ABSTRACT Objective: To evaluate objective treatment efficacy and safety, and subjective patient-reported outcomes in patients with complex ureteral strictures (US) undergoing minimally invasive lingual mucosal graft ureteroplasty (LMGU). Materials and Methods: We prospectively enrolled patients underwent robotic or laparoscopic LMGU between May 2020 and July 2022. Clinical success was defined as symptom-free and no radiographic evidence of re-obstruction. Patient-reported outcomes, including health-related quality of life (HRQoL), mental health status and oral health-related quality of life (OHRQoL), were longitudinally evaluated before surgery, 6 and 12 months postoperatively. Results: Overall, 41 consecutive patients were included. All procedures were performed successfully with 32 patients in robotic approach and 9 in laparoscopic. Forty (97.56%) patients achieved clinical success during the median follow-up of 29 (range 15-41) months. Although patients with complex US experienced poor baseline HRQoL, there was a remarkable improvement following LMGU. Specifically, the 6-month and 12-month postoperative scores were significantly improved compared to the baseline (p < 0.05) in most domains. Twenty-eight (68.3%) and 31 (75.6%) patients had anxiety and depression symptoms before surgery, respectively. However, no significant decrease in the incidence of these symptoms was observed postoperatively. Moreover, there was no significant deterioration of OHRQoL at 6 months and 12 months postoperatively when compared to the baseline. Conclusions: LMGU is a safe and efficient procedure for complex ureteral reconstruction that significantly improves patient-reported HRQoL without compromising OHRQoL. Assessing patients’ quality of life enables us to monitor postoperative recovery and progress, which should be considered as one of the criteria for surgical success. Objective safety patientreported patient reported (US . (LMGU) Methods 202 2022 symptomfree symptom free reobstruction. reobstruction re obstruction. obstruction re-obstruction Patientreported Patient healthrelated related , (HRQoL) OHRQoL, (OHRQoL) surgery 1 Results Overall 4 included 3 97.56% 9756 97 56 (97.56% followup follow up 2 range 1541 15 15-41 Specifically 6month month 12month p 0.05 005 0 05 domains Twentyeight Twenty eight 68.3% 683 68 (68.3% 75.6% 756 75 (75.6% respectively However Moreover Conclusions progress (LMGU 20 (HRQoL (OHRQoL 97.56 975 5 (97.56 154 15-4 0.0 00 68.3 (68.3 75.6 7 (75.6 97.5 (97.5 15- 0. 68. (68. 75. (75. 97. (97. (68 (75 (97 (6 (7 (9 (

Abstract To solve the problem that the mechanical behavior of undisturbed loess in seasonally frozen soil area is affected by freeze-thaw action, triaxial shear tests of undisturbed loess under freeze-thaw condition were carried out. The results show that the mechanical properties of undisturbed loess are greatly affected by factors including freeze-thaw process, water content, natural density and confining pressure. Freeze-thaw action has a certain impact on the failure surface shape and stress-strain curve. Before and after freeze-thaw, the shape of the shear failure surface is complex, including single oblique failure surface, double oblique failure surface, vertical failure surface, X-shaped failure surface, bulging failure, etc. And under the conditions of low water content, low confining pressure and high dry density, the stress-strain curve tends to be softened. Conversely, the curve tends to harden. Freeze-thaw action can make the stress-strain curve transition from softening to hardening. In addition, the freeze-thaw action significantly weakens the failure strength, shear strength, cohesion, initial tangent modulus and failure ratio of undisturbed soil, but does not change the internal friction angle obviously. Also, the heterogeneity of natural soil is also an important factor affecting the mechanical parameters, failure surface shape and stress-strain curve of undisturbed loess. freezethaw freeze thaw out process content Freezethaw Freeze stressstrain stress strain freezethaw, thaw, complex Xshaped X shaped etc softened Conversely harden hardening addition strength cohesion obviously Also parameters

ABSTRACT This systematic review and meta-analysis assessed the association between urinary tract infections (UTIs) during pregnancy and the risk of preterm birth (PTB). We searched multiple databases for relevant observational studies, categorizing them as UTI-based (comparing PTB incidence in women with and without UTIs) or PTB-based (comparing UTI prevalence in women with and without PTB). Using a random-effects model in Stata software version 17.0, we estimated pooled and adjusted odds ratios (ORs) with 95% confidence intervals (CIs), and performed subgroup, sensitivity, and cumulative analyses to explore heterogeneity. In total, 30 studies comprising 32 datasets were included, involving a total of 249,810 cases and 2,626,985 healthy controls. The meta-analysis revealed a significant positive association between UTIs during pregnancy and PTB occurrence (OR, 1.92; 95% CI, 1.62–2.27). A sub-group analysis based on studies, the participants showed significant association in both PTB-based (OR, 2.01; 95% CI, 1.58–2.56) and UTI-based studies (OR, 1.79; 95% CI, 1.42–2.26). However, Egger’s test indicated the presence of publication bias (p=0.020), and substantial heterogeneity was observed across the included studies (I2=96.6; p< 0.001). These findings emphasize the critical importance of early detection and effective management of UTIs in pregnant women to reduce the risk of PTB and its associated adverse outcomes. While the results highlight a robust link between UTIs during pregnancy and PTB risk, the potential influence of publication bias and substantial heterogeneity should be considered to interpret these findings. Further research is needed to better understand the underlying mechanisms and to develop targeted interventions for high-risk pregnant women. metaanalysis meta (UTIs PTB. . (PTB) UTIbased comparing PTBbased PTB) randomeffects random effects 170 17 0 17.0 ORs (ORs 95 CIs, CIs , (CIs) subgroup sensitivity 3 249810 249 810 249,81 2626985 2 626 985 2,626,98 controls OR, OR (OR 1.92 192 1 92 CI 1.62–2.27. 162227 1.62–2.27 62 27 1.62–2.27) sub group 2.01 201 01 1.58–2.56 158256 58 56 1.79 179 79 1.42–2.26. 142226 1.42–2.26 42 26 1.42–2.26) However Eggers Egger s p=0.020, p0020 p p=0.020 020 (p=0.020) I2=96.6 I2966 I I2 96 6 (I2=96.6 0.001. 0001 0.001 001 0.001) outcomes highrisk high (PTB 17. 9 (CIs 24981 24 81 249,8 262698 98 2,626,9 1.9 19 16222 1.62–2.2 2.0 20 1.58–2.5 15825 5 1.7 7 14222 1.42–2.2 4 p002 p=0.02 02 (p=0.020 I2=96. I296 (I2=96. 000 0.00 00 2498 8 249, 26269 2,626, 1. 1622 1.62–2. 2. 1.58–2. 1582 1422 1.42–2. p00 p=0.0 (p=0.02 I2=96 I29 (I2=96 0.0 2626 2,626 162 1.62–2 1.58–2 158 142 1.42–2 p0 p=0. (p=0.0 I2=9 (I2=9 0. 262 2,62 16 1.62– 1.58– 15 14 1.42– p=0 (p=0. I2= (I2= 2,6 1.62 1.58 1.42 p= (p=0 (I2 2, 1.6 1.5 1.4 (p= (I (p

Objetivo: examinar a relação entre o sucesso profissional e o ambiente de trabalho de enfermeiros da área de tecnologia de reprodução assistida e identificar os fatores que afetaram tal sucesso. Método: estudo transversal conduzido em 53 centros de fertilidade em 26 províncias da China Continental. Os dados foram coletados por meio de um questionário demográfico, um questionário sobre competências de enfermagem especializada em tecnologias de reprodução assistida, da Career-Success Scale (Escala de Sucesso Profissional) e da Nursing Work Environment Scale (Escala do Ambiente de Trabalho na Enfermagem). Aplicaram-se análises de estatística descritiva e inferencial. Resultados: participaram do estudo 597 enfermeiros da área de tecnologia de reprodução assistida, e 555 questionários válidos foram coletados. As pontuações globais médias para o sucesso profissional e o ambiente de trabalho foram 3,75 [desvio padrão (DP) = 1,01] e 3,42 (DP = 0,77), respectivamente. Verificou-se forte correlação positiva entre o sucesso profissional e o ambiente de trabalho (r = 0,742; p < 0,01). A análise de regressão múltipla mostrou que a participação em eventos acadêmicos, a assistência psicológica, o desenvolvimento profissional, o apoio e os cuidados, e o salário e o bem-estar foram fatores que influenciaram significativamente o sucesso profissional. Conclusão: a participação em eventos acadêmicos, a assistência psicológica e o ambiente de trabalho mostraram correlação positiva com o sucesso profissional. Os gestores deveriam considerar formas de abordar esses fatores. Objetivo Método 5 2 Continental demográfico CareerSuccess Career Success Escala Profissional Enfermagem. Enfermagem . Enfermagem) Aplicaramse Aplicaram se inferencial Resultados 59 55 375 3 75 3,7 desvio DP 1,01 101 1 01 342 42 3,4 0,77, 077 0,77 , 0 77 0,77) respectivamente Verificouse Verificou r 0,742 0742 742 0,01. 001 0,01 0,01) acadêmicos cuidados bemestar bem estar Conclusão 37 7 3, 1,0 10 34 4 07 0,7 0,74 074 74 00 0,0 1, 0,

Objective: to examine the relationship between career success and work environment of nurses who practice in assisted reproductive technology and to identify factors that affect career success. Method: a cross-sectional study conducted in 53 fertility centres in 26 provinces in mainland China. Data were collected using a demographic data questionnaire, a specialised nursing competence questionnaire, the Career-Success Scale, and the Nursing Work Environment Scale. Descriptive and inferential statistics were applied. Results: 597 assisted reproductive technology nurses participated in our survey, and 555 valid questionnaires were collected. Theoverall mean scores for career success and work environment were 3.75 [standard deviation (SD) = 1.01] and 3.42 (SD = 0.77) respectively. There was a strong positive correlation between career success and work environment (r = 0.742, p < 0.01). Multiple regression showed that attending academic conferences, psychological care, professional development, support and care, salary, and welfare were significant factors that influence career success. Conclusion: attending academic conferences, psychological care, and work environment are positively related to career success. Administrators should consider ways to address these factors. Objective Method crosssectional cross sectional 5 2 China questionnaire CareerSuccess Career Success Scale applied Results 59 survey 55 375 3 75 3.7 standard SD 1.01 101 1 01 342 42 3.4 0.77 077 0 77 respectively r 0742 742 0.742 0.01. 001 0.01 . 0.01) conferences care development salary Conclusion 37 7 3. 1.0 10 34 4 0.7 07 074 74 0.74 00 0.0 1. 0.

Objetivo: examinar la relación entre éxito en la carrera y ambiente de trabajo con enfermeras actuantes en tecnología de reproducción asistida (TRA), e identificar factores que afectan su éxito en la carrera. Método: estudio transversal realizado en 53 centros de fertilidad de 26 provincias en la China Continental. Datos recolectados utilizando cuestionario de datos demográficos, un Cuestionario de Competencias de TRA para Enfermeras Especializadas, la Career-Success Scale (Escala de éxito profesional) y la Nursing Work Environment Scale (Escala del entorno de trabajo de enfermería). Se aplicó estadística inferencial y descriptiva. Resultados: 597 enfermeras actuantes en TRA participaron en nuestra encuesta, entregando 555 cuestionarios válidos. Los puntajes generales promedio de éxito en la carrera y ambiente de trabajo fueron 3,75 (desviación estándar, [DE]=1,01) y 3,42 (DE=0,77) respectivamente. Se observó fuerte correlación positiva entre éxito en la carrera y ambiente de trabajo (r=0,742; p<0,01). La regresión múltiple mostró que la concurrencia a conferencias académicas, atención psicológica, desarrollo profesional, apoyo y cuidado, salario y bienestar constituyeron factores significantes con influencia en el éxito en la carrera. Conclusión: la concurrencia a conferencias académicas, atención psicológica y ambiente de trabajo guardan relación positiva con el éxito en la carrera. Los gestores deberían considerar formas de abordar tales factores. Objetivo TRA, , (TRA) Método 5 2 Continental demográficos Especializadas CareerSuccess Career Success Escala profesional enfermería. enfermería . enfermería) descriptiva Resultados 59 encuesta 55 válidos 375 3 75 3,7 desviación estándar DE=1,01 DE101 DE =1,01 1 01 [DE]=1,01 342 42 3,4 DE=0,77 DE077 0 77 (DE=0,77 respectivamente r=0,742 r0742 r 742 (r=0,742 p<0,01. p001 p p<0,01 p<0,01) académicas cuidado Conclusión (TRA 37 7 3, DE=1,0 DE10 101 =1,0 [DE]=1,0 34 4 DE=0,7 DE07 (DE=0,7 r=0,74 r074 74 (r=0,74 p00 p<0,0 DE=1, DE1 10 =1, [DE]=1, DE=0, DE0 (DE=0, r=0,7 r07 (r=0,7 p0 p<0, DE=1 =1 [DE]=1 DE=0 (DE=0 r=0, r0 (r=0, p<0 DE= = [DE]= (DE= r=0 (r=0 p< [DE] (DE r= (r= [DE (r

ABSTRACT The original two-order separating sieve has a good potato-soil separating ability, but it causes significant damage to potatoes while ensuring a high potato detection rate, which in turn affects the working effectiveness of the potato digger. Thus, it is necessary to improve the design of the original swing separation sieve with a two-order sieve surface to one with a three-order sieve surface to solve the contradiction between the potato detection and potato damage. On this basis, the movement characteristics of potatoes and the separation performance of the new sieve were experimentally investigated. The experiment was conducted in a test field in Wuchuan County using a completely randomized design in a single-factor scheme with three factors and five levels, with five crank speeds (140, 150, 180, 210 and 225 rpm), five machine forward speeds (1.41, 1.51, 1.70, 1.89 and 2.21 km h-1) and five boom-connecting rod length combinations (250-350-1,030, 250-370-1,040, 270-370-1,050, 290-370-1,060 and 310-370-1,070 mm). Each experiment was repeated three times at each level, and the average value was taken as the final result. The experimental results demonstrate that the new three-order separation sieve can ensure a high potato detection rate while maintaining a low potato skin breakage rate. twoorder two order potatosoil soil ability digger Thus threeorder basis investigated singlefactor single factor levels 140, 140 (140 150 180 21 22 rpm, rpm , rpm) 1.41, 141 1 41 (1.41 151 51 1.51 170 70 1.70 189 89 1.8 221 2 2.2 h1 h h-1 boomconnecting boom connecting 2503501,030, 2503501030 250 350 1,030, 030 (250-350-1,030 2503701,040, 2503701040 370 1,040, 040 250-370-1,040 2703701,050, 2703701050 270 1,050, 050 270-370-1,050 2903701,060 2903701060 290 1,060 060 290-370-1,06 3103701,070 3103701070 310 1,070 070 310-370-1,07 mm. mm . mm) level result 14 (14 15 18 1.41 4 (1.4 5 1.5 17 7 1.7 8 1. 2. h- 2503501 2503501,030 250350103 25 35 1030 1,030 03 (250-350-1,03 2503701 2503701,040 250370104 37 1040 1,040 04 250-370-1,04 2703701 2703701,050 270370105 27 1050 1,050 05 270-370-1,05 2903701 2903701,06 290370106 29 1060 1,06 06 290-370-1,0 3103701 3103701,07 310370107 31 1070 1,07 07 310-370-1,0 (1 1.4 (1. 250350 2503501,03 25035010 3 103 1,03 0 (250-350-1,0 250370 2503701,04 25037010 104 1,04 250-370-1,0 270370 2703701,05 27037010 105 1,05 270-370-1,0 290370 2903701,0 29037010 106 1,0 290-370-1, 310370 3103701,0 31037010 107 310-370-1, ( 25035 2503501,0 10 (250-350-1, 25037 2503701,0 250-370-1, 27037 2703701,0 270-370-1, 29037 2903701, 1, 290-370-1 31037 3103701, 310-370-1 2503 2503501, (250-350-1 2503701, 250-370-1 2703 2703701, 270-370-1 2903 290-370- 3103 310-370- (250-350- 250-370- 270-370- 290-370 310-370 (250-350 250-370 270-370 290-37 310-37 (250-35 250-37 270-37 290-3 310-3 (250-3 250-3 270-3 290- 310- (250- 250- 270- (250 (25 (2

RESUMO A peneira de separação de duas ordens original tem uma boa capacidade de separação batata-solo, mas causa danos significativos às batatas ao mesmo tempo em que garante uma alta taxa de evidência de batatas, o que, por sua vez, afeta a eficácia do trabalho da escavadeira de batatas. Assim, o estudo teve como objetivo aprimorar a peneira de separação de balanço original com uma superfície de peneira de duas ordens para uma nova peneira de separação com uma superfície de peneira de três ordens para resolver a contradição entre a taxa obvia de batatas e os danos às batatas na operação da peneira original. Com base nisso, as características de movimentação das batatas e o desempenho de separação da nova peneira foram investigados experimentalmente no campo. O experimento foi conduzido em um campo de teste no Condado de Wuchuan, utilizando um delineamento completamente aleatório em um esquema de fator único com três fatores e cinco níveis, com cinco velocidades de manivela (140, 150, 180, 210 e 225 rpm), cinco velocidades de avanço da máquina (1,41, 1,51, 1,70, 1,89 e 2,21 km h-1) e cinco combinações de comprimento da haste de ligação do braço (250-350-1.030, 250-370-1.040, 270-370-1.050, 290-370-1.060 e 310-370-1.070 mm). Cada experimento foi repetido três vezes em cada nível, e o valor médio foi considerado como o resultado final. Os resultados experimentais demonstram que a nova peneira de separação de três ordens pode garantir uma alta taxa de detecção de batatas enquanto mantém uma baixa taxa de danos à casca das batatas. batatasolo, batatasolo batata solo, solo batata-solo vez Assim nisso Wuchuan níveis 140, 140 (140 150 180 21 22 rpm, rpm , rpm) 1,41, 141 1 41 (1,41 151 51 1,51 170 70 1,70 189 89 1,8 221 2 2,2 h1 h h-1 2503501.030, 2503501030 250 350 1.030, 030 (250-350-1.030 2503701.040, 2503701040 370 1.040, 040 250-370-1.040 2703701.050, 2703701050 270 1.050, 050 270-370-1.050 2903701.060 2903701060 290 1.060 060 290-370-1.06 3103701.070 3103701070 310 1.070 070 310-370-1.07 mm. mm . mm) nível final 14 (14 15 18 1,41 4 (1,4 5 1,5 17 7 1,7 8 1, 2, h- 2503501 2503501.030 250350103 25 35 1030 1.030 03 (250-350-1.03 2503701 2503701.040 250370104 37 1040 1.040 04 250-370-1.04 2703701 2703701.050 270370105 27 1050 1.050 05 270-370-1.05 2903701 2903701.06 290370106 29 1060 1.06 06 290-370-1.0 3103701 3103701.07 310370107 31 1070 1.07 07 310-370-1.0 (1 1,4 (1, 250350 2503501.03 25035010 3 103 1.03 0 (250-350-1.0 250370 2503701.04 25037010 104 1.04 250-370-1.0 270370 2703701.05 27037010 105 1.05 270-370-1.0 290370 2903701.0 29037010 106 1.0 290-370-1. 310370 3103701.0 31037010 107 310-370-1. ( 25035 2503501.0 10 (250-350-1. 25037 2503701.0 250-370-1. 27037 2703701.0 270-370-1. 29037 2903701. 1. 290-370-1 31037 3103701. 310-370-1 2503 2503501. (250-350-1 2503701. 250-370-1 2703 2703701. 270-370-1 2903 290-370- 3103 310-370- (250-350- 250-370- 270-370- 290-370 310-370 (250-350 250-370 270-370 290-37 310-37 (250-35 250-37 270-37 290-3 310-3 (250-3 250-3 270-3 290- 310- (250- 250- 270- (250 (25 (2

Abstract Introduction: nutritional status and platelet-to-lymphocyte ratio (PLR) have been found to be associated with prognosis in patients with hepatocellular carcinoma (HCC) undergoing transcatheter arterial chemoembolization (TACE). Objectives: to evaluate the association between nutritional status and PLR in patients with HCC undergoing TACE. Methods: a total of 152 HCC patients received TACE were enrolled. The nutritional status was evaluated by Patient-Generated Subjective Global Assessment (PG-SGA). Patients with PG-SGA A and PG-SGA (B or C) were classified as the well-nourished and malnourished groups. Results: according to the PG-SGA, 130 (85.5 %) patients were malnourished. The median PLR was significantly different between well-nourished and malnourished groups (p = 0.008). A positive correlation was found between PLR and PG-SGA score (r = -0.265, p = 0.001). The optimal PLR cutoff value was 102.165 to predict malnutrition, with a sensitivity of 65.4 %, specificity of 72.7 %, and an area under the curve (AUC) of 0.677 (95 % confidence interval (CI): 0.550-0.804; p = 0.008). A logistic stepwise regression model showed that the PLR was associated with nutritional status in Model 1 without adjustment, as well as if adjusted by age, sex, type of TACE (c-TACE/DEB-TACE) and Child–Pugh stage (odds ratio, 0.190; 95 % CI: 0.062-0.582; p = 0.004). Conclusions: nutritional status measured by PG-SGA was significantly associated with PLR in patients with HCC undergoing TACE.

Resumen Introducción: se ha encontrado que el estado nutricional y el índice plaquetas-linfocitos (PLR) se asocian con el pronóstico en pacientes con carcinoma hepatocelular (CHC) sometidos a quimioembolización transarterial (TACE). Objetivos: evaluar la asociación entre el estado nutricional y la PLR en pacientes con CHC sometidos a TACE. Métodos: se evaluaron 152 pacientes con CHC que recibieron TACE. El estado nutricional fue evaluado por Evaluación Global Subjetiva Generada por el Paciente (PG-SGA). Los pacientes con PG-SGA A y PG-SGA (B o C) se clasificaron como los grupos bien nutridos y desnutridos. Resultados: según la PG-SGA, 130 (85,5 %) pacientes estaban desnutridos. La mediana de PLR fue significativamente diferente entre los grupos bien nutridos y desnutridos (p = 0,008). Se encontró una correlación positiva entre PLR y la puntuación PG-SGA (r = -0,265, p = 0,001). El valor de corte óptimo de PLR fue de 102,165 para predecir la malnutrición, con una sensibilidad del 65,4 %, una especificidad del 72,7 % y un área bajo la curva (AUC) de 0,677 (intervalo de confianza [IC] del 95 %: 0,550-0,804; p = 0,008). Un modelo de regresión logística escalonada mostró que el PLR se asoció con el estado nutricional en el Modelo 1 sin ajuste, así como cuando se ajustó por edad, sexo, tipo de TACE (c-TACE/DEB-TACE) y etapa Child-Pugh (odds ratio, 0,190; IC 95 %: 0,062-0,582; p = 0,004). Conclusiones: el estado nutricional medido por PG-SGA se asoció significativamente con PLR en pacientes con CHC sometidos a TACE.

The low-temperature electrochemical corrosion behavior of aircraft 2024 aluminum alloy was investigated in different concentrations of potassium-acetate-type fluid, and the results showed that the corrosion medium initially impacted some corrosiveness on the 2024 aluminum alloy. However, the corrosion rate of the alloy decreased with prolonged immersion in the corrosion medium, and this was attributed to the protective effect of the corrosion products layer, which impeded the attack by the aggressive solution. Time-domain analysis of electrochemical noise measurements at -5 °C revealed the occurrence of uniform corrosion on the alloy at the initial stages of immersion, general corrosion at the middle stages of immersion, and a pitting-dominated corrosion type from the middle to late stages of immersion. lowtemperature low temperature 202 potassiumacetatetype potassium acetate fluid However layer solution Timedomain Time domain 5 - C pittingdominated pitting dominated 20 2

In this paper, the multi-layer multi-pass welding process was used to weld 115mm 08Cr9W3Co3VNbCuBN (G115) steel pipe, the gas tungsten arc welding (GTAW) was used in root pass welding, subsequent welding by dynamic hot wire gas tungsten arc welding (TIP TIG) welding method, while the post-weld heat treatment (PWHT) of 770°C × 10h was carried out afterward. The microstructure and mechanical properties of different zones of the welded joint were analyzed by OM, SEM, XRD, microhardness and impact tests. The results showed that the ferrite and martensite were observed in the weld metal (WM), the fine-grained heat-affected zone (FGHAZ) and the coarse-grained heat-affected zone (CGHAZ) consisting of prior austenitic grain boundaries (PAGBs) and martensite, and more precipitates including coarse M23C6 carbides with fine MX-type carbonitrides were observed inside the grain boundaries and grains. The hardness distribution patterns along different locations (Cover, Fill, Root) on the welded joint cross-section were the same, from base metal (BM) to WM hardness gradually increased, and WM hardness was the highest. WM impact toughness was worse than HAZ, impact fracture mode was a mixed tough-brittle fracture but biased towards brittle fracture. paper multilayer multi layer multipass mm CrWCoVNbCuBN Cr W Co VNbCuBN G115 G (G115 pipe GTAW (GTAW TIP TIG method postweld post PWHT (PWHT 770C C 770 h afterward OM SEM XRD tests WM, , (WM) finegrained grained heataffected affected FGHAZ (FGHAZ coarsegrained CGHAZ (CGHAZ PAGBs (PAGBs MC M M23C MXtype MX type grains Cover, Cover (Cover Fill Root crosssection cross section same BM (BM increased highest HAZ toughbrittle tough G11 (G11 77 (WM G1 (G1 7 (G

ABSTRACT Purpose: To explore the protection of naringenin against oxygen-glucose deprivation/reperfusion (OGD/R)-induced HT22 cell injury, a cell model of cerebral ischemia/reperfusion (I/R) injury in vitro, focusing on SIRT1/FOXO1 signaling pathway. Methods: Cytotoxicity, apoptosis, reactive oxygen species (ROS) generation, malondialdehyde (MDA) content, 4-hydroxynonenoic acid (4-HNE) level, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities were measured by commercial kits. Inflammatory cytokines levels were determined by enzyme-linked immunosorbent assay (ELISA). The protein expressions were monitored by Western blot analysis. Results: Naringenin significantly ameliorated OGD/R-induced cytotoxicity and apoptosis in HT22 cells. Meanwhile, naringenin promoted SIRT1 and FOXO1 protein expressions in OGD/R-subjected HT22 cells. In addition, naringenin attenuated OGD/R-induced cytotoxicity, apoptosis, oxidative stress (the increased ROS, MDA and 4-HNE levels, and the decreased SOD, GSH-Px and CAT activities) and inflammatory response (the increased tumor necrosis factor-α, interleukin [IL]-1β, and IL-6 levels and the decreased IL-10 level), which were blocked by the inhibition of the SIRT1/FOXO1 signaling pathway induced by SIRT1-siRNA transfection. Conclusions: Naringenin protected HT22 cells against OGD/R injury depending on its antioxidant and anti-inflammatory activities via promoting the SIRT1/FOXO1 signaling pathway. Purpose oxygenglucose glucose deprivationreperfusion deprivation reperfusion OGD/Rinduced OGDRinduced OGD R HT HT2 ischemiareperfusion ischemia I/R IR I (I/R vitro SIRT1FOXO1 SIRTFOXO SIRT FOXO SIRT1/FOXO Methods Cytotoxicity ROS (ROS generation (MDA content 4hydroxynonenoic hydroxynonenoic 4 4HNE HNE (4-HNE level SOD , (SOD) GSHPx GSH Px (GSH-Px (CAT kits enzymelinked enzyme linked ELISA. ELISA . (ELISA) analysis Results Meanwhile OGD/Rsubjected OGDRsubjected subjected addition factorα, factorα factor α, α factor-α IL1β, IL1β ILβ IL 1β, 1β β [IL]-1β IL6 6 IL- IL10 10 IL-1 level) SIRT1siRNA SIRTsiRNA siRNA transfection Conclusions OGDR antiinflammatory anti Rinduced SIRT1FOXO (SOD (ELISA Rsubjected IL1 1

Abstract Background Stroke is a major global public health problem, affecting 13.7 million people worldwide. Previous studies have found a neuroprotective effect of hypothermia therapy and the efficacy and safety of combined hypothermia and mechanical thrombectomy or thrombolysis in the treatment of ischemic stroke have also attracted attention. Objective In the present research, the authors conducted a meta-analysis to comprehensively assess the safety and efficacy of hypothermia combining mechanical thrombectomy or thrombolysis in the treatment of ischemic stroke. Methods Articles published from January 2001 to May 2022 were searched from Google Scholar, Baidu Scholar and PubMed to evaluate the clinical significance of hypothermia treatment in ischemic stroke. Complications, short-term mortality, and the modified Rankin Scale (mRS) in the full text was extracted. Results 89 publications were selected and 9 among them were included in this study with sample size of 643. All selected studies are in accordance with the inclusion criteria. Forest plot of clinical characteristics was as follows: complications (RR = 1.132, 95% CI 0.942‒1.361, p = 0.186, I2= 37.2%), mortality within 3 months (RR = 1.076, 95% CI 0.694‒1.669, p = 0.744, I2= 0.00%), mRS ≤ 1 at 3 months (RR = 1.138, 95% CI 0.829‒1.563, p = 0.423, I2= 26.0%), mRS ≤ 2 at 3 months (RR = 1.672, 95% CI 1.236‒2.263, p = 0.001, I2=49.6%) and mRS ≤ 3 at 3 months (RR = 1.518, 95% CI 1.128‒2.043, p = 0.006, I2= 0.00%). The funnel plot suggested that there was no significant publication bias in the meta-analysis on complications, mortality within 3 months, mRS ≤ 1 at 3 months and mRS ≤ 2 at 3 months. Conclusion In summary, the results showed that hypothermia treatment was correlated with mRS ≤ 2 at 3 months, but not linked with complications and mortality within 3 months. problem 137 13 7 13. worldwide attention research metaanalysis meta analysis 200 202 Complications shortterm short term (mRS extracted 8 643 criteria follows RR 1132 132 1.132 95 09421361 0 942 361 0.942‒1.361 0186 186 0.186 I2 I 37.2%, 372 37.2% , 37 37.2%) 1076 076 1.076 06941669 694 669 0.694‒1.669 0744 744 0.744 0.00%, 000 0.00% 00 0.00%) 1138 138 1.138 08291563 829 563 0.829‒1.563 0423 423 0.423 26.0%, 260 26.0% 26 26.0%) 1672 672 1.672 12362263 236 263 1.236‒2.263 0001 001 0.001 I2=49.6% I2496 49 6 1518 518 1.518 11282043 128 043 1.128‒2.043 0006 006 0.006 0.00%. . summary 20 64 113 1.13 0942136 94 36 0.942‒1.36 018 18 0.18 37.2 107 07 1.07 0694166 69 66 0.694‒1.66 074 74 0.74 0.00 0829156 82 56 0.829‒1.56 042 42 0.42 26.0 167 67 1.67 1236226 23 1.236‒2.26 I2=49.6 I249 4 151 51 1.51 1128204 12 04 1.128‒2.04 11 1.1 094213 0.942‒1.3 01 0.1 37. 10 1.0 069416 0.694‒1.6 0.7 0.0 082915 5 0.829‒1.5 0.4 26. 16 1.6 123622 1.236‒2.2 I2=49. I24 15 1.5 112820 1.128‒2.0 1. 09421 0.942‒1. 0. 06941 0.694‒1. 08291 0.829‒1. 12362 1.236‒2. I2=49 11282 1.128‒2. 0942 0.942‒1 0694 0.694‒1 0829 0.829‒1 1236 1.236‒2 I2=4 1128 1.128‒2 094 0.942‒ 069 0.694‒ 082 0.829‒ 123 1.236‒ 112 1.128‒ 09 0.942 06 0.694 08 0.829 1.236 1.128 0.94 0.69 0.82 1.23 1.12 0.9 0.6 0.8 1.2

Abstract Objectives The pathological mechanisms of patients with Renal Cell Carcinoma (RCC) remain defined. This study aimed to evaluate relationships between the landscape of gene mutations and their clinical significance in RCC patients. Methods Tissue and peripheral blood samples of 42 patients with RCC were collected and performed for the Next Generation Sequencing (NGS) with Geneseeq PrimeTM 425-gene panel probes. Their landscapes of gene mutation were analyzed. We also carried out an evaluation of Tumor-Node-Metastasis (TNM) staging, RENAL nephelometry score, surgery, and targeted drug treatment of patients. Then we compared the correlations of landscape in gene mutations and the prognosis. Results The most common gene alternations, including BAP1, PBRM1, SETD2, CSF1R, NPM1, EGFR, POLE, RB1, and VHL genes, were identified in tissue and blood samples of 75% of patients. EGFR, POLE, and RB1 gene mutations frequently occurred in relapsed and metastatic patients. BAP1, CCND2, KRAS, PTPN11, ERBB2/3, JAK2, and POLE were presented in the patients with > 9 RENAL nephelometry score. Univariable analysis indicated that SETD2, BAP1, and PBRM1 genes were key factors for Disease-Free Survival (DFS). Multivariable analysis confirmed that mutated SETD1, NPM1, and CSF1R were critical factors for the Progression Free Survival (PFS) of RCC patients with target therapy. Conclusions Wild-type PBRM1 and mutated BAP1 in patients with RCC were strongly associated with the outcomes of the patient. The PFS of the patients with SETD2, NPM1, and CSF1R mutations were significantly shorter than those patients without variants. (RCC defined 4 NGS (NGS 425gene 425 probes analyzed TumorNodeMetastasis Tumor Node Metastasis TNM (TNM staging score surgery prognosis alternations BAP PBRM SETD2 SETD CSFR CSF R NPM1 NPM EGFR RB 75 CCND2 CCND KRAS PTPN11 PTPN ERBB23 ERBB ERBB2 3 ERBB2/3 JAK2 JAK DiseaseFree Disease DFS. DFS . (DFS) SETD1 (PFS therapy Wildtype Wild type patient variants 7 PTPN1 ERBB2/ (DFS

Abstract High entropy alloy is a multi-component alloy material with equal or near atomic number, which has excellent wear resistance and corrosion resistance. In this paper, AlxFeCoCrNiMn (x = 0,0.5,1.0,1.5) high entropy alloy cladding layer was prepared by laser cladding on Q345 steel plate. The phase structure, microstructure, hardness and wear resistance of the cladding layer were studied. The results show that the cladding layer of AlxFeCoCrNiMn alloy has good metallurgical bonding ability with Q345 steel. The cladding area is mainly columnar and equiaxed. The cladding layer of AlxFeCoCrNiMn alloy is mainly composed of BCC + FCC solid solution phase, which is caused by the addition of Al element under the high entropy effect. Al element promotes the formation of BCC phase structure. With the increase of Al element, the hardness of cladding layer increases. The hardness of A1.0 cladding layer is 670HV, which is close to three times of Q345 steel. When Al (x = 1.0), the hardness of the cladding layer is the highest, and it also shows better wear resistance with lower friction and wear loss. multicomponent multi component number paper x 0,0.5,1.0,1.5 0051015 0 5 1 Q Q34 plate structure microstructure studied equiaxed effect increases A10 A A1 A1. 670HV HV 1.0, 10 1.0 , 1.0) highest loss 0,0.5,1.0,1. 005101 Q3 1. 0,0.5,1.0,1 00510 0,0.5,1.0, 0051 0,0.5,1.0 005 0,0.5,1. 00 0,0.5,1 0,0.5, 0,0.5 0,0. 0,0 0,

Abstract Background The main features of polycystic ovary syndrome (PCOS) are abnormal follicular development and ovulatory dysfunction, which are caused by excessive apoptosis of ovarian granulosa cells. Acupuncture has been shown to improve follicular development abnormalities in patients with PCOS, but its mechanism is unknown. This study hypothesized that the mechanism of acupuncture on follicular development abnormalities in PCOS patients is the inhibition of granulosa cell apoptosis through LncMEG3-mediated regulation of miR-21-3p. Methods A PCOS-like rat model was established using subcutaneous injection of dehydroepiandrosterone (DHEA). Acupuncture was performed on rats for 15 d (CV-4, RN-3, CV-6, SP-6 and EX-CA 1). Ovarian morphology was observed by HE staining, and sex hormone and AMH levels were detected by ELISA. Primary granulosa cells were isolated from each group of rats to assess the association of acupuncture treatment, LncMEG3, miR-21-3p, and granulosa cell apoptosis in rats with PCOS. Results LncMEG3 and miR-21-3p were highly expressed in the ovarian granulosa cells of rats with PCOS, and LncMEG3-mediated regulation of miR-21-3p was involved in the development of PCOS in rats. Silencing of MEG3 attenuated sex hormone dysregulation and ovarian histopathological changes in PCOS rats and promoted follicle cell development and maturation. In addition, silencing MEG3 increased the viability and number of granulosa cells. In addition, silencing MEG3 further inhibited early and late apoptosis of ovarian granulosa cells in PCOS rats. Acupuncture improved polycystic ovarian morphology and sex hormone levels in PCOS rats. Acupuncture intervention increased the viability and number of granulosa cells. Acupuncture intervention inhibited early and late apoptosis of ovarian granulosa cells in PCOS rats by targeting miR-21-3p via LncMEG3. Conclusion These results suggest that acupuncture can downregulate LncMEG3, thereby targeting and regulating miR-21-3p to suppress early and late granulosa cell apoptosis and normalize their proliferation. These factors ultimately compensate for abnormal follicular development. These findings shed light on the clinical potential of acupuncture as a safe treatment for follicular developmental abnormalities in PCOS. Highlights LncMEG3-mediated inhibition of miR-21-3p regulates ovarian granulosa cell apoptosis. LncMEG3 and miR-21-3p are involved in the occurrence and development of PCOS-related abnormal follicular development. CuONPs induce co-occurrence of autophagy activation and autophagic flux blockade. Acupuncture can improve the sex hormone levels and follicular development in the context of PCOS. The underlying mechanism of acupuncture in the treatment of PCOS abnormal follicular development was revealed.

Although metastasis is the major cause of death in cervical cancer, the mechanism of metastasis is still unclear. The mRNA expression and protein level of latent transforming growth factor beta binding protein 1 (LTBP1) were detected in tumor tissues and paracancerous tissues from in-house samples. Cell proliferation, cell cycle, migration, and in vivo metastasis were determined after LTBP1 was knocked down. Then, 13 drugs were screened, and the changes in cell apoptosis and proliferation and tumor metastasis were detected after drug treatment in shRNA cells. In our in-house samples, LTBP1 was lowly expressed in cervical cancer tissues. After LTBP1 knockdown, cell proliferation was increased, and the ability of in vitro migration and in vivo metastasis was enhanced. At the same time, the proportion of myeloid derived suppressor cells (MDSC) in situ increased, the proportion of T cells decreased, and transforming growth factor beta-1 (TGFβ1) signaling was activated. After carboplatin treatment, LTBP1 shRNA cell line apoptosis increased, metastasis in vivo was limited, and the proportion of MDSC in situ decreased. LTBP1 was lowly expressed in cervical cancer, and the inhibition of LTBP1 can improve the malignant degree of the tumor, and this process can be blocked by carboplatin. unclear LTBP (LTBP1 inhouse house samples cycle down Then screened knockdown increased enhanced time (MDSC decreased beta1 beta- TGFβ1 TGFβ (TGFβ1 activated limited (LTBP (TGFβ

Abstract In order to realize the rapid nondestructive detection of mildew peanut in the process of peanuts storage, hyperspectral imaging technology was proposed to detect mildew peanut. A total of 200 peanuts were selected from 5 kinds of peanuts purchased in the market for moldy treatment, and the remaining 400 peanuts were kept sterile. After completion, samples were collected with a hyperspectral instrument to obtain spectral data of the samples. According to the characteristics of the data, 10 pre-processing algorithms were used to de-noise the data, and Median Filtering (MF) had the best effect, with the recognition accuracy reaching 97.7%. GBDT, LightGBM, CatBoost and XGBoost algorithms were used to extract important feature bands in the spectral data pre-processed by MF. GBDT, LightGBM, CatBoost and XGBoost algorithms were used to model the extracted feature bands. The results showed that LightGBM is the best algorithm with a detection rate of 99.10%. Optuna algorithm was used to tune its parameters. Compared with the previous model, the running time of the optimized model was improved by about 0.25 s. The results showed that hyperspectral imaging provides an efficient and nondestructive method for detecting mildew in peanut storage.