ABSTRACT Introduction: Ventricular septal rupture is an important high-mortality complication in the scope of myocardial infarctions. The effectiveness of different treatment modalities is still controversial. This meta-analysis compares the efficacy of percutaneous closure vs. surgical repair for the treatment of postinfarction ventricular septal rupture (PI-VSR). Methods: A meta-analysis was performed on relevant studies found through PubMed®, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (or CNKI), Wanfang Data, and VIP databases searching. The primary outcome was a comparison of in-hospital mortality between the two treatments, and the secondary outcome was documentation of one-year mortality, postoperative residual shunts, and postoperative cardiac function. Differences were expressed as odds ratios (ORs) with 95% confidence intervals (CIs) to assess the relationships between predefined surgical variables and clinical outcomes. Results: Qualified studies (742 patients from 12 trials) were found and investigated for this meta-analysis (459 patients in the surgical repair group, 283 patients in the percutaneous closure group). When comparing surgical repair to percutaneous closure, it was found that the former significantly reduced in-hospital mortality (OR: 0.67, 95% CI 0.48-0.96, P=0.03) and postoperative residual shunts (OR: 0.03, 95% CI 0.01-0.10, P<0.00001). Surgical repair also improved postoperative cardiac function overall (OR: 3.89, 95% CI 1.10-13.74, P=0.04). However, there was no statistically significant difference in one-year mortality between the two surgical strategies (OR: 0.58, 95% CI 0.24-1.39, P=0.23). Conclusion: We found that surgical repair appears to be a more effective therapeutic option than percutaneous closure for PI-VSR.

ABSTRACT Introduction: Ventricular septal rupture is an important high-mortality complication in the scope of myocardial infarctions. The effectiveness of different treatment modalities is still controversial. This meta-analysis compares the efficacy of percutaneous closure vs. surgical repair for the treatment of postinfarction ventricular septal rupture (PI-VSR). Methods: A meta-analysis was performed on relevant studies found through PubMed®, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (or CNKI), Wanfang Data, and VIP databases searching. The primary outcome was a comparison of in-hospital mortality between the two treatments, and the secondary outcome was documentation of one-year mortality, postoperative residual shunts, and postoperative cardiac function. Differences were expressed as odds ratios (ORs) with 95% confidence intervals (CIs) to assess the relationships between predefined surgical variables and clinical outcomes. Results: Qualified studies (742 patients from 12 trials) were found and investigated for this meta-analysis (459 patients in the surgical repair group, 283 patients in the percutaneous closure group). When comparing surgical repair to percutaneous closure, it was found that the former significantly reduced in-hospital mortality (OR: 0.67, 95% CI 0.48-0.96, P=0.03) and postoperative residual shunts (OR: 0.03, 95% CI 0.01-0.10, P<0.00001). Surgical repair also improved postoperative cardiac function overall (OR: 3.89, 95% CI 1.10-13.74, P=0.04). However, there was no statistically significant difference in one-year mortality between the two surgical strategies (OR: 0.58, 95% CI 0.24-1.39, P=0.23). Conclusion: We found that surgical repair appears to be a more effective therapeutic option than percutaneous closure for PI-VSR. Introduction highmortality high infarctions controversial metaanalysis meta analysis vs PIVSR. PIVSR PI VSR . (PI-VSR) Methods PubMed PubMed® Embase Science Library or CNKI, CNKI , CNKI) Data searching inhospital hospital treatments oneyear one year ORs (ORs 95 CIs (CIs outcomes Results 742 (74 1 trials 459 (45 group 28 group. group) OR (OR 067 0 67 0.67 0.480.96, 048096 0.48 0.96, 48 96 0.48-0.96 P=0.03 P003 P 03 003 0.03 0.010.10, 001010 0.01 0.10, 01 10 0.01-0.10 P<0.00001. P000001 P<0.00001 00001 P<0.00001) 389 3 89 3.89 1.1013.74, 1101374 1.10 13.74, 13 74 1.10-13.74 P=0.04. P004 P=0.04 04 P=0.04) However 058 58 0.58 0.241.39, 024139 0.24 1.39, 24 39 0.24-1.39 P=0.23. P023 P=0.23 23 P=0.23) Conclusion VSR. PI-VSR (PI-VSR 9 (7 45 (4 2 06 6 0.6 480 0.480.96 04809 048 0.4 096 0.96 4 0.48-0.9 P=0.0 P00 00 0.0 010 0.010.10 00101 001 0.10 0.01-0.1 P00000 P<0.0000 0000 38 8 3.8 1013 1.1013.74 110137 110 1.1 1374 13.74 7 1.10-13.7 05 5 0.5 241 0.241.39 02413 024 0.2 139 1.39 0.24-1.3 P02 P=0.2 ( 0. 0.480.9 0480 09 0.9 0.48-0. P=0. P0 0.010.1 0010 0.1 0.01-0. P0000 P<0.000 000 3. 101 1.1013.7 11013 11 1. 137 13.7 1.10-13. 0.241.3 0241 02 1.3 0.24-1. 0.480. 0.48-0 P=0 0.010. 0.01-0 P000 P<0.00 1.1013. 1101 13. 1.10-13 0.241. 0.24-1 0.480 0.48- P= 0.010 0.01- P<0.0 1.1013 1.10-1 0.241 0.24- P<0. 1.101 1.10- P<0 P<

Abstract Background Alpha-kinase 1 (ALPK1) is a master regulator in inflammation and has been proved to promote renal fibrosis by promoting the production of IL-1β in diabetic nephropathy (DN) mice. Pyroptosis is involved in high glucose (HG)-induced tubular cells injury, characterized by activation of Gasdermin D (GSDMD) and the release of IL-1β and IL-18, resulting in inflammatory injury in DN. It is reasonable to assume that ALPK1 is involved in pyroptosis-related tubular injury in DN. However, the mechanism remains poorly defined. Methods Immunohistochemistry (IHC) staining was performed to detect the expression of pyroptosis- and fibrosis-related proteins in renal sections of DN patients and DN mice. DN models were induced through injection of streptozotocin combined with a high-fat diet. Protein levels of ALPK1, NF-κB, Caspase-1, GSDMD, IL-1β, IL-18 and α-SMA were detected by Western blot. HK-2 cells treated with high-glucose (HG) served as an in vitro model. ALPK1 small interfering RNA (siRNA) was transfected into HK-2 cells to down-regulate ALPK1. The pyroptosis rates were determined by flow cytometry. The concentrations of IL-1β and IL-18 were evaluated by ELISA kits. Immunofluorescence staining was used to observe translocation of NF-κB and GSDMD. Results The heat map of differentially expressed genes showed that ALPK1, Caspase-1 and GSDMD were upregulated in the DN group. The expression levels of ALPK1, Caspase-1, GSDMD and CD68 were increased in renal biopsy tissues of DN patients by IHC. ALPK1expression and CD68+ macrophages were positively correlated with tubular injury in DN patients. Western blot analysis showed increased expressions of ALPK1, phospho-NF-κB P65, GSDMD-NT, and IL-1β in renal tissues of DN mice and HK-2 cells, accompanied with increased renal fibrosis-related proteins (FN, α-SMA) and macrophages infiltration in interstitial areas. Inhibition of ALPK1 attenuated HG-induced upregulation expressions of NF-κB, pyroptosis-related proteins Caspase-1, GSDMD-NT, IL-1β, IL-18, α-SMA, and pyroptosis level in HK-2 cells. Also, the intensity and nuclear translocation of NF-κB and membranous translocation of GSDMD were ameliorated in HG-treated HK-2 cells after treatment with ALPK1 siRNA. Conclusions Our data suggest that ALPK1/NF-κB pathway initiated canonical caspase-1-GSDMD pyroptosis pathway, resulting in tubular injury and interstitial inflammation of DN.

Abstract The water-soluble polysaccharide (BHCP) was isolated from the hot aqueous extract of Chieh qua (Benincasa hispida var. chieh-qua How) fruit. The polysaccharide was found to contain D-galactose and D-glucose in a molar ratio of 2.59:1 with both α- and β-glycosidic bond. The strong free radicals scavenging activity on DPPH, ABTS, and hydroxyl radicals of the BHCP was demonstrated, and showing the BHCP from Chieh qua has potential application value on the functional food.

Resumo Este artigo procura reconhecer as possibilidades radicais nos modos pelos quais a existência humana é percebida e construída na era digital. Uma etnografia de 15 meses, focalizando o uso das redes sociais entre os operários chineses, é empregada para abrir uma conversa com pensamentos filosóficos sobre a existência humana e pensamentos antropológicos sobre objetificação. Afinal, as mídias sociais são mais do que uma forma de comunicação ou uma tecnologia que facilita a conexão entre diferentes locais. Ao explorar as três camadas de experiência existencial dos migrantes rurais chineses no contexto do uso onipresente da mídia social, o artigo sugere que podemos começar a considerar o grau em que a mídia digital é em si um lugar em que as pessoas realmente vivem e se sentem em casa. O reconhecimento de tal construção de lugar por meio do digital nos permite repensar a relação entre a materialidade e as possibilidades digitais para a existência humana e explorar mais o processo fundamental de objetivação pelas lentes da antropologia digital.

Abstract This paper sets out to acknowledge the radical possibilities in the way in which human existence is perceived and constructed in the digital age. A 15-month ethnography, focused on the use of social media among Chinese factory workers, is employed to create a conversation with philosophical thoughts on human existence and anthropological thoughts on objectification. Social media is more than a form of communication, or a technology, that facilitates the connection between different locations. By exploring the three layers of existential experience of Chinese rural migrants in the context of ubiquitous social media use, this paper suggests that we might start to consider the degree to which digital media is itself a place in which people actually live and feel at home. The acknowledgement of such place-making via the digital allows us to re-think the relationship between the materiality and digital possibilities for human existence and further explore the fundamental process of objectification through the lens of digital anthropology.