Pesquisa | SciELO

ABSTRACT Purpose: To assess the impact of thinness on the outcome of the percutaneous nephrolithotomy (PCNL). Materials and Methods: A matched case–control study was performed using a prospectively collected database of all patients who underwent PCNL between June 2011 and October 2021. The patients were stratified into two groups according to their phenotypic characteristics, arbitrarily defined according to their body mass index (BMI): <20 kg/m2 (Group 1, very thin patients, G<20) and ≥25 kg/m2 (Group 2, non-thin patients, G≥25). Patients were randomly matched based on Guy's Stone Score (GSS) according to case complexity at a ratio of 1:3. Results: A total of 204 patients were enrolled in this study: 51 patients (G<20) and 153 controls (G≥25). Complications occurred in 15.2% of the patients, with 5.4% of these complications classified as major complications (Clavien grade ≥ 3). According to complications there were no significant differences between the groups. The overall complication rates were 17.6% in the G<20 and 14.4% in the G≥25 (p = 0.653). The major complication rates were 3.9% in the G<20 and 5.8% in the G≥25 (p=0.429). No differences in transfusion or urinary fistula rates were found. Conclusions: In this study, very thin patients were not at a higher risk of complications when submitted to PCNL than in those with a BMI of ≥25 kg/m2. Apparently, this technique can be used in these patients, just as it is used in any other type of patient, independently of their BMI. Purpose PCNL. . (PCNL) Methods casecontrol control 201 2021 characteristics (BMI) 20 <2 kgm2 kgm kg m2 m kg/m Group 1 G20 G 25 ≥2 2 nonthin non G≥25. G25 G≥25) Guys Guy s GSS (GSS 13. 13 3. 3 1:3 Results 5 (G<20 15 (G≥25) 152 15.2 54 4 5.4 Clavien 3) 176 17 6 17.6 G<2 144 14 14.4 G≥2 p 0.653. 0653 0.653 0 653 0.653) 39 9 3.9 58 8 5.8 p=0.429. p0429 p=0.429 429 (p=0.429) found Conclusions Apparently patient (PCNL 202 (BMI < G2 1: (G<2 (G≥25 15. 5. 17. G< 14. G≥ 065 0.65 65 p042 p=0.42 42 (p=0.429 (G< (G≥2 06 0.6 p04 p=0.4 (p=0.42 (G (G≥ 0. p0 p=0. (p=0.4 p=0 (p=0. p= (p=0 (p=

https://doi.org/10.1590/s1677-5538.ibju.2024.0341

Translation, cross-cultural adaptation, and validation of health and self-management in diabetes questionnaire (HASMID-10) into Brazilian Portuguese Translation crosscultural cross cultural adaptation selfmanagement self management HASMID10 HASMID 10 (HASMID-10 HASMID1 1 (HASMID-1 (HASMID- (HASMID
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Santos-de-Araújo, Aldair Darlan

; Dibai-Filho, Almir Vieira

; Pontes-Silva, André

; Rêgo, Adriana Sousa

; Santos, Dalyla Lima dos

; Mendes Júnior, Abraão Albino

; Pereira, Fábio Henrique Ferreira

; Bacelar, Solange Negreiros de Almeida

; Oliveira, Bárbara Emanoele Costa

; Tavarez, Rudys Rodolfo de Jesus

; Bassi-Dibai, Daniela

Sao Paulo Medical Journal

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2024, Volume 142 Nº 1 elocation e2022681

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Considering the ability of the health and self-management in diabetes questionnaire (HASMID-10) to verify the impact of self-management on diabetes, we highlight its relevance to scientific research and clinical applicability. However, to date, no study has been conducted to scientifically support its use in other languages. OBJECTIVE: To translate, cross-culturally adapt, and validate the HASMID-10 into the Brazilian Portuguese. DESIGN AND SETTING: A translation, cross-cultural adaptation, and validation study conducted at Ceuma University. METHODS: Study was conducted in accordance with the Guidelines for the Process of Cross-Cultural Adaptation of Self-Report Measures and Consensus-based Standards for the Selection of Health Measurement Instruments. We included participants of both sexes diagnosed with diabetes, aged between 18 and 64 years, and without cognitive deficits or any other limitations that would prevent them from answering the questionnaire. We assessed participants using the problem areas in diabetes (PAID) scale and HASMID-10. We assessed reliability using a test-retest model with a 7-day interval between assessments. We used intraclass correlation coefficient (ICC), 95% confidence interval (CI), standard error of measurement (SEM), minimum detectable difference (MDD), Spearman correlation coefficient, and floor and ceiling effects. RESULTS: Sample comprised 116 participants, most of whom were women, overweight, non-practitioners of physical activity, and nonsmokers. We observed significant correlations (P = 0.006; rho = −0.256) between the HASMID-10 and PAID, adequate reliability (ICC = 0.780) and internal consistency (Cronbach's alpha = 0.796). No ceiling or floor effects were observed. CONCLUSION: HASMID-10 has adequate measurement properties and may be used for Brazilians. BACKGROUND selfmanagement self management HASMID10 HASMID 10 (HASMID-10 applicability However date languages OBJECTIVE translate crossculturally cross culturally adapt HASMID-1 Portuguese SETTING translation crosscultural cultural adaptation University METHODS CrossCultural Cross Cultural SelfReport Self Report Consensusbased Consensus based Instruments 1 6 years PAID (PAID HASMID10. 10. testretest test retest 7day day 7 assessments ICC, ICC , (ICC) 95 CI, CI (CI) SEM, SEM (SEM) MDD, MDD (MDD) RESULTS 11 women overweight nonpractitioners non practitioners activity nonsmokers P 0.006 0006 0 006 −0.256 0256 256 0.780 0780 780 Cronbachs Cronbach s 0.796. 0796 0.796 . 796 0.796) CONCLUSION Brazilians HASMID1 (HASMID-1 HASMID- 9 (CI (SEM (MDD 0.00 000 00 −0.25 025 25 0.78 078 78 079 0.79 79 (HASMID- 0.0 −0.2 02 2 0.7 07 (HASMID 0. −0. −0 −

https://doi.org/10.1590/1516-3180.2022.0681.r1.10042023

Image analysis of seeds and machine learning as a tool for distinguishing populations: Applied to an invasive tree species populations
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Felix, Francival Cardoso

; Chagas, Kyvia Pontes Teixeira das

; Araújo, Fernando dos Santos

; Medeiros, Josenilda Aprigio Dantas de

; Vieira, Fábio de Almeida

; Torres, Salvador Barros

; Pacheco, Mauro Vasconcelos

Acta Scientiarum. Agronomy

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2024, Volume 46 elocation e62658

Resumo: En | Texto: En | PDF: En

ABSTRACT. Invasive species threaten crops and ecosystems worldwide. Therefore, we sought to understand the relationship between the geographic distribution of species populations and the characteristics of seeds using new techniques such as seed image analysis, multivariate analysis, and machine learning. This study aimed to characterize Leucaena leucocephala (Lam.) de Wit. seeds from spatially dispersed populations using digital images and analyzed their implications for genetic studies. Seed size and shape descriptors were obtained using image analysis of the five populations. Several analyses were performed including descriptive statistics, principal components, Euclidean distance, Mantel correlation test, and supervised machine learning. This image analysis technique proved to be efficient in detecting biometric differences in L. leucocephala seeds from spatially dispersed populations. This method revealed that spatially dispersed L. leucocephala populations had different biometric seed patterns that can be used in studies of population genetic divergence. We observed that it is possible to identify the origin of the seeds from the biometric characters with 80.4% accuracy (Kappa statistic 0.755) when we applied the decision tree algorithm. Digital imaging analysis associated with machine learning is promising for discriminating forest tree populations, supporting management activities, and studying population genetic divergence. This technique contributes to the understanding of genotype-environment interactions and consequently identifies the ability of an invasive species to spread in a new area, making it possible to track and monitor the flow of seeds between populations and other sites. ABSTRACT worldwide Therefore Lam. Lam (Lam. Wit statistics components distance test L divergence 804 80 4 80.4 Kappa 0.755 0755 0 755 algorithm activities genotypeenvironment genotype environment area sites (Lam 8 80. 0.75 075 75 0.7 07 7 0.

https://doi.org/10.4025/actasciagron.v46i1.62658

Genetic Testing in Cardiomyopathy: Decoding Molecular Underpinnings and Influencing Treatment Decisions Cardiomyopathy
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Furquim, Silas Ramos

; Lipari, Layara Fernanda Vicente Pereira

; Andrade, Fernanda Almeida

; Correia, Vinícius Machado

; Olivetti, Natália Quintella Sangiorgi

; Pires, Lucas Vieira Lacerda

; Sacilotto, Luciana

; Fernandes, Fábio

; Krieger, José Eduardo

International Journal of Cardiovascular Sciences

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2024, Volume 37 elocation e20230153

Resumo: En | Texto: En | PDF: En

Abstract Cardiomyopathy is characterized by structural and functional abnormalities in the heart muscle that are not influenced by coronary disease, hypertension, valve disease, or congenital heart defects. Genetic testing, which helps diagnose the molecular bases of cardiomyopathy, can affect prognostication and clinical decisions. Recent guidelines advocate classifying cardiomyopathies based on phenotypic categories, which encompass a range of clinical presentations, underlying causes, and outcomes. Beyond deepening our grasp of the disease, genetic testing can distinguish between diseases with similar presentations, known as genocopies, which can profoundly influence treatment decisions. Genetic testing is also essential for reproductive counseling and risk evaluation among family members. Combined with advanced imaging techniques such as magnetic resonance imaging, genetic investigation offers a comprehensive understanding of the disease. Thus, as the nature of cardiomyopathies continues to be unraveled, cardiologists must stay updated on advances in genetic testing and their practical applications. disease hypertension defects cardiomyopathy decisions categories presentations causes outcomes genocopies members Thus unraveled applications

https://doi.org/10.36660/ijcs.20230153

Posicionamento do Departamento de Imagem Cardiovascular da Sociedade Brasileira de Cardiologia sobre o Uso do Strain Miocárdico na Rotina do Cardiologista – 2023 202 20 2
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Almeida, André Luiz Cerqueira

; Melo, Marcelo Dantas Tavares de

; Bihan, David Costa de Souza Le

; Vieira, Marcelo Luiz Campos

; Pena, José Luiz Barros

; Del Castillo, José Maria

; Abensur, Henry

; Hortegal, Renato de Aguiar

; Otto, Maria Estefania Bosco

; Piveta, Rafael Bonafim

; Dantas, Maria Rosa

; Assef, Jorge Eduardo

; Beck, Adenalva Lima de Souza

; Santo, Thais Harada Campos Espirito

; Silva, Tonnison de Oliveira

; Salemi, Vera Maria Cury

; Rocon, Camila

; Lima, Márcio Silva Miguel

; Barberato, Silvio Henrique

; Rodrigues, Ana Clara

; Rabschkowisky, Arnaldo

; Frota, Daniela do Carmo Rassi

; Gripp, Eliza de Almeida

; Barretto, Rodrigo Bellio de Mattos

; Silva, Sandra Marques e

; Cauduro, Sanderson Antonio

; Pinheiro, Aurélio Carvalho

; Araujo, Salustiano Pereira de

; Tressino, Cintia Galhardo

; Silva, Carlos Eduardo Suaide

; Monaco, Claudia Gianini

; Paiva, Marcelo Goulart

; Fisher, Cláudio Henrique

; Alves, Marco Stephan Lofrano

; Grau, Cláudia R. Pinheiro de Castro

; Santos, Maria Veronica Camara dos

; Guimarães, Isabel Cristina Britto

; Morhy, Samira Saady

; Leal, Gabriela Nunes

; Soares, Andressa Mussi

; Cruz, Cecilia Beatriz Bittencourt Viana

; Guimarães Filho, Fabio Villaça

; Assunção, Bruna Morhy Borges Leal

; Fernandes, Rafael Modesto

; Saraiva, Roberto Magalhães

; Tsutsui, Jeane Mike

; Soares, Fábio Luis de Jesus

; Falcão, Sandra Nívea dos Reis Saraiva

; Hotta, Viviane Tiemi

; Armstrong, Anderson da Costa

; Hygidio, Daniel de Andrade

; Miglioranza, Marcelo Haertel

; Camarozano, Ana Cristina

; Lopes, Marly Maria Uellendahl

; Cerci, Rodrigo Julio

; Siqueira, Maria Eduarda Menezes de

; Torreão, Jorge Andion

; Rochitte, Carlos Eduardo

; Felix, Alex

Arquivos Brasileiros de Cardiologia

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Dez 2023, Volume 120 Nº 12 elocation e20230646

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.36660/abc.20230646

The SISBIOTA-Diptera Brazilian Network: A long-term survey of Diptera from unexplored Brazilian Western Arc of Amazon, Cerrado, and Pantanal SISBIOTADiptera SISBIOTA Network longterm long term Amazon Cerrado
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Lamas, Carlos José Einicker

; Fachin, Diego Aguilar

; Falaschi, Rafaela Lopes

; Alcantara, Daniel Máximo Correa de

; Ale-Rocha, Rosaly

; Amorim, Dalton de Souza

; Araújo, Maíra Xavier

; Ascendino, Sharlene

; Baldassio, Letícia

; Bellodi, Carolina Ferraz

; Bravo, Freddy

; Calhau, Julia

; Capellari, Renato Soares

; Carmo-Neto, Antonio Marcelino do

; Cegolin, Bianca Melo

; Couri, Márcia Souto

; Carvalho, Claudio José Barros de

; Dios, Rodrigo de Vilhena Perez

; Falcon, Aida Vanessa Gomez

; Fusari, Livia Maria

; Garcia, Carolina de Almeida

; Gil-Azevedo, Leonardo Henrique

; Gomes, Marina Morim

; Graciolli, Gustavo

; Gudin, Filipe Macedo

; Henriques, Augusto Loureiro

; Krolow, Tiago Kütter

; Mendes, Luanna Layla

; Limeira-de-Oliveira, Francisco

; Maia, Valéria Cid

; Marinoni, Luciane

; Mello, Ramon Luciano

; Mello-Patiu, Cátia Antunes de

; Morales, Mírian Nunes

; Oliveira, Sarah Siqueira

; Patiu, Claudemir

; Proença, Barbara

; Pujol-Luz, Cristiane Vieira de Assis

; Pujol-Luz, José Roberto

; Rafael, José Albertino

; Riccardi, Paula Raile

; Rodrigues, João Paulo Vinicios

; Roque, Fabio de Oliveira

; Sallum, Maria Anice Mureb

; Santis, Marcelo Domingos de

; Santos, Charles Morphy Dias dos

; Santos, Josenilson Rodrigues dos

; Savaris, Marcoandre

; Shimabukuro, Paloma Helena Fernandes

; Silva, Vera Cristina

; Schelesky-Prado, Daniel de Castro

; Silva-Neto, Alberto Moreira da

; Camargo, Alexssandro

; Sousa, Viviane Rodrigues de

; Urso-Guimarães, Maria Virginia

; Wiedenbrug, Sofia

; Yamaguchi, Carolina

; Nihei, Silvio Shigueo

Revista Brasileira de Entomologia

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2023, Volume 67 Nº 4 elocation e20230051

Resumo: En | Texto: En | PDF: En

ABSTRACT The SISBIOTA-BRASIL was a three-year multimillion-dollar research program of the Brazilian government to document plants and animals in endangered/understudied areas and biomes in Brazil. Distributional patterns and the historical events that generated them are extensively unknown regarding Brazilian fauna and flora. This deficiency hinders the development of conservation policies and the understanding of evolutionary processes. Conservation decisions depend on precise knowledge of the taxonomy and geographic distribution of species. Given such a premise, we proposed to research the diversity of Diptera of the Brazilian western arc of Amazon, Cerrado, and Pantanal in the states of Mato Grosso, Mato Grosso do Sul, and Rondônia. Three important biomes of the South American continent characterize these Brazilian states: Amazon forest, Cerrado (Brazilian Savannah), and Pantanal. Besides their ecological relevance, these biomes historically lack intensive entomological surveys. Therefore, they are much underrepresented in the Brazilian natural history collections and in the scientific literature, which is further aggravated by the fact that these areas are being exponentially and rapidly converted to commercial lands. Our project involved over 90 collaborators from 24 different Brazilian institutions and one from Colombia among researchers, postdocs, graduate and undergraduate students, and technicians. We processed and analyzed nearly 300,000 specimens from ~60 families of Diptera collected with a large variety of methods in the sampled areas. Here, we provide a detailed overview of the genera and species diversity of 41 families treated. Our results point to a total of 2,130 species and 514 genera compiled and identified for the three states altogether, with an increase of 41% and 29% in the numbers of species and genera known for the three states combined, respectively. Overall, the 10 most species-rich families were Tachinidae, Cecidomyiidae, Tabanidae, Psychodidae, Sarcophagidae, Stratiomyidae, Bombyliidae, Syrphidae, Tephritidae, and Asilidae. The 10 most diverse in the number of genera were Tachinidae, Stratiomyidae, Asilidae, Mycetophilidae, Syrphidae, Tabanidae, Muscidae, Dolichopodidae, Sarcophagidae, and Chloropidae. So far, 111 scientific papers were published regarding taxonomic, phylogenetic, and biogeographical aspects of the studied families, with the description of 101 new species and three new genera. We expect that additional publications will result from this investigation because several specimens are now curated and being researched by specialists. SISBIOTABRASIL SISBIOTA BRASIL threeyear year multimilliondollar multimillion dollar endangeredunderstudied endangered understudied Brazil flora processes premise Sul Rondônia forest Savannah, Savannah , Savannah) relevance surveys Therefore literature lands 9 2 researchers postdocs students technicians 300000 300 000 300,00 60 ~6 Here 4 treated 2130 130 2,13 51 altogether 29 combined respectively Overall 1 speciesrich rich Tachinidae Cecidomyiidae Tabanidae Psychodidae Sarcophagidae Stratiomyidae Bombyliidae Syrphidae Tephritidae Asilidae Mycetophilidae Muscidae Dolichopodidae Chloropidae far 11 taxonomic phylogenetic specialists 30000 30 00 300,0 6 ~ 213 13 2,1 5 3000 3 0 300, 21 2,

https://doi.org/10.1590/1806-9665-rbent-2023-0051

SELECTION OF Handroanthus impetiginosus MOTHER TREES TO SUPPORT SEED COLLECTION AREAS
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Pimenta, Jéssica Maia Alves

; Souza, Wendy Mattos Andrade Teixeira de

; Ferrari, Cibele dos Santos

; Vieira, Fábio de Almeida

; Fajardo, Cristiane Gouvêa

; Pacheco, Mauro Vasconcelos

Revista Árvore

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2023, Volume 47 elocation e4706

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Handroanthus impetiginosus é uma árvore nativa brasileira ameaçada pela exploração ilegal de madeira e necessita de estratégias para fins de conservação. Devido à necessidade de obtenção de sementes de alta qualidade genética e fisiológica, objetivou-se com este estudo selecionar árvores matrizes, visando a instalação de Áreas de Coleta de Sementes (ACS) de H. impetiginosus: Para tanto, avaliou-se a diversidade genética e a qualidade fisiológica das sementes de 63 indivíduos de uma população natural localizada no estado do Rio Grande do Norte, Brasil. O conjunto de marcadores moleculares revelou que a população estudada apresenta grau intermediário de diversidade genética intrapopulacional (diversidade genética de Nei = 0,35; índice de Shannon = 0,52). Posteriormente, foi avaliada a qualidade fisiológica das sementes por meio de testes de germinação e de vigor de sementes. Deste total, 45 indivíduos produziram sementes de qualidade fisiológica alta e intermediária. Assim, os indivíduos com identidade genética de Nei < 0,72 e germinação superior a 50% podem ser selecionados como árvores matrizes e a população apresenta potencial para proposição de uma ACS. conservação objetivouse objetivou se ACS (ACS H tanto avaliouse avaliou 6 Norte Brasil 0,35 035 0 35 0,52. 052 0,52 . 52 0,52) Posteriormente total 4 intermediária Assim 072 72 0,7 50 0,3 03 3 05 0,5 5 07 7 0,

ABSTRACT Handroanthus impetiginosus is a Brazilian native tree threatened by illegal logging that needs conservation strategies. Due to the need to obtain seeds of high genetic and physiological quality, this study aimed to select mother trees, aiming at the installation of Seed Collection Areas of H. impetiginosus. Therefore, the genetic diversity and physiological quality of seeds from 63 individuals of a natural population of H. impetiginosus in Rio Grande do Norte, Brazil, were evaluated. The molecular markers revealed that the studied population has high intrapopulation genetic diversity (Nei’s genetic diversity = 0.35; and Shannon index = 0.52). Subsequently, germination and seed vigor tests evaluated the physiological quality of seeds from 63 trees. Of this total, 45 individuals produced seeds of high and intermediate physiological quality. Therefore, individuals with a Nei’s genetic distance < 0.72 and germination greater than 50% can be selected as mother trees, and the population has the potential to propose a Seed Collection Area. strategies trees H Therefore 6 Norte Brazil Neis Nei s 0.35 035 0 35 0.52. 052 0.52 . 52 0.52) Subsequently total 4 072 72 0.7 50 Area 0.3 03 3 05 0.5 5 07 7 0.

https://doi.org/10.1590/1806-908820230000006

Chitosan microparticles loaded with essential oils inhibit duo-biofilms of Candida albicans and Streptococcus mutans duobiofilms duo biofilms
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GARCIA, Lana Glerieide Silva

; ROCHA, Maria Gleiciane da

; FREIRE, Rosemayre Souza

; NUNES, Paulo Iury Gomes

; NUNES, João Victor Serra

; FERNANDES, Mirele Rodrigues

; PEREIRA-NETO, Waldemiro Aquino

; SIDRIM, José Júlio Costa

; SANTOS, Flavia Almeida

; ROCHA, Marcos Fábio Gadelha

; RODRIGUES, Lidiany Karla Azevedo

; VIEIRA, Rodrigo Silveira

; BRILHANTE, Raimunda Sâmia Nogueira

Journal of Applied Oral Science

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2023, Volume 31 elocation e20230146

Resumo: En | Texto: En | PDF: En

Abstract Oral candidiasis is a common fungal infection that affects the oral mucosa, and happens when Candida albicans interacts with bacteria in the oral microbiota, such as Streptococcus mutans, causing severe early childhood caries. C. albicans and S. mutans mixed biofilms are challenging to treat with conventional antimicrobial therapies, thus, new anti-infective drugs are required. Objective This study aimed to test a drug delivery system based on chitosan microparticles loaded with geranium and lemongrass essential oils to inhibit C. albicans and S. mutans mixed biofilms. Methodology Chitosan microparticles loaded with essential oils (CM-EOs) were obtained by spray-drying. Susceptibility of planktonic were performed according CLSI at 4 to 2,048 µg/mL. Mixed biofilms were incubated at 37ºC for 48 h and exposed to CM-EOs at 256 to 4,096 µg/mL. The antimicrobial effect was evaluated using the MTT assay, with biofilm architectural changes analyzed by scanning electron microscopy. RAW 264.7 cell was used to evaluate compound cytotoxicity. Results CM-EOs had better planktonic activity against C. albicans than S. mutans. All samples reduced the metabolic activity of mixed C. albicans and S. mutans biofilms, with encapsulated oils showing better activity than raw chitosan or oils. The microparticles reduced the biofilm on the slides. The essential oils showed cytotoxic effects against RAW 264.7 cells, but encapsulation into chitosan microparticles decreased their toxicity. Conclusion This study demonstrates that chitosan loaded with essential oils may provide an alternative method for treating diseases caused by C. albicans and S. mutans mixed biofilm, such as dental caries. mucosa microbiota caries C S therapies thus antiinfective anti infective required CMEOs CM EOs (CM-EOs spraydrying. spraydrying spray drying. drying spray-drying 2048 2 048 2,04 µgmL µg mL µg/mL ºC 25 4096 096 4,09 assay microscopy 2647 264 7 264. cytotoxicity slides cells toxicity 204 04 2,0 409 09 4,0 26 20 0 2, 40 4,

https://doi.org/10.1590/1678-7757-2023-0146

HIGH-INTENSITY INTERVAL TRAINING POSES NO RISK TO HYPERTENSIVE WOMEN
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Vieira-Souza, Lucio Marques

; Aidar, Felipe José

; Mota, Márcio Getirana

; Reis, Gracielle Costa

; Lima Júnior, Cássio Murilo Almeida

; Silva, Fábio José Antônio da

; Jesus, Joseane Barbosa de

; Azevedo, David Edson Ramos de

; Marçal, Anderson Carlos

; Santos, Jymmys Lopes dos

Revista Brasileira de Medicina do Esporte

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2023, Volume 29 elocation e2021_0321

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Introdução: O objetivo deste estudo foi avaliar se uma única sessão de treinamento intervalado de alta intensidade (HIIT) promoveria efeito hipotensor e risco cardiovascular em mulheres hipertensas, bem como aumentar a biodisponibilidade de óxido nítrico. Métodos: A amostra foi composta por 10 mulheres hipertensas (63,7 ± 10,34 anos; 66, ± 7,67 kg e 153,7 ± 9,08 cm) e a carga de treinamento foi estabelecida em 60% da velocidade aeróbica máxima. Resultados: Observamos um efeito hipotensor muito alto entre os momentos de interação durante a intervenção (Int. Pré: 122,40 ± 18,58; Int. Pós: 143,00 ± 24,90; Int. Pós 60 min.: 121,40 ± 13,87; p < 0,001, η2P = 0,569). Nenhum risco cardiovascular foi observado durante a intervenção (DP = Int. Pré: 9138,20 ± 1805,34; Int. Pós: 14849,70 ± 3387,94; Int. Pós: 60 min.: 9615,90 ± 1124,41, p < 0,001, η2P = 0,739) e não houve aumento da biodisponibilidade de óxido nítrico. Conclusões: Em conclusão, este trabalho revela que uma sessão de HIIT é capaz de gerar efeito hipotensor sem apresentar risco cardiovascular em mulheres hipertensas. Nível de evidência I; Estudo clínico randomizado de alta qualidade com ou sem diferença estatisticamente significativa, mas com intervalos de confiança estreitos .

ABSTRACT Introduction: The aim of this study was to evaluate whether a single session of high-intensity interval training (HIIT) would promote a hypotensive effect and cardiovascular risk in hypertensive women, in addition to increasing the bioavailability of nitric oxide. Methods: The sample consisted of 10 hypertensive women (63.7 ± 10.34 years; 66 ± 7.67 kg and 153.7 ± 9.08 cm) and the training load was established at 60% of the maximum aerobic speed. Results: We observed a very high hypotensive effect between the interaction moments during the intervention (Int. Pre: 122.40 ± 18.58; Int. Post: 143.00 ± 24.90; Int. Post 60min: 121.40 ± 13.87; p<0.001, η2P = 0.569). No cardiovascular risk was observed during the intervention (DP = Int. Pre: 9138.20 ± 1805.34; Int. Post: 14849.70 ± 3387.94; Int. Post 60min: 9615.90 ± 1124.41, p< 0.001, η2P = 0.739) and there was no increase in the bioavailability of nitric oxide. Conclusion: In conclusion, this work reveals that an HIIT session is capable of generating a hypotensive effect while not posing cardiovascular risk in hypertensive women. Level of evidence I; High-quality randomized clinical trial with or without statistically significant difference, but with narrow confidence intervals .

RESUMEN Introducción: El objetivo de este estudio fue evaluar si una única sesión de entrenamiento de intervalos de alta intensidad (HIIT) podría promover un efecto hipotensor y riesgo cardiovascular en mujeres hipertensas, así como aumentar la biodisponibilidad del óxido nítrico. Métodos: La muestra fue compuesta por 10 mujeres hipertensas (63,7 ± 10,34 años; 66 ± 7,67 kg y 153,7 ± 9,08 cm) y la carga de entrenamiento se estableció en el 60% de la velocidad aeróbica máxima. Resultados: Se observó un efecto hipotensor muy elevado entre los momentos de interacción durante la intervención (Int. Pre: 122,40 ± 18,58; Int. Post: 143,00 ± 24,90; Int. Post 60 min: 121,40 ± 13,87; p <0,001, η2P = 0,569). No se observó ningún riesgo cardiovascular durante la intervención (DP = Int. Pre: 9138,20 ± 1805,34; Int. Post: 14849,70 ± 3387,94; Int. Post 60 min: 9615,90 ± 1124,41, p <0,001, η2P = 0,739) y no hubo aumento de la biodisponibilidad de óxido nítrico. Conclusiones: En conclusión, este trabajo revela que una sesión de HIIT es capaz de generar efecto hipotensor sin presentar riesgo cardiovascular en mujeres hipertensas. Nivel de evidencia I; Estudio clínico aleatorizado de alta calidad con o sin diferencia estadísticamente significativa, pero con intervalos de confianza estrechos.

https://doi.org/10.1590/1517-8692202329012021_0321

10.

Predictive factors for success after supine percutaneous nephrolithotomy: an analysis of 961 patients
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El Hayek, Kayann Kaled Reda

; Perrella, Rodrigo

; Ferreira, Daniel Beltrame

; Batagello, Carlos Alfredo

; Mota, Priscila Kuriki Vieira

; Cohen, David Jacques

; Murta, Claudio Bovolenta

; Claro, Joaquim Francisco de Almeida

; Vicentini, Fabio Carvalho

Revista da Associação Médica Brasileira

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Jun 2022, Volume 68 Nº 6 Páginas 780 - 784

Resumo: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: The aim of this study was to evaluate the predictive factors for success following percutaneous nephrolithotomy in the supine position. METHODS: Patients who underwent percutaneous nephrolithotomy in the supine position from June 2011 to October 2018 were evaluated. Age, sex, body mass index, the American Society of Anesthesiologists physical status classification, hemoglobin level, number of previous surgeries, stone size, and the Guy’s Stone Score were analyzed. Success was considered if no fragments were observed on the computed tomography scan on the first postoperative day. Univariate and multivariate analyses were performed to determine significant parameters. RESULTS: We evaluated 961 patients; of them, 483 (50.2%) underwent previous stone-related surgery, and 499 (51.9%) had Guy’s Stone Score 3 or 4. The overall success rate in a single procedure was 40.7%, and complication rate was 13.7%. The univariate analysis showed that the maximum diameter of the stone (25.10±10 mm; p<0.001), previous percutaneous nephrolithotomy (OR 0.52; p<0.001), number of previous percutaneous nephrolithotomy (OR 0.15; p<0.001), the Guy’s Stone Score (OR 0.28; p<0.001), and the number of tracts (OR 0.32; p<0.001) were significant. In the multivariate analysis, the number of previous percutaneous nephrolithotomy (OR 0.54; p<0.001) and the Guy’s Stone Score (OR 0.25; p<0.001) were statically significant. CONCLUSIONS: Guy’s Stone Score and the number of previous percutaneous nephrolithotomy are predictors of success with the supine position. Complex cases and with previous percutaneous interventions may require technical improvements to achieve higher stone-free rates.

https://doi.org/10.1590/1806-9282.20211340

11.

Effect of dentifrices with different pH and fluoride concentrations on fluoride levels in biofilm and nails: an RCT
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Campos, Fernanda de Araújo Trigueiro

; Caldas, Aparecida Tharlla Leite de

; Santos, Carlus Alberto Oliveira dos

; Silva, Silmara Andrade

; Vieira, Andre Parente de Sá Barreto

; Viana Filho, José Maria Chagas

; Buzalaf, Marília Afonso Rabelo

; Sampaio, Fábio Correia

; Cardoso, Cristiane de Almeida Baldini

Brazilian Oral Research

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2022, Volume 36 elocation e043

Resumo: En | Texto: En | PDF: En

Abstract: Purpose: to evaluate the effect of dentifrice pH and fluoride concentration ([F]) on fluoride uptake on the biofilm and nails of children from a non-fluoridated area. Methods: two hundred and twenty-eight two- to four-year-old children were randomly allocated into 3 groups according to the type of dentifrice: G1: 1100 μg F/g, pH 4.5 (n = 76); G2: 750 μg F/g, pH 4.5 (n = 74); and G3: 1100 μg F/g, pH 7.0 (n = 78). Nails were collected at 4, 8, and 12 months after starting dentifrice use and biofilm was collected 5 and 60 minutes after toothbrushing. The concentrations of F in nails and biofilm were analyzed by HMDS facilitated diffusion. Data were analyzed by Kruskal-Wallis/Mann-Whitney's test and the comparison between biofilm collection times was done using Wilcoxon test (p £ 0.05). Results: a significant reduction of [F] in biofilm was observed 60 minutes after toothbrushing, regardless of the dentifrice used. However, 5 minutes after toothbrushing, G1 had a significantly higher [F] compared to G2 and G3, and 60 minutes after toothbrushing, [F] was significantly higher for G1 and G2 compared to G3. G1 and G3 had significantly higher [F] in the nails compared to G2. Conclusion: a lower dentifrice concentration is a relevant factor for the reduction of excessive fluoride intake. The use of a low-F acidified dentifrice combines the reduction of fluoride uptake with caries prevention by leading to greater incorporation of F into the biofilm over time.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0043

12.

Does the faxinal system help to maintain the genetic diversity of Curitiba prismatica (D.Legrand) Salywon & Landrum?
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Silva, Richeliel Albert Rodrigues

; Vieira, Fábio de Almeida

; Tambarussi, Evandro Vagner

; Chagas, Kyvia Pontes Teixeira das

; Watzlawick, Luciano Farinha

; Koehler, Henrique Soares

CERNE

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2022, Volume 28 elocation e-103012

Resumo: En | Texto: En | PDF: En

ABSTRACT Background: Curitiba prismatica (D.Legrand) Salywon & Landrum belongs to the Myrtaceae family and it is popularly known as murta. Endemic to the Mixed Ombrophilous Forest of south Brazil, is predominant in Faxinal System, which is a traditional agricultural system in the State of Paraná. This species also has several uses and potentials, such as wood for fence posts and essential oils with pharmacological properties. For this reason, this study aimed to select molecular markers and assess whether the Faxinal System contributes to the maintenance of the genetic diversity of the species, helping in its management and conservation. As such, 120 adult reproductive individuals were sampled, 60 in two areas managed in the Faxinal System, and 60 in two conservation areas. Results: Initially, 30 ISSR markers were selected, but only eight showed considerable variability, resulting in 68 polymorphic loci. The results show that the average diversity within populations is 80.54%. The Shannon (I) and Nei’s (He) diversity indices were 0.53 and 0.36, respectively. According to Nei’s genetic identity, the populations form two groups. With the analysis of the genetic structure of the populations, which indicated the existence of two distinct genetic groups (K = 2). Conclusion: Thus, the populations in the Faxinal System had higher rates of genetic diversity, despite constant human activity within the system. Therefore, the Faxinal System contributes to the conservation of C. prismatica genetic diversity; however, considering the economic potential of the species and to minimize impacts on the existing fragments, there is a need to work with the local population to ensure sustainable forest management of the species.

https://doi.org/10.1590/01047760202228013012

13.

HLA-DQA1*04:01 is related to a higher multiple sclerosis lesion load on T2/Flair MRI sequences
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NORO, Fabio

; ALVES-LEON, Soniza Vieira

; FONTES-DANTAS, Fabricia Lima

; VALLE BAHIA, Paulo Roberto

; ANDREIUOLO, Rodrigo Ferrone

; RUEDA LOPES, Fernanda Cristina

; PEREIRA, Valeria Coelho Santa Rita

; ABI-HAILA, Livia de Almeida Afonso

; COUTINHO, Renan Amaral

; ARAUJO, Amanda Dutra de

; MARCHIORI, Edson

Arquivos de Neuro-Psiquiatria

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Dez 2021, Volume 79 Nº 12 Páginas 1109 - 1115

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Antecedentes: A predisposição genética para a esclerose múltipla (EM) está associada a alelos HLA, principalmente o HLA-DRB1*15:01. Objetivo: Identificar associações entre lesões na ressonância magnética e características genéticas em uma coorte brasileira de pacientes com EM. Métodos: Estudamos retrospectivamente os dados de 95 pacientes consecutivos com EM. Dois observadores independentes que desconheciam os dados clínicos identificaram “black holes” e lesões realçadas pelo contraste nas sequências de ressonância magnética T1 e contaram e mediram as lesões nas sequências T2 e FLAIR (fluid attenuated inversion recovery). Os casos foram classificados de acordo com tamanho, número e volume da lesão. Os alelos HLA-DRB1, HLA-DQB1 e HLA-DQA1 e os polimorfismos de nucleotídeo único rs4774, rs3087456, rs6897932, rs731236 e rs1033182 foram identificados por amplificação de reação em cadeia da polimerase com iniciadores específicos de sequência usando o kit One Lambda Inc., Canoga Park, CA, EUA. Resultados: Os pacientes com alelo HLA-DQA1*04:01 apresentaram carga de lesão (ajustada para idade, sexo e duração da EM) acima da mediana em comparação com outros pacientes com demais alelos HLA-DQA1 (p=0,02). Não houve diferenças entre todos os outros alelos HLA e polimorfismos de nucleotídeo único e carga lesional. Conclusões: A correlação do alelo HLA-DQA1*04:01 com maior carga de lesão nas sequências de RM em T2 sugere que a presença desse alelo pode estar associada ao risco de maior gravidade da EM.

ABSTRACT Background: The genetic predisposition to multiple sclerosis (MS) is associated with HLA alleles, especially HLA-DRB1*15:01. Objective: To identify associations between findings in magnetic resonance imaging (MRI) and genetic features in a Brazilian cohort of patients with MS. Methods: We retrospectively studied data from 95 consecutive patients with MS. Two independent observers who were blinded to the clinical data identified black holes and enhanced lesions on T1 MRI sequences, and counted and measured contrast-enhanced lesions on T2 and Flair (fluid attenuation inversion recovery) sequences. Cases were classified according to lesion size, number, and volume. The HLA-DRB1, HLA-DQB1, and HLA-DQA1 alleles, and the rs4774, rs3087456, rs6897932, rs731236, and rs1033182 single nucleotide polymorphisms were identified by polymerase chain reaction amplification with sequence-specific primers using the One Lambda Inc. Kit, Canoga Park, CA, USA. Results: Patients with the HLA-DQA1*04:01 allele had lesion load (adjusted for age, sex, and MS duration) above median compared with patients with other HLA-DQA1 alleles (p=0.02). There were no differences among all the other HLA alleles and single nucleotide polymorphisms and lesion load. Conclusions: The correlation of the HLA-DQA1*04:01 allele with a higher lesion load on T2/Flair MRI sequences suggests that the presence of this allele is associated with the risk of greater MS severity.

https://doi.org/10.1590/0004-282x-anp-2020-0487 3 downloads

14.

BRAZILIAN IBD STUDY GROUP POSITION STATEMENT ON SARS-COV2 VACCINATION
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QUEIROZ, Natália Sousa Freitas

; TEIXEIRA, Fábio Vieira

; FREIRE, Caio Cesar Furtado

; MOTTA, Marina Pamponet

; VASCONCELLOS, Marcela Almeida Menezes de

; CHEBLI, Liliana Andrade

; SAAD-HOSSNE, Rogerio

Arquivos de Gastroenterologia

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Mar 2021, Volume 58 Nº 1 Páginas 1 - 4

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A vacinação em massa oferece a melhor estratégia para enfrentamento da pandemia de COVID-19, e as vacinas contra SARS-CoV2 estão sendo aprovadas em vários países para uso emergencial. No Brasil, a aprovação da vacina é esperada em breve, no entanto, existem potenciais preocupações em relação às recomendações de vacinas para populações específicas, como pacientes com doença inflamatória intestinal (DII). Para responder essas questões, o Grupo Brasileiro de Estudos IBD (GEDIIB) fornece conselhos práticos com recomendações importantes sobre as vacinas para COVID-19 na população com DII.

ABSTRACT Mass vaccination offers the best strategy to fight against COVID-19 pandemic, and SARS-CoV2 vaccines are being approved in several countries for emergency use. In Brazil, vaccine approval is expected in the next few days, however potential concerns exist regarding vaccine recommendations for specific populations, such as patients with inflammatory bowel disease (IBD). To address these questions, the Brazilian IBD Study Group (GEDIIB) provides this practical advice with key recommendations about the COVID-19 vaccines in IBD population.

https://doi.org/10.1590/s0004-2803.202100000-02 1028 downloads

15.

Association of salivary alpha-amylase with anxiety and stress in nursing professionals
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Santos, Sergio Valverde Marques dos

; Silva, Luiz Almeida da

; Terra, Fábio de Souza

; Souza, Adriele Vieira de

; Espindola, Foued Salmen

; Marziale, Maria Helena Palucci

; Teixeira, Renata Roland

; Robazzi, Maria Lucia do Carmo Cruz

Revista Latino-Americana de Enfermagem

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2021, Volume 29 elocation e3468

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Objetivo: avaliar se a alteração na atividade da alfa amilase salivar está associada à ansiedade e ao estresse dos profissionais de enfermagem hospitalar e, se a ansiedade e o estresse estão associados aos fatores sociodemográficos, epidemiológicos e laborais. Método: estudo transversal, quantitativo, desenvolvido com 210 profissionais de enfermagem de uma instituição hospitalar. Para a coleta de dados, utilizouse um questionário de caracterização dos trabalhadores, o Inventário de Ansiedade de Beck, o Inventário de Sintomas de Stress para Adultos de Lipp e as amostras de saliva coletadas durante os turnos de trabalho. Os dados foram analisados de forma descritiva e inferencial utilizando os softwares Statistical Package for the Social Science e GraphPad Prism. Resultados: a maioria dos profissionais apresentou estresse e ansiedade. As variáveis faixa etária, quantidade de filhos, uso de medicamentos e carga horária de trabalho estavam associadas à ansiedade; faixa etária, tabagismo e uso de medicamentos estavam associadas ao estresse. Observouse um aumento da atividade da alfa amilase salivar no meio do turno de trabalho. Os profissionais que tinham estresse e ansiedade apresentaram alteração significativa da alfa amilase no turno da noite. Conclusão: as alterações na atividade da alfa amilase estavam associadas à ansiedade e ao estresse dos profissionais de enfermagem, demonstrando que essa enzima pode ser um possível biomarcador de ansiedade e estresse em trabalhadores.

Objective: to assess if changes in salivary alpha-amylase activity are associated with anxiety and stress among hospital nursing professionals and whether anxiety and stress are associated with sociodemographic, epidemiological, and occupational factors. Method: cross-sectional, quantitative study, carried out with 210 nursing professionals from a hospital. For data collection, we used a questionnaire to characterize workers, Beck’s Anxiety Inventory, Lipp’s Stress Symptoms Inventory for Adults and samples and saliva samples collected in work shifts. The data were analyzed descriptively and inferentially using the software Statistical Package for the Social Science and GraphPad Prism. Results: most professionals experienced stress and anxiety. The variables age group, number of children, use of medication and workload were associated with anxiety; age group, smoking and medication use were associated with stress. An increase in the salivary alpha-amylase activity was observed in the middle of the work shift. Professionals who had stress and anxiety had significant changes in alpha-amylase in the night shift. Conclusion: changes in salivary alpha-amylase were associated with anxiety and stress among nursing professionals, indicating that this enzyme can be a possible biomarker of anxiety and stress in workers.

Objetivo: evaluar si la alteración en la actividad de la alfa amilasa salival está asociada a la ansiedad y al estrés de los profesionales de enfermería hospitalaria y, si la ansiedad y el estrés están asociados a factores sociodemográficos, epidemiológicos y laborales. Método: estudio transversal, cuantitativo, desarrollado en 210 profesionales de enfermería, en una institución hospitalaria. Para la recogida de datos, se utilizó un cuestionario de caracterización de los trabajadores, el Inventario de Ansiedad de Beck, el Inventario de Síntomas de Stress para Adultos de Lipp y las muestras de saliva recogidas durante los turnos de trabajo. Los datos fueron analizados de forma descriptiva e inferencial utilizando los softwares Statistical Package for the Social Science y GraphPad Prism. Resultados: la mayoría de los profesionales presentó estrés y ansiedad. Las variables intervalo etario, cantidad de hijos, uso de medicamentos y carga horaria de trabajo estaban asociadas a la ansiedad; el intervalo etario, el tabaquismo y el uso de medicamentos estaban asociados al estrés. Se observó un aumento de la actividad de la alfa amilasa salival en los ambientes de los turnos de trabajo. Los profesionales que tenían estrés y ansiedad presentaron alteración significativa de la alfa amilasa en el turno de la noche. Conclusión: las alteraciones en la actividad de la alfa amilasa estaban asociadas a la ansiedad y al estrés de los profesionales de enfermería, demostrando que esa enzima puede ser un posible biomarcador de ansiedad y estrés en trabajadores.

https://doi.org/10.1590/1518-8345.4859.3468 459 downloads

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