (including oropharyngeal), with fewer permitting genital (42.3%, 95%CI 39.6–46.0) or anorectal (42.1%, 95%CI 39.4–44.9) examinations. Overall, 34.4% (95%CI 31.8–37.0) of participants refused all examinations. Participants with STI symptoms were significantly more likely to give permission for full examination than asymptomatic participants (64.3 vs. 37.4%, adjusted odds ratio — AOR=3.6, 95%CI 2.4–5.5). Other factors significantly associated with uptake of a full examination in multivariate analysis included age (AOR=1.5 for ≥25 years), religion (AOR=1.7 for Afro-Brazilian, AOR=1.9 for other religions compared to no religion), and education (AOR=2.0 for higher-level). Conclusion: In the context of STI management, this study found limited acceptance of anogenital examinations among transgender women and travestis, with higher acceptance among those with STI symptoms.

ABSTRACT Objective: The efficacy of icodextrin versus glucose patients undergoing peritoneal dialysis remains unclear. The study was designed to compare the effects of once-daily long-dwell icodextrin versus glucose on markers of hypervolemia and survival among patients with kidney failure undergoing an unplanned initiation of automated peritoneal dialysis. Methods: This was a randomized, non-blinded, and prospective controlled study. Prevalent and stable patients undergoing automated peritoneal dialysis with a recent peritoneal equilibration test showing a dialysate/plasma creatinine of >0.50 were randomized to receive either 7.5% icodextrin or 2.5% glucose solution. Patients were evaluated at baseline (one month after the start of peritoneal dialysis), 3 months, and 6 months after inclusion. The peritoneal dialysis solution was used for at least 3 months, with a follow-up period of 24 months. Results: Thirty patients were enrolled. There were no baseline differences between the groups. During the study period, patients in the Icodextrin Group showed improvements in the phase angle and ultrafiltration, whereas there were no changes in the Glucose Group. Additionally, extracellular water was significantly lower in the Icodextrin Group at the end of the study than at baseline. No statistical differences between the two groups were observed in urine volume, ultrafiltration, extracellular water, phase angle, renal creatinine clearance, use of diuretics and antihypertensives, or blood pressure. During the 24-month follow-up, the number of events related to overall mortality was seven (Icodextrin Group, n=4; Glucose Group, n=3), with no difference between the groups for this outcome or technique survival. Conclusion: Icodextrin significantly improved ultrafiltration, extracellular water, and phase angle at the end of the study compared to baseline in patients on the urgent start of automated peritoneal dialysis. Registry of Clinical Trials: (www.ctri.nic.in) under the number RBR-97z4wh6.

RESUMO Objective Determinar a aceitabilidade e os fatores associados à realização do exame físico para detecção de infecções sexualmente transmissíveis (IST) sintomáticas em mulheres trans e travestis no Brasil. Métodos: Foram utilizados dados do “TransOdara”, estudo transversal de prevalência de IST, realizado em cinco capitais brasileiras (Campo Grande, Manaus, Porto Alegre, Salvador e São Paulo) entre dezembro de 2019 e julho de 2021. As 1.317 mulheres trans e travestis, com idade ≥18 anos, recrutadas por meio do método respondent-driven sampling passaram por entrevistas e responderam a um questionário estruturado. Foi ofertada consulta médica, incluindo realização de exame físico e coleta de amostras de vários locais para detectar diversas IST. Para a análise dos fatores associados à aceitabilidade do exame físico (geral, genital e anorretal), considerou-se as características sociodemográficas das participantes que permitiram a sua realização. Resultados: A maioria (65,4%; intervalo de confiança – IC95% 62,7–68,0) concedeu permissão para o exame geral (incluindo orofaríngeo), com permissão concedida em menor proporção para os exames genitais (42,3%; IC95% 39,6–46,0) ou anorretais (42,1%; IC95% 39,4–44,9). No geral, 34,4% (IC95% 31,8–37,0) delas recusaram todos os exames. As participantes com sintomas de IST foram significativamente mais propensas a conceder permissão para o exame completo do que as participantes assintomáticas (64,3 vs 37,4%, odds ratio ajustado – AOR=3,6, IC95% 2,4–5,5). Os fatores significativamente associados à aceitabilidade do exame completo na análise multivariada incluíram idade (AOR=1,5 para ≥25 anos), religião (AOR=2,0 para afro-brasileiras, AOR=1,9 para outras religiões em comparação com nenhuma religião) e nível de escolaridade (AOR=2,0 para nível superior). Conclusão: No contexto do manejo de IST, nós observamos aceitação limitada de exames anogenitais entre mulheres trans e travestis, com maior aceitação entre aquelas com sintomas de IST.

ABSTRACT Objective This study aimed to determine the acceptability and factors associated with uptake of a physical examination for the detection of symptomatic sexually transmitted infections (STIs) by transgender women and travestis in Brazil. Methods: TransOdara was a multi-centric, cross-sectional STI prevalence study conducted among transgender women and travestis in five capital cities (Campo Grande, Manaus, Porto Alegre, Salvador and São Paulo) representing all Brazilian regions, between December 2019 and July 2021. A total of 1,317 self-identified transgender women and travestis aged ≥18 years were recruited using respondent-driven sampling and responded to a standard questionnaire. A medical consultation was offered including a physical examination and collection of samples from multiple sites to detect various STIs. Factors associated with uptake were investigated by reviewing demographic characteristics of participants who gave permission for physical examination (general, genital, and anorectal). Results: Most participants (65.4%, 95% confidence interval — 95%CI 62.7–68.0) gave permission for a general examination (including oropharyngeal), with fewer permitting genital (42.3%, 95%CI 39.6–46.0) or anorectal (42.1%, 95%CI 39.4–44.9) examinations. Overall, 34.4% (95%CI 31.8–37.0) of participants refused all examinations. Participants with STI symptoms were significantly more likely to give permission for full examination than asymptomatic participants (64.3 vs. 37.4%, adjusted odds ratio — AOR=3.6, 95%CI 2.4–5.5). Other factors significantly associated with uptake of a full examination in multivariate analysis included age (AOR=1.5 for ≥25 years), religion (AOR=1.7 for Afro-Brazilian, AOR=1.9 for other religions compared to no religion), and education (AOR=2.0 for higher-level). Conclusion: In the context of STI management, this study found limited acceptance of anogenital examinations among transgender women and travestis, with higher acceptance among those with STI symptoms.

The aim of this study is evaluate the efficacy of 904 nm laser diode in bone regeneration in the bone defect in diabetic rats. Six groups of 10 male Wistar rats and 2 mm bone defects drilled on the left and right tibia were used. The diabetic animals were treated with streptozotocin (40 mg/kg, i.v.). We compared the diode laser doses of treatment of bone defects 50 w 4 J/cm and 100 w 4J/. The right tibia was used for immunohistochemical analysis with the apoptosis markers XIAP and Caspase-3 and the left tibia was submitted to computer tomography (CT). Caspase-3 marker showed greater amount of apoptosis in all the untreated groups compared to both laser treatments. There was no statistical significance for XIAP marker. CT scan showed improvement of bone defect area and volume in both laser treated groups, control and diabetic. Therefore the low intensity laser therapy was effective in accelerating bone repair in both, control and diabetic groups. It was evidenced in our study that diabetes influences bone repair negatively.

Los objetivos de este estudio fueron evaluar la eficacia del láser diodo de 904 nm en la regeneración ósea del defecto óseo en ratas diabéticas. Se utilizaron seis grupos de 10 ratas Wistar macho y se generó un defecto óseo de 2 mm en las tibias izquierda y derecha de los animales. El animal diabético fue generado con estreptozotocina (40 mg / kg, i.v.). Se compararon las dosis de tratamiento de los defectos óseos con láser de diodo de 50 w - 4 J / cm y 100w - 4 J /. La tibia derecha fue utilizada para el análisis inmunohistoquímico con los marcadores de apoptosis XIAP y Caspasa-3 y la tibia izquierda fue sometida a tomografía computarizada. El marcador caspasa-3 mostró mayor cantidad de apoptosis en todos los grupos no tratados en comparación con ambos tratamientos con láser. No hubo significación estadística para el marcador XIAP. La tomografía computarizada mostró una mejoría del área y el volumen de los defectos óseos en ambos grupos tratados con láser, control y diabéticos. Por lo tanto, la terapia con láser de baja intensidad fue eficaz en la aceleración de la reparación ósea tanto en los grupos control como en los diabéticos. Se evidenció en nuestro estudio que la diabetes afecta negativamente la reparación ósea.