Abstract Background New-onset atrial fibrillation (NOAF) occurs in patients hospitalized due to COVID-19. It is still unknown whether clinical and laboratory data assessed upon hospital admission have predictive value for NOAF. Objectives To analyze, upon hospital admission, variables with predictive potential for the occurrence of NOAF in patients with COVID-19 pneumonia. Methods Observational, retrospective, case-control study. Electronic medical reports of consecutive patients, 60 years of age or older, hospitalized due to COVID-19 pneumonia between March 1st and July 15th, 2020, were reviewed. Non-paired Student or chi-squared tests compared variables. A Cox proportional hazard model was employed to identify independent predictors of NOAF. P value < 0.05 was considered statistically significant. Results Among 667 patients hospitalized due to COVID-19, 201 (30.1%) fulfilled the inclusion criteria. NOAF was documented in 29 patients (14.4%), composing group 1. Group 2 was composed of 162 patients without NOAF. Ten patients were excluded due to the AF rhythm upon hospital admission. In groups 1 and 2, there were differences in overall in-hospital survival rate (24.1 % vs. 67.9%; p<0.001), length of stay in ICU (11.1 ± 10.5 days vs. 4.9 ± 7.5 days; p=0.004) and need for mechanical ventilation rate (82.9% vs. 32.7%; p<0.001). In the Cox model, age > 71 y/o (HR=6.8; p<0.001), total leukocyte count ≤ 7,720 cels.μL-¹ (HR=6.6; p<0.001), serum [Na+] ≤ 137 mEq.L-¹ (HR=5.0; p=0.001), SAPS3 score > 55 (HR=5.6; p=0.002), and disorientation (HR=2.5; p=0.04) on admission were independent predictors of NOAF. Conclusion NOAF is a common arrhythmia in elderly hospitalized patients with COVID-19 pneumonia. Clinical and laboratory parameters evaluated on admission have a predictive value for the occurrence of NOAF during hospitalization. Newonset New onset (NOAF COVID19. COVID19 COVID 19. 19 analyze COVID-1 Observational retrospective casecontrol case control study 6 older st 15th th 2020 reviewed Nonpaired Non paired chisquared chi squared 005 0 05 0.0 significant 66 COVID19, 19, 20 30.1% 301 30 (30.1% criteria 14.4%, 144 14.4% , 14 4 (14.4%) 16 inhospital 24.1 241 24 (24. vs 67.9% 679 67 9 p<0.001, p0001 p p<0.001 001 p<0.001) 11.1 111 11 (11. 105 10 5 10. 49 4. 75 7 7. p=0.004 p0004 004 82.9% 829 82 (82.9 32.7% 327 32 p<0.001. . yo y o HR=6.8 HR68 HR 8 (HR=6.8 7720 720 7,72 cels.μL¹ celsμL¹ celsμL cels.μL ¹ cels μL cels.μL- HR=6.6 HR66 (HR=6.6 Na+ Na [Na+ 13 mEq.L¹ mEqL¹ mEqL mEq.L mEq L mEq.L- HR=5.0 HR50 (HR=5.0 p=0.001, p=0.001 p=0.001) SAPS HR=5.6 HR56 (HR=5.6 p=0.002, p0002 p=0.002 002 p=0.002) HR=2.5 HR25 (HR=2.5 p=0.04 p004 04 hospitalization COVID1 COVID- 202 00 0. 30.1 3 (30.1 14.4 (14.4% 24. (24 67.9 p000 p<0.00 11. (11 p=0.00 82.9 (82. 32.7 HR=6. HR6 (HR=6. 772 72 7,7 μL¹ [Na L¹ HR=5. HR5 (HR=5. HR=2. HR2 (HR=2. p=0.0 p00 30. (30. 14. (14.4 (2 67. p<0.0 (1 82. (82 32. HR=6 (HR=6 77 7, HR=5 (HR=5 HR=2 (HR=2 p=0. p0 (30 (14. ( p<0. (8 HR= (HR= p=0 (3 (14 p<0 (HR p= p<

Resumo Fundamento Fibrilação atrial nova (FAN) ocorre em pacientes internados por COVID-19. Há controvérsias quanto ao valor preditivo de dados clínicos e laboratoriais à admissão hospitalar para ocorrência de FAN. Objetivos Analisar, à admissão hospitalar, variáveis com potencial preditivo para ocorrência de FAN em pacientes com pneumonia por COVID-19. Método Estudo observacional, retrospectivo, caso-controle. Foram avaliados prontuários eletrônicos de pacientes consecutivos ≥ 60 anos, hospitalizados com pneumonia por COVID-19 entre 1º de março e 15 de julho de 2020. Comparações feitas pelos testes `t’ de Student ou qui-quadrado. Foi empregado modelo de risco proporcional de Cox para identificação de preditores de FAN. Considerou-se o valor de p < 0,05 como estatisticamente significativo. Resultados Entre 667 pacientes internados por COVID-19, 201 (30,1%) foram incluídos. FAN foi documentada em 29 pacientes (14,4%) (grupo 1). Grupo 2 foi composto por 162 pacientes que não apresentaram FAN. Dez pacientes excluídos por estarem em FA na admissão hospitalar. Houve diferenças entre os grupos 1 e 2, respectivamente, no tempo de permanência em UTI (11,1±10,5 dias vs. 4,9±7,5 dias; p=0,004), necessidade de ventilação invasiva (82,9% e 32,7%; p<0,001) e mortalidade hospitalar (75,9% vs. 32,1%; p<0,001). No modelo de Cox, idade > 71 anos (hazard ratio [HR]=6,8; p<0,001), leucometria ≤ 7.720 cels.μL-1 (HR=6,6; p<0,001), natremia ≤ 137 mEq.L-1 (HR=5,0; p=0,001), escore SAPS3 > 55 (HR=5,6; p=0,002) e desorientação (HR=2,5; p=0,04) foram preditores independentes de FAN. Conclusões FAN é uma arritmia comum em idosos hospitalizados com pneumonia por COVID-19. Parâmetros clínicos e laboratoriais avaliados na admissão são preditores de FAN durante internação. (FAN COVID19. COVID19 COVID 19. 19 Analisar observacional retrospectivo casocontrole. casocontrole caso controle. controle caso-controle 6 COVID-1 º 2020 `t t quiquadrado. quiquadrado qui quadrado. quadrado qui-quadrado Considerouse Considerou se 005 0 05 0,0 significativo 66 COVID19, 19, 20 30,1% 301 30 (30,1% incluídos 14,4% 144 14 4 (14,4% grupo 1. . 1) 16 respectivamente 11,1±10,5 111105 11 10 5 (11,1±10, vs 4975 9 7 4,9±7, p=0,004, p0004 p=0,004 , 004 p=0,004) 82,9% 829 82 (82,9 32,7% 327 32 p<0,001 p0001 001 75,9% 759 75 (75,9 32,1% 321 p<0,001. hazard HR=6,8 HR68 HR =6,8 8 [HR]=6,8 p<0,001, 7720 720 7.72 cels.μL1 celsμL1 celsμL cels.μL cels μL cels.μL- HR=6,6 HR66 (HR=6,6 13 mEq.L1 mEqL1 mEqL mEq.L mEq L mEq.L- HR=5,0 HR50 (HR=5,0 p=0,001, p=0,001 p=0,001) SAPS HR=5,6 HR56 (HR=5,6 p=0,002 p0002 002 HR=2,5 HR25 (HR=2,5 p=0,04 p004 04 internação COVID1 COVID- 202 00 0, 30,1 3 (30,1 14,4 (14,4 11,1±10, 11110 (11,1±10 497 4,9±7 p000 p=0,00 82,9 (82, 32,7 p<0,00 75,9 (75, 32,1 HR=6, HR6 68 =6, [HR]=6, 772 72 7.7 μL1 (HR=6, L1 HR=5, HR5 (HR=5, HR=2, HR2 (HR=2, p=0,0 p00 30, (30, 14, (14, 11,1±10 1111 (11,1±1 49 4,9± 82, (82 32, p<0,0 75, (75 HR=6 =6 [HR]=6 77 7. (HR=6 HR=5 (HR=5 HR=2 (HR=2 p=0, p0 (30 (14 11,1±1 111 (11,1± 4,9 (8 p<0, (7 HR= = [HR]= (HR= p=0 (3 (1 11,1± (11,1 4, ( p<0 [HR] (HR p= 11,1 (11, p< [HR 11, (11

SUMMARY OBJECTIVE: COVID-19 has brought emerging public health emergency and new challenges. It configures a complex panorama that has been requiring a set of coordinated actions and has innovation as one of its pillars. In particular, the use of digital tools plays an important role. In this context, this study presents a screening algorithm that uses a machine learning model to assess the probability of a diagnosis of COVID-19 based on clinical data. METHODS: This algorithm was made available for free on an online platform. The project was developed in three phases. First, an machine learning risk model was developed. Second, a system was developed that would allow the user to enter patient data. Finally, this platform was used in teleconsultations carried out during the pandemic period. RESULTS: The number of accesses during the period was 4,722. A total of 126 assistances were carried out from March 23, 2020, to June 16, 2020, and 107 satisfaction survey returns were received. The response rate to the questionnaires was 84.92%, and the ratings obtained regarding the satisfaction level were higher than 4.8 (on a 0–5 scale). The Net Promoter Score was 94.4. CONCLUSION: To the best of our knowledge, this is the first online application of its kind that presents a probabilistic assessment of COVID-19 using machine learning models exclusively based on the symptoms and clinical characteristics of users. The level of satisfaction was high. The integration of machine learning tools in telemedicine practice has great potential. OBJECTIVE COVID19 COVID 19 COVID-1 challenges pillars particular role context data METHODS phases First Second Finally RESULTS 4722 4 722 4,722 12 23 2020 16 10 received 8492 84 92 84.92% 48 8 4. 05 0 5 0– scale. scale . scale) 944 94 94.4 CONCLUSION knowledge users high potential COVID1 1 COVID- 472 72 4,72 2 202 849 9 84.92 94. 47 7 4,7 20 84.9 4, 84.

Resumo Objetivo: Definir os critérios diagnósticos da COVID-19 na tomografia computadorizada (TC), estudar a concordância entre a TC e o PCR e determinar a associação da extensão do envolvimento parenquimatoso e ventilação mecânica com os achados tomográficos e características clínicas da amostra. Materiais e Métodos: Estudo de 155 pacientes com COVID-19 atendidos entre março e maio de 2020. Tentamos determinar se os achados da TC se correlacionavam com a idade e variáveis clínicas, bem como se a necessidade de ventilação mecânica se correlacionava com a extensão do envolvimento pulmonar. Resultados: A faixa etária dos pacientes com COVID-19 (54,8 anos) foi maior do que a dos pacientes sem a doença (45,5 anos) (p = 0,031). Opacidades em vidro fosco foram as alterações mais frequentes (88,6%; p = 0,0001). Bandas parenquimatosas (p = 0,013), ectasia brônquica (p = 0,046) e consolidações peribroncovasculares (p = 0,012) foram mais frequentes nos pacientes que necessitaram de ventilação mecânica. Pacientes com comorbidades apresentaram envolvimento parenquimatoso mais extenso (p = 0,023). A TC apresentou sensibilidade de 84,3%, especificidade de 36,7% e acurácia de 73,5% (p = 0,012). Conclusão: Os padrões de TC são úteis para o diagnóstico de COVID-19 e avaliação dos critérios de gravidade da doença. Pacientes com comorbidades estão associados a condições clínicas mais graves.

Abstract Objective: To define diagnostic criteria for coronavirus disease 2019 (COVID-19) on computed tomography (CT); to study the correlation between CT and polymerase chain reaction (PCR) testing for infection with severe acute respiratory syndrome coronavirus 2; and to determine whether the extent of parenchymal involvement and the need for mechanical ventilation are associated with the CT findings and clinical characteristics of patients with COVID-19. Materials and Methods: This was a retrospective study of 155 patients with COVID-19 treated between March and May 2020. We attempted to determine whether the CT findings correlated with age and clinical variables, as well as whether the need for mechanical ventilation correlated with the extent of the pulmonary involvement. Results: On average, the patients with COVID-19 were older than were those without (mean age, 54.8 years vs. 45.5 years; p = 0.031). The most common CT finding (seen in 88.6%) was ground-glass opacity, which correlated significantly with a diagnosis of COVID-19 (p = 0.0001). The CT findings that correlated most strongly with the need for mechanical ventilation were parenchymal bands (p = 0.013), bronchial ectasia (p = 0.046), and peribronchovascular consolidations (p = 0.012). The presence of one or more comorbidities correlated significantly with more extensive parenchymal involvement (p = 0.023). For the diagnosis of COVID-19, CT had a sensitivity of 84.3%, a specificity of 36.7%, and an accuracy of 73.5% (p = 0.012 vs. PCR). Conclusion: The patterns of CT findings are useful for the diagnosis of COVID-19 and the evaluation of disease severity criteria. The presence of any comorbidity is associated with greater severity of COVID-19.

Abstract Background: Telecardiology may be a useful support in diagnosis and management of chest pain. Objective: Evaluate the application of telecardiology to support the differential diagnosis of chest pain in patients admitted to Emergency Care Units. Method: Observational, retrospective and documental study of 5,816 patients admitted with supposedly cardiological chest pain in twenty two Emergency Care Units in the state of Rio de Janeiro. Data were tabulated and analyzed by Excel® software, using simple descriptive statistics, from the database of the Cardiology Consultancy Nucleus. Results: Diagnostic disagreement was found in 1,593 (27.39%) cases. Of these, 1,477 (92.72%) were diagnosed locally as non-ST-elevation myocardial infarction (non-STEMI), 74 (4.64%) as acute myocardial infarction with ST-segment elevation (STEMI), 40 (2.52%) as acute pulmonary edema (APE) and 2 (0.12%) as tachyarrhythmia. Intensive care referral was requested to 100% of these patients. After telecardiology, the diagnoses were: 385 (24.17%) unstable angina, 289 (18.14%) congestive heart failure, 212 (13.31%) APE, 174 (10.92%) STEMI, 152 (9.54%) hypertensive emergency, 113 (7.09%) acute chronic renal failure, 89 (5.59%) non-STEMI, 89 (5.59%) pneumonia, 39 (2.45%) sepsis, 26 (1.63 %) myopericarditis, 20 (1.26%) tachyarrhythmia and 5 (0.31%) orovalvar disease. The outcome after telecardiology was 1,178 discharges (73.94%), 338 (21.21%) referrals, 62 (3.90%) deaths and 15 (0.95%) unknown. Conclusion: Telecardiology was effective in chest pain diagnosis and management, optimizing hospital admission in the public health system.

Resumo Objetivo: Avaliar, em crianças pré-púberes obesas, a distribuição da gordura no abdome por meio da ultrassonografia e sua possível correlação com as alterações metabólicas decorrentes da obesidade. Materiais e Métodos: Estudo transversal em crianças pré-púberes, sendo 77 obesas (33 meninas e 44 meninos) com média de idade de 7,31 anos e 31 eutróficas (17 meninas e 14 meninos) com média de idade de 7,32 anos. Em todas as crianças foram medidas a espessura da parede abdominal (EPA) e a espessura da gordura intra-abdominal (EIA), pela ultrassonografia. Para a avaliação das alterações metabólicas associadas, foi realizada dosagem sérica de glicemia, HDL-colesterol, triglicerídeos e insulina. Resultados: Observou-se que as crianças obesas apresentaram aumento da gordura abdominal, com predomínio da EPA e sem diferença significativa da EIA e a EPA em relação ao gênero. Foi encontrada associação direta estatisticamente significante entre o índice homeostatic model assessment for insulin resistance (HOMA-IR) e EPA e EIA. Conclusão: A EPA em pré-púberes obesos, medida pela ultrassonografia, demonstrou ter maior relação com o HOMA-IR, determinante de resistência insulínica, em relação ao metabolismo lipídico e à glicemia.

Abstract Objective: To evaluate, using ultrasound, the distribution of abdominal fat in obese prepubertal children, as well as its possible correlation with metabolic changes due to obesity. Materials and Methods: This was a cross-sectional study of prepubescent children: 77 obese children (33 girls and 44 boys), with a mean age of 7.31 years; and 31 normal-weight children (17 girls and 14 boys), with a mean age of 7.32 years. In all of the children, abdominal wall thickness (AWT) and abdominal fat thickness (AFT) were measured by ultrasound. For the evaluation of the associated metabolic alterations, serum levels of glycemia, HDL cholesterol, triglycerides, and insulin were determined. Results: The obese children presented with greater abdominal fat, predominantly greater AWT, without a significant gender-related difference in AWT or AFT. The homeostasis model assessment of insulin resistance (HOMA-IR) showed a significant direct correlation with AWT and AFT. Conclusion: In obese prepubertal children, the AWT, as measured by ultrasound, was shown to be more closely related to the HOMA-IR than to the lipid metabolism or glycemia.

OBJETIVO: Investigar se a sucção ao seio materno influencia as velocidades do fluxo sanguíneo cerebral. MATERIAIS E MÉTODOS: Foram incluídos 256 neonatos saudáveis e a termo, sendo 50,8% do sexo feminino, todos com peso adequado para a idade gestacional. O índice de pulsatilidade, o índice de resistência e a velocidade média foram medidos durante ou após a amamentação na artéria cerebral anterior, artéria cerebral média esquerda e artéria cerebral média direita, entre 10 e 48 horas de vida pós-natal. Os dados foram analisados por meio de um teste t para amostras pareadas, e teste de Brieger por análise de variância e análises de regressão linear, sendo p < 0,01 aceito como significativo. RESULTADOS: Os valores do índice de resistência diminuíram à medida que a velocidade média aumentou significativamente durante a sucção ao seio materno. Os valores do índice de pulsatilidade diminuíram tanto quanto o índice de resistência, mas sem significância estatística na artéria cerebral média direita. CONCLUSÃO: A amamentação influencia as velocidades do fluxo sanguíneo cerebral.

OBJECTIVE: To investigate whether breastfeeding influence the cerebral blood-flow velocity. MATERIALS AND METHODS: The present study included 256 healthy term neonates, all of them with appropriate weight for gestational age, 50.8% being female. Pulsatility index, resistance index and mean velocity were measured during breastfeeding or resting in the anterior cerebral artery, in the left middle cerebral artery, and in the right middle cerebral artery of the neonates between their first 10 and 48 hours of life. The data were analyzed by means of a paired t-test, Brieger's f-test for analysis of variance and linear regression, with p < 0.01 being accepted as statistically significant. RESULTS: Mean resistance index decreased as the mean velocity increased significantly during breastfeeding. Pulsatility index values decreased as much as the resistance index, but in the right middle cerebral artery it was not statistically significant. CONCLUSION: Breastfeeding influences the cerebral blood flow velocities.

OBJETIVO: Propor um método reprodutível, de fácil utilização e de baixo custo para a digitalização de filmes radiográficos de todos os tamanhos padrões, concentrando nossos esforços em filmes radiográficos de tórax. MATERIAIS E MÉTODOS: O objetivo de baixo custo ditou o uso de um escâner A4 com adaptador de transparência, bem como um software de costura de imagens otimizado, que tira proveito da geometria do escâner e área de captura constante, bem como o conhecimento das dimensões dos filmes radiográficos padrões. RESULTADOS: O resultado final do método proposto é uma imagem de alta resolução com bom contraste e sem artefatos de costura perceptíveis. CONCLUSÃO: O método de digitalização proposto usando um escâner A4 possibilita reprodutibilidade, excelente qualidade de imagem e alto grau de certeza na identificação de lesões.

OBJECTIVE: To propose a reproducible, user friendly and low cost method for digitization of radiographic films of all the standard sizes, focusing efforts on chest X-ray films. MATERIALS AND METHODS: The focus on low cost have dictated the use of an A4 scanner with transparency adapter, as well as an optimized image stitching software that takes advantage of the scanner geometry and constant capture area, besides the knowledge of the standard X-ray film sizes. RESULTS: The end result of the proposed method is a high resolution image with good contrast and no perceptible stitching artifacts. CONCLUSION: The proposed digitization method with an A4 scanner allows reproducibility, excellent image quality and high degree of certainty in the identification of lesions.

OBJECTIVES: A low ratio of omega-6/omega-3 polyunsaturated fatty acids is associated with healthy bone properties. However, fatty diets can induce obesity. Our objective was to evaluate intra-abdominal adiposity, insulin, and bone growth in rats fed a high-fat diet containing low ratios of omega-6/omega-3 provided in canola oil. METHODS: After weaning, rats were grouped and fed either a control diet (7S), a high-fat diet containing soybean oil (19S) or a high-fat diet of canola oil (19C) until they were 60 days old. Differences were considered to be significant if p<0.05. RESULTS: After 60 days, the 19S and 19C groups showed more energy intake, body density growth and intraabdominal fat mass. However, the 19S group had a higher area (200%) and a lower number (44%) of adipocytes, while the 7S and 19C groups did not differ. The serum concentrations of glucose and insulin and the insulin resistance index were significantly increased in the 19C group (15%, 56%, and 78%, respectively) compared to the 7S group. Bone measurements of the 19S and 19C groups showed a higher femur mass (25%) and a higher lumbar vertebrae mass (11%) and length (5%). Computed tomography analysis revealed more radiodensity in the proximal femoral epiphysis and lumbar vertebrae of 19C group compared to the 7S and 19S groups. CONCLUSIONS: Our results suggest that the amount and source of fat used in the diet after weaning increase body growth and fat depots and affect insulin resistance and, consequently, bone health.

A educação infantil é importante para o desenvolvimento da criança com necessidades especiais. Nesse processo educacional, o professor e sua percepção de educação inclusiva são fatores primordiais. Este trabalho objetivou analisar a percepção de professores de educação infantil, que quanto à prática educativa atual, diferem em relação à presença de alunos com deficiências em seus ambientes de trabalho, sobre a educação da criança com deficiência na faixa etária de 3 a 6 anos. Foram sujeitos da pesquisa 12 professores de educação infantil divididos eqüitativamente em três grupos: de escolas especiais; de escolas comuns que trabalham com crianças com deficiências inseridas em suas classes e de escolas comuns que não possuem em suas classes crianças com deficiências. A coleta de dados foi realizada através de entrevistas semi-estruturadas, gravadas em fita cassete. Foi realizada análise de conteúdo e os dados mostraram que os professores vêem como a principal contribuição do processo de inclusão a socialização da criança com deficiências, restringindo-o, porém, a crianças com possibilidades de independência. Quanto à aprendizagem, acreditam que a criança com deficiência mental é a que encontra maiores dificuldades, contrariamente à com deficiência física. Ressaltam problemas com o espaço físico, recursos materiais e humanos e relativos à formação do professor. Pôde se concluir que é preciso possibilitar aos professores uma formação que abranja conhecimentos sobre as diferentes deficiências e as necessidades educacionais relativas a estas, propiciar a adequação do espaço físico e dos recursos materiais, além de assistência técnica específica.

Early childhood education is important for the development of children with special needs. The teacher and his/her perception of inclusive education are essential factors throughout such educational processes. The present study aimed to analyze early childhood teacher's perception of the education of children with disabilities aged three and six years. Their perception of current educational practices is different due to the presence of special needs children in their working environment. Twelve childhood education teachers participated in this study and were equally divided into three groups: those from special schools; those from ordinary schools, who work with children with disabilities and those from ordinary schools who don't have children with disabilities in the classroom. The data were collected using tape recorded semi-structured interviews. Content analysis was performed. The data indicated that the teachers see the disabled children's socialization as the main contribution of the inclusive process, however, they deemed that inclusion should be restricted to children with possibilities of independence. As to the learning process, they expressed that children with intellectual disabilities had more difficulty than the ones with physical disability. Problems regarding physical space, material and human resources as well as teacher education were pointed out. It was concluded that the teachers need preparation not only regarding the understanding of various disabilities and the educational needs related to them but also about adequate physical space, material resources and specific technical assistance.

OBJETIVO: Descrever e comparar os métodos de imagem e os aspectos clínicos em quatro recém-natos a termo diagnosticados como trombose venosa cerebral, sem dano encefálico, adscritos a uma unidade de terapia intensiva neonatal. MATERIAIS E MÉTODOS: Revisão em 10 anos com quatro casos diagnosticados como trombose venosa cerebral por meio de ultrassonografia transfontanela com Doppler e confirmados por ressonância magnética/angiorressonância, correlacionados aos aspectos clínicos e evolução neurológica. RESULTADOS: A ultrassonografia foi normal em 75% dos casos e a ressonância magnética, em 100%. No caso alterado, a dilatação venosa foi identificada. O Doppler e a angiorressonância estavam alterados em 100% dos casos. Dos aspectos clínicos, a hipóxia (100%) e a convulsão precoce (100%) predominaram, com potencial evocado alterado em 50% dos casos. Na avaliação do neurodesenvolvimento, todas as áreas estiveram dentro da normalidade até a última avaliação. CONCLUSÃO: A ultrassonografia associada ao Doppler é capaz de identificar as alterações da trombose venosa cerebral, devendo ser complementada com a ressonância magnética, que é o padrão ouro de diagnóstico.

OBJECTIVE: To describe and compare imaging methods and clinical findings of cerebral venous thrombosis in four full-term neonates without brain damage, admitted to a neonatal intensive care unit. MATERIALS AND METHODS: Ten-year review of four cases diagnosed with cerebral venous thrombosis by transfontanellar ultrasonography associated with Doppler fluxometry and confirmed by magnetic resonance imaging/magnetic resonance angiography in correlation with clinical findings and neurological progression. RESULTS: Ultrasonography presented normal results in 75% of cases and magnetic resonance imaging in 100%. Doppler fluxometry and magnetic resonance angiography were abnormal in 100% of cases. Hypoxia (100%) and early seizures (100%) were predominant among clinical findings with evoked potential changes in 50% of cases. In the assessment of the neurodevelopment all the areas remained within normality parameters up to the conclusion of the present study. CONCLUSION: Ultrasonography in association with Doppler can identify changes related to cerebral venous thrombosis and should be complemented with magnetic resonance imaging that is the gold standard for diagnosis in these cases.

Estudo retrospectivo de dois casos de hemorragia craniana de localização atípica em 777 recém-natos internados na unidade de terapia intensiva neonatal da Casa de Saúde São José, Rio de Janeiro, RJ. Foram avaliados os aspectos clínicos e o diagnóstico por métodos de imagem. Verificamos que a ultrassonografia foi diagnóstica nos dois casos quando comparada com a ressonância magnética. Em relação à etiologia, esta foi multifatorial, e a manifestação clínica silenciosa independente da localização. Até o presente momento, a avaliação neurológica tem tido curso satisfatório, embora os pacientes ainda tenham baixa idade para a avaliação neurológica definitiva.

Retrospective study of two cases of atypically localized cerebral hemorrhage among 777 newborns admitted to the neonatal intensive care unit at Casa de Saúde São José, Rio de Janeiro, RJ, Brazil. Clinical findings and imaging diagnoses were evaluated. The diagnostic effectiveness of ultrasonography was established by correlation with magnetic resonance imaging findings. Multifactorial etiology was observed, besides silent clinical presentation independently from localization. So far the neurological evaluation has satisfactorily progressed although the patients are still too young to allow a definite neurological evaluation.