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Abstract Malaria is a disease caused by Plasmodium spp. protozoa. The ability of Plasmodium to develop resistance to current antimalarial drugs makes the study of chemotherapeutic alternatives extremely important. This study aimed to evaluate the antimalarial activity of compound 3286938 (1-(3-benzyloxy-4-methoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propan-1-one), which presents in its structure a 3,4,5-trimethoxyphenyl group, in vitro, using the W2 strain of P. falciparum and against circulating strains of P. vivax and P. falciparum from the state of Rondônia. The compound 3286938 obtained an IC50 of 24.4 µM against the W2 strain of P. falciparum, and against the circulating strains, it presented a median (MD)=38.7 µM for P. vivax and MD=6.7 µM for P. falciparum. As for toxicity, 3286938 showed CC50 > 500 µM for VERO and HepG2 strains with a selectivity index greater than 12.9, a ratio calculated for P. falciparum and P. vivax regarding Vero and HepG2 cells. The compound was not considered hemolytic in in vitro assays, thus indicating the specificity of its antiplasmodial action. Based on the results presented, and considering the unprecedented character of the compound, it can be concluded that 3286938 was shown to be promising for complementary in vitro and in vivo studies aiming to produce effective antiplasmodial action. spp protozoa important 328693 13benzyloxy4methoxyphenyl33,4,5trimethoxyphenylpropan1one, 13benzyloxy4methoxyphenyl3345trimethoxyphenylpropan1one benzyloxymethoxyphenyltrimethoxyphenylpropanone 1 3 benzyloxy 4 methoxy phenyl 3,4,5 trimethoxy propan one , 5 (1-(3-benzyloxy-4-methoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propan-1-one) 3,4,5trimethoxyphenyl 345trimethoxyphenyl trimethoxyphenyl group W P Rondônia IC IC5 244 24 24. MD=38.7 MD387 MD =38.7 38 7 (MD)=38. MD67 6 MD=6. toxicity CC CC5 50 HepG 129 12 9 12.9 cells assays action 32869 13benzyloxy4methoxyphenyl33 5trimethoxyphenylpropan1one methoxyphenyl trimethoxyphenylpropan 13benzyloxy4methoxyphenyl33,4,5trimethoxyphenylpropan1one 345 3,4, (1-(3-benzyloxy-4-methoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propan-1-one 5trimethoxyphenyl 2 MD=38. MD38 387 =38. (MD)=38 MD6 MD=6 12. 3286 benzyloxymethoxyphenyl 13benzyloxy4methoxyphenyl3 trimethoxyphenylpropanone 34 3,4 MD=38 MD3 =38 (MD)=3 MD= 328 13benzyloxy4methoxyphenyl 3, MD=3 =3 (MD)= 32 = (MD) (MD