Resumo Quais ataques cibernéticos às infraestruturas críticas sofreu a Ucrânia entre fevereiro de 2022 e fevereiro de 2023 durante a guerra russo-ucraniana? Nos últimos meses, a Ucrânia vem sofrendo uma grande ofensiva de ataques cibernéticos às suas infraestruturas críticas. Assim, o objetivo deste trabalho é analisar quais ataques cibernéticos às infraestruturas críticas sofreu a Ucrânia dentro do recorte selecionado. Para isso, foi realizada uma pesquisa de método misto, que foi operacionalizada por meio de estatística descritiva, análise documental e revisão sistemática da literatura. Assim, a partir dos dados analisados do CyberPeace Institute, o setor mais atingido foi o de administração pública (66), enquanto a categoria de ataques mais utilizada foi de disrupção (139). Em seguida, avaliamos os tipos de ataques cibernéticos, sendo o mais utilizado o de tipo «DDoS» (135). Já na categoria de atores, a categoria «coletiva» (124), com destaque para o People’s CyberArmy (48), foi a de maior ocorrência. Em suma, concluímos que os ataques às infraestruturas críticas constituem uma questão de defesa nacional, sendo necessário revisar a legislação relacionada a esse tema e garantir que os órgãos responsáveis estejam preparados para enfrentar problemas futuros.

Abstract What cyberattacks did Ukraine’s critical infrastructure experience between February 2022 and February 2023 during the Russo-Ukrainian war? In recent months, Ukraine has experienced a significant increase in cyberattacks on its critical infrastructure. Therefore, the purpose of this study is to analyze the cyberattacks suffered by Ukraine’s critical infrastructure within the selected cutout. A mixed method research approach was used, operationalized through descriptive statistics, documentary analysis, and a systematic literature review. Based on the analyzed data from the CyberPeace Institute, the sector most affected was public administration (66), with the Disruption attack category being the most utilized (139). The types of cyberattacks were also evaluated, with the DDoS type being the most common (135). The collective (124), especially the People’s CyberArmy (48), was the most common in the actor category. In conclusion, we can say that attacks on critical infrastructure are a matter of national defense, which requires a revision of legislation on this issue and ensuring that the responsible bodies are prepared for future challenges.

RESUMO O objetivo do artigo é tratar da relação entre escatologia cristã e práxis, focando na dimensão escatológica do presente. Historicamente, a escatologia clássica se ocupou do futuro absoluto e ignorou o presente histórico. A vida presente era relegada à condição de provação. A escatologia era vista como uma futurologia cristã. As teologias da práxis, na segunda metade do século XX, descobriram a dimensão escatológica do presente. A escatologia passa a ser vista como a disciplina teológica que trata das realidades últimas a partir das penúltimas. O presente histórico conquista uma visibilidade escatológica. Ocupando-se do presente, a escatologia desenvolve um aspecto crítico e libertador. A metodologia do artigo é bibliográfica em sintonia com teólogos da práxis (teologia política, da libertação e da esperança) e com os comentaristas da dimensão prática da teologia. O percurso metodológico reflete sobre a dimensão escatológica da atividade de Jesus, a densidade escatológica do presente histórico, o aspecto escatológico das teologias da práxis e a relação entre escatologia e ética. Historicamente provação XX penúltimas Ocupandose Ocupando libertador teologia política esperança Jesus ética

ABSTRACT This article deals with the relationship between Christian eschatology and praxis, focusing on the eschatological dimension of the present. Historically, classical eschatology was concerned with the absolute future and ignored the historical present. Present life was relegated to the condition of probation. Eschatology was seen as Christian futurology. In the second half of the 20th century, the theologies of praxis discovered the eschatological dimension of the present. Eschatology comes to be seen as the theological discipline that concerns ultimate realities drawn from penultimate realities. The historical present gains eschatological visibility. By dealing with the present, eschatology develops a critical and liberating aspect. The bibliographical methodology employed in the article is in line with the theologians of praxis (political theology, liberation theology, and the theology of hope) as well as with commentators on the practical dimension of theology. The methodological approach reflects on the eschatological dimension of Jesus’ activity, the eschatological density of the historical present, the eschatological aspect of the theologies of praxis, and the relationship between eschatology and ethics. Historically probation futurology th century visibility political hope Jesus activity ethics

ABSTRACT BACKGROUND: Specific types of violence such as intimate partner sexual violence and intimate partner homicide occur more frequently in rural areas. OBJECTIVE: This study aimed to systematically review the literature on the knowledge and attitudes of rural healthcare providers regarding cases of domestic violence against women. DESIGN AND SETTING: Systematic review developed at Universidade Federal de Uberlândia. METHODS: We conducted an electronic search of six databases, which only included observational studies, regardless of the year, language, or country of publication, except for studies that used secondary data and were exclusively qualitative. Two reviewers performed the selection, data extraction, and risk of bias assessment using a specific Joanna Briggs Institute tool. RESULTS: Six studies met the inclusion criteria. All the studies had a low risk of bias. Approximately 38% of these professionals identified injuries caused by violence in patients. When asked about knowing the correct attitude to take in cases of confirmed violence, between 12% and 64% of rural healthcare providers answered positively; most of them would refer to specialized institutions and promote victim empowerment and counseling. The number of professionals with an educational background in the field ranged from 16% to 98%. CONCLUSIONS: The evident disparity across studies shows that some professionals have suboptimal knowledge and require training to adopt the correct attitude when identifying female victims of domestic violence in clinical practice. SYSTEMATIC REVIEW REGISTRATION: This systematic review was registered in the Open Science Framework Database under the registration http://doi.org/10.17605/OSF.IO/B7Q6S. BACKGROUND areas OBJECTIVE women SETTING Uberlândia METHODS databases year language publication qualitative selection extraction tool RESULTS criteria 38 patients 12 64 positively counseling 16 98 98% CONCLUSIONS practice REGISTRATION http//doi.org/10.17605/OSF.IO/B7Q6S. httpdoiorg1017605OSFIOB7Q6S httpdoiorgOSFIOBQS http //doi.org/10.17605/OSF.IO/B7Q6S. doi org 10 17605 OSF IO B7Q6S B Q S http://doi.org/10.17605/OSF.IO/B7Q6S 3 1 6 9 http//doi.org/10.17605/OSF.IO/B7Q6S httpdoiorg OSFIOB doiorg1017605OSFIOB7Q6S doiorgOSFIOBQS //doi.org/10.17605/OSF.IO/B7Q6S 1760 BQS doiorg 176 17

In multiparty presidential regimes, the head of the Executive manages a heterogeneous political base through a series of instruments. Among these tools, the use of patronage in appointments for governmental positions and the deployment of pork barrel to please congressional representatives have been highlighted by the literature as the glue that holds together multiparty coalitions. However, current studies neglect the role of politicians as active actors in multiparty presidential regimes in channeling resources to their constituencies and parties when holding a cabinet position. This paper contributes to the literature by merging these two tools of coalition maintenance. We analyze a complimentary strategy that benefits party leaders in the coalition by studying the relation of top-level cabinet appointments and grant transfers to subnational governments. Using data from Brazil, a paradigmatic case of multiparty presidential regime, we intend to answer the following question: Are ministries in Brazil being used to please ministers’ constituency and party allies? Using social networking analysis and econometrics for the period between 2011 and 2014, we provide evidence that ministers use their position to transfer funding to districts governed by fellow party members and not to their own political strongholds following a partisan pattern instead of a personal one. instruments coalitions However maintenance toplevel top level governments regime question allies 201 2014 one 20 2

Resumo: A inteligência artificial pode detectar manifestações de ideação suicida em textos. Estudos demonstram que os modelos baseados em BERT alcançam melhor desempenho em testes de classificação de texto. Os grandes modelos de linguagem (LLMs - large language models) respondem a consultas de texto livre sem serem especificamente treinados. Este trabalho tem como objetivo comparar o desempenho de três variações de modelos BERT e LLMs (Google Bard, Microsoft Bing/GPT-4 e OpenAI ChatGPT-3.5) para identificar ideação suicida a partir de textos não clínicos escritos em Português brasileiro. Foi usado um conjunto de dados rotulado por psicólogos composto por 2.691 sentenças sem ideação suicida e 1.097 com ideação suicida, das quais 100 sentenças foram selecionadas para o processo de teste. Técnicas de pré-processamento de dados, otimização de hiperparâmetros e validação cruzada holdout foram aplicadas para treinar e testar os modelos BERT. Ao avaliar LLMs, usamos comandos de disparo zero. Cada frase de teste foi rotulada com base na presença de ideação suicida, de acordo com a resposta do chatbot. O Bing/GPT-4 alcançou o melhor desempenho, demonstrando 98% em todas as métricas. Os modelos BERT ajustados superaram os outros LLMs: o BERTimbau-Large teve o melhor desempenho, demonstrando 96% de acurácia, seguido pelo BERTimbau-Base com 94% e pelo BERT-Multilingual com 87%. O Bard teve o pior desempenho, apontando 62% de acurácia, enquanto o ChatGPT-3.5 alcançou 81%. O alto recall dos modelos indica uma baixa taxa de falsos negativos de pacientes em risco, o que é crucial para evitar intervenções profissionais desnecessárias. No entanto, apesar de seu potencial no suporte à detecção de ideação suicida, esses modelos não foram validados em um ambiente clínico de monitoramento de pacientes. Portanto, recomenda-se cautela ao empregar esses modelos como ferramentas para auxiliar profissionais de saúde na detecção de ideação suicida.

Abstract: Artificial intelligence can detect suicidal ideation manifestations in texts. Studies demonstrate that BERT-based models achieve better performance in text classification problems. Large language models (LLMs) answer free-text queries without being specifically trained. This work aims to compare the performance of three variations of BERT models and LLMs (Google Bard, Microsoft Bing/GPT-4, and OpenAI ChatGPT-3.5) for identifying suicidal ideation from nonclinical texts written in Brazilian Portuguese. A dataset labeled by psychologists consisted of 2,691 sentences without suicidal ideation and 1,097 with suicidal ideation, of which 100 sentences were selected for testing. We applied data preprocessing techniques, hyperparameter optimization, and hold-out cross-validation for training and testing BERT models. When evaluating LLMs, we used zero-shot prompting engineering. Each test sentence was labeled if it contained suicidal ideation, according to the chatbot’s response. Bing/GPT-4 achieved the best performance, with 98% across all metrics. Fine-tuned BERT models outperformed the other LLMs: BERTimbau-Large performed the best with a 96% accuracy, followed by BERTimbau-Base with 94%, and BERT-Multilingual with 87%. Bard performed the worst with 62% accuracy, whereas ChatGPT-3.5 achieved 81%. The high recall capacity of the models suggests a low misclassification rate of at-risk patients, which is crucial to prevent missed interventions by professionals. However, despite their potential in supporting suicidal ideation detection, these models have not been validated in a patient monitoring clinical setting. Therefore, caution is advised when using the evaluated models as tools to assist healthcare professionals in detecting suicidal ideation.

Resumen: La inteligencia artificial puede detectar manifestaciones de ideación suicida en textos. Los estudios demuestran que los modelos basados en BERT logran un mejor rendimiento en las pruebas de clasificación de textos. Los grandes modelos de lenguaje (LLMs, large language models) responden a consultas de texto libre sin estar específicamente capacitados. Este trabajo tiene como objetivo comparar el rendimiento de tres variaciones de modelos BERT y LLMs (Google Bard, Microsoft Bing/GPT-4 y OpenAI ChatGPT-3.5) para identificar ideación suicida con base en textos no clínicos escritos en Portugués brasileño. Se utilizó un conjunto de datos etiquetados por psicólogos que constaba de 2.691 sentencias sin ideación suicida y 1.097 con ideación suicida, de las cuales se seleccionaron 100 sentencias para el proceso de prueba. Técnicas de preprocesamiento de datos, optimización de hiperparámetros y validación cruzada holdout se aplicaron para entrenar y probar modelos BERT. Al evaluar los LLM, utilizamos comandos de disparo cero. Cada frase de prueba fue etiquetada con base en la presencia de ideación suicida, según la respuesta del chatbot. Bing/GPT-4 logró el mejor rendimiento, demostrando un 98% en todas las métricas. Los modelos BERT ajustados superaron a los otros LLM: BERTimbau-Large obtuvo el mejor rendimiento, demostrando un 96% de accuracy, seguido de BERTimbau-Base con un 94% y de BERT-Multilingual con un 87%. Bard tuvo el peor rendimiento, logrando un 62% de accuracy, mientras que ChatGPT-3.5 logró un 81%. El alto recall de los modelos indica una baja tasa de falsos negativos de pacientes en riesgo, lo cual es crucial para evitar intervenciones profesionales innecesarias. Sin embargo, a pesar de su potencial para respaldar la detección de ideación suicida, estos modelos no se han validado en un entorno clínico de seguimiento de pacientes. Por lo tanto, se recomienda precaución al emplear estos modelos como herramientas para ayudar a los profesionales de la salud a detectar ideación suicida.

Resumo Encontrar formas de reaproveitar resíduos é uma alternativa não só para reduzir sua presença em ambientes urbanos e naturais, mas também para reduzir custos e consumo de matérias primas pelas indústrias. O objetivo deste trabalho é avaliar as propriedades de concretos fabricados através da substituição de agregados graúdos e miúdos convencionais por resíduo de mármore. Foram realizadas análises de morfologia, granulometria, massa específica e da fase cristalina dos agregados. A composição dos constituintes, em massa, foi 1:1,2:3 de cimento Portland CPIII-32 RS, agregados miúdos e agregados graúdos, respectivamente, com adição de 0,4 de água, moldados e curados em água. Foram confeccionadas cerca de 25 amostras de concreto, variando a quantidade de agregado graúdo/fino na massa de cimento de acordo com as proporções de agregados de: A= 100% brita/ 100% areia, B= 100% RRO grosso/ 50% RRO fino + 50% areia, C= 50% RRO grosso + 50% cascalho/ 100% RRO fino, e D = 100% RRO grosso/100% RRO fino. As amostras cilíndricas medindo ∅50 x 100 mm foram submetidas a testes de absorção de água e resistência à compressão, e os resultados obtidos foram comparados com algumas normas e com a literatura. A absorção de água foi inferior a 2,5% e a resistência à compressão ficou entre 27-33 MPa, valor próximo à resistência do cimento utilizado. A composição B apresenta os melhores resultados entre as demais, indicando a possibilidade de utilização do resíduo do mármore para produção de concretos para diversas finalidades como pavimentação de baixa carga, calçadas, blocos, entre outros. No entanto, para pisos intertravados, deve-se utilizar cimento de maior desempenho para atingir a resistência necessária. Esse tipo de concreto agrega valor ao resíduo e mitiga os impactos ambientais. naturais indústrias morfologia granulometria constituintes 11,23 1123 1 1,2 3 2 1:1,2: CPIII32 CPIII 32 CPIII-3 RS respectivamente 04 0 4 0, graúdofino graúdo brita areia 50 C cascalho grosso100 grosso/100 ∅5 10 literatura 5 2,5 2733 27 33 27-3 MPa utilizado demais carga calçadas blocos outros entanto intertravados devese deve se necessária ambientais 11 23 11,2 112 12 1, 1:1,2 CPIII3 CPIII- grosso10 grosso/10 ∅ 2, 273 27- 11, 1:1, grosso1 grosso/1 1:1 1:

Abstract Finding ways to reuse residue is an alternative not only to reduce its presence in urban and natural environments, but also to reduce costs and consumption of resources by industries. The objective of this paper is to evaluate the properties of concretes made by replacing conventional coarse and fine aggregates with marble residue. Morphological, granulometry, specific gravimetry and crystalline phase analyses were carried out in the aggregates. The composition of the constituents, by mass, was 1:1,2:3 of Portland cement CPIII-32 RS, fine aggregates, and coarse aggregate, respectively, with the addition of 0.4 of water, molded and cured in water. About 25 concrete samples were made, varying the amount of coarse/fine aggregate in the cement mass according to the aggregates proportions of: A= 100% gravel/ 100% sand, B= 100% coarse RRO/ 50% fine RRO + 50% sand, C= 50% coarse RRO + 50% gravel/ 100% fine RRO, and D = 100% coarse RRO/100% fine RRO. The cylindrical samples measuring ∅50 x 100 mm were subjected to water absorption and compressive strength tests, and the results were compared with standards and literature. The water absorption was smaller than 2.5% and the compressive strength values were between 27-33 MPa, close to the resistance of cement used. Composition B presented the best results among the others, indicating the possibility of using the residue from marble for production of concretes for various purposes such as low load paving, sidewalks, blocks, among others. However, for interlocking floors, higher performance cement should be used to achieve the required strength. This type of concrete adds value to the residue and mitigates environmental impacts. environments industries Morphological granulometry constituents 11,23 1123 1 1,2 3 2 1:1,2: CPIII32 CPIII 32 CPIII-3 RS respectively 04 0 4 0. coarsefine A gravel sand 50 C RRO100 RRO/100 ∅5 10 tests literature 5 2.5 2733 27 33 27-3 MPa others paving sidewalks blocks However floors impacts 11 23 11,2 112 12 1, 1:1,2 CPIII3 CPIII- RRO10 RRO/10 ∅ 2. 273 27- 11, 1:1, RRO1 RRO/1 1:1 1:

Abstract Associations between the WNT5A rs566926 variant and non-syndromic orofacial cleft (NSOC) have been reported in different populations. Objective This study aimed to investigate the role of the rs566926 single nucleotide polymorphism (SNP) in WNT5A and its interactions with SNPs in BMP4, FGFR1, GREM1, MMP2, and WNT3 in the occurrence of NSOC in a Brazilian population. Methodology A case-control genetic association study was carried out involving participants from four regions of Brazil, totaling 801 patients with non-syndromic cleft lip with or without cleft palate (NSCL±P), 273 patients with cleft palate only (NSCPO), and 881 health volunteers without any congenital condition (control). Applying TaqMan allelic discrimination assays, we evaluated WNT5A rs566926 in an ancestry-structured multiple logistic regression analysis, considering sex and genomic ancestry as covariates. Interactions between rs566926 and variants in genes involved in the WNT5A signaling pathway (BMP4, FGFR1, GREM1, MMP2, and WNT3) were also explored. Results WNT5A rs566926 was significantly associated with an increased risk of NSCL±P, particularly due to a strong association with non-syndromic cleft lip only (NSCLO), in which the C allele increased the risk by 32% (OR: 1.32, 95% CI: 1.04–1.67, p=0.01). According to the proportions of European and African genomic ancestry, the association of rs566926 reached significant levels only in patients with European ancestry. Multiple interactions were detected between WNT5A rs566926 and BMP4 rs2071047, GREM1 rs16969681 and rs16969862, and FGFR1 rs7829058. Conclusion The WNT5A rs566926 polymorphism was associated with NSCL±P, particularly in individuals with NSCLO and high European ancestry. Epistatic interactions involving WNT5A rs566926 and variants in BMP4, GREM1, and FGFR1 may contribute to the risk of NSCL±P in the Brazilian population. WNTA WNT rs rs56692 nonsyndromic non syndromic (NSOC populations SNP (SNP BMP FGFR GREM MMP2 MMP population casecontrol case control Brazil 80 NSCLP , NSCL P (NSCL±P) 27 NSCPO, NSCPO (NSCPO) 88 control. . (control) assays ancestrystructured structured analysis covariates (BMP4 explored NSCLO, (NSCLO) 32 OR (OR 132 1 1.32 95 CI 104167 04 67 1.04–1.67 p=0.01. p001 p p=0.01 0 01 p=0.01) rs2071047 rs1696968 rs16969862 rs7829058 rs5669 8 (NSCL±P 2 (NSCPO (control (BMP (NSCLO 3 13 1.3 9 10416 6 1.04–1.6 p00 p=0.0 rs207104 rs169696 rs1696986 rs782905 rs566 1. 1041 1.04–1. p0 p=0. rs20710 rs16969 rs169698 rs78290 rs56 104 1.04–1 p=0 rs2071 rs1696 rs7829 rs5 10 1.04– p= rs207 rs169 rs782 1.04 rs20 rs16 rs78 1.0 rs2 rs1 rs7

ABSTRACT BACKGROUND: Adolescence is characterized by complex and dynamic changes, often involving experimentation, including the use of psychotropic substances. Although it is well-established that recreational psychotropic drugs are associated with suicide ideation in adults, evidence of this association in adolescents remains limited. OBJECTIVE: To investigate the relationship between suicide ideation and psychotropic recreational drug use among adolescents. DESIGN AND SETTING: Systematic review with meta-analysis developed at Universidade Federal de Uberlândia (UFU) and Universidade Estadual de Campinas (UNICAMP), Brazil. METHODS: A search across eight electronic databases for observational studies, without language or publication year restrictions, was conducted. The Joanna Briggs Institute tool was used to assess the risk of bias. Random-effects meta-analyses and odds ratios were used to measure the effects. RESULTS: The search yielded 19,732 studies, of which 78 were included in the qualitative synthesis and 32 in the meta-analysis. The findings indicated that suicidal ideation was 1.96 times more likely (95% confidence interval, CI = 1.47; 2.61) for adolescents who used some drug recurrently and 3.32 times more likely (95%CI = 1.86; 5.93) among those who abused drugs. Additionally, adolescents who used cannabis were 1.57 times more likely (95%CI = 1.34; 1.84) to experience suicide ideation compared with non-users, while cocaine users had 2.57 times higher odds (95%CI = 1.47; 4.50). CONCLUSIONS: Psychotropic recreational drug use is associated with suicidal ideation among adolescents regardless of current or previous use, abuse, or type of substance used. SYSTEMATIC REVIEW REGISTRATION: Registered in the PROSPERO database under the identification number CRD42021232360. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021232360. BACKGROUND changes experimentation substances wellestablished well established adults limited OBJECTIVE SETTING metaanalysis meta analysis UFU (UFU UNICAMP, UNICAMP , (UNICAMP) Brazil METHODS studies restrictions conducted bias Randomeffects Random effects metaanalyses analyses RESULTS 19732 19 732 19,73 7 3 metaanalysis. analysis. 196 1 96 1.9 95% 95 (95 interval 1.47 147 47 2.61 261 2 61 332 3.3 95%CI 95CI 1.86 186 86 5.93 593 5 93 Additionally 157 57 1.5 1.34 134 34 1.84 184 84 nonusers, nonusers non users, non-users 257 2.5 4.50. 450 4.50 . 4 50 4.50) CONCLUSIONS abuse REGISTRATION CRD42021232360 CRD https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD42021232360. httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD42021232360 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD https //www.crd.york.ac.uk/prospero/display_record.php ID=CRD42021232360. www crd york ac uk prospero display record php ID https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021232360 (UNICAMP 1973 73 19,7 9 1. 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ABSTRACT Congenital heart disease (CHD) affects eight to ten out of every 1,000 births, resulting in approximately 23,057 new cases in Brazil in 2022. About one in four children with CHD requires surgery or other procedures in the first year of life, and it is expected that approximately 81% of these children with CHD will survive until at least 35 years of age. Professionals choosing to specialize in CHD surgery face numerous challenges, not only related to mastering surgical techniques and the complexity of the diseases but also to the lack of recognition by medical societies as a separate subspecialty. Furthermore, families face difficulties when access to services capable of providing treatment for these children. To address these challenges, it is essential to have specialized hospitals, qualified professionals, updated technologies, sustainable industry, appropriate financing, quality assessment systems, and knowledge generation. The path to excellence involves specialization across all involved parties. As we reflect on the importance of Pediatric Cardiovascular Surgery and Congenital Heart Diseases establishing themselves as a subspecialty of Cardiovascular Surgery, it is essential to look beyond our borders to countries like the United States of America and United Kingdom, where this evolution is already a reality. This autonomy has led to significant advancements in research, education, and patient care outcomes, establishing a care model. By following this path in Brazil, we not only align our practice with the highest international standards but also demonstrate our maturity and the ability to meet the specific needs of patients with CHD and those with acquired childhood heart disease. (CHD 1000 1 000 1,00 births 23057 23 057 23,05 2022 life 81 3 age challenges Furthermore hospitals professionals technologies industry financing systems generation parties Kingdom reality research education outcomes model 100 00 1,0 2305 2 05 23,0 202 8 10 0 1, 230 23, 20

ABSTRACT The knowledge of the bat fauna from Minas Gerais, the largest state in southeastern Brazil, has greatly changed in recent years due to increased sampling and taxonomic revisions with reports of range extension and/or new species descriptions. The first annotated list of bats for the state dates to over 10 years ago. Our study aimed to update it by incorporating new localities sampled since then and by adding new species records to the list. We also conducted a comprehensive review of the literature and museum databases and analyzed 691 specimens collected in the state from all mesoregions and ecosystems deposited in collections. We documented the occurrence of 99 bat species from nine families, distributed in 181 municipalities, covering all mesoregions and biomes of the state. This is an increment of 30% in bat richness and of 241% in locality sites with bat records in Minas Gerais, when compared with the previous compilation. We report two previously unrecorded species for the state, the phylostomids Rhinophylla pumilio Peters, 1865 and Trinycteris nicefori (Sanborn, 1949). The mesoregions with the largest number of bat collection localities were “Metropolitana” (46), “Zona da Mata” (26), and “Norte de Minas” (21). The Atlantic Forest had the largest number of collection sites compared to the other biomes present in the state (102). There are a lot of sampling gaps in the state, and most of the conservation areas have not yet been sampled for bats. In face of that and based on the recent findings of several new species and records as a result of sampling and revisionary efforts, we suggest the implementation of rapid survey programs accompanied by taxonomic studies within the conservation units of Minas Gerais. Long-term monitoring programs, including bats, are also completely missing in the state. Gerais Brazil andor or descriptions 1 ago 69 collections 9 families 18 municipalities 30 241 compilation Peters 186 Sanborn, Sanborn (Sanborn 1949. 1949 . 1949) Metropolitana “Metropolitana 46, 46 , (46) Zona Mata 26, 26 (26) Norte 21. 21 (21) 102. 102 (102) efforts Longterm Long term 6 3 24 194 4 (46 2 (26 (21 (102 19 (4 (2 (10 ( (1

ABSTRACT Introduction: Heart transplantation is the gold standard for advanced heart failure treatment. This study examines the survival rates and risk factors for early mortality in adult heart transplant recipients at a Brazilian center. Methods: This retrospective cohort study involved 255 adult heart transplant patients from a single center in Brazil. Data were collected from medical records and databases including three defined periods (2012-2015, 2016-2019, and 2020-2022). Statistical analysis employed Kaplan-Meier survival curves, Cox proportional hazards analysis for 30-day mortality risk factors, and Log-rank tests. Results: The recipients were mostly male (74.9%), and the mean age was 46.6 years. Main causes of heart failure were idiopathic dilated cardiomyopathy (33.9%), Chagas cardiomyopathy (18%), and ischemic cardiomyopathy (14.3%). The study revealed an overall survival of 68.1% at one year, 58% at five years, and 40.8% at 10 years after heart transplantation. Survivalimproved significantly over time, combining the most recent periods (2016 to 2022) it was 73.2% in the first year and 63% in five years. The main risk factors for 30-day mortality were longer time on cardiopulmonary bypass, the initial period of transplants (2012 to 2015), older age of the donor, and nutritional status of the donor (overweight or obese). The main causes of death within 30 days post-transplant were infection and primary graft dysfunction. Conclusion: The survival analysis by period demonstrated that the increased surgical volume, coupled with the team’s experience and modifications to the immunosuppression protocol, contributed to the improved early and mid-term outcomes. Introduction treatment Methods 25 Brazil 20122015, 20122015 2012 2015, 2015 (2012-2015 20162019, 20162019 2016 2019, 2019 2016-2019 20202022. 20202022 2020 2022 . 2020-2022) KaplanMeier Kaplan Meier curves 30day day Logrank Log rank tests Results 74.9%, 749 74.9% , 74 9 (74.9%) 466 46 6 46. 33.9%, 339 33.9% 33 (33.9%) 18%, 18 18% (18%) 14.3%. 143 14.3% 14 3 (14.3%) 681 68 1 68.1 58 408 40 8 40.8 (201 732 73 2 73.2 63 bypass 2015) overweight obese. obese obese) posttransplant post dysfunction Conclusion volume teams team s protocol midterm mid term outcomes 2012201 201 (2012-201 2016201 2016-201 2020202 202 2020-2022 74.9 7 (74.9% 4 33.9 (33.9% (18% 14.3 (14.3% 68. 5 40. (20 73. 201220 20 (2012-20 201620 2016-20 202020 2020-202 74. (74.9 33. (33.9 (18 14. (14.3 (2 20122 (2012-2 20162 2016-2 20202 2020-20 (74. (33. (1 (14. ( (2012- 2016- 2020-2 (74 (33 (14 2020- (7 (3

Abstract Background Local anesthetic puncture is often related to the experience of pain. This study aimed to systematically analyze the literature on changes in pain perception during the anesthetic puncture of dental local anesthesia after Photobiomodulation Therapy (PBMT). Material and methods An electronic search was performed in eight primary databases (Embase, LILACS, BBO, LIVIVO, MedLine via PubMed, SciELO, Scopus, and Web of Science) and three additional ones (EASY, Google Scholar, and OATD) to partially capture the “gray literature”. The PICO strategy was used to identify randomized clinical trials evaluating the analgesic effect of PBMT in the anesthetic puncture site of dental local anesthesia compared to placebo or control groups, without restrictions on publication language and year. Two reviewers extracted the data and assessed the individual risk of bias of the eligible studies using the Cochrane Collaboration Risk of Bias Tool version 2.0. Results The electronic search found 3,485 records, of which eight met the eligibility criteria and were included in the qualitative synthesis. The studies were published from 2011 to 2022. None of the included studies had a low risk of bias. PBMT groups showed no significant difference in pain scores compared to placebo and control groups of most studies. Conclusion Based on a low to very low certainty of evidence, PBMT seems to have no effect on pain perception during anesthetic puncture in patients undergoing dental local anesthesia. PBMT. . (PBMT) Embase, Embase (Embase LILACS BBO LIVIVO PubMed SciELO Scopus Science EASY, EASY (EASY Scholar OATD gray literature. literature” year 20 2 0 2.0 3485 3 485 3,48 records synthesis 201 2022 evidence (PBMT 2. 348 48 3,4 202 34 4 3,

Resumo Fundamento Dados robustos sobre a curva de aprendizagem (LC) da substituição da válvula aórtica transcateter (TAVR) são escassos nos países em desenvolvimento. Objetivo Avaliar a LC da TAVR no Brasil ao longo do tempo. Métodos Analisamos dados do registro brasileiro de TAVR de 2008 a 2023. Pacientes de cada centro foram numerados cronologicamente em número sequencial de caso (NSC). A LC foi realizada usando um spline cúbico restrito ajustado para o EuroSCORE-II e o uso de próteses de nova geração. Ainda, os desfechos hospitalares foram comparados entre grupos definidos de acordo com o nível de experiência, com base no NSC: 1º ao 40º caso (experiência inicial), 41º ao 80º caso (experiência básica), 81º ao 120º caso (experiência intermediária) e 121º caso em diante (experiência alta). Análises adicionais foram conduzidas de acordo com o número de casos tratados antes de 2014 (>40 e ≤40 procedimentos). O nível de significância adotado foi p <0,05. Resultados Foram incluídos 3194 pacientes de 25 centros. A idade média foi 80,7±8,1 anos e o EuroSCORE II médio foi 7±7,1. A análise da LC demonstrou uma queda na mortalidade hospitalar ajustada após o tratamento de 40 pacientes. Um patamar de nivelamento na curva foi observado após o caso 118. A mortalidade hospitalar entre os grupos foi 8,6%, 7,7%, 5,9%, e 3,7% para experiência inicial, básica, intermediária e alta, respectivamente (p<0,001). A experiência alta foi preditora independente de mortalidade mais baixa (OR 0,57, p=0,013 vs. experiência inicial). Centros com baixo volume de casos antes de 2014 não mostraram uma redução significativa na probabilidade de morte com o ganho de experiência, enquanto centros com alto volume de casos antes de 2014 apresentaram uma melhora contínua após o caso de número 10. Conclusão Observou-se um fenômeno de LC para a mortalidade hospitalar do TAVR no Brasil. Esse efeito foi mais pronunciado em centros que trataram seus 40 primeiros casos antes de 2014 que naqueles que o fizeram após 2014. (LC (TAVR desenvolvimento tempo 200 2023 NSC. NSC . (NSC) EuroSCOREII geração Ainda º inicial , inicial) básica básica) alta. alta) 201 >40 (>4 ≤4 procedimentos. procedimentos procedimentos) 005 0 05 <0,05 319 2 80781 80 7 8 1 80,7±8, 771 7±7,1 4 118 86 6 8,6% 77 7,7% 59 5 9 5,9% 37 3 3,7 p<0,001. p0001 p<0,001 001 (p<0,001) OR 057 57 0,57 p0013 013 p=0,01 vs inicial. 10 Observouse Observou se 20 202 (NSC >4 (> ≤ 00 <0,0 31 8078 80,7±8 7±7, 11 8,6 7,7 5,9 3, p000 p<0,00 (p<0,001 0,5 p001 01 p=0,0 > ( <0, 807 80,7± 7±7 8, 7, 5, p00 p<0,0 (p<0,00 0, p=0, <0 80,7 7± p0 p<0, (p<0,0 p=0 < 80, p<0 (p<0, p= p< (p<0 (p< (p

Abstract Background Robust data on the learning curve (LC) of transcatheter aortic valve replacement (TAVR) are lacking in developing countries. Objective To assess TAVR’s LC in Brazil over time. Methods We analyzed data from the Brazilian TAVR registry from 2008 to 2023. Patients from each center were numbered chronologically in case sequence numbers (CSNs). LC was performed using restricted cubic splines adjusted for EuroSCORE-II and the use of new-generation prostheses. Also, in-hospital outcomes were compared between groups defined according to the level of experience based on the CSN: 1st to 40th (initial-experience), 41st to 80th (early-experience), 81st to 120th (intermediate-experience), and over 121st (high-experience). Additional analysis was performed grouping hospitals according to the number of cases treated before 2014 (>40 and ≤40 procedures). The level of significance adopted was <0.05. Results A total of 3,194 patients from 25 centers were included. Mean age and EuroSCORE II were 80.7±8.1 years and 7±7.1, respectively. LC analysis demonstrated a drop in adjusted in-hospital mortality after treating 40 patients. A leveling off of the curve was observed after case #118. In-hospital mortality across the groups was 8.6%, 7.7%, 5.9%, and 3.7% for initial-, early-, intermediate-, and high-experience, respectively (p<0.001). High experience independently predicted lower mortality (OR 0.57, p=0.013 vs. initial experience). Low-volume centers before 2014 showed no significant decrease in the likelihood of death with gained experience, whereas high-volume centers had a continuous improvement after case #10. Conclusion A TAVR LC phenomenon was observed for in-hospital mortality in Brazil. This effect was more pronounced in centers that treated their first 40 cases before 2014 than those that reached this milestone after 2014. (LC (TAVR countries TAVRs s time 200 2023 CSNs. CSNs . (CSNs) EuroSCOREII newgeneration new generation prostheses Also inhospital hospital CSN st th initialexperience, initialexperience , (initial-experience) earlyexperience, earlyexperience early (early-experience) intermediateexperience, intermediateexperience intermediate (intermediate-experience) highexperience. highexperience high (high-experience) 201 >40 (>4 ≤4 procedures. procedures procedures) 005 0 05 <0.05 3194 3 194 3,19 2 included 80781 80 7 8 1 80.7±8. 771 7±7.1 4 118 #118 Inhospital In 86 6 8.6% 77 7.7% 59 5 9 5.9% 37 3.7 initial, initial- early, early- intermediate, intermediate- highexperience, high-experience p<0.001. p0001 p p<0.001 001 (p<0.001) OR 057 57 0.57 p0013 013 p=0.01 vs experience. experience) Lowvolume Low volume highvolume 10 #10 20 202 (CSNs (initial-experience (early-experience (intermediate-experience (high-experience >4 (> ≤ 00 <0.0 319 19 3,1 8078 80.7±8 7±7. 11 #11 8.6 7.7 5.9 3. p000 p<0.00 (p<0.001 0.5 p001 01 p=0.0 #1 > ( <0. 31 3, 807 80.7± 7±7 8. 7. 5. p00 p<0.0 (p<0.00 0. p=0. # <0 80.7 7± p0 p<0. (p<0.0 p=0 < 80. p<0 (p<0. p= p< (p<0 (p< (p

RESUMO RACIONAL: Apesar da preferência pelo tratamento multimodal para o câncer gástrico, o abandono do tratamento quimioterápico bem como a necessidade de cirurgia “upfront” em pacientes obstruídos traz impactos negativos para o tratamento. A dificuldade de acesso ao tratamento em centros especializados no Sistema Único de Saúde (SUS) é um agravante. OBJETIVOS: Identificar vantagens, fatores prognósticos, complicações e sobrevida de terapias neoadjuvantes e adjuvantes no tratamento do câncer gástrico no cenário do SUS. MÉTODOS: Estudo retrospectivo incluindo 81 pacientes com adenocarcinoma gástrico submetidos a tratamento segundo os protocolos INT0116 (quimiorradioterapia adjuvante), CLASSIC (quimioterapia adjuvante), FLOT4-AIO (quimioterapia perioperatória) e cirurgia com intuito curativo (ressecção R0 e linfadenectomia D2) em um único centro oncológico entre 2015 e 2020. Indivíduos com outros tipos histológicos, coto gástrico, câncer de esôfago, outros protocolos de tratamento e estádio Ia ou IV foram excluídos. RESULTADOS: Os pacientes foram distribuídos em: FLOT4-AIO (26 pacientes), CLASSIC (25 pacientes) e INT0116 (30 pacientes). A média de idade foi 61 anos. Mais de 60% dos pacientes apresentaram estádio III patológico. A taxa de completude do tratamento foi 56%. A taxa de resposta patológica completa do grupo FLOT4-AIO foi 7,7%. Dentre os fatores prognósticos que impactaram a sobrevida global e sobrevida livre de doença tivemos etilismo, complicações pós-operatórias precoces, status anatomopatológico pN2 e pN3. A taxa de sobrevida global em 3 anos foi 64,9% sendo o subgrupo CLASSIC com melhor sobrevida (79,8%). CONCLUSÕES: A estratégia de tratamento do câncer gástrico varia de acordo com a necessidade de cirurgia inicial. O subgrupo CLASSIC apresentou melhor sobrevida global e sobrevida livre de doença. O esquema INT0116 também protegeu contra a mortalidade, mas não com significância estatística. Apesar do FLOT4-AIO ser o tratamento de escolha, a dificuldade na realização da neoadjuvância no âmbito do SUS impactou negativamente nos resultados devido à criticidade da ingesta alimentar e à pior tolerância ao tratamento. RACIONAL upfront “upfront (SUS agravante OBJETIVOS vantagens MÉTODOS 8 INT INT011 quimiorradioterapia adjuvante, adjuvante , adjuvante) quimioterapia FLOT4AIO FLOTAIO FLOT4 AIO FLOT perioperatória ressecção R D2 D 201 2020 histológicos esôfago excluídos RESULTADOS 26 (2 pacientes, 25 30 (3 pacientes. . 6 60 patológico 56 56% 77 7 7,7% etilismo pósoperatórias pós operatórias precoces pN pN3 649 64 9 64,9 79,8%. 798 79,8% 79 (79,8%) CONCLUSÕES inicial mortalidade estatística escolha INT01 20 202 2 ( 5 7,7 64, 79,8 (79,8% INT0 7, 79, (79,8 (79, (79 (7

ABSTRACT BACKGROUND: Despite the preference for multimodal treatment for gastric cancer, abandonment of chemotherapy treatment as well as the need for upfront surgery in obstructed patients brings negative impacts on the treatment. The difficulty of accessing treatment in specialized centers in the Brazilian Unified National Health System (SUS) scenario is an aggravating factor. AIMS: To identify advantages, prognostic factors, complications, and neoadjuvant and adjuvant therapies survival in gastric cancer treatment in SUS setting. METHODS: The retrospective study included 81 patients with gastric adenocarcinoma who underwent treatment according to INT0116 trial (adjuvant chemoradiotherapy), CLASSIC trial (adjuvant chemotherapy), FLOT4-AIO trial (perioperative chemotherapy), and surgery with curative intention (R0 resection and D2 lymphadenectomy) in a single cancer center between 2015 and 2020. Individuals with other histological types, gastric stump, esophageal cancer, other treatment protocols, and stage Ia or IV were excluded. RESULTS: Patients were grouped into FLOT4-AIO (26 patients), CLASSIC (25 patients), and INT0116 (30 patients). The average age was 61 years old. More than 60% of patients had pathological stage III. The treatment completion rate was 56%. The pathological complete response rate of the FLOT4-AIO group was 7.7%. Among the prognostic factors that impacted overall survival and disease-free survival were alcoholism, early postoperative complications, and anatomopathological status pN2 and pN3. The 3-year overall survival rate was 64.9%, with the CLASSIC subgroup having the best survival (79.8%). CONCLUSIONS: The treatment strategy for gastric cancer varies according to the need for initial surgery. The CLASSIC subgroup had better overall survival and disease-free survival. The INT0116 regimen also protected against mortality, but not with statistical significance. Although FLOT4-AIO is the preferred treatment, the difficulty in carrying out neoadjuvant treatment in SUS scenario had a negative impact on the results due to the criticality of food intake and worse treatment tolerance. BACKGROUND (SUS factor AIMS advantages complications setting METHODS 8 INT INT011 chemoradiotherapy, chemoradiotherapy , chemoradiotherapy) chemotherapy, chemotherapy) FLOT4AIO FLOTAIO FLOT4 AIO FLOT perioperative R0 R (R D lymphadenectomy 201 2020 types stump protocols excluded RESULTS 26 (2 patients, patients) 25 30 (3 patients. . 6 old 60 III 56 56% 77 7 7.7% diseasefree disease free alcoholism pN pN3 3year year 3 649 64 9 64.9% 79.8%. 798 79.8% 79 (79.8%) CONCLUSIONS mortality significance tolerance INT01 20 202 2 ( 5 7.7 64.9 79.8 (79.8% INT0 7. 64. 79. (79.8 (79. (79 (7