Abstract Superior mesenteric artery syndrome (SMAS) is a rare cause of duodenal obstruction which is characterized by compression of the duodenum due to narrowing of the space between the superior mesenteric artery and aorta. Incomplete duodenal obstruction due to SMAS in neonates is rarely reported in the literature. In this case, it is a full-term 2-day-old male with the complaint of recurrent vomiting starting soon after birth. The patient was diagnosed with SMAS and duodenoduodenostomy was performed. Accompanying Meckel’s diverticulum was excised.

Resumen El síndrome de la arteria mesentérica superior (SMAS) es una causa rara de obstrucción duodenal que se caracteriza por la compresión del duodeno debido al estrechamiento del espacio entre la arteria mesentérica superior y la aorta. La obstrucción duodenal incompleta por SMAS en recién nacidos rara vez se informa en la literatura. En este caso se trata de un varón de 2 días nacido a término que presenta vómitos recurrentes desde poco después del nacimiento. El paciente fue diagnosticado de SMAS y se le realizó duodenoduodenostomía. Se extirpó el divertículo de Meckel que lo acompañaba.

SUMMARY OBJECTIVE: The objective of this study was to assess the effectiveness and safety of levosimendan as an alternative treatment for pediatric patients with decompensated heart failure unresponsive to conventional inotropes and to emphasize its role in enhancing cardiovascular stability. METHODS: A total of 15 pediatric patients with decompensated heart failure, stemming from acute fulminant myocarditis (53.3%) and post-congenital heart disease surgery complications (46.7%), received levosimendan. The evaluation focused on adverse effects, respiratory support requirements, and concurrent inotropic medication use during levosimendan treatment. Key cardiovascular parameters were assessed at 0, 6, 12, and 24 h post-levosimendan infusion. RESULTS: Levosimendan administration significantly improved key cardiovascular metrics. Left ventricular ejection fraction increased notably from 45±14.8% to 58±15.6% at 24 h (p<0.001). Systolic and diastolic blood pressures rose significantly, with systolic increasing from 79 (68–90) to 98 (89–109) mmHg and diastolic from 47 (40–57) to 66 (54–76) mmHg by 24 h (p<0.001). Heart rate decreased from 162 (111–175) to 132 (99–148) bpm (p=0.02), and lactate levels significantly decreased from 4.15 (2.3–6.5) to 1.85 (0.8–2.6) mmol/L within 6 h (p<0.001). CONCLUSION: Levosimendan demonstrates its significance in managing pediatric heart failure, indicating its safety and potential to enhance cardiac outcomes by reducing reliance on traditional inotropes. OBJECTIVE stability METHODS 1 53.3% 533 53 3 (53.3% postcongenital post congenital 46.7%, 467 46.7% , 46 7 (46.7%) effects requirements 0 12 2 postlevosimendan infusion RESULTS metrics 45148 45 14 8 45±14.8 58156 58 58±15.6 p<0.001. p0001 p p<0.001 . 001 (p<0.001) 68–90 6890 68 90 (68–90 9 89–109 89109 89 109 (89–109 4 40–57 4057 40 57 (40–57 54–76 5476 54 76 (54–76 16 111–175 111175 111 175 (111–175 13 99–148 99148 99 148 (99–148 p=0.02, p002 p=0.02 02 (p=0.02) 415 4.1 2.3–6.5 2365 5 (2.3–6.5 185 85 1.8 0.8–2.6 0826 (0.8–2.6 mmolL mmol L CONCLUSION 53.3 (53.3 46.7 (46.7% 4514 45±14. 5815 58±15. p000 p<0.00 00 (p<0.001 68–9 689 (68–9 89–10 8910 10 (89–10 40–5 405 (40–5 54–7 547 (54–7 111–17 11117 11 17 (111–17 99–14 9914 (99–14 p00 p=0.0 (p=0.02 41 4. 2.3–6. 236 (2.3–6. 18 1. 0.8–2. 082 (0.8–2. 53. (53. 46. (46.7 451 45±14 581 58±15 p<0.0 (p<0.00 68– (68– 89–1 891 (89–1 40– (40– 54– (54– 111–1 1111 (111–1 99–1 991 (99–1 p0 p=0. (p=0.0 2.3–6 23 (2.3–6 0.8–2 08 (0.8–2 (53 (46. 45±1 58±1 p<0. (p<0.0 (68 89– (89– (40 (54 111– (111– 99– (99– p=0 (p=0. 2.3– (2.3– 0.8– (0.8– (5 (46 45± 58± p<0 (p<0. (6 (89 (4 (111 (99 p= (p=0 2.3 (2.3 0.8 (0.8 ( p< (p<0 (8 (11 (9 (p= 2. (2. 0. (0. (p< (1 (p (2 (0

Abstract Objective: In this study, we created an animal model to demonstrate the effects of thiamine on the hearing pathways of new-borns during pregnancy and lactation by inducing a dietary thiamine deficiency in the mother. Methods: The study included 16 female Wistar albino rats. The animals were separated into four groups and provided the appropriate amounts of dietary thiamine according to their groups during pre-pregnancy, pregnancy, and lactation periods. Three pups from each mother were included in the study, and 12 pups were selected from each group. On the fortieth day after birth, the auditory pathways of 48 pups in the 4 groups were examined electro physiologically and ultra-structurally. Results: In Group N-N, morphology of hair cells stereocilia degeneration was not obtained in all turns of cochlea. In Group N-T, Inner Hair Cells (IHCs) and Outher Hair Cells (OHCs) stereocilia didn’t show degeneration in all turns of cochlea but had rupture inrows of HCs stereocilia. In group T-N IHCs stereocilia less degeneration was observed in all turns of cochlea. OHC stereocilia partial loss was observed only in basal turn of cochlea. In Group T-T IHCs stereocilia was observed less degeneration and rupture in all turns of cochlea. Conclusion: Thiamine is vital for the development of cochlear hair cells during both prenatal and postnatal periods. Even partial deficiency of thiamine causes significant degeneration to the auditory pathway. Level of evidence: The level of evidence of this article is 5. This article is an experimental animal and laboratory study. Objective newborns new borns Methods 1 rats prepregnancy, prepregnancy pre pre-pregnancy periods birth ultrastructurally. ultrastructurally ultra structurally. structurally ultra-structurally Results NN, NN N N, N-N NT, NT T, T N-T (IHCs OHCs (OHCs didnt didn t TN TT Conclusion pathway 5

Abstract Objectives: the current study evaluated the orthorexic tendencies of social media users and the factors affecting these tendencies. Methods: a total of 2526 adult participants (696 male and 1830 female, 28.4 ± 10.3 years) completed a questionnaire that includes personal information, the Orthorexia Nervosa Scale (ORTO-11), the Social Media and Eating Behavior Scale (SMEB), and the International Physical Activity Questionnaire Short Form (IPAQ). Body mass index (BMI) was calculated from the reported weight and height of the participants. Independent-sample t-tests or chi-square tests were computed to evaluate various information of the participants according to the ON tendency. A binary logistic regression analysis was used to identify risk factors. Results: according to ORTO-11, 56.1 % of the participants had a tendency to ON, and the trend to ON increased with age and BMI (p < 0.05). People without ON tendency spent more time (172.2 ± 119.9 min/day) on social media. Participants who followed webpages with healthy nutrition and sport-exercise recommendations had an increased ON risk when compared to those who did not follow those pages (p < 0.05). In addition, although there was a significant difference between participants in physical activity level according to the ON tendency, this relationship was not significant in the regression model (p > 0.05). Conclusion: this study indicates that increasing social media usage, especially web pages that include health and nutrition recommendations, may boost the tendency to ON. Thus, raising awareness of social media may be beneficial to people who have a tendency to ON.

Resumen Objetivos: el presente estudio evaluó las tendencias ortoréxicas de los usuarios de las redes sociales y los factores que afectan a estas tendencias. Métodos: un total de 2526 participantes adultos (696 hombres y 1830 mujeres, 28,4 ± 10,3 años de edad) completaron un cuestionario que incluye información personal, la escala de ortorexia nerviosa (ORTO-11), la escala de redes sociales y conducta alimentaria (SMEB) y el cuestionario internacional de actividad física en formato corto (IPAQ). El índice de masa corporal (IMC) se calculó a partir del peso y la estatura declarados por los participantes. Se realizaron pruebas t o pruebas del chi cuadrado de muestras independientes para evaluar la diversa información de los participantes según la tendencia a la ortorexia nerviosa. Se utilizó un análisis de regresión logística binaria para identificar los factores de riesgo. Resultados: según el ORTO-11, el 56,1 % de los participantes tenían tendencia a la ortorexia nerviosa y esta tendencia aumentaba con la edad y el IMC (p < 0,05). Las personas sin tendencia a la ortorexia nerviosa dedicaban más tiempo (172,2 ± 119,9 min/día) a las redes sociales. Los participantes que seguían páginas web con recomendaciones sobre alimentación saludable y deporte/ejercicios tenían un mayor riesgo de ortorexia nerviosa que los que no seguían esas páginas (p < 0,05). Además, aunque había una diferencia significativa entre los niveles de actividad física de los participantes según la tendencia a la ortorexia nerviosa, esta relación no era significativa en el modelo de regresión (p > 0,05). Conclusión: este estudio indica que el incremento del uso de las redes sociales, especialmente de las páginas web que incluyen recomendaciones sobre salud y alimentación, podría favorecer la tendencia a la ortorexia nerviosa. Por lo tanto, concienciar a las personas con tendencia a la ortorexia nerviosa sobre las redes sociales puede tener un efecto beneficioso.

SUMMARY OBJECTIVE: In this article, we investigated the association of chromogranin A with coronary artery disease. METHODS: Biochemical parameters and chromogranin A levels obtained from peripheral blood samples during coronary angiography were analyzed in 90 patients. Patients were classified into two groups, namely, SYNergy between PCI with TAXUS and Cardiac Surgery score ≥1 (n=45) and SYNergy between PCI with TAXUS and Cardiac Surgery score=0 (n=45). This is a cross-sectional, prospective study. RESULTS: Serum chromogranin A levels were significantly higher in the group with SYNergy between PCI with TAXUS and Cardiac Surgery score ≥1 compared to the group with SYNergy between PCI with TAXUS and Cardiac Surgery score=0 (1381.5±418.9 ng/mL and 1121.2±290.7 ng/mL, respectively; p=0.002). Serum chromogranin A levels were correlated with SYNergy between PCI with TAXUS and Cardiac Surgery score (r=0.556, p<0.04). ROC analysis showed that the area under the curve for serum chromogranin A levels was 0.687 (p=0.007), and the best cutoff value of 1,131 ng/mL had a sensitivity of 67% and a specificity of 65% for the prediction of coronary artery disease. CONCLUSION: Serum chromogranin A levels were increased in coronary artery disease patients with SYNergy between PCI with TAXUS and Cardiac Surgery score ≥1. Increasing serum chromogranin A levels are proportional to the SYNergy between PCI with TAXUS and Cardiac Surgery score. OBJECTIVE article METHODS 9 groups namely 1 ≥ n=45 n45 n 45 (n=45 score0 0 score= n=45. . crosssectional, crosssectional cross sectional, sectional cross-sectional study RESULTS 1381.5±418.9 138154189 1381 5 418 (1381.5±418. ngmL ng mL 112122907 1121 2 290 7 1121.2±290. respectively p=0.002. p0002 p p=0.002 002 p=0.002) r=0.556, r0556 r 556 (r=0.556 p<0.04. p004 p<0.04 04 p<0.04) 0687 687 0.68 p=0.007, p0007 p=0.007 , 007 (p=0.007) 1131 131 1,13 67 65 CONCLUSION n=4 n4 4 (n=4 1381.5±418. 13815418 138 41 (1381.5±418 11212290 112 29 1121.2±290 p000 p=0.00 00 r=0.556 r055 55 (r=0.55 p00 p<0.0 068 68 0.6 (p=0.007 113 13 1,1 6 n= (n= 1381.5±418 1381541 (1381.5±41 1121229 11 1121.2±29 p=0.0 r=0.55 r05 (r=0.5 p0 p<0. 06 0. (p=0.00 1, (n 1381.5±41 138154 (1381.5±4 112122 1121.2±2 p=0. r=0.5 r0 (r=0. p<0 (p=0.0 1381.5±4 13815 (1381.5± 11212 1121.2± p=0 r=0. (r=0 p< (p=0. 1381.5± (1381.5 1121.2 p= r=0 (r= (p=0 1381.5 (1381. 1121. r= (r (p= 1381. (1381 (p (138 (13 (1 (

Abstract: While Fibre-Reinforced Plastics are lightweight, show a high tensile strength, and have no issue with corrosion, they are unfortunately brittle and perform poorly against temperature. Therefore, it is important to know the time and magnitude of the temperature reaching the bars in the high-temperature effect of FRPs produced in the form of bar in reinforced concrete structural elements in concrete. This study set out to examine the time and temperature values of glass fiber reinforced polymer (GFRP) reinforced concrete under high-temperatures. The effects of concrete cover thickness and concrete strength on temperature transfer were researched experimentally. GFRP bars were placed in specimens prepared in three concrete strengths and three different concrete cover thicknesses (20-40-60 mm) exposed to temperature, and temperature-time graphs were created by measuring bar temperature, concrete surface temperature and ambient temperature. The critical time to a glass transition temperature, and optimum cover thickness of GFRPs according to concrete strength and concrete cover thickness were discussed. The study results appeared to indicate that the thickness of the concrete cover is very effective in protecting the bar against temperature in reinforced concrete structural elements, as concrete strength, itself, has only a limited effect.

Abstract Background Gelastic seizures are extremely rare, short-lasting, unprovoked, and uncontrollable laughing attacks. We conducted this retrospective evaluation to determine whether these symptoms, manifesting in different forms, such as cheerful laughter, laughing, smiling, and sobbing had any value in terms of etiology or localization. Methods A total of 31 patients who exhibited bouts of laughing or crying and who were under follow-up between 2000 and 2019 at tertiary epilepsy centers were included in the study. Laughing seizures were divided into three groups in terms of semiology (i.e., laughter with mirth, laughter without mirth, and smile). Dacrystic seizures were accompanied by some gelastic seizures and were divided into two groups in terms of semiology (i.e., weeping loudly [motor and voice-sobbing] and crying). Results Of the 27 patients with laughing seizures, 12 had seizures that manifested with smiling, 7 had seizures that manifested with laughing and mirth, and 8 had seizures that manifested with laughter without mirth. Dacrystic-gelastic seizures were observed in four patients, among whom 2 patients had crying and laughter without mirth and 2 patients had weeping loudly and laughter without mirth episodes. Conclusion Gelastic and dacrystic seizures often suggest hypothalamic hamartomas, in the literature. This rare ictal behavior can originate from different cortical locations and lesions of a different nature. However, we found that gelastic seizures with smiling were a more homogenous group with regard to location in the temporal lobe, which we aimed to show by evaluating the patients included in this study. shortlasting, shortlasting short lasting, lasting short-lasting unprovoked attacks symptoms forms localization 3 followup follow up 200 201 study i.e., ie i e (i.e. smile. smile . smile) motor voicesobbing voice voice-sobbing crying. crying) 1 Dacrysticgelastic episodes hamartomas literature nature However lobe 20 i.e. (i.e i.e

Resumo Antecedentes Crises gelásticas são ataques de riso extremamente raros, de curta duração, não provocados e incontroláveis. Realizamos esta avaliação retrospectiva para determinar se esses sintomas, manifestando-se de diferentes formas, como riso alegre, riso, sorriso e soluço, tinham algum valor em termos de etiologia ou localização. Métodos Foram incluídos no estudo 31 pacientes que apresentavam crises de riso ou choro e que estavam em acompanhamento entre 2000 e 2019 em centros terciários de epilepsia. As crises de riso foram divididas em três grupos em termos de semiologia (ou seja, riso com alegria, riso sem alegria e sorriso). As crises dacrísticas foram acompanhadas por algumas crises gelásticas e foram divididas em dois grupos em termos de semiologia (ou seja, choro alto [motor e soluçar a voz] e choro). Resultados Dos 27 pacientes com crises de riso, 12 tiveram crises que se manifestaram com sorriso, 7 tiveram crises que se manifestaram com riso e alegria e 8 tiveram crises que se manifestaram com riso sem alegria. Crises dácristico-gelásticas foram observadas em quatro pacientes, sendo 2 pacientes com choro e riso sem alegria e 2 pacientes com choro alto e riso sem alegria. Conclusão Crises gelásticas e dacrísticas frequentemente sugerem hamartomas hipotalâmicos, na literatura. Este comportamento ictal raro pode ter origem em diferentes localizações corticais e lesões de natureza diversa. No entanto, verificamos que as crises gelásticas com sorriso foram um grupo mais homogêneo quanto à localização no lobo temporal, o que buscamos evidenciar avaliando os pacientes incluídos neste estudo. raros duração incontroláveis sintomas manifestandose manifestando formas alegre soluço 3 200 201 epilepsia seja sorriso. . sorriso) motor voz choro. choro) 1 dácristicogelásticas dácristico hipotalâmicos literatura diversa entanto temporal 20

Objective: Bipolar I disorder (BD-I) is a type of bipolar spectrum disorder characterized by manic or mixed episodes. Detecting microRNA regulations as epigenetic actors in BD-I is important to elucidate the pathogenesis of the disease and reveal the potential of microRNAs (miRNAs) as biomarkers. Methods: We evaluated the expression profile of six candidate miRNAs (hsa-miR-145-5p, hsa-miR-376a-3p, hsa-miR-3680-5p, hsa-miR-4253-5p, hsa-miR-4482-3p, and hsa-miR-4725) in patients with BD-I and in healthy controls (aged 11-50 years). We also determined the potential target genes of these miRNAs through in silico analysis. The diagnostic values of the miRNAs were calculated through receiver operating characteristic curve analysis. Results: Four miRNAs were upregulated (hsa-miR-376a-3p, hsa-miR-3680-5p, hsa-miR-4253-5p, hsa-miR-4482-3p) and hsa-miR-145-5p was downregulated in patients (p < 0.001). The target gene analyses showed that hsa-miR-145-5p specifically targets the dopamine decarboxylase (DDC) gene. The area under the curve of hsa-miR-145-5p was 0.987. Conclusion: Differential expression of five miRNAs in peripheral blood may be associated with the pathogenesis of BD-I, and hsa-miR-145-5p has potential as a BD-I biomarker. This miRNA can be used in dopamine-serotonin regulation and dose adjustment in drug therapy via the DDC gene.

Abstract Objectives: Ischemia-reperfusion injury is an important cause of multiple organ failure in cardiovascular surgery. Our aim is to investigate the effect of the probiotic Saccharomyces boulardii on oxidative stress, inflammatory response, and lung injury in an experimental model of aortic clamping. Methods: Twenty-one Wistar rats were randomized into three groups (n=7). Control group animals received saline gavage for a week before undergoing median laparotomy. In other groups, supraceliac aorta was clamped for 45 minutes to induce ischemia followed by reperfusion for 60 minutes. In the ischemia-reperfusion group, saline gavage was given preoperatively for one week. Ischemia-reperfusion+probiotic group rats received probiotic gavage for seven days before aortic clamping. The levels of oxidative stress markers and pro-inflammatory cytokines were determined in both serum and lung tissue samples. Ileum and lung tissues were harvested for histological examination. Results: Ischemia-reperfusion caused severe oxidative damage and inflammation evident by significant increases in malondialdehyde and cytokine levels (tumor necrosis factor alpha and interleukin-1 beta) and decreased glutathione levels in both serum and lung tissues. There was severe histological tissue damage to the lung and ileum in the ischemia-reperfusion group. Probiotic pretreatment before aortic clamping caused significant suppression of increases in serum and lung tissue malondialdehyde and tumor necrosis factor alpha levels. Histological damage scores in tissue samples decreased in the ischemia-reperfusion+probiotic group (P<0,005). Conclusions: Oral supplementation of probiotic S. boulardii before supraceliac aortic ischemia-reperfusion in rats alleviates lung injury by reducing oxidative stress, intestinal cellular damage, and modulation of inflammatory processes. Objectives Ischemiareperfusion Ischemia surgery response Methods Twentyone Twenty n=7. n7 n n=7 . 7 (n=7) laparotomy 4 6 ischemiareperfusion Ischemiareperfusion+probiotic Ischemiareperfusionprobiotic reperfusion+probiotic proinflammatory pro examination Results interleukin1 interleukin 1 interleukin- beta ischemiareperfusion+probiotic ischemiareperfusionprobiotic P<0,005. P0005 P P<0,005 0 005 (P<0,005) Conclusions S processes n= (n=7 reperfusionprobiotic P000 P<0,00 00 (P<0,005 (n= P00 P<0,0 (P<0,00 (n P0 P<0, (P<0,0 P<0 (P<0, P< (P<0 (P< (P

Abstract Objective To investigate the effect of closure types of the anterior abdominal wall layers in cesarean section (CS) surgery on early postoperative findings. Methods The present study was designed as a prospective cross-sectional study and was conducted at a university hospital between October 2018 and February 2019. A total of 180 patients who underwent CS for various reasons were enrolled in the study. Each patient was randomly assigned to one of three groups: Both parietal peritoneum and rectus abdominis muscle left open (group 1), parietal peritoneum closure only (group 2), and closure of the parietal peritoneum and reapproximation of rectus muscle (group 3). All patients were compared in terms of postoperative pain scores (while lying down and duringmobilization), analgesia requirement, and return of bowel motility. Results The postoperative pain scores were similar at the 2nd, 6th, 12th, and 18th hours while lying down. During mobilization, the postoperative pain scores at 6 and 12 hours were significantly higher in group 2 than in group 3. Diclofenac use was significantly higher in patients in group 1 than in those in group 2. Meperidine requirements were similar among the groups. There was no difference between the groups’ first flatus and stool passage times. Conclusion In the group with only parietal peritoneum closure, the pain scores at the 6th and 12th hours were higher. Rectus abdominismuscle reapproximations were found not to increase the pain score. The closure of the anterior abdominal wall had no effect on the return of bowel motility.

Resumo Introdução A cefaleia por ponto de contato da mucosa é uma dor direcionada que surge do contato entre o septo nasal e a parede nasal lateral. Evidências corroboram o papel da substância P na cefaleia de contato, de tal forma que a liberação da mesma a partir de terminações nervosas sensoriais possa causar inflamação e alergia. Objetivo Determinar possíveis diferenças nos níveis da substância P na hipertrofia de conchas inferiores em relação à cefaleia de contato. Método Foram incluídos no estudo 28 pacientes que apresentaram cefaleia por ponto de contato (Grupo Estudo) e 16 voluntários sem queixas. Os níveis de substância P nas amostras de tecido da concha inferior foram quantificados com um kit substância P EIA, comercialmente disponível. Resultados No grupo do estudo, os níveis médios de substância P foram 2,65 ± 0,27 pg/mg de tecido (variação: 0,61-5,44) e no grupo controle foram de 1,77 ± 0,27 pg/mg de tecido (variação: 0,11-4,35) e a diferença foi estatisticamente significante entre os dois grupos (p = 0,0215). O escore médio da escala visual analógica do grupo de cefaleia pré-operatória foi de 5,93 ± 0,38 (2-9) e o volume das conchas foi de 6,56 ± 0,35 cm3 (3,50-10,30). O volume da concha do grupo controle foi de 4,71 ± 0,39 cm3 (2,50 ± 7,70). Encontramos uma correlação entre o escore da escala visual analógica e os níveis de substância P, de modo que os níveis de substância P foram maiores nos escores da escala visual analógica acima de 5 (p = 0,001). Conclusão Este estudo demonstra a relação entre cefaleias por contato intranasais e níveis aumentados de substância P nas mucosas. Também observamos que não há correlação com os níveis de substância P e o volume da concha inferior.

Abstract Introduction Mucosal contact headache is a referred pain that arises from contact between the nasal septum and the lateral nasal wall. Evidence supports the role of substance P in a contact headache such that release of substance P from sensory nerve endings causes inflammation and allergy. Objectives This study aimed to determine possible differences in substance P levels in inferior turbinate hypertrophy creating a contact headache. Methods 28 patients who had contact headaches (study group) and 16 volunteers with no complaints were included in the study. Substance P levels in the inferior turbinate tissue samples were quantified using a commercially available substance P EIA kit. Results In the study group average substance P levels were 2.65 ± 0.27 pg/mg tissue (range: 0.61–5.44) and in the control group it was 1.77 ± 0.27 pg/mg tissue (range: 0.11–4.35). The difference was statistically significant between the two groups (p = 0.0215). Average preoperative headache group visual analog scale scores was 5.93 ± 0.38 (2–9) and the turbinate volume was 6.56 ± 0.35 cm3 (3.50–10.30). The control group turbinate volume was 4.71 ± 0.39 cm3 (2.50–7.70). We found a correlation between the visual analog scale scores and substance P levels such that substance P levels were higher in visual analog scale scores above 5 (p = 0.001). Conclusion This study demonstrates the relationship between intranasal contact headaches and increased mucosal substance P levels. We also found that there is no correlation with substance P levels and volume of the inferior turbinate.

Abstract Purpose To investigate the effects of adalimumab pretreatment on the lipopolysaccharide-mediated myocardial injury. Methods Twenty-eight Wistar rats were randomized into four groups (n=7). Control (C) group animals were injected once a day with intraperitoneal (i.p) 0.9 % saline for two days. In the Adalimumab (Ada) group, adalimumab was injected at a dose of 10 mg/kg/ day (i.p) for two days. Lipopolysaccharide (Lps) group rats were injected with a dose of 5 mg/kg (i.p) lipopolysaccharide. Lipopolysaccharide + Adalimumab (Lps+Ada) group rats received adalimumab before the administration of lipopolysaccharide. The animals were sacrificed 24 h after the last injection and blood samples were obtained for determination of biochemical cardiac injury markers and circulating levels of TNF-α and interleukin-6 (IL-6). Hearts were harvested for histological examination. Results Endotoxin exposure resulted in significant increases in serum cardiac injury markers, serum cytokines and histological myocardial injury scores in the Lps group. The levels of circulating cytokines, cardiac injury markers and histological injury scores for myocardial necrosis, perivascular cell infiltration, and inflammation were significantly reduced in Lps+Ada as compared to Lps group (p<0.05). Conclusions Adalimumab pretreatment reduces endotoxin-induced myocardial damage in rats. This beneficial effect is thought to be related to the reduction of cytokine release.

Abstract INTRODUCTION: Nosocomial and community acquired urinary tract infections (UTIs) are one of the most encountered infections in the world. METHODS: This study aimed to determine the antibiotic susceptibility, phylogeny, and virulence genes of 153 Escherichia coli strains isolated from UTIs. Antimicrobial susceptibility of the isolates to different classes of antimicrobials was determined by the VITEK-2 automated system. Presence of virulence genes and phylogenetic groups were investigated by PCR. RESULTS: Regarding susceptibility to antimicrobials, ampicillin resistance was most abundant (67.3%), followed by amoxicillin-clavulanic acid (50.9%); least abundant was resistance to amikacin (1.3%) and nitrofurantoin (1.3%). Multi drug resistance (MDR) was observed in 34.6% of the isolates, and all isolates were found to be susceptible to imipenem, meropenem and fosfomycine. The majority of the isolates belonged to the phylogenetic group B23 (35.9%), followed by A1 (20.9%), D1 (18.9%), D2 (12.4%), A0 (%5.9), B1 (3.9%) and B2 (1.9%). Among E. coli strains examined, 49% had iucD, 32.7% papE-F, 26.1% papC, 15% cnf2, 11.1% sfa, 7.8% cnf1, 1.3% afaE, 1.3% afaD, 1.3% hlyA, 0.7% f17a-A, 0.7% clpG and 0.7% eaeA genes. CONCLUSIONS Our research demonstrated that virulence factors were distributed among different phylogroup/subgroups, which play a role in UTIs pathogenesis in humans. For this reason, complex and detailed studies are required to determine the relationship between virulence factors and specific E. coli strains that cause UTIs in humans.