Abstract Hanyou 3015 is a new Indica hybrid of water-saving and drought-resistance rice (WDR), combining rapid maturation and high yield potential. Whole genome sequencing results show that Hanyou 3015 carries many superior alleles that could explain its drought tolerance, high water use efficiency, rapid maturation, and wide adaptability. 301 watersaving saving droughtresistance resistance WDR, WDR , (WDR) potential tolerance efficiency adaptability 30 (WDR 3

ABSTRACT Intelligent apple-harvesting robots use a staggered distribution of branches and leaves during operation, causing problems such as slow motion planning, low operational efficiency, and high path cost for multi-degrees-of-freedom (DOF) harvesting manipulators. This study presents an autonomous apple-harvesting robotic arm-hand composite system that aims to improve the operational efficiency of intelligent harvesting in dwarf anvil-planted apple orchards. The machine vision system for fruit detection uses the deep learning convolutional neural network (CNN) YOLOv7 and RGB-D camera online detection coupling technology to rapidly recognise apples. The spatial depth information of the fruit area was then extracted from the aligned depth image for precise positioning. Coordinate transformation was used to obtain the coordinates of the fruit under the coordinate system of the manipulator. Based on the informed rapid-exploration random tree (Informed-RRT*) algorithm and path-planning model, the identified target apples were harvested without collision path planning. In an apple-harvesting test, the recognition accuracy of the visual system was 89.4%, and the average time to harvest a single apple was 9.69 s, which was 4.8% faster than the mainstream general harvesting technology. Moreover, the harvesting time for a single apple was reduced by 1.7%. Thus, the proposed system enabled accurate and efficient fruit harvesting. appleharvesting operation planning multidegreesoffreedom multi degrees freedom DOF (DOF manipulators armhand arm hand anvilplanted anvil planted orchards CNN (CNN YOLOv RGBD RGB D positioning manipulator rapidexploration rapid exploration InformedRRT* InformedRRT Informed RRT* RRT (Informed-RRT* pathplanning model test 894 89 4 89.4% 969 9 69 9.6 s 48 8 4.8 Moreover 17 1 7 1.7% Thus (Informed-RRT 89.4 96 6 9. 4. 1.7 89. 1.

RESUMO Os robôs de colheita inteligente de maçãs têm uma distribuição escalonada de galhos e folhas durante a operação, o que causa problemas como o planejamento de movimentos lentos, a baixa eficiência operacional e o alto custo de trajetória dos manipuladores de colheita com vários graus de liberdade (DOF). Este artigo apresenta um sistema composto de braço-mão robótico autônomo para colheita de maçãs que visa melhorar a eficiência operacional da colheita inteligente em pomares de maçãs plantadas com anéis anões. O sistema de visão mecânica para detecção de frutas usa a rede neural convolucional de aprendizagem profunda (CNN) YOLOv7 e uma tecnologia de acoplamento de detecção on-line de câmera RGB-D para reconhecer rapidamente as maçãs. Em seguida, as informações de profundidade espacial da área da fruta são extraídas da imagem de profundidade alinhada para um posicionamento preciso. A transformação de coordenadas é usada para obter as coordenadas da fruta no sistema de coordenadas do manipulador. Com base no algoritmo de árvore aleatória de exploração rápida informada (Informed-RRT*) e no modelo de planejamento de caminho, as maçãs-alvo identificadas são colhidas sem planejamento de caminho de colisão. Em um teste de colheita de maçãs, a precisão do reconhecimento do sistema visual foi de 89,4%, e o tempo médio de colheita de uma única maçã foi de 9,69 s, 4,8% mais rápido do que a tecnologia de colheita geral convencional. Além disso, o tempo de colheita de uma única maçã foi reduzido em 1,7%. Assim, o sistema proposto permite uma colheita de frutas precisa e eficiente. operação lentos DOF. DOF . (DOF) braçomão braço mão anões CNN (CNN YOLOv online on line RGBD RGB D seguida preciso manipulador InformedRRT* InformedRRT Informed RRT* RRT (Informed-RRT* maçãsalvo alvo colisão 894 89 4 89,4% 969 9 69 9,6 s 48 8 4,8 convencional disso 17 1 7 1,7% Assim eficiente (DOF (Informed-RRT 89,4 96 6 9, 4, 1,7 89, 1,

Resumo Fundamento A fibrilação atrial (FA) é uma complicação prevalente associada à levosimendana; no entanto, permanece incerto se existem disparidades nos efeitos da levosimendana na FA não pós-operatória e pós-operatória. Objetivos Este estudo teve como objetivo avaliar o efeito da levosimendana na FA não pós-operatória e pós-operatória conduzindo uma metanálise de ensaios clínicos randomizados (ECR). Métodos PubMed, Embase, Biblioteca Cochrane e outras bases de dados foram pesquisadas. Pares de revisores identificaram ECRs que compararam levosimendana e placebo ou outras terapias, e os resultados relataram dados de eventos de FA. Foram utilizados modelos de efeitos aleatórios (com nível de significância de 5%). Resultados Foram incluídos 29 ensaios elegíveis compreendendo 6.550 participantes, onze dos quais avaliaram a incidência de FA não pós-operatória e 18 incluíram FA pós-operatória. A análise revelou que a levosimendana elevou significativamente o risco de FA no grupo não pós-operatório (OR, 1,62; IC 95%: 1,19-2,20; p=0,002) e reduziu a incidência de FA no grupo pós-operatório (OR, 0,65; IC 95%: 0,44-0,96; p=0,03). A ocorrência de FA diminuiu mais significativamente em pacientes que usaram levosimendana após cirurgia cardíaca (OR, 0,53; IC 95%: 0,32-0,88; p=0,02) do que em pacientes que usaram levosimendana antes da cirurgia cardíaca (OR, 0,67; IC 95%: 0,42-1,06; p=0,09). O risco de FA foi significativamente elevado pela grande dose em bolus de levosimendana (dose em bolus ≥12 μg/kg) (OR, 1,44; IC 95%: 1,10-1,88; p=0,004) e diminuído pela pequena dose em bolus de levosimendana (dose em bolus <12 μg/kg) (OR, 0,64; IC 95%: 0,34-1,20; p=0,16). Conclusão A levosimendana foi associada a um aumento da incidência de FA não pós-operatória. O emprego da levosimendana foi eficaz na prevenção da FA pós-operatória. (FA entanto pósoperatória pós operatória pósoperatória. operatória. ECR. ECR . (ECR) PubMed Embase pesquisadas terapias com 5%. 5 5% 5%) 2 6550 6 550 6.55 participantes 1 pósoperatório operatório OR, OR (OR 1,62 162 62 95% 95 1,192,20 119220 1,19 2,20 19 20 1,19-2,20 p=0,002 p0002 p 0 002 0,65 065 65 0,440,96 044096 0,44 0,96 44 96 0,44-0,96 p=0,03. p003 p=0,03 03 p=0,03) 0,53 053 53 0,320,88 032088 0,32 0,88 32 88 0,32-0,88 p=0,02 p002 02 0,67 067 67 0,421,06 042106 0,42 1,06 42 06 0,42-1,06 p=0,09. p009 p=0,09 09 p=0,09) 12 ≥1 μg/kg μgkg μg kg 1,44 144 1,101,88 110188 1,10 1,88 10 1,10-1,88 p=0,004 p0004 004 <1 0,64 064 64 0,341,20 034120 0,34 1,20 34 0,34-1,20 p=0,16. p016 p=0,16 16 p=0,16) (ECR 655 55 6.5 1,6 9 192 1,192,2 11922 119 1,1 220 2,2 1,19-2,2 p=0,00 p000 00 0,6 440 0,440,9 04409 044 0,4 096 0,9 4 0,44-0,9 p00 p=0,0 0,5 05 320 0,320,8 03208 032 0,3 088 0,8 3 8 0,32-0,8 421 0,421,0 04210 042 106 1,0 0,42-1,0 ≥ 1,4 14 101 1,101,8 11018 110 188 1,8 1,10-1,8 < 341 0,341,2 03412 034 120 1,2 0,34-1,2 p01 p=0,1 6. 1, 1,192, 1192 11 22 2, 1,19-2, 0, 0,440, 0440 04 0,44-0, p0 p=0, 0,320, 0320 08 0,32-0, 0,421, 0421 0,42-1, 1,101, 1101 1,10-1, 0,341, 0341 0,34-1, 1,192 1,19-2 0,440 0,44-0 p=0 0,320 0,32-0 0,421 0,42-1 1,101 1,10-1 0,341 0,34-1 1,19- 0,44- p= 0,32- 0,42- 1,10- 0,34-

Abstract Background Atrial fibrillation (AF) is a prevalent complication associated with levosimendan; however, it remains uncertain whether there are any disparities in the effects of levosimendan on non-postoperative and postoperative AF. Objectives This study aimed to evaluate the levosimendan effect on non-postoperative and postoperative AF by conducting a meta-analysis of randomized control trials (RCTs). Methods PubMed, Embase, Cochrane Library, and other databases were searched. Pairs of reviewers identified RCTs that compared levosimendan and placebo or other therapies, and the results reported AF events data. Random effects models were used (at a significance level of 5%). Results Twenty-nine eligible trials comprising 6550 participants were included, eleven of which evaluated the non-postoperative AF incidence, and 18 included postoperative AF. The analysis revealed that levosimendan elevated the AF risk significantly in the non-postoperative group (OR, 1.62; 95% CI: 1.19-2.20; p=0.002) and reduced the AF incidence in the postoperative group (OR, 0.65; 95% CI: 0.44-0.96; p=0.03). AF occurrence decreased more significantly in patients who used levosimendan after cardiac surgery (OR, 0.53; 95% CI: 0.32-0.88; p=0.02) than in patients who used levosimendan before cardiac surgery (OR, 0.67; 95% CI: 0.42-1.06; p=0.09). Moreover, The AF risk was significantly elevated by levosimendan large bolus dose (bolus dose≥12 μg/kg) (OR, 1.44; 95% CI: 1.10-1.88; p=0.004) and decreased by small bolus dose of levosimendan (bolus dose<12 μg/kg) (OR, 0.64; 95% CI: 0.34-1.20; p=0.16). Conclusion Levosimendan was linked to an increased non-postoperative AF incidence. The employment of levosimendan was effective in preventing postoperative AF. (AF however nonpostoperative non metaanalysis meta RCTs. . (RCTs) PubMed Embase Library searched therapies data at 5%. 5 5% 5%) Twentynine Twenty nine 655 1 OR, OR (OR 1.62 162 62 95 CI 1.192.20 119220 1.19 2.20 19 2 20 1.19-2.20 p=0.002 p0002 p 0 002 0.65 065 65 0.440.96 044096 0.44 0.96 44 96 0.44-0.96 p=0.03. p003 p=0.03 03 p=0.03) 0.53 053 53 0.320.88 032088 0.32 0.88 32 88 0.32-0.88 p=0.02 p002 02 0.67 067 67 0.421.06 042106 0.42 1.06 42 06 0.42-1.06 p=0.09. p009 p=0.09 09 p=0.09) Moreover dose12 12 dose≥1 μg/kg μgkg μg kg 1.44 144 1.101.88 110188 1.10 1.88 10 1.10-1.88 p=0.004 p0004 004 dose<1 0.64 064 64 0.341.20 034120 0.34 1.20 34 0.34-1.20 p=0.16. p016 p=0.16 16 p=0.16) (RCTs 1.6 6 9 192 1.192.2 11922 119 1.1 220 2.2 1.19-2.2 p=0.00 p000 00 0.6 440 0.440.9 04409 044 0.4 096 0.9 4 0.44-0.9 p00 p=0.0 0.5 05 320 0.320.8 03208 032 0.3 088 0.8 3 8 0.32-0.8 421 0.421.0 04210 042 106 1.0 0.42-1.0 dose1 dose≥ 1.4 14 101 1.101.8 11018 110 188 1.8 1.10-1.8 dose< 341 0.341.2 03412 034 120 1.2 0.34-1.2 p01 p=0.1 1. 1.192. 1192 11 22 2. 1.19-2. 0. 0.440. 0440 04 0.44-0. p0 p=0. 0.320. 0320 08 0.32-0. 0.421. 0421 0.42-1. 1.101. 1101 1.10-1. 0.341. 0341 0.34-1. 1.192 1.19-2 0.440 0.44-0 p=0 0.320 0.32-0 0.421 0.42-1 1.101 1.10-1 0.341 0.34-1 1.19- 0.44- p= 0.32- 0.42- 1.10- 0.34-

Abstract Introduction: nutritional status and platelet-to-lymphocyte ratio (PLR) have been found to be associated with prognosis in patients with hepatocellular carcinoma (HCC) undergoing transcatheter arterial chemoembolization (TACE). Objectives: to evaluate the association between nutritional status and PLR in patients with HCC undergoing TACE. Methods: a total of 152 HCC patients received TACE were enrolled. The nutritional status was evaluated by Patient-Generated Subjective Global Assessment (PG-SGA). Patients with PG-SGA A and PG-SGA (B or C) were classified as the well-nourished and malnourished groups. Results: according to the PG-SGA, 130 (85.5 %) patients were malnourished. The median PLR was significantly different between well-nourished and malnourished groups (p = 0.008). A positive correlation was found between PLR and PG-SGA score (r = -0.265, p = 0.001). The optimal PLR cutoff value was 102.165 to predict malnutrition, with a sensitivity of 65.4 %, specificity of 72.7 %, and an area under the curve (AUC) of 0.677 (95 % confidence interval (CI): 0.550-0.804; p = 0.008). A logistic stepwise regression model showed that the PLR was associated with nutritional status in Model 1 without adjustment, as well as if adjusted by age, sex, type of TACE (c-TACE/DEB-TACE) and Child–Pugh stage (odds ratio, 0.190; 95 % CI: 0.062-0.582; p = 0.004). Conclusions: nutritional status measured by PG-SGA was significantly associated with PLR in patients with HCC undergoing TACE.

Resumen Introducción: se ha encontrado que el estado nutricional y el índice plaquetas-linfocitos (PLR) se asocian con el pronóstico en pacientes con carcinoma hepatocelular (CHC) sometidos a quimioembolización transarterial (TACE). Objetivos: evaluar la asociación entre el estado nutricional y la PLR en pacientes con CHC sometidos a TACE. Métodos: se evaluaron 152 pacientes con CHC que recibieron TACE. El estado nutricional fue evaluado por Evaluación Global Subjetiva Generada por el Paciente (PG-SGA). Los pacientes con PG-SGA A y PG-SGA (B o C) se clasificaron como los grupos bien nutridos y desnutridos. Resultados: según la PG-SGA, 130 (85,5 %) pacientes estaban desnutridos. La mediana de PLR fue significativamente diferente entre los grupos bien nutridos y desnutridos (p = 0,008). Se encontró una correlación positiva entre PLR y la puntuación PG-SGA (r = -0,265, p = 0,001). El valor de corte óptimo de PLR fue de 102,165 para predecir la malnutrición, con una sensibilidad del 65,4 %, una especificidad del 72,7 % y un área bajo la curva (AUC) de 0,677 (intervalo de confianza [IC] del 95 %: 0,550-0,804; p = 0,008). Un modelo de regresión logística escalonada mostró que el PLR se asoció con el estado nutricional en el Modelo 1 sin ajuste, así como cuando se ajustó por edad, sexo, tipo de TACE (c-TACE/DEB-TACE) y etapa Child-Pugh (odds ratio, 0,190; IC 95 %: 0,062-0,582; p = 0,004). Conclusiones: el estado nutricional medido por PG-SGA se asoció significativamente con PLR en pacientes con CHC sometidos a TACE.

Abstract Background stewart-treves syndrome (STS) is an angiosarcoma associated with chronic lymphedema. Objectives This article analyses the characteristics of twenty-two patients and proposes active intervention in lymphedema and the early diagnosis of STS. Methods Twenty-two patients with STS were diagnosed at the centre over an 11-year period. Clinical manifestations, a series of conventional analyses, and histopathology were used to study these cases retrospectively. Results The age range of 22 patients with STS was 15 to 78 years. The main clinical manifestations included multiple skin and subcutaneous nodules and scattered red or purplish-red rashes in the lymphoedematous limbs. These patients often showed clinical symptoms such as lymphedema, weakness, emaciation, pain, mass, lymphadenopathy and so on. The positive rates of ultrasonography, MRI and radionuclide imaging were 66.7% (6/9), 92.3% (12/13) and 18.2% (2/11), respectively. The main points regarding active intervention in lymphedema and early diagnosis of STS were summarized. Study limitations Since this was a retrospective study, the main points summarized by the author need to be further quantified in clinical work to guide the diagnosis of this kind of disease more conveniently. In addition, further clinical trials are needed to evaluate the role of lymphedema in the occurrence and development of malignant tumors. Conclusions STS can appear in lymphoedematous tissue many years after lymphedema onset. To avoid delays in the diagnosis and therapy of STS, physicians should actively look for signs or symptoms of malignant lymphedema during the follow-up period and promptly manage patients developing problems. stewarttreves stewart treves (STS twentytwo twenty two Twentytwo Twenty 11year year 11 retrospectively 2 1 7 purplishred purplish limbs weakness emaciation pain mass on ultrasonography 667 66 66.7 6/9, 69 6/9 , 6 9 (6/9) 923 92 3 92.3 12/13 1213 12 13 (12/13 182 18 18.2 2/11, 211 2/11 (2/11) respectively conveniently addition tumors onset followup follow up problems 66. 6/ (6/9 92. 12/1 121 (12/1 18. 21 2/1 (2/11 (6/ 12/ (12/ 2/ (2/1 (6 (12 (2/ ( (1 (2

OBJECTIVE: Heart failure is a progressive and debilitating disease. Intracoronary sarcoplasmic reticulum calcium-ATPase gene therapy may improve the function of cardiac muscle cells. This study aimed to test the hypothesis that intracoronary sarcoplasmic reticulum calcium-ATPase gene therapy can improve outcomes and reduce the number of recurrent and terminal events in advanced heart failure patients with reduced ejection fraction. METHODS: A total of 768 heart failure patients with reduced ejection fraction and New York Heart Association classification II to IV were included in this prospective cohort study. Patients either underwent intracoronary sarcoplasmic reticulum calcium-ATPase gene therapy (CA group, n=384) or received oral placebo (PA group; n=384). Data regarding recurrent and terminal event(s), treatment-emergent adverse effects, and outcome measures were collected and analyzed. RESULTS: After a follow-up period of 18 months, intracoronary sarcoplasmic reticulum calcium-ATPase gene therapy reduced the number of hospital admissions (p=0.001), ambulatory treatments (p=0.0004), and deaths (p=0.024). Additionally, intracoronary sarcoplasmic reticulum calcium-ATPase gene therapy improved the left ventricular ejection fraction (p<0.0001) and Kansas City Cardiomyopathy Questionnaire score (p<0.0001). The number of recurrent and terminal events/patients were higher in the PA group than in the CA group after the follow-up period of 18 months (p=0.015). The effect of the intracoronary sarcoplasmic reticulum calcium-ATPase gene therapy was independent of the confounding variables. No new arrhythmias were reported in the CA group. CONCLUSIONS: Intracoronary sarcoplasmic reticulum calcium-ATPase gene therapy reduces the number of recurrent and terminal events and improves the clinical course of advanced heart failure patients with reduced ejection fraction.

ABSTRACT To increase rice yield potential, field experiments were conducted in farmers’ paddies in 2011 and 2012 to evaluate the effects of different nitrogen applications on the yield and panicle components of three typical indica hybrid rice varieties in Sichuan Province. The number of grains per panicle resulting from late nitrogen application (LA) was 12 % greater than that obtained from traditional nitrogen application (TA); this increase was the main source of improvements in yield. The number of surviving and differentiated spikelets (NSS and NDiS) resulting from LA was significantly higher than that measured under TA, especially for the Fyou498 cultivar, where the NSS and NDiS increased by 15 % and 14 %, respectively. Compared with TA, the number of degenerated secondary branches and the percentage of degenerated secondary branches (NDeSB and PDeSB) were significantly reduced by 9 % and 11 %, respectively, by LA. This is the first study to demonstrate that an increase in NSS and a decrease in NDeSB lead to yield-improving effects attributable to LA. The grain yields of different varieties ranged from 9225.6 to 9408.7 kg ha−1, the PDeSB was as high as 31 %, and the number of surviving secondary branches (NSSB) was significantly and positively correlated with NSS. These data indicate that the yield of indica hybrid rice has considerable potential for being improved, and increasing NSSB is key to increasing NSS and improving the grain yield. These improvements should be pursued so as to increase the yield of hybrid rice to ensure both food security and sustainable agricultural development.

Our objective was to evaluate the association of rs12255372 in theTCF7L2 gene with type 2 diabetes mellitus (T2DM) in the world population. We carried out a survey of the literature about the effect of rs12255372 on genetic susceptibility to T2DM by consulting PubMed, the Cochrane Library, and Embase from 2006 to 2012, and then performed a meta-analysis of all the studies in order to evaluate the association between rs12255372 and T2DM. A total of 33 articles including 42 studies (with 34,076 cases and 36,192 controls) were confirmed to be eligible and were included in the final meta-analysis: 6 studies conducted on Europeans, 14 on Caucasians, 17 on Asians, 2 on Africans, and 3 on Americans. Overall, the effect size was as follows: for the variant allele T (OR = 1.387, 95%CI = 1.351-1.424), for the TT genotype (OR = 1.933, 95%CI = 1.815-2.057), for the GT genotype (OR = 1.363, 95%CI = 1.315-1.413), for the dominant model (OR = 1.425, 95%CI = 1.344-1.510), and for the recessive model (OR = 1.659, 95%CI = 1.563-1.761). In summary, by pooling all available qualified data from genetic studies on rs12255372 and T2DM, we have confirmed that rs12255372 is significantly associated with susceptibility to T2DM in the global population.