Pesquisa | SciELO

Abstract In the modern world, cancer is a growing cause of mortality, but archeological studies have shown that it is not exclusive to modern populations. The aim of this study is to examine the epidemiologic, social, and clinicopathologic features of head and neck cancers in ancient populations. To do this, we extracted all records that described malignant lesions in the head and neck region available in the Cancer Research in Ancient Bodies Database (CRAB). The estimated age, sex, physical condition of the remains (skeletonized, mummified), anatomic location of tumors, geographic location, chronology, tumor type, and methods of tumor diagnosis were collected. One hundred and sixty-seven cases were found, mostly originating from Europe (51.5%). Most records were of adults between 35 and 49 years of age (37.7%). The most involved site was the skullcap (60.4%), and the most common malignancies were metastases to the bone (65.3%) and multiple myeloma (17.4%). No primary soft tissue malignancies were registered. The results of our study indicate that head and neck cancers were present in ancient civilizations, at least since 500,000 BCE. The available data can help to improve the current understanding of the global distribution of head and neck cancer and its multidimensional impacts on populations in the contemporary world.

https://doi.org/10.1590/1807-3107bor-2024.vol38.0014

GESTÃO DA EXPERIÊNCIA DO CLIENTE: PERSPECTIVAS CONTEMPORÂNEAS NA HOTELARIA
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Oliveira, Thais Bandinelli Vargas Lopes de

; Sohn, Ana Paula Lisboa

Turismo: Visão e Ação

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Mai 2023, Volume 25 Nº 2 Páginas 358 - 381

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract: Customer experience management has been a key strategy for hotel companies considered leaders in their segments. To understand this phenomenon, we propose a systematic review aimed at identifying the practices, benefits and trends of customer experience management in the hotel industry. Conducted in the Scopus database, the research included a sample of 241 articles (time frame 2011-2021). The twenty most cited articles in the sample were accessed for analysis, and bibliometric findings from the total sample complemented the discussion. The results indicate that the main benefits are the maintenance of competitive advantage and business differentiation. Best practices are associated with human capital, use of technology, and service design. Trends point to the evolution of the concept of experience, greater attention to the employee experience, the search for mutual benefits, and the use of technology to encourage engagement and co-creation. In addition to the research agenda, this study advances by signaling the growing importance of experience management in hospitality, that its success depends on joint efforts, and that it is necessary to act actively in the face of the constant transformation of services, the economy, and consumer behavior in order to keep the hotel company competitive and aligned with the expectations of its guest.

Resumen: La gestión de la experiencia del cliente ha sido una estrategia clave para las empresas hoteleras consideradas líderes en sus segmentos. Para entender este fenómeno, proponemos una revisión sistemática destinada a identificar las prácticas, beneficios y tendencias de la gestión de la experiencia del cliente en la industria hotelera. Realizada en la base de datos Scopus, la investigación incluyó una muestra de 241 artículos (marco temporal de 2011-2021). Se accedió al contenido de los veinte artículos más citados de la muestra para su análisis y se complementó la discusión con los hallazgos bibliométricos de la muestra total. Los resultados señalan como principal beneficio el mantenimiento de la ventaja competitiva y la diferenciación empresarial. Las mejores prácticas se asocian al capital humano, el uso de la tecnología y el diseño de servicios. Las tendencias apuntan a la evolución del concepto de experiencia, una mayor atención a la experiencia del empleado, la búsqueda de beneficios mutuos y el uso de la tecnología para fomentar el compromiso y la cocreación. Además de la agenda de investigación, este estudio avanza señalando la creciente importancia de la gestión de la experiencia en la hostelería, que su éxito depende de esfuerzos conjuntos, y que es necesario actuar activamente ante la constante transformación de los servicios, la economía y el comportamiento del consumidor, para mantener la empresa hotelera competitiva y alineada con las expectativas de su huésped.

Resumo: A gestão da experiência do cliente tem sido estratégia-chave de empresas hoteleiras tidas como líderes em seus segmentos. Para entender esse fenômeno, propõe-se uma revisão sistemática visando a identificar as práticas, os benefícios e as tendências da gestão da experiência do cliente na hotelaria. Realizada na base de dados Scopus, a pesquisa contemplou uma amostra de 241 artigos (recorte temporal de 2011-2021). Os 20 artigos mais citados da amostra tiveram seu conteúdo acessado para análise e achados bibliométricos da amostra total complementaram a discussão. Os resultados assinalam como principal benefício a manutenção da vantagem competitiva e a diferenciação do negócio. Melhores práticas estão associadas ao capital humano, uso de tecnologia e design de serviço. Tendências apontam a evolução do conceito de experiência, maior atenção à experiência do colaborador, busca por benefícios mútuos e o uso da tecnologia para incentivar engajamento e cocriação. Além da agenda de pesquisa, este estudo avança ao sinalizar a crescente importância da gestão da experiência na hotelaria, que seu sucesso depende de esforços conjuntos, sendo preciso agir ativamente frente à constante transformação dos serviços, da economia e do comportamento do consumidor, a fim de manter a empresa hoteleira competitiva e alinhada às expectativas do seu hóspede.

https://doi.org/10.14210/rtva.v25n2.p359-381

Lesão Miocárdica e Prognóstico em Pacientes Hospitalizados com COVID-19 no Brasil: Resultados do Registro Nacional de COVID-19
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Barbosa, Hannah Cardoso

; Martins, Maria Auxiliadora Parreiras

; Jesus, Jordana Cristina de

; Meira, Karina Cardoso

; Passaglia, Luiz Guilherme

; Sacioto, Manuela Furtado

; Bezerra, Adriana Falangola Benjamin

; Schwarzbold, Alexandre Vargas

; Maurílio, Amanda de Oliveira

; Farace, Barbara Lopes

; Silva, Carla Thais Cândida Alves da

; Cimini, Christiane Corrêa Rodrigues

; Silveira, Daniel Vitorio

; Carazai, Daniela do Reis

; Ponce, Daniela

; Costa, Emanuel Victor Alves

; Manenti, Euler Roberto Fernandes

; Cenci, Evelin Paola de Almeida

; Bartolazzi, Frederico

; Madeira, Glícia Cristina de Castro

; Nascimento, Guilherme Fagundes

; Velloso, Isabela Vasconcellos Pires

; Batista, Joanna d’Arc Lyra

; Morais, Júlia Drumond Parreiras de

; Carvalho, Juliana da Silva Nogueira

; Ruschel, Karen Brasil

; Martins, Karina Paula Medeiros Prado

; Zandoná, Liege Barella

; Menezes, Luanna Silva Monteiro

; Kopittke, Luciane

; Castro, Luís César de

; Nasi, Luiz Antônio

; Floriani, Maiara Anschau

; Souza, Maíra Dias

; Carneiro, Marcelo

; Bicalho, Maria Aparecida Camargos

; Lima, Maria Clara Pontello Barbosa

; Godoy, Mariana Frizzo de

; Guimarães-Júnior, Milton Henriques

; Mendes, Paulo Mascarenhas

; Delfino-Pereira, Polianna

; Ribeiro, Raquel Jaqueline Eder

; Finger, Renan Goulart

; Menezes, Rochele Mosmann

; Francisco, Saionara Cristina

; Araújo, Silvia Ferreira

; Oliveira, Talita Fischer

; Oliveira, Thainara Conceição de

; Polanczyk, Carisi Anne

; Marcolino, Milena Soriano

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 Nº 2 elocation e20220151

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease’s pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients.

Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19.

https://doi.org/10.36660/abc.20220151

COVID-19 outcomes in people living with HIV: Peering through the waves
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Sales, Thaís Lorenna Souza

; Souza-Silva, Maíra Viana Rego

; Delfino-Pereira, Polianna

; Neves, João Victor Baroni

; Sacioto, Manuela Furtado

; Assis, Vivian Costa Morais de

; Duani, Helena

; Oliveira, Neimy Ramos de

; Sampaio, Natália da Cunha Severino

; Ramos, Lucas Emanuel Ferreira

; Schwarzbold, Alexandre Vargas

; Jorge, Alzira de Oliveira

; Scotton, Ana Luiza Bahia Alves

; Castro, Bruno Mateus de

; Silva, Carla Thais Cândida Alves da

; Ramos, Carolina Marques

; Anschau, Fernando

; Botoni, Fernando Antonio

; Grizende, Genna Maira Santos

; Nascimento, Guilherme Fagundes

; Ruschel, Karen Brasil

; Menezes, Luanna Silva Monteiro

; Castro, Luís César de

; Nasi, Luiz Antônio

; Carneiro, Marcelo

; Godoy, Mariana Frizzo de

; Nogueira, Matheus Carvalho Alves

; Guimarães Júnior, Milton Henriques

; Ziegelmann, Patricia Klarmann

; Almeida, Rafaela Charão de

; Francisco, Saionara Cristina

; Silveira Neto, Sidney Teodoro

; Araújo, Silvia Ferreira

; Avelino-Silva, Thiago Junqueira

; Aliberti, Márlon Juliano Romero

; Pires, Magda Carvalho

; Silva, Eduardo Sérgio da

; Marcolino, Milena Soriano

Clinics

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2023, Volume 78 elocation 100223

Resumo: En | Texto: En | PDF: En

Abstract Objective To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group.

https://doi.org/10.1016/j.clinsp.2023.100223

Preservation of immunoexpression of type I collagen, BSP and BMP4 in the dentin-pulp complex of head and neck cancer patients after radiotherapy
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FONSÊCA, Jéssica Montenegro

; MARTINS, Manoela Domingues

; VARGAS, Pablo Agustin

; SILVA, Wagner Gomes

; NORMANDO, Ana Gabriela Costa

; PALMIER, Natália Rangel

; RIBEIRO, Ana Carolina Prado

; BRANDÃO, Thaís Bianca

; LOPES, Márcio Ajudarte

; GOES, Mário Fernando de

; SANTOS-SILVA, Alan Roger

Brazilian Oral Research

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2022, Volume 36 elocation e012

Resumo: En | Texto: En | PDF: En

Abstract This study tested the hypothesis that head and neck radiotherapy (HNRT) impacts the immunoexpression of type I collagen, bone sialoprotein (BSP) and bone morphogenetic protein 4 (BMP4), thereby leading to micromorphological changes in the dentin-pulp complex (DPC), and promoting the onset and progression of radiation caries (RC). Twenty-two demineralized sections of carious teeth (a group of 11 irradiated teeth and a control group of 11 non-irradiated teeth) extracted from 19 head and neck cancer patients were analyzed by conventional optical microscopy and immunohistochemistry to investigate the micromorphology (cellular layer hierarchy, blood vessels, odontoblasts, fibroblasts, extracellular matrix, calcification, necrosis, reactionary dentin formation, and chronic inflammation), and the patterns of staining/immunolocalization of type I collagen, BSP and BMP4 in the dental pulp of irradiated and control samples. No significant differences attributable to the direct impact of radiotherapy were detected in DPC micromorphology between the groups. In addition, the patterns of immunohistochemical staining and immunolocalization of the proteins studied did not differ between the irradiated and the control samples for type I collagen, BSP or BMP4. This study rejected the hypothesis that HNRT directly damages dentition by changing the organic components and the microstructure of the DPC, ultimately leading to RC.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0012

The need for communication between clinicians and pathologists in the context of oral and maxillofacial diseases
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PÉREZ-DE-OLIVEIRA, Maria Eduarda

; HEERDEN, Willie van

; MOTTA, Ana Carolina Fragoso

; RODRIGUES-FERNANDES, Carla Isabelly

; ROMAÑACH, Mário José

; AGOSTINI, Michelle

; GUEIROS, Luiz Alcino Monteiro

; VARGAS, Pablo Agustin

; LOPES, Márcio Ajudarte

; RIBEIRO, Ana Carolina Prado

; BRANDÃO, Thaís Bianca

; ALMEIDA, Oslei Paes de

; KHURRAM, Syed Ali

; SANTOS-SILVA, Alan Roger

Brazilian Oral Research

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2022, Volume 36 elocation e008

Resumo: En | Texto: En | PDF: En

Abstract Good communication between clinicians and pathologists is a vital element in the diagnostic process, and poor communication can adversely affect patient care. There is a lack of research about communication in diagnostic oral and maxillofacial pathology. This narrative review explores different aspects of the quality of communication between clinicians and oral pathologists, with a focus on the diagnosis of oral and maxillofacial diseases. An electronic search was carried out in MEDLINE through the PubMed, Scopus, and Embase databases up to April 2021. No studies reporting communication, its adequacy or the required skills between clinicians and pathologists in oral diagnosis were found. According to studies published in medicine, strategies for improving communication skills include clinician-pathologist collaboration; a well-formatted, clear and thorough report; training in communication skills; and patient-centered care. Further studies evaluating the current practices and quality in oral and maxillofacial pathology are required to identify barriers and encourage optimal communication to facilitate diagnosis, as well as patient safety.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0008

In vitro and in vivo activity of a hypotoxic copper(I) complex against dermotropic Leishmania species
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CHAGAS, Ana Flávia da Silva

; PORCHIA, Marina

; NASCIMENTO, Thaís Pinto

; CORREA, Carolina Nunes Souza

; BRASIL, Anny Maíza Vargas

; FRANCO, Antonia Maria Ramos

Acta Amazonica

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Set 2021, Volume 51 Nº 3 Páginas 260 - 269

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A leishmaniose cutânea é uma doença causada por protozoários do gênero Leishmania e, atualmente, o tratamento de primeira escolha é o antimoniato de meglumina. Porém, devido à sua eficácia limitada e alta toxicidade, é necessário buscar novos princípios ativos para o tratamento da leishmaniose. Os complexos metálicos vêm ganhando importância devido à sua eficácia e baixa toxicidade. Nesse contexto, o presente estudo teve como objetivo avaliar a atividade leishmanicida in vitro e in vivo do complexo hipotóxico de cobre(I) [HB(pz)3]Cu(PCN). Quatro espécies dermotrópicas de Leishmania foram testadas com o complexo metálico e sua eficácia foi determinada através da viabilidade parasitária e taxa de infectividade, e a citotoxicidade foi determinada com um corante redox (resazurina). Para os testes in vivo, hamsters foram infectados e as lesões foram tratadas com uma pomada formulada contendo o complexo. A eficácia foi avaliada medindo o diâmetro do inóculo/focinho e determinando a carga parasitária. Os resultados demonstraram toxicidade moderada em macrófagos murinos e monócitos humanos e melhor eficácia em Leishmania (V.) braziliensis quando comparada às demais espécies testadas, com redução de 50% na viabilidade das formas promastigotas e amastigotas (in vitro). Os dados gerais do tratamento tópico diário por até 30 dias mostraram baixa eficácia na redução das lesões, e nenhuma cura clínica e parasitológica foi observada nos animais experimentais. Portanto, o complexo [HB(pz)3]Cu(PCN) mostrou-se promissor em estudos in vitro contra L. (V.) braziliensis, devendo ser empregado em novas formulações e novos esquemas de tratamento experimental.

ABSTRACT Cutaneous leishmaniasis is a disease caused by protozoa of the genus Leishmania and, currently, the treatment of first choice is meglumine antimoniate. However, due to its limited effectiveness and high toxicity, it is necessary to seek new active principles for leishmaniasis treatment. Metal complexes are gaining importance due to their effectiveness and low toxicity. In this context, the present study aimed to evaluate the in vitro and in vivo antileishmanial activity of the hypotoxic copper(I) complex [HB(pz)3]Cu(PCN). Four dermotropic species of Leishmania were tested with the metal complex and its effectiveness was determined through parasitic viability and infectivity rate, and cytotoxicity was determined using a redox dye (resazurin). For the in vivo tests, hamsters were infected and the lesions treated with a formulated ointment containing the complex, the effectiveness of which was assessed by measuring the diameter of the inoculum/snout location and determining the parasitic load. The results demonstrated moderate toxicity in murine macrophages and human monocytes and better efficacy in Leishmania (V.) braziliensis when compared to the other species tested, with a 50% reduction in the viability of promastigote and amastigote forms (in vitro). General data from daily topical treatment for up to 30 days showed low efficacy for reducing lesions, and no clinical and parasitological cure was observed in the experimental animals. Thus, the [HB(pz)3]Cu(PCN) complex proved to be promising in in vitro studies against L. (V.) braziliensis, and should be further tested in new formulations and new experimental treatment schemes.

https://doi.org/10.1590/1809-4392202100920 220 downloads

Contextual and individual factors associated with dental pain in adolescents from Southeastern Brazil
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MACEDO, Thaís de Faria Fonseca

; ABREU, Mauro Henrique Nogueira Guimarães de

; MARTINS, Renata de Castro

; MATTA-MACHADO, Antônio Thomaz Gonzaga da

; PINTO, Rafaela da Silveira

; CASTILHO, Lia Silva de

; VARGAS-FERREIRA, Fabiana

Brazilian Oral Research

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2021, Volume 35 elocation e111

Resumo: En | Texto: En | PDF: En

Abstract The aim of this study was to assess the factors associated with dental pain in adolescents from the state of Minas Gerais, Brazil. Individual data on adolescents aged 15 to 19 years were collected from the SB Minas survey secondary database. Dental pain over the past 6 months, assessed by a questionnaire, was used as the dependent variable. Sex, income, skin color, prevalence of untreated dental caries, periodontal health, dental treatment needs, and time of last dental appointment were analyzed as individual covariates. Allocation factor, Human Development Index (HDI), Gini coefficient, illiteracy rate, unemployment, 50% and 25% of the Brazilian monthly minimum wage, primary healthcare coverage, oral health team coverage, access to individual healthcare, and supervised toothbrushing average rate were the analyzed contextual variables. A multilevel analysis was conducted for the individual and contextual variables. Statistical analyses used hierarchical linear and nonlinear modeling to infer an association between the different levels. Male adolescents had a lower prevalence of dental pain (OR = 0.53; 95%CI = 0.37–0.75). There was an association between dental pain and low income (OR = 1.58; 95%CI = 1.07–2.33), prevalence of untreated dental caries (OR = 1.25; 95%CI = 1.11–1.40), periodontal health (OR = 1.80; 95%CI = 1.04–3.09), and dental treatment needs (OR = 6.93; 95%CI = 3.96–12.14). Sociodemographic and clinical factors at the individual level were associated with the outcome but not with contextual variables. These findings reinforce the need to address these factors for effective community health actions.

https://doi.org/10.1590/1807-3107bor-2021.vol35.0111 2 downloads

Revascularização Completa Versus Tratamento da Artéria Culpada no Infarto com Supradesnivelamento do Segmento ST: Registro Multicêntrico
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Cadore, Julia Cremona

; Furtado, Mariana Vargas

; Tumelero, Rogério Tadeu

; Tognon, Alexandre Pereira

; Krepsky, Ana Maria

; Cadore, Denis

; Ruschel, Karen Brasil

; Bedin, Julia Caldas

; Conte, Thais

; Polanczyk, Carisi Anne

Arquivos Brasileiros de Cardiologia

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Ago 2020, Volume 115 Nº 2 Páginas 229 - 237

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento São restritos os dados sobre o manejo e o prognóstico dos pacientes com infarto agudo do miocárdio com supradesnivelamento do segmento ST (IAMCSST) com acometimento multiarterial no Brasil, o que mostra a necessidade de investigar as estratégias de revascularização disponíveis. Objetivo Avaliar os desfechos relacionados à revascularização completa em comparação com o tratamento da artéria culpada em pacientes multiarteriais com IAMCSST. Métodos Foi realizada um estudo de coorte prospectiva em dois centros de hemodinâmica do Sul do Brasil, com seguimento de 1 ano após a intervenção índice. O desfecho primário foi composto de óbito cardiovascular, reinfarto ou angina recorrente e secundários acidente vascular encefálico, parada cardiorrespiratória não fatal, sangramento maior ou necessidade de reintervenção. A probabilidade de ocorrência de desfechos foi comparada entre os grupos através de regressão logística binária. Considerou-se como estatisticamente significativo o valor de probabilidade < 0,05. Resultados Participaram 85 pacientes, com média de idade de 62±12 anos, sendo 61 (71,8%) do sexo masculino. Cinquenta e oito (68,2%) pacientes receberam a estratégia de revascularização completa e 27 (31,8%), a de revascularização incompleta. A chance de ocorrência tanto do desfecho primário quanto do secundário foi significativamente maior entre os indivíduos tratados com revascularização incompleta quando comparados com os tratados com estratégia completa [razão de chances (OR) 5,1, intervalo de confiança de 95% (IC95%) 1,6-16,1 vs. OR 5,2, IC95% 1,2-22,9, respectivamente], assim como os óbitos cardiovasculares (OR 6,4, IC95% 1,2-35,3). Conclusão Dados deste registro regional, de dois centros do Sul do Brasil, demonstram que a estratégia de revascularização completa esteve associada à redução significativa dos desfechos primário e secundário no seguimento de 1 ano quando comparada à estratégia de revascularização incompleta. (Arq Bras Cardiol. 2020; 115(2):229-237)

Abstract Background Data on the management and prognosis of patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease are limited in Brazil, showing that the available revascularization strategies should be investigated Objective To assess the outcomes of complete revascularization versus treatment of the culprit artery only in patients with STEMI and multivessel disease. Methods A prospective cohort study was conducted at two medical centers in southern Brazil with a 1-year follow-up after the index procedure. The primary outcome was a composite of cardiac death, reinfarction, or recurrent angina, while the secondary outcome was stroke, nonfatal cardiac arrest, major bleeding, or need for reintervention. The probability of outcomes occurring was compared between the groups using binary logistic regression. A p-value < 0.05 was considered statistically significant. Results Eighty-five patients were included. Their mean age was 62±12 years, and 61 (71.8%) were male. Fifty-eight (68.2%) were treated with complete revascularization and 27 (31.8%) with incomplete revascularization. The chance of both the primary and secondary outcomes occurring was significantly greater among patients treated with incomplete revascularization when compared to those treated with complete revascularization (odds ratio [OR] 5.1, 95% confidence interval [CI] 1.6-16.1 vs. OR 5.2, 95% CI 1.2-22.9, respectively), as well as cardiac death (OR 6.4, 95% CI 1.2-35.3). Conclusion Registry data from two centers in southern Brazil demonstrate that the complete revascularization strategy is associated with a significant reduction in primary and secondary outcomes in a 1-year follow-up when compared to the incomplete revascularization strategy (Arq Bras Cardiol. 2020; 115(2):229-237)

https://doi.org/10.36660/abc.20180346 1006 downloads

10.

Is possible to rule out clinically significant prostate cancer using PI-RADS v2 for the assessment of prostate MRI?
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Viana, Publio Cesar Cavalcanti

; Horvat, Natally

; Santos Júnior, Valter Ribeiro dos

; Lima, Thais Carneiro

; Romão, Davi dos Santos

; Cerri, Luciana Mendes de Oliveira

; Castro, Marilia Germanos de

; Vargas, Herbert Alberto

; Miranda, Júlia Azevedo

; Leite, Claudia da Costa

; Cerri, Giovanni Guido

International braz j urol

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Ago 2019, Volume 45 Nº 4 Páginas 724 - 731

Resumo: En | Texto: En | PDF: En

ABSTRACT Objectives To evaluate the diagnostic performance and interobserver agreement of PI-RADS v2. Materials and Methods In this Institutional Review Board approved single-center retrospective study, 98 patients with clinically suspected PCa who underwent 3-T multiparametric MRI followed by MRI/TRUS fusion-guided prostate biopsy were included from June 2013 to February 2015. Two radiologists (R1 and R2) with 8 and 1 years of experience in abdominal radiology reviewed the MRI scans and assigned PI-RADS v2 scores in all prostate zones. PI-RADS v2 were compared to MRI/TRUS fusion-guided biopsy results, which were classified as negative, PCa, and significant PCa (sPCa). Results Sensitivity, specificity, NPV, PPV and accuracy for PCa was 85.7% (same for all metrics) for R1 and 81.6%, 79.6%, 81.2%, 80.0% and 80.6% for R2. For detecting sPCa, the corresponding values were 95.3%, 85.4%, 95.9%, 83.7% and 89.8% for R1 and 93.0%, 81.8%, 93.7%, 86.7% and 86.7% for R2. There was substantial interobserver agreement in assigning PI-RADS v2 score as negative (1, 2, 3) or positive (4, 5) (Kappa=0.78). On multivariate analysis, PI-RADS v2 (p <0.001) was the only independent predictor of sPCa compared with age, abnormal DRE, prostate volume, PSA and PSA density. Conclusions Our study population demonstrated that PI-RADS v2 had high diagnostic accuracy, substantial interobserver agreement, and it was the only independent predictor of sPCa.

https://doi.org/10.1590/s1677-5538.ibju.2018.0382 1444 downloads

11.

Motivos para a prática de atividade física de esportes orientados à habilidade: um exemplo do taekwondo
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Faria, Larissa Oliveira

; Ribeiro, Thiago Lopes

; Souza, Thais Frois de

; Rennó, Giovanna Vargas Consoli

; Albuquerque, Maicon Rodrigues

Revista Brasileira de Ciências do Esporte

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Jun 2019, Volume 41 Nº 2 Páginas 198 - 205

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo O presente estudo objetiva identificar os motivos que levam à pratica do taekwondo, bem como verificar possíveis diferenças entre praticantes faixas iniciais e faixas pretas. A versão brasileira da escala Motivos para a Prática de Atividade Física‐Revisada (MPAM‐R) foi usada. Os testes de Friedman e de Mann‐Whitney com correção de Bonferroni foram usados nas análises estatísticas. Os resultados mostraram que “competência”, “diversão” e “social” são os principais motivos para a prática do taekwondo, mas que os motivos para a prática não diferem entre faixas iniciais e faixas pretas. Conclui‐se que tanto praticantes iniciantes quanto praticantes experientes de taekwondo são intrinsecamente motivados.

Abstract The present study aims to identify the motives that lead to the practice of taekwondo, as well as to verify possible differences between practitioners and black belts. The Brazilian version of Motives for Physical Activity Measure Revise (MPAM‐R) was used. The Friedman test and the Mann‐Whitney test with Bonferroni correction were used in the statistical analysis. The results show that “competence,” “enjoyment” and, “social” are the main reasons for taekwondo practice, but that the motives for practice did not differ between beginners and black belts. Thus, both novice and experienced taekwondo practitioners are intrinsically motivated.

Resumen El presente estudio tiene como objetivo identificar los motivos que conducen a la práctica del taekwondo, así como comprobar las posibles diferencias entre los taekwondistas principiantes y los cinturones negros. Se utilizó la versión brasileña de Motives for Physical Activity Measure Revise (MPAM‐R). La prueba de Friedman y la prueba de Mann‐Whitney con la corrección de Bonferroni se utilizaron en los análisis estadísticos. Los resultados muestran que «competencia», «disfrute» y «social» son los principales motivos para la práctica del taekwondo y estos no difieren entre principiantes y cinturones negros. Por tanto, tanto los taekwondistas principiantes como los experimentados están intrínsecamente motivados.

https://doi.org/10.1016/j.rbce.2018.10.004 1240 downloads

12.

PREDIÇÃO E CONSCIÊNCIA LINGUÍSTICA NA LEITURA DE CRÔNICA EM TECNOLOGIA VIRTUAL E TECNOLOGIA NÃO VIRTUAL
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Wannmacher Pereira, Vera

; Vargas dos Santos, Thaís

Lingüística y Literatura

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Dez 2017, Nº 72 Páginas 13 - 29

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract: This article presents a reported study that examined the contribution of materials on virtual and non-virtual technologies with a focus on linguistic awareness in chronicles prediction reading to students in the 9th grade of high school. The Psycholinguistics was the theoretical support and Computer(s) the technical support. It involved materials production and the use of workshops development and use of pre-test and post-test. The results indicated a significant difference pre/post-tests in the awareness of the prediction use, and a favorable advantage of virtual technology, although with no statistically significant difference. The goal achievement, recommending the material use, at school, with the proprieties examined.

Resumo: Neste artigo, é relatado estudo que examinou a contribuição de materiais em tecnologias virtual e não virtual com foco na consciência linguística no uso da predição leitora de crônica, para alunos do 9º ano. A Psicolinguística foi o suporte teórico e a Computação, o apoio técnico. Envolveu produção de materiais, desenvolvimento de oficinas de leitura e uso de pré e pós-teste. Os resultados indicaram diferença significativa pré/pós-teste na consciência sobre uso da predição, vantagem favorável à tecnologia virtual, embora sem diferença estatística significativa, e alcance do objetivo estabelecido, recomendando o uso, na escola, de materiais com as propriedades estudadas.

https://doi.org/10.17533/udea.lyl.n72a01 341 downloads

13.

A prototype single-port device for pressurized intraperitoneal aerosol chemotherapy. Technical feasibility and local drug distribution
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Seitenfus, Rafael

; Ferreira, Paulo Roberto Walter

; Santos, Gabriel Oliveira dos

; Alves, Rafael José Vargas

; Kalil, Antonio Nocchi

; Barros, Eduardo Dipp de

; Glehen, Olivier

; Casagrande, Thaís Andrade Costa

; Bonin, Eduardo Aimoré

; Silva Junior, Edison Martins da

Acta Cirúrgica Brasileira

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Dez 2017, Volume 32 Nº 12 Páginas 1056 - 1063

Resumo: En | Texto: En | PDF: En

Abstract Purpose: To evaluate the technical feasibility and homogeneity of drug distribution of pressurized intraperitoneal aerosol chemotherapy (PIPAC) based on a novel process of intraperitoneal drug application (multidirectional aerosolization). Methods: This was an in vivo experimental study in pigs. A single-port device was manufactured at the smallest diameter possible for multidirectional aerosolization of the chemotherapeutic drug under positive intraperitoneal pressure. Four domestic pigs were used in the study, one control animal that received multidirectional microjets of 9 mL/sec for 30 min and three animals that received multidirectional aerosolization (pig 02: 9 mL/sec for 30 min; pigs 03 and 04: 3 mL/sec for 15 min). Aerosolized silver nitrate solution was applied for anatomopathological evaluation of intraperitoneal drug distribution. Results: Injection time was able to maintain the pneumoperitoneum pressure below 20 mmHg. The rate of moderate silver nitrate staining was 45.4% for pig 01, 36.3% for pig 02, 36.3% for pig 03, and 72.7% for pig 04. Conclusions: Intra-abdominal drug distribution had a broad pattern, especially in animals exposed to the drug for 30 min. Our sample of only four animals was not large enough to demonstrate an association between aerosolization and a higher silver nitrate concentration in the stained abdominal regions.

https://doi.org/10.1590/s0102-865020170120000007 1040 downloads

14.

ESTRATÉGIA DE LEITURA DE PREDIÇÃO NA ESCOLA: USO E CONSCIÊNCIA LINGUÍSTICA NO SEU USO
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Pereira, Vera Wannmacher

; Santos, Thais Vargas dos

Linguagem em (Dis)curso

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Dez 2017, Volume 17 Nº 3 Páginas 361 - 380

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Neste artigo é relatado estudo que examinou a contribuição, para alunos do 9º ano do Ensino Fundamental, de materiais virtuais (informatizados) e não virtuais (impressos) com foco no uso da estratégia de leitura de predição e na consciência linguística de seu uso, utilizando o conto como texto. Teve como suporte teórico a Psicolinguística, especialmente em relação a esses dois tópicos centrais, e utilizou o apoio de tecnologias. Envolveu produção dos materiais e sua aplicação em oficinas na escola selecionada, elaboração e aplicação de testes antes e após as oficinas, assim como preparação continuada dos alunos bolsistas e professores. Os resultados indicaram diferença significativa na relação pré/pós-teste no uso da predição e na consciência sobre seu uso; e na comparação entre as tecnologias, vantagem favorável à virtual, embora sem diferença estatística significativa. Como conclusão, cabe afirmar o alcance do objetivo e recomendar trabalho na escola com materiais com as propriedades estudadas.

Abstract In this article, we report a study that examined the contribution, for students of the 9th grade of Elementary School, of virtual and non-virtual materials with focus on the use of the prediction reading strategy and on the linguistic awareness of its use, using short story as text. Theoretically based on Psycholinguistics, especially regarding to these two central topics, it also used technologies as support. It involved production of materials and its application on workshops at the school chosen, elaboration and applications of tests before and after the workshops, as well as the continuous preparation of the scholarships teachers and students. The results indicated significant difference in the pre and post-test relationship on the use of the prediction strategy and on the awareness about its use; and on the comparison between the technologies, a favorable advantage to virtual one, although without statistically significant difference. As a conclusion, we can affirm that the research objective was achieved, recommending teaching in school with materials including the properties studied.

Resumen En este artículo, se relata un estudio que examinó la contribución, para alumnos del 9º año de la Enseñanza Primaria, de materiales virtuales y no virtuales con enfoque en el uso de la estrategia de predicción lectora y en la conciencia lingüística de su uso, utilizando el cuento como género textual. Tuvo como soporte teórico la Psicolingüística, especialmente en relación con estos dos temas centrales, y utilizó el apoyo de tecnologías. Envolvió producción de los materiales y su aplicación en talleres en la escuela elegida, elaboración y aplicación de instrumentos antes (pre prueba) y después (post prueba) de los talleres, así como preparación continuada de los alumnos becarios y profesores. Los resultados indicaron diferencia significativa en la relación entre pre y postprueba en el uso de la predicción y en la conciencia sobre su uso; y, en la comparación entre las tecnologías, ventaja favorable a la virtual, aunque sin diferencia estadística significativa. Como conclusión, cabe afirmar el logro del objetivo y recomendar el trabajo en la escuela con materiales con las propiedades estudiadas.

https://doi.org/10.1590/1982-4017-170305-2117 2358 downloads

15.

Electrodeposition of Composite Coatings of Cu/AlO(OH) Using Allyl Alcohol as an Additive
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Rezende, Thaís Guimarães de Lima

; Lago, Dalva Cristina Baptista do

; Cesar, Deborah Vargas

; Senna, Lilian Ferreira de

Materials Research

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2017, Volume 20 Páginas 374 - 385

Resumo: En | Texto: En | PDF: En

In this work, composite coatings of Cu/AlO(OH) were produced by electrodeposition on steel substrates using a pyrophosphate-based bath containing allyl alcohol as an additive. The electrodeposition of the composite coatings was carried out using a 23 central composite design (CCD), aiming to verify the effects of the deposition parameters (previous stirring time (t), the stirring speed (S) and the current density (j)), considered the entry variables, on the electrochemical behavior of Cu/AlO(OH) coating, the response variables of the CCD. The results indicated that a decrease of the parameters j and S directly influenced the values of Rp and Rct, leading to the production of protective coatings. The best result (Rp = 211 Ω and Rct = 221 Ω) was obtained under conditions where t = 120 min, S = 1300 rpm and j = 7 A m-2. Dispersed bohemite particles could be noted on the surface of the composite coating.

https://doi.org/10.1590/1980-5373-mr-2016-0995 648 downloads

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