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Abstract Background Genes and their variants associated with environmental factors contribute to the development of the hypertensive phenotype. The G protein beta 3 subunit gene (GNB3) is involved in the intracellular signaling process, and its variants have been related to susceptibility to arterial hypertension. Objective To determine the association of the GNB3 variant (rs5443:C>T) with arterial hypertension, biochemical parameters, age, and obesity in hypertensive and normotensive individuals from Ouro Preto, Minas Gerais, Brazil. Method The identification of variants was performed by real-time PCR, using the TaqMan® system, in 310 samples (155 hypertensive and 155 normotensive). Biochemical analyses (renal function, lipid profile and glycemia) were performed from the serum using UV/Vis spectrophotometry and ion-selective electrode. A multiple logistic regression model was used to identify factors associated with arterial hypertension. The analysis of continuous variables with normal distribution was performed using the unpaired Student’s t test; non-normal data were analyzed using Mann-Whitney. P < 0.05 was considered significant. Results The rs5443:C>T variant was not associated with arterial hypertension in the evaluated population (p = 0.88). Regarding biochemical measures, the T allele was associated with high levels of triglycerides, glucose and uric acid in hypertensive individuals (p < 0.05). Conclusion These results show the importance of genetic diagnosis to prevent the causes and consequences of diseases and imply that the GNB3 rs5443:C>T variant may be associated with changes in the biochemical profile in hypertensive individuals.

Resumo Fundamento Genes e suas variantes associadas a fatores ambientais contribuem para o desenvolvimento do fenótipo hipertenso. O gene da subunidade beta 3 da proteína G ( GNB3 ) está envolvido no processo de sinalização intracelular e suas variantes têm sido relacionadas à suscetibilidade à hipertensão arterial. Objetivo Determinar a associação da variante GNB3 (rs5443:C>T) com a hipertensão arterial, parâmetros bioquímicos, idade e obesidade em indivíduos hipertensos e normotensos de Ouro Preto, Minas Gerais. Método A identificação das variantes foi realizada por PCR em tempo real, utilizando o sistema TaqMan®, em amostras de 310 pacientes (155 hipertensos e 155 normotensos). Análises bioquímicas (função renal, perfil lipídico e glicemia) foram realizadas a partir do soro por meio de espectrofotometria UV/Vis e eletrodo íon-seletivo. Foi utilizado um modelo de regressão logística múltipla para identificar fatores associados à hipertensão arterial. A análise das variáveis contínuas com distribuição normal foi realizada usando o teste t de Student não pareado; dados não normais foram analisados usando o teste de Mann-Whitney. Valores de p < 0,05 foram considerados significativos. Resultados A variante rs5443:C>T não esteve associada à hipertensão arterial na população avaliada (p = 0,88). Em relação às medidas bioquímicas, o alelo T esteve associado a níveis elevados de triglicerídeos, glicose e ácido úrico em indivíduos hipertensos (p < 0,05). Conclusão Os presentes resultados mostram a importância do diagnóstico genético para prevenir as causas e consequências de doenças e sugerem que a variante GNB3 rs5443:C>T pode estar associada a alterações no perfil bioquímico em indivíduos hipertensos.

https://doi.org/10.36660/abc.20230396

Nijmegen breakage syndrome: The importance of follow-up
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Leite, Sara

; Lemos, Cláudia

; Dias, Rita

; Faria, Raquel

; Marques, Laura

Nascer e Crescer

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Set 2023, Volume 32 Nº 3 Páginas 214 - 216

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A síndrome de quebras de Nijmegen (NBS) é uma doença genética rara que ocorre devido à presença de variantes patogénicas no gene NBN, herdado de forma autossómica recessiva. Esta condição leva à reparação inadequada do DNA e caracteriza-se por imunodeficiência com infeções pulmonares recorrentes, hipersensibilidade à radiação e predisposição para neoplasias, particularmente de origem linfoide. As características fenotípicas principais são a microcefalia grave, que influencia o fenótipo facial, com andar médio da face proeminente e retrognatismo. A perturbação ligeira a moderada do desenvolvimento é frequente e os doentes do sexo feminino geralmente desenvolvem insuficiência ovárica primária. O diagnóstico requer um elevado índice de suspeição e pode ser confirmado por análise genética. São apresentados dois casos de síndrome de quebras de Nijmegen seguidos num hospital terciário.

Abstract Nijmegen breakage syndrome (NBS) is a rare genetic disorder caused by mutations in the NBN gene, which is inherited in an autosomal recessive pattern. The condition results in inadequate DNA repair and is characterized by immunodeficiency with recurrent sinopulmonary infections, increased radiosensitivity, and predisposition to malignancy, particularly of lymphoid origin. The main clinical feature is progressive and severe microcephaly, which affects the facial phenotype, characterized by prominent midface, sloping forehead, and retrognathia. Mild to moderate intellectual impairment is often present and female patients usually develop primary ovarian failure. The diagnosis requires a high index of suspicion and is confirmed by molecular genetic testing. Herein are presented two cases of Nijmegen breakage syndrome followed in a tertiary center.

https://doi.org/10.25753/birthgrowthmj.v32.i3.25758

Molecular mimicry between Zika virus and central nervous system inflammatory demyelinating disorders: the role of NS5 Zika virus epitope and PLP autoantigens
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França, Laise Carolina

; Fontes-Dantas, Fabrícia Lima

; Garcia, Diogo Gomes

; Araújo, Amanda Dutra de

; Gonçalves, João Paulo da Costa

; Rêgo, Cláudia Cecília da Silva

; Silva, Elielson Veloso da

; Nascimento, Osvaldo José Moreira do

; Lopes, Fernanda Cristina Rueda

; Herlinger, Alice Laschuk

; Aguiar, Renato Santana de

; Ferreira Junior, Orlando da Costa

; Figueira, Fernando Faria Andrade

; Souza, Jorge Paes Barreto Marcondes de

; Mesquita, Joelma Freire De

; Alves-Leon, Soniza Vieira

Arquivos de Neuro-Psiquiatria

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Abr 2023, Volume 81 Nº 4 Páginas 357 - 368

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Background Evidence indicates a strong link between Zika virus (ZikV) and neurological complications. Acute myelitis, optic neuritis, polyneuropathy, and encephalomyelitis that mimic inflammatory idiopathic demyelination disorders (HDD) after ZikV infection have been reported in Brazil. Objective The present study aims to investigate the possible occurrence of molecular mimicry between ZikV antigens and Multiple Sclerosis (MS) autoantigens, the most frequent HDD of the central nervous system (CNS). Methods A retrospective cohort study with 305 patients admitted due to suspected arbovirus infection in Rio de Janeiro was performed, all subjects were submitted to neurological examination, and a biological sample was collected for serologic and molecular diagnostic. Bioinformatics tools were used to analyze the peptides shared between ZikV antigens and MS autoantigens. Results Of 305 patients, twenty-six were positive for ZikV and 4 presented IDD patterns found in MS cases. Sequence homology comparisons by bioinformatics approach between NS5 ZikV and PLP MS protein revealed a homology of 5/6 consecutive amino acids (CSSVPV/CSAVPV) with 83% identity, deducing a molecular mimicry. Analysis of the 3D structures revealed a similar conformation with alpha helix presentation. Conclusions Molecular mimicry between NS5 Zika virus antigen and PLP MS autoantigens emerge as a possible mechanism for IDD spectrum in genetically susceptible individuals.

Resumo Antecedentes Evidências indicam uma forte ligação entre o vírus Zika (ZikV) e complicações neurológicas. Mielite aguda, neurite óptica, polineuropatia e encefalomielite que mimetizam distúrbios inflamatórios de desmielinização idiopáticos (DDII) após infecção por ZikV têm sido relatadas no Brasil. Obejtivo O presente estudo tem como objetivo investigar a possível ocorrência de mimetismo molecular entre antígenos do ZikV e autoantígenos da Esclerose Múltipla (EM), a DDII mais frequente do sistema nervoso central (SNC). Métodos Foi realizado um estudo de coorte retrospectivo com 305 pacientes internados por suspeita de infecção por arbovirus no Rio de Janeiro, todos os indivíduos foram submetidos a exame neurológico e coleta de amostra biológica para diagnóstico sorológico e molecular. Ferramentas de bioinformática foram usadas para analisar os peptídeos compartilhados entre antígenos do ZikV e autoantígenos da EM. Resultados Dos 305 pacientes, vinte e seis foram positivos para ZikV e 4 apresentaram padrão IDD encontrado em casos de EM. As comparações de homologia de sequência por abordagem de bioinformática entre a proteína NS5 ZikV e PLP EM revelaram uma homologia de 5/6 aminoácidos consecutivos (CSSVPV/CSAVPV) com 83% de identidade, deduzindo um mimetismo molecular. A análise das estruturas 3D revelou uma conformação semelhante com apresentação em alfa-hélice. Conclusões O mimetismo molecular entre o antígeno NS5 do vírus Zika e o autoantígeno PLP da EM surge como um possível mecanismo para o espectro IDD em indivíduos geneticamente suscetíveis.

https://doi.org/10.1055/s-0043-1768698

Dietary pattern in women with polycystic ovary syndrome with and without associated non-alcoholic fatty liver disease: A cross-sectional study
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Guimarães, Thais Cristine Moura

; Taranto, Daniela Oliveira de Lima

; Couto, Claudia Alves

; Nardelli, Mateus Jorge

; Cândido, Ana Lucia

; Hott, Cristina de Almeida

; Anastácio, Lucilene Rezende

; Reis, Fernando M.

; Rocha, Ana Luiza Lunardi

; Faria, Luciana Costa

Clinics

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2023, Volume 78 elocation 100288

Resumo: En | Texto: En | PDF: En

Abstract Introduction Women with Polycystic Ovary Syndrome (PCOS) have a higher prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) than the general population. PCOS and NAFLD have common metabolic risk factors, however, the role of diet in NAFLD development is still uncertain in PCOS women. Objective To evaluate and compare the dietary patterns and nutritional intake in patients with PCOS with and without NAFLD. Method Cross-sectional study that included patients with PCOS diagnosed according to Rotterdam criteria. All participants were submitted to abdominal ultrasound to investigate liver steatosis. Dietary profile was assessed by 24-hour food recall (24hR), and Food Frequency Questionnaire (FFQ). Diet quality was assessed by the Healthy Eating Index (HEI) adapted for the Brazilian population. Physical activity practice was also assessed. Results 87 participants were included (average age 35.2 ± 5.7 years), among whom, 67 (77%) had NAFLD. The group with PCOS and NAFLD presented higher body mass index (BMI) (34.9 ± 4.5 vs. 30.4 ± 4.9 kg/m2; p = 0.001), Waist Circumference (WC) (103 [97‒113] vs. 95 [87.5‒100] cm; p < 0.001) and were considered physically active less frequently than those without NAFLD (34.3% vs. 60%; p = 0.04). Food intake and dietary patterns assessed by 24hR, FFQ and HEI presented no difference between the groups. Conclusions PCOS women with coexistent NAFLD had higher BMI, WC and were less physically active than those without NAFLD. Dietary evaluation showed that PCOS women with NAFLD had no significant difference in macro and micronutrients or food group intake and diet quality in comparison to those without NAFLD.

https://doi.org/10.1016/j.clinsp.2023.100288

Knowledge about human papillomavirus transmission and prevention among physicians in Rio de Janeiro state, Brazil
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Mello, Victor Mendel da Silva

; Santos, Vitoria Carvalho Guimarães dos

; Baptista, Aimée Denzeler

; Fonseca, Sandra Costa

; Faria, Carlos Augusto

; Vitral, Claudia Lamarca

; Cavalcanti, Silvia

Revista da Associação Médica Brasileira

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2023, Volume 69 Nº 4 elocation e20220291

Resumo: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: This study aimed to assess physicians’ knowledge about human papillomavirus infection and its prevention. METHODS: Descriptive web-based survey with 15 objective questions targeted to physicians affiliated with the Regional Council of Medicine from Rio de Janeiro state, Brazil. Participants were invited by e-mail and the Council social networks, between January and December 2019. RESULTS: The study sample had 623 participants, with a median age of 45 years, predominantly women (63%). The most frequent specialties were Obstetrics and Gynecology (21.1%), Pediatrics (11.2%), and Internists (10.5%). Concerning human papillomavirus knowledge, 27.9% of the participants were able to identify accurately all possible forms of transmission, and none of them could recognize all the risk factors of infection. Nevertheless, 95% recognized that asymptomatic infection could occur in both sexes. Regarding knowledge about clinical manifestations, diagnosis, and screening, only 46.5% were able to identify all human papillomavirus-related cancers, 42.6% were aware of the periodicity of Pap smears, and 39.4% indicated that serological test was not adequate for diagnosis. The recommended age group for human papillomavirus vaccination was recognized by 94% of the participants, as well as the need for a Pap smear and the use of condoms, even after vaccination. CONCLUSIONS: There is good knowledge about prevention and screening for human papillomavirus infections; many gaps were identified regarding transmission, risk factors, and associated diseases among physicians in Rio de Janeiro state.

https://doi.org/10.1590/1806-9282.20220291

Elementary school teachers’ knowledge and attitudes toward emergency management of traumatic dental injuries
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KNEITZ, Fernanda Bello

; SCALIONI, Flávia Almeida Ribeiro

; TAVARES, Luciana Cláudia Diniz

; CAMPOS, Marcio José da Silva

; CARRADA, Camila Faria

; MACHADO, Fernanda Campos

Brazilian Oral Research

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2023, Volume 37 elocation e073

Resumo: En | Texto: En | PDF: En

Abstract The consequences of traumatic dental injuries can be even more serious when their emergency management procedures are inadequate. Since traumatic accidents frequently occur at school, it is crucial that teachers be knowledgeable enough to assist an injured child. This study aimed to assess the knowledge and attitudes of the elementary school teachers of a Brazilian city toward dental trauma in permanent teeth, and its emergency practices. A combination of convenience and snowball sampling methods was used. An online questionnaire was distributed through social media, consisting of three parts: demographic characteristics and professional information; previous experiences and attitudes toward dental trauma; teachers’ knowledge of this subject. Descriptive and statistical analyses were carried out. Pearson chi-squared test (p < 0.05) was used. A total of 217 teachers participated in the study. The power of the sample was 95%. Half of the teachers had already witnessed a dental trauma incident involving students, and 70.5% never received any information on the subject. The teachers who were provided previous information were the ones who opted to search for the tooth fragment (p=0.036) in cases of crown fracture, and for the lost tooth (p = 0.025) in cases of avulsion. They were also the ones who chose to wash the tooth in running water (p = 0.018), and look for a dentist in the first 30 or 60 minutes after the trauma (p = 0.026). Most of the teachers assessed did not have adequate knowledge of dental trauma. Having previous information was associated with more assertive practices in trauma management.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0073

Statistical Analysis of the Chemical Composition of Concrete Slurry Waste: A Case Study of Sedimentation Tanks from Concrete Batching Plants in Manaus-Brazil
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Guimarães, Jéssica Raíssa M.

; Faria, Yves Nathan M. de

; Oliveira, Mateus F. de

; Manzato, Lizandro

; Silva, Cláudia C.

Journal of the Brazilian Chemical Society

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2023, Volume 34 Nº 9 Páginas 1224 - 1235

Resumo: En | Texto: En | PDF: En

Concrete slurry waste is a material removed from sedimentation tanks that receive water used to wash concrete mixer trucks and patios of concrete batching plants (CBP). The objectives of this study were to determine the chemical composition of this residue from three different producers, in three consecutive months and at different collection points using wavelength dispersive X-ray fluorescence, investigate the inconstancy of content through analysis of variance, compare the qualitative and quantitative results with the literature and discuss the possibility of inserting the material in the proposal of different authors. Twenty-two oxides and elements were identified; among them, five showed their incidence in a punctual way. The analysis of variance showed that there are significant differences in the concentration of components between batching plants, months and collection points. The comparison with the literature showed that CaO, Al2O3 and SiO2 are the majority, both in the samples under study and in the samples from different authors. However, the average amounts of CaO are higher in the waste sludge from the concrete batching plants in question and, consequently, if this material were reused in the same proposals as the authors, the products would possibly present different characteristics and performance.

https://doi.org/10.21577/0103-5053.20230034

Brazilian evidence-based guideline for screening, diagnosis, treatment, and follow-up of metabolic dysfunction-associated steatotic liver disease (MASLD) in adult individuals with overweight or obesity: A joint position statement from the Brazilian Society of Endocrinology and Metabolism (SBEM), Brazilian Society of Hepatology (SBH), and Brazilian Association for the Study of Obesity and Metabolic Syndrome (Abeso)
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Moreira, Rodrigo Oliveira

; Valerio, Cynthia Melissa

; Villela-Nogueira, Cristiane Alves

; Cercato, Cintia

; Gerchman, Fernando

; Lottenberg, Ana Maria Pita

; Godoy-Matos, Amélio Fernando

; Oliveira, Ricardo de Andrade

; Mello, Carlos Eduardo Brandão

; Álvares-da-Silva, Mário Reis

; Leite, Nathalie Carvalho

; Cotrim, Helma Pinchemel

; Parisi, Edison Roberto

; Silva, Giovanni Faria

; Miranda, Paulo Augusto Carvalho

; Halpern, Bruno

; Oliveira, Claudia Pinto

Archives of Endocrinology and Metabolism

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2023, Volume 67 Nº 6 elocation e230123

Resumo: En | Texto: En | PDF: En

ABSTRACT Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as Nonalcoholic fatty liver disease (NAFLD), is one of the most common hepatic diseases in individuals with overweight or obesity. In this context, a panel of experts from three medical societies was organized to develop an evidence-based guideline on the screening, diagnosis, treatment, and follow-up of MASLD. Material and methods: A MEDLINE search was performed to identify randomized clinical trials, meta-analyses, cohort studies, observational studies, and other relevant studies on NAFLD. In the absence of studies on a certain topic or when the quality of the study was not adequate, the opinion of experts was adopted. Classes of Recommendation and Levels of Evidence were determined using prespecified criteria. Results: Based on the literature review, 48 specific recommendations were elaborated, including 11 on screening and diagnosis, 9 on follow-up, 14 on nonpharmacologic treatment, and 14 on pharmacologic and surgical treatment. Conclusions: A literature search allowed the development of evidence-based guidelines on the screening, diagnosis, treatment, and follow-up of MASLD in individuals with overweight or obesity.

https://doi.org/10.20945/2359-4292-2023-0123

Despublicização e resistência contra o “Escola sem Partido” na Câmara dos Deputados
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Resende, Marcos Paulo Dias Leite

; Faria, Cláudia Feres

Revista Brasileira de Ciência Política

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2023, Nº 42 elocation e269426

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract: This article investigates the discourse and actions of political and social actors who have struggled against the conservative and de-publicizing agendas of the “Escola Sem Partido” (“Schools Without Parties”) countermovement. The analysis of speeches in the Special Committee of “Escola Sem Partido”, in the Brazilian Chamber of Deputies, shows that the discursive strategies of representatives of movements and countermovement are similar to each other. Scientific, legal and normative arguments were mobilized to defend opposing policy agendas. The analysis of the speech, actors and voting dynamics in this arena shows that the regimental obstruction, as well as the judicialization, were the main strategies mobilized by the coalition against the “Escola Sem Partido” to block the countermovement agenda on education policy.

Resumen: Este artículo investiga los argumentos y estrategias de acción de los actores políticos y sociales que resistieron el embate del movimiento Escola sem Partido, entendido como un contramovimiento en defensa de la despublicización de la política educativa. Mediante el análisis del contenido de los discursos pronunciados en la Comisión Especial de Escola sem Partido, en la Cámara de Diputados de Brasil, identificamos que tanto representantes de movimientos como de contramovimientos utilizan discursos similares, basados en argumentos científicos, jurídicos y normativos, para defender agendas contrarias. El análisis de declaraciones, actores, así como la dinámica de votación en esta Comisión Especial, muestra que la obstrucción regimental y la judicialización constituyeron las principales estrategias movilizadas por la coalición contra la Escola sem Partido para frenar los lineamientos despublicitarios de la política educativa.

Resumo: Este artigo investiga os argumentos e as estratégias de ação dos atores políticos e sociais que resistiram às investidas do movimento Escola sem Partido, compreendido como um contramovimento em defesa da “despublicização” da política de Educação. Por meio da análise do conteúdo dos discursos proferidos na Comissão Especial do Escola sem Partido, na Câmara dos Deputados, identificamos que ambos, representantes dos movimentos e dos contramovimentos, utilizam discursos similares, baseados em argumentos científicos, legais e normativos, para defenderem pautas contrárias. A análise dos proferimentos, atores, assim como da dinâmica de votação nesta Comissão Especial, mostra que a obstrução regimental e a judicialização constituíram as principais estratégias mobilizadas pela coalizão contrária ao Escola sem Partido para barrar as pautas despublicizantes sobre a política educacional.

https://doi.org/10.1590/0103-3352.2023.42.269426

10.

Control of the root lesion Pratylenchus penetrans - the effect of nematicidal activity of plant-derived compounds
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Barbosa, Pedro

; Faria, Jorge M.S.

; Figueiredo, Ana Cristina

; Mota, Manuel

; Vicente, Cláudia S.L.

Revista de Ciências Agrárias

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Dez 2022, Volume 45 Nº 4 Páginas 1061 - 1070

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O nemátode das lesões radiculares, Pratylenchus penetrans, é um dos fitoparasitas mais destrutivo, responsável por perdas a nível mundial num significativo número de plantas hospedeiras. O controlo químico destes organismos baseia-se em fumigantes e não fumigantes, que providenciam uma protecção sistémica. Tais métodos de controlo são dispendiosos e prejudiciais quer para o ambiente quer para os humanos. Os compostos produzidos naturalmente pelas plantas poderão desempenhar um papel importante no controlo de nemátodes. A actividade nematicida de 8 compostos que ocorrem naturalmente em plantas, de duas classes de compostos, foi avaliada a 2 mg/mL durante 24 h. Os ensaios foram efectuados segundo a metodologia de contacto directo usualmente empregue. P. penetrans revelou-se extremamente insensível aos compostos testados com valores de mortalidade compreendidos entre 1.0 e 5.8%. No nosso conhecimento, a actividade nematicida de 4 compostos fenólicos (catequina, ácido cafeico, ácido gálico e ácido gentísico) foi testada pela primeira vez em P. penetrans.

Abstract The root lesion nematode, Pratylenchus penetrans, is one of the most harmful plant parasites, responsible for worldwide productivity losses in a significant number of plant hosts. Generally, chemical control relies on synthetic compounds used through fumigation or direct contact, which offers a systemic protection. These control methods are costly and hazardous to the environment and to humans. Phytochemicals may play an important role in nematode control. The nematicidal activity of eight compounds that occur naturaly in plants, from two classes of compounds, was assessed at 2 mg/mL, for 24 h. Bioassays were performed following the standard direct contact methodology. P. penetrans was remarkably tolerant to the tested compounds, with mortality range between 1.0 and 5.8 %. To the best of our knowledge, the nematicidal activity of 4 phenolic compounds (catechin, caffeic acid, gallic acid and gentisic acid) was evaluated for the first time for P. penetrans.

https://doi.org/10.19084/rca.28749

11.

Plant-Nematode co-cultures in the screening of sustainable nematicides against soil-dweling parasitic nematodes of plants
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Faria, Jorge M. S.

; Vicente, Cláudia S. L.

; Rusinque, Leidy

; Camacho, M. João

; Inácio, Maria L.

Revista de Ciências Agrárias

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Dez 2022, Volume 45 Nº 4 Páginas 591 - 600

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo As doenças causadas pelos nemátodes fitoparasitas permanecem uma considerável limitação á produção agrícola global. Um crescente número substâncias activas, utilizadas em formulações nematicidas comerciais, têm sido proibidas por políticas comuns de gestão de pragas, devido a preocupações ambientais e de saúde humana. Muitas vezes, os pesticidas de substituição demonstram uma menor eficiência no campo, o que se reflete num decréscimo do rendimento e da produtividade agrícola. O desenvolvimento de novos biopesticidas de alta eficiência para o combate de pragas e doenças das culturas é urgente e permitirá dar resposta adequada à crescente necessidade de produtos agrícolas, respeitando as novas políticas ambientais. As co-culturas planta-nemátode permitem uma despistagem simultânea da eficiência nematodicida de um composto e da sua influência nos tecidos vegetais do hospedeiro, num sistema facilmente acessível que simula a infecção natural. O laboratório de Nematologia do INIAV encontra-se a desenvolver estes sistemas e foram já obtidos resultados preliminares para as co-culturas de Solanum lycopersicum com o nemátode Meloidogyne ethiopica e S. tuberosum com Globodera pallida. Em ensaios futuros outros nemátodes fitoparasitas serão avaliados, como os nemátodes das lesões da raíz (Pratylenchus penetrans) em raízes transgénicas de batata e do nemátode da madeira do pinheiro (Bursaphelenchus xylophilus) em rebentos in vitro de pinheiro (Pinus sp.).

Abstract The diseases caused by plant parasitic nematodes are still a serious constraint to modern global crop production. An increasing number of active compounds in commercial nematicidal formulations is being banned from use by common policies of pest management. Farmer communities report a low efficiency for the replacement pesticides, which reflects on crop yield and productivity. Novel sustainable biopesticides are urgently needed to cope with global food demands while respecting the most recent environmental policies. Plant-nematode co-cultures offer a stable biotechnological screening tool able to assess the active compound’s nematicidal activity and its effect on host tissues, simultaneously, in an easily accessible system that simulates natural infection. These systems are being developed and optimized at the Nematology laboratory of INIAV. Preliminary results were obtained for co-cultures of Solanum lycopersicum with the nematode Meloidogyne ethiopica and S. tuberosum with Globodera pallida. Future studies will target other plant parasitic nematodes, e.g., the root lesion nematodes (Pratylenchus penetrans) in transgenic roots of potato and the pinewood nematode (Bursaphelenchus xylophilus) on in vitro pine shoots (Pinus sp.).

https://doi.org/10.19084/rca.28556

12.

Assessment of the fat mass index in women recently diagnosed with gynecological tumors
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Brito, Lígia Zampieri de

; Murra, Mariana dos Santos

; Reis, Ricardo

; Faria, Sheilla de Oliveira

; Spexoto, Maria Claudia Bernardes

Nutrición Hospitalaria

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Abr 2022, Volume 39 Nº 2 Páginas 348 - 354

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Objectives: to evaluate the nutritional status and body composition of women with gynecological tumors and evaluate the fat mass index (FMI) as a complementary indicator for addressing the nutrition status. Methods: a cross-sectional study with women recently diagnosed with gynecological tumors. Nutritional status was assessed using conventional anthropometry and the Patient-Generated Subjective Global Assessment. For body composition, bioelectrical impedance was used. Results: a total of 158 women participated, most of them with excess weight and high body fat. The FMI showed a positive and significant correlation with body mass index, arm circumference, tricipital skinfold, and arm muscle circumference. Conclusion: women recently diagnosed with gynecological tumors had excess weight and high body fat. The FMI may be a potentially useful indicator to complement the assessment of nutritional status and help the multidisciplinary team to perform early clinical and nutritional interventions.

Resumen Objetivos: evaluar el estado Nutricional y la composición corporal de mujeres con tumores ginecológicos, y evaluar el índice de masa grasa (IMG) como indicador Nutricional complementario. Métodos: estudio transversal con mujeres diagnosticadas recientemente de tumores ginecológicos. El estado Nutricional se evaluó mediante la antropometría convencional y la Evaluación Global Subjetiva Generada por el Paciente. Para la composición corporal se utilizó la impedancia bioeléctrica. Resultados: participaron 158 mujeres, la mayoría con exceso de peso y grasa corporal alta. El IMG mostró una correlación positiva y significativa con el índice de masa corporal, la circunferencia del brazo, el pliegue cutáneo tricipital y la circunferencia de los músculos del brazo. Conclusión: las mujeres diagnosticadas recientemente con tumores ginecológicos presentaron exceso de peso y grasa corporal alta. El IMG puede ser un indicador potencialmente útil para complementar la evaluación del estado Nutricional y ayudar al equipo multidisciplinario a realizar intervenciones clínicas y Nutricionales tempranas.

https://doi.org/10.20960/nh.03641

13.

An empirically oriented analysis of deliberative and participatory systems: health and policy for women's councils and conferences in Minas Gerais
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Faria, Cláudia Feres

; Lins, Isabella Lourenço

Opinião Pública

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Mar 2022, Volume 28 Nº 1 Páginas 237 - 267

Resumo O artigo analisa se e como as conferências e conselhos de saúde e de políticas para as mulheres em Minas Gerais interagem para formar um sistema participativo e deliberativo nestas duas áreas de política. O artigo avalia analítica e empiricamente (1) como os atores, os temas e as normas atuam enquanto conectores desses fóruns e (2) se essas conexões promovem um sistema integrado em cada área de política. Para investigar as conexões entre as conferências e os conselhos utilizamos quatro técnicas de pesquisa diferentes: observações das reuniões dos conselhos e das conferências, análise de documentos, survey e entrevistas. As técnicas foram mobilizadas para comparar estes dois casos contrastantes. Como resultado da análise comparativa, argumentamos que a infraestrutura legal e política na qual as áreas de políticas estão imersas induz os conectores a funcionarem de forma sistêmica. A política de saúde, mais previsível jurídica e institucionalmente do que a política para as mulheres, garante condições mais favoráveis para os atores coordenarem suas ações, para os temas serem debatidos e veiculados, assim como para as normas serem contestadas e legitimadas. Desta forma, afirmamos que os recursos político-institucionais são fundamentais para que os conectores conformem um sistema participativo e deliberativo nas duas áreas de política analisadas.

This article analyzes whether and how conferences and councils on policies for health and women in Minas Gerais interact with each other to shape a participatory and deliberative system in these policy areas. Thus, the article analytically and empirically evaluates: (1) how actors, topics, and norms act as connectors of these forums in each policy area; (2) whether those connections promote an integrated system in each policy area. To investigate the connections among the forums, we proposed four different techniques: observations of council meetings and conferences, document analysis, surveys, and interviews. We mixed these techniques to compare these two contrasting cases. As a result of this comparative analysis, we argue that the legal and political infrastructure in which policies are immersed induces the connectors to work systemically. Health policy, which is legally and institutionally more predictable than policy for women, ensures more favorable conditions for the actors to coordinate their actions, for the topics to be debated and transmitted, and for the norms to be disputed and legitimized. Therefore, we claim that the political-institutional resources are significant for the connectors to shape a participatory and deliberative system in each policy area.

Resumen El artículo examina si, y cómo, los congresos y los consejos de políticas de salud y para las mujeres en Minas Gerais interactúan para formar un sistema participativo y deliberativo en estas áreas de política pública. El artículo evalúa analítica y empíricamente: (1) cómo los actores, los temas y las normas actúan como conectores de estos foros y (2) si estas conexiones promueven un sistema integrado en cada área de política. Para investigar las conexiones entre los foros, utilizamos cuatro técnicas de investigación diferentes: observaciones de las reuniones del consejo y de lo congresos, análisis de documentos, encuestas y entrevistas. Las técnicas fueron movilizadas para comparar estos dos casos contrastantes. Como resultado del análisis comparativo, sostenemos que la infraestructura jurídica y política en la que están inmersos los ámbitos políticos induce a los conectores a funcionar de forma sistémica. La política de salud, más previsible desde el punto de vista jurídico e institucional que la política para las mujeres, garantiza unas condiciones más favorables para que los actores coordinen sus acciones, para que los temas se debatan y se transmitan, y para que las normas se impugnen y se legitimen. Por lo tanto, afirmamos que los recursos político-institucionales son importantes para que los conectores se ajusten a un sistema participativo y deliberativo en cada área de política pública.

Résumé L'article analyse si et comment les conférences et conseils sur la santé et la politique envers les femmes au Minas Gerais interagissent pour former un système participatif et délibératif dans ces domaines politiques. L'article évalue de manière analytique et empirique (1) comment les acteurs, les thèmes et les normes agissent comme connecteurs de ces forums et (2) si ces connexions favorisent un système intégré dans chaque domaine politique. Pour étudier les liens entre les forums, nous avons utilisé quatre techniques de recherche différentes : l'observation des réunions du conseil et de la conférence, l'analyse des documents, l'enquête et les entretiens. Ces techniques ont été mobilisées pour comparer ces deux cas contrastés. À la suite de l'analyse comparative, nous soutenons que l'infrastructure juridique et politique dans laquelle les domaines politiques sont immergés incite les connecteurs à fonctionner de manière systémique. La politique de santé, qui est plus prévisible sur le plan juridique et institutionnel que la politique envers les femmes, assure des conditions plus favorables pour que les acteurs coordonnent leurs actions, pour que les questions soient débattues et transmises, et pour que les normes soient contestées et légitimées. Par conséquent, nous affirmons que les ressources politico-institutionnelles sont importantes pour que les connecteurs se conforment à un système participatif et délibératif dans chacun des domaines politiques analysés.

https://doi.org/10.1590/1807-01912022281237

14.

Guidelines on COVID-19 vaccination in patients with immune-mediated rheumatic diseases: a Brazilian Society of Rheumatology task force
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Tavares, Anna Carolina Faria Moreira Gomes

; Melo, Ana Karla Guedes de

; Cruz, Vítor Alves

; Souza, Viviane Angelina de

; Carvalho, Joana Starling de

; Machado, Ketty Lysie Libardi Lira

; Valadares, Lilian David de Azevedo

; Reis Neto, Edgard Torres dos

; Rezende, Rodrigo Poubel Vieira de

; Guimarães, Maria Fernanda Brandão de Resende

; Ferreira, Gilda Aparecida

; Braz, Alessandra de Sousa

; Vieira, Rejane Maria Rodrigues de Abreu

; Pinheiro, Marcelo de Medeiros

; Ribeiro, Sandra Lúcia Euzébio

; Bica, Blanca Elena Gomes Rios

; Baptista, Kátia Lino

; Costa, Izaias Pereira da

; Marques, Claudia Diniz Lopes

; Lopes, Maria Lúcia Lemos

; Martinez, José Eduardo

; Giorgi, Rina Dalva Neubarth

; Mota, Lícia Maria Henrique da

; Loures, Marcos Antônio Araújo da Rocha

; Paiva, Eduardo dos Santos

; Monticielo, Odirlei André

; Xavier, Ricardo Machado

; Kakehasi, Adriana Maria

; Pileggi, Gecilmara Cristina Salviato

Advances in Rheumatology

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2022, Volume 62 elocation 3

Resumo: En | Texto: En | PDF: En

Abstract Objective: To provide guidelines on the coronavirus disease 2019 (COVID-19) vaccination in patients with immune-mediated rheumatic diseases (IMRD) to rheumatologists considering specific scenarios of the daily practice based on the shared-making decision (SMD) process. Methods: A task force was constituted by 24 rheumatologists (panel members), with clinical and research expertise in immunizations and infectious diseases in immunocompromised patients, endorsed by the Brazilian Society of Rheumatology (BSR), to develop guidelines for COVID-19 vaccination in patients with IMRD. A consensus was built through the Delphi method and involved four rounds of anonymous voting, where five options were used to determine the level of agreement (LOA), based on the Likert Scale: (1) strongly disagree; (2) disagree, (3) neither agree nor disagree (neutral); (4) agree; and (5) strongly agree. Nineteen questions were addressed and discussed via teleconference to formulate the answers. In order to identify the relevant data on COVID-19 vaccines, a search with standardized descriptors and synonyms was performed on September 10th, 2021, of the MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and LILACS to identify studies of interest. We used the Newcastle–Ottawa Scale to assess the quality of nonrandomized studies. Results: All the nineteen questions-answers (Q&A) were approved by the BSR Task Force with more than 80% of panelists voting options 4—agree—and 5—strongly agree—, and a consensus was reached. These Guidelines were focused in SMD on the most appropriate timing for IMRD patients to get vaccinated to reach the adequate covid-19 vaccination response. Conclusion: These guidelines were developed by a BSR Task Force with a high LOA among panelists, based on the literature review of published studies and expert opinion for COVID-19 vaccination in IMRD patients. Noteworthy, in the pandemic period, up to the time of the review and the consensus process for this document, high-quality evidence was scarce. Thus, it is not a substitute for clinical judgment.

https://doi.org/10.1186/s42358-022-00234-7

15.

In vitro and in vivo Anti-leishmanial Potential of [Ag (PTA) 4 ]BF 4 and [Ag(HBPz 3 )(PPh 3 )] Silver Complexes
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Soldera, Pauline de Faria

; Chagas, Ana Flavia da Silva

; Brasil, Anny Maisa Vargas

; Comandolli-Wyrepkowski, Claudia Dantas

; Porchia, Marina

; Pereira, Antonia Maria Ramos Franco

Revista da Sociedade Brasileira de Medicina Tropical

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2022, Volume 55 elocation e0478-2021

Resumo: En | Texto: En | PDF: En

ABSTRACT Background: American tegumentary leishmaniasis is a parasitic disease known for being difficult to treat; therefore, the search for more effective therapeutic methods is necessary. The objective of this study was to evaluate the in vitro and in vivo antileishmanial activity of silver complexes [Ag(PTA)4]BF4 (Ag1) and [Ag(HBPz3)(PPh3)] (Ag2) against Leishmania (Leishmania) amazonensis [L. (L.) amazonensis] and Leishmania (Viannia) guyanensis. Methods: In vitro bioassays were performed to evaluate the activity of the complexes against promastigote and amastigote forms and evaluate their cytotoxicity. In vivo experiments were performed with hamsters (Mesocricetus auratus) infected and treated topically with two gels containing each metallic complex. Results: Both complexes reduced the number of viable parasites against the promastigote forms of L. (L.) amazonensis. Ag2 was mainly effective against the amastigote forms. The Ag2 complex did not present cellular cytotoxicity, and regarding the selectivity index, both complexes were considered acceptable, with Ag2 having the best selectivity index in murine peritoneal macrophages in relation to L. (L.) amazonensis. Ag2 showed better results in the topical treatment against infections caused by L. (L.) amazonensis, with a small reduction in the lesion volume after the 14th day of treatment and less parasitic load at the lesion site. Conclusions: Ag2 was more effective than Ag1 against L. (L.) amazonensis.

https://doi.org/10.1590/0037-8682-0478-2021

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