Abstract Objectives To investigate the impact of Three-Dimensional (3D) laparoscopy compared to traditional laparotomy on serum tumor markers and coagulation function in patients diagnosed with early-stage Endometrial Cancer (EC). Method The authors retrospectively analyzed the clinical data of 75 patients diagnosed with early-stage EC and categorized them into two groups based on the surgical techniques employed. The 3D group consisted of 36 patients who underwent 3D laparoscopic surgery, while the Laparotomy group comprised 39 patients who underwent traditional laparotomy. The authors then compared the alterations in serum tumor markers and coagulation function between the two groups. Results Postoperatively, serum levels of CA125, CA199, and HE4 were notably reduced in both groups on the third day, with the levels being more diminished in the 3D group than in the Laparotomy Group (p < 0.05). Conversely, FIB levels escalated significantly in both groups on the third-day post-surgery, with a more pronounced increase in the 3D group. Additionally, PT and APTT durations were reduced and were more so in the 3D group than in the laparotomy group (p < 0.05). Conclusions When juxtaposed with traditional laparotomy, 3D laparoscopic surgery for early-stage EC appears to be more efficacious, characterized by reduced complications, and expedited recovery. It can effectively mitigate serum tumor marker levels, attenuate the inflammatory response and damage to immune function, foster urinary function recovery, and enhance the quality of life. However, it exerts a more significant influence on the patient's coagulation parameters, necessitating meticulous prevention and treatment strategies for thromboembolic events in clinical settings. ThreeDimensional Three Dimensional D (3D earlystage early stage EC. . (EC) 7 employed 3 Postoperatively CA125 CA CA199 HE day p 0.05. 005 0.05 0 05 0.05) Conversely thirdday postsurgery, postsurgery post post-surgery Additionally efficacious complications recovery life However patient s parameters settings (EC CA12 CA19 00 0.0 CA1 0.

Abstract Objective: The objective of this study was to investigate the effects of activity-based locomotor training (ABLT) on motor function and walking ability in children with spinal cord injury (SCI). Materials and methods: The Chinese National Knowledge Infrastructure, WanFang, VIP, PubMed, and Web of Science databases were searched for related studies, with two reviewers subsequently evaluating the literature quality using the Cochrane Handbook. Results: A total of 11 studies were eligible, while only one met the ABLT standard program criteria. Overall, ABLT significantly improved the lower limb motor function, increased walking speed and distance, and improved the daily living ability of children with SCI. Conclusions: The ABLT strategy is of great significance to the motor function and walking ability of children with SCI. At present, there exist few studies on the application of ABLT for pediatric SCI. Further control studies with a larger sample size are required to improve the ABLT program guidelines for children with SCI.

Resumen Objetivo: Discuta el impacto del entrenamiento ejercicio basado en la actividad en la lesión de la médula espinal en la función de movimiento de los niños y la capacidad de caminar. Materials y métodos: Según China Zhiwang, Wanfang, VIP, PubMed, Science Network y otros documentos relacionados como fuente de datos. Dos revisores usan calidad de evaluación manual de Cochrane. Resultados: Un total de 11 estudios cumplen con las condiciones. Solo hay un estudio que cumple con los proyectos estándar de ABLT. General, ABLT mejora significativamente la función de los niños con lesiones de la médula espinal, aumenta la velocidad y la distancia de caminar y mejora la capacidad de la vida diaria. Conclusión: La estrategia ABLT es de gran importancia para la función de movimiento de los niños de la médula espinal y la capacidad de caminar. En la actualidad, ABLT tiene menos investigación en lesión pediátrica de la médula espinal. Es necesario mostrar la cantidad de muestra y controlar la investigación para mejorar las pautas del plan ABLT para el daño de la médula espinal a los niños.

Resumen Dentro del campo de investigación pragmático-discursivo, los marcadores del discurso despiertan cada vez más el interés de los lingüistas. A medida que se incrementa el número de especialistas que se dedican al estudio lingüístico del español y el chino mandarín, han surgido varios trabajos de carácter contrastivo sobre los marcadores del discurso; la mayoría se centra en comparar determinados grupos de marcadores en ambas lenguas y examinar su aplicación didáctica en el aula. Dado que dicha línea de investigación sigue floreciendo -y aún quedan bastantes aspectos por analizar-, muchos marcadores discursivos, por su índole polifuncional, merecen un análisis individual y profundo. El presente trabajo tiene como objetivo acercarse a los marcadores del discurso bueno y好 (hǎo) -de gran utilidad en las dos lenguas-, los cuales manifiestan ciertas similitudes semántico-pragmáticas. Para llevar a cabo este objetivo, el análisis se enfoca en las formas y funciones de ambos marcadores con base en investigaciones intralingüísticas.

Abstract Within the field of pragmatic-discursive research, discourse markers are increasingly attracting the interest of linguists. As the number of scholars engaged in linguistic research between Spanish and Mandarin Chinese increases, several works on discourse markers of a contrastive nature are coming to light, most of them focusing on comparing certain groups of markers in both languages and examining their didactic application in the classroom. As this line of research continues to flourish -and there are still many aspects to be discovered-, many discourse markers, due to their polyfunctional nature, deserve an individual and deep analysis. The present work aims to carry out an approach to bueno and好 (hǎo), a couple of discourse markers of great utility in both languages that manifest certain semantic-pragmatic similarities, focusing on their forms and functions based on the most relevant intralinguistic research.

Abstract The meticulous design and data processing of the SHPB test necessitate an exact analysis of the elastic segment to ensure an accurate acquisition of dynamic parameters. When other conditions align with theoretical requirements, a pressing question arises: Is the Young's modulus obtained through the stress wave theory while processing SHPB test data accurate? This is an issue that must be clearly addressed. To tackle this question, analytical expressions for parameters such as stress difference and particle velocity difference were derived. This allowed for the analysis of curve characteristics, influencing factors, and their underlying mechanisms. Building on this, equations for determining Young's modulus were deduced. The research indicates that when the wave impedance ratio is relatively large, the Young's modulus provided by the "two-wave method" inherently has a significant theoretical error. However, when the incident wave is sufficiently gradual, the Young's modulus deduced by the "three-wave method" proves to be remarkably accurate. requirements arises Youngs Young s addressed derived characteristics factors mechanisms large twowave two method error However gradual threewave three

Resumen Introducción: El desequilibrio energético entre la ingesta y el consumo a largo plazo es la razón principal de la obesidad en los estudiantes universitarios, por lo tanto, la pérdida de peso también debe combinar una intervención inversamente proporcional. Aprovechando esta premisa, cada vez son más los estudios que combinan entrenamiento físico y dietas con el fin de restablecer la salud física en esta parte de la población. Objetivo: Estudiar los impactos del entrenamiento aeróbico asociado a dieta hipocalórica sobre la constitución y el metabolismo de estudiantes universitarios obesos. Métodos: Mediante una encuesta con cuestionario y un programa experimental con una duración total de 4 semanas de entrenamiento aeróbico y dieta hipocalórica, 20 estudiantes universitarios obesos se presentaron como voluntarios para el proyecto de intervención. El protocolo de ejercicios para la composición del entrenamiento y el menú dietético siguieron las recomendaciones actualizadas de la literatura científica. Al final del experimento, se analizaron y discutieron estadísticamente los datos pertinentes recogidos. Resultados: Tras la intervención dietética asociada al entrenamiento aeróbico, el índice de IMC de los estudiantes universitarios se redujo de 28,075 a 26,378; el índice metabólico basal aumentó de 1581,046 kcal a 1681,317 kcal. Conclusión: El entrenamiento aeróbico asociado a una dieta hipocalórica mostró un efecto significativo en la reducción de grasa en estudiantes universitarios obesos. La eficacia de esta asociación promovió un mejor efecto conjunto sobre el resultado en comparación con los planes individuales de pérdida de peso. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento. Introducción tanto proporcional premisa población Objetivo Métodos 2 científica experimento recogidos Resultados 28075 28 075 28,07 26,378 26378 26 378 1581046 1581 046 1581,04 1681317 1681 317 1681,31 Conclusión II tratamiento 2807 07 28,0 26,37 2637 37 158104 158 04 1581,0 168131 168 31 1681,3 280 0 28, 26,3 263 3 15810 15 1581, 16813 16 1681, 26, 1

ABSTRACT Introduction: The long-term energy imbalance between intake and consumption is the main reason for obesity in college students. Therefore, weight loss should also combine an inversely proportional intervention. Based on this premise, a growing number of studies combine physical training and diet to restore physical health in this population group. Objective: Study the impacts of endurance training associated with a low-calorie diet on the constitution and metabolism of obese college students. Methods: Through a questionnaire survey and a 4-week experimental endurance training program and hypocaloric diet, 20 obese college students volunteered for the intervention project. The exercise protocol for the training composition and the diet menu followed the updated recommendations in the scientific literature. At the end of the experiment, the relevant data collected were statistically analyzed and discussed. Results: After the diet intervention associated with endurance training, the BMI index of college students reduced from 28,075 to 26,378; the basal metabolic rate increased from 1581,046 kcal to 1681,317 kcal. Conclusion: Endurance training associated with a hypocaloric diet significantly reduced fat in obese college students. The efficacy of this association promoted a better joint effect on the outcome, compared to individual weight loss plans. Level of evidence II; Therapeutic studies - investigation of treatment outcomes. Introduction longterm long term Therefore premise group Objective lowcalorie low calorie Methods 4week week 4 2 project literature experiment discussed Results 28075 28 075 28,07 26,378 26378 26 378 1581046 1581 046 1581,04 1681317 1681 317 1681,31 Conclusion outcome plans II outcomes 2807 07 28,0 26,37 2637 37 158104 158 04 1581,0 168131 168 31 1681,3 280 0 28, 26,3 263 3 15810 15 1581, 16813 16 1681, 26, 1

RESUMO Introdução: O desequilíbrio energético entre ingestão e consumo a longo prazo é o principal motivo da obesidade nos universitários, portanto, a perda de peso também deve combinar uma intervenção inversamente proporcional. Valendo-se dessa premissa, são crescentes os estudos que combinam treinos físicos e dietas com o propósito de restaurar a saúde física nessa parcela da população. Objetivo: Estudar os impactos do treino aeróbico associado a dieta hipocalórica sobre a constituição e o metabolismo de estudantes universitários obesos. Métodos: Através de uma pesquisa por questionário e um programa experimental com duração total de 4 semanas de treino aeróbico e dieta hipocalórica, 20 universitários obesos voluntariaram-se para o projeto de intervenção. O protocolo de exercícios para a composição do treino e o cardápio da dieta seguiram as recomendações atualizadas da literatura científica. Ao final do experimento, os dados relevantes coletados foram analisados estatisticamente e discutidos. Resultados: Após a intervenção da dieta associada ao treino aeróbico, o índice IMC de estudantes universitários reduziu de 28.075 para 26.378; o índice metabólico basal aumentou de 1581.046 kcal para 1681.317 kcal. Conclusão: O treino aeróbico associado à dieta hipocalórica demonstrou um efeito significativo na diminuição da gordura dos universitários obesos. A eficácia dessa associação promoveu um melhor efeito conjunto no resultado, em comparação a planos individuais de emagrecimento. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento. Introdução portanto proporcional Valendose Valendo se premissa população Objetivo Métodos 2 voluntariaramse voluntariaram científica experimento discutidos Resultados 28075 28 075 28.07 26.378 26378 26 378 1581046 1581 046 1581.04 1681317 1681 317 1681.31 Conclusão resultado emagrecimento II tratamento 2807 07 28.0 26.37 2637 37 158104 158 04 1581.0 168131 168 31 1681.3 280 0 28. 26.3 263 3 15810 15 1581. 16813 16 1681. 26. 1

Abstract In this paper, the relationship between Kernel average misorientation (KAM), geometrically necessary dislocation (GND) density and dislocation structures of Nb-bearing austenitic stainless steel under low cycle fatigue (LCF) was studied at 600°C at the total strain amplitude ranged from 0.3% to 1.0%. The results based on EBSD analysis show that the GND density in fatigue specimens gradually increases with the increase of strain amplitude. Under LCF loading, the dislocation structures are mainly planar slip bands (PSBs) and the cell structures. With the increase of strain amplitude, the number of PSBs increases with decrease in width, and the average diameter of cells also decreases. The PSBs originate due to the dynamic strain aging (DSA) effect, and DSA is more significant under high strain amplitude. The average diameter of cell structures has a specific relationship with GND density.

Abstract INTRODUCTION: Artemisinin-based combination therapy (ACT), such as artemisinin-piperaquine (AP), dihydroartemisinin-piperaquine (DP), and artemether-lumefantrine (AL), is the first-line treatment for malaria in many malaria-endemic areas. However, we lack a detailed evaluation of the cardiotoxicity of these ACTs. This study aimed to analyze the electrocardiographic effects of these three ACTs in malaria patients. METHODS: We analyzed the clinical data of 89 hospitalized patients with falciparum malaria who had received oral doses of three different ACTs. According to the ACTs administered, these patients were divided into three treatment groups: 27 treated with AP (Artequick), 31 with DP (Artekin), and 31 with AL (Coartem). Electrocardiograms and other indicators were recorded before and after the treatment. The QT interval was calculated using Fridericia’s formula (QTcF) and Bazett’s formula (QTcB). RESULTS: Both QTcF and QTcB interval prolongation occurred in all three groups. The incidence of such prolongation between the three groups was not significantly different. The incidence of both moderate and severe prolongation was not significantly different between the three groups. The ΔQTcF and ΔQTcB of the three groups were not significantly different. The intra-group comparison showed significant prolongation of QTcF after AL treatment. CONCLUSIONS: Clinically recommended doses of DP, AL, and AP may cause QT prolongation in some malaria patients but do not cause torsades de pointes ventricular tachycardia or other arrhythmias.

Abstract This study aimed to investigate the potential of a novel preparation strategy for glycosylated hydrolysate by liquid fermentation in order to provide a high-quality glycosylated hydrolysate. Protein solubility, surface hydrophobicity and antioxidant activity were evaluated. The results of Fourier transform infrared spectra demonstrated the occurrence of glycosylation reaction. The results of Fluorescence emission spectroscope revealed the decrease of tertiary conformation stability. Circular dichroism spectra revealed significant decrease in α-helix and increase in β-sheet and random coil by glycosylation reaction. In comparison with zein hydrolysate, glycosylated hydrolysate had lower surface hydrophobicity but higher in solubility and in vitro digestibility due to glycosylation. Glycosylated hydrolysate presented higher ABTS (2,2'-Azinobis [3-ethylbenzothiazoline-6-sulfonic acid]-diammonium salt) and superoxide radicals scavenging activities as well as Cu2+ chelating capacity. It is concluded that the glycosylation confer an open structure and modified properties of zein, and glycosylated hydrolysate is a potential ingredient with better hydration and antioxidant activities than zein hydrolysate.

Abstract Purpose To investigate the effects of grape seed proanthocyanidin B2 (GSPB2) preconditioning on oxidative stress and apoptosis of renal tubular epithelial cells in mice after renal ischemia-reperfusion (RIR). Methods Forty male ICR mice were randomly divided into 4 groups: Group A: mice were treated with right nephrectomy. Group B: right kidney was resected and the left renal vessel was clamped for 45 minutes. Group C: mice were intraperitoneally injected with GSPB2 before RIR established. Group D: mice were intraperitoneally injected with GSPB2 plus brusatol before RIR established. Creatinine and urea nitrogen of mice were determined. Pathological and morphological changes of kidney were checked. Expressions of Nrf-2, HO-1, cleaved-caspase3 were detected by Western-blot. Results Compared to Group B, morphology and pathological damages of renal tissue were less serious in Group C. Western-blot showed that expressions of Nrf-2 and HO-1 in Group C were obviously higher than those in Group B. The expression of cleaved-caspase3 in Group C was significantly lower than that in Group B. Conclusion GSPB2 preconditioning could attenuate renal oxidative stress injury and renal tubular epithelial cell apoptosis by up-regulating expressions of Nrf-2 and HO-1 and down-regulating the expression of cleaved-caspase-3, but the protective effect could be reversed by brusatol.

Abstract INTRODUCTION: Concern regarding the cardiotoxicity of antimalarials has been renewed because of their potential to cause QT/QTc interval prolongation related to torsade de pointes (TdP). Artemisinin-piperaquine (AP) is considered an effective artemisinin-based combination therapy (ACT) for malaria. METHODS: This study involved a retrospective analysis of clinical data of 93 hospitalized malaria patients who had received AP orally. Electrocardiograms (ECGs) were obtained at specific time points in the original study. RESULTS: Some cases of QT prolongation were observed. However, no TdP was found. CONCLUSIONS: AP may cause QT interval prolongation in some malaria patients but may not lead to TdP.

Microstructural phase of linepipe steels depends on different isothermal conditions. Thermal cycling testing of X90 linepipe steel was conducted using a thermomechanical simulator. The results have shown that with increased holding time, the microstructure constituents change from the martensite and bainitic ferrites to granular bainite and polygonal ferrite. There was the amount of martensite in the microstructure for isothermal holding times of 5 and 10 s at 700ºC. The effects of the martensite strengthening were weak. The changes of the hardness curve are decided by microstructural phase and the precipitation behavior. The interphase precipitation seems to begin for isothermal holding times greater than 30 s. It has a peak value for isothermal holding time of 600 s. Some fcc (Ti, Nb) (N, C) particles which belong to the MX-type precipitates were obtained at this condition. It is a major microstructural contributor to the hardness. The beneficial effects of the precipitates decreased considerably due to coarsening of the precipitates with prolonged holding, which results in the hardness quickly dropping. As a result, the hardness exhibited a low value after isothermal holding for 3600 s because the extent of precipitation strengthening was lessened and a lot of polygonal ferrites were formed.

ABSTRACT Purpose To investigate the incidence and pathologic characteristics of prostate cancer (PCa) incidentally discovered at the time of radical cystectomy and its impact on overall survival. Materials and Methods A single center retrospective study of 762 male patients who underwent radical cystoprostatectomy from Jan 1994 to Dec 2012. Results Of all included patients, 132 (17.3%) were found to have PCa. Patients with incidental PCa had a significantly higher mean age (69.2 vs. 62.2 years, P=0.015). Among the 132 patients with PCa, prostate specific antigen (PSA) analysis was available in 76 patients (57.6%), with a median value of 1.06ng/mL, and 61 (80.3%) patients had a PSA value below 4ng/mL. Four hundred and thirty-six patients (57.1%) were successfully followed, with a median duration of 46.5 months. The overall 5-year survival rate was 62.1%, and the 5-year cancer–specific survival rate was 72%. PCa recurrence was defined by two consecutive PSA values of >0.2 ng/mL and rising, and no PCa recurrence occurred. According to a univariate analyses, incidental PCa was not associated with cancer-specific survival (P=0.192) or overall survival (P=0.493). According to univariate analyses, the overall survival of patients with PCa was not associated with prostate cancer staging, PSA value, or Gleason score (All P values>0.05). Conclusions Prostate cancer incidentally discovered at the time of radical cystectomy does not decrease overall survival. Patients with incidental PCa were older than those without. The PSA value before operation is not helpful for predicting incidental prostate cancers.

ABSTRACT Objectives: To evaluate the prognosis of non-metastatic T3a renal cell carcinoma (RCC) with partial nephrectomy (PN). Patients and Methods: We retrospectively evaluated 125 patients with non-metastatic T3a RCC. Patients undergoing PN and radical nephrectomy (RN) were strictly matched by clinic-pathologic characteristics. Log-rank test and Cox regression model were used for univariate and multivariate analysis. Results: 18 pair patients were matched and the median follow-up was 35.5 (10-86) months. PN patients had a higher postoperative eGFR than RN patients (P=0.034). Cancer-specific survival (CSS) and recurrence-free survival (RFS) did not differ between two groups (P=0.305 and P=0.524). On multivariate analysis, CSS decreased with positive surgical margin and anemia (both P <0.01) and RFS decreased with Furhman grade, positive surgical margin, and anemia (all P<0.01). Conclusions: For patients with non-metastatic pT3a RCC, PN may be a possible option for similar oncology outcomes and better renal function.

OBJECTIVES: No studies have compared monoaxial and polyaxial pedicle screws with regard to the von Mises stress of the instrumentation, intradiscal pressures of the adjacent segment and adjacent segment degeneration. METHODS: Short-segment monoaxial/polyaxial pedicle screw fixation techniques were compared using finite element methods, and the redistributed T11-L1 segment range of motion, largest maximal von Mises stress of the instrumentation, and intradiscal pressures of the adjacent segment under displacement loading were evaluated. Radiographic results of 230 patients with traumatic thoracolumbar fractures treated with these fixations were reviewed, and the sagittal Cobb’s angle, vertebral body angle, anterior vertebral body height of the fractured vertebrae and adjacent segment degeneration were calculated and evaluated. RESULTS: The largest maximal values of the von Mises stress were 376.8 MPa for the pedicle screws in the short-segment monoaxial pedicle screw fixation model and 439.9 MPa for the rods in the intermediate monoaxial pedicle screw fixation model. The maximal intradiscal pressures of the upper adjacent segments were all greater than those of the lower adjacent segments. The maximal intradiscal pressures of the monoaxial pedicle screw fixation model were larger than those in the corresponding segments of the normal model. The radiographic results at the final follow-up evaluation showed that the mean loss of correction of the sagittal Cobb’s angle, vertebral body angle and anterior vertebral body height were smallest in the intermediate monoaxial pedicle screw fixation group. Adjacent segment degeneration was less likely to be observed in the intermediate polyaxial pedicle screw fixation group but more likely to be observed in the intermediate monoaxial pedicle screw fixation group. CONCLUSION: Smaller von Mises stress in the pedicle screws and lower intradiscal pressure in the adjacent segment were observed in the polyaxial screw model than in the monoaxial pedicle screw fixation spine models. Fracture-level fixation could significantly correct kyphosis and reduce correction loss, and adjacent segment degeneration was less likely to be observed in the intermediate polyaxial pedicle screw fixation group.