ABSTRACT Introduction: By July 2023, Brazil had administered approximately 540 million COVID-19 vaccine doses. This study aimed to quantify wasted doses resulting from dead space in vaccine supplies. Methods: The vaccine supply was initially weighed, filled with distilled water, and expelled to simulate administration. Weighing it again after the application determined the dead space volume. Descriptive analyses calculated the waste rate/wasted dose count. Results: The estimated total number of wasted vaccine doses using supplies with the lowest dead space was 62,097,338. Conclusions: Syringe dead space is a crucial factor in dose wastage, directly influencing the number of wasted doses. Introduction 2023 54 COVID19 COVID 19 COVID-1 Methods weighed water administration volume ratewasted rate count Results 62097338 62 097 338 62,097,338 Conclusions wastage 202 5 COVID1 1 COVID- 6209733 6 09 33 62,097,33 20 620973 0 3 62,097,3 2 62097 62,097, 6209 62,097 620 62,09 62,0 62,

RESUMO Os polímeros utilizados para impressão 3D do tipo FFF apresentam uma sensibilidade muito grande às variações de temperatura, que vai desde o processo de fabricação até o uso do produto final. Essa é uma característica importante para o processo de impressão, porém, pode representar um fator limitante para sua utilização em ambientes com grandes variações de temperatura. Portanto, o presente trabalho teve como objetivo analisar o comportamento mecânico de corpos de provas de PLA (ácido polilático) fabricados por impressão 3D utilizando a tecnologia FFF (Fabricação por Filamento Fundido) e submetido às temperaturas de 5°C, 25°C e 45°C. Foram realizados testes de tração e flexão em três pontos em corpos de prova fabricados em três orientações diferentes (flat, on-edge e upright). Foi utilizado um equipamento constituído por uma câmara térmica e um sistema de controle de temperatura anexado a uma Máquina Universal de Ensaios. Os corpos de prova foram distribuídos em grupos experimentais de 5 unidades cada. Todos os parâmetros de impressão foram iguais para todos os grupos. O PLA à 5°C apresentou um aumento significativo do módulo de elasticidade e limite de escoamento, gerando um comportamento mais frágil. À 25°C, o comportamento mecânico foi semelhante à literatura. Por fim, à 45°C, foi observado uma queda na resistência e um aumento acentuado da plasticidade do PLA, devido à proximidade da temperatura de transição vítrea. Os corpos de prova impressos nas orientações flat e on-edge apresentaram desempenho mecânico similar, enquanto os corpos de prova impressos na orientação upright apresentaram os menores valores das propriedades mecânicas analisadas.

ABSTRACT Polymers used for 3D printing with FFF technology are very sensitive to temperature variations, which occurs from its manufacturing process to its final usage. This is an important characteristic for the printing process, however it can represent a limiting factor for its use in environments with large temperature variations. Therefore, this paper aimed to analyze the mechanical behavior of PLA (polylactic acid) specimens manufactured by 3D printing using the FFF (Fused Filament Fabrication) technology and subjected to temperatures of 5°C, 25°C and 45°C. Tensile and three-point bending tests were performed on specimens manufactured in three different orientations (flat, on-edge and upright). An equipment, consisting of a thermal chamber and a temperature control system attached to the Universal Testing Machine, was used to control the temperature in the environment where the specimens were subjected to the mechanical tests. The specimens were distributed in experimental groups of 5 units each. All printing parameters were the same for all groups. PLA at 5°C showed a significant increase in the modulus of elasticity and yield strength, causing a more fragile behavior. At 25°C the mechanical behavior was similar to the literature. Lastly, at 45°C, a decrease in strength and a high increase in PLA plasticity were observed, due to the proximity of the glass transition temperature. The specimens printed in the flat and on-edge orientations presented similar mechanical performance, while the ones printed in the upright orientation presented the lowest values of the analyzed mechanical properties.

This study evaluated the influence of an alternative surface treatment on the microshear bond strength (μsbs) of zirconia-based ceramic. Thirty-five zirconia disks were assigned to five groups according to the following treatments: Control (CO), glass and silane were not applied to the zirconia surface; G1, air blasted with 100μm glass beads + glaze + silane; G2, a gel containing 15% (by weight) glass beads applied to the ceramic surface + glaze + silane; G3, a gel containing 25% (by weight) glass beads applied to the ceramic surface + glaze + silane; and G4, a gel containing 50% (by weight) glass beads applied to the ceramic surface + glaze + silane. The specimens were built up using RelyX ARC®, according to the manufacturer’s recommendations, and inserted in an elastomeric mold with an inner diameter of 0.8 mm. The μsbs test was performed using a testing machine at a crosshead speed of 0.5 mm/min. ANOVA and Tukey’s test (p < 0.05) were applied to the bond strength values (in MPa). CO (15.6 ± 4.1) showed the lowest μsbs value. There were no statistical differences between the G1 (24.9 ± 7.4), G2 (24.9 ± 2.3), G3 (35.0 ± 10.3) and G4 (35.3 ± 6.0) experimental groups. Those groups submitted to surface treatments with higher concentrations of glass showed a lower frequency of adhesive failures. In conclusion, the glass application improved the interaction between the ceramic and the luting cement.

Objective: To compare, using photoelasticity, internal stress produced by USS II type screw with 5.2 and 6.2 mm external diameters, when submitted to three different pullout strengths. Methods: Two photoelastic models were especially made. The simulation was performed using loads of 1.8, 2.4 e 3.3 kgf.The fringe orders were evaluated around the screws. In all the models analyzed the shear stress were calculated. Results: Independently of the applied load, the smaller screw showed higher values of shear stress. Conclusion: According to the analysis performed, we observed that the place of highest stress was in the first thread of the lead, close to the head of the screws. Experimental study.

OBJETIVO: Analisar as tensões geradas no corpo vertebral L4 quando submetida à força de compressão, utilizando a técnica da fotoelasticidade de transmissão. MÉTODOS: Doze modelos fotoelásticos foram utilizados e divididos em três grupos, sendo cada grupo formado por quatro modelos, de acordo com a localização do corte sagital nas vértebras L4-L5 (cortes A, B e C). A simulação foi realizada utilizando uma força compressão de 15 N e as ordens de franjas foram avaliadas no corpo vertebral L4 utilizando o método de compensação de Tardy. RESULTADOS: A análise fotoelástica mostrou que em geral, as tensões se distribuíram de forma homogênea nos corpos vertebrais. As tensões no corte C foram maiores que no B, que por sua vez foram maiores que no corte A. CONCLUSÃO: A região posterior do corpo vertebral L4, principalmente no corte C, apresentou maiores concentrações de tensões, sendo assim, é a área mais susceptível à fratura vertebral e à espondilolistese. Análises econômicas e de decisão. Desenvolvimento de modelo econômico ou de decisão, Nível de evidência I.

OBJECTIVE: to analyze the shear forces on the vertebral body L4 when submitted to a compression force by means of transmission photoelasticity. METHODS: Twelve photoelastic models were divided into three groups, with four models per group, according to the positioning of the sagittal section vertebrae L4-L5 (sections A, B and C). The simulation was performed using a 15N compression force, and the fringe orders were evaluated in the vertebral body L4 by the Tardy compensation method. RESULTS: Photoelastic analysis showed, in general, a homogeneous distribution in the vertebral bodies. The shear forces were higher in section C than B, and higher in B than A. CONCLUSION: The posterior area of L4, mainly in section C, showed higher shear concentrations, corresponding to a more susceptible area for bone fracture and spondylolisthesis. Economic and Decision Analyses - Development of an Economic or Decision Model. Level I

A remodelação óssea pode ser estimulada por forças mecânicas presentes nas atividades físicas normais. Neste trabalho foi analisado o comportamento mecânico do terço proximal de fêmur de ratas submetidas à suspensão pela cauda e posterior treinamento em esteira. Sessenta e seis ratas da raça Wistar foram usadas. Primeiramente os animais foram criados por noventa dias e divididos em cinco grupos (dois controles e três experimentais). Os animais do grupo Controle I foram sacrificados com 118 dias de idade. No grupo S (suspenso) os animais foram suspensos pela cauda por 28 dias e sacrificados. No grupo Controle II os animais foram sacrificados com 139 dias de idade. No grupo S-L (suspenso-liberado) as ratas foram liberadas 21 dias após a suspensão. No grupo S-T (suspenso-treinado) após o período de suspensão os animais passaram por treinamento em esteira durante 21 dias. Para análise do comportamento mecânico do osso foi aplicada uma força vertical na cabeça femoral até a ruptura. A fratura foi analisada por raios-X. A suspensão causou um decréscimo da força máxima e, o treinamento e a liberação após a suspensão causaram a recuperação das propriedades mecânicas. Mas, o padrão de fratura não apresentou diferença entre os grupos experimentais.

Bone remodeling can be stimulated by mechanical forces present in normal physical activities. In the present research, we investigated the mechanical behavior of the proximal femur of rats previously maintained in tail suspension and later, submitted to physical exercise on a treadmill. Sixty-six Wistar rats were used. Firstly, the animals were raised until the age of ninety days and then divided into five groups (two control groups and three experimental groups). The animals allocated to Control I group were killed at 118 days of age. In the S group, the animals were suspended by tail for 28 days. In Control II group, the animals were killed at 139 days of age. In group S-L (suspended and released) the rats were kept free for 21 days after tail suspension. In group S-T (suspended and trained), after tail suspension period, the rats were trained in a treadmill for 21 days. For analysis of the mechanical behavior of the bone, force was applied on the femoral head until failure. The fracture was evaluated by x-ray. Suspension caused a decrease of the maximum load and, treadmill training and post-suspension release caused the recovery of mechanical properties. But, the fracture line pattern did not show any difference among the experimental groups.