ABSTRACT Objective: To measure the costs of preventive and therapeutic protocols of Photobiomodulation (PBM) for oral mucositis (OM) and their budgetary impact on Brazil’s Ministry of Health (BMH). Material and Methods: A partial economic analysis was performed to estimate the costs using a bottom-up approach from a social perspective. Monetary values were assigned in Brazilian reais (BRL). The costs of the preventive protocol were calculated for five, 30, and 33 consecutive PBM sessions, depending on the antineoplastic treatment instituted. The costs of the therapeutic protocol were calculated for 5 or 10 sessions. The annual financial and budgetary impact was calculated considering the groups of oncologic patients with a higher risk of development of OM, such as those with head and neck and hematological cancer and pediatric patients. Results: The cost of a PBM session was estimated at BRL 23.75. The financial impact of providing one preventive protocol per year for all oncologic patients would be BRL 14,282,680.00, 0.030% of the estimated budget for hospital and outpatient care of the BMH in 2022. The financial and budgetary impacts of providing one treatment for OM for all patients in one year would be BRL 2,225,630.31 (0.005%, most optimistic scenario) and BRL 4,451,355.63 (0.009%, most pessimistic scenario). Conclusion: The budgetary impact of implementing PBM protocols in the Brazilian Healthcare System is small, even in a pessimistic scenario. Objective (PBM (OM Brazils Brazil s BMH. . (BMH) Methods bottomup bottom up perspective BRL. (BRL) five 30 3 sessions instituted 1 Results 2375 23 75 23.75 1428268000 14 282 680 00 14,282,680.00 0030 0 030 0.030 2022 222563031 2 225 630 31 2,225,630.3 0.005%, 0005 005 (0.005% scenario 445135563 4 451 355 63 4,451,355.6 0.009%, 0009 009 (0.009% Conclusion small (BMH (BRL 237 7 23.7 142826800 28 68 14,282,680.0 003 03 0.03 202 22256303 22 2,225,630. 0.005% 000 (0.005 44513556 45 35 6 4,451,355. 0.009% (0.009 23. 14282680 14,282,680. 0.0 20 2225630 2,225,630 0.005 (0.00 4451355 4,451,355 0.009 1428268 14,282,680 0. 222563 2,225,63 0.00 (0.0 445135 4,451,35 142826 14,282,68 22256 2,225,6 (0. 44513 4,451,3 14282 14,282,6 2225 2,225, (0 4451 4,451, 1428 14,282, 222 2,225 ( 445 4,451 142 14,282 2,22 44 4,45 14,28 2,2 4,4 14,2 2, 4, 14,

Abstract The aim of this study was to investigate the DNA methylation profile in genes encoding catalase (CAT) and superoxide dismutase (SOD3) enzymes, which are involved in oxidative stress mechanisms, and in genes encoding pro-inflammatory cytokines interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-α) in the oral mucosa of oncopediatric patients treated with methotrexate (MTX®). This was a cross-sectional observational study and the population comprised healthy dental patients (n = 21) and those with hematological malignancies (n = 64) aged between 5 and 19 years. Oral conditions were evaluated using the Oral Assessment Guide and participants were divided into 4 groups: 1- healthy individuals; 2- oncopediatric patients without mucositis; 3- oncopediatric patients with mucositis; 4- oncopediatric patients who had recovered from mucositis. Methylation of DNA from oral mucosal cells was evaluated using the Methylation-Specific PCR technique (MSP). For CAT, the partially methylated profile was the most frequent and for SOD3 and IL6, the hypermethylated profile was the most frequent, with no differences between groups. For TNF-α, the hypomethylated profile was more frequent in the group of patients who had recovered from mucositis. It was concluded that the methylation profiles of CAT, SOD3, and IL6 are common profiles for oral cells of children and adolescents and have no association with oral mucositis or exposure to chemotherapy with MTX®. Hypomethylation of TNF-α is associated with oral mucosal recovery in oncopediatric patients who developed oral mucositis during chemotherapy. CAT (CAT SOD (SOD3 enzymes mechanisms proinflammatory pro inflammatory interleukin6 interleukin 6 interleukin- IL (IL6 factoralpha factor alpha TNFα TNF α (TNF-α MTX MTX® . (MTX®) crosssectional cross sectional n 21 64 1 years groups individuals 2 3 MethylationSpecific Specific MSP. MSP (MSP) TNFα, α, (SOD (IL (MTX® (MSP (MTX

ABSTRACT Objective To identify factors associated with hospitalization in the intensive care unit in children and adolescents with COVID-19. Methods This was a retrospective cohort study using secondary data of hospitalized children and adolescents (zero to 18 years old) with COVID-19 reported in Paraíba from April 2020 to July 2021, totaling 486 records. Descriptive analysis, logistic regression and multilevel regression were performed, utilizing a significance level of 5%. Results According to logistic regression without hierarchical levels, there was an increased chance of admission to the intensive care unit for male patients (OR = 1.98; 95%CI 1.18 - 3.32), patients with respiratory distress (OR = 2.43; 95%CI 1.29 - 4.56), patients with dyspnea (OR = 3.57; 95%CI 1.77 - 7.18) and patients living in large cities (OR = 2.70; 95%CI 1.07 - 6.77). The likelihood of requiring intensive care was observed to decrease with increasing age (OR = 0.94; 95%CI = 0.90 - 0.97), the presence of cough (OR = 0.32; 95%CI 0.18 - 0.59) or fever (OR = 0.42; 95%CI 0.23 - 0.74) and increasing Gini index (OR = 0.003; 95%CI 0.000 - 0.243). According to the multilevel analysis, the odds of admission to the intensive care unit increased in male patients (OR = 1.70; 95%CI = 1.68-1.71) and with increasing population size of the municipality per 100,000 inhabitants (OR = 1.01; 95%CI 1.01-1.03); additionally, the odds of admission to the intensive care unit decreased for mixed-race versus non-brown-skinned patients (OR = 0.981; 95%CI 0.97 - 0.99) and increasing Gini index (OR = 0.02; 95%CI 0.02 - 0.02). Conclusion The effects of patient characteristics and social context on the need for intensive care in children and adolescents with SARS-CoV-2 infection were better estimated with the inclusion of a multilevel regression model. COVID19. COVID19 COVID 19. 19 zero 1 old COVID-1 202 2021 48 records analysis performed 5 5% levels OR 1.98 198 98 95CI CI 95 118 1.1 3.32, 332 3.32 , 3 32 3.32) 2.43 243 2 43 129 29 1.2 4.56, 456 4.56 4 56 4.56) 3.57 357 57 177 77 1.7 7.18 718 7 2.70 270 70 107 07 1.0 6.77. 677 6.77 . 6 6.77) 0.94 094 0 94 090 90 0.9 0.97, 097 97 0.97) 0.32 032 018 0.1 0.59 059 59 0.42 042 42 023 23 0.2 0.74 074 74 0.003 0003 003 0000 000 0.00 0.243. 0243 0.243 0.243) 1.70 170 1.681.71 168171 1.68 1.71 68 71 1.68-1.71 100000 100 100,00 1.01 101 01 1.011.03 101103 1.03 03 1.01-1.03) additionally mixedrace mixed race nonbrownskinned non brown skinned 0.981 0981 981 0.99 099 99 002 02 0.0 0.02. 0.02) SARSCoV2 SARSCoV SARS CoV SARS-CoV- model COVID1 COVID- 20 1.9 9 11 1. 33 3.3 2.4 24 12 45 4.5 3.5 35 17 7.1 2.7 27 10 67 6.7 09 0. 0.3 0.5 05 0.4 04 0.7 00 024 0.24 681 1.681.7 16817 168 1.6 171 1.68-1.7 10000 100,0 011 1.011.0 10110 103 1.01-1.03 0.98 098 SARS-CoV 3. 2. 4. 7. 6. 1.681. 1681 16 1.68-1. 1000 100, 1.011. 1011 1.01-1.0 1.681 1.68-1 1.011 1.01-1. 1.68- 1.01-1 1.01-

RESUMO Objetivo Identificar fatores associados ao internamento na unidade de terapia intensiva de crianças e adolescentes com COVID-19. Método Estudo de coorte retrospectiva, com dados secundários, de crianças e adolescentes hospitalizados (zero a 18 anos), notificados com COVID-19 na Paraíba, de abril de 2020 a julho de 2021, totalizando 486 registros. Foram realizadas análise descritiva, regressão logística e regressão multinível, considerando o nível de significância de 5%. Resultados Na regressão logística sem níveis hierárquicos, ocorreu aumento da chance de internamento na unidade de terapia intensiva em pacientes do sexo masculino (RC = 1,98; IC95% 1,18 - 3,32), com desconforto respiratório (RC = 2,43; IC95% 1,29 - 4,56), dispneia (RC = 3,57; IC95% 1,77 - 7,18) e residentes em cidades com grande porte populacional (RC = 2,70; IC95% 1,07 - 6,77). Foi observada diminuição da chance de cuidados intensivos com aumento da idade em anos (RC = 0,94; IC95%=0,90 - 0,97), presença de tosse (RC = 0,32; IC95% 0,18 - 0,59), febre (RC = 0,42; IC95% 0,23 - 0,74) e aumento no Índice de Gini (RC = 0,003; IC95% 0,000 - 0,243). Na análise multinível, a chance de internamento na unidade de terapia intensiva aumentou no sexo masculino (RC = 1,70; IC95%=1,68-1,71) e por conta do aumento no porte populacional do município a cada 100 mil habitantes (RC = 1,01; IC95% 1,01 - 1,03); a chance de internamento na unidade de terapia intensiva diminuiu em pacientes pardos versus não pardos (RC = 0,981; IC95% 0,97 - 0,99) e por conta do aumento a cada pontuação do Índice de Gini (RC = 0,02; IC95% 0,02 - 0,02). Conclusão Os efeitos das condições próprias do paciente e do contexto social na necessidade de cuidados intensivos em crianças e adolescentes com infecção pelo SARS-CoV-2 são mais bem estimados com a inclusão de um modelo de regressão multinível nas análises. COVID19. COVID19 COVID 19. 19 retrospectiva secundários zero 1 anos, , anos) COVID-1 Paraíba 202 2021 48 registros descritiva 5 5% hierárquicos RC 1,98 198 98 IC95 IC 118 1,1 3,32, 332 3,32 3 32 3,32) 2,43 243 2 43 129 29 1,2 4,56, 456 4,56 4 56 4,56) 3,57 357 57 177 77 1,7 7,18 718 7 2,70 270 70 107 07 1,0 6,77. 677 6,77 . 6 6,77) 0,94 094 0 94 IC95090 90 IC95%=0,9 0,97, 097 97 0,97) 0,32 032 018 0,1 0,59, 059 0,59 59 0,59) 0,42 042 42 023 23 0,2 0,74 074 74 0,003 0003 003 0000 000 0,00 0,243. 0243 0,243 0,243) 1,70 170 IC95%=1,681,71 IC95168171 IC95%=1,68 1,71 68 71 IC95%=1,68-1,71 10 101 01 1,03 103 03 1,03) 0,981 0981 981 0,9 0,99 099 99 002 02 0,0 0,02. 0,02) SARSCoV2 SARSCoV SARS CoV SARS-CoV- análises COVID1 COVID- 20 1,9 9 IC9 11 1, 33 3,3 2,4 24 12 45 4,5 3,5 35 17 7,1 2,7 27 67 6,7 09 IC9509 IC95%=0, 0,3 0, 05 0,5 0,4 04 0,7 00 024 0,24 681 IC95%=1,681,7 IC9516817 IC95168 IC95%=1,6 171 IC95%=1,68-1,7 0,98 098 SARS-CoV 3, 2, 4, 7, 6, IC950 IC95%=0 IC95%=1,681, IC951681 IC9516 IC95%=1, IC95%=1,68-1, IC95%= IC95%=1,681 IC951 IC95%=1 IC95%=1,68-1 IC95%=1,68-

ABSTRACT Objective: To report nine cases of pediatric patients with Acute Lymphoid Leukemia (ALL) or Acute Myeloid Leukemia who developed severe oral mucositis (SOM) at the first week of chemotherapy. Material and Methods: The cases were selected from a sample of 105 children followed for 10 consecutive weeks. Hematological and personal data were obtained from the patient's medical records. The oral cavity was examined weekly using the modified Oral Assessment Guide. Results: More of the patients were male (55.6%), had black/brown skin (55.6%), with ALL (66.7%), and the mean age was 5.55. Two patients had values below normal for leukocytes, platelets, and creatinine over the follow-up. However, all patients showed changes in the normality of hematological data in most weeks. The most used chemotherapeutic agents were aracytin, etoposide, and methotrexate, known for their high stomatotoxic potential. Patients had 2 to 6 (mean of 4) episodes of SOM and 4 to 7 (mean of 5.5) episodes of OM. One patient at week 7, one patient at week 5, and one patient at weeks 2 and 10 did not have OM. Saliva (84 times) and lips (44 times) were the most affected items. Conclusion: The patients showed oscillations in the severity of oral mucositis and hematological parameters over the follow-up. All patients were exposed to stomatotoxic drugs during the initial phase of cancer treatment. Objective (ALL (SOM chemotherapy Methods 1 s records Guide Results 55.6%, 556 55.6% , 55 (55.6%) blackbrown black brown 66.7%, 667 66.7% 66 (66.7%) 555 5 5.55 leukocytes platelets followup. followup follow up. up follow-up However aracytin etoposide methotrexate potential 5.5 OM 84 (8 times 44 (4 items Conclusion treatment 55.6 (55.6% 66.7 (66.7% 5. 8 ( 55. (55.6 66. (66.7 (55. (66. (55 (66 (5 (6

Abstract Oral mucositis (OM) is a painful inflammatory oral condition that affects children who undergo chemotherapy. Oxidative stress is a known OM mediator and pro-inflammatory cytokines contribute to the amplification of the immune response. Objective: To investigate the possible associations of rs4880 (superoxide dismutase 2, SOD2 47 C/T), rs7943316 (catalase, CAT −21 A/T), rs1800629 (tumor necrosis factor α, TNF- α −308 G/A), and rs1800795 (interleukin 6, IL-6 −174 G/C) polymorphisms with chemo-induced OM occurrence and severity in oncopediatric patients. Methodology: We conducted a single-center, observational cross-sectional study with sample collection of oral epithelial cells from 95 children and adolescents with hematological cancers who underwent chemotherapy, followed by genomic DNA extraction. Single-nucleotide polymorphisms (SNPs) were assessed with PCR-RFLP (Polymerase Chain Reaction-Restriction Fragment Length Polymorphism). Demographic data and information concerning OM occurrence were obtained from dental charts of the multidisciplinary oral care team. Information on OM severity was obtained from appropriately-filled Oral Assessment Guide records. Descriptive and inferential statistics were conducted with Student's T test, chi-squared test, and Fisher's exact test, with p≤0.05. Results: The mean age was 10 years-old and most patients were male individuals (57.89%). Female sex was considered a protective factor for OM occurrence (OR=4.83; CI=[1.14; 16.57]). The AA genotype for CAT was the most frequent amongst individuals with severe OM (p=0.04). The GA genotype for TNF- α was the most frequent amongst individuals without severe OM (p=0.03). For SOD2 and IL-6 , the most frequent genotypes were CT and GG respectively for all groups (p>0.05). Conclusion: The AA genotype for CAT −21 A/T was a tendency among the group with severe OM. Data on TNF- α −308 G/A were inconclusive. No associations were detected for SOD2 47 C/T and IL-6 −174 G/C polymorphisms in oncopediatric patients with chemo-induced oral mucositis.

Abstract Objective: To describe the impact of the COVID-19 pandemic on dental care provided to pediatric cancer patients assisted in a referral hospital. Material and Methods: This is an observational, retrospective study based on secondary data extracted from worksheets of dental procedures for patients aged between 0 and 19 years assisted in the pediatric oncology sector of a hospital in João Pessoa, PB, Brazil. Dental procedures performed by the interdisciplinary team of researchers from August 2018 to February 2020 (19 months prior to the pandemic) and from April 2020 to October 2021 (19 months during the pandemic) were totaled and compared. A descriptive analysis of the data was performed. Results: There was a reduction of 80.2% in dental interventions implemented in the sector during the pandemic, with the number of procedures decreasing from 6,210 (the period before the pandemic) to 1,229 (during the pandemic). Most procedures in both periods were performed for patients assisted in beds, for whom there was a reduction of care provided for 81.2% from 5,275 to 994 procedures. Dental procedures in the outpatient clinic decreased by 74.9%, from 935 to 235. Conclusion: The COVID-19 pandemic negatively impacted dental care provided to pediatric oncology patients by restricting dental procedures to emergency demands, compromising performance prevention and health promotion actions.

Resumo O presente estudo investigou a relação entre cinco polimorfismos genéticos e o desenvolvimento de mucosite oral em pacientes pediátricos recebendo quimioterapia com metrotexato. O estudo longitudinal foi conduzido com 64 pacientes e a mucosite oral avaliada pelo Oral Assessment Guide modificado, que tem como objetivo diagnosticar e classificar a mucosite oral. Células epiteliais bucais foram obtidas por bochecho e o DNA foi extraído. Os polimorfismos MTHFR (rs1801133), DNMT3B (rs2424913), ABCC2 (rs717620), ABCG2 (rs2231137) e ABCG2 (rs2231142), foram analisados pela técnica de PCR-RFLP. Dados demográficos, hematológicos e bioquímicos foram coletados a partir de registros médicos. Análise estatística foi realizada utilizando o software SPSS adotando um valor de p=0,05. Observou-se que, o sexo masculino foi predominante (56,2%), e a idade média foi de 10,8 anos (± 4.9). A mucosite oral acometeu 65,6% dos pacientes, dos quais, 61,9% desenvolveram a forma grave da doença. Para o gene ABCG2 (rs2231142), o alelo raro A e o genótipo CA foram mais frequentes em indivíduos com mucosite (p= 0.02; RR = 0.60; CI = 0.387 - 0.813). A gravidade da doença foi observada principalmente em pacientes mais jovens (mediana = 9 anos; p=0.02). Além disso, os pacientes com mucosite oral grave apresentaram menor contagem de leucócitos (mediana = 2150 mm3) em comparação aos pacientes com a forma leve/moderada (mediana = 4200 mm3; p=0.03). Pacientes do sexo feminino e aumento a cada 10.000 plaquetas foram fatores de proteção contra o aparecimento de mucosite oral (p=0.02). Concluiu-se que a presença do polimorfismo rs2231142 aumenta o risco de o paciente desenvolver a mucosite oral, bem como pacientes mais jovens e menor contagem de leucócitos contribui com a severidade.

Abstract The study investigated the relationship between genetic polymorphisms and the development of oral mucositis in pediatric patients undergoing chemotherapy involving methotrexate. A longitudinal study was conducted with 64 patients, and oral mucositis was evaluated by the modified Oral Assessment Guide, which aims to diagnose and classify oral mucositis. Epithelial cells were obtained by mouthwash and DNA was extracted. The polymorphisms MTHFR (rs1801133), DNMT3B (rs2424913), ABCC2 (rs717620), ABCG2 (rs2231137) and ABCG2 (rs2231142) were analyzed by PCR-RFLP method. Demographic, hematological and biochemical data were collected from medical records. Statistical analysis was performed using the SPSS software adopting a p-value of 0.05. Male sex predominated (56.2%), and the mean age was 10.8 years (± 4.9). Oral mucositis affected 65.6% of the patients, of which 61.9% developed the severe form of the disease. For the ABCG2 gene (rs2231142), the rare A allele and CA genotype were more frequent in individuals with mucositis (p= 0.02; RR = 0.60; CI = 0.387 - 0.813). The severity of the disease was mainly observed in younger patients (median = 9 years; p=0.02). Patients with severe oral mucositis presented lower leukocytes count (median = 2.150 mm3) compared to patients with the mild/moderate form (median = 4.200 mm3; p=0.03). Female patients and each 10,000-platelet increase were protective factors against the onset of oral mucositis (p=0.02). It is concluded that rs2231142 polymorphism increases the likelihood of oral mucositis and younger patients and patients with low leukocytes counts are more likely to develop severe form.

Abstract Objective: To analyze the distribution of childhood cancer in Brazil and the time between the diagnosis and the start of treatment, according to hospital-based cancer registries (2010-2016). Material and Methods: This was an observational descriptive study using secondary data (36,187 records) from hospital databases of the National Cancer Institute (INCA) and the Onco-center Foundation of São Paulo (FOSP). Epidemiological data were obtained, and compliance with Federal Law 12,732/12 was verified, which establishes a maximum period of 60 days to start cancer therapy after the diagnosis. Absolute and percent frequencies, central tendency and dispersion measures, and the coefficient of prevalence of childhood cancer were calculated. Results: The mean age of the pediatric patients was 9.3 years (± 6.2); 54.1% (n=19,586) of them were males; 32.0% (n=11,440) were aged 0 to 4 years; and 43.4% (n=11,338) had a self-reported mixed-race skin color. The Southeast region of Brazil accounted for 40.2% (n=14,564) of the cases, of which 63.0% (n=9,178) corresponded to solid neoplasms, as opposed to the North region, where hematological neoplasms prevailed (53.9%, n=1,535). Most registered patients aged 0 to 19 years were treated in 60 days or less (77%, n=27,929). However, for 24.0% (n = 2,207) of adolescents (15 to 19 years) this time was more than 60 days after the diagnosis. Conclusion: The characteristics related to childhood cancer varied across the Brazilian geographic regions, and most patients were properly treated within the time enforced by law.

ABSTRACT Objective: To characterize the access to primary dental care and the work process of Oral Health Teams (OHTs), nationwide and by geographic region, based on data from the 3rd phase of the PMAQ-AB (the Program for Improving Access and Quality of Primary Care). Material and Methods: This was a cross-sectional study using data from the external assessments of the PMAQ-AB regarding the variables access to dental care and the work process of OHTs. The data were analyzed descriptively. Results: A significant number of healthcare users (41.2%) reported an average waiting time of 10 days to schedule dental appointments at the primary care facility (PCF). In the Northeast region, a greater number of users (48.4%) had access to dental care, with a waiting time of 7 days, whereas a smaller number of users in the Southeast region could schedule an appointment with the dentist (33.9%) and experienced a longer waiting time (17 days). Most OHTs worked in Primary Care Teams (PCTs) (85.1%), received support from Specialized Dental Care Centers (70.9%), worked with scheduled appointments and/or spontaneous demands (98.0%), listened to the users’ complaints during user embracement sessions (99.0%), and scheduled the first appointment at the dental office (51.9%). Conclusion: In Brazil, 41.2% of the healthcare users had access to dental care and experienced a waiting time ranging from 7 to 17 days, depending on the geographic region. While the OHTs developed primary oral care actions, further initiatives to ensure the expansion of access to dental care are needed.

Resumo Avaliou-se o efeito dos vernizes CPP-ACP/NaF e xilitol/NaF na redução da erosão e progressão da erosão. Quarenta blocos de esmalte foram divididos em quatro grupos (n=10): G1=verniz CPP-ACP/NaF (verniz MITM); G2=verniz xilitol/NaF (Profluorid®); G3=verniz NaF (Duraphat®, controle positivo) e G4=água desionizada (MilliQ®, controle negativo). As amostras foram imersas em refrigerante Sprite ZeroTM (pH 2.58, 4x/dia, 3 dias), entre imersões, os espécimes ficaram em saliva artificial. Após 3 dias de erosão, a área erodida foi dividida em duas (metade recebeu uma camada adicional de verniz, enquanto a outra metade repetiu o mesmo ciclo de erosão de 3 dias). A técnica de perfilometria 3D de não contato foi utilizada para determinar a perda de estrutura dentária (PED) e rugosidade superficial (RS). Microscopia eletrônica de varredura (MEV) e imagens em 3D foram utilizadas para avaliar a topografia das amostras. Testes de Mann-Whitney, One-way ANOVA e Tukey foram utilizados (nível de significância de 0,05%). Imagens do MEV e 3D foram avaliadas descritivamente. Após 3 ou 6 dias de erosão, todos os vernizes testados foram melhores que G4 (p<0,05) para PED e RS. Além disso, o G1 apresentou menores valores de PED do que o G3 (p<0,05) após 3 dias de erosão. Observando as imagens em MEV e 3D, todos os grupos apresentaram porosidade, irregularidades e depressões no esmalte superficial após 3 e 6 dias de erosão, sendo mais pronunciados no G4. Uma aplicação tópica de vernizes fluoretados foi eficaz na redução da rugosidade e PED do esmalte após desafios de erosão. Além disso, o grupo CPP-ACP/NaF teve melhor desempenho na redução da PED quando comparado ao verniz de NaF e a água, após 3 dias de erosão.

Abstract Evaluated the effect of CPP-ACP/NaF and xylitol/NaF varnishes in reduce erosion and progression of erosion. Forty enamel blocks were divided into four groups (n=10): G1=CPP-ACP/NaF varnish (MI varnishTM); G2=xylitol/NaF varnish (Profluorid®); G3=NaF varnish (Duraphat®, positive control) and G4=deionized water (MilliQ®, negative control). Samples were immersed in Sprite ZeroTM (pH 2.58, 4x/day, 3 days), in between immersions, the specimens stayed in artificial saliva. After 3 days of erosion, the eroded area was divided in two (half of one received an additional varnish layer while the other half repeated the same 3-day erosion cycle). The 3D, non-contact profilometry technique was used to determinate tooth structure loss (TSL) and surface roughness (SR). Scanning electron microscopy (SEM) and 3D images were utilized to evaluate the topography of the samples. Mann-Whitney, one-way ANOVA and Tukey tests were used (significance level of 0.05%). SEM and 3D images were descriptively evaluated. After 3 or 6 days of erosion, all tested varnishes were better than G4 (p<0.05) for TSL and SR. In addition, G1 had lower values for TSL than G3 (p<0.05) after 3 days of erosion. Under SEM and 3D images observation, all groups presented porosity, irregularities and depressions on the surface enamel after 3 and 6 days of erosion, more pronounced in G4. An application of topical NaF varnishes was effective in reducing TSL and enamel roughness after erosion challenges, being the CCP-ACP/NaF varnish more effective than NaF varnish and water after 3 days of erosion.

RESUMO Objetivou-se identificar os fatores associados à satisfação dos usuários com a oferta de cuidado em saúde bucal na Paraíba a partir de dados do 2º ciclo de avaliação externa do Programa Nacional de Melhoria do Acesso e da Qualidade da Atenção Básica (PMAQ-AB). As respostas dos usuários que passaram por consulta odontológica com a Equipe de Saúde Bucal (ESB) e possuíam dados completos foram analisadas por meio de regressão logística. Em relação à variável dependente ‘Satisfação do usuário’, 87% dos usuários (n=2.047), afirmaram estar satisfeitos com o cuidado que recebem da ESB. A insatisfação foi influenciada pelo fato de o usuário nunca ou quase nunca ser orientado sobre os cuidados com a sua saúde bucal (OR=4,27); o tempo da consulta ser insuficiente (OR=3,38); os profissionais não fazerem anotações no prontuário ou ficha (OR=1,97); a ESB não atender no turno da tarde (OR=1,66); o horário do atendimento odontológico não satisfazer às necessidades dos usuários (OR=2,86); e a ESB não procurar o usuário quando este interrompe o tratamento ou não comparece à consulta odontológica para saber o que aconteceu e retomar o atendimento (OR=1,59). Conclui-se ser expressivo o percentual de usuários satisfeitos com a atenção em saúde bucal na Paraíba, estando os fatores que influenciam a satisfação relacionados principalmente ao atendimento das necessidades dos usuários e ao processo de trabalho da ESB.

ABSTRACT The objective of this study was to identify the factors associated with the user’s satisfaction about the provision of oral health care in the State of Paraíba. The research based on data regarding the 2nd cycle of the external evaluation of the National Program for Improving Access and Quality in Primary Care (PMAQ-AB). The responses of users who underwent dental consultations with the Oral Health Team (OHT) and of whom the service had a full record were analyzed using logistic regression. Regarding the dependent variable ‘User satisfaction’, 87% of the users (n=2,047) stated that they were satisfied with the care they receive from the OHT. Dissatisfaction was influenced by the fact that user was never or almost never guided about his/her oral health care (OR=4.27); insufficient consultation time (OR=3.38); professionals do not register the user condition in his/her medical record (OR=1.97); OHT does not operate in the afternoons (OR=1.66); dental care schedule does not meet the user needs (OR=2.86); OHT does not search for the user when either he/she interrupts the treatment or does not attend a dental appointment so to follow up and resume the service (OR=1.59). Therefore, the percentage of users satisfied with the oral health care in Paraíba is significant, being the factors that influence user satisfaction mainly associated with meeting users’ needs and work process organization.

RESUMO Objetivou-se identificar os fatores associados à satisfação dos usuários com a oferta de cuidado em saúde bucal na Paraíba a partir de dados do 2º ciclo de avaliação externa do Programa Nacional de Melhoria do Acesso e da Qualidade da Atenção Básica (PMAQ-AB). As respostas dos usuários que passaram por consulta odontológica com a Equipe de Saúde Bucal (ESB) e possuíam dados completos foram analisadas por meio de regressão logística. Em relação à variável dependente ‘Satisfação do usuário’, 87% dos usuários (n=2.047), afirmaram estar satisfeitos com o cuidado que recebem da ESB. A insatisfação foi influenciada pelo fato de o usuário nunca ou quase nunca ser orientado sobre os cuidados com a sua saúde bucal (OR=4,27); o tempo da consulta ser insuficiente (OR=3,38); os profissionais não fazerem anotações no prontuário ou ficha (OR=1,97); a ESB não atender no turno da tarde (OR=1,66); o horário do atendimento odontológico não satisfazer às necessidades dos usuários (OR=2,86); e a ESB não procurar o usuário quando este interrompe o tratamento ou não comparece à consulta odontológica para saber o que aconteceu e retomar o atendimento (OR=1,59). Conclui-se ser expressivo o percentual de usuários satisfeitos com a atenção em saúde bucal na Paraíba, estando os fatores que influenciam a satisfação relacionados principalmente ao atendimento das necessidades dos usuários e ao processo de trabalho da ESB.

ABSTRACT The objective of this study was to identify the factors associated with the user’s satisfaction about the provision of oral health care in the State of Paraíba. The research based on data regarding the 2nd cycle of the external evaluation of the National Program for Improving Access and Quality in Primary Care (PMAQ-AB). The responses of users who underwent dental consultations with the Oral Health Team (OHT) and of whom the service had a full record were analyzed using logistic regression. Regarding the dependent variable ‘User satisfaction’, 87% of the users (n=2,047) stated that they were satisfied with the care they receive from the OHT. Dissatisfaction was influenced by the fact that user was never or almost never guided about his/her oral health care (OR=4.27); insufficient consultation time (OR=3.38); professionals do not register the user condition in his/her medical record (OR=1.97); OHT does not operate in the afternoons (OR=1.66); dental care schedule does not meet the user needs (OR=2.86); OHT does not search for the user when either he/she interrupts the treatment or does not attend a dental appointment so to follow up and resume the service (OR=1.59). Therefore, the percentage of users satisfied with the oral health care in Paraíba is significant, being the factors that influence user satisfaction mainly associated with meeting users’ needs and work process organization.

Resumo Este estudo objetivou avaliar os fatores associados com a ocorrência de mucosite oral grave (SOM) em pacientes pediátricos oncológicos durante o tratamento quimioterápico. Trata-se de um estudo de caso-controle aninhado a uma coorte prospectiva que monitorou 105 pacientes por 10 semanas consecutivas após o início do tratamento quimioterápico. Regressão logística foi utilizada para identificar os fatores associados com a MOG, por grupo de malignidade (tumores hematológicos ou sólidos) (Sig.=5%). Para pacientes com tumores hematológicos foram encontrados fatores associados com a MOG em duas semanas de tratamento: na 6ª semana (aumento na frequência de doses de quimioterapia (OR=3,02)) e na 7ª semana (sexo feminino (OR=21,28); e aumento na frequência de doses de quimioterapia (OR=2,51)); e para pacientes com tumores sólidos foram encontrados fatores associados com MOG em cinco semanas de tratamento: na 1ª semana (sexo feminino (OR=14,43), aumento na idade (OR=1,24)); na 2ª semana (Miscelânea (OR=6,39)); na 5ª semana (Antimetabólitos (OR=17,44); Miscelânea (OR=45,42); e redução de plaquetas (OR=1,12)); na 6ª semana (aumento na creatinina (OR=1,63)); e na 7ª semana (aumento na creatinina (OR=2,39)). Para pacientes com tumores hematológicos, ser do sexo feminino e o aumento na frequência de doses de quimioterapia aumentou o risco para MOG; e, para pacientes com tumors sólidos, ser do sexo feminino, o aumento na idade e nos níveis de concentração sanguínea de creatinina, a redução no número de plaquetas e o uso de quimioterapia com agentes das classes Miscelânea e Antimetabólitos estiveram associados com o aumento no risco para a ocorrência de MOG.

Abstract This study aimed to evaluate the factors associated with the occurrence of severe oral mucositis (SOM) in pediatric oncology patients during the chemotherapeutic treatment. This is a nested case-control to a prospective cohort that monitored 105 patients for 10 consecutive weeks after the beginning of the chemotherapy treatment. Logistic regression was used to identify the factors associated with SOM, by group of malignancy (hematologic or solid tumors) (Sig.=5%). To patients with hematologic tumors were found factors associated with SOM in two weeks of treatment: in the 6th week (increase in frequency of chemotherapy doses (OR=3.02)) and in the 7th week (female sex (OR=21.28); and increase in frequency of chemotherapy doses (OR=2.51)); and to patients with solid tumors were found factors associated with SOM in five weeks of treatment: in the 1st week (female sex (OR=14.43); age increase (OR=1.24)); in the 2nd week (Miscellany (OR=6.39)); in the 5th week (Antimetabolites (OR=17.44); Miscellany (OR=45.42); and platelets reduction (OR=1.12)); in the 6th week (creatinine increase (OR=1.63)); and in the 7th week (creatinine increase (OR=2.39)). For patients with hematologic tumors, to be female, and the increase in the frequency of chemotherapy doses increased the risk for SOM and for patients with solid tumors, to be female, the increase in age and in level blood concentration of creatinine, the reduction in number of platelets and the use of chemotherapy with miscellany and antimetabolites agents were associated with an increase in risk for occurrence of SOM.

Abstract Objective: To determine the occurrence and severity of oral mucositis (OM) and the factors associated with the onset of severe oral mucositis (SOM) in pediatric cancer patients. Material and Methods: This was a longitudinal and prospective study with 85 children and adolescents (aged 0 to 19 years) admitted to the Pediatric Oncology Sector of Napoleão Laureano Hospital between November 2016 and July 2019. The patients’ sociodemographic and epidemiological information, as well as hematological and biochemical parameters, were obtained from their medical charts. The oral mucosa of study participants was assessed through the modified Oral Assessment Guide (OAG) at baseline and after the 2nd, 5th and 10th week of antineoplastic treatment. Data were analyzed by Chi-square test to determine the factors associated with the occurrence of SOM (p<0.05). Results: The occurrence of OM was more frequent in the 2nd (60%), 5th (40.9%) and 10th week (43.2%) of antineoplastic treatment. During the follow-up period, SOM was more frequent in the 5th week (34.7%), followed by the 2nd (32.3%) and 10th weeks (29.7%). There was no association between the occurrence of SOM and the patient's age, type of tumor, chemotherapy regimen, and hematological and biochemical parameters. Conclusion: The occurrence of oral mucositis in pediatric cancer patients was significant, especially in the 2nd week of antineoplastic treatment. Severe oral mucositis was more prevalent in the 5th week of treatment and was not associated with any of the study variables.

Abstract Objective: This study sought to identify the differences between the oral changes presented by patients with solid and hematologic tumors during chemotherapeutic treatment. Methodology: This is an observational, prospective and quantitative study using direct documentation by follow-up of 105 patients from 0 to 18 years using the modified Oral Assessment Guide (OAG). Of the 105 patients analyzed, 57 (54.3%) were boys with 7.3 years (±5.2) mean age. Hematologic neoplasms accounted for 51.4% of all cases. Results: Voice, lips, tongue, and saliva changes were not significantly different (p>0.05) between patients with solid or hematologic tumors and during the follow-up. From the 6th until the 10th week of chemotherapeutic treatment alterations in swallowing function, in the mucous membrane (buccal mucosa and palate), in the labial mucosa, and in the gingiva occurred and were distributed differently between the two tumors groups (p<0.05). The main alterations were observed in patients with hematologic tumors. Conclusion: It was concluded that the oral changes during the chemotherapeutic treatment occurred especially in swallowing function, in the mucous membrane, in the labial mucosa and in the gingiva, and these alterations were found mainly in patients with hematologic tumors.