Abstract: Objective: To analyze the process of design and implementation of AUGE. Materials and methods: Literature review of pre-reform background, architecture design and implementation process of reform AUGE and complementary interviews to eight informants involved in its development. Results: The assessment of health equity was a key element in pre-reform, there are four fundamental dimensions in the design, and the implementation has nine phases. Conclusion: The results show AUGE strengthening public health by investing in equipment for cost-effective treatments, and also through clinical guidelines that standardize and guide the management of health professionals with patients.

Resumen: Objetivo: Analizar el proceso de diseño e implementación del Acceso Universal con Garantías Explícitas (AUGE). Material y métodos: Revisión de bibliografía sobre antecedentes prerreforma, arquitectura de diseño y proceso de implementación de la reforma AUGE y, complementariamente, entrevistas a ocho informantes involucrados en su desarrollo. Resultados: La valoración de la equidad en la salud fue un elemento clave prerreforma; existen cuatro dimensiones fundamentales en el diseño y nueve fases en la implementación. Conclusión: Los resultados del AUGE muestran un fortalecimiento en la salud pública por la inversión en equipamiento para tratamientos costo-efectivos; también por las guías clínicas que estandarizan y orientan la gestión de los profesionales de la salud con los pacientes.

Abstract: Objective: To analyze the process of design and implementation of AUGE. Materials and methods: Literature review of pre-reform background, architecture design and implementation process of reform AUGE and complementary interviews to eight informants involved in its development. Results: The assessment of health equity was a key element in pre-reform, there are four fundamental dimensions in the design, and the implementation has nine phases. Conclusion: The results show AUGE strengthening public health by investing in equipment for cost-effective treatments, and also through clinical guidelines that standardize and guide the management of health professionals with patients.

Resumen: Objetivo: Analizar el proceso de diseño e implementación del Acceso Universal con Garantías Explícitas (AUGE). Material y métodos: Revisión de bibliografía sobre antecedentes prerreforma, arquitectura de diseño y proceso de implementación de la reforma AUGE y, complementariamente, entrevistas a ocho informantes involucrados en su desarrollo. Resultados: La valoración de la equidad en la salud fue un elemento clave prerreforma; existen cuatro dimensiones fundamentales en el diseño y nueve fases en la implementación. Conclusión: Los resultados del AUGE muestran un fortalecimiento en la salud pública por la inversión en equipamiento para tratamientos costo-efectivos; también por las guías clínicas que estandarizan y orientan la gestión de los profesionales de la salud con los pacientes.

BACKGROUND: Extracellular metolloproteases have been implied in different process such as cell death, differentiation and migration. Membrane-bound metalloproteases of the ADAM family shed the extracellular domain of many cytokines and receptor controlling auto and para/juxtacrine cell signaling in different tissues. ADAM17 and ADAM10 are two members of this family surface metalloproteases involved in germ cell apoptosis during the first wave of spermatogenesis in the rat, but they have other signaling functions in somatic tissues. RESULTS: In an attempt to further study these two enzymes, we describe the presence and localization in adult male rats. Results showed that both enzymes are detected in germ and Sertoli cells during all the stages of spermatogenesis. Interestingly their protein levels and cell surface localization in adult rats were stage-specific, suggesting activation of these enzymes at particular events of rat spermatogenesis. CONCLUSIONS: Therefore, these results show that ADAM10 and ADAM17 protein levels and subcellular (cell surface) localization are regulated during rat spermatogenesis.