Abstract Objective: Signs and symptoms of osteomyelitis or septic arthritis in neonates and infants are often nonspecific and early-stage bone infections in infants may often go unnoticed. The objective of this study was to analyze the clinical characteristics of newborns and infants with osteomyelitis and septic arthritis to improve understanding of the disorder and to assist clinicians with diagnosis. Methods: A retrospective multicenter study was conducted on neonates (0-28 days old, n = 94) and infants (1–12 months old, n = 415) with osteoarticular infections. Data consisting of clinical characteristics, complications, laboratory outcomes, and the pathogenic microorganisms causing osteomyelitis were tabulated. The statistics were further broken down into two regions and the significant differences between neonates and infants were evaluated and compared to the literature. Results: Compared to infants, neonates had significantly lower incidences of fever (p < 0.0001), higher incidences of localized swelling (p = 0.0021), higher rate of infection at the humerus (p = 0.0016), higher percentage of Escherichia coli (p < 0.0001) and Klebsiella pneumoniae (p = 0.0039) infections, lower percentage of Staphylococcus aureus infections (p < 0.0001) and were more likely to develop septic arthritis (p < 0.0001). Conclusion: Distinct differences were found between neonatal and infants with osteoarticular infections. Future studies should focus on improving diagnosis and subsequent treatment regimens for younger age groups. Objective earlystage early stage unnoticed Methods 028 0 28 (0-2 old 94 1–12 112 1 12 (1–1 415 complications outcomes tabulated literature Results p 0.0001, 00001 0.0001 , 0001 0.0021, 00021 0.0021 0021 0.0021) 0.0016, 00016 0.0016 0016 0.0016) 0.0039 00039 0039 0.0001. . Conclusion groups 02 2 (0- 9 1–1 11 (1– 41 0000 0.000 000 0002 0.002 002 0.001 001 0.003 0003 003 (0 1– (1 4 0.00 00 ( 0.0 0.

ABSTRACT Objective: To evaluate objective treatment efficacy and safety, and subjective patient-reported outcomes in patients with complex ureteral strictures (US) undergoing minimally invasive lingual mucosal graft ureteroplasty (LMGU). Materials and Methods: We prospectively enrolled patients underwent robotic or laparoscopic LMGU between May 2020 and July 2022. Clinical success was defined as symptom-free and no radiographic evidence of re-obstruction. Patient-reported outcomes, including health-related quality of life (HRQoL), mental health status and oral health-related quality of life (OHRQoL), were longitudinally evaluated before surgery, 6 and 12 months postoperatively. Results: Overall, 41 consecutive patients were included. All procedures were performed successfully with 32 patients in robotic approach and 9 in laparoscopic. Forty (97.56%) patients achieved clinical success during the median follow-up of 29 (range 15-41) months. Although patients with complex US experienced poor baseline HRQoL, there was a remarkable improvement following LMGU. Specifically, the 6-month and 12-month postoperative scores were significantly improved compared to the baseline (p < 0.05) in most domains. Twenty-eight (68.3%) and 31 (75.6%) patients had anxiety and depression symptoms before surgery, respectively. However, no significant decrease in the incidence of these symptoms was observed postoperatively. Moreover, there was no significant deterioration of OHRQoL at 6 months and 12 months postoperatively when compared to the baseline. Conclusions: LMGU is a safe and efficient procedure for complex ureteral reconstruction that significantly improves patient-reported HRQoL without compromising OHRQoL. Assessing patients’ quality of life enables us to monitor postoperative recovery and progress, which should be considered as one of the criteria for surgical success. Objective safety patientreported patient reported (US . (LMGU) Methods 202 2022 symptomfree symptom free reobstruction. reobstruction re obstruction. obstruction re-obstruction Patientreported Patient healthrelated related , (HRQoL) OHRQoL, (OHRQoL) surgery 1 Results Overall 4 included 3 97.56% 9756 97 56 (97.56% followup follow up 2 range 1541 15 15-41 Specifically 6month month 12month p 0.05 005 0 05 domains Twentyeight Twenty eight 68.3% 683 68 (68.3% 75.6% 756 75 (75.6% respectively However Moreover Conclusions progress (LMGU 20 (HRQoL (OHRQoL 97.56 975 5 (97.56 154 15-4 0.0 00 68.3 (68.3 75.6 7 (75.6 97.5 (97.5 15- 0. 68. (68. 75. (75. 97. (97. (68 (75 (97 (6 (7 (9 (

RESUMO: A lesão hepática aguda (ALI) é um problema médico importante que requer terapia eficaz. A astaxantina (AST) é um carotenóide, e os efeitos benéficos da astaxantina, incluindo atividades antioxidantes, anti-inflamatórias e antitumorais, foram identificados. O presente estudo foi desenhado para elucidar os efeitos protetores da astaxantina contra ALI e seus mecanismos subjacentes. Macrófagos RAW264.7 foram tratados com dimetil sulfóxido combinado com diferentes doses de astaxantina por 12 h. Os camundongos foram alimentados com ou sem astaxantina por até sete dias. O LPS foi administrado para induzir a inflamação. Histopatologia, estresse oxidativo, inflamação e apoptose foram avaliados. Os resultados indicaram que a astaxantina atenuou o estresse oxidativo induzido por LPS, inflamação e apoptose celular in vivo e in vitro. Experimentos in vivo e in vitro mostraram que a astaxantina regulou negativamente as vias de sinalização do fator nuclear-kappa beta (NF-κB), fator nuclear 2 relacionado ao eritróide 2 (Nrf2) e domínio de pirina da família NLR contendo 3 (NLRP3), inibindo o LPS- resposta inflamatória induzida, estresse oxidativo e apoptose celular e alívio da ALI induzida por LPS em camundongos. RESUMO (ALI eficaz AST (AST carotenóide antioxidantes antiinflamatórias anti inflamatórias antitumorais identificados subjacentes RAW2647 RAW RAW264 7 RAW264. 1 h dias Histopatologia avaliados nuclearkappa kappa NFκB, NFκB NF κB , (NF-κB) Nrf2 Nrf (Nrf2 NLRP3, NLRP3 NLRP (NLRP3) RAW26 (NF-κB (Nrf (NLRP3 RAW2 (NLRP

ABSTRACT: Acute liver injury (ALI) is an important medical problem that requires effective therapy. Astaxanthin (AST) is a carotenoid, and the beneficial effects of astaxanthin, including anti-oxidative, anti-inflammatory and anti-tumour activities, have been identified. The present study was designed to elucidate the protective effects of astaxanthin against ALI and their underlying mechanisms. RAW264.7 macrophages were treated with dimethyl sulfoxide combined with different doses of astaxanthin for 12 h. Mice were fed with or without astaxanthin for up to 7 days. LPS was administered to induce inflammation. We assessed histopathology, oxidative stress, inflammation and apoptosis .The results indicated that astaxanthin attenuated LPS-induced oxidative stress, inflammation and cell apoptosis both in vivo and in vitro. In vivo and in vitro experiments showed that astaxanthin down regulated the nuclear factor-kappa beta (NF-κB), nuclear factor erythroid 2-related factor 2 (Nrf2) and NLR family pyrin domain containing 3 (NLRP3) signalling pathways, inhibiting the LPS-induced inflammatory response, oxidative stress and cell apoptosis, and alleviating LPS-induced ALI in mice. ABSTRACT (ALI therapy AST (AST carotenoid antioxidative, antioxidative anti oxidative, anti-oxidative antiinflammatory antitumour tumour activities identified mechanisms RAW2647 RAW RAW264 RAW264. 1 h days histopathology LPSinduced induced factorkappa kappa NFκB, NFκB NF κB , (NF-κB) 2related related Nrf2 Nrf (Nrf2 NLRP3 NLRP (NLRP3 pathways response mice RAW26 (NF-κB (Nrf (NLRP RAW2

ABSTRACT This research aims to investigate the microstructure evolution and related mechanical properties of Mg-9.5Gd-0.8Zn-0.5Zr alloys with different Y contents (x = 0, 1, 2, and 3wt%). The effects of different heat treatment conditions on these alloys were investigated. The results show that the initial microstructure of the as-cast alloy without Y is composed of α-Mg matrix and Mg5Gd phase. Additional phases such as Mg24(Gd,Y)5 and Mg24Y5 appeared with the increase of Y content. After homogenization treatment, these phases are transformed into high temperature stable 14H-LPSO phase. It is noteworthy that the precipitation of the β′ phases in peak-aged alloys significantly enhances the strength, while the addition of Y enhances the plasticity. The peak-aged Mg-9.5Gd-0.8Zn-0.5Zr-2Y alloy exhibits the best mechanical properties, and the ultimate tensile strength, yield strength and elongation are 313MPa, 211MPa and 6.51%, respectively. Mg9.5Gd0.8Zn0.5Zr Mg95Gd08Zn05Zr MgGdZnZr Mg 9.5Gd 0.8Zn 0.5Zr 9 5Gd 0 8Zn 5Zr Gd Zn Zr x 1 2 3wt%. 3wt wt 3wt% . 3wt%) investigated ascast cast αMg α MgGd phase Mg24Gd,Y5 Mg24GdY5 MgGdY Mg24 Gd,Y 5 Mg24(Gd,Y) MgY Mg24Y content 14HLPSO HLPSO 14H LPSO H β peakaged peak aged plasticity Mg9.5Gd0.8Zn0.5Zr2Y Mg95Gd08Zn05Zr2Y MgGdZnZrY 2Y 313MPa MPa 651 6 51 6.51% respectively Mg9 5Gd0 8Zn0 95Gd 08Zn 05Zr Mg24Gd Y5 Mg24Gd,Y GdY Mg24GdY Mg2 Mg24(Gd,Y 5Zr2Y 65 6.51 ZrY 6.5 6.

Abstract The results of finite element analysis of reinforced concrete Vierendeel sandwich plates (RCVSP) using beam-plate elements calculation model show a significant discrepancy with the actual results. Considering the structural characteristics of RCVSP and the calculation method of beam-elements, the assumption of the existence of nodal stiffness domain effects (NSDE) is proposed for its beam-plate elements calculation model. In order to verify this assumption, the existing experimental data of RCVSP is used to compare with the finite element analysis results of the beam-plate elements calculation model. The analysis results show that there is NSDE in the finite element analysis of RCVSP using beam-plate elements calculation model. The beam-elements calculation model FeaR1, which fully considers NSDE, can effectively restore the calculated stiffness lost. Compared with the solid-elements calculation model of RCVSP, the calculation model FeaR1 is more convenient for modeling, enhances computational efficiency, achieves the stiffness restoration rate of approximately 80%, and maintains the average error of no more than 16%. (RCVSP beamplate beam plate beamelements, beamelements elements, (NSDE FeaR lost solidelements solid modeling efficiency 80 80% 16 16% 8 1

Abstract Objective: This study investigated the effects of N-Acetylcysteine (NAC) combined with Ambroxol Hydrochloride (AH) on clinical symptoms, C-Reactive Protein (CRP), and Procalcitonin (PCT) levels in children with pneumonia. Methods: A total of 98 children with pneumonia were assigned to the control group and observation group by random number table method. NAC was administered to the observation group and AH was given to the control group. The therapeutic effect was observed, the disappearance time of clinical symptoms and levels of inflammatory factors, lung function parameters, blood gas analysis parameters, and immunoglobulin were measured. The incidence of adverse reactions was statistically analyzed. Results: A higher effective rate was observed in the observation group than in the control group (p < 0.05). Antipyretic time, cough disappearance time, and lung rale disappearance time in the observation group were shorter than those in the control group (p < 0.05). After treatment, CRP and PCT were lower (p < 0.05), FVC, FEV1, and FEV1/FVC were higher, PaCO2 was lower, PaO2 and SaO2 were higher, and IgA, IgG, IgM, and C3 were higher in the observation group than those in the control group (p < 0.05). The incidence of adverse reactions between the two groups was not significantly different (p > 0.05). Conclusion: NAC combined with AH is effective in the treatment of pediatric pneumonia by effectively alleviating clinical symptoms, reducing inflammatory factors, and improving lung function and immune function. Objective NAcetylcysteine N Acetylcysteine (NAC (AH CReactive C Reactive CRP, , (CRP) (PCT Methods 9 method factors parameters measured analyzed Results p 0.05. 005 0.05 . 0 05 0.05) 0.05, FVC FEV1 FEV FEV1FVC FEVFVC PaCO PaO SaO IgA IgG IgM Conclusion (CRP 00 0.0 0.

ABSTRACT Under the conservation tillage model, corn stubble with a complex structure has become the main obstacle for the operation of tillage tools. To better design relevant tillage tools as a reference, this study established a discrete element model of corn stubble. The intrinsic parameters and partial contact parameters of corn single root (CSR) were obtained through physical experiments, and the maximum shear force (Fmax) of CSR was tested. Fmax was used as the response value, Plackett-Burman test, steepest climbing test, and Box-Behnken test were used to determine the optimal parameters of the discrete element model. The results showed that the coefficient of friction of CSR-CSR, the coefficient of friction of CSR-steel, and the bonded disk radius all had significant effects on Fmax (P<0.01). The optimal solution is when they are 0.81, 0.76, and 0.93 mm respectively. Under this condition, the relative error of Fmax between the simulation and the fitting equation was 2.85%. In addition, shear validation tests were conducted on CSR with different diameters. Finally, based on the actual size of the corn stubble, a discrete element model of the entire corn stubble was established, which can provide a reference for studying the crushing of corn stubble. (CSR experiments (Fmax tested value PlackettBurman Plackett Burman BoxBehnken Box Behnken CSRCSR, CSRCSR CSR, CSR-CSR CSRsteel, CSRsteel steel, steel CSR-steel P<0.01. P001 P P<0.01 . 0 01 (P<0.01) 081 81 0.81 076 76 0.76 093 93 0.9 respectively condition 285 2 85 2.85% addition diameters Finally P00 P<0.0 (P<0.01 08 8 0.8 07 7 0.7 09 9 0. 28 2.85 P0 P<0. (P<0.0 2.8 P<0 (P<0. 2. P< (P<0 (P< (P

Abstract Objective: Chronic Rhinosinusitis with Polyps (CRSwNP) is characterized by high heterogeneity and postoperative recurrence rate. This study aims to explore the clinical significance of tissue Leukocyte-Specific Transcript 1 (LST1) in predicting CRSwNP recurrence. Methods: We enrolled 62 CRSwNP patients including 30 primary CRSwNP and 32 recurrent CRSwNP patients, and 40 Healthy Controls (HC). Tissue samples were collected. Tissue LST1 expression was assessed by Reverse Transcription-Polymerase Chain Reaction (RT-PCR), Western Blotting (WB) and Immunofluorescence (IF) staining. The predictive values of LST1 expression for CRSwNP postoperative recurrence were assessed through the Receiver Operating Characteristic (ROC) curves. Results: The tissue levels of LST1 were significantly increased in the CRSwNP group than the HC group, especially in the recurrent group, and the elevated LST1 mRNA levels were positively correlated with the peripheral eosinophil percentages, tissue eosinophil counts and percentages. IF staining results showed that the LST1 protein levels were higher in CRSwNP patients, especially in the recurrent patients than in the HC group. ROC curves highlighted that tissue LST1 levels were associated with recurrent CRSwNP and exhibited a higher predictive ability for postoperative CRSwNP recurrence. Conclusion: This was the first report suggesting that LST1 expression was upregulated and associated with mucosal eosinophil infiltration and CRSwNP recurrence. Tissue LST1 could be a promising biomarker for predicting postoperative recurrence in CRwNP patients. Objective (CRSwNP rate LeukocyteSpecific Leukocyte Specific LST (LST1 Methods 6 3 4 HC. . (HC) collected TranscriptionPolymerase Transcription Polymerase RTPCR, RTPCR RT PCR , (RT-PCR) WB (WB (IF (ROC Results percentages Conclusion (LST (HC (RT-PCR

Abstract Objective: To investigate the optimal timing of initial intravenous immunoglobulin (IVIG) treatment in Kawasaki disease (KD) patients. Methods: KD patients were classified as the early group (day 1-4), conventional group (day 5-7), conventional group (day 8-10), and late group (after day 10). Differences among the groups were analyzed by ANOVA and Chi-square analysis. Predictors of IVIG resistance and the optimal cut-off value were determined by multiple logistic regression analyses and receiver operating characteristic (ROC) curve analysis. Results: There were no significant differences in IVIG resistance among the 4 groups (p = 0.335). The sensitivity analysis also confirmed no difference in the IVIG resistance between those who started the initial IVIG ≤ day 7 of illness and those who received IVIG >day 7 of illness (p = 0.761). In addition, patients who received IVIG administration more than 7 days from the onset had a higher proportion of coronary artery abnormalities (p = 0.034) and longer length of hospitalization (p = 0.033) than those who started IVIG administration less than 7 days. The optimal cut-off value of initial IVIG administration time for predicting IVIG resistance was >7 days, with a sensitivity of 75.25% and specificity of 82.41%. Conclusions: IVIG therapy within 7 days of illness is found to be more effective for reducing the risk of coronary artery abnormalities than those who received IVIG >day 7 of illness. IVIG treatment within the 7 days of illness seems to be the optimal therapeutic window of IVIG. However, further prospective studies with long-term follow-up are required. Objective (IVIG (KD Methods 14, 14 1 , 1-4) 57, 57 5 5-7) 810, 810 8 10 8-10) after 10. . 10) Chisquare Chi square cutoff cut off ROC (ROC Results p 0.335. 0335 0.335 0 335 0.335) 0.761. 0761 0.761 761 0.761) addition 0.034 0034 034 0.033 0033 033 > 7525 75 25 75.25 8241 82 41 82.41% Conclusions However longterm long term followup follow up required 1-4 5-7 81 8-10 0.33 33 076 0.76 76 0.03 003 03 752 2 75.2 824 82.41 1- 5- 8-1 0.3 3 07 0.7 0.0 00 75. 82.4 8- 0. 82.

Abstract Objectives: Lung cancer was one of the most common malignancies around the world. It has great significance in to search for the mechanism of occurrence and development of lung cancer. LIM Domain Binding protein 2 (LDB2) belongs to the LIM-domain binding family, it can be used as a binding protein that combined with other transcription factors to form the transcription complex for regulating the expression of target genes. The expression of microRNA-96-5p (miR-96-5p) has been investigated in various tumors. The aim of this study is to investigate the potential role of LDB2 and miR-96-5p in lung cancer. Methods: Real-time quantitative PCR was applied to detect the expression of LDB2 and miR-96-5p. The proliferation, invasion, and metastasis of H1299 cells were analyzed by CCK8, transwell, and wound healing assay after LDB2 or miR-96-5p transfection. Luciferase activities assay and western blot were used to reveal the targeted regulation between LDB2 and miR-96-5p. Results: Here the authors found LDB2 was down-regulated in lung cancer tissues and negatively correlated with miR-96-5p expression, it could promote or inhibit the proliferation, invasion and metastasis of H1299 cells after LDB2 knockdown or overexpression and regulate the expression of cyclinD1, MMP9, Bcl-2, and Bax via ERK1/2 signaling pathway. Furthermore, miR-96-5p exerted its function by directly binding to 3′-UTR of LDB2 and regulating expression of LDB2. miR-96-5p could promote the proliferation, invasion, and metastasis of H1299 cells. Conclusion: These findings demonstrate that LDB2 can act as a new regulator to inhibit cell proliferation, invasion, and metastasis via the ERK1/2 signaling pathway, and miR-96-5p may be a potential promising molecular by targeting LDB2 in lung cancer. Objectives world LDB (LDB2 LIMdomain domain family genes microRNA965p microRNAp microRNA 96 5p p miR965p miRp miR (miR-96-5p tumors Methods Realtime Real time miR965p. 5p. proliferation H H129 CCK8 CCK transwell transfection Results downregulated down regulated cyclinD1 cyclinD MMP9 MMP Bcl2, Bcl2 Bcl 2, Bcl-2 ERK12 ERK ERK1 ERK1/ pathway Furthermore 3′UTR 3UTR UTR 3′ 3 Conclusion (LDB 9 H12 Bcl- H1

Abstract This study aimed to investigate the effects of eugenol (Eu) at different concentrations (0, 10, 50, 100, 200, and 300 μM/g protein) on the gel properties and chemical structure changes of porcine myofibrillar protein (MP). The results showed that Eu inhibited the increase of surface hydrophobicity and carbonyl content but did not prevent the oxidation-induced loss of thiol groups. Moreover, Eu intensified the loss of the α-helical conformation as well as the tertiary structure of MP under oxidative stress. The physicochemical changes at 10 and 50 μM/g Eu resulted in a significant enhancement of the gelling ability of MP and enhanced the positive role of oxidation in building elastic gel networks. Conversely, Eu at the concentrations of 100, 200, and 300 μM/g was not conducive to gelling ability, especially at 300 μM/g, and these concentrations were associated with Eu-induced protein conformational changes. (Eu 0, 0 (0 100 200 30 μMg μM g MP. . (MP) oxidationinduced induced groups Moreover αhelical α helical stress 1 5 networks Conversely Euinduced ( 20 3 (MP 2

Abstract Objective Since coronary artery lesions (CALs) are the most severe complication of Kawasaki disease (KD), clinically speaking, early prediction of CALs is crucial. The authors aimed to investigate the predictive value of C-reactive protein (CRP) in predicting CALs in KD patients. Methods KD patients were divided into the CALs group and the non-CALs group. The clinical and laboratory parameters were collected and compared. Multivariate logistic regression analysis was used to determine the independent risk factors of CALs. The receiver operating characteristic curve was applied to determine the optimal cut-off value. Results 851 KD patients who met the inclusion criteria were studied, including 206 in the CALs group and 645 in the non-CALs group. Children in the CALs group had significantly higher CRP levels than the non-CALs group (p< 0.05). Multivariable logistic regression analysis showed that incomplete KD, male, lower hemoglobin, and higher CRP were independent risk factors for predicting CAL (all p< 0.05). The optimal cut-off value of initial serum CRP for predicting CALs was 105.5 mg/L, with a sensitivity of 47.57% and a specificity of 69.61%. In addition, KD patients with high CRP (≥105.5 mg/L) had a higher occurrence of CALs than those with low CRP (<105.5 mg/L) (33% vs 19%, p< 0.001). Conclusion The incidence of CALs was significantly higher in patients with high CRP. CRP is an independent risk factor for CALs formation and may be useful for predicting CALs in KD patients. (CALs , (KD) speaking crucial Creactive C reactive (CRP nonCALs non compared cutoff cut off 85 studied 20 64 p (p 0.05. 005 0.05 . 0 05 0.05) male hemoglobin all 1055 105 5 105. mgL mg L mg/L 4757 47 57 47.57 6961 69 61 69.61% addition ≥105.5 (≥105. <105.5 (<105. 33% 33 (33 19 19% 0.001. 0001 0.001 001 0.001) (KD 8 2 6 00 0.0 10 475 4 47.5 696 69.61 ≥105. (≥105 <105. (<105 3 (3 1 000 0.00 0. 47. 69.6 ≥105 (≥10 <105 (<10 ( 69. ≥10 (≥1 <10 (<1 ≥1 (≥ <1 (< ≥ <

ABSTRACT To explore the functions of Txnip and its mechanism in adipocyte differentiation, the preadipocytes were isolated from subcutaneous adipose tissue of three-day-old piglets and induced into adipogenic differentiation. The expression of Txnip and ChREBP was silenced, and the Txnip overexpression was achieved in the cells with transfection of the recombinant lentivirus strategies. Txnip silencing promoted the differentiation of porcine preadipocytes and PPARγ expression, and a PPARγ inhibitor reduced this facilitation. Instead, Txnip overexpression exerted a suppressive effect on the cell differentiation and PPARγ expression, and the PPARγ agonist offset this inhibition. High glucose stimulated the preadipocyte differentiation and expressions of ChREBP and Txnip. In contrast, Txnip expression was reduced by ChREBP silencing, suggesting glucose-regulated Txnip expression through the mediation of ChREBP. Moreover, the expressions of ChREBP and Glut4 induced by high glucose and glucose uptake of the cells were reduced by Txnip-overexpression, but increased by Txnip silencing, while these changes of Txnip did not alter their expressions under low glucose. Collectively, Txnip could be an inhibitor of porcine preadipocyte differentiation, which attenuated the adipogenesis through the negative feedback regulation on PPARγ. Txnip impaired the induction of glucose on the preadipocyte differentiation through decreasing Glut4 expression and glucose uptake and subsequent decrease of the expression and transcriptional activity of ChREBP. threedayold three day old silenced strategies facilitation Instead inhibition contrast glucoseregulated regulated Moreover Glut Txnipoverexpression, Txnipoverexpression overexpression, Txnip-overexpression Collectively

Resumo O romance 活着 (huó zhe, Viver), do prestigiado escritor chinês Yu Hua, é considerado um dos romances mais influentes na história da literatura chinesa contemporânea e foi traduzido no Brasil (Yu, 2008) e em Portugal (Yu, 2019). Como o romance é marcado pela abundância de palavras com carga cultural, o presente trabalho tem como objeto a tradução das palavras com carga cultural nas duas referidas versões de tradução do romance à luz da eco-translatologia (proposta pelo teórico chinês Hu Gengshen), com uma análise qualitativa de caso sobre o grau de transformação tridimensional. O artigo fará o levantamento de todas as palavras com carga cultural no romance Viver, selecionará as palavras mais representativas, comparará as traduções destas palavras por dois tradutores e avaliará seus desempenhos em termos do grau de transformação tridimensional para enriquecer os resultados teóricos da eco-translatologia. huó zhe Viver , Viver) Hua Yu, (Yu 2008 2019. 2019 . 2019) ecotranslatologia eco translatologia proposta Gengshen, Gengshen Gengshen) representativas ecotranslatologia. translatologia. 200 201 20 2

Abstract The novel 活着 (huó zhe, To Live) written by the prestigious Chinese writer, Yu Hua, is considered as one of the most influential novels in the history of contemporary Chinese literature and has been translated in Brazil (Yu, 2008) and Portugal (Yu, 2019). As the novel is marked by the abundance of culture-loaded words, the present paper has its research object as the translation of culture-loaded words in the two mentioned translation versions of the novel in the light of eco-translatology (proposed by Chinese theorist Hu Gengshen), with a qualitative case analysis on the degree of three-dimensional transformation. The paper will survey all culture-loaded words in the novel To Live, selecting the most representative words, comparing the translations of these words by the two translators, and evaluating their performances in terms of the degree of three-dimensional transformation to enrich the theoretical results of eco-translatology. huó zhe Live writer Hua Yu, (Yu 2008 2019. 2019 . 2019) cultureloaded culture loaded ecotranslatology eco translatology proposed Gengshen, Gengshen , Gengshen) threedimensional three dimensional translators ecotranslatology. translatology. 200 201 20 2

RESUMO Introdução Os dançarinos devem ter as qualidades de força necessárias para completar as técnicas de movimento de dança, a capacidade de coordenar os movimentos e o corpo, além de conferir total capacidade de execução às qualidades como força muscular, poder explosivo e controle em movimento acelerado. Objetivo Verificar a principal morfologia muscular dos membros inferiores dos bailarinos esportivos. Métodos 24 alunos de graduação foram selecionados de uma escola de esportes de uma universidade, especializados em dança esportiva, divididos em três grupos para experimento de aptidão física. Resultados Diferentes pressões do treinamento responderam com efeitos diferentes sobre a espessura dos principais músculos dos membros inferiores. Em comparação com a espessura do reto femoral no estado de repouso antes da experiência, a espessura muscular imediatamente após o exercício foi significativamente aumentada nos grupos de 250 e 300 (P<0,05). Conclusão O treinamento a um nível de pressão moderado - valor de pressão de 200 mmHg a 250 mmHg - pode alcançar melhores resultados. O protocolo apresentado resultou numa melhora funcional do músculo esquelético. Nível de evidência II; Estudos terapêuticos -investigação dos resultados do tratamento.

ABSTRACT Introduction The dancers must have the necessary strength qualities to complete the dance movement techniques and coordinate the body movements, besides giving full capacity of execution to the qualities such as muscular strength, explosive power, and control in accelerated movement. Objective Verify the main muscular morphology of the lower limbs of sports dancers. Methods 24 undergraduate students were selected from a sports school of a university, specialized in sports dance, and divided into three groups for a physical fitness experiment. Results Different training pressures responded with different effects on the thickness of major lower limb muscles. Compared to the thickness of the rectus femoris in the resting state before the experiment, muscle thickness immediately after exercise was significantly increased in the 250 and 300 groups (P<0.05). Conclusion Training at a moderate pressure level - pressure value of 200 mmHg to 250 mmHg - can achieve better results. The presented protocol resulted in a functional improvement of the skeletal muscle. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMEN Introducción Los bailarines deben tener las cualidades necesarias de fuerza para completar las técnicas de movimiento de la danza, la capacidad de coordinar los movimientos y el cuerpo, además de dar total capacidad de ejecución a las cualidades como fuerza muscular, potencia explosiva y control en el movimiento acelerado. Objetivo Verificar la principal morfología muscular de los miembros inferiores de los bailarines deportivos. Métodos Se seleccionaron 24 estudiantes de grado de una escuela de deportes de una universidad, especializada en danza deportiva, divididos en tres grupos para el experimento de aptitud física. Resultados Las diferentes presiones de entrenamiento respondieron con diferentes efectos sobre el grosor de los principales músculos de las extremidades inferiores. En comparación con el grosor del recto femoral en estado de reposo antes del experimento, el grosor del músculo inmediatamente después del ejercicio aumentó significativamente en los grupos 250 y 300 (P<0,05). Conclusión El entrenamiento a un nivel de presión moderado - valor de presión de 200 mmHg a 250 mmHg - puede lograr mejores resultados. El protocolo presentado dio lugar a una mejora funcional del músculo esquelético. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.