Abstract The incidence of non-alcoholic fatty liver (NAFLD) remains high, and many NAFLD patients suffer from severe ischemia-reperfusion injury (IRI). Currently, no practical approach can be used to treat IRI. Puerarin plays a vital role in treating multiple diseases, such as NAFLD, stroke, diabetes, and high blood pressure. However, its role in the IRI of the fatty liver is still unclear. We aimed to explore whether puerarin could protect the fatty liver from IRI. C57BL/6J mice were fed with a high‐fat diet (HFD) followed by ischemia reperfusion injury. We showed that hepatic IRI was more severe in the fatty liver compared with the normal liver, and puerarin could significantly protect the fatty liver against IRI and alleviate oxidative stress. The PI3K-AKT signaling pathway was activated during IRI, while liver steatosis decreased the level of activation. Puerarin significantly protected the fatty liver from IRI by reactivating the PI3K-AKT signaling pathway. However, LY294002, a PI3K-AKT inhibitor, attenuated the protective effect of puerarin. In conclusion, puerarin could significantly protect the fatty liver against IRI by activating the PI3K-AKT signaling pathway. nonalcoholic non alcoholic (NAFLD ischemiareperfusion . (IRI) Currently diseases stroke diabetes pressure However unclear C57BL6J CBLJ C57BL 6J C BL J highfat fat HFD (HFD stress PI3KAKT PIKAKT PI3K AKT PI K activation LY294002 LY inhibitor conclusion (IRI CBL KAKT PIK LY29400 LY2940 LY294 LY29 LY2

A series of 4H-pyran derivatives were synthesized through a three-component condensation reaction in a pot using aromatic aldehyde, cyclohexanedione, and malononitrile in the dodecyl benzenesulfonic acid/H2O microemulsion system. This protocol is attractive because dodecyl benzenesulfonic acid microemulsion is superior for organic reaction due to its dual catalysis. On the one hand, dodecyl benzenesulfonic acid acts as a Brønsted acid to catalyze the reaction; on the other hand, it can form a microemulsion as surfactant to enlarge the boundary area and entrap water produced during esterification reaction. In addition, the reaction process is simple, with high liaison formation effciency, good yields, and environmentally harmless reaction conditions. The dodecyl benzenesulfonic acid/H2O microemulsion system was equally effective when used in consecutive reactions. 4Hpyran Hpyran 4H pyran H threecomponent three component aldehyde cyclohexanedione acidH2O acidHO H2O O catalysis hand addition simple effciency yields conditions reactions acidH HO

ABSTRACT To address the issue of corrosive wear resulting from the addition of desulphurization wastewater into the wet slag removal system, this study investigated the corrosive wear behavior of chain steel (specifically 17NiCrMo6 steel) in desulphurization wastewater with varying chloride concentrations. Weight loss, micro-phase characterization, and electrochemical testing methods were employed for analysis. The findings indicate that as the chloride concentration increases, the weight loss rates for both pure corrosion and corrosive wear exhibit a pattern of initial increase, followed by a decrease, and then another increase. This trend can be attributed to the fact that as the chloride concentration rises, the corrosion products become denser, thereby increasing the difficulty of the corrosion reaction. system specifically NiCrMo 17NiCrMo concentrations microphase micro phase characterization analysis increases increase decrease rises denser reaction

BiOCl nanosheets modified with AuCu nanoparticles were successfully designed and fabricated for water reduction of CO2. The AuxCuy/BiOCl composites exhibited enhanced visible light absorption ability due to a surface plasmon resonance (SPR) effect. The AuxCuy/BiOCl composites could convert carbon dioxide to ethane (C2H6), while only CO was obtained over pure BiOCl nanosheets. In this study, the rate of C2H6 production (12.2 μmol h-1 g-1) and selectivity of C2H6 (75.7%) were obtained over the Au1Cu1/BiOCl photocatalyst under simulated sunlight illumination. The AuCu nanoparticles played the dual role of electron traps and hot electron donors, facilitating efficient separation and migration of the carriers. The photocatalyst exhibited steady photocatalytic activity over the test duration of 9 h. CO2 AuxCuyBiOCl AuxCuy SPR (SPR effect C2H6, CH , C H (C2H6) study C2H 12.2 122 12 2 (12. h1 h 1 h- g1 g g-1 75.7% 757 75 7 (75.7% Au1Cu1BiOCl AuCuBiOCl Au1Cu1 Au Cu illumination donors carriers (C2H6 12. (12 g- 75.7 (75.7 Au1Cu (C2H (1 75. (75. ( (75 (7

Silicon catalysts have very low catalytic activity in polyester (PET). However, titanium catalysts have high catalytic activity in polyester. The simultaneous use of titanium and silicon catalysts is effective in reducing the activity of a single titanium catalytic base agent. In addition, the glycol salts of titanium and silicon (Ti-EG and Si-EG) prepared in the present invention for use in the polyester catalytic process can avoid the introduction of other groups of impurities during the polyester catalytic process, which would lead to premature capping of the polyester in the process of polycondensation and chain building and make it difficult to increase the molecular weight, and thus affect the quality of the polyester. It has been verified that the ratio of Ti:Si is 1:1 (mol), and total amount added to the catalyst is 0.15% of the raw material amount, and the polycondensation temperature was 260-280 °C for 60 min. Compared with the single Ti-EG catalyst, the b* value of the synthesized PET was significantly reduced, and the molecular weight and other indexes did not change too much. In addition, at the end of catalysis, the catalyst was uniformly dispersed in the reaction system, which could be used as a matting agent for PET. . (PET) However addition TiEG Ti EG SiEG Si Si-EG TiSi 11 1 1: mol, mol , (mol) 015 0 15 0.15 260280 260 280 260-28 C 6 min b reduced much catalysis system (PET (mol 01 0.1 26028 26 28 260-2 0. 2602 2 260-

Abstract Background In contemporary society, with the accelerated pace of work and life, more and more people feel different degrees of stress. Long-term stress may not only lead to insomnia, but also to mental health problems (e.g., anxiety and depression), which has a significant impact on people's quality of life and mental health. Objective This study primarily investigates the mechanism through which stress affects sleep quality among college students. Methods We conducted research on 1653 Chinese college students using four scales with high reliability and validity: stress, the Pittsburgh Sleep Quality Index, social anxiety, and rumination. Results The study found: (1) Stress can significantly and positively predict sleep quality and rumination; (2) Rumination can positively predict social anxiety; (3) Social anxiety can positively predict sleep quality; (4) Stress can affect sleep quality through social anxiety and rumination separately, and stress can also affect sleep quality through the chained mediation of rumination and social anxiety. Conclusion This study reveals the relationship and mechanisms between stress and sleep quality. It not only deepens the research on the impact of stress on sleep quality but also provides theoretical support and new methods for mental health professionals to help clients improve their sleep quality. In practice, in addition to using some common psychological intervention methods to help individuals reduce stress, we should pay more attention to how to help clients reduce rumination and social anxiety, This is significant in improving the quality of an individual's sleep. society Longterm Long term insomnia e.g., eg e g (e.g. depression, depression , depression) peoples s 165 validity Index found 1 (1 2 (2 3 (3 4 (4 separately practice individual e.g. (e.g 16 ( e.g

The Reformation had a profound impact on hermeneutical practices by challenging ecclesiastical authority and emphasising interpretive freedom, addressing a crucial gap in historical theology. This study aimed to assess the influence of Martin Luther's principle of self-interpretation of the Bible and Matthias Flacius' organismic methodology, which builds on that principle, on the foundations of modern hermeneutics, particularly the methodological hermeneutics represented by Schleiermacher and Dilthey. Set within the context of the 16th-century Reformation, the study conducted a rigorous textual analysis of historical theological documents, revealing a significant paradigm shift towards more inclusive and rational interpretations of sacred texts. This shift, aligning with emerging humanistic values, marked a lasting transformation in the field of hermeneutics. CONTRIBUTION: The primary contribution of this study lies in its detailed exploration of the historical roots of modern hermeneutics, highlighting the Reformation's pivotal role in shaping contemporary interpretive methodologies. By elucidating the connections between theological reforms and hermeneutical practices, this research enriches the discourse on the development of hermeneutics and underscores the enduring relevance of Reformation-era innovations. These insights provide valuable perspectives on the interplay between historical and contemporary hermeneutical theories, closely aligning with the intersection of historical theology and interpretive methodologies, thus offering a significant contribution to the field.

RESUMO Blastocystis são parasitas comuns do trato digestivo em humanos e animais, amplamente parasitados em humanos e outros primatas. Atualmente, foram propostos 17 subtipos (STs) e algumas populações denominadas STs não mamíferos e aviários (NMASTs). Para entender o status da infecção e a distribuição do genótipo de Blastocystis sp. em camundongos selvagens, este estudo usou a tecnologia PCR para estudar as amostras de DNA fecal de 111 Leopoldomys edwardsi e 117 Berylmys bowersi coletadas em Guangdong e Chongqing. Entre 228 amostras fecais, 4 amostras foram positivas para Blastocystis sp. com uma taxa de infecção total de 1,8% (4/228). Quatro amostras positivas formaram dois subtipos de ST3 e ST4, todos os quais eram genótipos zoonóticos. Este artigo tem como objetivo investigar o status da infecção e a distribuição de genótipos de Blastocystis sp. em camundongos selvagens, o que ajudará a reduzir a infecção desse patógeno em animais e, assim, reduzir o risco de transmissão zoonótica. primatas Atualmente 1 (STs NMASTs. NMASTs . (NMASTs) sp selvagens 11 Chongqing 22 fecais 18 8 1,8 4/228. 4228 4/228 (4/228) ST ST4 zoonóticos assim zoonótica (NMASTs 2 1, 422 4/22 (4/228 42 4/2 (4/22 4/ (4/2 (4/ (4 (

ABSTRACT Blastocystis are common digestive tract parasites in humans and animals, extensively parasitic in humans and other primates. They exhibit extensive genetic diversity; Currently, 17 subtypes (STs) and some populations called non mammalian and avian STs (NMASTs) have been proposed. To understand the infection status and genotype distribution of Blastocystis sp. in wild mouse, this study used PCR technology to study the fecal DNA samples of 111 Leopoldomys edwardsi and 117 Berylmys bowersi collected from Guangdong and Chongqing. Among 228 fecal samples, 4 samples were positive for Blastocystis sp., with a total infection rate of 1.8% (4/228). Four positive samples formed two subtypes of ST3 and ST4, all of which were zoonotic genotypes. This article aims to investigate the infection status and genotype distribution of wild mouse Blastocystis sp., which will help reduce the infection of this pathogen to animals and thereby reduce their risk of zoonotic transmission. primates diversity Currently 1 (STs NMASTs (NMASTs proposed sp 11 Chongqing 22 18 8 1.8 4/228. 4228 4/228 . (4/228) ST ST4 genotypes transmission 2 1. 422 4/22 (4/228 42 4/2 (4/22 4/ (4/2 (4/ (4 (

Forkhead Box O1 (FOXO1) has been reported to play important roles in many tumors. However, FOXO1 has not been studied in pan-cancer. The purpose of this study was to reveal the roles of FOXO1 in pan-cancer (33 cancers in this study). Through multiple public platforms, a pan-cancer analysis of FOXO1 was conducted to obtained FOXO1 expression profiles in various tumors to explore the relationship between FOXO1 expression and prognosis of these tumors and to disclose the potential mechanism of FOXO1 in these tumors. FOXO1 was associated with the prognosis of multiple tumors, especially LGG (low grade glioma), OV (ovarian carcinoma), and KIRC (kidney renal clear cell carcinoma). FOXO1 might play the role of an oncogenic gene in LGG and OV, while playing the role of a cancer suppressor gene in KIRC. FOXO1 expression had a significant correlation with the infiltration of some immune cells in LGG, OV, and KIRC. By combining FOXO1 expression and immune cell infiltration, we found that FOXO1 might influence the overall survival of LGG through the infiltration of myeloid dendritic cells or CD4+ T cells. Functional enrichment analysis and gene set enrichment analysis showed that FOXO1 might play roles in tumors through immunoregulatory interactions between a lymphoid and a non-lymphoid cell, TGF-beta signaling pathway, and transcriptional misregulation in cancer. FOXO1 was associated with the prognosis of multiple tumors, especially LGG, OV, and KIRC. In these tumors, FOXO1 might play its role via the regulation of the immune microenvironment. O FOXO (FOXO1 However pancancer. pancancer pan 33 (3 study. . study) platforms low glioma, glioma , glioma) ovarian carcinoma, carcinoma carcinoma) kidney carcinoma. CD4 CD nonlymphoid non TGFbeta TGF beta pathway microenvironment (FOXO 3 (

ABSTRACT In this study, a flexible capacitive pressure sensor was developed, featuring a dielectric layer composed of a polydimethylsilane (PDMS)/BaTiO3/SrTiO3 composite material. The electrode and dielectric layers were structured with a dual microstructure, combining diagonal and sandpaper-porous elements. Additionally, nano-barium titanate (BT) powder, known for its relatively high dielectric constant, was incorporated into PDMS, along with an appropriate amount of strontium titanate (STO), to enhance the sensor’s sensitivity. The developed sensor exhibited a remarkable sensitivity of 2.681 kPa–1, with response and release times of approximately 39 ms and 61 ms, respectively. It demonstrated a low detection threshold and withstood over 5000 compression cycles, showcasing excellent repeatability. The results underscored the sensor’s robust pressure-sensing performance, making it suitable for diverse applications, including human pulse monitoring, heartbeat tracking, robot arm sensing, object weight detection, and real-time healthcare monitoring. study PDMS/BaTiO3/SrTiO3 PDMSBaTiO3SrTiO3 PDMSBaTiOSrTiO PDMS /BaTiO3/SrTiO3 BaTiO3 SrTiO3 BaTiO SrTiO (PDMS)/BaTiO3/SrTiO material microstructure sandpaperporous sandpaper porous elements Additionally nanobarium nano barium BT (BT powder constant STO, STO , (STO) sensors s 2681 2 681 2.68 kPa1 kPa 1 kPa–1 3 6 respectively 500 cycles repeatability pressuresensing sensing performance applications monitoring tracking realtime real time PDMS/BaTiO3/SrTiO PDMSBaTiO PDMSBaTiO3SrTiO BaTiO3SrTiO3 BaTiOSrTiO /BaTiO3/SrTiO (STO 268 68 2.6 kPa– 50 BaTiO3SrTiO 26 2. 5

Abstract Objective This study aimed to explore the effects of Apatinib combined with Temozolomide (TMZ) on the levels of Soluble PD-1 (sPD-1) and Soluble Programmed Death-1 Ligand (sPD-L1) in patients with drug-resistant recurrent Glioblastoma (GB). Study design A total of 69 patients with recurrent GB from September 2020 to March 2022 were recruited and assigned to the control group (n = 34) and observation group (n = 35) according to different treatment options after tumor recurrence. The control group was treated with TMZ, and the observation group was treated with Apatinib combined with TMZ. Levels of sPD-1 and spd-l1, clinical efficacy, survival time and adverse reactions were observed and compared between the two groups. Results General data including gender, age, body mass index, and combined diseases indicated no statistical significance between groups (p > 0.05). Before the intervention, sPD-1 and sPD-L1 levels were not significantly different in the two groups (p > 0.05). After interventions, levels of PD-1 and sPD-L1 levels decreased significantly (p < 0.05). The objective remission rate and clinical benefit rate of the observation group were higher and overall survival and progression-free survival were longer than those of the control group (p < 0.05). No significant difference was observed in major adverse reactions among patients (p > 0.05). Conclusions Apatinib combined with TMZ is safe and effective in the treatment of recurrent GB. The combined application of the two can reduce the levels of sPD-1 and sPD-L1, which has important clinical application value. (TMZ PD1 PD 1 PD- sPD1 sPD (sPD-1 Death1 Death Death- sPDL1 sPDL L1 L (sPD-L1 drugresistant drug resistant . (GB) 6 202 n 34 35 recurrence sPD- spdl1, spdl1 spdl spd l1, l1 l spd-l1 efficacy gender age index p 0.05. 005 0.05 0 05 0.05) intervention sPD-L interventions progressionfree progression free sPDL1, L1, value (sPD- (sPD-L (GB 20 3 spd-l 00 0.0 (sPD 2 0.

Abstract Osmotic dehydration (OD) is a widely used technique for lowering the moisture content and water activity of biological products. During OD, food is immersed in an aqueous hypertonic solution of salt and/or sugar. Food and the surrounding osmotic solution have different osmotic pressures which allows for the transportation of solute from the osmotic solution into the food product. OD could be utilized as a fortification method by addition of solutes of interest to the osmotic solution. Adding vitamins, dietary fibers, and minerals (such as calcium, iron, and zinc) to the osmotic solution can be used to create food with specific health-promoting qualities. Fortification of fruit and vegetable goods would effectively minimize and prevent diseases linked to nutritional inadequacies due to the high consumption rate of these products. OD could be a simple, affordable, and effective way to fortify food for social, economic, and health benefits. This study compiles data from existing studies dating back approximately two decades, focusing on the possibility of adding or impregnating bioactive compounds into fruits and vegetables through OD as well as the effects of combining OD with vacuum, ultrasound, and pulse electric field techniques on the incorporation of these bioactive compounds into solid food matrices. A brief overview of current OD trends is also provided, highlighting the use of lower-calorie sugar replacements to improve process efficiency and raise overall product quality. This study emphasizes the need for more research into OD to fortify, improve functionality, and incorporate nutraceutical characteristics in the food industry. (OD products andor vitamins fibers such calcium iron zinc healthpromoting promoting qualities simple affordable social economic benefits decades vacuum ultrasound matrices provided lowercalorie lower calorie quality functionality industry

Abstract Gastric cancer (GC) often develops resistance to cisplatin treatment, but while latent transforming growth factor β-binding protein (LTBP2) is recognized as a potential regulator in GC, its specific role in cisplatin resistance is not fully understood. This study investigated LTBP2’s impact on cisplatin resistance in GC. LTBP2 expression was assessed in various GC cell lines, and its correlation with cisplatin sensitivity was determined through cell viability assays. Lentivirus-mediated LTBP2 silencing in HGC-27 cells demonstrated enhanced cisplatin sensitivity, reduced cell proliferation, and inhibition of the NF-κB2/Bcl-3/cyclin D1 pathway. Additionally, transient transfection overexpressed the NFκB2 gene in LTBP2-silenced HGC-27/DDPR cells, restoring cisplatin sensitivity and upregulating p52/Bcl-3/cyclin D1. In conclusion, silencing LTBP2 could effectively inhibit cell proliferation and mitigate cisplatin resistance via the NFKB noncanonical pathway NFKB2 p52/Bcl-3/cyclin D1. These findings propose LTBP2 as a potential therapeutic target for overcoming cisplatin resistance in GC patients. (GC treatment βbinding β binding LTBP (LTBP2 understood LTBP2s LTBPs s lines assays Lentivirusmediated Lentivirus mediated HGC27 HGC 27 HGC-2 NFκB2/Bcl3/cyclin NFκB2Bcl3cyclin NFκBBclcyclin NF κB2/Bcl 3/cyclin κB2 Bcl 3 cyclin κB D Additionally NFκB LTBP2silenced LTBPsilenced silenced HGC27/DDPR HGC27DDPR HGCDDPR 27/DDPR DDPR p52/Bcl3/cyclin p52Bcl3cyclin pBclcyclin p52/Bcl p52 p conclusion patients (LTBP HGC2 2 HGC- Bcl3 κB2Bcl κBBcl 3cyclin 27DDPR p52Bcl pBcl p5

Abstract Objective: Aortic Dissection (AD) is one of the most fatal acute diseases in cardiovascular diseases, with rapid onset and progression and a high fatality rate. This study aims to investigate the clinical values of non-enhancement peripheral pulse-gating rapid magnetic resonance imaging in deterministic diagnosis of AD. Methods: Aorta magnetic resonance imaging was performed in 21 healthy volunteers at a 1.5t MR scanner sequences including cardiac-gated and peripheral pulse-gated True-FISP and HASTE were carried out separately. Acquisition Time (TA), Signal to Noise Ratio (SNR), Contrast Noise Ratio (CNR), and entirety of vessel wall blood flow artifacts were measured and compared. A total of 56 AD cases were displayed by non-enhancement peripheral pulse-gating fast MR imaging, and the results were compared with pathological findings or CTA of the aorta. The dissection rupture, tear film, true and false lumen, thrombosis, hydropericardium, and the main branches of AD were evaluated respectively. Results: There were no significant differences in SNR, CNR, entirety of the vessel wall, and blood flow artifact between cardiac-gated and peripheral pulse-gated fast MR imaging. Non-enhancement pulse-gated fast scanning takes less TA time. By the pulse-gated non-enhancement fast MR imaging, the dissection rupture, tear film, true and false cavity, thrombosis, hydropericardium, and the main branches of aortic dissection were shown clearly. Multi-planar and multi-angle scans helped to show the extent of entrapment rupture, whereas partial complex tears or bi-directional tears were slightly less well visualized. Conclusion: Non-enhancement peripheral pulse-gated rapid magnetic resonance imaging can be used for deterministic diagnosis of AD. Objective (AD rate nonenhancement non enhancement pulsegating pulse gating Methods 2 15t t 1 5t cardiacgated cardiac gated pulsegated TrueFISP True FISP separately TA, , (TA) SNR (SNR) CNR (CNR) 5 aorta rupture film lumen thrombosis hydropericardium respectively Results Nonenhancement Non time cavity clearly Multiplanar Multi planar multiangle multi angle bidirectional bi directional visualized Conclusion (TA (SNR (CNR

Abstract Background Myocardial fibrosis (MF) occurs throughout the onset and progression of cardiovascular disease, and early diagnosis of MF is beneficial for improving cardiac function, but there is a lack of research on early biomarkers of MF. Objectives Utilizing bioinformatics techniques, we identified potential biomarkers for MF. Methods Datasets related to MF were sourced from the GEO database. After processing the data, differentially expressed genes were screened. Differentially expressed genes were enriched, and subsequently, protein-protein interaction (PPI) was performed to analyze the differential genes. The associated miRNAs and transcription factors were predicted for these core genes. Finally, ROC validation was performed on the core genes to determine their specificity and sensitivity as potential biomarkers. The level of significance adopted was 5% (p < 0.05). Results A total of 91 differentially expressed genes were identified, and PPI analysis yielded 31 central genes. Enrichment analysis showed that apoptosis, collagen, extracellular matrix, cell adhesion, and inflammation were involved in MF. One hundred and forty-two potential miRNAs were identified. the transcription factors JUN, NF-κB1, SP1, RELA, serum response factor (SRF), and STAT3 were enriched in most of the core targets. Ultimately, IL11, GADD45B, GDF5, NOX4, IGFBP3, ACTC1, MYOZ2, and ITGB8 had higher diagnostic accuracy and sensitivity in predicting MF based on ROC curve analysis. Conclusion Eight genes, IL11, GADD45B, GDF5, NOX4, IGFBP3, ACTC1, MYOZ2, and ITGB8, can serve as candidate biomarkers for MF. Processes such as cellular apoptosis, collagen protein synthesis, extracellular matrix formation, cellular adhesion, and inflammation are implicated in the development of MF. (MF disease function techniques database data screened subsequently proteinprotein (PPI Finally 5 p 0.05. 005 0.05 . 0 05 0.05) 9 3 apoptosis adhesion fortytwo forty two JUN NFκB1, NFκB1 NFκB NF κB1, κB1 κB NF-κB1 SP1 SP RELA SRF, SRF , (SRF) STAT targets Ultimately IL11 IL GADD45B GADDB GADD B GDF5 GDF NOX4 NOX IGFBP3 IGFBP ACTC1 ACTC MYOZ2 MYOZ ITGB synthesis formation 00 0.0 NF-κB (SRF IL1 0.

Resumo Fundamento A fibrose miocárdica (FM) ocorre durante o início e a progressão da doença cardiovascular, e o diagnóstico precoce da FM é benéfico para melhorar a função cardíaca, mas há uma falta de pesquisa sobre biomarcadores precoces da FM. Objetivos Utilizando técnicas de bioinformática, identificamos potenciais biomarcadores para FM. Métodos Os conjuntos de dados relacionados à FM foram obtidos do banco de dados Gene Expression Omnibus (GEO). Após o processamento dos dados, genes diferencialmente expressos foram rastreados. Genes diferencialmente expressos foram enriquecidos e, subsequentemente, interação proteína-proteína (PPI) foi realizado para analisar os genes diferenciais. Os miRNAs associados e fatores de transcrição foram previstos para esses genes centrais. Finalmente, a validação ROC foi realizada nos genes centrais para determinar sua especificidade e sensibilidade como potenciais biomarcadores. O nível de significância adotado foi de 5% (p < 0,05). Resultados Um total de 91 genes diferencialmente expressos foram identificados, e a análise PPI produziu 31 genes centrais. A análise de enriquecimento mostrou que apoptose, colágeno, matriz extracelular, adesão celular e inflamação estavam envolvidos na FM. Cento e quarenta e dois miRNAs potenciais foram identificados. Os fatores de transcrição JUN, NF-κB1, SP1, RELA, SRF e STAT3 foram enriquecidos na maioria dos alvos principais. Por fim, IL11, GADD45B, GDF5, NOX4, IGFBP3, ACTC1, MYOZ2 e ITGB8 tiveram maior precisão diagnóstica e sensibilidade na predição de FM com base na análise da curva ROC. Conclusão Oito genes, IL11, GADD45B, GDF5, NOX4, IGFBP3, ACTC1, MYOZ2 e ITGB8, podem servir como biomarcadores candidatos para FM. Processos como apoptose celular, síntese de proteína de colágeno, formação de matriz extracelular, adesão celular e inflamação estão implicados no desenvolvimento da FM. (FM cardiovascular cardíaca bioinformática GEO. GEO . (GEO) rastreados subsequentemente proteínaproteína (PPI diferenciais Finalmente 5 p 0,05. 005 0,05 0 05 0,05) 9 identificados 3 colágeno extracelular JUN NFκB1, NFκB1 NFκB NF κB1, κB1 κB NF-κB1 SP1 SP RELA STAT principais fim IL11 IL GADD45B GADDB GADD B GDF5 GDF NOX4 NOX IGFBP3 IGFBP ACTC1 ACTC MYOZ ITGB (GEO 00 0,0 NF-κB IL1 0,