Pesquisa | SciELO

Abstract Objective: To describe cases of parafoveal chondral lesion of the femoral head in patients with femoroacetabular impingement, correlating the clinical and imaging data. Materials and Methods: This was a retrospective descriptive case series of parafoveal chondral lesion of the femoral head in 21 patients who underwent computed tomography and magnetic resonance arthrography scans of the hip, having then received an imaging-based diagnosis of femoroacetabular impingement. Results: Of the 21 patients evaluated, 15 (71%) had cam-type femoroacetabular impingement, whereas five (24%) had mixed-type impingement, and one (5%) had pincer-type impingement. Twelve patients (57%) had a low frequency of physical activity, which was significantly associated with the presence of cam-type impingement (p = 0.015). Although the extent of the lesion correlated significantly with the acetabular coverage angle (p = 0.04), it did not correlate significantly with the alpha angle or femoral head-neck offset value (p = 0.08 and p = 0.06, respectively). We also found no correlation between the extent of the lesion and the other main parameters that define the femoroacetabular impingement types. Conclusion: This was one of the largest case series of parafoveal chondral lesion of the femoral head in patients with imaging findings of femoroacetabular impingement. The extent of such lesions does not appear to correlate with the parameters of femoroacetabular impingement, with the exception of the acetabular coverage angle. Objective data Methods 2 hip imagingbased based Results evaluated 1 71% 71 (71% camtype cam type 24% 24 (24% mixedtype mixed 5% 5 (5% pincertype pincer 57% 57 (57% activity 0.015. 0015 0.015 . 0 015 0.015) 0.04, 004 0.04 , 04 0.04) headneck neck 008 08 0.0 006 06 0.06 respectively. respectively respectively) types Conclusion 7 (71 (24 (5 (57 001 0.01 01 00 0. (7 (2 (

Resumo Objetivo: Descrever casos de lesão condral parafoveal da cabeça femoral em pacientes com impacto femoroacetabular, correlacionando dados clínicos e de imagem. Materiais e Métodos: Esta foi uma série de casos descritiva retrospectiva de lesão condral parafoveal da cabeça femoral em 21 pacientes submetidos a tomografia computadorizada e artrorressonância magnética do quadril e que receberam diagnóstico por imagem de impacto femoroacetabular. Resultados: Dos 21 pacientes avaliados, 15 (71%) tiveram impacto femoroacetabular do tipo cam, enquanto cinco (24%) tiveram impacto do tipo misto e um (5%) teve impacto do tipo pincer. Doze pacientes (57%) apresentaram baixa frequência de atividade física, sendo esta significativamente associada a impacto do tipo cam (p = 0,015). Houve correlação significativa entre a extensão da lesão e o ângulo de cobertura acetabular (p = 0,04), porém, não se correlacionou significativamente com o ângulo alfa ou com o valor do deslocamento cabeça-colo femoral (p = 0,08 e p = 0,06, respectivamente). Também não encontramos correlação entre a extensão da lesão e os outros principais parâmetros que definem os tipos de impacto femoroacetabular. Conclusão: Esta foi uma das maiores casuísticas de lesão condral parafoveal da cabeça femoral em pacientes com achados de imagem de impacto femoroacetabular. A extensão dessas lesões não parece se correlacionar com os parâmetros do impacto femoroacetabular, com exceção do ângulo de cobertura acetabular. Objetivo Métodos 2 Resultados avaliados 1 71% 71 (71% 24% 24 (24% 5% 5 (5% pincer 57% 57 (57% física 0,015. 0015 0,015 . 0 015 0,015) 0,04, 004 0,04 , 04 0,04) porém cabeçacolo colo 008 08 0,0 006 06 0,06 respectivamente. respectivamente respectivamente) Conclusão 7 (71 (24 (5 (57 001 0,01 01 00 0, (7 (2 (

https://doi.org/10.1590/0100-3984.2023.0019

Impact of the COVID 19 pandemic on the student's academic performance at the School of Engineering - Universidad Nacional de Colombia, Bogotá Campus
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Monroy-Varela, Sonia Esperanza

; Gallego-Vega, Luis Eduardo

; Amórtegui-Gil, Francisco Javier

; Vega-Herrera, Jenny Marcela

; Díaz-Morales, Hernando

DYNA

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Set 2022, Volume 89 Nº spe222 Páginas 38 - 47

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Este artículo analiza el impacto de la pandemia del COVID-19 en el desempeño académico de los estudiantes de la Facultad de Ingeniería de la Universidad Nacional de Colombia - Sede Bogotá. El impacto es evaluado mediante análisis cuantitativo basado en (i) calificaciones de los estudiantes (ii), avance del plan de estudios, (iii) cursos cancelados. El análisis es complementado con una encuesta a profesores (aproximación cualitativa) para analizar algunas percepciones explicativas de los cambios académicos más relevantes durante la pandemia. Los resultados muestran un incremento significativo en el promedio de calificaciones numéricas de las asignaturas y en la probabilidad de cancelación de cursos durante la pandemia. El avance curricular semestral, promedio, de los estudiantes, creció 18% aproximadamente. Los impactos fueron diferenciados por sexo e ingresos familiares y pueden tenerse en cuenta para diseñar programas futuros. La encuesta refleja nuevas percepciones adoptadas por los profesores en torno a herramientas y metodologías de evaluación.

Abstract This paper analyzes the impact of the COVID-19 pandemic on the student's academic performance in the School of Engineering at Universidad Nacional de Colombia - Bogota Campus. The impact is assessed from a quantitative approach based on (i) student's grades, (ii) student's progress in their curriculum and (iii) dropped courses. In addition, results from a faculty survey (qualitative approach) are presented to expand some explanatory perspectives on the main academic changes during the pandemic. Results show a significant increase in the average numerical grade as well as in the probability of a course being dropped during the pandemic conditions. Furthermore, the student's average curriculum progress per semester grew approximately 18%. A differentiated academic impact, depending on sex and family income was observed which may be included in future post-pandemic programs. The survey reflects a new faculty's perspective on evaluation tools and methodologies.

https://doi.org/10.15446/dyna.v89n222.101308 231 downloads

Code infarction initiative of Bajio region, during the pandemic by COVID-19 in a reconversion hospital
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Villar-Valencia, Cristian Adrián

; Hernández-González, Martha Alicia

; Borrayo-Sánchez, Gabriela

; Celis-Quintal, Juan German

; Solorio-Meza, Sergio Eduardo

; Medina-Torres, Oscar Samuel

; Gutiérrez-Galván, Maraí Xochitl

; Rodríguez-Martínez, Braulio

; Prado-Rodríguez, Luis Humberto

; Vázquez-Morones, Ana Laura

; Alatoma-Medina, Juan Pablo

; Hernández-Estala, Jorge

; Patiño-Amaya, Aristóteles

; Magdaleno-Serrano, Hugo Ivan

; Rodríguez-Déniz, Carmen

; Arellano-Sotelo, Hugo

; Nava-Hernández, Guillermo

; Ramírez-Vázquez, Ricardo

; Chimal-Flores, Marco Antonio

; Alegría-Peredia, Emiliano

; Ramos-González, Gerardo Rubén

; Pérez-Benítez, Rigoberto

; Bermúdez-Acévez, Erik

; Valencia-Martínez, Hypatia

; Segovia-Solís, Hugo

; López-Varela, Manuel

; Monroy-Córdoba, Doryan

; Marmolejo-López, Adriana

; Báez-Montes, Alfredo

; Hernández-Cerqueda, Fabián

; Nolasco-Muñoz, Luis Ricardo

; Vargas-Ramírez, Luis Manuel

; Celis-Quintal, Juan German

; Bernal-Ruíz, Enrique Alfredo

; Delgado-Sánchez, Anabella

; Sánchez-López, José Manuel

; Bautista-López, Germán Ramón

; Acevedo-Gómez, Pablo Francisco

; Acuña-Valerio, Jorge Francisco

; González-Ortíz, Oracio

; Hernández-Padilla, Adolfo Asahel

; Solórzano-Vázquez, Marco Alejandro

; Franco-Herrera, Noel

; González, Luis Jonathan

; Reyes-Álvarez, José Miguel

; Salinas-Cavazos, Iván Rosendo

; Tiscareño-Villanueva, Ashby Daniel

; Vidrio-Villaseñor, Ramiro

; Fernández-Yáñez, Gabriel

; Meza, Ma. Guadalupe

; Nucamendi-Solórzano, Freeman Issac

; Sandoval-Uribe, José de Jesús

; Sotelo-García, Luis David

; Zamoaya-Paz, Luis Carlos

; Espriu, Donovan Fernando

; García-Rodríguez, Román

; López-Ibarra, Daniel Eugenio

; López-Valencia, Andrea Janeth

; Villar-Valencia, Cristian Adrián

; Navarro-Pérez-Macedo, Javier

Cardiovascular and metabolic science

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Set 2022, Volume 33 Nº 3 Páginas 97 - 105

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract: Introduction: Acute myocardial infarction has a high prevalence and possibility of death if timely care is not given. It is possible that treatment could be delayed during a health crisis such as the COVID-19 pandemic. Objective: The objective of this study was to evaluate the impact of the COVID-19 pandemic on the function of the infarction code in the High Specialty Medical Unit of our institution. The medical indicators of acute coronary ischemic syndrome with ST-segment elevation were compared at two times: before the COVID-19 pandemic and during it. Material and methods: An ambispective, analytical, comparative cohort study was conducted, comparing the periods of February-September 2019 and February-September 2020, in the High Specialty Medical Unit, Centro Médico del Bajío number 1, Instituto Mexicano del Seguro Social, Leon, Guanajuato, Mexico. All patients older than 18 years with clinical, electrocardiographic, and enzymatic data of acute coronary ischemic syndrome, accepted in the medical network as infarction code registered in the National Registry of Acute Coronary Ischemic Syndromes (RENASCA) electronic case report form were included in the study. Results: The independent samples t-test was used to determine the impact of the infarction code initiative based on the reperfusion therapies performed, the door-to-needle, the door-to-balloon time, and the ischemia time. There was a significant difference in the reperfusion strategy, with greater thrombolysis during the COVID-19 pandemic (57.4% versus 72.6%, odds ratio [OR] 1.97, 95% confidence interval [CI] 0.49-0.82, p < 0.001), as well as reperfusion criteria (21.03% versus 35.37%, OR 2.05, 95% CI 0.53-0.80, p < 0.0001). Mortality was not different between the time periods. Conclusions: The COVID-19 pandemic has not impacted operation of the infarction code in the High Specialty Medical Unit Centro Médico del Bajío number 1 because the medical indicators of acute coronary ischemic syndrome with ST-segment elevation did not change.

resumen está disponible en el texto completo

https://doi.org/10.35366/107622

SARS-CoV-2 Drive/Walk-Thru screening centers in Colombia: The CoVIDA Project
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Ramirez-Varela, Andrea

; Behrentz, Eduardo

; Tamayo-Cabeza, Guillermo

; Hernández, Luis Jorge

; Rodríguez-Feria, Pablo

; Lajaaj, Rachid

; León-Nuñez, Leonardo

; Buitrago, Giancarlo

; Vives-Florez, Martha

; Restrepo-Restrepo, Silvia

; Contreras-Arrieta, Sandra

; Caballero-Díaz, Yuldor

; Rodríguez-Sanchez, Daniela

; Bernal, Raquel

; Gaviria-Uribe, Alejandro

Infectio

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Mar 2022, Volume 26 Nº 1 Páginas 33 - 38

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Objetivo: El proyecto CoVIDA es una colaboración público-privada liderada por la Universidad de los Andes que contribuyó a la vigilancia epidemiológica del SARS-CoV-2 en Bogotá y municipios cercanos. Nuestro objetivo fue describir el desarrollo y rendimiento de la estrategia de tamizaje gratuito con RT-PCR mediante un modelo Drive/Walk through para SARS-CoV-2 implementado por CoVIDA. Materiales y métodos: Realizamos un análisis descriptivo de las características y desempeño de los centros de tamizaje Drive/Walk through de CoVIDA. El modelo y los indicadores de proceso para evaluar el desempeño del modelo se basaron en experiencias internacionales y la literatura científica. Se implementaron dos cen tros de tamizaje en centros comerciales del norte y sur de Bogotá. Se reportó la cantidad de pruebas tomadas, pruebas positivas y de participantes que utilizaron el modelo de acuerdo con el tipo de ocupaciones. Resultados : En total, se realizaron 36,689 pruebas RT-PCR nasofaríngeas para SARS-CoV-2 con una positividad acumulada del 5,75%. Los indicadores de proceso mostraron un excelente desempeño y una contribución importante en la reducción de las barreras de acceso a las pruebas. Conclusiones: los centros de tamizaje con modelo Drive/Walk through de CoVIDA apoyaron la vigilancia epidemiológica en población asintomática o con síntomas leves en Bogotá. Los países de ingresos bajos y medianos pueden utilizar este modelo como una estrategia innovadora y rentable para aumentar la realización de las pruebas y ayudar a mitigar la pandemia.

Abstract Objective: The CoVIDA project is a public-private collaboration led by Universidad de los Andes that contributed to the SARS-CoV-2 epidemiological surveillance in Bogotá and nearby municipalities. We aimed to describe the development and performance of the Drive/Walk-through free RT- PCR for SARS-CoV-2 testing strategy implemented by CoVIDA. Material and method: We performed a descriptive analysis of the characteristics and performance of the CoVIDA Drive/Walk-through testing centers. The model and the process indicators to assess the model’s performance were based on international experiences and scientific literature. Two screening centers were imple mented in shopping centers in the north and south of Bogotá. We reported the number of tests taken, the number of positive tests, and the number of participants that used the model by the type of occupations. Results: In total, 36,689 nasopharyngeal RT-PCR tests for SARS-CoV-2 were performed with a 5.75% cumulative positivity. Process indicators showed an excellent performance and an important contribution in reducing barriers to access to testing. Conclusions: the CoVIDA Drive/Walk-through testing centers supported the epidemiological surveillance in asymptomatic or mild-symptomatic population in Bo gotá. Low and middle-income countries can use this model as a cost-effective and innovative solution strategy to intensify testing and help mitigate the pandemic.

https://doi.org/10.22354/in.v26i1.991 36 downloads

LATIN AMERICAN RESIDENTS’ SURGICAL EDUCATION AFTER THE PANDEMIC: WHAT STRATEGIES HAVE EMERGED FOR ADAPTING TO THIS NEW ERA?
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Varela, Eduardo

; Castelli, Ignacio

; Szwarcfiter, Vania

; Turner, Lawrence

; Gaete, María Inés

; Belmar, Francisca

; Cortés, Matías

; Jiménez, Gerónimo

; Corvetto, Marcia

; Varas, Julián

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2022, Volume 35 elocation e1708

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO RACIONAL: A pandemia de COVID-19 teve um efeito negativo na educação cirúrgica na América Latina, diminuindo o treinamento cirúrgico dos residentes e a prática clínica supervisionada. OBJETIVOS: Identificar estratégias que foram propostas ou implementadas para adaptar o treinamento cirúrgico e a prática clínica supervisionada às limitações relacionadas ao COVID-19 na América Latina. MÉTODOS: Foi realizada revisão de literatura entre abril-maio de 2021, dividida em duas buscas. O primeiro procurou identificar estratégias de adaptação em América Latina para treinamento cirúrgico e prática clínica supervisionada. A segunda foi realizada como complemento para identificar metodologias propostas no resto do mundo. RESULTADOS: Na primeira busca, foram selecionados 16 dos 715 artigos. Na segunda, foram selecionados 41 dos 1.637 artigos. Estratégias adaptativas propostas na América Latina com foco em videoconferência e simulação. No resto do mundo, foram sugeridas análises críticas remotas de cirurgias gravadas/ao vivo, tele-mentoria intra-cirúrgica e gravação de cirurgia com feedback pós-operatório. CONCLUSÕES: Múltiplas estratégias de adaptação para educação cirúrgica durante a pandemia de COVID-19 foram propostas na América Latina e no resto do mundo. Há uma oportunidade de implementar novas estratégias a longo prazo para treinamento cirúrgico e prática clínica supervisionada, embora mais estudos prospectivos sejam necessários para gerar recomendações baseadas em evidências.

ABSTRACT BACKGROUND: The COVID-19 pandemic has had a negative effect on surgical education in Latin America, decreasing residents’ surgical training and supervised clinical practice. AIMS: This study aimed to identify strategies that have been proposed or implemented to adapt surgical training and supervised clinical practice to COVID-19-related limitations in Latin America. METHOD: A literature review was performed between April and May 2021, divided into two searches. The first one sought to identify adaptation strategies in Latin America for surgical training and supervised clinical practice. The second one was carried out as a complement to identify methodologies proposed in the rest of the world. RESULTS: In the first search, 16 of 715 articles were selected. In the second one, 41 of 1,637 articles were selected. Adaptive strategies proposed in Latin America focused on videoconferencing and simulation. In the rest of the world, remote critical analysis of recorded/live surgeries, intrasurgical tele-mentoring, and surgery recording with postoperative feedback were suggested. CONCLUSIONS: Multiple adaptation strategies for surgical education during the COVID-19 pandemic have been proposed in Latin America and the rest of the world. There is an opportunity to implement new strategies in the long term for surgical training and supervised clinical practice, although more prospective studies are required to generate evidence-based recommendations.

https://doi.org/10.1590/0102-672020220002e1708

Kefir fermented fruit by-products: anti-Alicyclobacillus spp. activity, and antioxidant activity
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MENEZES, Jéssica Lima de

; MIZUTA, Amanda Gouveia

; DUTRA, Tatiane Viana

; FERREIRA, Taiana Varela

; BONIN, Edinéia

; CASTRO, Juliana Cristina

; SCHIPFER, Caroline Wolf Trentini

; SZCZEREPA, Márcia Maria dos Anjos

; LANCHEROS, César Armando Contreras

; PILAU, Eduardo Jorge

; MACHINSKI JUNIOR, Miguel

; MIKCHA, Jane Martha Graton

; ABREU FILHO, Benício Alves de

Food Science and Technology

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2022, Volume 42 elocation e117621

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to investigate the antimicrobial activity of kefir fermented fruit by-products against strains of Alicyclobacillus spp., and determine their chemical characterization and antioxidant activity. According to the results, extracts fermented for a longer period (72 h) showed greater inhibition, and the extract of acerola by-product fermented for 72 h achieved the best results. For all strains, the Minimal Inhibitory Concentration (MIC) was 0.78%, except for A. acidocaldarius subsp. rittmannii, (1.56%). The same applies to the Minimal Bactericidal Concentration (MBC), in which 1.56% of the extract was capable of inactivating A. cycloheptanicus and A. acidocaldarius. In addition, damages to the structure of the microorganisms caused by the extracts were detected by Scanning Electron Microscopy. Metabolite identification through liquid chromatography (UHPLC-Qtof-MS) showed that the fermented extracts had a greater number of compounds compared to the non-fermented ones, such as glucuronic, succinic and glutaric acids. In conclusion, the extracts of fruit by-products showed to have bioactive properties, such as antibacterial potential and antioxidant activity against the Alicyclobacillus strains tested in this study, not to mention the value added by the use of a food by-product.

https://doi.org/10.1590/fst.117621

Espina bífida abierta. Diagnóstico, pronóstico y opciones de corrección intrauterina por cirugía fetal abierta y fetoscópica
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Lara-Ávila,, Leticia

; Martínez-Rodríguez,, Miguel

; Villalobos-Gómez,, Rosa

; Gámez-Varela,, Alma

; Aguilar-Avidales,, Karla

; López-Briones,, Hugo

; Estudillo-Moreno,, Eduardo

; Chavelas-Ochoa,, Felipe

; Cruz-Martínez, Rogelio

Ginecología y obstetricia de México

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2022, Volume 90 Nº 1 Páginas 73 - 83

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract BACKGROUND: Open spina bifida is the leading cause of infant disability; its prevalence is 4 to 5 cases per 10,000 births. OBJECTIVE: To describe the diagnostic methods, prognosis and outcomes of the different fetal surgical techniques reported for intrauterine correction of open spina bifida. METHODOLOGY: PubMed, Embase, Scope, Scielo and Google Scholar were searched for all articles in English and Spanish published between January 1990 and March 2021 with the MeSH: "spina bifida", "fetal surgery", "myelomeningocele", "spina bifida", "fetal surgery", "myelomeningocele". Cases of open spina bifida with intrauterine correction by some fetal surgery technique were chosen. RESULTS: We found 694 articles and selected 15 studies that included cases of intrauterine correction of open spina bifida and two types of fetal surgical access. Compared to the current use of the classical open fetal surgery technique, fetoscopic techniques demonstrate lower risk of hysterotomy dehiscence and fewer cesarean births, although longer operative times and more complications. Minihysterotomy and microneurosurgery techniques have demonstrated fewer complications and lower risk of hysterotomy dehiscence compared to the classic open technique. CONCLUSIONS: There are several variants in the surgical technique for open intrauterine spina bifida correction. The development of a better minimally invasive fetoscopic technique that demonstrates lower maternal and fetal risks and complications while maintaining the neurological benefits of prental repair is a current line of research by several groups.

Resumen ANTECEDENTES: La espina bífida abierta es la principal causa de discapacidad infantil; su prevalencia es de 4 a 5 casos por cada 10,000 nacimientos. OBJETIVO: Describir los métodos diagnósticos, el pronóstico y los desenlaces de las diferentes técnicas de cirugía fetal reportadas para corrección intrauterina de la espina bífida abierta. METODOLOGÍA: Estudio retrospectivo de búsqueda en PubMed, Embase, Scope, Scielo y Google Scholar de todos los artículos en inglés y español publicados entre enero de 1990 y marzo del 2021 con los MeSH: “espina bífida”, “cirugía fetal”, “mielomeningocele", “spina bifida”, “fetal surgery”, “myelomeningocele”. Se eligieron los casos de espina bífida abierta con corrección intrauterina por alguna técnica de cirugía fetal. RESULTADOS: Se encontraron 694 artículos y se seleccionaron 15 estudios que incluyeron casos de corrección intrauterina de espina bífida abierta y dos tipos de acceso quirúrgico fetal. En comparación con el uso actual de la técnica clásica de cirugía fetal abierta, las técnicas fetoscópicas demuestran menor riesgo de dehiscencia de histerotomía y menos nacimientos por cesárea, aunque mayores tiempos quirúrgicos y más complicaciones. Las técnicas de minihisterotomía y microneurocirugía han demostrado menos complicaciones y menor riesgo de dehiscencia de histerotomía en comparación con la técnica clásica abierta. CONCLUSIONES: Existen diversas variantes en la técnica quirúrgica para la corrección intrauterina de espina bífida abierta. El desarrollo de una mejor técnica de mínima invasión fetoscópica que demuestre menores riesgos y complicaciones maternas y fetales manteniendo los beneficios neurológicos de la reparación prental es una línea de investigación actual de varios grupos.

https://doi.org/10.24245/gom.v90i1.5754 490 downloads

Expression analysis of genes encoding rhamnogalacturonan lyase isoenzymes during tomato fruit development and ripening
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Trillo-Hernández, Eduardo Antonio

; Orozco-Avitia, Jesús Antonio

; Ojeda-Contreras, Ángel Javier

; Berumen-Varela, Guillermo

; Ochoa-Jiménez, Verónica Alhelí

; Troncoso-Rojas, Rosalba

; Rivera-Dominguez, Marisela

; Baez-Flores, María Elena

; Tiznado-Hernández, Martín Ernesto

Revista fitotecnia mexicana

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Dez 2021, Volume 44 Nº 4 Páginas 529 - 536

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen El cultivo de tomate genera grandes ganancias para México; sin embargo, la distribución del fruto enfrenta limitaciones debido a pérdidas postcosecha causadas por su rápido deterioro. La reducción en la firmeza del fruto se debe en parte a la degradación de la pectina localizada en la pared celular primaria. Varios frutos como fresa (Fragaria × ananassa), tomate (Solanum lycopersicum L.) y mango (Mangifera indica L.) muestran incremento en la expresión de genes que codifican para la enzima ramnogalacturonano liasa (RGL) durante la maduración. En tomate RGL es codificada por una familia de 13 multigenes, de los cuales tres están activos en fruto. Ramnogalacturonano I (RG-I) es un polisacárido que forma parte de las pectinas de la pared celular y que es degradado por la enzima RGL. En este sentido, el estudio de los cambios en expresión de genes que codifican para RGL durante el desarrollo y maduración del fruto de tomate ayudará a dilucidar la función fisiológica de esta familia de genes. El objetivo del presente estudio fue evaluar el perfil de expresión de los genes Solyc04g076630, Solyc04g076660 y Solyc11g011300 y la producción de etileno durante el desarrollo y maduración del fruto de tomate. El gen Solyc11g011300 mostró un incremento en actividad que correlacionó con el aumento en la producción de etileno del fruto, lo cual sugiere que este gen cumple una función en la pérdida de firmeza del fruto durante maduración. Los altos niveles de expression de los genes Solyc04g076630 y Solyc04g076660 registrados durante el desarrollo del fruto sugieren su participación en la re-ingeniería del polímero RG-I durante las etapas iniciales de desarrollo del fruto.

Summary Tomato cultivation generates great profits for Mexico; however, the distribution of the fruit faces limitations due to the postharvest losses caused by its rapid deterioration. The reduction in fruit firmness is due in part to the degradation of pectin located in the primary cell wall. Several fruits such as strawberry (Fragaria × ananassa), tomato (Solanum lycopersicum L.) and mango (Mangifera indica L.) show an increase in the expression of genes that code for the enzyme rhamnogalacturonan lyase (RGL) during ripening. In tomato RGL is encoded by a family of 13 multigenes, of which three are active in the fruit Rhamnogalacturonan l (RG-l) is a polysaccharide that is part of the pectins of the cell wall and is degraded by the RGL enzyme. Thus, the study of changes of RGL in the expression of genes that code for RGL during the development and ripening of tomato fruit will help to elucidate the physiological function of this family of genes. The objective of the present study was to assess the expression profile of genes Solyc04g076630, Solyc04g076660 and Solyc11g011300 and the ethylene production during the development and ripening of the tomato fruit. The Solyc11g011300 gene showed an increase in activity that correlated with the increase in ethylene production in fruits, suggesting that this gene plays a role in the loss of firmness of the fruit during ripening. The high levels of expression of genes Solyc04g076630 and Solyc04g076660 recorded during fruit development suggest their participation in the re-engineering of the RG-I polymer during the initial stages of fruit development.

https://doi.org/10.35196/rfm.2021.4.529

Eficacia de lutecio-177 DOTATATE/TOC en pacientes con tumores neuroendocrinos bien diferenciados en estado avanzado. Ensayo clínico fase II
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De los Reyes, Amelia

; Llamas-Olier, Augusto

; Martí, Alejandro

; Fierro-Maya, Felipe

; Rojas, Leonardo

; Martínez, María Cristina

; Granados, Carlos Eduardo

; Varela, Humberto

; Calderón, Álvaro

; Barbosa, Nathaly

; Delgado, Nydia

; Rada, Javier

; Cuéllar, Diana Isabel

; Lozano, Alfonso

; Muleth, Yeinnyer

Revista Colombiana de Cancerología

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Mar 2021, Volume 25 Nº 1 Páginas 13 - 24

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Introducción: En 2009, el Instituto Nacional de Cancerología (INC) elaboró el 177Lu-DOTATATE/TOC. El propósito del estudio fue demostrar la eficacia de estos radiopéptidos en el tratamiento paliativo de pacientes con tumores neuroendocrinos (TNE) avanzados inoperables (metastásicos o localmente avanzados) y en progresión. Métodos: Ensayo clínico abierto fase II de un solo brazo en 13 pacientes adultos con TNE grado 1 o 2, con expresión de receptores de somatostatina en lesiones blanco demostrada por captación Krenning 3 o 4 en 99mTc-HYNIC TOC. Los pacientes fueron tratados con 177Lu-DOTATATE o 177Lu-DOTATOC (según disponibilidad) a una actividad acumulativa proyectada de 600-800 mCi dividida en 3-4 dosis cada 6-9 semanas comenzando siempre con una actividad fija de 200 mCi y dosimetría con la primera dosis. El desenlace primario fue la respuesta objetiva calculada 6 y 12 meses después de la última dosis del tratamiento. Resultados: Se incluyeron 13 pacientes (7 mujeres) de 63 ± 11,6 años con TNE avanzado inoperable y en progresión. La actividad final administrada fue de 800 mCi, 600 mCi, 400 mCi y 200 mCi en 4, 7, 1 y 1 pacientes, respectivamente. La tasa de control de enfermedad a 6 y 12 meses fue de 69,2% y 45,5%, respectivamente, logrando únicamente enfermedad estable. Fallecieron 7 pacientes, 2 de ellos en los primeros 6 meses. La mediana de supervivencia global a partir de la última dosis del radiopéptido fue de 15,7 meses. Conclusiones: Se corroboró la eficacia y la seguridad del tratamiento con los radiopéptidos en NETs avanzados.

Abstract Objectives: The National Cancer Institute first elaborated 177Lu-DOTATATE/TOC in 2009. The purpose of this study was to prove the efficacy of these radiopeptides in the palliative treatment of patients with progressive advanced inoperable neuroendocrine tumors (NETs). Methods: A single-phase phase II open clinical trial was conducted in 13 adult patients with grade 1 y 2 NETs, with expression of somatostatin receptors in target lesions proven by Krenning Score 3 or 4 uptake in 99mTc-HYNIC TOC. Patients were treated with 177Lu-DOTATATE or 177Lu-DOTATOC (depending upon availability) at a projected acumulative activitiy of 600-800 mCi divided into 3-4 doses every 6-9 weeks always beginning with a fixed activity of 200 mCi and dosimetry during the first dose. The primary outcome was objective response to therapy. Results: 13 patients (7 women) aged 63 ± 11.6 years with inoperable advanced NETs were included. The final therapeutic administered activity was 800 mCi, 600 mCi, 400 mCi and 200 mCi in 4, 7, 1 and 1 patients, respectively. The disease control rate at 6 and 12 months was 69.2% and 45.5%, respectively, only obtaining stable disease. Six patients died, 2 of them in the first 6 months. Median overall survival was 15.7 months from the last treatment dose. Conclusions: The efficacy of the treatment with 177Lu-DOTATATE or 177Lu-DOTATOC radiopeptides elaborated in-house was confirmed, becoming a management alternative for patients with advanced NETs.

https://doi.org/10.35509/01239015.132 244 downloads

10.

Evaluación financiera de producción de agave y mezcal: caso de estudio Caltepec, Puebla
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Fonseca Varela, Mariana

; Chalita Tovar, Luis Eduardo

Revista mexicana de ciencias agrícolas

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Mar 2021, Volume 12 Nº 2 Páginas 263 - 273

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract In recent years the production of agave distillates in Mexico, including mezcal, has become increasingly important. In the period 2013-2019, its value has increased to an average annual rate of 19.76%. Such behaviour has been driven by product prices and increasing domestic and international demand, compared to the latter concept from 2017 to 2018 mezcal exports grew at a rate of 34.40%. This has led to more and more productive units linking to the agave value chain, as has been the case of the municipality of Caltepec, Puebla, whose population is in poverty and lives on agriculture. In this sense, it is necessary to analyze the opportunities that agave and mezcal production could generate, to provide productive opportunities that seek to improve the municipal economy. Based on the above, a financial assessment was developed from 2020 with a planning period of eight and 15 years from the start-up of the project. Research findings suggest that both types of business opportunities are financially feasible, because have a net present value of $34 074.09 and $1 911 792.96, respectively. They can therefore serve as potential alternatives to improving the wellness of different productive units in the region, thereby helping to alleviate local poverty.

Resumen En los últimos años la producción de destilados de agave en México, dentro de ellos el mezcal, se ha vuelto cada vez más importante. En el periodo 2013-2019, su valor ha aumentado a una tasa promedio anual de 19.76%. Tal comportamiento ha sido impulsado por los precios del producto y la creciente demanda nacional e internacional, respecto a este último concepto de 2017 a 2018 las exportaciones de mezcal crecieron a una tasa de 34.4%. Lo anterior, ha llevado a que cada vez más unidades productivas se vinculen a la cadena de valor del agave, como ha sido el caso del municipio de Caltepec, Puebla, cuya población se encuentra en pobreza y vive de la agricultura. En este sentido, es necesario analizar las oportunidades que pudiera generar la producción de agave y mezcal, para proveer oportunidades productivas que busquen mejorar la economía municipal. Con base en lo anterior, se elaboró una evaluación financiera a partir del año 2020 con un periodo de planeación de ocho y 15 años a partir de la puesta en marcha del proyecto. Los hallazgos de la investigación sugieren que ambos tipos de oportunidades de negocio son factibles financieramente, al obtener un valor actual neto de $34 074.09 y $1 911 792.96, respectivamente. Por lo que pueden servir como alternativas potenciales a mejorar el bienestar de distintas unidades productivas de la región, con ello coadyubando a mitigar la pobreza local.

https://doi.org/10.29312/remexca.v12i2.2583 99 downloads

11.

Bleeding complication after surgical removal of impacted teeth in a patient with undiagnosed clotting disorder
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RODRIGUES NETO, Hugo Leite

; COSTA, Tony Eduardo

; SILVARES, Marcelo Galindo

; PARENTE, Eduardo Varela

; MARLIÈRE, Daniel Amaral Alves

RGO - Revista Gaúcha de Odontologia

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2021, Volume 69 elocation e20210038

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Relatar um caso de episódios de sangramento após remoção de dentes inclusos em paciente com distúrbio de coagulação não diagnosticado, descrevendo uma sequência de condutas para hemostasia até o diagnóstico apropriado e resolução efetiva. Paciente do gênero masculino, 16 anos, com indicação de remoção de 8 dentes inclusos. Após a cirurgia, houve episódios de sangramento, sendo necessária sua internação para integridade das funções orgânicas básicas, realização de exames laboratoriais, controle hemodinâmico e tentativa de obtenção de hemostasia por meio de antifibrinolíticos e hemoderivados. Após 24 horas de internação, 11% do fator IX de coagulação foi verificado na corrente sanguínea por meio de exame específico, sendo o paciente diagnosticado com Hemofilia B de caráter leve. A partir do diagnóstico, infusões do fator deficiente foram realizadas para resolutividade adequada e recuperação do paciente. As condutas realizadas foram eficientes para manutenção dos sinais vitais até a hemostasia obtida após diagnóstico adequado. No entanto, as condutas preventivas devem ser aplicadas em pacientes hemofílicos no pré- ou trans-operatórios, evitando circunstâncias que podem comprometer o estado de saúde do paciente.

ABSTRACT To report one case of bleeding episodes after impacted teeth extractions had been performed in a patient with undiagnosed clotting disorder, describing a sequence of approaches for hemostasis up to the appropriated diagnosis and effective resolution. A male 16-year old patient with surgical indication to remove eight impacted teeth. After the surgery, there were bleeding episodes, being needed for hospital admission to keep on his physiological functions, blood pressure and heartbeat frequency regularly, to carry out laboratory blood tests, and to achieve hemostasis by using antifibrinolytics and blood products. After 24 hours, 11% of IX clotting factor was verified into bloodstream by specific blood test, being diagnosed with mild Hemophilia B. From the diagnosis, infusions of IX clotting factor were performed to the adequate resolution and recovery of the patient. The clinical conducts were efficient to keep on stable vital signs and achieving appropriate diagnosis. However, preventive behaviors should be applied in hemophilic patients in pre- or intra-operative, avoiding circumstances that can compromise health condition of the patient.

https://doi.org/10.1590/1981-863720200003820190152 1 downloads

12.

Cuidados especiales de recién nacidos y lactantes pequeños que requieren hospitalización por infecciones respiratorias
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Pírez, Catalina

; Peluffo, Gabriel

; Giachetto, Gustavo

; Menchaca, Amanda

; Pérez, Walter

; Machado, Karina

; Cristoforone, Natalia

; Alamilla, Mariela

; Acosta, Victoria

; Bruneto, Mabel

; Assandri, María

; Toscano, Bárbara

; Telechea, Héctor

; Rompani, Eduardo

; Morosini, Fabiana

; Taboada, Rosario

; Notejane, Martín

; Pacaluk, Martha

; Pujadas, Mónica

; Cladera, Pedro

; Algorta, Gabriela

; Varela, Adriana

Archivos de Pediatría del Uruguay

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Dez 2020, Volume 91 Supl. 1 Páginas 52 - 56

Resumo: Es | Texto: Es | PDF: Es

https://doi.org/10.31134/ap.91.s1.9 1054 downloads

13.

Oxigenoterapia
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Pírez, Catalina

; Peluffo, Gabriel

; Giachetto, Gustavo

; Menchaca, Amanda

; Pérez, Walter

; Machado, Karina

; Cristoforone, Natalia

; Alamilla, Mariela

; Acosta, Victoria

; Bruneto, Mabel

; Assandri, María

; Toscano, Bárbara

; Telechea, Héctor

; Rompani, Eduardo

; Morosini, Fabiana

; Taboada, Rosario

; Notejane, Martín

; Pacaluk, Martha

; Pujadas, Mónica

; Cladera, Pedro

; Algorta, Gabriela

; Varela, Adriana

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Dez 2020, Volume 91 Supl. 1 Páginas 26 - 28

Resumo: Es | Texto: Es | PDF: Es

https://doi.org/10.31134/ap.91.s1.1 21588 downloads

14.

Fisioterapia respiratoria en el tratamiento de niños con infecciones respiratorias agudas bajas
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Pírez, Catalina

; Peluffo, Gabriel

; Giachetto, Gustavo

; Menchaca, Amanda

; Pérez, Walter

; Machado, Karina

; Cristoforone, Natalia

; Alamilla, Mariela

; Acosta, Victoria

; Bruneto, Mabel

; Assandri, María

; Toscano, Bárbara

; Telechea, Héctor

; Rompani, Eduardo

; Morosini, Fabiana

; Taboada, Rosario

; Notejane, Martín

; Pacaluk, Martha

; Pujadas, Mónica

; Cladera, Pedro

; Algorta, Gabriela

; Varela, Adriana

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Dez 2020, Volume 91 Supl. 1 Páginas 38 - 39

Resumo: Es | Texto: Es | PDF: Es

https://doi.org/10.31134/ap.91.s1.6 2693 downloads

15.

Cuidados de enfermería en pacientes con oxígeno de alto flujo y ventilación no invasiva
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Pírez, Catalina

; Peluffo, Gabriel

; Giachetto, Gustavo

; Menchaca, Amanda

; Pérez, Walter

; Machado, Karina

; Cristoforone, Natalia

; Alamilla, Mariela

; Acosta, Victoria

; Bruneto, Mabel

; Assandri, María

; Toscano, Bárbara

; Telechea, Héctor

; Rompani, Eduardo

; Morosini, Fabiana

; Taboada, Rosario

; Notejane, Martín

; Pacaluk, Martha

; Pujadas, Mónica

; Cladera, Pedro

; Algorta, Gabriela

; Varela, Adriana

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Dez 2020, Volume 91 Supl. 1 Páginas 48 - 51

Resumo: Es | Texto: Es | PDF: Es

https://doi.org/10.31134/ap.91.s1.8 5612 downloads

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