Abstract Introduction: Renal osteodystrophy (ROD) refers to a group of bone morphological patterns that derive from distinct pathophysiological mechanisms. Whether the ROD subtypes influence long-term outcomes is unknown. Our objective was to explore the relationship between ROD and clinical outcomes. Methods: This study is a subanalysis of the Brazilian Registry of Bone Biopsies (REBRABO). Samples from individual patients were classified as having osteitis fibrosa (OF), mixed uremic osteodystrophy (MUO), adynamic bone disease (ABD), osteomalacia (OM), normal/minor alterations, and according to turnover/mineralization/volume (TMV) system. Patients were followed for 3.4 yrs. Clinical outcomes were: bone fractures, hospitalization, major adverse cardiovascular events (MACE), and death. Results: We enrolled 275 participants, of which 248 (90%) were on dialysis. At follow-up, 28 bone fractures, 97 hospitalizations, 44 MACE, and 70 deaths were recorded. ROD subtypes were not related to outcomes. Conclusion: The incidence of clinical outcomes did not differ between the types of ROD. Introduction (ROD mechanisms longterm long term unknown Methods REBRABO. REBRABO . (REBRABO) OF, OF , (OF) MUO, MUO (MUO) ABD, ABD (ABD) OM, OM (OM) normalminor normal minor alterations turnovermineralizationvolume turnover mineralization volume TMV (TMV system 34 3 4 3. yrs fractures hospitalization MACE (MACE) death Results 27 participants 24 90% 90 (90% dialysis followup, followup follow up, up follow-up 2 9 hospitalizations 7 recorded Conclusion (REBRABO (OF (MUO (ABD (OM (MACE (90 (9 (

Resumo Introdução: Osteodistrofia renal (OR) refere-se a um grupo de padrões morfológicos ósseos que decorrem de mecanismos fisiopatológicos distintos. É desconhecido se os subtipos de OR influenciam desfechos em longo prazo. Nosso objetivo foi explorar as relações entre OR e desfechos. Métodos: Este estudo é uma subanálise do Registro Brasileiro de Biópsias Ósseas (REBRABO). As amostras de cada paciente foram classificadas em osteíte fibrosa (OF), osteodistrofia urêmica mista (MUO), doença óssea adinâmica (ABD), osteomalácia (OM), alterações normais/menores, e pelo sistema Remodelação / Mineralização / Volume (RMV). Os pacientes foram acompanhados por 3,4 anos. Os eventos clínicos foram: fraturas ósseas, hospitalizações, eventos cardiovasculares adversos maiores (MACE), e óbito. Resultados: Analisamos 275 indivíduos, 248 (90%) deles estavam em diálise. No acompanhamento, 28 fraturas ósseas, 97 hospitalizações, 44 MACE e 70 óbitos foram registrados. Os subtipos de OR não foram relacionados aos desfechos clínicos. Conclusão: A incidência de desfechos clínicos não diferiu entre os tipos de OR. Introdução (OR referese refere distintos prazo Métodos REBRABO. REBRABO . (REBRABO) OF, OF , (OF) MUO, MUO (MUO) ABD, ABD (ABD) OM, OM (OM) normaismenores normais menores normais/menores RMV. RMV (RMV) 34 3 4 3, anos ósseas hospitalizações MACE, (MACE) óbito Resultados 27 indivíduos 24 90% 90 (90% diálise acompanhamento 2 9 7 registrados Conclusão (REBRABO (OF (MUO (ABD (OM (RMV (MACE (90 (9 (

Abstract Introduction: Bone cancer metastasis may produce severe and refractory pain. It is often difficult to manage with systemic analgesics. Chemical neurolysis may be an effective alternative in terminally ill patients. Case report: Female terminally ill patient with hip metastasis of gastric cancer in severe pain. Neurolytic ultrasound-guided blocks of the pericapsular nerve group and obturator nerve were performed with 5% phenol. This led to satisfactory pain relief for 10 days, until the patient’s death. Discussion: This approach may be effective and safe as an analgesic option for refractory hip pain due to metastasis or pathologic fracture in terminally ill patients. Introduction analgesics patients report ultrasoundguided ultrasound guided 5 phenol 1 days s death Discussion

Abstract The objective of this article is to analyze the scientific production of the Professional Master's Degree in Social Sciences for Secondary Education (MPCS), at the Joaquim Nabuco Foundation, based on the student’s course completion works (TCCs). Considering Teaching Sociology a subfield of Social Sciences and Education, we consider that TCCs operate in this space as products and producers of discourse. The meanings and representations expressed in the texts were examined based on content analysis, using the MAXQDA software. Although the MPCS is a professional master's degree, the study revealed that the TCCs adopted the dissertation model, albeit with varied methodologies, and the most frequent keyword is “sociology”, and not “teaching sociology”. Among the themes, the most explored one was teaching methodology. Masters Master s MPCS, , (MPCS) Foundation students student TCCs. . (TCCs) discourse analysis software masters master degree model methodologies sociology, sociology “sociology” sociology. sociology” themes methodology (MPCS (TCCs “sociology

Resumo O objetivo deste artigo é analisar a produção científica do Mestrado Profissional em Ciências Sociais para o Ensino Médio (MPCS), da Fundação Joaquim Nabuco, a partir dos seus trabalhos de conclusão de curso (TCCs). Considerando o Ensino de Sociologia um subcampo das Ciências Sociais e da Educação, ponderamos que os TCCs operam neste espaço como produtos e produtores de discurso. Os sentidos e as representações expressos nos textos foram examinados a partir da análise de conteúdo, utilizando o software MAXQDA. Apesar de o MPCS ser um mestrado profissional, o estudo revelou que os TCCs adotaram o modelo dissertação, ainda que com metodologias variadas, e a palavra-chave mais frequente é “sociologia”, e não “ensino de sociologia”. Dentre os temas, o mais explorado foi metodologia de ensino. MPCS, , (MPCS) Nabuco TCCs. . (TCCs) Educação discurso conteúdo MAXQDA profissional dissertação variadas palavrachave palavra chave sociologia, sociologia “sociologia” ensino sociologia. sociologia” temas (MPCS (TCCs “sociologia

Resumen El objetivo del artículo es analizar la producción científica del Máster Profesional en Ciencias Sociales en la Educación Secundaria (MPCS), de la Fundación Joaquim Nabuco, a partir de los trabajos de conclusión de curso (TCCs). Considerando la enseñanza de Sociología un subcampo de las Ciencias Sociales y de la Educación, creemos que los TCCs son productos y productores de discurso. Los sentidos y las representaciones fueran examinados a partir del análisis de contenido, usando el software MAXQDA. Mientras el MPCS sea un máster professional, el estudio reveló que los TCCs adoptaran el modelo disertación, aunque con diferentes metodologías, e la palabra clave “sociología” es más frecuente que “enseñanza de sociología”. Entre los temas, el más explorado fue metodologia de enseñanza. MPCS, , (MPCS) Nabuco TCCs. . (TCCs) discurso contenido MAXQDA professional disertación metodologías sociología “sociología sociología. sociología” temas (MPCS (TCCs

ABSTRACT OBJECTIVE This study aims to propose a comprehensive alternative to the Bland-Altman plot method, addressing its limitations and providing a statistical framework for evaluating the equivalences of measurement techniques. This involves introducing an innovative three-step approach for assessing accuracy, precision, and agreement between techniques, which enhances objectivity in equivalence assessment. Additionally, the development of an R package that is easy to use enables researchers to efficiently analyze and interpret technique equivalences. METHODS Inferential statistics support for equivalence between measurement techniques was proposed in three nested tests. These were based on structural regressions with the goal to assess the equivalence of structural means (accuracy), the equivalence of structural variances (precision), and concordance with the structural bisector line (agreement in measurements obtained from the same subject), using analytical methods and robust approach by bootstrapping. To promote better understanding, graphical outputs following Bland and Altman’s principles were also implemented. RESULTS The performance of this method was shown and confronted by five data sets from previously published articles that used Bland and Altman’s method. One case demonstrated strict equivalence, three cases showed partial equivalence, and one showed poor equivalence. The developed R package containing open codes and data are available for free and with installation instructions at Harvard Dataverse at https://doi.org/10.7910/DVN/AGJPZH. CONCLUSION Although easy to communicate, the widely cited and applied Bland and Altman plot method is often misinterpreted, since it lacks suitable inferential statistical support. Common alternatives, such as Pearson’s correlation or ordinal least-square linear regression, also fail to locate the weakness of each measurement technique. It may be possible to test whether two techniques have full equivalence by preserving graphical communication, in accordance with Bland and Altman’s principles, but also adding robust and suitable inferential statistics. Decomposing equivalence into three features (accuracy, precision, and agreement) helps to locate the sources of the problem when fixing a new technique. BlandAltman threestep step accuracy precision assessment Additionally tests , (accuracy) (precision) subject, subject subject) bootstrapping understanding Altmans s implemented https//doi.org/10.7910/DVN/AGJPZH. httpsdoiorg107910DVNAGJPZH httpsdoiorgDVNAGJPZH https //doi.org/10.7910/DVN/AGJPZH. doi org 10 7910 DVN AGJPZH https://doi.org/10.7910/DVN/AGJPZH communicate misinterpreted alternatives Pearsons Pearson leastsquare least square regression communication (accuracy (precision https//doi.org/10.7910/DVN/AGJPZH httpsdoiorg DVNAGJPZH doiorg107910DVNAGJPZH doiorgDVNAGJPZH //doi.org/10.7910/DVN/AGJPZH 1 791 doiorg 79 7

Abstract Background: Alarms alert healthcare professionals of deviations from normal/physiologic status. However, alarm fatigue may occur when their high pitch and diversity overwhelm clinicians, possibly leading to alarms being disabled, paused, and/or ignored. We aimed to determine whether a staff educational program on customizing alarm settings of bedside monitors may decrease inconsistent alarms in the Post-Anesthesia Care Unit (PACU). Methods: This is a prospective, analytic, quantitative, pragmatic, open-label, single-arm study. The outcome was evaluated on PACU admission before (P1) and after (P2) the implementation of the educational program. The heart rate, blood pressure, and oxygen saturation alarms were selected for clinical consistency. Results: A total of 260 patients were included and 344 clinical alarms collected, with 270 (78.4%) before (P1), and 74 (21.6%) after (P2) the intervention. Among the 270 alarms in P1, 45.2% were inconsistent (i.e., false alarms), compared to 9.4% of the 74 in P2. Patients with consistent alarms occurred in 30% in the P1 and 27% in the P2 (p = 0.08). Patients with inconsistent alarms occurred in 25.4% in the P1 and in 3.8% in the P2. Ignored consistent alarms were reduced from 21.5% to 2.6% (p = 0.004) in the P2 group. The educational program was a protective factor for the inconsistent clinical alarm (OR = 0.11 [95% CI 0.04-0.3]; p < 0.001) after adjustments for age, gender, and ASA physical status. Conclusion: Customizing alarm settings on PACU admission proved to be a protective factor against inconsistent alarm notifications of multiparametric monitors. Background normalphysiologic normal physiologic status However clinicians disabled paused andor or ignored PostAnesthesia Post Anesthesia PACU. . (PACU) Methods prospective analytic quantitative pragmatic openlabel, openlabel open label, label open-label singlearm single arm study P (P1 (P2 rate pressure consistency Results 26 34 collected 27 78.4% 784 78 4 (78.4% , 7 21.6% 216 21 6 (21.6% intervention 452 45 2 45.2 i.e., ie i e (i.e. alarms, alarms) 94 9 9.4 30 0.08. 008 0.08 0 08 0.08) 254 25 25.4 38 3 8 3.8 215 5 21.5 2.6 0.004 0004 004 group OR 011 11 0.1 95% 95 [95 0.040.3 00403 0.04 0.3 04 0.04-0.3] 0.001 0001 001 age gender Conclusion (PACU (P 78.4 (78.4 21.6 (21.6 45. i.e. (i.e 9. 00 0.0 25. 3. 21. 2. 0.00 000 01 1 0. [9 040 0.040. 0040 03 0.04-0.3 78. (78. (21. i.e [ 0.040 0.04-0. (78 (21 0.04-0 (7 (2 0.04- (

Abstract Background: Myelomeningocele (MMC) is a neural tube defect disease. Antenatal repair of fetal MMC is an alternative to postnatal repair. Many agents can be used as tocolytics during the in utero fetal repair such as β2-agonists and oxytocin receptor antagonists, with possible maternal and fetal repercussions. This study aims to compare maternal arterial blood gas analysis between terbutaline or atosiban, as tocolytic agents, during intrauterine MMC repair. Methods: Retrospective cohort study. Patients were divided into two groups depending on the main tocolytic agent used during intrauterine MMC repair: atosiban (16) or terbutaline (9). Maternal arterial blood gas samples were analyzed on three moments: post induction (baseline, before the start of tocolysis), before extubation, and two hours after the end of the surgery. Results: Twenty-five patients were included and assessed. Before extubation, the terbutaline group showed lower arterial pH (7.347 ± 0.05 vs. 7.396 ± 0.02 for atosiban, p = 0.006) and higher arterial lactate (28.33 ± 12.76 mg.dL–1 vs. 13.06 ± 6.35 mg.dL–1, for atosiban, p = 0.001) levels. Conclusions: Patients who received terbutaline had more acidosis and higher levels of lactate, compared to those who received atosiban, during intrauterine fetal MMC repair. Background (MMC disease β2agonists βagonists β2 agonists β antagonists repercussions Methods 16 (16 9. 9 . (9) moments baseline, baseline (baseline tocolysis, tocolysis , tocolysis) extubation surgery Results Twentyfive Twenty five assessed 7.347 7347 7 347 (7.34 005 0 05 0.0 vs 7396 396 7.39 002 02 0.006 0006 006 28.33 2833 28 33 (28.3 1276 12 76 12.7 mgdL1 mgdL mg dL 1 mg.dL– 1306 13 06 13.0 635 6 35 6.3 0.001 0001 001 Conclusions (1 (9 7.34 734 34 (7.3 00 0. 739 39 7.3 0.00 000 28.3 283 2 3 (28. 127 12. mg.dL 130 13. 63 6. ( 73 (7. 7. 28. (28 (7 (2

ABSTRACT OBJECTIVE This study aims to propose a comprehensive alternative to the Bland-Altman plot method, addressing its limitations and providing a statistical framework for evaluating the equivalences of measurement techniques. This involves introducing an innovative three-step approach for assessing accuracy, precision, and agreement between techniques, which enhances objectivity in equivalence assessment. Additionally, the development of an R package that is easy to use enables researchers to efficiently analyze and interpret technique equivalences. METHODS Inferential statistics support for equivalence between measurement techniques was proposed in three nested tests. These were based on structural regressions with the goal to assess the equivalence of structural means (accuracy), the equivalence of structural variances (precision), and concordance with the structural bisector line (agreement in measurements obtained from the same subject), using analytical methods and robust approach by bootstrapping. To promote better understanding, graphical outputs following Bland and Altman’s principles were also implemented. RESULTS The performance of this method was shown and confronted by five data sets from previously published articles that used Bland and Altman’s method. One case demonstrated strict equivalence, three cases showed partial equivalence, and one showed poor equivalence. The developed R package containing open codes and data are available for free and with installation instructions at Harvard Dataverse at https://doi.org/10.7910/DVN/AGJPZH. CONCLUSION Although easy to communicate, the widely cited and applied Bland and Altman plot method is often misinterpreted, since it lacks suitable inferential statistical support. Common alternatives, such as Pearson’s correlation or ordinal least-square linear regression, also fail to locate the weakness of each measurement technique. It may be possible to test whether two techniques have full equivalence by preserving graphical communication, in accordance with Bland and Altman’s principles, but also adding robust and suitable inferential statistics. Decomposing equivalence into three features (accuracy, precision, and agreement) helps to locate the sources of the problem when fixing a new technique.

Abstract Introduction: Renal osteodystrophy (ROD) refers to a group of bone morphological patterns that derive from distinct pathophysiological mechanisms. Whether the ROD subtypes influence long-term outcomes is unknown. Our objective was to explore the relationship between ROD and clinical outcomes. Methods: This study is a subanalysis of the Brazilian Registry of Bone Biopsies (REBRABO). Samples from individual patients were classified as having osteitis fibrosa (OF), mixed uremic osteodystrophy (MUO), adynamic bone disease (ABD), osteomalacia (OM), normal/minor alterations, and according to turnover/mineralization/volume (TMV) system. Patients were followed for 3.4 yrs. Clinical outcomes were: bone fractures, hospitalization, major adverse cardiovascular events (MACE), and death. Results: We enrolled 275 participants, of which 248 (90%) were on dialysis. At follow-up, 28 bone fractures, 97 hospitalizations, 44 MACE, and 70 deaths were recorded. ROD subtypes were not related to outcomes. Conclusion: The incidence of clinical outcomes did not differ between the types of ROD.

Resumo Introdução: Osteodistrofia renal (OR) refere-se a um grupo de padrões morfológicos ósseos que decorrem de mecanismos fisiopatológicos distintos. É desconhecido se os subtipos de OR influenciam desfechos em longo prazo. Nosso objetivo foi explorar as relações entre OR e desfechos. Métodos: Este estudo é uma subanálise do Registro Brasileiro de Biópsias Ósseas (REBRABO). As amostras de cada paciente foram classificadas em osteíte fibrosa (OF), osteodistrofia urêmica mista (MUO), doença óssea adinâmica (ABD), osteomalácia (OM), alterações normais/menores, e pelo sistema Remodelação / Mineralização / Volume (RMV). Os pacientes foram acompanhados por 3,4 anos. Os eventos clínicos foram: fraturas ósseas, hospitalizações, eventos cardiovasculares adversos maiores (MACE), e óbito. Resultados: Analisamos 275 indivíduos, 248 (90%) deles estavam em diálise. No acompanhamento, 28 fraturas ósseas, 97 hospitalizações, 44 MACE e 70 óbitos foram registrados. Os subtipos de OR não foram relacionados aos desfechos clínicos. Conclusão: A incidência de desfechos clínicos não diferiu entre os tipos de OR.

SUMMARY OBJECTIVE: The aim of this study was to identify predictive factors for complications after percutaneous nephrolithotomy. METHODS: We prospectively analyzed patients who underwent percutaneous nephrolithotomy from June 2011 to October 2018. The association of preoperative and intraoperative factors with the presence of complications was assessed using univariate and multivariate analyses. The significance level was set at p<0.05. RESULTS: A total of 1,066 surgeries were evaluated, and the overall complication rate was 14.9%. In all, 105 (9.8%) surgeries were performed in the prone position, and 961 (90.2%) were performed in the supine position. Univariate analysis demonstrated that surgical position, upper pole puncture, surgical time, number of tracts, and Guys Stone Score were associated with complications. In multivariate analyses, prone position (odds ratio [OR] 2.10; p=0.003), surgical time ≥90 min (OR 1.76; p=0.014), upper pole puncture (OR 2.48; p<0.001), and Guys Stone Score 3 or 4 (OR 1.90; p=0.033) were independent predictive factors for complications after percutaneous nephrolithotomy. CONCLUSION: Performing percutaneous nephrolithotomy in the supine position, in under 90 min, and avoiding upper pole punctures may reduce complications during the treatment of large kidney stones. OBJECTIVE METHODS 201 2018 analyses p005 p 0 05 p<0.05 RESULTS 1066 1 066 1,06 evaluated 149 14 9 14.9% all 10 9.8% 98 8 (9.8% 96 90.2% 902 2 (90.2% tracts odds OR [OR 2.10 210 p=0.003, p0003 p=0.003 , 003 p=0.003) ≥9 1.76 176 76 p=0.014, p0014 p=0.014 014 p=0.014) 2.48 248 48 p<0.001, p0001 p<0.001 001 p<0.001) 1.90 190 p=0.033 p0033 033 CONCLUSION stones 20 p00 p<0.0 106 06 1,0 14.9 9.8 (9.8 90.2 (90.2 2.1 21 p000 p=0.00 00 ≥ 1.7 17 7 p001 p=0.01 01 2.4 24 p<0.00 1.9 19 p=0.03 p003 03 p0 p<0. 1, 14. 9. (9. 90. (90. 2. p=0.0 1. p<0 (9 (90 p=0. p< ( p=0 p=

Abstract: Introduction: A 2010 study pointed out the future needs of medical education, with integrated contents and practices, fostered by virtual educational technology and by prioritizing competence, not time. Anatomy, indistinguishable from other fundamentals of medicine, faces restrictions on cadaver dissection. Objective: Essay on the teaching of anatomy in clinical contexts and the use of technologies Method: The “pubmed” platform of the National Library of Medicine and descriptors ((anatomy[MeSH Terms]) AND (method, teaching[MeSH Terms])) AND (surgery[MeSH Terms]) were used. Result: There are indications of 316 articles in the period 2000-2022 (June 2022). The main question about the teaching of Anatomy is the replacement of the dissection technique and, consequently, the use of the cadaver. Studies suggest maintaining the use of dissection, prosection and greater use of digital and model means. Conclusion: Cadaveric material should be secured with greater use of prosection and dissection being directed or elective. Virtual reality and permanent material must be assimilated as instrumental and supervised by qualified anatomists and enriched by interpretation and clinical applicability. Abstract Introduction 201 education practices competence time medicine Objective Method pubmed “pubmed anatomyMeSH MeSH Terms Terms] method, method (method teachingMeSH surgeryMeSH surgery used Result 31 20002022 2000 2022 2000-202 June 2022. . 2022) consequently means Conclusion elective applicability 20 3 2000202 200 202 2000-20 2 200020 2000-2 20002 2000-

Resumo: Introdução: Um estudo de 2010 apontou as necessidades futuras da educação médica, com conteúdos e práticas integrados, fomentada pela tecnologia educacional virtual e pela prioridade na competência, não no tempo. A anatomia, indistinta de outros fundamentos da medicina, enfrenta restrições à dissecção de cadáveres. Objetivo: Ensaio sobre o ensino da anatomia em contextos clínicos e com emprego de tecnologias. Método: Utilizaram-se a plataforma PubMed da National Library of Medicine e os descritores ((anatomy [MeSH Terms]) AND (method, teaching [MeSH Terms])) AND (surgery [MeSH Terms]). Resultado: Há indicação de 316 artigos no período 2000-2022 (junho de 2022). A principal pergunta sobre o ensino de anatomia refere-se à substituição da técnica de dissecção e, por consequência, do uso do cadáver. Estudos sugerem a manutenção do uso da dissecção, da prossecção e de maior uso de meios digitais e modelares. Conclusão: O material cadavérico deve ser garantido com maior uso da prossecção, com a dissecção sendo dirigida ou eletiva. Realidade virtual e material de prossecção devem ser assimilados como instrumentais e supervisionados por anatomistas qualificados e enriquecidos pela interpretação e aplicabilidade clínica. Resumo Introdução 201 médica integrados competência tempo medicina cadáveres Objetivo tecnologias Método Utilizaramse Utilizaram se anatomy MeSH Terms Terms] method, method (method surgery Terms. . Resultado 31 20002022 2000 2022 2000-202 junho 2022. 2022) referese refere consequência cadáver modelares Conclusão eletiva clínica 20 3 2000202 200 202 2000-20 2 200020 2000-2 20002 2000-

Abstract Background: Home-based virtual reality technology may become an alternative to cardiac rehabilitation. Objectives: To evaluate the effects of a specific, home-based exercise program, performed either through a virtual reality (Kinect) or a conventional format (booklet) in the maintenance stage of cardiac rehabilitation for six months on functional muscle strength of the lower limbs, physical activity and exercise tolerance. Methodology: This is a randomized clinical trial (ClinicalTrials.gov — NCT02753829) with individuals with coronary artery disease from a hospital in Porto, Portugal, randomly allocated to an experimental group “1” (EG1; n = 11), submitted to a virtual reality exercise program (Kinect); an experimental group “2” (EG2; n = 11), submitted to an exercise program described in a booklet (conventional format); or a control group (CG) (n=11), submitted to routine care. Parameters of functional muscle strength of the lower limbs (sit-to-stand test), physical activity (accelerometer) and exercise tolerance (stress test) were assessed and compared between the groups. Descriptive and inferential statistics were applied, with 95% with a significance level of 0.05. Results: Significant improvements in functional muscle strength of the lower limbs were observed in EG1 compared to EG2, at three months (19.5 ± 7.7 versus 11.9 ± 4.7, p = 0.042), and at six months (23.0 ± 7.7 versus 14.6 ± 4.6, p = 0.027) of intervention. Conclusions: The program did not demonstrate superior results, in relation to the control group and among the different formats, in physical activity and effort tolerance. In relation to the functional muscle strength of the lower limbs, the virtual reality format showed significantly better results when compared to the conventional format only. Background Homebased Home based Objectives specific homebased home Kinect (Kinect (booklet Methodology ClinicalTrials.gov ClinicalTrialsgov ClinicalTrials gov NCT02753829 NCT Porto Portugal 1 “1 EG (EG1 11, 11 , 11) 2 “2 EG2 (EG2 format) CG (CG n=11, n11 n=11 (n=11) care sittostand sit stand test, test accelerometer (accelerometer stress groups applied 95 005 0 05 0.05 Results 19.5 195 19 5 (19. 77 7 7. 119 9 11. 47 4 4.7 0.042, 0042 0.042 042 0.042) 23.0 230 23 (23. 146 14 6 14. 46 4.6 0.027 0027 027 intervention Conclusions formats only NCT0275382 “ (EG n1 n=1 (n=11 00 0.0 19. (19 4. 004 0.04 04 23. (23 0.02 002 02 NCT027538 n= (n=1 0. (1 (2 NCT02753 (n= ( NCT0275 (n NCT027 NCT02 NCT0

Abstract The sugary cassava cultivar BRS 438 has high roots yield (with expressive concentration of free sugars), adaptation to mechanized planting, and moderate resistance to bacterial diseases. These characteristics make it an option for production of sugars, alcohol, and animal feed (additive in forage grass silage), among other possibilities. 43 with sugars , sugars) planting diseases alcohol additive silage, silage silage) possibilities 4

SUMMARY OBJECTIVE: The aim of this study was to evaluate the predictive factors for success following percutaneous nephrolithotomy in the supine position. METHODS: Patients who underwent percutaneous nephrolithotomy in the supine position from June 2011 to October 2018 were evaluated. Age, sex, body mass index, the American Society of Anesthesiologists physical status classification, hemoglobin level, number of previous surgeries, stone size, and the Guy’s Stone Score were analyzed. Success was considered if no fragments were observed on the computed tomography scan on the first postoperative day. Univariate and multivariate analyses were performed to determine significant parameters. RESULTS: We evaluated 961 patients; of them, 483 (50.2%) underwent previous stone-related surgery, and 499 (51.9%) had Guy’s Stone Score 3 or 4. The overall success rate in a single procedure was 40.7%, and complication rate was 13.7%. The univariate analysis showed that the maximum diameter of the stone (25.10±10 mm; p<0.001), previous percutaneous nephrolithotomy (OR 0.52; p<0.001), number of previous percutaneous nephrolithotomy (OR 0.15; p<0.001), the Guy’s Stone Score (OR 0.28; p<0.001), and the number of tracts (OR 0.32; p<0.001) were significant. In the multivariate analysis, the number of previous percutaneous nephrolithotomy (OR 0.54; p<0.001) and the Guy’s Stone Score (OR 0.25; p<0.001) were statically significant. CONCLUSIONS: Guy’s Stone Score and the number of previous percutaneous nephrolithotomy are predictors of success with the supine position. Complex cases and with previous percutaneous interventions may require technical improvements to achieve higher stone-free rates.

Abstract Objective: Postoperative cognitive dysfunction may result from worsening in a condition of previous impairment. It causes greater difficulty in recovery, longer hospital stays, and consequent delay in returning to work activities. Digital games have a potential neuromodulatory and rehabilitation effect. In this study, a digital game was used as a neuropsychological test to assess postoperative cognitive dysfunction, with preoperative patient performance as control. Methods: It was a non-controlled study, with patients selected among candidates for elective non-cardiac surgery, evaluated in the preand postoperative periods. The digital game used has six phases developed to evaluate selective attention, alternating attention, visuoperception, inhibitory control, short-term memory, and long-term memory. The digital game takes about 25 minutes. Scores are the sum of correct answers in each cognitive domain. Statistical analysis compared these cognitive functions preand post-surgery using a generalized linear mixed model (ANCOVA). Results: Sixty patients were evaluated, 40% male and 60% female, with a mean age of 52.7 ± 13.5 years. Except for visuoperception, a reduction in post-surgery scores was found in all phases of the digital game. Conclusion: The digital game was able to detect decline in several cognitive functions postoperatively. As its completion is faster than in conventional tests on paper, this digital game may be a potentially recommended tool for assessing patients, especially the elderly and in the early postoperative period.

Abstract Objective: Cognitive dysfunction may occur postoperatively. Fast and efficient assessment of Postoperative Cognitive Dysfunction (POCD) can minimize loss of quality of life, and therefore, a study comparing a digital game with standard neuropsychological tests to assess executive, mnemonic, and attention functions to evaluate POCD seems to be relevant both for research and clinical practice. Methods: A battery of standardized tests and a digital game (MentalPlus®) were administered to 60 patients at the Central Institute of Hospital das Clínicas in São Paulo (36 women and 24 men), with ages between 29 and 82 years, preand post-surgery performed under anesthesia. Correlation and linear regression model were used to compare the scores obtained from the standardized tests to the scores of the six executive and cognitive functions evaluated by the game (shortand long-term memory, selective and alternating attention, inhibitory control, and visual perception). Results: After correlation analysis, a statistically significant result was found mainly for the correlation between the scores from the phase of the digital game assessing the visuoperception function and the scores from the A and B cards of the Stroop Test (p < 0.001, r = 0.99 and r = 0.64, respectively), and the scores from TMTA (p = 0.0046, r = 0.51). We also found a moderate correlation between the phase of the game assessing short-memory function and VVLT (p < 0.001, r = 0.41). No statistically significant correlations were found for the other functions assessed. Conclusion: The digital game provided scores in agreement with standardized tests for evaluating visual perception and possibly short-term memory cognitive functions. Further studies are necessary to verify the correlation of other phases of the digital game with standardized tests assessing cognitive functions.