Emerging evidence demonstrates that curcumin has an inhibitory effect on non-small cell lung cancer (NSCLC), and its targets and mechanism of action need further exploration. The goal of this study was to explore the potential targets and mechanism of curcumin against NSCLC by network pharmacology, bioinformatics, and experimental validation, thereby providing more insight into combination treatment with curcumin for NSCLC in preclinical and clinical research. Curcumin targets against NSCLC were predicted based on HIT2.0, STD, CTD, and DisGeNET, and the core targets were analyzed via protein-protein interaction network construction (PPI), Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and molecular docking. The gene expression levels of samples in A549 cells, NCI-H460, and curcumin treated groups were detected by real-time quantitative PCR. A total of 67 common targets between curcumin and NSCLC were collected by screening public databases. GO and KEGG analysis suggested that curcumin treatment of NSCLC mainly involves cancer-related pathways, such as PI3K-AKT signaling pathway, Foxo signaling pathway, microRNAs, MAPK signaling pathway, HIF-1 signaling pathway, etc. The targets with the highest degree were identified through the PPI network, namely CASP3, CTNNB1, JUN, IL6, MAPK3, HIF1A, STAT3, AKT1, TP53, CCND1, VEGFA, and EGFR. The results of the in vitro experiments showed that curcumin treatment of NSCLC down-regulated the gene expressions of CCND1, CASP3, HIF1A, IL-6, MAPK3, STAT3, AKT1, and TP53. Our findings revealed that curcumin functions as a potential therapeutic candidate for NSCLC by suppressing multiple signaling pathways and interacting with multiple gene targets. nonsmall non small NSCLC, , (NSCLC) exploration pharmacology bioinformatics validation research HIT20 HIT HIT2 0 HIT2.0 STD CTD DisGeNET proteinprotein protein PPI, (PPI) GO, (GO) KEGG, (KEGG) docking A54 cells NCIH460, NCIH460 NCIH NCI H460, H460 H NCI-H460 realtime real time PCR 6 databases cancerrelated related PI3KAKT PIKAKT PI3K AKT PI K pathway microRNAs HIF1 HIF 1 HIF- etc CASP3 CASP CTNNB1 CTNNB JUN IL6 IL MAPK3 HIF1A HIFA STAT3 STAT AKT1 TP53 TP CCND1 CCND VEGFA EGFR downregulated down regulated 6, IL-6 (NSCLC HIT2. (PPI (GO (KEGG A5 NCIH46 H46 NCI-H46 KAKT PIK TP5 IL- NCIH4 H4 NCI-H4 NCI-H

Abstract Background and aims The association of blood transfusion with an increase in medium- and short-term mortality in specific populations has been confirmed. However, the correlation between blood transfusion and long-term mortality in the general population remains unclear. This cohort study evaluated the correlation between blood transfusion and overall and cause-specific mortality in the general American adult population. Methods The authors utilized 10 sets of 2-year cycle data (1999-2018) from the National Health and Nutrition Examination Survey on the outcomes of adults who did and did not receive blood transfusions. Propensity score-matching (1:1) was performed based on age, sex, race, education level, marital status, poverty-income ratio, arteriosclerotic cardiovascular disease, cancer, anemia, hypertension, and diabetes status. After controlling for demographic characteristics and clinical risk factors, Cox regression analysis was performed to evaluate the correlation between blood transfusion and all-cause and cause-specific mortality. Results The study included 48,004 adult participants. The risk of all-cause mortality increased by 101 % with blood transfusion, and the risk of cardiovascular mortality increased by 165 %. After propensity score-matching, 6,116 pairs of cases were retained, and the risk of all-cause mortality increased by 84 % with blood transfusion, and the risk of cardiovascular mortality increased by 137 %. The sensitivity analysis results were robust. Conclusions In the general American population, blood transfusion significantly impacts long-term all-cause and cardiovascular mortality and may be an unacknowledged risk factor for death. Thus, the effective management of blood transfusion in the general population may be beneficial. medium shortterm short term confirmed However longterm long unclear causespecific cause 1 2year year 2 19992018 1999 2018 (1999-2018 transfusions scorematching score matching 11 (1:1 age sex race level status povertyincome poverty income ratio disease cancer anemia hypertension factors allcause all 48004 48 004 48,00 participants 16 scorematching, matching, 6116 6 116 6,11 retained 8 13 robust death Thus beneficial 1999201 199 201 (1999-201 (1: 4800 4 00 48,0 611 6,1 199920 19 20 (1999-20 (1 480 0 48, 61 6, 19992 (1999-2 ( (1999- (1999 (199 (19

Silicon catalysts have very low catalytic activity in polyester (PET). However, titanium catalysts have high catalytic activity in polyester. The simultaneous use of titanium and silicon catalysts is effective in reducing the activity of a single titanium catalytic base agent. In addition, the glycol salts of titanium and silicon (Ti-EG and Si-EG) prepared in the present invention for use in the polyester catalytic process can avoid the introduction of other groups of impurities during the polyester catalytic process, which would lead to premature capping of the polyester in the process of polycondensation and chain building and make it difficult to increase the molecular weight, and thus affect the quality of the polyester. It has been verified that the ratio of Ti:Si is 1:1 (mol), and total amount added to the catalyst is 0.15% of the raw material amount, and the polycondensation temperature was 260-280 °C for 60 min. Compared with the single Ti-EG catalyst, the b* value of the synthesized PET was significantly reduced, and the molecular weight and other indexes did not change too much. In addition, at the end of catalysis, the catalyst was uniformly dispersed in the reaction system, which could be used as a matting agent for PET. . (PET) However addition TiEG Ti EG SiEG Si Si-EG TiSi 11 1 1: mol, mol , (mol) 015 0 15 0.15 260280 260 280 260-28 C 6 min b reduced much catalysis system (PET (mol 01 0.1 26028 26 28 260-2 0. 2602 2 260-

Abstract Background and purpose: the Dietary Approaches to Stop Hypertension (DASH) diet has multifunctional health benefits. We evaluated the effects of low-sodium salt applied to Chinese modified DASH diet on arterial stiffness in older patients with hypertension and type 2 diabetes. Methods: sixty-one older adults with hypertension and type 2 diabetes were randomly allocated to low sodium salt group (n = 31) or normal sodium salt group (n = 30). They were given the Chinese modified DASH diet plus low-sodium salt (52 % sodium chloride) or same diet plus regular salt (99 % sodium chloride) for eight weeks, respectively. Brachial and ankle pulse wave conduction velocity, ankle brachial index and atherosclerosis-related indices were measured at baseline and week 8. In addition, 24-hour urine and blood samples were measured at baseline, the 4th week and the end of the intervention. Results: as compared with the baseline, the low sodium salt group significantly decreased in ankle brachial index (-0.09 ± 0.11, p < 0.001) and brachial and ankle pulse wave conduction velocity (-133.07 ± 265.99 cm/s, p = 0.010) at week 8 while the normal sodium salt group only decreased significantly in ankle brachial index (-0.06 ± 0.12, p = 0.010) at week 8. Conclusion: the low-sodium salt applied to Chinese modified DASH diet may improve arterial stiffness in patients with hypertension and type 2 diabetes. Further research with an extended follow-up is needed.

Resumen Antecedentes y propósito: la dieta DASH (del inglés Dietary Approaches to Stop Hypertension) tiene beneficios multifuncionales para la salud. Evaluamos los efectos de una sal baja en sodio aplicada a la versión modificada china de la dieta DASH sobre la rigidez arterial en pacientes mayores con hipertensión y diabetes tipo 2. Métodos: sesenta y un adultos mayores con hipertensión arterial y diabetes tipo 2 fueron asignados al azar al grupo de sal baja en sodio (n = 31) o al grupo de sal con contenido normal de sodio (n = 30). Se les administró la versión china modificada de la dieta DASH más sal baja en sodio (52 % de cloruro de sodio) o la misma dieta más sal con la cantidad normal de sodio (99 % cloruro de sodio) durante ocho semanas, respectivamente. Se midieron la velocidad de onda de pulso brazo-tobillo, el índice brazo-tobillo y los índices relacionados con la aterosclerosis al inicio del estudio y a la semana 8. Se recogieron muestras de orina y sangre de 24 horas al inicio, a la cuarta semana y al final de la intervención. Resultados: en comparación con el estado inicial, el grupo de sal baja en sodio disminuyó significativamente el índice brazo-tobillo (-0,09 ± 0,11, p < 0,001) y la velocidad de onda de pulso brazo-tobillo (-133,07 ± 265,99 cm/s, p = 0,010) en la semana 8, mientras que el grupo de sal con contenido normal de sodio solo disminuyó significativamente en el índice brazo-tobillo (-0,06 ± 0,12, p = 0,010) en la semana 8. Conclusión: la sal baja en sodio aplicada a la versión china modificada de la dieta DASH puede mejorar la rigidez arterial en pacientes con hipertensión y diabetes tipo 2. Se necesitan más investigaciones con un seguimiento prolongado.

Abstract Aim: to investigate the effects of low sodium formula salt combined with the Chinese Modified Dietary Approaches to Stop Hypertension (DASH) diet on cerebrovascular function in patients with hypertension and type 2 diabetes. Methods: an eight-week single-arm trial was conducted in 66 patients with hypertension and type 2 diabetes to investigate effects of low sodium formula salt (potassium chloride 56 %, sodium chloride 23 %, 5 g/day) combined with Chinese Modified DASH diet on cerebrovascular function (measured by transcranial Doppler sonography), indicators of chronic diseases (blood pressure, blood glucose and blood lipids) and urinary excretion. The above indicators were performed before and after intervention. Results: fifty-nine subjects completed the study. Peak systolic velocity, mean flow velocity, end-diastolic velocity, pulsatility index and resistance index of internal cerebral artery and vertebral artery decreased significantly (p < 0.05); pulsatility index and resistance index of anterior cerebral artery and middle cerebral artery decreased significantly (p < 0.05); and end-diastolic velocity and pulsatility index of basilar artery decreased significantly (p < 0.05). Systolic blood pressure, diastolic blood pressure, fasting blood glucose and postprandial blood glucose decreased significantly (p < 0.001; p < 0.001; p < 0.001; p < 0.001). Blood pressure and blood glucose control rates increased significantly (p < 0.001). Conclusions: based on the study, 23 % low-sodium formula combined with CM-DASH diet pattern can improve cerebrovascular function in community patients with hypertension complicated with diabetes and has a good short-term benefit of blood pressure and glucose control.

Resumen Objetivo: investigar los efectos de una sal baja en sodio combinada con la versión china de la dieta DASH (del inglés Dietary Approaches to Stop Hypertension) modificada en la función cerebrovascular en pacientes con hipertensión y diabetes tipo 2. Métodos: en 66 pacientes con hipertensión y diabetes tipo 2 se llevó a cabo un ensayo de ocho semanas para investigar los efectos de la sal baja en sodio (cloruro de potasio 56 %, cloruro de sodio 23 %, 5 g/día) combinada con la dieta DASH en su versión china modificada en la función cerebrovascular (medido por sonografía Doppler transcraneal), los indicadores de enfermedades crónicas (presión arterial, glucosa sanguínea y lípidos sanguíneos) y la excreción urinaria. Los indicadores anteriores se midieron antes y después de la intervención. Resultados: cincuenta y nueve sujetos completaron el estudio. La velocidad sistólica máxima, la velocidad media del flujo, la velocidad diastólica final, el índice de pulsatilidad y el índice de resistencia de la arteria cerebral anterior y la arteria vertebral disminuyeron significativamente (p < 0,05); el índice de pulsatilidad y el índice de resistencia de la arteria cerebral anterior y la arteria media disminuyeron significativamente (p < 0,05); y la velocidad diastólica final y el índice de pulsatilidad de la arteria basilar disminuyeron significativamente (p < 0,05). La presión arterial sistémica, la presión arterial diastólica, la glucosa arterial en ayuno y la glucemia posprandial disminuyeron significativamente (p < 0,001, p < 0,001, p < 0,001, p < 0,001). La presión arterial y las tasas de control de glucosa en sangre aumentaron significativamente (p < 0,001). Conclusiones: la fórmula de sal con un 23 % de sodio combinada con la dieta DASH en su versión china modificada puede mejorar la función cerebrovascular en pacientes comunitarios con hipertensión complicada por la diabetes y es beneficiosa a corto plazo para la presión arterial y el control de la glucosa.

RESUMO Introdução Os jogos de futebol são de longa duração e de maior confrontação; na segunda metade do jogo, muitos jogadores têm um declínio em seu nível físico, levando à perda das partidas. Objetivo Explorar o efeito do treinamento com peso na condição física nos membros inferiores dos jogadores de futebol. Métodos 60 atletas foram incluídos como sujeitos e divididos aleatoriamente em grupo de controle, grupo de musculação e grupo de musculação física tradicional. Todos os atletas treinaram por 45 minutos 3 vezes por semana durante 6 semanas. Antes e depois do treinamento, a força dos membros inferiores e a propriocepção foram avaliadas, e a força do grupo flexor e extensor do joelho foi avaliada pelo testador muscular isocinético. Resultados Tanto o treinamento físico com peso quanto o treinamento físico tradicional conseguiram melhorar o desempenho do salto vertical dos jovens jogadores de futebol, os efeitos do treinamento dos dois grupos foram equivalentes. Conclusão O treinamento com peso tem o mesmo efeito de aprimoramento que o treinamento físico tradicional em termos de força e poder explosivo, promovendo o desempenho atlético em jogadores de futebol juvenil. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

ABSTRACT Introduction Soccer games are of long duration and more confrontational; in the second half of the game, many players have a decline in their physical level, leading to loss of matches. Objective To explore the effect of weight training on lower limb fitness in soccer players. Methods 60 athletes were included as subjects and randomly divided into control group, weight training group, and traditional physical fitness training group. All athletes trained for 45 minutes 3 times a week for 6 weeks. Before and after training, lower limb strength and proprioception were evaluated, and the strength of the knee flexor and extensor group was assessed by isokinetic muscle tester. Results Both weight training and traditional physical training were able to improve the vertical jump performance of young soccer players, the training effects of both groups were equivalent. Conclusion Weight training has the same enhancing effect as traditional physical training in terms of strength and explosive power, promoting athletic performance in youth soccer players. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMEN Introducción Los partidos de fútbol son de larga duración y de mayor confrontación; en la segunda mitad del partido, muchos jugadores tienen un descenso en su nivel físico, lo que lleva a la pérdida de partidos. Objetivo Explorar el efecto del entrenamiento con pesas sobre la aptitud de las extremidades inferiores en jugadores de fútbol. Métodos Se incluyeron 60 atletas como sujetos y se dividieron aleatoriamente en el grupo de control, el grupo de entrenamiento con pesas y el grupo de acondicionamiento físico tradicional. Todos los atletas entrenaron 45 minutos 3 veces por semana durante 6 semanas. Antes y después del entrenamiento, se evaluó la fuerza de las extremidades inferiores y la propiocepción, y la fuerza del grupo de flexores y extensores de la rodilla se evaluó mediante un probador muscular isocinético. Resultados Tanto el entrenamiento con pesas como el entrenamiento físico tradicional fueron capaces de mejorar el rendimiento del salto vertical de los jóvenes futbolistas, los efectos del entrenamiento de ambos grupos fueron equivalentes. Conclusión El entrenamiento con pesas tiene el mismo efecto potenciador que el entrenamiento físico tradicional en términos de fuerza y potencia explosiva, promoviendo el rendimiento atlético en los jugadores de fútbol juvenil. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

RESUMO Introdução A potência explosiva dos membros inferiores é um índice indispensável no futebol. Ter um bom nível de potência explosiva estabelece uma base sólida para o desempenho e o nível competitivo dos futebolistas. Objetivo Promover as condições para melhorar o nível explosivo dos jogadores de futebol e aperfeiçoar seu desempenho e nível competitivo. Métodos Este documento apresenta a influência do treinamento de força composta no poder explosivo dos membros inferiores dos atletas de futebol. Com base em 27 jovens jogadores de futebol com 9 anos de idade do Zai Ming Football Club de uma faculdade esportiva como material experimental, foi realizado o treinamento composto. Resultados As taxas de crescimento destes índices no grupo experimental foram de 3,3%, 2,3%, 5,0%, 3,6%, 9,2%, 12,1%, 20,5%, 5,7%, 11,9%, 16,9% e 19,5% respectivamente, enquanto os do grupo de controle foram de 1,2%, 0,7%, 4,2%, 3,1%, 6,8%, 7,8%, 5,1%, 4,2%, 4,8%, 12,5% e 19,2% respectivamente. A taxa de crescimento do grupo experimental foi maior do que a do grupo de controle e do grupo de controle em branco. Conclusão Em comparação com o grupo de controle e o grupo de controle neutro, o grupo experimental com treinamento composto tem um melhor efeito de treinamento para melhorar a explosividade dos membros inferiores dos jogadores de futebol juvenil. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

ABSTRACT Introduction The explosive power of the lower limbs is an indispensable index in soccer. Having a good level of explosive power establishes a solid foundation for the performance and the competitive level of soccer players. Objective Promote the conditions to improve the explosive level of soccer players and improve their performance and competitive level. Methods This paper presents the influence of compound strength training on the explosive power of the lower limbs of soccer athletes. Based on 27 young 9-year-old soccer players from Zai Ming Football Club of a sports college as experimental material, the composite training was carried out. Results The growth rates of these rates in the experimental group were 3.3%, 2.3%, 5.0%, 3.6%, 9.2%, 12.1%, 20.5%, 5.7%, 11.9%, 16.9% and 19.5% respectively, while those in the control group were 1.2%, 0.7%, 4.2%, 3.1%, 6.8%, 7.8%, 5.1%, 4.2%, 4.8%, 12.5% and 19.2% respectively. The growth rate of the experimental group was higher than that of the control group and the blank control group. Conclusion Compared with the control group and the neutral control group, the experimental group with compound training has a better training effect on improving the lower limb explosiveness of youth soccer players. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMEN Introducción La potencia explosiva de los miembros inferiores es un índice indispensable en el fútbol. Tener un buen nivel de potencia explosiva establece una base sólida para el rendimiento y el nivel competitivo de los futbolistas. Objetivo Promover las condiciones para mejorar el nivel explosivo de los futbolistas y mejorar su rendimiento y nivel competitivo. Métodos Este trabajo presenta la influencia del entrenamiento de fuerza compuesta en la potencia explosiva de los miembros inferiores de los atletas de fútbol. Se llevó a cabo el entrenamiento compuesto con 27 jóvenes jugadores de fútbol de 9 años del Club de Fútbol Zai Ming de una escuela deportiva como material experimental. Resultados Las tasas de crecimiento de estos índices en el grupo experimental fueron del 3,3%, 2,3%, 5,0%, 3,6%, 9,2%, 12,1%, 20,5%, 5,7%, 11,9%, 16,9% y 19,5% respectivamente, mientras que las del grupo de control fueron del 1,2%, 0,7%, 4,2%, 3,1%, 6,8%, 7,8%, 5,1%, 4,2%, 4,8%, 12,5% y 19,2% respectivamente. La tasa de crecimiento del grupo experimental fue mayor que la del grupo de control y del grupo de control en blanco. Conclusión En comparación con el grupo de control y el grupo de control neutro, el grupo experimental con entrenamiento compuesto tiene un mejor efecto de entrenamiento para mejorar la explosividad de las extremidades inferiores de los futbolistas juveniles. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

RESUMEN Introducción: Aunque el desarrollo de los ejercicios ha presentado un gran progreso teórico, todavía existen muchos problemas en relación con el proceso actual de educación deportiva en el entrenamiento de la condición física dedicado al baloncesto. Una de las necesidades actuales es la evaluación de los métodos actuales de entrenamiento de sus jugadores y el método de introducción funcional en este escenario. Objetivo: Explorar las características físicas y los métodos de entrenamiento funcional en diferentes posiciones de los jugadores de baloncesto. Métodos: Se realizó una búsqueda bibliográfica para sondear las prácticas científicas actuales y se tomaron como objeto de estudio los deportistas de la segunda selección nacional de baloncesto masculina y femenina que participaron en un entrenamiento de invierno del 10 de enero al 10 de marzo de 2019, considerando también las diferentes posiciones de los deportistas en activo de la CBA, WCBA, NBA y WNBA. Resultados: Los resultados mostraron que el nivel medio de ácido láctico en sangre de las atletas del segundo equipo nacional de baloncesto femenino era de 11,19mmol/L, ligeramente inferior al de las atletas del equipo nacional femenino (11,8±1,2mmol/L), lo que indica que la capacidad anaeróbica de las atletas alcanzó un nivel elevado. Conclusión: Los jugadores de baloncesto en diferentes posiciones tienen diferentes exigencias en cuanto a características físicas y métodos de entrenamiento. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento. Introducción teórico escenario Objetivo Métodos 1 2019 CBA WCBA WNBA Resultados 1119mmolL mmolL 11 19mmol L mmol 11,19mmol/L 11,8±1,2mmol/L, 11812mmolL 11,8±1,2mmol/L , 8 2mmol (11,8±1,2mmol/L) elevado Conclusión II tratamiento 201 (11,8±1,2mmol/L 20 2

RESUMO Introdução: Embora o desenvolvimento de exercícios tenha apresentado grandes progressos teóricos, ainda há muitos problemas quanto ao atual processo de ensino esportivo no treinamento de aptidão física dedicado ao basquetebol. Uma das necessidades atuais é a avaliação dos métodos de treinamento atual de seus jogadores e o método de introdução funcional neste cenário. Objetivo: Explorar as características físicas e os métodos de treinamento funcional em diferentes posições dos jogadores de basquetebol. Métodos: Efetuou-se uma pesquisa bibliográfica para levantamento das práticas científicas atuais e tomou-se como objetos de estudo os atletas da segunda equipe nacional masculina e feminina de basquetebol que participaram de um treinamento de inverno de 10 de janeiro a 10 de março de 2019, considerando também as diferentes posições dos atletas ativos da CBA, WCBA, NBA e WNBA. Resultados: Os resultados mostraram que o nível médio de ácido láctico no sangue das atletas da segunda equipe nacional feminina de basquetebol foi de 11,19mmol/L, o que foi ligeiramente inferior ao das atletas da seleção nacional feminina (11,8±1,2mmol/L), indicando que a capacidade anaeróbica das atletas atingiu um nível elevado. Conclusão: Jogadores de basquetebol em diferentes posições têm diferentes exigências quanto às características físicas e métodos de treinamento. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento. Introdução teóricos cenário Objetivo Métodos Efetuouse Efetuou se tomouse tomou 1 2019 CBA WCBA WNBA Resultados 1119mmolL mmolL 11 19mmol L mmol 11,19mmol/L 11,8±1,2mmol/L, 11812mmolL 11,8±1,2mmol/L , 8 2mmol (11,8±1,2mmol/L) elevado Conclusão II tratamento 201 (11,8±1,2mmol/L 20 2

ABSTRACT Introduction: Although exercise development has shown great theoretical progress, there are still many problems regarding the current sports teaching process in physical fitness training dedicated to basketball. One of the current needs is the evaluation of the current training methods of its players and the functional introduction method in this scenario. Objective: Explore the physical characteristics and functional training methods in different positions of basketball players. Methods: A literature search was conducted to survey the current scientific practices and the athletes of the second national men's and women's basketball team who participated in a winter training from January 10 to March 10, 2019 were taken as the objects of study, also considering the different positions of the active athletes of the CBA, WCBA, NBA and WNBA. Results: The results showed that the average blood lactate level of the second national women's basketball team was 11.19mmol/L, slightly lower than the national women's team (11.8±1.2mmol/L), indicating that the athletes’ anaerobic capacity reached a high level. Conclusion: Basketball players in different positions have different demands regarding physical characteristics and training methods. Level of evidence II; Therapeutic studies - investigation of treatment outcomes. Introduction progress scenario Objective Methods mens men s womens women 1 201 study CBA WCBA WNBA Results 1119mmolL mmolL 11 19mmol L mmol 11.19mmol/L 11.8±1.2mmol/L, 11812mmolL 11.8±1.2mmol/L , 8 2mmol (11.8±1.2mmol/L) Conclusion II outcomes 20 (11.8±1.2mmol/L 2

Abstract Purposes: Braided and laser-cut stents both are efficacious and safe for coiling intracranial aneurysms. The study aimed to compare outcomes following braided stent-assisted coil embolization versus laser engraved stent-assisted coil embolization in 266 patients who were diagnosed with unruptured intracranial aneurysms of different types and locations. Methods: Patients with unruptured complex intracranial aneurysms underwent braided (BSE cohort, n = 125) or laser engraved (LSE cohort, n = 141) stent-assisted embolization. Results: The deployment success rate was higher for patients of the LSE cohort than those of the BSE cohort (140 [99%] vs. 117 [94%], p = 0.0142). Seventy-one (fifty-seven percentages) and 73 (52%) were coil embolization procedure success rates of the BSE and the LSE cohorts. Periprocedural intracranial hemorrhage was higher in patients of the BSE cohort than those of the LSE cohort (8 [6%] vs. 1 [1%], p = 0.0142). Four (three percentages) patients from the LSE cohort and 3 (2%) patients from the BSE cohort had in-stent thrombosis during embolization. Permanent morbidities were higher in patients of the LSE cohort than those of the BSE cohort (8 [6%] vs. 1 [1%], p = 0.0389). Higher successful procedures (76% vs. 68%) and fewer postprocedural intracranial hemorrhage (0% vs. 5%) and mortality (0% vs. 5%) were reported for patients of the BSE cohort in posterior circulation aneurysmal location than those of the LSE cohort. Laser engraved stent has fewer problems with deployment and may have better periprocedural and follow-up outcomes after embolization. Conclusions: Braided stent-assisted embolization should be preferred when the aneurysm is present in the posterior circulation. Purposes lasercut cut stentassisted assisted 26 locations Methods 125 141 Results 140 (14 99% 99 [99% vs 11 94%, 94 94% , [94%] 0.0142. 00142 0.0142 . 0 0142 0.0142) Seventyone Seventy one fiftyseven fifty seven percentages 7 52% 52 (52% cohorts 8 ( 6% 6 [6% 1%, 1% [1%] three 2% 2 (2% instent 0.0389. 00389 0.0389 0389 0.0389) 76% 76 (76 68% 68 0% (0 5% 5 followup follow up Conclusions 12 14 (1 9 [99 [94% 0014 0.014 014 (52 [6 [1% (2 0038 0.038 038 (7 [9 [94 001 0.01 01 (5 [ [1 003 0.03 03 00 0.0 0.

Abstract Introduction Prior studies have found inconsistent results regarding the relationship between vitamin D status and Idiopathic Central Precocious Puberty (ICPP). Objective To assess the role of serum 25-hydroxyvitamin D (25 [OH]D) levels in ICPP development. Method The authors retrospectively collected data from 221 girls with ICPP and 144 healthy girls between January 2017 and December 2019. The participants’ serum 25(OH)D levels were measured using an automatic chemiluminescence method, and the association between serum 25(OH)D levels and the risk of ICPP was assessed using multivariate logistic regression analysis. Odds Ratios (OR) with 95% Confidence Intervals (95% CI) were calculated as effect estimates. Results Serum 25(OH)D levels in the ICPP group were significantly lower than those in healthy controls (p < 0.001). Multivariate analysis indicated that girls with insufficient vitamin D levels (OR = 0.201; 95% CI 0.094-0.428; p < 0.001) and sufficient vitamin D levels (OR = 0.141; 95% CI 0.053-0.375; p < 0.001) both had a lower risk of ICPP than girls with vitamin D deficiency. Moreover, the authors found that the height (p = 0.014), weight (p = 0.014), breast stage (p = 0.010), mother's height (p < 0.001), and luteinizing hormone/follicle-stimulating hormone ratio (p = 0.010) in girls with ICPP could be associated with levels of vitamin D. Conclusion This study found that a low serum 25(OH)D level is an independent risk factor for ICPP, and several characteristics of girls with ICPP could be affected by their vitamin D status. ICPP. . (ICPP) 25hydroxyvitamin hydroxyvitamin 25 (2 OHD OH [OH]D development 22 14 201 2019 participants 25OHD method OR 95 (95 estimates 0.001. 0001 0.001 0 001 0.201 0201 0.0940.428 00940428 0.094 0.428 094 428 0.094-0.428 0.141 0141 141 0.0530.375 00530375 0.053 0.375 053 375 0.053-0.375 deficiency Moreover 0.014, 0014 0.014 , 014 0.014) 0.010, 0010 0.010 010 mothers mother s 0.001, hormone/folliclestimulating hormonefolliclestimulating hormone/follicle stimulating follicle (ICPP 2 ( 1 20 9 (9 000 0.00 00 0.20 020 0940 0.0940.42 0094042 0094 0.09 0428 0.42 09 42 0.094-0.42 0.14 0530 0.0530.37 0053037 0053 0.05 0375 0.37 05 37 0.053-0.37 0.01 01 folliclestimulating hormonefollicle 0.0 0.2 02 0.0940.4 009404 009 042 0.4 4 0.094-0.4 0.1 0.0530.3 005303 005 037 0.3 3 0.053-0.3 0. 0.0940. 00940 04 0.094-0. 0.0530. 00530 03 0.053-0. 0.0940 0.094-0 0.0530 0.053-0 0.094- 0.053-

Gastric cancer (GC) is a serious threat to human health and an important cause of cancer-related death. Herein, we evaluated the influence of transmembrane protein 158 (TMEM158) on GC cell growth. According to Genomic Spatial Event (GSE) and The Cancer Genome Atlas (TCGA) databases, TMEM158 content is amplified in GC tissues. The diagnostic value of TMEM158 expression in GC is huge. GC sufferers with high expression of TMEM158 were associated with poor overall survival. In addition, TMEM158 content was increased in GC cells. TMEM158 promoted GC cell proliferation by modulating the PI3K/Akt signaling pathway. Lack of TMEM158 reduced GC tumor growth. Collectively, TMEM158 accelerated GC cell proliferation by modulating the PI3K/Akt signaling pathway, making it a prospective biomarker for survival in GC patients. (GC cancerrelated related death Herein 15 TMEM (TMEM158 growth GSE (GSE TCGA (TCGA databases TMEM15 tissues huge addition cells PI3KAkt PIKAkt PI3K Akt PI K pathway Collectively patients 1 (TMEM15 TMEM1 KAkt PIK (TMEM1 (TMEM

Abstract Background: studies have shown that dietary factors are linked to female infertility, but the relation between dietary fiber consumption and infertility has not been proven. The purpose of this research was to investigate whether there is an independent association between dietary fiber intake and infertility in American women. Material and methods: a secondary analysis of the National Health and NUTRITION Examination Survey (NHANES) dataset has been conducted, covering three cycles from 2013 to 2018. A total of 3,497 participants were included in the data analysis. The independent and dependent variables of interest were dietary fiber intake and infertility. Covariates included sociodemographic, questionnaire, diet, and physical examination data. Multiple logistic regression and sensitivity analyses were performed to investigate the relationship of dietary fiber intake with infertility. Results: each additional increase in log10 dietary fiber consumption was associated with a 32 % lower risk of infertility (OR, 0.68; 95 % CI, 0.48-0.96). The outcome is still robust in the minimally as well as the fully adjusted model. The possibility of a nonlinear association between dietary fiber intake and infertility was ruled out by the GAM model and smooth curve fitting. The RESULTS showed that there is an inverse linear correlation between dietary fiber intake and infertility. Conclusions: the association between intake of dietary fiber and infertility is linear, and increasing dietary fiber intake may be beneficial for lower infertility.

Resumen Antecedentes: el consumo de fibra dietética es un factor importante en la infertilidad femenina. El objetivo del estudio fue investigar si existe una relación independiente entre el consumo de fibra dietética y la infertilidad en las mujeres estadounidenses. Material y métodos: se realizó un análisis secundario del conjunto de datos de la encuesta nacional de salud y nutrición (NHANES), que abarcó tres ciclos entre 2013 y 2018. Se incluyeron 3497 participantes para el análisis de datos. Las variables independientes y dependientes asociadas fueron la ingesta de fibra dietética y la infertilidad. Las covariables incluyeron datos sociodemográficos, de los cuestionarios, dietéticos y médicos. Se realizó un análisis de regresión logística multivariada y un análisis de sensibilidad para determinar la relación entre el consumo de fibra dietética y la infertilidad. Resultados: cada aumento log10 en el consumo de fibra dietética se asoció con una reducción del 32 % en el riesgo de infertilidad (OR: 0,68; intervalo de confianza del 95 %: 0,48-0,96). En el modelo mínimo y totalmente ajustado, los resultados siguen siendo robustos. El modelo GAM y el ajuste de curvas suavizadas descartaron la posibilidad de una relación no lineal entre la ingesta de fibra dietética y la infertilidad. Los resultados muestran una correlación lineal negativa entre la ingesta de fibra dietética y la infertilidad. Conclusiones: se observó una relación lineal entre la ingesta de fibra dietética y la infertilidad. El aumento de la ingesta de fibra dietética redujo la incidencia de la infertilidad.

Abstract Introduction: hypertension and diabetes are chronic disorders associated with an increased risk of cardiovascular disease. Objectives: to evaluate the effect of 52 % low-sodium salt applied to the Chinese-modified DASH (CM-DASH) diet on risk of atherosclerotic cardiovascular disease (ASCVD) in patients with hypertension and type-2 diabetes. Methods: the low-sodium salt group (LSSG) took 5 g/day of 52 % low-sodium salt plus CM-DASH diet for 8 weeks, while the normal-sodium salt group (NSSG) took the same dose of normal-sodium salt plus CM-DASH diet for 8 weeks. Blood tests, 24-hour urine tests, anthropometric measurements, and 10-year risk of ASCVD prediction were assessed. Results: compared with baseline, both LSSG and NSSG showed a significant reduction in 10-year risk of ASCVD, but we did not find any statistically significant differences in 10-year risk of ASCVD between LSSG and NSSG. Conclusions: our study shows that salt limits and DASH diets reduce the risk of cardiovascular disease whereas low-sodium salt containing 52 % sodium chloride did not significantly lower the risk of cardiovascular disease when compared to regular salt. Due to the limitations of the research, additional studies will be necessary to confirm our findings.

Resumen Introducción: la hipertensión y la diabetes son trastornos crónicos asociados a un mayor riesgo de enfermedad cardiovascular. Objetivos: evaluar el efecto de la sal baja en sodio (52 %) aplicada a la dieta DASH modificada en China (CM-DASH) sobre los riesgos de enfermedad cardiovascular aterosclerótica (ECA) en pacientes con hipertensión arterial y diabetes de tipo 2. Métodos: el grupo de sal baja en sodio (LSSG) tomó 5 g/día de sal baja en sodio al 52 % más dieta CM-DASH durante 8 semanas, mientras que el grupo de sal normal en sodio (NSSG) tomó la misma dosis de sal normal en sodio más dieta CM-DASH durante 8 semanas. Se evaluaron los análisis de sangre, los análisis de orina de 24 horas, las mediciones antropométricas y los riesgos de predicción de ECVA a 10 años. Resultados: en comparación con el valor basal, tanto el LSSG como el NSSG mostraron una reducción significativa de los riesgos a 10 años de ECVA, mientras que no se encontraron diferencias estadísticamente significativas en los riesgos a 10 años de ECVA entre el LSSG y el NSSG. Conclusiones: nuestro estudio muestra que los límites de sal y las dietas DASH reducen el riesgo de enfermedad cardiovascular mientras que la sal baja en sodio con un 52 % de cloruro sódico no redujo significativamente el riesgo de enfermedad cardiovascular en comparación con la sal normal. Debido a las limitaciones de la investigación, serán necesarios estudios adicionales para confirmar nuestros hallazgos

Resumen Objetivos: evaluar el efecto de la reducción de sodio basada en una dieta DASH modificada sobre la presión arterial en pacientes hipertensos con diabetes de tipo 2. Material y métodos: sesenta y un pacientes hipertensos con diabetes de tipo 2 fueron seleccionados de la comunidad y asignados aleatoriamente a un grupo de sal común y un grupo de sal baja en sodio, que recibieron una intervención dietética de 8 semanas en la que las semanas 1-2 fueron la fase de orientación dietética, las semanas 3-4 fueron la fase de alimentación centralizada, y las semanas 5-8 fueron la fase de atención médica domiciliaria. Los participantes fueron seguidos en el hospital una vez por semana para recopilar información sobre la presión arterial, la sal y el uso de drogas en pacientes ambulatorios. Los exámenes físicos se realizaron a las 4 semanas y al final de la intervención, así como al inicio del estudio. Resultados: después de la intervención, la presión arterial tanto del grupo bajo en sodio (PAS: -14,32 mmHg, p < 0,001; PAD: -6,32 mmHg, p < 0,001) como del grupo de sal común (PAS: -10,98 mmHg, p < 0,001; PAD: -5,24 mmHg, p = 0,001) disminuyó significativamente con una disminución más pronunciada en el grupo bajo en sodio pero sin diferencias estadísticamente significativas entre los dos grupos (PAS: -0,28 mmHg, p = 0,929; PAD: -3,32 mmHg, p = 0,093). Al final de la intervención, la ingesta de sodio disminuyó significativamente, pero la ingesta de potasio aumentó en el grupo bajo en sodio (p < 0,05); sin embargo, el grupo de la sal común no tuvo cambios significativos. Conclusión: la reducción de la ingesta de sodio basada en la dieta DASH modificada tuvo un buen efecto sobre la presión arterial sistólica y diastólica en pacientes hipertensos con diabetes de tipo 2. La reducción de sodio basada en la dieta DASH modificada es segura y eficaz, por lo que puede utilizarse como guía para una vida saludable en pacientes hipertensos.

Abstract Objectives: to evaluate the effect of sodium reduction based on a modified DASH diet on blood pressure in hypertensive patients with type 2 diabetes. Material and methods: sixty-one hypertensive patients with type 2 diabetes were selected from the community and randomly allocated to a common salt group and low sodium salt group receiving the 8-week dietary intervention, in which weeks 1-2 was the dietary guidance phase, weeks 3-4 was the centralized feeding phase, and weeks 5-8 was the home medical care phase. Participants were followed up in the hospital once a week to collect information on outpatient blood pressure, salt, and drug use. Physical examinations were conducted at 4 weeks and the end of the intervention, as well as at baseline. Results: after the intervention, the blood pressure of both the low sodium group (SBP: -14.32 mmHg, p < 0.001; DBP: -6.32mmHg, p < 0.001) and the common salt group (SBP: -10.98 mmHg, p < 0.001; DBP: -5.24 mmHg, p = 0.001) decreased significantly with a more pronounced decrease in the low sodium group but no statistically significant differences between the two groups (SBP: -0.28 mmHg, p = 0.929; DBP: -3.32 mmHg, p = 0.093). At the end of the intervention, sodium intake was significantly decreased, but potassium intake was increased in the low sodium group (p < 0.05); however, the common salt group had no significant change. Conclusion: reducing sodium intake based on the modified DASH diet had a good effect on systolic and diastolic blood pressure in hypertensive patients with type 2 diabetes. Sodium reduction based on the modified DASH diet is safe and effective, and can be used as a guide for healthy living in hypertensive patients.

A series of novel betulin-28-hydrazone derivatives (7a-7o) were synthesized. All compounds were evaluated for their in vitro cytotoxicities in four human carcinoma cells (HepG2, MCF-7, HCT-116 and A549). Among them, compound 7l displayed the most potent cytotoxicity with an IC50 (concentration of the tested compound that inhibits 50% of cell growth) value of 7.37 ± 0.38 μM against MCF-7 cells. The preliminary cellular mechanism studies indicated that compound 7l could induce MCF-7 cells apoptosis. The above findings indicated that compound 7l may be used as a lead compound for antitumor agents with improved efficacy.