ABSTRACT Lathyrus is an economically important genus, with different parts of some species used as foodstuff or animal feed. In this study, phytochemical compositions and bioactivities of Lathyrus brachypterus var. brachypterus, L. brachypterus var. haussknechtii, L. nivalis subsp. sahinii and L. tefennicus taxa which are endemic to Türkiye were investigated. Total phenolic and flavonoid contents (TPC, TFC) of methanolic extracts were detected. Then, phytochemical compositions, antioxidant features (radical scavenging (DPPH: 1,1-diphenyl-2-picrylhydrazyl, ABTS: 2,2′-azino-bis(3 ethylbenzothiazoline) 6 sulfonic acid), reducing power (FRAP:Ferric ion reducing antioxidant power, CUPRAC:Cupric ion reducing antioxidant capacity), metal chelating activity (MCA), and the phosphomolybdenum assays (PDA)) and enzyme inhibitory properties of the extracts were also determined. The highest values were found at L. brachypterus var. brachypterus for TPC, L. brachypterus var. haussknechtii for TFC. The highest antioxidant properties were seen in extracts of L. brachypterus var. brachypterus in DPPH, ABTS, FRAP, CUPRAC and PDA assays, while in extract of L. nivalis subsp. sahinii in MCA. The highest enzyme inhibitory activity was found in extract of L. brachypterus var. brachypterus in tyrosinase and glucosidase assays, while in extracts of L. nivalis subsp. sahinii in AChE (acetylcholinesterase), BChE (butyrylcholinesterase) and amylase. Finally, a taxonomic evaluation was made by considering the phytochemicals.

ABSTRACT Background: Inflammation plays a critical role in cardiac remodeling after myocardial infarction (MI). Monocyte to high-density lipoprotein-cholesterol (HDL-C) ratio (MHR) has emerged as a potential indicator of inflammation. Objectives: The study aimed to investigate the prognostic role of MHR at the time of hospital admission in late cardiac remodeling and subsequent 1-year mortality in an academic training and research hospital. Methods: This prospective multicenter study included 231 patients with acute ST-elevation MI. Left ventricular (LV) functions and volumes were assessed by cardiac magnetic resonance (CMR) imaging at 2 weeks and 6 months post-MI. The definition of adverse cardiac remodeling (AR) was based on the increase of LV end-diastolic volume by ≥ 12% at 6 months post-MI. All patients were followed for survival for 1 year after the second CMR imaging measurements. Results: At 6 months post-MI, 20 patients (23.8%) exhibited AR. The median MHR was higher in the AR group compared to the group without AR (2.2 vs. 1.5, p < 0.001). A positive correlation was found between MHR and infarct size in the groups with and without AR. High MHR was an independent predictor of AR (OR: 3.21, p = 0.002). The cut-off value of MHR in predicting AR was found to be >1.6 with 92.7% sensitivity and 70.1% specificity (AUC ± SE: 0.839 ± 0.03, p < 0.001). Mortality risk was 5.62-fold higher in the group with MHR of >1.6 (HR: 5.62, p < 0.001). Conclusions: These results indicate that admission MHR is a useful tool to predict patients with AR who are at risk of progression to heart failure and mortality after MI.

Abstract The present study was conducted to assess the phenolic content, and antibacterial and antioxidant activities of Lathyrus L. species. The extraction of phenolic compounds from whole seeds, seed coat and cotyledon of Lathyrus hierosolymitanus Boiss. and Lathyrus annuus L. seeds was performed employing different solvents. Total phenolic content (TPC) was measured by Folin- Ciocalteau assay, while the antioxidant activity was determined by DPPH radical scavenging activity, and reducing power assay. It was found that TPC of extracts ranged from 0.12 mg to 6.53 mg GAE/gdw. For each solvent, seed coat extracts were generally observed to render higher TPC and antioxidant activities. There was a correlation between TPC and antioxidant activity. In addition, all extracts were also examined for their antimicrobial activity against Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. Methanol extracts showed the highest antibacterial activity which is consistent with TPC, but there was no correlation between TPC and antibacterial activity. Solvents were observed to have effects on gallic acid, caffeic acid, and epicatechin extractions. HPLC analysis results of extracts confirmed methanol and ethanol as preferred solvents for phenolic extraction from Lathyrus sp. Phenolic content in the extracts could be suggested to contribute to their antioxidant and antibacterial activity.

INTRODUÇÃO: O basquete em cadeira de rodas é um esporte paralímpico caracterizado por atividades intermitentes de alta intensidade que exigem força explosiva e velocidade.OBJETIVO: Investigar o efeito do treinamento de força explosiva sobre a velocidade e o desempenho da agilidade em jogadores de basquete em cadeira de rodas.MÉTODOS: Dez jogadores de basquete do sexo masculino em cadeira de rodas (Midade = 31 ± 4 anos) foram divididos em dois grupos [ou seja, treinamento de força explosiva (FE) e controle (CN)], com base em cadeira de rodas de acordo com os escores de classificação da Federação Internacional de Basquetebol em Cadeira de Rodas (IWBF). O grupo FE realizou 6 semanas de treinamento, duas vezes por semana, a 50% de 1RM, 10-12 repetições e 3-4 séries, além de treinamento de rotina. Os efeitos de treinamento foram medidos pelo teste de corrida de 20 metros (sprint test) e pelo teste de agilidade de Illinois.RESULTADOS: O grupo FE mostrou aumentos significantemente maiores de velocidade e desempenho de agilidade (p ≤ 0,05).CONCLUSÃO: A curta duração (isto é, 6 semanas) do programa de treinamento de força explosiva em atletas de basquetebol em cadeira de rodas resulta em melhorias expressivas do desempenho na corrida e de agilidade.

INTRODUCTION: Wheelchair basketball is a paralympic sport characterized by intermittent high-intensity activities that require explosive strength and speed.OBJECTIVE: To investigate the effect of explosive strength training on speed and agility performance in wheelchair basketball players.METHODS: Ten male wheelchair basketball players (Mage=31±4 yrs) were divided into two groups [i.e. explosive strength training (ES); control (CN)] based on International Wheelchair Basketball Federation (IWBF) classification scores. The ES group underwent 6-weeks of training, twice weekly, at 50% 1RM, 10-12 repetitions and 3-4 sets in addition to routine training. Effects of training were measured by the 20 m sprint test and Illinois agility test.RESULTS: The ES group, showed significantly higher increases in speed and agility performance (p ≤ .05).CONCLUSION: A short-duration (i.e. 6-week) explosive strength training programme in wheelchair basketball athletes results in significant improvements in sprint and agility performance.

INTRODUCCIÓN: El básquetbol en silla de ruedas en el deporte paraolímpico caracterizado por actividades intermitentes de alta intensidad, las cuales exigen fuerza explosiva y velocidad.OBJETIVO: Investigar el efecto del entrenamiento de fuerza explosiva sobre la velocidad y el desempeño de la agilidad en jugadores de básquetbol en silla de ruedas.MÉTODOS: Diez jugadores de básquetbol del sexo masculino en silla de ruedas (Promedioedad = 31 ± 4 años) fueron divididos en dos grupos [o sea, entrenamiento de fuerza explosiva (FE) y control (CN)], con base en silla de ruedas, de acuerdo con las puntuaciones de clasificación de la Federación Internacional de Baloncesto en Silla de Ruedas (IWBF). El grupo de FE realizó 6 semanas de entrenamiento, dos veces por semana, a 50% de 1RM, 10-12 repeticiones y 3-4 series, además de entrenamiento de rutina. Los efectos del entrenamiento fueron medidos mediante la prueba de carrera de 20 metros (sprint test) y por la prueba de agilidad de Illinois.RESULTADOS: El grupo de FE mostró aumentos significantemente mayores de velocidad y desempeño de agilidad (p ≤ 0,05).CONCLUSIÓN: La corta duración (es decir, 6 semanas) del programa de entrenamiento de fuerza explosiva, en atletas de básquetbol en silla de ruedas, resultó en mejorías expresivas del desempeño en la carrera y de agilidad.