In recent years, solid-state engineering has emerged as a promising method for improving the stability and potency of antibiotics and anti-inflammatory drugs. This study focuses on the design and optimization of the intercalation of levofloxacin (an antibiotic drug) and salicylic acid (an anti-inflammatory drug) into zinc-aluminium-layered double hydroxide galleries using response surface method. Release studies revealed that a burst release phenomenon was observed at the beginning of the release assay, and the pH value (in the range of 5.8-7.4) had very little influence on the levofloxacin and salicylic acid release efficiency. This indicates that zinc-aluminium-layered double hydroxide could be an effective inorganic carrier for levofloxacin and salicylic acid over a wide range of pH values. Four kinetic models were used to study the release kinetics and the drug release mechanism was also discussed. In addition, the intercalation of levofloxacin and salicylic acid into zinc-aluminium-layered double hydroxide exhibited enhanced antibacterial activity against Gram-positive Bacillus subtilis. The cell viability assay revealed non-toxic behavior of levofloxacin and salicylic acid intercalated into zinc-aluminium-layered double hydroxide against the monocyte/macrophage-like cell line. years solidstate solid state antiinflammatory anti inflammatory drugs zincaluminiumlayered zinc aluminium layered in 5.87.4 5874 5.8 7.4 5 8 7 4 5.8-7.4 efficiency values discussed addition Grampositive Gram positive subtilis nontoxic non toxic monocyte/macrophagelike monocytemacrophagelike monocyte/macrophage like monocyte macrophage line 87 5.87. 587 58 5. 74 7. 5.8-7. macrophagelike monocytemacrophage 5.87 5.8-7 5.8-

As a result of Hon Ba nature reserve survey, Hetaeria finlaysoniana, previously recorded from Thailand, Myanmar and southern China, is newly recorded from Vietnam. Description of studied plants is presented together with notes on ecology and photographic documentation. These plants were collected in southern Vietnam (Hon Ba Nature Reserve, Khanh Hoa), which is located quite far from other known localities and thus a larger distribution of this possibly overlooked species could be expected. Additionally, H. youngsayei is newly recorded from the same reserve, 540 km from the nearest previously known locality. Distribution of both species is discussed and an updated identification key for all Vietnamese members of the genus Hetaeria is presented.