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Abstract The research was performed in the cycle 2020, with the objective of determining the chemical characteristics of the soil and water quality in the municipalities of Miahuatlán de Porfirio Díaz and Ejutla de Crespo, Oaxaca, Mexico. The soil and water were sampled, the content of cations, anions and water quality variables were determined. High concentrations of Ca and Mg were recorded in the soil with average values of up to 19.20 and 19.42 mEq L-1 respectively. High concentrations of Ca2+, Mg2+ and HCO3 - were recorded in the water with average values of up to 4.79, 4.32 and 7.97 mEq L-1 respectively. According to the variables SP, RAS, IS and CSR, the water is classified as suitable for irrigation. It is concluded that the use of acids is necessary to lower the pH of the water and neutralize the carbonates.

Resumen La investigación se realizó en el ciclo 2020, con el objetivo de determinar las características químicas del suelo y calidad del agua en los municipios de Miahuatlán de Porfirio Díaz y Ejutla de Crespo, Oaxaca, México. Se muestreo el suelo y agua, se determinó contenido de cationes, aniones y variables de calidad del agua. En el suelo se registró alta concentración de Ca2+ y Mg2+ con valores promedio de hasta 19.20 y 19.42 mEq L-1 respectivamente. En el agua se registró alta concentración de Ca2+, Mg2+ y HCO3 - con valores promedio de hasta 4.79, 4.32 y 7.97 mEq L-1 respectivamente. Según las variables SP, RAS, IS y CSR el agua se clasifica como adecuada para riego. Se concluye que el uso de ácidos es necesario para bajar el pH del agua y neutralizar los carbonatos.

https://doi.org/10.19136/era.a11n1.3948

Computational Insight and Anticancer Effect of Cinnamic Acid-Derivative Amide Compounds AcidDerivative Acid Derivative
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Alarcón-López, Aldo Y.

; Hernández-Serda, Manuel A.

; Aguirre-Vidal, Pablo

; Cárdenas-Granados, Luis A.

; Vázquez-Valadez, Víctor H.

; Martínez-Soriano, Pablo A.

; Briseño-Lugo, Paola

; Velázquez-Sánchez, Ana M.

; Rul-Ramírez, Elizabeth

; Jiménez-Jiménez, María Luisa

; Becerril-Ricco, Jared

; Guevara, Alhel Adán-Ladrón de

; Tinajero-Rodríguez, José Manuel

; Ortiz, Elizabeth

; Ángeles, Enrique

Journal of the Brazilian Chemical Society

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2024, Volume 35 Nº 6 elocation e-20230195

Resumo: En | Texto: En | PDF: En

In this research, a meticulous screening process was conducted using four servers: Drug Target Explorer, Swiss Target Predictor, SEA Predictor, and Target Hunter. The primary objective was to identify a series of potential biological targets related to the regulation of cell growth and apoptosis in cancer cells using cinnamic acid derivatives. This study focused on five specific targets, matrix metallopeptidase 9 (MMP9), apoptosis inducing factor (AIF), aldo-keto reductase family 1 member C3 (AKR1C3), aldo-keto reductase family 1 member B10 (AKR1B10), mitogen-activated protein kinase 14 (MAPK14), all of which are well known to play a significant role in cancer cell dynamics. To explore both molecular recognition and molecular dynamics, a series of in silico investigations (docking and molecular dynamics) were carried out using a collection of 14 cinnamic acid derivatives, including cinnamic acid phenethyl ester (CAPE) as a notable reference molecule due to its widely recognized anticancer effects. Furthermore, preliminary in vitro data revealed a potentially promising cytotoxic effect of (E)-N-[(3,4-dichlorophenyl)methyl]-3-(4-phenoxyphenyl)-2-propenamide (LQM755) on a human gastric adenocarcinoma cell-line (AGS cells), which are characterized by the overexpression of the MMP9 protein. Therefore, the chemical compound LQM755 provides an initial perspective in the field of cancer therapy. research servers Explorer Predictor Hunter derivatives MMP9, MMP , (MMP9) AIF, AIF (AIF) aldoketo aldo keto C AKR1C3, AKR1C3 AKRC AKR (AKR1C3) B B1 AKR1B10, AKR1B10 AKRB (AKR1B10) mitogenactivated mitogen activated MAPK14, MAPK14 MAPK (MAPK14) dynamics docking CAPE (CAPE effects Furthermore EN3,4dichlorophenylmethyl34phenoxyphenyl2propenamide EN34dichlorophenylmethyl34phenoxyphenyl2propenamide ENdichlorophenylmethylphenoxyphenylpropenamide E N 3,4 dichlorophenyl methyl 3 4 phenoxyphenyl 2 propenamide LQM (LQM755 cellline line AGS cells, cells) Therefore LQM75 therapy (MMP9 (AIF AKR1C (AKR1C3 AKR1B1 (AKR1B10 MAPK1 (MAPK14 EN3 4dichlorophenylmethyl34phenoxyphenyl2propenamide EN dichlorophenylmethyl 34 3, (LQM75 LQM7 (MMP (AKR1C AKR1B (AKR1B1 (MAPK1 dichlorophenylmethylphenoxyphenylpropenamide (LQM7 (AKR1B (MAPK (LQM

https://doi.org/10.21577/0103-5053.20230195

Development of an Optimized Induction Melting System for Fabricating Paraffin Fuel Grains for Hybrid Rocket Propulsion
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Martínez, José Refugio

; Cruz-Mendoza, José Ángel de la

; Vázquez-Martínez, Emmanuel

; Cruz, Daniel Romero de la

; Guerrero, Azdrubal Lobo

; Saucedo-Zárate, Gerardo

; Arauz-Lara, José Luis

; González-Aguilar, Hernán

; Ortega-Zarzosa, Gerardo

Journal of Aerospace Technology and Management

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2024, Volume 16 elocation e3024

Resumo: En | Texto: En | PDF: En

ABSTRACT This work reports the development of an induction melting system for producing paraffin-based fuel units for hybrid rockets. The system is based in oscillating low-frequency magnetic field to generate heat within the material, enabling a precise temperature control through an on/off process. Additionally, the steel used as the material for fabricating the mold facilitates a slow cooling rate, leading to the formation of homogeneous paraffin fuel units free from cracks and microfractures, which is a critical requirement for their safe application in hybrid rockets and to ensure an efficient fuel combustion. The fabricated paraffin fuel units underwent rigorous characterization of their thermal, structural, and optical properties to ensure their suitability as fuel units in a hybrid rocket engine developed for the Mexican Cabo Tuna space program. paraffinbased lowfrequency low frequency onoff on off process Additionally rate microfractures combustion thermal structural program

https://doi.org/10.1590/jatm.v16.1350

Dinámica del pastoreo en la asociación cultivos y ovinos de agroecosistemas de clima templado en México
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Vargas López, Samuel

; Bustamante González, Angel

; Jaramillo Villanueva, José Luis

; Vázquez Martínez, Ignacio

; Vaquera Huerta, Humberto

; Díaz Sánchez, Carla Cristina

; Casiano Ventura, Miguel Ángel

Revista mexicana de ciencias pecuarias

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Set 2023, Volume 14 Nº 3 Páginas 572 - 591

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen En el presente estudio se analizó la dinámica del pastoreo en la producción de ovinos asociada a los cultivos agrícolas a partir de la dimensión social, productiva, mercado, ingresos y ambiental en la región templada de Puebla y Tlaxcala, México. Se registró el uso del pastoreo, relieve, clima, cultivos y tipo de vegetación en los sistemas de producción y datos de la familia, medios de producción, mercado e ingresos con entrevista a 256 productores de ovinos. Los datos se analizaron con estadística descriptiva y modelos de regresión lineal de superficie de respuesta y modelos multinivel, con el paquete estadístico SAS. Como resultados se definieron cinco asociaciones cultivos y ovinos. Los modelos de regresión lineal de superficie de respuesta, ajustada por porcentaje de pastoreo, tuvieron diferencias en las pendientes estimadas (P<0.05) para experiencia del productor, escolaridad, jornales dedicados a ovinos, valor de instalaciones y tamaño de rebaño. El análisis multinivel mostró que 19 % de la varianza en el tiempo de pastoreo (horas) fue explicada por las variables de las asociaciones cultivos y ovinos (nivel 2) y el resto por las unidades de producción (nivel 1). Los modelos multinivel asociaron el tiempo de pastoreo con los ingresos (P<0.01), porcentaje de venta de corderos (P<0.01), escolaridad (P<0.05), jornales dedicados a ovinos (P<0.05), tamaño de rebaño P<0.05) y porcentaje de pastoreo (P<0.001). El estudio permitió clasificar a los agroecosistemas e identificar el perfil del productor más apropiado para la producción de ovinos en el contexto socioecológico y económico en la región templada de Puebla y Tlaxcala, México.

Abstract The study analyzed the dynamics of grazing in sheep production associated with agricultural crops based on the social, productive, market, income, and environmental dimensions in the temperate region of Puebla and Tlaxcala, Mexico. The use of grazing, topography, climate, crops and type of vegetation in the production systems and data on the family, means of production, market and income were recorded with interviews applied to 256 sheep producers. Data were analyzed with descriptive statistics and response surface linear regression models and multilevel models, with the SAS statistical package. Five crop and sheep associations were defined as results. The response surface linear regression models, fitted for grazing percentage, had differences in the slopes estimated (P<0.05) for producer experience, schooling, days of work spent on sheep, value of facilities and flock size. The multilevel analysis showed that 19 % of the variance in grazing time (hours) was explained by the variables of crop and sheep associations (level 2) and the rest by production units (level 1). Multilevel models associated grazing time with income (P<0.01), percentage of lamb sales (P<0.01), schooling (P<0.05), days of work spent on sheep (P<0.05), flock size P<0.05) and grazing percentage (P<0.001). The study allowed the classification of agroecosystems and the identification of the most appropriate profile of producer for sheep production in the socioecological and economic context in the temperate region of Puebla and Tlaxcala, Mexico.

https://doi.org/10.22319/rmcp.v14i3.6288

Guía de práctica clínica para el manejo del cáncer de pulmón de células pequeñas: enfermedad extensa
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Cabrera-Miranda, Luis A.

; Díaz-García, Diego A.

; Corona-Cruz, José F.

; Lozano-Ruiz, Francisco J.

; Sánchez-Reyes, Roberto

; Álvarez-Bojórquez, Mario E.

; Blake-Cerda, Mónika

; Rivera-Márquez, Raúl

; López-Saucedo, Raúl A.

; Pérez-Álvarez, Sandra I.

; Bolaño-Guerra, Laura M.

; Alatorre-Alexander, Jorge A.

; Alexander-Meza, Francisco

; Barrón-Barrón, Feliciano

; Blanco-Vázquez, Yazmín C.

; Campos-Gómez, Saúl

; Mata-Moya, Dolores de la

; Figueroa-Martínez, Pedro

; González-Cisneros, Paulina E.

; Íñiguez-García, Marco A.

; Lázaro-León, Jesús M.

; Loyola-García, Ulises

; Morales-Rivera, Marcelino

; Olivares-Torres, Carlos

; Ramos-Ramírez, Maritza

; Sáenz-Frías, Julia A.

; Silva-Bravo, Fernando

; Trejo-Rosales, Rogelio

; Souto-del Bosque, Miguel

; Arrieta, Óscar

Gaceta mexicana de oncología

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Jun 2023, Volume 22 Nº 2 Páginas 55 - 73

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Antecedentes: El cáncer de células pequeñas (CPCP) representa el 13-15% del total de neoplasias primarias de pulmón. Se caracteriza por su rapidez en la tasa de crecimiento y en el desarrollo de metástasis a distancia. Objetivos: Orientar y estandarizar el tratamiento del CPCP enfermedad extensa en México basado en evidencia clínica nacional e internacional. Material y métodos: Este documento se desarrolló como una colaboración del Instituto Nacional de Cancerología y la Sociedad Mexicana de Oncología en cumplimiento con estándares internacionales. Se integró un grupo conformado por oncólogos médicos, cirujanos oncólogos, cirujanos de tórax, radio-oncólogos y metodólogos con experiencia en revisiones sistemáticas de la literatura y guías de práctica clínica. Resultados: Se consensaron, por el método Delphi y en reuniones a distancia, las recomendaciones en CPCP enfermedad extensa, producto de preguntas de trabajo. Se identificó y evaluó la evidencia científica que responde a cada una de dichas preguntas clínicas antes de incorporarla al cuerpo de la guía. Conclusión: Esta guía proporciona recomendaciones clínicas para el manejo de la enfermedad extensa del CPCP y durante el proceso de toma de decisiones de los clínicos involucrados con su manejo en nuestro país para mejorar la calidad de la atención clínica para estos pacientes.

Abstract Background: Small cell lung cancer (SCLC) represents 13-15% of all primary lung neoplasms and is characterized by its rapid growth rate and the rapid development of distant metastases. Objectives: To guide and standardize the treatment of extensive disease small cell lung cancer in Mexico based on national and international clinical evidence. Material and methods: This document was developed as a collaboration between the National Cancer Institute and the Mexican Society of Oncology in compliance with international standards. An interdisciplinary group was formed, including medical oncologists, oncological surgeons, thoracic surgeons, radiation oncologists, and methodologists with experience in systematic reviews of the literature and clinical practice guidelines. Results: A consensus was reached, both by the Delphi method and in remote meetings, of extensive disease recommendations resulting from work questions. The scientific evidence that answers each of these clinical questions was identified and critically evaluated, before being incorporated into the body of evidence of the Guide. Conclusions: This Clinical Practice Guide provides clinical recommendations for the management of extensive disease of SCLC to contribute to the decision-making process of the clinicians involved with its management in our country, hoping that this will contribute to improving the quality of clinical care in these patients.

https://doi.org/10.24875/j.gamo.22000122

Morphochemical characterization of Chlamydomonas during its blooming in a Mexican urban lake
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Godínez-Ortega, José Luis

; Peralta-Soriano, Laura

; Lugo-Vázquez, Alfonso

; Escobar-Oliva, Marco Antonio

; Sánchez-Rodríguez, María del Rosario

; Oliva-Martínez, María Guadalupe

Hidrobiológica

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Abr 2023, Volume 33 Nº 1 Páginas 1 - 14

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Antecedentes: Los florecimientos algales han aumentado en frecuencia e intensidad en las últimas décadas. El exceso de nutrientes de origen antropogénico puede ser un factor esencial. Objetivos: Este trabajo tuvo como objetivo estudiar un florecimiento inusual de la clorofita Chlamydomonas en un lago urbano desde un enfoque morfológico y químico. Métodos: El sitio de estudio fue un pequeño lago somero ubicado en la Cantera Oriente, Ciudad de México. El muestreo se realizó en febrero de 2016 (época fría-seca); las variables ambientales se midieron in situ y se obtuvieron muestras de superficie para determinar la abundancia de organismos y la concentración de clorofila-a. Una muestra adicional se liofilizó para análisis químicos y otra muestra se fijó en glutaraldehído para estudios ultraestructurales mediante MEB, MET, ML y microscopía confocal, utilizando la tinción de rojo Nilo para detectar la presencia de lípidos intracelulares. Resultados: Los resultados de las observaciones morfológicas coincidieron con las características de la descripción de C. reinhardtii. Los valores de abundancia del florecimiento fueron altos (6.98 x 105 ± 1.37 x 105 células mL-1), lo cual se asocia con los altos valores de concentración de clorofila-a (5548 ± 796 µg L-1). La proporción de carbohidratos: proteínas de las células (0.15) indica una alta síntesis de proteínas durante la enorme proliferación de algas. El bajo contenido de lípidos (6.5 %) está asociado a la ausencia de gránulos de lípidos intracelulares, posiblemente vinculado con la disponibilidad de nitrógeno y fósforo y a la alta multiplicación vegetativa. C. reinhardtii sintetiza ácidos grasos esenciales, como el ácido alfa-linolénico (Omega 3), un importante precursor de lípidos beneficiosos para la salud cardiovascular y neurológica humana. Conclusiones: Se concluye que el florecimiento estuvo constituido principalmente por C. reinhardtii, lo que se correlacionó significativamente con la abundancia y concentración de clorofila, indicando alta capacidad fotosintética y división celular activa. Se encontró la presencia en las algas del ácido linoléico (Omega 3), de importancia en la salud humana, que podría aumentar su concentración en un cultivo controlado y así ofrecer un recurso biotecnológico en el futuro.

Abstract Background: Algal blooms have increased in frequency and intensity in recent decades. Excess nutrients of anthropogenic origin may be an essential factor that gives rise to these blooms. Goals: This work aimed to study an unusual bloom of the chlorophyte Chlamydomonas in an urban lake from a morphological and chemical approach. Methods: The study site was a small lake located in Cantera Oriente, Mexico City. Sampling was performed in February 2016 (the cold-dry season); environmental variables were measured in situ, and surface samples were obtained for organism abundance and chlorophyll-a concentration. An additional sample was freeze-dried for chemical analyses, and another sample was fixed in glutaraldehyde for ultrastructural studies by SEM, TEM, LM, and confocal microscopy, using the stain Nile red to detect the presence of intracellular lipids. Results: The results of morphological observations agreed with the characteristics of the description of C. reinhardtii. The bloom abundance values were high (6.98 x 105 ± 1.37 x 105 cells mL-1), confirmed by the high values of chlorophyll-a concentration (5548 ± 796 µg L-1). The carbohydrate:protein ratio of the cells (0.15) indicates high protein synthesis during the enormous algal proliferation. The low lipid content (6.5 %) is associated with the absence of intracellular lipid granules and may be related to the availability of nitrogen and phosphorus and high vegetative multiplication. C. reinhardtii synthesizes essential fatty acids, such as alpha-linolenic acid (Omega 3), a precursor of beneficial lipids in human cardiovascular and neurological health. Conclusions: The bloom consisted mainly of Chlamydomonas reinhardtii and it significantly correlated with the chlorophyll a concentration, indicating high photosynthetic capacity and active cell division. Linoleic acid (Omega 3), an important substance for human health, was present in the alga composition. A controlled culture of this alga could improve the Omega 3 concentration offering a biotechnological resource for the future.

https://doi.org/10.24275/uam/izt/dcbs/hidro/2023v33n1/godinez

Code infarction initiative of Bajio region, during the pandemic by COVID-19 in a reconversion hospital
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Villar-Valencia, Cristian Adrián

; Hernández-González, Martha Alicia

; Borrayo-Sánchez, Gabriela

; Celis-Quintal, Juan German

; Solorio-Meza, Sergio Eduardo

; Medina-Torres, Oscar Samuel

; Gutiérrez-Galván, Maraí Xochitl

; Rodríguez-Martínez, Braulio

; Prado-Rodríguez, Luis Humberto

; Vázquez-Morones, Ana Laura

; Alatoma-Medina, Juan Pablo

; Hernández-Estala, Jorge

; Patiño-Amaya, Aristóteles

; Magdaleno-Serrano, Hugo Ivan

; Rodríguez-Déniz, Carmen

; Arellano-Sotelo, Hugo

; Nava-Hernández, Guillermo

; Ramírez-Vázquez, Ricardo

; Chimal-Flores, Marco Antonio

; Alegría-Peredia, Emiliano

; Ramos-González, Gerardo Rubén

; Pérez-Benítez, Rigoberto

; Bermúdez-Acévez, Erik

; Valencia-Martínez, Hypatia

; Segovia-Solís, Hugo

; López-Varela, Manuel

; Monroy-Córdoba, Doryan

; Marmolejo-López, Adriana

; Báez-Montes, Alfredo

; Hernández-Cerqueda, Fabián

; Nolasco-Muñoz, Luis Ricardo

; Vargas-Ramírez, Luis Manuel

; Celis-Quintal, Juan German

; Bernal-Ruíz, Enrique Alfredo

; Delgado-Sánchez, Anabella

; Sánchez-López, José Manuel

; Bautista-López, Germán Ramón

; Acevedo-Gómez, Pablo Francisco

; Acuña-Valerio, Jorge Francisco

; González-Ortíz, Oracio

; Hernández-Padilla, Adolfo Asahel

; Solórzano-Vázquez, Marco Alejandro

; Franco-Herrera, Noel

; González, Luis Jonathan

; Reyes-Álvarez, José Miguel

; Salinas-Cavazos, Iván Rosendo

; Tiscareño-Villanueva, Ashby Daniel

; Vidrio-Villaseñor, Ramiro

; Fernández-Yáñez, Gabriel

; Meza, Ma. Guadalupe

; Nucamendi-Solórzano, Freeman Issac

; Sandoval-Uribe, José de Jesús

; Sotelo-García, Luis David

; Zamoaya-Paz, Luis Carlos

; Espriu, Donovan Fernando

; García-Rodríguez, Román

; López-Ibarra, Daniel Eugenio

; López-Valencia, Andrea Janeth

; Villar-Valencia, Cristian Adrián

; Navarro-Pérez-Macedo, Javier

Cardiovascular and metabolic science

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Set 2022, Volume 33 Nº 3 Páginas 97 - 105

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract: Introduction: Acute myocardial infarction has a high prevalence and possibility of death if timely care is not given. It is possible that treatment could be delayed during a health crisis such as the COVID-19 pandemic. Objective: The objective of this study was to evaluate the impact of the COVID-19 pandemic on the function of the infarction code in the High Specialty Medical Unit of our institution. The medical indicators of acute coronary ischemic syndrome with ST-segment elevation were compared at two times: before the COVID-19 pandemic and during it. Material and methods: An ambispective, analytical, comparative cohort study was conducted, comparing the periods of February-September 2019 and February-September 2020, in the High Specialty Medical Unit, Centro Médico del Bajío number 1, Instituto Mexicano del Seguro Social, Leon, Guanajuato, Mexico. All patients older than 18 years with clinical, electrocardiographic, and enzymatic data of acute coronary ischemic syndrome, accepted in the medical network as infarction code registered in the National Registry of Acute Coronary Ischemic Syndromes (RENASCA) electronic case report form were included in the study. Results: The independent samples t-test was used to determine the impact of the infarction code initiative based on the reperfusion therapies performed, the door-to-needle, the door-to-balloon time, and the ischemia time. There was a significant difference in the reperfusion strategy, with greater thrombolysis during the COVID-19 pandemic (57.4% versus 72.6%, odds ratio [OR] 1.97, 95% confidence interval [CI] 0.49-0.82, p < 0.001), as well as reperfusion criteria (21.03% versus 35.37%, OR 2.05, 95% CI 0.53-0.80, p < 0.0001). Mortality was not different between the time periods. Conclusions: The COVID-19 pandemic has not impacted operation of the infarction code in the High Specialty Medical Unit Centro Médico del Bajío number 1 because the medical indicators of acute coronary ischemic syndrome with ST-segment elevation did not change.

resumen está disponible en el texto completo

https://doi.org/10.35366/107622

Encefalitis autoinmune por anticuerpos contra el receptor N-metil-D-aspartato (NMDA): serie de casos en niños
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Martínez, Jessica Mariana Suárez

; Zurita, Clara Soto

; Vera, Luis Alberto Aparicio

; Florentín, Cynthia

; Barrios, José Medina

; Vázquez, Jorge

; Morel, Zoilo

Revista Paraguaya de Reumatología

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Jun 2022, Volume 8 Nº 1 Páginas 21 - 26

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen: Se describe una serie de casos de pacientes pediátricos, con encefalitis autoinmune (EA) por anticuerpos contra el receptor N-metil-D-aspartato (NMDA), atendidos en hospitales de tercer nivel en México y Paraguay, y su evolución con inmunoterapia. Los síntomas predominantes fueron fiebre, trastornos del sueño, alucinaciones, discinesias, movimientos coreo-atetósicos, espasticidad, convulsiones y disautonomías. Los pacientes fueron trata- dos con inmunoglobulina humana y metilprednisolona como primera línea, y en algunos casos se requirió el uso de plasmaféresis y anti-CD20. El inicio oportuno de tratamiento se relacionó con una menor estancia hospitalaria y menor desarrollo de complicaciones. Se debe enfatizar el diagnóstico oportuno, implementando su identificación a partir del cuadro clínico, sustentando el diagnóstico con pruebas serológicas adecuadas y hallazgos en LCR, y de este modo favorecer el inicio de tratamiento temprano para reducir complicaciones y días de internación.

Abstract: We describe a case series of pediatric patients with autoimmune encephalitis (AE) due to antibodies against the N-methyl-D-aspartate (NMDA) receptor, treated in tertiary hospitals in Mexico and Paraguay, and their evolution with immunotherapy. The predominant symptoms were fever, sleep disorders, hallucinations, dyskinesias, choreoathetotic movements, spasticity, seizures, and dysautonomia. Patients were treated with IVIG and IV methylprednisolone as first line therapy. In some cases, use of plasmapheresis and anti-CD20 monoclonal antibodies was required. Timely treatment initiation was related to a shorter hospital stay and less development of complications. Timely diagnosis should be emphasized, implementing its identification based on the clinical picture and supporting the diagnosis with adequate serological tests and CSF findings, thus favoring the start of early treatment to reduce complications and days of hospitalization.

https://doi.org/10.18004/rpr/2022.08.01.21

Comparación de los resultados funcionales post operatorios en enucleación prostática con láser holmio, fotovaporización prostática con láser verde y resección transuretral de próstata en el tratamiento de la hiperplasia prostática obstructiva
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Cruz-Ordoñez, Sandra Xochiquetzal

; Chein-Vázquez, María Fernanda

; Victorio-Vargas, Omar Dimas

; Cervantes-Palma, César

; Lemus-Hernández, Luis Alberto

; Toledo-Díaz, Mario Alberto

; Torres-Gómez, Jesús Javier

; Bravo-Castro, Edgar Iván

; Díaz-Gómez, Cristóbal

; Martínez-Alonso, Iván Azael

; Campos-Salcedo, José Gadú

Revista mexicana de urología

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Jun 2022, Volume 82 Nº 3 elocation e07

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Objective: To compare the functional results in patients undergoing transurethral resection of the prostate (TURP), photovaporization of the prostate with GreenLight ® laser (FTV) and prostate enucleation with Holmium laser (HOLEP), for the treatment of benign prostatic obstruction at the Central Military Hospital. Material and methods: The international index of prostate symptomatology questionnaire (IPSS), Uroflowmetry (Qmax), pre and post void ultrasonography (PVR) were applied to patients undergoing TURP, VTF and HOLEP pre and postoperatory from January 2018 to March 2019. Shapiro-Wilks tests were analyzed for quantitative variables; parametric behavioral data were analyzed with ANOVA tests, and non-parametric data were analyzed with Mann-Whitney and Kruskal-Wallis U tests. GraphPad PRISM v7.0 statistical package was used. Results: 46 patients underwent to TURP, 62 to HOLEP and 17 to VFT were evaluated, removing those who did not achieve complete postoperative follow-up; describing the demographic characteristics, the most frequent comorbidities and the parameters evaluated preoperatively. At follow-up, HOLEP was slightly better than FTV or TURP; without finding statistical significance between the groups, observing an important improvement in the reference values of IPSS, Qmax and PVR after surgery in all populations. Conclusions: No superiority of any technique was proven in short-term postoperative functional results, so we propose to perform long-term studies, considering adding trans and postoperative parameters in order to demonstrate superiority of these techniques.

Resumen Objetivo: Comparar los resultados funcionales en pacientes operados de resección transuretral de próstata (RTUP), fotovaporización prostática con láser GreenLight ® (FTV) y enucleación prostática con láser Holmio (HOLEP), en el tratamiento de la obstrucción prostática benigna en el Hospital Central Militar. Material y métodos: Se aplicó cuestionario de índice internacional de sintomatología prostática (IPSS), Uroflujometría (Qmax), ultrasonografía vesical pre y postmiccional (PVR) a los pacientes llevados a RTUP, FTV y HOLEP de manera pre y post operatoria de enero del 2018 a marzo del 2019. Se analizaron las pruebas descriptivas y de normalidad de Shapiro-Wilks para las variables cuantitativas; los datos de comportamiento paramétrico se analizaron con pruebas de ANOVA, y los no paramétricos se analizaron con pruebas de U de Mann-Whitney y Kruskal-Wallis. Se utilizó paquete estadístico GraphPad PRISM v7.0. Resultados: Se evaluaron 46 pacientes de RTUP, 62 de HOLEP y 17 de FTV, eliminando aquellos que no lograron seguimiento postoperatorio completo; describiendo las características demográficas, las comorbilidades más frecuentes y los parámetros evaluados de manera preoperatoria. En el seguimiento, HOLEP fue ligeramente mejor que FTV o RTUP; sin encontrar significancia estadística entre los grupos, observando mejoría marcada de los valores de referencia de IPSS, Qmax y PVR pre y post operatorios en todas las poblaciones. Conclusiones: No se comprobó superioridad de alguna de las técnicas en cuanto a resultados funcionales postoperatorios a corto plazo, por lo que se propone realizar estudios a largo plazo, considerando agregar parámetros trans y postoperatorios a fin de demostrar superioridad de estas técnicas.

https://doi.org/10.48193/revistamexicanadeurologa.v82i3.743

10.

Volviéndonos mejores: necesidad de acción inmediata ante el reto de la obesidad. Una postura de profesionales de la salud
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Barquera, Simón

; Véjar-Rentería, Lesly Samara

; Aguilar-Salinas, Carlos

; Garibay-Nieto, Nayely

; García-García, Eduardo

; Bonvecchio, Anabelle

; Perichart, Otilia

; Torres-Tamayo, Margarita

; Esquivias-Zavala, Héctor

; Villalpando-Carrión, Salvador

; García-Méndez, Rosalba Carolina

; Apolinar-Jiménez, Evelia

; Kaufer-Horwitz, Martha

; Martínez-Montañez, Olga Georgina

; Fajardo Niquete, Ileana

; Aguirre-Crespo, Alejandra

; Gómez-Álvarez, Enrique

; Hernández-Jiménez, Sergio C.

; Denova-Gutiérrez, Edgar

; Batis, Carolina

; Elías-López, Daniel

; Palos-Lucio, Ana Gabriela

; Vásquez-Garibay, Edgar M.

; Romero-Velarde, Enrique

; Ortiz-Rodríguez, María Araceli

; Almendra-Pegueros, Rafael

; Contreras, Alejandra

; Nieto, Claudia

; Hernández-Cordero, Sonia

; Munguía, Ana

; Rojas-Russell, Mario

; Sánchez-Escobedo, Samantha

; Delgado-Amézquita, Elvia

; Aranda-González, Irma

; Cruz-Casarrubias, Carlos

; Campos-Nonato, Ismael

; García-Espino, Fátima

; Martínez-Vázquez, Sophia

; Arellano-Gómez, Laura P.

; Caballero-Cantú, Idalia

; Hunot-Alexander, Claudia

; Valero-Morales, Isabel

; González-González, Lorena

; Ríos-Cortázar, Víctor

; Medina-García, Catalina

; Argumedo, Gabriela

; Calleja-Enríquez, Carmen Rosa

; Robles-Macías, Edna

; Nava-González, Edna J.

; Lara-Riegos, Julio

; Sánchez-Plascencia, Ana K.

; Hernández-Fernández, Mauricio

; Rodríguez-Núñez, Jose Luis

; Rangel-Quillo, Sarai

; Cancino-Marentes, Martha Edith

; Hernández-Viana, Mónica J.

; Saldivar-Frausto, Mariana

; Álvarez-Ramírez, Miriam

; Sandoval-Salazar, Cuauhtémoc

; Silva-Tinoco, Rubén Oswaldo

; Moreno-Villanueva, Mildred

; Villarreal-Arce, María Elena

; Barriguete, J. Armando

; White, Mariel

; Jauregui, Alejandra

; Tolentino-Mayo, Lizbeth

; López-Ridaura, Ruy

; Rivera-Dommarco, Juan

Salud Pública de México

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Abr 2022, Volume 64 Nº 2 Páginas 225 - 229

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract: In recent decades, the growing obesity epidemic in Mexico has become one of the most important public health challenges faced by the country. With support from the World Obesity Federation, we formed a working group in 2021 to identify and summarize priority actions that Mexico can take to face this epidemic. More than 1 000 health professionals joined the development and discussion process. Recommendations from previously published, high-level documents and guidelines were taken into account. In commemoration of World Obesity Day 2022, this statement is presented as input for health care professionals to develop actions to address obesity. The statement includes 10 recommendations that include population-level and individual-level actions. It emphasizes the importance of social participation, comprehensive interventions with a person- centered perspective, planetary sustainability, on improving education and communication campaigns, as well as fostering a built environment that promotes active living, and shielding prevention and control efforts from conflicts of interest. The statement calls for obesity to be treated seriously, based on scientific evidence, in a timely and comprehensive manner, employing a life-course and ethical approach that does not perpetuate weight stigma in society.

resumen está disponible en el texto completo

https://doi.org/10.21149/13679

11.

Guía de práctica clínica mexicana para el diagnóstico y tratamiento de las dislipidemias y enfermedad cardiovascular aterosclerótica
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Pavía-López, Abel A.

; Alcocer-Gamba, Marco A.

; Ruiz-Gastelum, Edith D.

; Mayorga-Butrón, José L.

; Mehta, Roopa

; Díaz-Aragón, Filiberto A.

; Aldrete-Velasco, Jorge A.

; López-Juárez, Nitzia

; Cruz-Bautista, Ivette

; Chávez-Mendoza, Adolfo

; Secchi-Nicolás, Nikos C.

; Guerrero-Martínez, Francisco J.

; Cossio-Aranda, Jorge E.

; Mendoza-Zubieta, Victoria

; Fanghänel-Salmon, Guillermo

; Valdivia-Proa, Martha

; Olmos-Domínguez, Luis

; Aguilar-Salinas, Carlos A.

; Dávila-Maldonado, Luis

; Vázquez-Rangel, Armando

; Pavia-Aubry, Vanina

; Nava-Hernández, María de los A.

; Hinojosa-Becerril, Carlos A.

; Anda-Garay, Juan C.

; Ríos-Ibarra, Manuel O. de los

; Berni-Betancourt, Ana C.

; López-Cuellar, Julio

; Araiza-Garaygordobil, Diego

; Rivera-Reyes, Romina

; Borrayo-Sánchez, Gabriela

; Tapia-Hernández, Mónica

; Cano-Nigenda, Claudia V.

; Guerra-López, Arturo

; Elías-López, Josué

; Figueroa-Morales, Marco A.

; Montaño-Velázquez, Bertha B.

; Velasco-Hidalgo, Liliana

; Rodríguez-Lozano, Ana L.

; Pimentel-Hernández, Claudia

; Baquero-Hoyos, María M.

; Romero-Moreno, Felipe

; Rodríguez-Vega, Mario

Archivos de cardiología de México

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2022, Volume 92 Supl. 1 Páginas 1 - 62

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

resumen está disponible en el texto completo

Abstract Background: Cardiovascular diseases are the leading cause of mortality worldwide and Mexico is no exception. The epidemiological data obtained in 1990 showed that cardiovascular diseases represented 19.8% of all causes of death in our country. This figure increased significantly to 25.5% for 2015. Some national surveys suggest that more than 60% of the adult population has at least one risk factor for cardiovascular disease (obesity or overweight, hypertension, smoking, diabetes, dyslipidemias). On the other hand, data from the Pan American Health Organization have linked the process of atherosclerosis as the first cause of premature death, significantly reducing life expectancy, which has enormous social repercussions. Objective: This document constitutes the Clinical Practice Guide (CPG) prepared at the initiative of the Mexican Society of Cardiology in collaboration with the Mexican Society of Nutrition and Endocrinology, AC, National Association of Cardiologists of Mexico, AC, Mexican Association for the Prevention of Atherosclerosis and its Complications, AC, National Normative Committee of General Medicine, AC, National College of Geriatric Medicine, AC, College of Internal Medicine of Mexico, AC, Mexican Society of Angiology and Vascular and Endovenous Surgery, AC, Mexican Institute of Research Nephrological, AC and the Mexican Academy of Neurology, A.C.; with the methodological support of the Ibero-American Agency for the Development and Evaluation of Health Technologies, in order to establish recommendations based on the best available evidence and agreed upon by an interdisciplinary group of experts. The objective of this document is to provide evidence-based recommendations to help decision makers in the diagnosis and treatment of dyslipidemias in our country. Material and methods: This document complies with international quality standards, such as those described by the Institute of Medicine of the USA, the Institute of Clinical Excellence of Great Britain, the Scottish Intercollegiate Guideline Network and the Guidelines International Network. A multidisciplinary group of clinical experts and methodologists with experience in systematic reviews of the literature and the development of clinical practice guidelines was formed. A scope document was agreed upon, relevant clinical questions were established, the best available evidence critically evaluated in systematic literature reviews was exhaustively identified, and clinical recommendations were developed. The modified Delphi Panel methodology was used to achieve an adequate level of consensus in each of the recommendations contained in this CPG. Results: 23 clinical questions were agreed upon which gave rise to their respective clinical recommendations. Conclusions: We consider that this document contributes to better clinical decision-making and becomes a point of reference for clinicians and patients in the management of dyslipidemias and this contributes to reducing the morbidity and mortality derived from atherosclerotic cardiovascular events in our country.

https://doi.org/10.24875/acm.m22000081 1458 downloads

12.

Mecanismos de acción de los brasinoesteroides y sus análogos en las respuestas de plantas sometidas a estrés abióticos
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Reyes Guerrero, Yanelis

; Núñez Vázquez, Miriam

; Mazorra Morales, Luis Miguel

; Martínez González, Lisbel

; Ravelo Agüero, Elisa

; Dell´Amico Rodríguez, José

; Menéndez Rodríguez, Jorge L.

; Pérez Domínguez, Geydi

Anales de la Academia de Ciencias de Cuba

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Ago 2021, Volume 11 Nº 2 elocation e873

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: Brassinosteroids and their analogues are compounds that have been successfully used in the tolerance induction to abiotic stresses in plants, at international level. The main objective of this research was to determine the effect that the exogenous application of brassinosteroids and their analogues exerted on the tomato seedling tolerance to high temperature stress and the role of brassinosteroid homeostasis and oxidative stress in this tolerance. The effects that brassinosteroids and their analogues exerted on rice plant growth under saline stress and the main physiological and biochemical mechanisms associated with this response, were also determined. Methods: An experiment was carried out in which different genotypes were used. They were characterized by genetic changes that produce different endogenous levels of castasterone. In order to combine the theoretical interest with the practical one, experiments with genotype Amalia were conducted. This crop is widespread in Cuba. So as to determine the influence of treating the seeds with BR and their analogues during the growth of rice seedlings in a saline environment, several experiments were run in semi-controlled conditions. Results: The performed experiments demonstrated that the thermotolerance of tomato seedlings depends on kinase domain activity of the brassinosteroid tBRI1 receptor, as well as the participation of oxidative stress in the BR-induced thermotolerance. Furthermore, MH-5 analogue was more effective in protecting Amalia tomato seedlings from thermal shock than BB-6. Regarding the rice plant protection from salt stress, for the first time, in an integral manner, the physiological and biochemical responses associated with 24-epibrassinolide (EBL) and Biobras-16 induced protection are reported; it allowed for proposing an EBL action model in rice plants under these conditions. It was demonstrated that both compounds protected the plants; however, the physiological and biochemical responses associated with this protection are different.

RESUMEN Introducción: Los brasinoesteroides (BR) y sus análogos son compuestos que han sido utilizados satisfactoriamente, a nivel internacional, en la inducción de tolerancia a estreses abióticos en las plantas. El objetivo fundamental de esta investigación fue determinar el efecto que la aplicación exógena de los brasinoesteroides y sus análogos ejercían en la tolerancia de plántulas de tomate al estrés por temperaturas altas y el papel de la homeostasis de brasinoesteroides y del estrés oxidativo en dicha tolerancia. Además, determinar los efectos que los brasinoesteroides y sus análogos ejercen en el crecimiento de plantas de arroz sometidas a estrés salino, así como los principales mecanismos fisiológicos y bioquímicos asociados a esta respuesta. Métodos: Se ejecutó un experimento donde se utilizaron diferentes genotipos caracterizados por cambios genéticos que originan niveles endógenos diferentes de la castasterona. Para combinar el interés teórico con el práctico se ejecutaron experimentos con el genotipo Amalia, cultivo extendido en Cuba Para determinar la influencia que ejercía el tratamiento a las semillas con BR y sus análogos en el crecimiento de plántulas de arroz en medio salino, se ejecutaron varios experimentos en condiciones semicontroladas. Resultados: Los experimentos ejecutados demostraron que, la termotolerancia de plántulas de tomate depende de la actividad del dominio quinasa del receptor tBRI1 de los BR, así como la participación del estrés oxidativo en la termotolerancia inducida por estos compuestos. Se informó, también, que el análogo MH-5 fue más efectivo que el BB-6, en proteger a las plántulas de tomate cultivar Amalia del choque térmico. En cuanto a la protección de las plantas de arroz ante el estrés salino, se informan, por primera vez, de manera integral, las respuestas fisiológicas y bioquímicas asociadas a la protección inducida por la 24-epibrasinólida (EBL) y el Biobras-16; lo que permitió proponer un modelo de acción de la EBL en plantas de arroz sometidas a estas condiciones. Se demostró, que, aunque ambos compuestos protegieron a las plantas, las respuestas fisiológicas y bioquímicas asociadas a dicha protección son diferentes.

13.

Impact of the use of sexual material and online sexual activity during preventive social isolation due to COVID-19
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Hernández-Torres, José Luis

; Rodríguez-Vázquez, Nancy

; Martínez-Cervantes, Roxana

; Cárdenas-Cortés, Adriana Mayela

; Gómez-Melasio, Dafne Astrid

; Trujillo-Hernández, Pedro Enrique

Salud mental

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Ago 2021, Volume 44 Nº 4 Páginas 185 - 192

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Introduction Preventive social isolation due to coronavirus disease (COVID-19) has represented one of the greatest health challenges of the last decades worldwide. As a result of social isolation, the consumption of information in digital media, such as the use of online sexual material, has increased, leading to risky sexual behavior in young people. Objective To quantify the impact on the use and type of online sexual material and to determine the predictors of online sexual activity in people in preventive social isolation due to COVID-19. Method Multivariate cross-sectional study; 385 participants were studied and contacted through an online survey. Results Internet pages and social networks are the main platforms for the use of online sexual material, and its consumption was more frequent in those who had more days of preventive social isolation. Predictors of sexual activity were cybersex (β = .38), excitation (β = .36), masturbation (β = .34), and adventure (β = .33), which were found to be statistically significant ( p ˂ .001). Discussion and conclusion Privacy plays an important role in the use of online sexual material and activities, and greater consumption can be found in intimacy. It is important to be alert to the effects of the pandemic on sexual risk behavior and further research is needed.

Resumen Introducción El aislamiento social preventivo por la enfermedad por coronavirus (COVID-19) ha representado uno de los mayores retos de salud en las últimas décadas en todo el mundo. Como resultado del aislamiento social se ha elevado el consumo de información en medios digitales, como el uso de material sexual en línea, lo que ha propiciado un comportamiento sexual de riesgo en los jóvenes. Objetivo Cuantificar el impacto en el uso y el tipo de material sexual en línea y determinar los predictores de actividades sexuales en línea en personas en aislamiento social preventivo debido al COVID-19. Método Estudio multivariado de corte transversal; se estudiaron 385 participantes contactados por medio de una encuesta en línea. Resultados Las páginas de internet y las redes sociales son las principales plataformas para el uso de material sexual en línea y este consumo se dio con más frecuencia en quienes tenían más días de aislamiento social preventivo. Los predictores de las actividades sexuales fueron el cibersexo (β = .38), la excitación (β = .36), la masturbación (β = .34) y aventura (β = .33), encontrándose estadísticamente significativas ( p ˂ .001). Discusión y conclusión La privacidad cumple un papel importante en el uso de material y actividades sexuales en línea, en la intimidad se puede encontrar un mayor consumo. Es importante estar alerta a los efectos que la pandemia causa en relación a las conductas sexuales de riesgo y seguir investigando sus efectos es necesario.

https://doi.org/10.17711/sm.0185-3325.2021.024 34 downloads

14.

Calidad de la proteína en líneas e híbridos experimentales de QPM. Altiplano Central, México
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Arellano-Vázquez, José Luis

; Gutiérrez-Hernández, Germán Fernando

; Flores-Gómez, Estela

; López-Martínez, Daniel Eduardo

Agronomía Mesoamericana

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Abr 2021, Volume 32 Nº 1 Páginas 107 - 119

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Introducción. Actualmente el maíz es el grano más cultivado en el mundo y es factible mejorar la nutrición de sus consumidores mediante el desarrollo del maíz con proteína de calidad (QPM, en inglés), cuya base es la expresión del gen opaco2, la cual incrementa los contenidos de lisina y triptófano del grano. Objetivo. Analizar químicamente la proteína del grano de líneas e híbridos simples experimentales de QPM y conocer las relaciones entre el genotipo y las variables evaluadas de la calidad proteica. Materiales y métodos. Los experimentos se efectuaron durante el 2017 en la Unidad Profesional Interdisciplinaria de Biotecnología del Instituto Politécnico Nacional (Ciudad de México). Se utilizaron granos enteros de líneas parentales (P1 a P6) y de los híbridos simples directos. Se estimaron lisina, triptófano, y cantidad y calidad de proteína. Se utilizó un diseño completamente al azar con tres repeticiones. Se hicieron análisis de varianza, comparación de medias y análisis de componentes principales. Resultados. Se identificaron como QPM significativos (p ≤ 0,05) a las líneas P2, P3 y P6, y a los híbridos P2 x P4 y P2 x P6. El índice de calidad de proteína se correlacionó con el triptófano (r = 0,9*) y la lisina (r = 0,7*), pero no con la proteína total. Conclusiones. El factor fundamental para desarrollar los QPM fueron los aminoácidos esenciales y la limitante para incrementar su valor nutricional fue la calidad de proteína.

Abstract Introduction. Currently, maize is the most cultivated grain in the world and it is feasible to improve the nutrition of its consumers through the development of quality protein maize (QPM), whose basis is the expression of the opaque2 gene, which increases the contents of lysine and tryptophan in the grain. Objective. To analyze chemically the protein of the grain of lines and experimental simple hybrids of QPM and to know the relationships between the genotype and the evaluated variables of protein quality. Materials and methods. The experiments were carried out during 2017 in the Interdisciplinary Professional Unit of Biotechnology of the Instituto Politecnico Nacional (Mexico City). Whole grains of parental lines (P1 to P6) and direct simple hybrids were used. Lysine, tryptophan, and protein quantity and quality were estimated. A completely randomized design with three replications was used. Analysis of variance, comparison of means, and principal component analysis were performed. Results. Lines P2, P3, and P6, and hybrids P2 x P4 and P2 x P6 were identified as significant (p ≤ 0.05) QPM. The protein quality index was correlated with tryptophan (r = 0.9 *) and with lysine (r = 0.7 *) but not with total protein. Conclusions. The fundamental factor for developing the QPM were the essential amino acids and the limiting factor for increasing their nutritional value was the quality of the protein.

https://doi.org/10.15517/am.v32i1.40439

15.

Point-of-care ultrasound by the pediatrician in the diagnosis and follow-up of community-acquired pneumonia,
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Toro, Manuel Sobrino

; Martínez, José Luis Vázquez

; Falcão, Ricardo Viana

; Prata-Barbosa, Arnaldo

; Cunha, Antonio José Ledo Alves da

Jornal de Pediatria

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Fev 2021, Volume 97 Nº 1 Páginas 13 - 21

Resumo: En | Texto: En | PDF: En

Abstract Objectives: To review, analyze, and present the available evidence on the usefulness of point-of-care pulmonary ultrasound in the diagnosis and monitoring of community-acquired pneumonia (CAP), aiming to facilitate its potential inclusion into pediatric clinical reference guidelines. Source of data: A non-systematic research was carried out in the MEDLINE (PubMed), LILACS, and SciELO databases, from January 1985 to September 2019. The articles that were considered the most relevant were selected. Synthesis of data: CAP is a relevant cause of morbidity and mortality in pediatrics and its clinical management remains a major challenge. The systematic use of chest X-ray for its diagnosis is controversial because it exposes the child to ionizing radiation and there are interobserver differences in its interpretation. Recently, the use of point-of-care pulmonary ultrasound by the pediatrician has been presented as an alternative for the diagnosis and monitoring of CAP. A great deal of evidence has disclosed its high sensitivity and diagnostic specificity, with the advantages of no ionizing radiation, relatively low cost, immediate results, portability, and the possibility of repetition according to the requirements of disease evolution. Moreover, its use can help rule out possible bacterial etiology and thus prevent inappropriate antibiotic treatments that favor bacterial resistance. Conclusions: Point-of-care ultrasonography represents an opportunity to improve the diagnosis and monitoring of CAP. However, as an operator-dependent technique, training is required for adequate image acquisition, correct interpretation, and integration with clinical data for correct decision-making.

https://doi.org/10.1016/j.jped.2020.07.003 402 downloads

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la	código do idioma da publicação (ex. pt - Português, es - Espanhol)
type	tipo do documento
pid	identificador da publicação
publication_year	ano de publicação do artigo
sponsor	financiador
aff_country	código do país de afiliação do autor
aff_institution	instituição de afiliação do autor
volume	volume do artigo
issue	número do artigo
elocation	elocation
doi	número DOI
issn	ISSN da revista
in	código da coleção SciELO (ex. scl - Brasil, col - Colômbia)
use_license	código da licença de uso do artigo

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