SUMMARY OBJECTIVE: Thiols play an essential role in eliminating oxidative stress in cells. We aimed to evaluate the oxidative stress occurring during labor with thiol-disulfide balance. METHODS: A total of 97 healthy pregnant women in the 37th–41st gestational weeks who underwent delivery between June 2021 and August 2022 were included in the study. Elective cesarean section group 1 (n=33), vaginal deliveries group 2 (n=29), and cesarean section due to cephalopelvic disproportion group 3 (n=35) were determined. Blood samples were taken before delivery, and from the umbilical artery just after the fetus and placenta were delivered. Serum native thiol (μmol/L), total thiol (μmol/L), and disulfide (μmol/L) were measured. Disulfide/native thiol (%), disulfide/total thiol (%), and native thiol/total thiol (%) ratios were calculated. RESULTS: No significant difference was observed in thiol values in maternal blood (p>0.05). There was a significant difference between the groups in terms of native/total thiol (p=0.017), disulfide/total thiol (%) (p=0.018), and disulfide/native thiol (%) (p=0.018) in cord blood. CONCLUSION: In the literature, evidence concerning the impact of the mode of delivery on the level of neonatal and maternal oxidative stress is inconsistent. It is not clear whether parturition accompanied by pain, as in spontaneous vaginal delivery, poses more oxidative stress than a planned operative delivery. Prospective studies in larger cohorts are needed to better understand the impact of oxidative stress on pregnant women and neonates. OBJECTIVE cells thioldisulfide balance METHODS 9 37th41st thst 37th 41st th st 202 study n=33, n33 n n=33 , 33 (n=33) n=29, n29 n=29 29 (n=29) n=35 n35 35 (n=35 determined delivered μmol/L, μmolL μmol/L μmol L (μmol/L measured Disulfidenative Disulfide %, % disulfidetotal thioltotal (% calculated RESULTS p>0.05. p005 p p>0.05 . 0 05 (p>0.05) nativetotal p=0.017, p0017 p=0.017 017 (p=0.017) p=0.018, p0018 p=0.018 018 disulfidenative (p=0.018 CONCLUSION literature inconsistent pain neonates 20 n3 n=3 (n=33 n2 n=2 (n=29 (n=3 ( p00 p>0.0 (p>0.05 p001 p=0.01 01 (p=0.017 (p=0.01 n= (n=2 (n= p0 p>0. (p>0.0 p=0.0 (p=0.0 (n p>0 (p>0. p=0. (p=0. p> (p>0 p=0 (p=0 (p> p= (p= (p

SUMMARY OBJECTIVE: The present study compares the cardiac parameters of the survivor and nonsurvivor patients with COVID-19 infection. METHODS: This study was conducted in 379 patients diagnosed with COVID-19 disease. Information of 21 nonsurvivor and 358 survivor patients with COVID-19 was obtained from the hospital information management system and analyzed retrospectively. Relationship between cardiac parameters in patients categorized into the mortal and immortal groups was investigated. RESULTS: Of the total 379 patients involved in this study, 155 (40.9%) were females and 224 (59.1%) were males. No statistically significant difference in mortality was found between females and males (p=0.249). The total median age was 70, the median age in the nonsurvivor group was 74 (35–89), and it was 69.5 (18–96) in the survivor group (p=0.249). The median values of high-sensitivity troponin (hs-Tn), creatine kinase MB form, and especially myoglobin in the survivor and nonsurvivor groups were 25/64.9 (p=0.028), 18/23 (p=0.02), and 105.5/322.4 (p<0.001), and the difference was statistically significant. Comparing mortality, while there was 1 (0.7%) nonsurvivor out of 134 patients in the service unit, there were 20 (8.2%) nonsurvivors out of 245 patients in the intensive care unit. This difference was statistically significant (p=0.003). The cutoff value of myoglobin, which may pose a risk of mortality, was found to be 191.4 µg/L, while it was 45.7 ng/l for hs-Tn and 60.1 U/L for creatine kinase MB. CONCLUSIONS: Advanced age and increased levels of high-sensitivity troponin, creatine kinase MB, and myoglobin were found to be associated with mortality.