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ABSTRACT Introduction: Pulmonary artery denervation (PADN) can reduce the sympathetic nervous system (SNS) activity, reduce pulmonary artery pressure (PAP), and improve the quality of life in patients with pulmonary hypertension (PH). We conducted a systematic meta-analysis of the effectiveness of PADN in the treatment of PH patients. Methods: This is a comprehensive literature search including all public clinical trials investigating the effects of PADN on PH. Outcomes were mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR), cardiac output (CO), right ventricular (RV) Tei index, 6-minute walk distance (6MWD), and New York Heart Association (NYHA) cardiac function grading. Results: A total of eight clinical studies with 213 PH patients who underwent PADN were included. Meta-analysis showed that after PADN, mPAP (mean difference [MD] -12.51, 95% confidence interval [CI] -17.74 to -7.27, P<0.00001) (mmHg) and PVR (MD -5.17, 95% CI -7.70 to -2.65, P<0.0001) (Wood unit) decreased significantly, CO (MD 0.59, 95% CI 0.32 to 0.86, P<0.0001) (L/min) and 6MWD (MD 107.75, 95% CI 65.64 to 149.86, P<0.00001) (meter) increased significantly, and RV Tei index (MD -0.05, 95% CI -0.28 to 0.17, P=0.63) did not change significantly. Also after PADN, the proportion of NYHA cardiac function grading (risk ratio 0.23, 95% CI 0.14 to 0.37, P<0.00001) III and IV decreased significantly. Conclusion: This meta-analysis supports PADN as a potential new treatment for PH. Further high-quality randomized controlled studies are needed. Introduction (PADN SNS (SNS activity PAP, PAP , (PAP) . (PH) metaanalysis meta analysis Methods mPAP, (mPAP) PVR, (PVR) CO, (CO) (RV 6minute minute 6 6MWD, MWD (6MWD) (NYHA Results 21 included Metaanalysis Meta MD [MD 12.51, 1251 12 51 -12.51 95 [CI 17.74 1774 17 74 -17.7 7.27, 727 7 27 -7.27 P<0.00001 P000001 P 0 00001 mmHg (mmHg 5.17, 517 5 -5.17 7.70 770 70 -7.7 2.65, 265 2 65 -2.65 P<0.0001 P00001 0001 Wood unit significantly 059 59 0.59 032 32 0.3 086 86 0.86 L/min Lmin L min (L/min 10775 107 75 107.75 6564 64 65.6 14986 149 149.86 meter (meter 0.05, 005 05 -0.05 0.28 028 28 -0.2 017 0.17 P=0.63 P063 63 risk 023 23 0.23 014 14 0.1 037 37 0.37 Conclusion highquality high needed (PAP (PH (mPAP (PVR (CO (6MWD 12.51 125 1 -12.5 9 17.7 177 -17. 7.27 72 -7.2 P<0.0000 P00000 0000 5.17 -5.1 7.7 77 -7. 2.65 26 -2.6 P<0.000 P0000 000 0.5 03 3 0. 08 8 0.8 1077 10 107.7 656 65. 1498 149.8 0.05 00 -0.0 0.2 02 -0. 01 P=0.6 P06 12.5 -12. 17. -17 7.2 5.1 -5. 7. -7 2.6 -2. P<0.00 P000 107. 149. 0.0 -0 P=0. P0 12. -12 -1 5. -5 - 2. -2 P<0.0 P00 P=0 P<0. P= P<0 P<