ABSTRACT Objective: To investigate the impact of tenofovir disoproxil fumarate on bone mineral density and bone mineral content in children and adolescents infected with the human immunodeficiency virus. Data source: The search procedure was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement. The search was carried out until April 2022 in Medical Literature Analysis and Retrieval System Online (Medline), Embase, Cochrane Central, Latin American and Caribbean Health Sciences Literature, Web of Science, Scopus, and MedRxiv. The combination of terms used was: (Children OR Youth OR Teenagers) AND HIV AND (Tenofovir OR “Antiretroviral therapy”) AND (“Bone density” OR Osteoporosis OR Osteopenia). The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO, CRD42022312851) Data synthesis: The initial searches resulted in 1156 papers. After the exclusion of duplicate studies, three blinded reviewers analyzed the title and abstract of 563 papers, of which 57 remained to be read in full. Only nine papers met the eligibility criteria and were included in descriptive and risk-of-bias analyses. Regarding study design, four were cross-sectional, three were longitudinal before-after studies without a control group, and two were prospective cohorts. Among these nine papers, seven showed no significant association between tenofovir disoproxil fumarate use and reduced bone mass in young people. However, these papers did not have high methodological quality. Conclusions: Although most of the selected papers found no harmful effect of tenofovir disoproxil fumarate on bone mass, further primary research with higher methodological quality is needed so robust scientific evidences can be obtained. Objective virus source MetaAnalyses Meta Analyses Statement 202 Medline, Medline , (Medline) Embase Central Science Scopus MedRxiv Children Teenagers Tenofovir Antiretroviral therapy therapy” Bone Osteopenia. Osteopenia . Osteopenia) PROSPERO, PROSPERO (PROSPERO CRD42022312851 CRD synthesis 115 56 5 full riskofbias risk bias analyses design crosssectional, crosssectional cross sectional, sectional cross-sectional beforeafter before after group cohorts people However Conclusions obtained 20 (Medline CRD4202231285 11 2 CRD420223128 1 CRD42022312 CRD4202231 CRD420223 CRD42022 CRD4202 CRD420 CRD42 CRD4

RESUMO Objetivo: Investigar o impacto do tenofovir disoproxil fumarato sobre a densidade mineral óssea e o conteúdo mineral ósseo em crianças e adolescentes infectados pelo vírus da imunodeficiência humana. Fontes de dados: O procedimento de busca foi executado de acordo com o Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. A busca foi realizada até abril de 2022 nas seguintes bases de dados: Medical Literature Analysis and Retrieval System Online (Medline), Embase, Cochrane Central, Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs), Web of Science, Scopus, and MedRxiv. A combinação de termos utilizada foi: (Children OR Youth OR Teenagers) AND HIV AND (Tenofovir OR “Antiretroviral therapy”) AND (“Bone density” OR Osteoporosis OR Osteopenia). O protocolo foi registrado na base International Prospective Register of Systematic Reviews — PROSPERO (CRD42022312851). Síntese dos dados: As pesquisas iniciais resultaram em 1.156 artigos. Após a exclusão dos estudos duplicados, três revisores cegos analisaram título e resumo de 563 estudos, dos quais 57 permaneceram para leitura na íntegra. Somente nove artigos atenderam aos critérios de elegibilidade e foram incluídos para análises descritivas e de risco de viés. Com relação ao desenho dos estudos, quatro foram transversais, três foram estudos longitudinais antes-depois sem grupo controle e dois foram coortes prospectivas. Dos nove artigos, sete não mostraram associação significativa entre uso de TDF e redução de massa óssea em pessoas jovens. Entretanto, esses estudos não tiveram alta qualidade metodológica. Conclusões: Embora a maioria dos estudos selecionados não tenha encontrado efeito prejudicial do TDF sobre massa óssea, novas pesquisas primárias com maior qualidade metodológica são necessárias para que sejam obtidas evidências científicas robustas. Objetivo humana dados MetaAnalyses Meta Analyses PRISMA (PRISMA Statement 202 Medline, Medline , (Medline) Embase Central LatinoAmericana Latino Americana Lilacs, Lilacs (Lilacs) Science Scopus MedRxiv Children Teenagers Tenofovir Antiretroviral therapy therapy” Bone density Osteopenia. Osteopenia . Osteopenia) CRD42022312851. CRD42022312851 CRD (CRD42022312851) 1156 1 156 1.15 duplicados 56 5 íntegra viés transversais antesdepois antes depois prospectivas jovens Entretanto Conclusões robustas 20 (Medline (Lilacs CRD4202231285 (CRD42022312851 115 15 1.1 2 CRD420223128 (CRD4202231285 11 1. CRD42022312 (CRD420223128 CRD4202231 (CRD42022312 CRD420223 (CRD4202231 CRD42022 (CRD420223 CRD4202 (CRD42022 CRD420 (CRD4202 CRD42 (CRD420 CRD4 (CRD42 (CRD4 (CRD

ABSTRACT Purpose: This study aims to compare the initial ocular discomfort symptoms resulting from trabeculectomy and Ahmed glaucoma valve implantation surgeries. Methods: A prospective comparative study was conducted. The evaluation of ocular discomfort employed a questionnaire designed to identify the frequency and severity of distinct symptoms: ocular pain, general discomfort, tearing, foreign body sensation, and burning. This questionnaire was administered prior to surgery as a baseline, and subsequently at 7, 30, and 90 days post-surgery. Simultaneously, the Ocular Surface Disease Index (OSDI) was applied at these same time intervals. Results: The study encompassed a total of 17 patients (9 undergoing trabeculectomy and 8 undergoing Ahmed glaucoma valve implantation). The Ahmed glaucoma valve implantation group exhibited higher tearing levels at baseline (p=0.038). However, no statistically significant differences in symptoms were observed between the two surgeries at 7 and 30 days post-surgery. At the 90-day mark following surgery, patients who had undergone trabeculectomy reported a significantly higher foreign body sensation (p=0.004). Although OSDI scores did not differ between groups at baseline, the trabeculectomy group showed significantly higher OSDI scores than the Ahmed glaucoma valve implantation group at 7, 30, and 90 days after surgery (p<0.05). Conclusion: Post-surgery, patients who had undergone trabeculectomy experienced increased foreign body sensation. Trabeculectomy appears to cause greater early postoperative ocular discomfort compared to the Ahmed glaucoma valve implantation group. Purpose Methods conducted pain burning 9 postsurgery. postsurgery post surgery. post-surgery Simultaneously (OSDI intervals Results 1 ( implantation. . implantation) p=0.038. p0038 p p=0.038 0 038 (p=0.038) However 3 90day day p=0.004. p0004 p=0.004 004 (p=0.004) p<0.05. p005 p<0.05 05 (p<0.05) Conclusion Postsurgery, Postsurgery Post Post-surgery p003 p=0.03 03 (p=0.038 p000 p=0.00 00 (p=0.004 p00 p<0.0 (p<0.05 p=0.0 (p=0.03 (p=0.00 p0 p<0. (p<0.0 p=0. (p=0.0 p<0 (p<0. p=0 (p=0. p< (p<0 p= (p=0 (p< (p= (p

Abstract This article aimed to analyze the degree of implementation of regional planning, considering care flows for cervical cancer as a defining condition, in a health region of the SUS in Bahia. This is an evaluative study, evaluating the implementation of regionalized health planning, based on a case study of the Vitória da Conquista Health Region (RSVC), state of Bahia. Twenty-nine interviews were carried out with managers and representatives of the Regional Intermanagers Commission (CIR) and 103 documents were analyzed. The evaluation matrix supported the measurement of the level of planning implementation by the municipalities, considered incipient, with three municipalities showing an intermediate level (M1, M2, and M3); only M4 reached an advanced grade. The political nature of persistent decision-making was observed, neglecting technical analysis and, consequently, not favoring access monitoring actions, which were punctual, and reducing the capacity for control and negotiation with private service providers. The challenges of management, systemic organization, and regional political context were decisive for the incipient implementation of planning given the incoherence between institutions and characteristics unfavorable to inter-municipal integration, making strategic actions necessary to strengthen the capacity for integrated planning between municipalities. condition Bahia RSVC, RSVC , (RSVC) Twentynine Twenty nine CIR (CIR 10 analyzed M1, M1 M (M1 M2 M3 M3) grade decisionmaking decision observed consequently punctual providers management organization intermunicipal inter municipal integration (RSVC 1 (M

Resumo Este artigo objetivou analisar o grau de implantação do planejamento regional, considerando como condição traçadora os fluxos assistenciais para o câncer de colo de útero, em uma região de saúde do SUS baiano. Trata-se de um estudo avaliativo, do tipo avaliação da implantação do planejamento regionalizado em saúde, a partir de um estudo de caso da Região de Saúde de Vitória da Conquista (RSVC), Bahia. Realizaram-se 29 entrevistas com gestores e representantes da Comissão Intergestores Regional (CIR) e foram analisados 103 documentos. A matriz avaliativa subsidiou a mensuração do grau de implantação do planejamento pelos municípios, considerada incipiente, com três municípios apresentando grau intermediário (M1, M2 e M3); apenas M4 atingiu o grau avançado. Observou-se o caráter político nas tomadas de decisão persistente, preterindo-se a análise técnica e, consequentemente, não favorecendo as ações de monitoramento do acesso, que foram pontuais, e reduzindo a capacidade de controle e negociação junto aos prestadores de serviços privados. Os desafios da gestão, organização sistêmica e contexto político regional foram determinantes para a incipiente implantação do planejamento ante a incoerência entre instituições e características desfavoráveis à integração intermunicipal, sendo necessárias ações estratégicas para fortalecer a capacidade de planejamento integrado entre municípios. útero baiano Tratase Trata se avaliativo RSVC, RSVC , (RSVC) Bahia Realizaramse Realizaram 2 CIR (CIR 10 documentos M1, M1 M (M1 M3 M3) avançado Observouse Observou persistente preterindose preterindo consequentemente acesso pontuais privados gestão intermunicipal (RSVC 1 (M

ABSTRACT Lectins are proteins that recognize and bind to carbohydrates in a reversible and specific manner. In this work, a lectin from Crotalaria incana L. seeds was purified by Sephadex G-50 affinity chromatography. The purified lectin was named CiL and presented affinity towards D-mannose, D-glucose, D-galactose, α-methyl-D-mannoside and derivatives. CiL was stable over a wide range of temperatures and pH values, and it was divalent cation-dependent. SDS-PAGE analysis indicated that CiL is composed of two subunits with apparent masses of 29 and 30 kDa. The amino acid sequence of five tryptic peptides was obtained through mass spectrometry. Partial primary structure data indicated the similarity between CiL and lectins from Phaseolus vulgaris, Cladrastis kentukea, Lens culinaris, Pisum sativum, Crotalaria pallida and C. juncea. CiL showed no toxicity to Artemia salina nauplii at the concentration of 2 mg/mL, thus reinforcing the potential of this protein for further studies in other biological models and elucidation of possible effects. manner work L G50 G 50 G-5 chromatography Dmannose, Dmannose D mannose, mannose D-mannose Dglucose, Dglucose glucose, glucose D-glucose Dgalactose, Dgalactose galactose, galactose D-galactose αmethylDmannoside α methyl mannoside derivatives values cationdependent. cationdependent cation dependent. dependent cation-dependent SDSPAGE SDS PAGE 3 kDa spectrometry vulgaris kentukea culinaris sativum C juncea mgmL mg mL mg/mL effects G5 5 G-

Resumen La automedicación expone a los individuos a riesgos tales como reacciones adversas, intoxicaciones, interacciones medicamentosas, fracasos terapéuticos y errores medicamentosos. En la pandemia de Covid-19, hubo un aumento en la compra y consumo de productos farmacéuticos por parte de los brasileños. El presente estudio tuvo como objetivo estimar la prevalencia y los factores asociados a la automedicación en estudiantes de un centro universitario en la región de Campo das Vertentes, Sudeste de Brasil, así como evaluar la incidencia durante la pandemia de Covid-19. El estudio tuvo un diseño transversal y cuantitativo, con 248 estudiantes de un centro universitario en 2021. Los hallazgos mostraron que el 67,3% de los participantes reportaron automedicación; el 28,7% indicó un aumento en la automedicación durante la pandemia; y el 30,9% indicó el inicio en este período. Hubo una diferencia significativa en: Considerarse capaz de automedicarse, tener el hábito de referir drogas a otras personas y consumirlas por indicación de otros. Para aquellos que incrementaron la práctica de la automedicación en la pandemia, hubo una asociación con el hábito de indicar drogas a otras personas. Para aquellos que iniciaron esta práctica en el período pandémico, se asoció la capacidad de automedicación. Los resultados abren caminos para medidas educativas sobre el uso irracional de medicamentos por parte de los estudiantes de educación superior, independientemente del área de formación. adversas intoxicaciones medicamentosas medicamentosos Covid19, Covid19 Covid 19, 19 Covid-19 brasileños Vertentes Brasil Covid19. 19. cuantitativo 24 2021 673 67 3 67,3 287 28 7 28,7 309 30 9 30,9 automedicarse otros pandémico superior formación Covid1 1 Covid-1 2 202 6 67, 28, 30, Covid- 20

Abstract Self-medication exposes individuals to risks such as adverse reactions, intoxications, drug interactions, therapeutic failures and medication errors. In the COVID-19 pandemic, there was an increase in the purchase and consumption of pharmaceutical products by Brazilians. The present study aimed to estimate the prevalence and factors associated with self-medication in students of a university center in the region of Campo das Vertentes, Southeastern Brazil, as well as to evaluate the incidence during the COVID-19 pandemic. The study had a cross-sectional and quantitative design, with 248 students from a university, in 2021. The findings showed that 67.3% of the participants reported self-medication; 28.7% indicated an increase in self-medication during the pandemic; and 30.9% indicated the beginning in this period. There was a significant difference about: to consider oneself capable of self-medicating, to have the habit of referring drugs to other people and to consume them by indication of others. For those who increased the practice of self-medication in the pandemic, there was an association with the habit of indicating drugs to other people. For those who initiated this practice in the pandemic period, the capacity of self-medication was associated. The results open paths for educational measures on the irrational use of medicines by higher education students, regardless of the education area. Selfmedication Self reactions intoxications interactions errors COVID19 COVID 19 COVID-1 Brazilians selfmedication self Vertentes Brazil crosssectional cross sectional design 24 2021 673 67 3 67.3 287 28 7 28.7 309 30 9 30.9 period about selfmedicating, selfmedicating medicating, medicating self-medicating others area COVID1 1 COVID- 2 202 6 67. 28. 30. 20

Resumo A automedicação expõe os indivíduos a riscos como reações adversas, intoxicações, interações medicamentosas, falhas terapêuticas e erros de medicação. Na pandemia de Covid-19, houve aumento de compra e consumo de produtos farmacêuticos pelos brasileiros. O presente estudo teve como objetivo estimar a prevalência e os fatores associados à automedicação em estudantes de um centro universitário na região do Campo das Vertentes, Minas Gerais, bem como avaliar a incidência durante a pandemia de Covid-19. O estudo teve delineamento transversal e quantitativo, com 248 estudantes de um centro universitário em 2021. Os achados mostraram que 67,3% dos participantes relataram realizar a automedicação; 28,7% apontaram aumento da automedicação durante a pandemia; e 30,9% indicaram o início nesse período. Houve diferença significativa sobre: considerar-se capaz de se automedicar, ter costume de indicar medicamentos para outras pessoas e consumi-los por indicação de outros. Para aqueles que aumentaram a prática de automedicação na pandemia, houve associação com o hábito de indicar medicamentos para outras pessoas. Já para quem iniciou essa prática no período pandêmico, a capacidade de automedicação esteve associada. Os resultados abrem caminhos para medidas educativas sobre o uso irracional dos medicamentos pelos estudantes do ensino superior, independentemente da área de formação. adversas intoxicações medicamentosas medicação Covid19, Covid19 Covid 19, 19 Covid-19 brasileiros Vertentes Gerais Covid19. 19. quantitativo 24 2021 673 67 3 67,3 287 28 7 28,7 309 30 9 30,9 considerarse considerar automedicar consumilos consumi los outros pandêmico associada superior formação Covid1 1 Covid-1 2 202 6 67, 28, 30, Covid- 20

RESUMO Objetivo: Investigar a associação entre as dimensões do Modelo de Crenças em Saúde (MCS) e a vacinação completa para hepatite B entre trabalhadores da saúde (TS). Métodos: Estudo epidemiológico de corte transversal com TS da Atenção Primária à Saúde e Média Complexidade. Realizaram-se análises uni e bivariada a fim de testar a associação entre a variável desfecho (vacinação completa para hepatite B a partir do autorrelato) e as variáveis das dimensões do MCS. Foram calculadas razões de prevalência (RP) e seus respectivos intervalos de confiança de 95% (IC95%). Resultados: Participaram do estudo 453 TS. A prevalência de vacinação completa para hepatite B foi de 56,9%. No modelo final de análise, estiveram associadas à vacinação completa para hepatite B as variáveis: chance de pegar hepatite B (RP=1,73) – relativa à dimensão de suscetibilidade; gravidade da doença (RP=0,74) – relativa à dimensão de gravidade; diminuição do risco de absenteísmo (RP=1,29) – relativa à dimensão de benefícios; não dispêndio de tempo para se vacinar (RP=1,41) e não preocupação acerca de eventos atribuíveis à vacinação ou imunização (RP=1,43) – relativas à dimensão de barreiras. Conclusão: A completude do esquema vacinal para hepatite B, referida pelos TS investigados, revela uma prevalência abaixo da meta estabelecida pelo Ministério da Saúde, a qual acompanha o cenário nacional de baixas coberturas apresentado para outras faixas etárias. A compreensão sobre percepção de risco e gravidade da hepatite B pode contribuir para o aumento da prevalência de vacinação para essa infecção. Objetivo MCS (MCS . (TS) Métodos Complexidade Realizaramse Realizaram autorrelato RP (RP 95 IC95%. IC95 IC IC95% (IC95%) Resultados 45 569 56 9 56,9% análise RP=1,73 RP173 1 73 (RP=1,73 suscetibilidade RP=0,74 RP074 0 74 (RP=0,74 RP=1,29 RP129 29 (RP=1,29 benefícios RP=1,41 RP141 41 (RP=1,41 RP=1,43 RP143 43 (RP=1,43 barreiras Conclusão investigados etárias infecção (TS IC9 (IC95% 4 5 56,9 RP=1,7 RP17 7 (RP=1,7 RP=0,7 RP07 (RP=0,7 RP=1,2 RP12 2 (RP=1,2 RP=1,4 RP14 (RP=1,4 (IC95 56, RP=1, RP1 (RP=1, RP=0, RP0 (RP=0, (IC9 RP=1 (RP=1 RP=0 (RP=0 (IC RP= (RP=

ABSTRACT Objective: To investigate the association between the dimensions of the Health Belief Model (HBM) and complete vaccination for hepatitis B among healthcare workers (HCW). Methods: Cross-sectional epidemiological study with HCW in Primary Health and Medium Complexity Care. Univariate and bivariate analyses were performed to test the association between the outcome variable (complete vaccination for hepatitis B based on self-report) and the variables of the HBM dimensions. Prevalence ratio (PR) and its respective 95% confidence intervals (95%CI) were calculated. Results: 453 HCW participated. The prevalence of complete vaccination for hepatitis B was 56.9%. In the final analysis model, the following variables were associated with complete vaccination for hepatitis B: chances of having hepatitis B (PR=1.73) – related to the susceptibility dimension; disease severity (PR=0.74) – related to severity; reduced risk of absenteeism (PR=1.29) – related to benefits; not spending time to get vaccinated (PR=1.41) and not worrying about Events Supposedly Attributable to Vaccination or Immunization (PR=1.43) – related to barriers. Conclusions: The completeness of the hepatitis B vaccination schedule, reported by the investigated HCW, reveals the prevalence is below the target established by the Ministry of Health, which follows the national scenario of low coverage presented for other age groups. Understanding the risk perception and severity of hepatitis B can contribute to increasing the prevalence of vaccination for this infection. Objective (HBM HCW. . (HCW) Methods Crosssectional Cross sectional Care selfreport self report self-report PR (PR 95 95%CI 95CI CI (95%CI calculated Results 45 participated 569 56 9 56.9% model PR=1.73 PR173 1 73 (PR=1.73 dimension PR=0.74 PR074 0 74 (PR=0.74 PR=1.29 PR129 29 (PR=1.29 benefits PR=1.41 PR141 41 (PR=1.41 PR=1.43 PR143 43 (PR=1.43 barriers Conclusions schedule groups infection (HCW 4 5 56.9 PR=1.7 PR17 7 (PR=1.7 PR=0.7 PR07 (PR=0.7 PR=1.2 PR12 2 (PR=1.2 PR=1.4 PR14 (PR=1.4 56. PR=1. PR1 (PR=1. PR=0. PR0 (PR=0. PR=1 (PR=1 PR=0 (PR=0 PR= (PR=

ABSTRACT Objective: To investigate the association between the dimensions of the Health Belief Model (HBM) and complete vaccination for hepatitis B among healthcare workers (HCW). Methods: Cross-sectional epidemiological study with HCW in Primary Health and Medium Complexity Care. Univariate and bivariate analyses were performed to test the association between the outcome variable (complete vaccination for hepatitis B based on self-report) and the variables of the HBM dimensions. Prevalence ratio (PR) and its respective 95% confidence intervals (95%CI) were calculated. Results: 453 HCW participated. The prevalence of complete vaccination for hepatitis B was 56.9%. In the final analysis model, the following variables were associated with complete vaccination for hepatitis B: chances of having hepatitis B (PR=1.73) – related to the susceptibility dimension; disease severity (PR=0.74) – related to severity; reduced risk of absenteeism (PR=1.29) – related to benefits; not spending time to get vaccinated (PR=1.41) and not worrying about Events Supposedly Attributable to Vaccination or Immunization (PR=1.43) – related to barriers. Conclusions: The completeness of the hepatitis B vaccination schedule, reported by the investigated HCW, reveals the prevalence is below the target established by the Ministry of Health, which follows the national scenario of low coverage presented for other age groups. Understanding the risk perception and severity of hepatitis B can contribute to increasing the prevalence of vaccination for this infection.

RESUMO Objetivo: Investigar a associação entre as dimensões do Modelo de Crenças em Saúde (MCS) e a vacinação completa para hepatite B entre trabalhadores da saúde (TS). Métodos: Estudo epidemiológico de corte transversal com TS da Atenção Primária à Saúde e Média Complexidade. Realizaram-se análises uni e bivariada a fim de testar a associação entre a variável desfecho (vacinação completa para hepatite B a partir do autorrelato) e as variáveis das dimensões do MCS. Foram calculadas razões de prevalência (RP) e seus respectivos intervalos de confiança de 95% (IC95%). Resultados: Participaram do estudo 453 TS. A prevalência de vacinação completa para hepatite B foi de 56,9%. No modelo final de análise, estiveram associadas à vacinação completa para hepatite B as variáveis: chance de pegar hepatite B (RP=1,73) – relativa à dimensão de suscetibilidade; gravidade da doença (RP=0,74) – relativa à dimensão de gravidade; diminuição do risco de absenteísmo (RP=1,29) – relativa à dimensão de benefícios; não dispêndio de tempo para se vacinar (RP=1,41) e não preocupação acerca de eventos atribuíveis à vacinação ou imunização (RP=1,43) – relativas à dimensão de barreiras. Conclusão: A completude do esquema vacinal para hepatite B, referida pelos TS investigados, revela uma prevalência abaixo da meta estabelecida pelo Ministério da Saúde, a qual acompanha o cenário nacional de baixas coberturas apresentado para outras faixas etárias. A compreensão sobre percepção de risco e gravidade da hepatite B pode contribuir para o aumento da prevalência de vacinação para essa infecção.

Resumo Este artigo objetivou analisar o grau de implantação do planejamento regional, considerando como condição traçadora os fluxos assistenciais para o câncer de colo de útero, em uma região de saúde do SUS baiano. Trata-se de um estudo avaliativo, do tipo avaliação da implantação do planejamento regionalizado em saúde, a partir de um estudo de caso da Região de Saúde de Vitória da Conquista (RSVC), Bahia. Realizaram-se 29 entrevistas com gestores e representantes da Comissão Intergestores Regional (CIR) e foram analisados 103 documentos. A matriz avaliativa subsidiou a mensuração do grau de implantação do planejamento pelos municípios, considerada incipiente, com três municípios apresentando grau intermediário (M1, M2 e M3); apenas M4 atingiu o grau avançado. Observou-se o caráter político nas tomadas de decisão persistente, preterindo-se a análise técnica e, consequentemente, não favorecendo as ações de monitoramento do acesso, que foram pontuais, e reduzindo a capacidade de controle e negociação junto aos prestadores de serviços privados. Os desafios da gestão, organização sistêmica e contexto político regional foram determinantes para a incipiente implantação do planejamento ante a incoerência entre instituições e características desfavoráveis à integração intermunicipal, sendo necessárias ações estratégicas para fortalecer a capacidade de planejamento integrado entre municípios.

Abstract This article aimed to analyze the degree of implementation of regional planning, considering care flows for cervical cancer as a defining condition, in a health region of the SUS in Bahia. This is an evaluative study, evaluating the implementation of regionalized health planning, based on a case study of the Vitória da Conquista Health Region (RSVC), state of Bahia. Twenty-nine interviews were carried out with managers and representatives of the Regional Intermanagers Commission (CIR) and 103 documents were analyzed. The evaluation matrix supported the measurement of the level of planning implementation by the municipalities, considered incipient, with three municipalities showing an intermediate level (M1, M2, and M3); only M4 reached an advanced grade. The political nature of persistent decision-making was observed, neglecting technical analysis and, consequently, not favoring access monitoring actions, which were punctual, and reducing the capacity for control and negotiation with private service providers. The challenges of management, systemic organization, and regional political context were decisive for the incipient implementation of planning given the incoherence between institutions and characteristics unfavorable to inter-municipal integration, making strategic actions necessary to strengthen the capacity for integrated planning between municipalities.

Abstract Essential oils (EOs) are natural compounds extracted from plants that exhibit antimicrobial and antioxidant properties. and therefore attract interest as additives in the food industry. especially food for special populations. In the case of children diagnosed with Cerebral Palsy. another factor has to be considered. such as the consistency of food. This study evaluated consumer acceptability of infant food with oregano essential oil by children diagnosed with cerebral palsy and a questionnaire was applied to assess consumption habits and profile of the studied population. Samples were evaluated according to odor. flavor. color. and texture acceptability. Consumers were divided by days. with 35 children each day per sample (CONT without essential oil and EO with different concentration of oregano essential oil). Total number of children was 103. In relation to acceptability of color. odor and flavor of the CONT and EO-0.01% received higher grades. the infant food with 0.05% oregano essential oil showed lower scores compared with the other treatments. However. in relation to acceptability. all samples received satisfactory scores. In relation to texture. differences were not observed. The use of oregano essential oil could be an alternative for the development of an infant food. EOs (EOs properties industry populations Palsy considered population color days 3 oil. . oil) 103 EO0.01% EO001 0.01% 0 01 EO-0.01 grades 005 05 0.05 treatments However observed 10 EO0 EO0.01 EO00 001 0.01 EO-0.0 00 0.0 1 EO0.0 EO-0. 0. EO0. EO-0 EO-

ABSTRACT: The knowledge of water consumption and the efficiency of water use by crops is extremely important in the elaboration of agronomic and hydraulic projects of hydroponic systems. Thus, the present study determined the water consumption and water use efficiency of ‘Biquinho’ pepper cultivated in the hydroponic system using seven levels of electrical conductivity of the nutrient solution (ECsol) of 2.70, 3.64, 4.58, 5.28, 6.09, 6.90, and 7.77 dS m-1 and six replicates in randomized blocks. The hydroponic system used was the Nutrient Film Technique (NFT). The water consumption per plant was determined at an interval of ten days in the crop cycle (120 days after transplanting). The maximum mean daily water consumption was equal to 5.88 L plant-1 during the period 111-120 DAT, for ECsol of 4.58 dS m-1. The maximum water consumption for the crop cycle (120 DAT) was 275.66 L per plant for an estimated ECsol = 4.11 dS m-1. The highest water use efficiency (WUE), based on the total production of fruit fresh mass (ripe and unripe fruits) of ‘Biquinho’ pepper was 10.84 kg m-3 up to an estimated ECsol of 5.18 dS m-1, with an exponential reduction thereafter. The salinity of the nutrient solution, biomass production, and evapotranspiration are factors that influence the most water consumption of ‘Biquinho’ pepper. ABSTRACT systems Thus ‘Biquinho Biquinho (ECsol 270 2 70 2.70 364 3 64 3.64 458 4 58 528 5 28 5.28 609 6 09 6.09 690 90 6.90 777 7 77 7.7 m1 m 1 m- blocks NFT. NFT . (NFT) 120 (12 transplanting. transplanting transplanting) 588 88 5.8 plant1 plant- 111120 111 111-12 DAT 4.5 m1. 1. 27566 275 66 275.6 411 11 4.1 WUE, WUE , (WUE) ripe fruits 1084 10 84 10.8 m3 518 18 5.1 m1, 1, thereafter 27 2.7 36 3.6 45 52 5.2 60 0 6.0 69 9 6.9 7. (NFT 12 (1 8 5. 11112 111-1 4. 2756 275. 41 (WUE 108 10. 51 2. 3. 6. ( 1111 111-

RESUMO: O conhecimento do consumo hídrico e eficiência do uso da água pelas culturas são extremamente importantes para o dimensionamento de sistemas agronômicos e projeto hidráulico dos sistemas hidropônicos. Neste contexto, o presente estudo determinou o consumo de água e a eficiência do uso da água da pimenta ‘Biquinho’ cultivada no sistema hidropônico utilizando sete níveis de condutividade elétrica da solução nutritiva (CEsol) de 2,70, 3,64, 4,58, 5,28, 6,09, 6,90 e 7,77 dS m-1 e seis repetições em blocos casualizados. O sistema hidropônico utilizado foi a técnica do fluxo laminar de nutrientes. O consumo hídrico por planta foi determinado em um intervalo de dez dias no ciclo da cultura (120 dias após o transplantio). O consumo hídrico médio diário máximo foi igual a 5,88 L planta-1 no período de 111-120 DAT, para a CEsol de 4,58 dS m-1. O consumo máximo de água para o ciclo da cultura (120 DAT) foi de 275,66 L por planta para uma estimada CEsol = 4,11 dS m-1. A maior eficiência do uso da água (EUA) observada foi de 10,84 kg m-3 (frutos maduros e não maduros) até ao CEsol estimada de 5,18 dS m-1, com posterior redução exponencial. A salinidade da solução nutritiva, a produção de biomassa e a evapotranspiração são fatores que mais influenciam o consumo de água da pimenta ‘Biquinho’. RESUMO hidropônicos contexto ‘Biquinho Biquinho (CEsol 270 2 70 2,70 364 3 64 3,64 458 4 58 528 5 28 5,28 609 6 09 6,09 690 90 6,9 777 7 77 7,7 m1 m 1 m- casualizados nutrientes 120 (12 transplantio. transplantio . transplantio) 588 88 5,8 planta1 planta- 111120 111 111-12 DAT 4,5 m1. 1. 27566 275 66 275,6 411 11 4,1 EUA (EUA 1084 10 84 10,8 m3 frutos 518 18 5,1 m1, 1, exponencial ‘Biquinho. 27 2,7 36 3,6 45 52 5,2 60 0 6,0 69 9 6, 7, 12 (1 8 5, 11112 111-1 4, 2756 275, 41 108 10, 51 2, 3, ( 1111 111-

RESUMO: O objetivo deste trabalho foi determinar a composição nutricional, atividade antioxidante e teor de compostos fenólicos totais de farinhas de batata-doce de diferentes cultivares: batata-doce Beauregard (FB) e batata-doce comum, cv. Brazlândia Rosada (FC). Foram realizadas as análises de lipídeos, proteínas, umidade, carboidratos, pH, acidez titulável, fibras, cinzas, ferro, zinco, betacaroteno, vitamina A e determinação do valor calórico. Também foram determinadas a atividade antioxidante, pelos métodos DPPH (2,2-difenil-1-picril-hidrazil), ABTS (2,2-azinobis (3-etilbenzotiazolina-6-ácido sulfônico) e FRAP (Ferric Reducing Antioxidant Power), e compostos fenólicos totais. A FC apresentou maiores teores de carboidratos, cinzas, fibras, pH e atividade antioxidante pelo método ABTS. Os teores de proteínas e zinco foram semelhantes entre as duas farinhas. A FB apresentou maiores teores de umidade, valor calórico, lipídeos, ferro, capacidade sequestradora de radicais DPPH e atividade antioxidante pelo método FRAP, compostos fenólicos totais, conteúdo de betacaroteno e vitamina A. Os dados revelaram uma boa composição nutricional para ambas as farinhas analisadas. O destaque para a farinha da batata-doce Beauregard é maior em relação ao seu teor de betacaroteno e ferro. Sendo a farinha obtida pela batata-doce Beauregard uma boa fonte de pró-vitamina A, além de ser fonte de fibras.

ABSTRACT: This research determined the nutritional composition, antioxidant activity and total phenolic compound content of sweet potato flour from different cultivars: Beauregard cv. sweet potato (BF) and the common sweet potato Brazlândia Rosada cv. (CF). Total lipids, proteins, moisture, carbohydrates, pH, titratable acidity, fiber, ash, iron, zinc, beta-carotene, vitamin A and determination of caloric value were analyzed. Antioxidant activity and total phenolic compounds were also determined by the DPPH (2,2-diphenyl-1-picryl-hydrazyl), ABTS (2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) and FRAP (Ferric Reducing Antioxidant Power) methods. CF showed higher levels of carbohydrates, ash, fiber, pH and antioxidant activity by the ABTS method. Protein and zinc contents were similar between the two flours. BF had higher moisture content, caloric value, lipids, iron, DPPH radical scavenging capacity and antioxidant activity by the FRAP method, as well as total phenolic compounds, beta-carotene and vitamin A content. The data revealed good nutritional composition for both analyzed flours. The Beauregard flour can be highlightedregarding its higher beta-carotene and iron content. Moreover, the Beauregard sweet potato flour is a good source of provitamin A, in addition to being a source of fiber.

ABSTRACT Background: Chagas disease is gaining importance in the Brazilian Amazon region as a differential diagnosis of febrile syndrome. The most recent microoutbreak occurred in Ipixuna, in Amazonas state. Methods: An epidemiological survey was conducted using parasitological and serological tests, and electrocardiographic analysis. Results: The patients belonged to one family and had ingested açaí acquired from Ipixuna. All patients reported fever and initially a thick blood smear test was done to identify Trypanosoma cruzi. Benznidazole treatment was administered to all patients. Conclusions: Knowledge of the epidemiological dynamics of Chagas disease allows us to improve control and management measures for this disease.

BACKGROUND The lepromatous pole is a stigmatising prototype for patients with leprosy. Generally, these patients have little or no symptoms of peripheral nerve involvement at the time of their diagnosis. However, signs of advanced peripheral neuropathy would be visible during the initial neurological evaluation and could worsen during and after multidrug therapy (MDT). Disabilities caused by peripheral nerve injuries greatly affect these patients’ lives, and the pathophysiological mechanisms underlying nerve damage remain unclear. OBJECTIVES To evaluate the outcome of peripheral neuropathy in patients with lepromatous leprosy (LL) and persistent neuropathic symptoms years after completing MDT. METHODS We evaluated the medical records of 14 patients with LL who underwent nerve biopsies due to worsening neuropathy at least four years after MDT. FINDINGS Neuropathic pain developed in 64.3% of the patients, and a neurological examination showed that most patients had alterations in the medium- and large-caliber fibers at the beginning of treatment. Neurological symptoms and signs deteriorated despite complete MDT and prednisone or thalidomide use for years. Nerve conduction studies showed that sensory nerves were the most affected. MAIN CONCLUSIONS Patients with LL can develop progressive peripheral neuropathy, which continues to develop even when they are on long-term anti-inflammatory and immunosuppressive therapy. Generally diagnosis However . (MDT) lives unclear (LL 1 643 64 3 64.3 medium largecaliber large caliber treatment affected longterm long term antiinflammatory anti inflammatory (MDT 6 64.

Abstract Introduction Tinnitus is a disorder that affects 10 to 15% of de world's population. Sound therapy performed through hearing aids (HAs) with integrated sound generator (SG) is one of the forms of tinnitus treatment. Objective To analyze the effectiveness of four masking noises in relieving tinnitus in individuals with mild and moderate bilateral sensorineural hearing loss and their influence in speech perception. Methods The participants were 35 individuals with tinnitus and mild and moderate bilateral sensorineural hearing loss, divided into four groups. All groups underwent HA and SG adaptation, being regulated in the combined mode (HA and SG). In group 1 (G1), the white noise stimulus was applied, in group 2 (G2), pink noise was applied, in group 3 (G3), speech noise, and in group 4 (G4), the high tone was applied. All patients were subjected to the following procedures: audiological diagnosis, acuphenometry, tinnitus handicap inventory (THI), visual analogue scale (VAS), and hearing in noise test (HINT). The procedures were performed prior to and after hearing intervention, and after 3 months of use of HA and SG. Results All groups presented a statistically significant difference for the THI, VAS, and HINT pre and postintervention. In the case of the HINT, only pink noise presented a significant difference. However, in the comparation among groups there was no significant difference. Conclusion The present study made it possible to conclude that the four noises were equally effective in relieving tinnitus, with no statistically significant differences between the analyzed groups.

Resumo: Introdução: As mudanças de vida do estudante quando ingressa na Faculdade de Medicina tornam os primeiros anos os mais vulneráveis para desenvolver estresse psicológico e suas consequências. Em 2020, essa condição se agravou devido à pandemia de Sars-CoV-2. Para dar suporte aos alunos, várias escolas médicas desenvolvem programas de mentoria, entretanto a adesão deles costuma ser baixa. Objetivo: Este estudo teve como objetivos criar um modelo de mentoria - denominada “Mentoria de Acolhimento” - como suporte psicossocial e pedagógico aos alunos ingressantes, e estudar seu processo de implementação e os resultados para maior adesão e efetividade. Método: Com um desenho metodológico do campo da ciência da implementação, utilizaram-se técnicas e instrumentos de pesquisas qualitativas e quantitativas para compor um estudo de métodos mistos. Obtiveram-se os dados qualitativos em reuniões com os mentores e os dados quantitativos em questionários eletrônicos anônimos para os alunos. Os encontros dos grupos de mentoria foram previstos na grade curricular obrigatória, em horários predeterminados nos quatro meses do primeiro semestre da graduação. Analisaram-se os dados qualitativos por meio da técnica de análise temática, e os dados quantitativos foram examinados de modo descritivo. Resultado: Participaram da Mentoria de Acolhimento 147 alunos (77% dos ingressantes). Identificaram-se os seguintes facilitadores de implementação: inclusão automática de todos os alunos nos grupos, inserção na grade, qualidade do mentor e disposição dos discentes para a mentoria. Observaram-se as seguintes barreiras: falhas na comunicação com os alunos, não realização de encontros por mentores, atividades extracurriculares no horário previsto para a mentoria e o modo presencial remoto. A experiência foi avaliada como positiva por alunos e mentores, verificando-se ganhos de desempenho acadêmico, em conhecer o cotidiano escolar e lidar com aspectos emocionais e relacionais da vida de estudante. Conclusão: A Mentoria de Acolhimento ajudou a integração do aluno ingressante na faculdade. Mostrou-se adequada em termos de modelo e resultados, mas requer aprofundamento dos estudos de impacto na formação médica.

Abstract: Introduction: Upon entering medical school the student undergoes life changes that make the first years the most crucial in terms of vulnerability to developing psychological stress and the associated consequences. In 2020, this condition was aggravated due to the SARS-COV-2 pandemic. To offer students more support, many medical schools have encouraged them to participate in mentoring programs, however student adherence is typically low. Objective: To create a mentoring model - called “Welcome Mentoring” - as a psychosocial and pedagogical support for incoming students, and study its implementation process and results, with the aim of achieving greater adherence and effectiveness. Methodology: Using a methodological design from the field of implementation science, qualitative and quantitative research techniques and instruments were combined to form a mixed-methods study. Qualitative data were obtained in meetings with mentors, and quantitative data through anonymous electronic questionnaires for students. The meetings of the mentoring groups were foreseen in the mandatory curricular schedule, at predetermined times during the four months of the first semester of the undergraduate course. Qualitative data were analyzed with thematic analysis technique, and quantitative data were analyzed descriptively. Results: 147 students participated in the Welcome Mentoring (77% participation). The factors that facilitated the implementation were: the automatic inclusion of all students in the groups, insertion in the curriculum, quality of the mentor, and students’ availability for mentoring. The following barriers were observed: communication failures with students, no meetings with mentors, extracurricular activities during mentoring hours, and the remote mode for meetings. The experience was evaluated as positive by students and mentors, with gains in academic performance, in learning about daily school life, and in dealing with the emotional and relational aspects of student life. Conclusion: Welcome Mentoring helped integrate incoming student into university life. It proved adequate in terms of the model and results, but requires further studies on its impact on medical education.