Abstract Neurocutaneous syndromes comprise a heterogeneous group of congenital or hereditary conditions that are known to be associated with the risk of different disorders and complications. Two of the most common neurocutaneous syndromes are Neurofibromatosis type 1 (NF1) and Tuberous Sclerosis Complex (TSC). Although there appears to be a general consensus on the importance of a multidisciplinary approach in managing these cases, there is still very little emphasis in discussions addressed in the literature on the role of dentistry in accordance with the perspective of comprehensive care. Evidence-based propositions, together with a broad discussion of new insights in this regard, should have the ability to strongly impact related future perspectives, aiming for greater advances and better outcomes for these patients. In this review article, the authors discuss updated general aspects of NF1 and TSC, and the potential additional roles of dentistry, in addition to addressing suggestions for actions in dentistry at related levels of care, as well as priorities for future research. complications NF (NF1 TSC. TSC . (TSC) cases care Evidencebased Evidence based propositions regard perspectives patients article research (NF (TSC

Abstract Class III malocclusion is a relevant public health problem. The management of severe skeletal class III malocclusion in non-growing patients requires properly planned and well-executed orthognathic surgery by a team of at least an orthodontist and a maxillofacial surgeon. For these cases, there are two approaches to the surgery. One of them is the conventional three-stage method, which includes preoperative orthodontic treatment, orthognathic surgery, and postoperative orthodontic treatment. The other is the surgery-first orthognathic approach, which is performed without pre-surgical orthodontic treatment and should present some advantages compared to the conventional technique. However, at present, evidence on the management of class III malocclusion still needs to be expanded. In this paper, we present the management of a case of severe skeletal class III malocclusion by surgery-first orthodontic approach, based on the experience of the Tamil Nadu Government Dental College and Hospital, Chennai, India.

Resumen La maloclusión clase III es un problema de salud pública importante. El tratamiento de la maloclusión clase III esquelética grave en pacientes que no están en crecimiento, requiere una cirugía ortognática planificada de forma apropiada y bien ejecutada, por un equipo de al menos un ortodoncista y un cirujano maxilofacial. Para estos casos, existen dos enfoques para la cirugía: el método convencional de tres etapas, que incluye tratamiento de ortodoncia preoperatorio, cirugía ortognática y tratamiento de ortodoncia posoperatorio; y el abordaje primario de cirugía ortognática, que se realiza sin tratamiento de ortodoncia prequirúrgico y debe presentar algunas ventajas en comparación con la técnica convencional. Sin embargo, en la actualidad, las pruebas sobre el abordaje de la maloclusión clase III aún deben ampliarse. En este artículo, presentamos el abordaje de un caso de maloclusión clase III esquelética grave mediante el abordaje inicial con cirugía ortognática, basado en la experiencia del Hospital y Colegio Odontológico del Gobierno de Tamil Nadu, Chennai, India.

Resumen As fissuras labiopalatinas são as malformações craniofaciais mais frequentes na (El labio leporino y el paladar hendido son las malformaciones cranofaciales más frecuentes en la) espécie humana. O processo de reabilitação para indivíduos com fissuras labiopalatinas é muitas vezes longo e requer a (muchas veces es extenso y requiere la) realização de vários procedimentos cirúrgicos. Quase sempre, essas cirurgias são (Generalmente, esas cirugías son) realizadas com o uso de profilaxia antibiótica. No entanto, não há consenso sobre esse assunto (Sin embargo, no hay consenso acerca de esta cuestión), bem como sobre as várias implicações (si bien hay muchas consideraciones) existentes. Assim, levando em consideração o alto custo, as peculiaridades e a novidade tecnológica do uso da (De esta manera, considerando el alto costo, las particularidades y la innovación tecnológica del uso de la) proteína morfogenética óssea recombinante humana tipo- 2 (rhBMP-2) nas cirurgias de enxerto (en las cirugías de injerto) alveolar secundário para o tratamento de indivíduos com fissuras labiopalatinas, foi elaborado este trabalho de revisão narrativa. É discutido neste artigo acerca do uso da (Este artículo presenta la discusión acerca del uso de la) profilaxia antibiótica cirúrgica frente às condições do ambiente bucal, o período pós-operatório e prognóstico para esses indivíduos.

Abstract Cleft lip and palate are the most frequent craniofacial malformations in the in human species. The rehabilitation process for individuals with cleft lip and palate is often long and requires several surgical procedures. Almost always, these surgeries are are performed with the use of antibiotic prophylaxis. However, there is no consensus on this issue, as well as on the various implications that exist. Thus, tthis narrative review article was carried out taking into account the high cost, the peculiarities and the technological novelty of the use of type 2 human recombinant bone morphogenetic protein (rhBMP- 2) in secondary alveolar graft surgeries for the treatment of individuals with cleft lip and palate. Therefore the present article discusses the use of surgical antibiotic prophylaxis in the face of the oral environment conditions, the postoperative period and prognosis for these individuals.