The metal-organic frameworks (MOFs) UiO-66-NH2, UiO-66-2,5-(OH)2, UiO-66-NO2, UiO-66-NDC, and UiO-66-BPDC were synthesized under solvothermal conditions using different functionalized organic linkers. The structures and properties of the samples were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, and nitrogen adsorption-desorption isotherms. The crystal structures of these functionalized UiO-66(Zr) forms were similar. A series of functionalized UiO-66(Zr) samples were used in the adsorption of carbon dioxide (CO2). UiO-66-NH2 had the highest CO2 adsorption capacity (about 3.35 mmol g-1) due to its small polar -NH2 group. The performance of UiO-66-NH2 in CO2 adsorption at different temperatures was also determined. The amino-functionalized material possessed better adsorption properties at 273 K than at 303 K, while the CO2 working capacity of UiO-66-NH2 was fully recovered after cyclic regeneration. metalorganic metal MOFs (MOFs UiO66NH2, UiO66NH2 UiONH UiO 66 NH2, NH2 NH UiO662,5OH2, UiO6625OH2 UiOOH 2,5 OH 2, 2 5 UiO-66-2,5-(OH)2 UiO66NO2, UiO66NO2 UiONO NO2, NO2 NO UiO-66-NO2 UiO66NDC, UiO66NDC UiONDC NDC, NDC UiO-66-NDC UiO66BPDC UiOBPDC BPDC linkers Xray X ray diffraction spectroscopy analysis microscopy adsorptiondesorption desorption isotherms UiO66Zr UiOZr Zr UiO-66(Zr similar CO2. CO . (CO2) UiO-66-NH about 335 3 35 3.3 g1 g 1 g-1 -NH group determined aminofunctionalized amino 27 30 regeneration UiO66NH 6 UiO662 5OH2 UiO662,5OH2 UiO6625OH 25 UiO-66-2,5-(OH) UiO66NO UiO-66-NO (CO2 33 3. g- UiO66 5OH UiO662,5OH UiO-66-2,5-(OH (CO UiO6

BiOCl/KBiO3 p-n heterostructures with hierarchical mesoporous architectures were successfully synthesized via a facile in situ method. The X-ray powder diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and scanning electron microscope (SEM) results indicate the formation of heterojunctions between BiOCl and KBiO3. The photocatalytic performance of the as-prepared samples was investigated by the degradation of dye Rhodamine B (RhB) under visible light irradiation. BiOCl/KBiO3 composite has never been used to photodegrade the RhB which is a common dye and very difficult to degrade. The results demonstrated that KBiO3 combined with proper amount of BiOCl nanosheets exhibited high efficiency in the photocatalytic process, and BiOCl/KBiO3 with the molar ratio of 70/30 demonstrated the highest photocatalytic activity due to its large surface area, excellent charge separation characteristics and the suppressed recombination of electron-hole pairs. The results of active species detection reveal that the superoxide radical anions (O2-), hydroxyl free radicals (·OH), photogenerated holes (h+) and photogenerated electrons (e-) reactive species work together for the photocatalytic degradation of RhB. A possible and new mechanism of photocatalysis that differs from other teams was also explored and proposed. The present study will benefit the development of the new p-n heterojunction photocatalysts and would be of great importance to meet ever-increasing environmental demands in the future. BiOClKBiO3 BiOClKBiO KBiO BiOCl/KBiO pn p n method Xray X ray XRD, XRD , (XRD) XPS (XPS SEM (SEM asprepared as prepared (RhB irradiation degrade process 7030 70 30 70/3 area electronhole hole pairs O2, O2 O (O2-) ·OH, OH ·OH (·OH) h+ h (h+ e (e- proposed everincreasing ever increasing future (XRD 703 7 3 70/ (O2- (·OH (h (e (O2 (O

The lightly micro-polluted raw water of Yangtze River (YRW) in autumn was treated via enhanced coagulation by composite coagulants composed of polyaluminium chloride (PAC) and polydimethyldiallylammonium chloride (PDMDAAC), named PAC/PDMDAAC. Coagulation mechanism and removal efficiency were investigated by assessing the water quality parameters of the resulting supernatant, i.e. turbidity, COD Mn, and NH3-N, at the same dosage and supernatant turbidity (SDST) point as using PAC only, with controlled residual turbidity of 1.0-1.50 NTU to mimic drinking water production plant supernatant condition when using lightly micro-polluted water as raw water source . In addition, the zeta potential, floc morphology, and size analysis under the condition of SDST using PAC and composite coagulants PAC/PDMDAAC for getting insight about removal mechanism were done. The results showed that, firstly, most of the composite coagulants PAC/PDMDAAC with intrinsic viscosity [η] = 0.65, 1.60, and 2.6 dL/g; and mass ratio PAC:PDMDAAC of 5:1, 10:1, and 20:1 (mm)) could meet the requirements of controlled supernatant turbidity between 1.0 and 1.5 NTU to mimic drinking water production plant condition using YRW (Nanjing section) that comply with the new national drinking water standards. Secondly, the seven kinds of composite coagulants PAC/PDMDAAC can maintained the advantage of enhanced coagulation removal efficiency within the SDST point as using PAC only. The COD Mn and ammonia nitrogen removal rates using composite coagulants at SDST points were 0-6.19 %; 0-15.62%, respectively higher than using PAC only. Finally, this study deepened and expanded the existing research knowledge about composite coagulant PAC/PDMDAAC and offered the maximum limitations in removing the water quality parameters via enhanced coagulation treatment of lightly micro-polluted surface raw water in order to meet new national drinking water standards.

Abstract Despite the record speed of developing vaccines and therapeutics against the SARS-CoV-2 virus, it is not a given that such success can be secured in future pandemics. In addition, COVID-19 vaccination and application of therapeutics remain low in developing countries. Rapid and low cost mass production of antiviral IgY antibodies could be an attractive alternative or complementary option for vaccine and therapeutic development. In this article, we rapidly produced SARS-CoV-2 antigens, immunized hens and purified IgY antibodies in 2 months after the SARS-CoV-2 gene sequence became public. We further demonstrated that the IgY antibodies competitively block RBD binding to ACE2, neutralize authentic SARS-CoV-2 virus and effectively protect hamsters from SARS-CoV-2 challenge by preventing weight loss and lung pathology, representing the first comprehensive study with IgY antibodies. The process of mass production can be easily implemented in most developing countries and hence could become a new vital option in our toolbox for combating viral pandemics. This study could stimulate further studies, optimization and potential applications of IgY antibodies as therapeutics and prophylactics for human and animals.

Abstract Studies have suggested that endoplasmic reticulum stress (ERS) is involved in neurological dysfunction and that electroacupuncture (EA) attenuates neuropathic pain (NP) via undefined pathways. However, the role of ERS in the anterior cingulate cortex (ACC) in NP and the effect of EA on ERS in the ACC have not yet been investigated. In this study, an NP model was established by chronic constriction injury (CCI) of the left sciatic nerve in rats, and mechanical and cold tests were used to evaluate behavioral hyperalgesia. The protein expression and distribution were evaluated using western blotting and immunofluorescence. The results showed that glucose-regulated protein 78 (BIP) and inositol-requiring enzyme 1α (IRE-1α) were co-localized in neurons in the ACC. After CCI, BIP, IRE-1α, and phosphorylation of IRE-1α were upregulated in the ACC. Intra-ACC administration of 4-PBA and Kira-6 attenuated pain hypersensitivity and downregulated phosphorylation of IRE-1α, while intraperitoneal injection of 4-PBA attenuated hyperalgesia and inhibited the activation of P38 and JNK in ACC. In contrast, ERS activation by intraperitoneal injection of tunicamycin induced behavioral hyperalgesia in naive rats. Furthermore, EA attenuated pain hypersensitivity and inhibited the CCI-induced overexpression of BIP and pIRE-1α. Taken together, these results demonstrate that EA attenuates NP by suppressing BIP- and IRE-1α-mediated ERS in the ACC. Our study presents novel evidence that ERS in the ACC is implicated in the development of NP and provides insights into the molecular mechanisms involved in the analgesic effect of EA.

Abstract Background As a common disabling disease, irreversible neuronal death due to spinal cord injury (SCI) is the root cause of functional impairment; however, the capacity for neuronal regeneration in the developing spinal cord tissue is limited. Therefore, there is an urgent need to investigate how defective neurons can be replenished and functionally integrated by neural regeneration; the reprogramming of intrinsic cells into functional neurons may represent an ideal solution. Methods A mouse model of transection SCI was prepared by forceps clamping, and an adeno-associated virus (AAV) carrying the transcription factors NeuroD1 and Neurogenin-2(Ngn2) was injected in situ into the spinal cord to specifically overexpress these transcription factors in astrocytes close to the injury site. 5-bromo-2´-deoxyuridine (BrdU) was subsequently injected intraperitoneally to continuously track cell regeneration, neuroblasts and immature neurons marker expression, neuronal regeneration, and glial scar regeneration. In addition, immunoprotein blotting was used to measure the levels of transforming growth factor-β (TGF-β) pathway-related protein expression. We also evaluated motor function, sensory function, and the integrity of the blood-spinal cord barrier(BSCB). Results The in situ overexpression of NeuroD1 and Ngn2 in the spinal cord was achieved by specific AAV vectors. This intervention led to a significant increase in cell regeneration and the proportion of cells with neuroblasts and immature neurons cell properties at the injury site(p < 0.0001). Immunofluorescence staining identified astrocytes with neuroblasts and immature neurons cell properties at the site of injury while neuronal marker-specific staining revealed an increased number of mature astrocytes at the injury site. Behavioral assessments showed that the intervention did not improve The BMS (Basso mouse scale) score (p = 0.0726) and gait (p > 0.05), although the treated mice had more sensory sensitivity and greater voluntary motor ability in open field than the non-intervention mice. We observed significant repair of the BSCB at the center of the injury site (p < 0.0001) and a significant improvement in glial scar proliferation. Electrophysiological assessments revealed a significant improvement in spinal nerve conduction (p < 0.0001) while immunostaining revealed that the levels of TGF-β protein at the site of injury in the intervention group were lower than control group (p = 0.0034); in addition, P70 s6 and PP2A related to the TGF-β pathway showed ascending trend (p = 0.0036, p = 0.0152 respectively). Conclusions The in situ overexpression of NeuroD1 and Ngn2 in the spinal cord after spinal cord injury can reprogram astrocytes into neurons and significantly enhance cell regeneration at the injury site. The reprogramming of astrocytes can lead to tissue repair, thus improving the reduced threshold and increasing voluntary movements. This strategy can also improve the integrity of the blood-spinal cord barrier and enhance nerve conduction function. However, the simple reprogramming of astrocytes cannot lead to significant improvements in the striding function of the lower limbs.

This study aimed to analyze the safety and applicability of a 90-min duration of infusion (SDI) of obinutuzumab in patients with B-cell non-Hodgkin's lymphoma (NHL) in a tertiary hospital in China. This exploratory clinical trial was performed at Jiangsu Province Hospital. All patients were treated with the standard infusion regimen for the first infusion. If no grade ≥3 infusion-related reactions (IRRs) occurred, the subsequent infusions were given as SDI. The primary endpoint was the incidence of IRR during the standard infusion (3-4 h) and 90-min SDI regimens. This study enrolled 208 patients and all completed cycle 1. Forty-one patients (19.71%) had IRRs: five (2.40%) with grade 1, twenty-eight (13.46%) with grade 2, and eight (3.85%) with grade 3. The 41 patients had 71 IRRs, mainly fever (40.85%), chest pain/tightness (12.68%), and dyspnea (9.86%). The occurrence of IRRs in the first infusion was significantly lower in patients who received oral acetaminophen prophylaxis than those who did not (10.72% vs 30.21%, P<0.001). For the subsequent cycles with 90-min SDI, only two (0.25%) IRRs occurred among 814 infusions (one grade 1 hand numbness and one grade 2 chill/fever). The 90-min obinutuzumab SDI might be safe and feasible in patients with B-cell NHL in China. 90min min 90 (SDI Bcell B cell nonHodgkins non Hodgkin s (NHL China Hospital 3 ≥ infusionrelated related (IRRs 34 4 (3- h regimens 20 Fortyone Forty 19.71% 1971 19 (19.71% 2.40% 240 40 (2.40% twentyeight twenty 13.46% 1346 13 46 (13.46% 3.85% 385 85 (3.85% 7 40.85%, 4085 40.85% , (40.85%) paintightness pain tightness 12.68%, 1268 12.68% 12 68 (12.68%) 9.86%. 986 9.86% . 9 86 (9.86%) 10.72% 1072 10 72 (10.72 3021 30 21 30.21% P<0.001. P0001 P P<0.001 0 001 P<0.001) 0.25% 025 25 (0.25% 81 chill/fever. chillfever chill/fever chill chill/fever) (3 19.71 197 (19.71 2.40 24 (2.40 13.46 134 (13.46 3.85 38 8 (3.85 408 40.85 (40.85% 126 12.68 6 (12.68% 98 9.86 (9.86% 10.72 107 (10.7 302 30.21 P000 P<0.00 00 0.25 02 (0.25 ( 19.7 (19.7 2.4 (2.4 13.4 (13.4 3.8 (3.8 40.8 (40.85 12.6 (12.68 9.8 (9.86 10.7 (10. 30.2 P00 P<0.0 0.2 (0.2 19. (19. 2. (2. 13. (13. (3. 40. (40.8 12. (12.6 9. (9.8 10. (10 30. P0 P<0. 0. (0. (19 (2 (13 (40. (12. (9. (1 P<0 (0 (40 (12 (9 P< (4

Abstract: The concept of higher education is the accumulation and philosophical implication of China’s excellent traditional culture, as well as the humanistic spirit and philosophical thought with Chinese characteristics. However, the current concept of higher education has problems, such as inaccurate target positioning, emphasizing theoretical teaching, neglecting practice and being difficult to adapt to market and social needs. How to solve these problems and promote the concept of higher education to glow with new vitality in the new era is currently an urgent issue to be solved. Therefore, this article focused on traditional Chinese philosophical culture and explored the interactive relationship between traditional Chinese philosophical culture and higher education concepts. This article attempted to analyze the relationship between traditional Chinese philosophical culture and higher education concepts from the perspective of their interaction, significance and ways to achieve interaction. The study found that the interaction between traditional Chinese philosophical culture and higher education concepts is of great significance, and it was an important starting point for educational reform to demonstrate new achievements in the new era. This article hoped that the study of the interactive relationship between the two can help people better understand the concept of higher education, better grasp the significance of higher education concepts in the new era from both knowledge and behavior, and provide more theoretical basis for higher education reform. Abstract Chinas China s characteristics However positioning teaching needs solved Therefore behavior

Resumo: O conceito de ensino superior é o acúmulo e a implicação filosófica da excelente cultura tradicional da China, bem como o espírito humanístico e o pensamento filosófico com características chinesas. No entanto, o conceito atual de ensino superior tem problemas, como o posicionamento de metas imprecisas, a ênfase no ensino teórico, a negligência da prática e a dificuldade de adaptação às necessidades sociais e do mercado. Como resolver esses problemas e promover o conceito de ensino superior, para que brilhe com nova vitalidade, na nova era, é uma questão urgente a ser resolvida neste momento. Portanto, este artigo se concentrou na cultura filosófica tradicional chinesa e explorou a relação interativa entre a cultura filosófica tradicional chinesa e os conceitos de ensino superior. O texto procurou analisar a relação entre a cultura filosófica tradicional chinesa e os conceitos de ensino superior, a partir da perspectiva de sua interação, importância e formas de alcançar a interação. O estudo constatou que a interação entre a cultura filosófica tradicional chinesa e os conceitos de ensino superior é de grande importância, e foi um importante ponto de partida para a reforma educacional demonstrar novas conquistas, na nova era. Com este artigo, espera-se que o estudo da relação interativa entre ambos possa ajudar as pessoas a entenderem melhor o conceito de ensino superior, compreender melhor a importância dos conceitos de ensino superior, na nova era, tanto do ponto de vista do conhecimento quanto do comportamento, e fornecer mais base teórica para a reforma do ensino superior. Resumo China chinesas entanto imprecisas teórico mercado vitalidade era momento Portanto conquistas esperase espera comportamento

In this work, the asymmetrical rolling of 860 μm thick high-purity titanium (HP-Ti) strips is investigated. HP-Ti ultra-thin strips are produced in thicknesses ranging from 280 μm to 20 μm. The microstructure and texture evolution of HP-Ti ultra-thin strips were analyzed using electron backscattering diffraction (EBSD), transmission electron microscopy (TEM), and X-ray diffraction (XRD). The raw strips have a homogeneous and equiaxed microstructure, containing some face-centered cubic (FCC) Ti laths. With a rise in rolling reduction, equiaxed grains change into deformation structures characterized by a high density of dislocations. The formation of an ultra-fine grained microstructure and the elimination of FCC-Ti laths come next. The influence of grain rotation and slip systems on the development of texture in ultra-thin strips during rolling reduction is illustrated through the analysis of {0002} pole figures and orientation distribution function. The tensile qualities of ultra-thin strips are correlated with their microstructure. work 86 highpurity purity HPTi HP (HP-Ti investigated ultrathin ultra thin 28 2 EBSD, EBSD , (EBSD) TEM, TEM (TEM) Xray X ray XRD. XRD . (XRD) facecentered face centered FCC (FCC dislocations ultrafine fine FCCTi next 0002 {0002 function 8 (EBSD (TEM (XRD 000 {000 00 {00 0 {0 {

ABSTRACT For the classification and zoning study of crops at Jianshan Farm, data were acquired by integrating Sentinel-2 optical satellite imagery with Sentinel-1 radar satellite imagery. Different crop spectral features were extracted, and four vegetation indices (NDVI, SAVI, EVI, and NDWI) were computed to analyze the spectral differences among soybean, corn, potato, and sorghum. The UNet algorithm was employed to conduct crop zoning on the remote sensing images of Jianshan Farm from September 2020 to September 2023 for four consecutive years. An improved UNet model incorporating a channelwise attention and spatial attention module (CBAM) achieved a prediction accuracy of 100% for the 2023 image data. This represents a 12.5% improvement over the baseline UNet model. These results provide data support for research on crop classification methods. Sentinel2 Sentinel 2 Sentinel- Sentinel1 1 extracted NDVI, NDVI (NDVI SAVI EVI NDWI soybean corn potato sorghum 202 years CBAM (CBAM 100 125 12 5 12.5 methods 20 10 12.

Renal fibrosis is a common manifestation in the progression of chronic kidney disease (CKD) to kidney failure. Currently, there is no available therapy to prevent the progression of renal fibrosis. Poricoic acid A (PAA) isolated from Poria cocos shows notable antifibrotic effects. However, its potential mechanism is still unclear. This study aimed to evaluate the effects and the potential mechanisms of PAA against renal fibrosis. A mouse model of renal fibrosis was established using unilateral ureteral obstruction (UUO). We showed that PAA administration significantly alleviated renal lesions and collagen deposition in UUO mice. Mice with UUO resulted in epithelial-to-mesenchymal transition (EMT) and the activation of endoplasmic reticulum stress (ERS) in the renal tissues, while PAA treatment significantly inhibited EMT and ERS activation. Additionally, PAA markedly alleviated ERS-mediated apoptosis in UUO mice. Molecular docking results indicated that PAA stably combined to GRP78 and ATF4. In conclusion, these results demonstrated that PAA possesses a significant bioactivity against renal fibrosis and its treatment mechanism might be the inhibition of ERS-mediated apoptosis. CKD (CKD failure Currently (PAA However unclear UUO. . (UUO) mice epithelialtomesenchymal epithelial mesenchymal (EMT (ERS tissues Additionally ERSmediated mediated GRP GRP7 ATF4 ATF conclusion (UUO

ABSTRACT This study investigated the effect of yeast on the growth performance and inflammation of yellow-feathered broilers challenged with lipopolysaccharide (LPS). Four hundred and eighty-one-day-old broilers (BW 38.5±1.01 g) were randomly divided into six treatments with eight replicates of 10 birds each and fed a basal diet with or without 0.025% antibiotics and 0.05 and 0.5% yeast (Saccharomyces cerevisiae, 1.0 × 1010 cfu/g), respectively. Broilers from each replication were intra-abdominally injected with LPS (1.0 mg/kg body weight) or saline at 21, 23, 25, and 27 d of age. Samples were obtained after 3 or 12 h of the first injection (d 21) and the last injection (d 27), respectively. The results showed that LPS stimulation resulted in a significant decrease in productive performance (P<0.01) and a significant decrease in splenic index (P<0.05). Lipopolysaccharide injection caused significant (P<0.01) increase in serum α-AGP in the first hour and haptoglobin in the last 3 h (P<0.01), while other acute phase proteins were not significantly affected. All chickens fed diets supplemented with 0.5% yeast had elevated serum levels of IgA (P = 0.094) and lysozyme (P = 0.067) at 12 h of the first injection compared with those fed antibiotic diets. Lipopolysaccharide injection substantially increased the levels of cytokines in serum. A trend toward decreased levels of IL-10 (P = 0.078), transforming growth factor-beta 1 (P = 0.075), and interferon-gamma (P = 0.061) was observed in the LPS-stimulation × diet interaction. There was an LPS-stimulated × diet interaction (P<0.05) for interleukin-1beta transcript levels in the liver 12 h after repeated LPS injections. Chickens fed diets with 0.05 or 0.5% yeast tended to have higher levels of toll-like receptor 4 (P = 0.074) transcripts in the spleen at 3 h and β-defensin 1 (P = 0.065) transcripts at 12 h compared with those fed diets with antibiotics. The addition of 0.05 or 0.5% yeast alleviated the adverse effects caused by LPS injection, and this study provided a reference for the application of yeast in the broiler industry. yellowfeathered yellow feathered LPS. . (LPS) eightyonedayold eighty one day old BW 385101 38 5 01 38.5±1.0 g 0025 0 025 0.025 005 05 0.0 0.5 Saccharomyces cerevisiae 1. 101 cfu/g, cfug cfu/g , cfu cfu/g) respectively intraabdominally intra abdominally (1. mgkg mg kg weight 21 23 25 2 age 27, 27) P<0.01 P001 P (P<0.01 P<0.05. P005 P<0.05 αAGP α AGP P<0.01, affected 0.094 0094 094 0.067 0067 067 IL10 IL IL-1 0.078, 0078 0.078 078 0.078) factorbeta factor beta 0.075, 0075 0.075 075 0.075) interferongamma interferon gamma 0.061 0061 061 LPSstimulation LPSstimulated stimulated (P<0.05 interleukin1beta interleukinbeta interleukin 1beta injections tolllike toll like 0.074 0074 074 βdefensin β defensin 0.065 0065 065 industry (LPS 38510 38.5±1. 002 02 0.02 00 0. (1 P<0.0 P00 (P<0.0 0.09 009 09 0.06 006 06 IL1 IL- 007 0.07 07 3851 38.5±1 ( P<0. P0 (P<0. 385 38.5± P<0 (P<0 38.5 P< (P< 38.

ABSTRACT The aim of this review is to comprehensively assess the association between a gluten-free diet (GFD) and metabolic control of type 1 diabetes mellitus (T1DM) in children and adolescents with T1DM and with T1DM plus coeliac disease (CD). PubMed, Embase, Cochrane Library, and Web of Science were searched until June 19, 2023. Primary outcomes were hemoglobin A1c (HbA1c), insulin dose, insulin dose adjusted A1c (IDAA1c), blood glucose (B-glu) at 90 min during Mixed Meal Tolerance Test (MMTT), C-peptide area under the curve (AUC), and C-peptide. Seven studies involving 355 T1DM patients were included. Three studies involving 141 patients compared a GFD to a standard diet in children and adolescents with T1DM without CD. Additionally, two studies with 164 patients examined the same diet comparison in those with T1DM and concurrent CD. A comparison between T1DM with CD and T1DM alone, using a GFD, was conducted in two studies encompassing 50 patients. Patients with T1DM alone had similar HbA1c [pooled weighted mean difference (WMD) = −0.5, 95% confidence interval (CI): −1.0 to 0.1, P = 0.079] and IDAA1c (pooled WMD = −0.4, 95%CI: −0.9 to 0.1, P = 0.095) levels after a GFD and a standard diet. In children and adolescents with T1DM and CD, a GFD was associated with a significantly lower HbA1c compared with a standard diet (pooled WMD = −0.64, 95%CI: −1.22 to −0.05, P = 0.034). Insulin dose was significantly lower in T1DM combined with CD patients having a GFD vs a standard diet (pooled WMD = −0.34, 95%CI: −0.66 to −0.03, P = 0.032). Our study suggests that a GFD may offer significant benefits for children and adolescents with both T1DM and CD over a standard diet. While the evidence indicates improved glycemic control with a GFD, the quality of this evidence is low, highlighting the need for rigorous, randomized trials to confirm these preliminary findings. In the interim, enhancing dietary awareness and providing tailored nutritional guidance could be pivotal for optimizing glucose management in this patient population. glutenfree gluten free (GFD TDM T DM (T1DM . (CD) PubMed Embase Library 19 2023 Ac c HbA1c, HbAc , HbA (HbA1c) IDAA1c, IDAAc IDAA (IDAA1c) Bglu B glu (B-glu 9 MMTT, MMTT (MMTT) Cpeptide C peptide AUC, AUC (AUC) Cpeptide. peptide. 35 included 14 Additionally 16 5 pooled (WMD 05 0 −0.5 95 CI (CI) 10 −1. 01 0.1 0.079 0079 079 04 4 −0.4 95%CI 95CI 09 −0. 0.095 0095 095 064 64 −0.64 122 22 −1.2 005 −0.05 0.034. 0034 0.034 034 0.034) 34 −0.34 066 66 −0.6 003 03 −0.03 0.032. 0032 0.032 032 0.032) low rigorous findings interim population (CD 202 (HbA1c (IDAA1c (MMTT (AUC 3 (CI −1 0. 0.07 007 07 −0 0.09 009 06 6 12 2 00 −0.0 0.03 −0.3 20 − 0.0

Abstract Objective: To investigate the efficacy of cluster nursing intervention based on Enhanced Recovery After Surgery (ERAS) for xerostomia in chronic rhinosinusitis after nasal endoscopic surgery. Methods: A total of 80 patients with chronic rhinosinusitis who underwent functional nasal endoscopic surgery between January 2020 and December 2021 were selected and randomly divided into a control group (n = 40) and an experimental group (n = 40). Patients in the control group were treated with general nursing, while ERAS-based cluster nursing intervention was adopted for the experimental group, in addition to general nursing. Xerostomia stage and comfort level were observed at 2h, 6h, 24h and 48h after surgery; negative emotions before and after nursing were also observed. Results: After the intervention, the xerostomia stage and comfort level at 6, 24 and 48 after surgery were higher in the experimental group (p < 0.05). Negative emotions in the experimental group were lower after nursing (p < 0.001). The self-rating depression scale and self-rating anxiety scale scores increased after nursing in both two groups (p < 0.05). Conclusion: Enhanced recovery after surgery-based cluster nursing intervention can alleviate xerostomia, improve patients’ comfort levels, reduce their negative emotions and accelerate postoperative recovery. Level of evidence: 2. Objective ERAS (ERAS Methods 8 202 n 40 40. . ERASbased 2h h 6h Results 6 2 4 p 0.05. 005 0.05 0 05 0.05) 0.001. 0001 0.001 001 0.001) selfrating self rating Conclusion surgerybased levels evidence 20 00 0.0 000 0.00 0.

ABSTRACT In soybeans from different years, the infrared spectroscopy waveforms exhibit similarities, yet variations in aging time lead to significant differences in their fatty acid content. To rapidly discern the year of soybean production, this study employed ten feature extraction algorithms in conjunction with Convolutional Neural Networks (CNN) to establish models for classifying soybeans from different years (2019, 2020, and 2021). The research findings reveal the following: (1) The CNN models, after feature extraction, all demonstrated improved accuracy. Notably, the optimal models for both powdered and granulated states were the Kpca-CNN models, achieving an accuracy of 100%. The corresponding loss function values were 0.0002 and 0.0007, with processing times of 0.19 seconds and 0.20 seconds, respectively. (2) The modeling results of all models suggest that the classification accuracy of soybean powder spectral data is higher compared to soybean particle spectral data. (3) Validation of the optimal Kpca-CNN model confirmed its consistent accuracy of 100% when introducing new data or reducing the size of the training dataset. In conclusion, the fusion of near-infrared spectroscopy analysis and CNN technology is considered an effective method for classifying soybeans from different years. This method provides a practical solution for the rapid and precise determination of seed production years.