Abstract Objective Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and social interaction and by restricted and repetitive patterns of behavior. Some studies have shown that substances derived from Cannabis sativa improve the quality of life of children with ASD without causing serious adverse effects, thus providing an alternative therapeutic option. The objective of this study was to evaluate the efficacy and safety of a cannabis extract rich in cannabidiol (CBD) in children with ASD. Methods In this randomized, double-blind, placebo-controlled clinical trial, 60 children, aged from 5 to 11 years, were selected and divided into two groups: the treatment group, which received the CBD-rich cannabis extract, and the control group, which received the placebo. They both used their respective products for a period of 12 weeks. Statistical analysis was done by two-factor mixed analysis of variance (two-way ANOVA). Results Significant results were found for social interaction (F1,116 = 14.13, p = 0.0002), anxiety (F1,116 = 5.99, p = 0.016), psychomotor agitation (F1,116 = 9.22, p = 0.003), number of meals a day (F1,116 = 4.11, p = 0.04), and concentration (F1,48 = 6.75, p = 0.01), the last of which was only significant in mild ASD cases. Regarding safety, it was found that only three children in the treatment group (9.7%) had adverse effects, namely dizziness, insomnia, colic, and weight gain. Conclusion CBD-rich cannabis extract was found to improve one of the diagnostic criteria for ASD (social interaction), as well as features that often co-exist with ASD, and to have few serious adverse effects. (ASD behavior effects option CBD (CBD randomized doubleblind, doubleblind double blind, blind double-blind placebocontrolled placebo controlled trial 6 1 years groups CBDrich weeks twofactor factor twoway way ANOVA. ANOVA . ANOVA) F1,116 F1116 F F1 116 (F1,11 1413 14 13 14.13 0.0002, 00002 0.0002 , 0 0002 0.0002) 599 99 5.99 0.016, 0016 0.016 016 0.016) 922 9 22 9.22 0.003, 0003 0.003 003 0.003) 411 4 4.11 0.04, 004 0.04 04 0.04) F1,48 F148 48 (F1,4 675 75 6.75 0.01, 001 0.01 01 0.01) cases 9.7% 97 7 (9.7% dizziness insomnia colic gain interaction, interaction) coexist co exist F1,11 F111 (F1,1 141 14.1 0000 0.000 000 59 5.9 92 2 9.2 0.00 00 41 4.1 0.0 F1,4 F14 (F1, 67 6.7 9.7 (9.7 F1,1 F11 14. 5. 9. 4. 0. F1, (F1 6. (9. (F (9 (

Resumen Estudios han demostrado que la depresión y la ansiedad están asociados a cambios en el reconocimiento de la expresión facial. En la presente investigación, una muestra no clínica ha sido evaluada con respecto a la ansiedad rasgo y estado y los síntomas de depresión. En la tarea experimental, los participantes evaluaran expresiones faciales de alegría, ira, tristeza y miedo, presentadas en cuatro intensidades (25, 50, 75 y 100%), y el rostro neutro. Los resultados mostraron que la ansiedad rasgo se asoció con un mejor reconocimiento de la ira, miedo y alegría. Para la depresión, sólo se encontraron diferencias entre los grupos para la atribución emocional a rostros neutros, en el que los participantes que puntuaran alto en depresión eran más propensos a atribuir miedo a rostros neutros. Los resultados indican una mejora del reconocimiento de la alegría, ira y miedo en la ansiedad rasgo, mientras que los síntomas de depresión y ansiedad estado están asociados a cambios en la evaluación de rostros neutros en individuos no clínicos.

Abstract Previous studies have shown that depression and anxiety are associated to changes in the recognition of facial expression. In the present research, a non-clinical sample was evaluated with respect to trait and state anxiety and depression symptoms. In the experimental task, participants evaluated facial expressions of happiness, anger, sadness, and fear, presented at four intensities (25, 50, 75, and 100%), as well as the neutral face. Results showed that the trait anxiety was associated with a better recognition of anger, fear, and happiness. For depression, we only found differences between groups for emotional attribution to neutral faces, in which participants scoring high in depression were more likely to attribute fear to neutral faces. Findings indicate an improvement of the recognition of happiness, anger, and fear in trait anxiety, whereas symptoms of depression and state anxiety were associated to changes in the evaluation of neutral faces in non-clinical individuals.

In the aging process, changes in perception and cognition may lead to losses in the recognition of facial emotions. In this study, we carried out, according to PRISMA guidelines, a systematic review of recent studies that evaluated the perception and facial emotion recognition in the elderly without pathologies. Searches occurred in the electronic databases: MEDLINE, PsycoINFO and Web of Science, being selected 22 articles published between 2009 and 2016. In general, we found that elderly show a decline in emotion recognition, mainly for negative emotions. These results can be explained by the structural theory as well as by theory of the socioemotional selectivity. The results have important implications inasmuch as they indicate the relevance of cognitive assessment and use of more ecological stimuli in emotion recognition tasks in elderly.

No processo de envelhecimento, alterações na percepção e na cognição podem gerar prejuízos no reconhecimento de emoções faciais. No presente trabalho, foi realizada uma revisão sistemática, de acordo com as diretrizes do PRISMA, de estudos recentes que avaliaram a percepção e o reconhecimento facial de emoções em idosos sem patologias. As bases eletrónicas de dados pesquisadas foram: MEDLINE, PsycoINFO e Web of Science, sendo selecionados 22 artigos publicados entre 2009 e 2016. De um modo geral, verificou-se que os idosos apresentaram um declínio no reconhecimento de emoções, principalmente para as emoções negativas. Tais resultados podem ser explicados tanto pela teoria estrutural, quanto pela teoria da seletividade socioemocional. Os resultados têm importantes implicações na medida em que sinalizam a relevância da avaliação cognitiva e do uso de estímulos mais ecológicos nas tarefas de reconhecimento emocional em idosos.

The ability to recognize emotions in faces is essential to human interaction and occurs since childhood. Hypothesis: research using the morphing technique assume that children require greater or lesser intensity of emotional expression to perceive it. Objective: to examine the emotional recognition of faces in childhood, using a task with emotional intensity variation. Method: it was applied a Test of Facial Emotion Recognition for Children to 28 children between 7 and 11 years, of both sexes, which presented 168 faces manipulated by the morphing technique, of the six basic emotions. Results: age as a trend growth of the likelihood of success at the task; more right answers for happiness and worst performances for fear; and the emotional intensity increasing at 42% the chance of success by every unit of intensity. Conclusion: these findings are relevant because they show the recognition of emotions at different levels as a more sensitive method.

Resumo Em geral, a experiência de proporcionar assistência e lidar com as complicações da pessoa com doença de Alzheimer coloca os cuidadores em uma situação de alto risco, vulnerabilidade e estresse, causando sérios problemas físicos e emocionais. Entretanto, existem cuidadores com uma mentalidade resiliente que os leva a experimentar e expressar sentimentos positivos e uma menor sobrecarga associada ao cuidado. Esta experiência positiva acontece porque percebem o processo de cuidar como menos prejudicial. Enfrentam a situação de cuidado com uma atitude mais positiva e são capazes de resistir e manter um funcionamento adaptativo. O objetivo desta revisão narrativa da literatura foi indicar a necessidade de se desenvolver programas de intervenção para o cuidador, com base em modelos salutogênicos, de resiliência, resistência e crescimento pessoal, para promover os recursos positivos da pessoa, da família e da comunidade.

Abstract In general, the experience of providing assistance to and dealing with the complications experienced by a person with Alzheimer's disease puts caregivers in a situation of high risk, vulnerability, and stress, causing serious physical and emotional problems. However, some caregivers adopt a resilient mindset, which helps them to experience and express positive feelings as well as lower their burden in relation to the care. This positive experience occurs because caregivers perceive the process of caring as less adverse. They face the situation of care with a more positive mindset and are able to resist and maintain adaptive functioning. The objective of the present narrative literature review was to emphasize the need to develop intervention programs for caregivers based on salutogenic models of resilience, resistance, and personal growth to promote positive individual, family, and community resources.

Resumen En general, la experiencia de proporcionar asistencia y lidiar con las complicaciones del enfermo de Alzheimer sitúa a los cuidadores en una situación de alto riesgo, vulnerabilidad y estrés, ocasionando importantes problemas físicos y emocionales en muchos familiares. En cambio, existen cuidadores que disponen de una mentalidad resiliente que les protege y lleva a experimentar sentimientos positivos y experimentar menor sobrecarga. Esta experiencia positiva sucede porque interpretan el proceso de cuidado como menos negativo, afrontan la situación con una actitud positiva y son capaces de resistir y mantener un funcionamiento adaptativo. El objetivo de esta revisión narrativa da literatura fue señalar la necesidad de desarrollar programas de intervenciones centradas en el cuidador que promuevan los modelos salutogénicos, de resistencia, resistencia y crecimiento personal, para potenciar los recursos positivos del cuidador, de la familia y de la comunidad.

RESUMO: O objetivo desta revisão de literatura foi verificar as evidências científicas e restrições dos diferentes tipos de tratamentos para voz na Doença de Parkinson. O levantamento dos artigos foi realizado nas bases de dados PubMed/MEDLINE, SciELO e Lilacs. Utilizou-se como estratégia de busca as combinações com os seguintes descritores: "Parkinson disease and vocal therapy"; "Parkinson disease and speech acoustic"; "Parkinson disease and voice". Os critérios de inclusão foram: idioma em português ou inglês; artigos dos anos 2003-2013; e estudos de intervenção. Adotou-se como critérios de exclusão: os repetidos nas bases de dados; pesquisas com animais. Durante a busca foram localizados 351 artigos, dos quais apenas 18 deles preenchiam os critérios de inclusão adotados no estudo. Os resultados foram apresentados considerando os diferentes tipos de tratamento para a voz na Doença de Parkinson, de acordo com a técnica de intervenção: medicamentoso, cirúrgico e reabilitação, identificando os autores e ano de publicação, características da amostra, o tipo de tratamento, o método utilizado e a conclusão do estudo. Nesta pesquisa observou-se reduzida produção científica no tratamento da voz na doença de Parkinson. A maioria dos artigos abordou as técnicas de tratamento para a voz de alto custo, ou que necessitam de habilitação/certificação no método para a realização da terapia de voz.

ABSTRACT: The aim of this review was to assess the scientific evidences and restrictions of the different kinds of voice treatments in Parkinson's disease. The survey of articles was conducted in the databases PubMed/MEDLINE, SciELO and Lilacs. As a search strategy, combinations with the following descriptors were used: "Parkinson disease and vocal therapy"; "Parkinson disease and speech acoustic"; "Parkinson disease and voice". Inclusion criteria were: Portuguese or English language; articles from 2003-2013; and intervention studies. The following exclusion criteria were adopted: those repeated in the databases; animal research. During the search, 351 articles were found, of which only 18 met the inclusion criteria in the study. The results were presented considering the various types of voice treatment in Parkinson's disease, according to the intervention technique: pharmacological, surgical and rehabilitation, identifying authors and the year of publication, the sample characteristics, the type of treatment, the method used and the conclusion of the study. In this study, it was observed reduced scientific literature for voice treatment in Parkinson's disease. Most articles addressed high-cost treatment techniques for voice, or in need of qualification/certification in the method for carrying out the speech therapy.

RESUMO Nós relatamos o caso de um paciente com 73 anos de idade, diagnosticado com doença de Alzheimer, submetido a 10 sessões diárias de estimulação transcraniana por corrente continua (ETCC). A ETCC foi aplicada sobre o córtex dorsolateral esquerdo como terapêutica adjuvante ao tratamento tradicional que o paciente recebia (medicação anticolinérgica e treino cognitivo). Os dados foram analisados qualitativamente e apresentados em um formato analítico e estruturado. O desempenho foi avaliado através da Alzheimer's Disease Assessment Scale-cognitive subscale, como desfecho primário. Os desfechos secundários incluíram: Neuropsychiatric Inventory, Blessed Dementia Scale e Disability Assessment for Dementia. Os dados obtidos demonstraram que a ETCC teve um efeito estabilizador sobre a função cognitiva geral do paciente e levou ao aumento do desempenho em todos os testes de desfechos secundários. Estes resultados preliminares indicam que a ETCC é uma potencial terapêutica adjuvante para a reabilitação cognitiva na doença de Alzheimer.

ABSTRACT We report the case of a 73-year-old male patient with Alzheimer's disease who underwent 10-daily transcranial direct current stimulation (tDCS) sessions. tDCS was applied over the left dorsolateral prefrontal cortex as an adjuvant to the traditional treatment that the patient was receiving, which consisted of anticholinergic medication and cognitive training. The data were qualitatively analyzed and are presented in an analytic and structured form. The effects on cognitive performance were evaluated using the Alzheimer's Disease Assessment Scale-cognitive subscale as the primary outcome. Secondary outcomes were assessed with a set of tests consisting of the Neuropsychiatric Inventory, the Blessed Dementia Scale and the Disability Assessment for Dementia. The data obtained revealed that the application of tDCS had a stabilizing effect on overall patient cognitive function and led to improved performance on all the secondary outcome tests. These preliminary results indicate that tDCS is a potential adjuvant therapeutic tool for cognitive rehabilitation in Alzheimer's disease .

RESUMONo contexto da interação interpessoal, no qual são utilizados recursos comportamentais como gestos, expressões faciais, postura corporal e modulação de voz, destaca-se o fenômeno da mentira, que é caracterizada pela dissimulação de ideias, sentimentos e emoções. No presente trabalho foi realizado um levantamento teórico acerca da mentira, sendo descritos alguns de seus aspectos comportamentais e neurobiológicos e também analisadas as publicações relacionadas ao tema no Brasil. As implicações do uso de técnicas de avaliação da mentira no âmbito judicial, bem como as crenças infundadas utilizadas em julgamentos são discutidas. A revisão identificou poucos estudos sobre a temática no contexto brasileiro, o que indica a necessidade de ampliação desse campo de investigação no país.

ABSTRACTIn the context of interpersonal interaction, in which behavioral features such as gestures, facial expressions, body posture, and voice modulation are used, there is the phenomenon of lying, which is characterized by the dissimulation of ideas, feelings and emotions. This study carried out a theoretical survey about lying, describing some of its behavioral and neurobiological aspects and analyzing the publications on the theme in Brazil. The implications of the use of lie evaluation techniques in legal contexts, as well as the baseless beliefs used in trials are discussed.The literature review revealed a small number of studies on the subject in the Brazilian context, indicating the need of expanding this research field in the country.

Objective:To explore the temporal mechanism of attention in children with attention deficit hyperactivity disorder (ADHD) and controls using a rapid serial visual presentation (RSVP) task in which two letters (T1 and T2) were presented in close temporal proximity among distractors (attentional blink [AB]).Method:Thirty children aged between 9 and 13 years (12 with ADHD combined type and 18 controls) took part in the study. Both groups performed two kinds of RSVP task. In the single task, participants simply had to identify a target letter (T1), whereas in the dual task, they had to identify a target letter (T1) and a probe letter (T2).Results:The ADHD and control groups were equivalent in their single-task performance. However, in the dual-task condition, there were significant between-group differences in the rate of detection of the probe letter (T2) at lag + 1 and lag + 4. The ADHD group exhibited a larger overall AB compared with controls.Conclusion:Our findings provide support for a link between ADHD and attentional blink.

The present study investigated the mechanisms involved in processing orientation on the frontal and ground planes. The stimuli comprised two yellow circles conceived as the endpoints of a segment and depicted on a black background. In Experiment 1, the observers performed two tasks on both planes (frontal and ground). In Task 1 they were asked to indicate the absolute location of the two endpoints, presented one at a time (successive task). In Task 2 they had to locate the relative position of the endpoints presented simultaneously (simultaneous task). Relative and absolute errors were analyzed according to a cyclopean coordinate system derived from the geometry of the visual scene. These two kinds of errors were studied within the framework of the hypothesis that each kind of task would minimize the error related to its codification. The results showed greater absolute errors in the simultaneous task than in the successive task and greater relative errors in which the successive task seemingly activated a more accurate way of codification of the orientation. In Experiment 2 we controlled the availability of visual depth cues by changing the presentation time (50 and 3000 ms) and viewing conditions (monocular and binocular) in the simultaneous task. The results showed that the precision of orientation judgments was poorer on the ground plane than on the frontal plane, except when the observers used binocular vision. These results suggest that the orientation of a segment, at least on the ground plane, can be conceptualized as a gradient of disparities.

The present study investigated the influence of emotional valence on the spatial stimulus-key location correspondence effect in three experiments using the Affective Spatial Correspondence task (AffSCt). We initially reanalyzed the results of Conde et al. (2011) according to the model proposed by Proctor (2013). In that study, compatible and incompatible responses were chosen according to the participants' team preference. In one block, the volunteers had to press a key on the same side for the Favorite team and on the opposite side for the Rival team. In another block, a reverse code was used. We found that responses were faster for the Favorite-compatible/Rival-incompatible condition (614 ms) compared with the Favorite-incompatible/Rival-compatible condition (691 ms). The same experimental arrangement was replicated in another Brazilian city, and similar results were found. Additionally, we employed non-affective "fake" soccer teams as a control condition, and no mapping-rule effect was observed. Finally, a final experiment that used the same design but different non-affective stimuli (yellow and blue bars) was performed to provide further evidence that the valence effect in the present experimental paradigm only occurs with affective stimuli. As expected, non-affective stimuli did not produce an overall advantage for any mapping rules, corroborating earlier findings with similar mixed designs. The results confirmed the previous findings and validity of the AffSCt as a methodology to investigate the effects of emotional valence on stimulus-response correspondence. However, we are unable to provide a conclusive explanation to support the several hypotheses proposed previously in our paper and by Proctor (2013).

O objetivo deste estudo foi avaliar a percepção das notas musicais RÉ, FÁ, e LÁ em adultos jovens. Participaram do estudo 20 homens e 20 mulheres de 18 a 29 anos, saudáveis, não músicos e não usuários de fármacos ou outras substâncias tóxicas. Realizou-se um teste de discriminação de notas musicais com escolha forçada entre duas alternativas, por meio do qual os participantes escolheram um estímulo previamente apresentado. Comparou-se a frequência de acertos na discriminação das notas musicais em relação ao sexo dos participantes. Encontraram-se diferenças estatisticamente significantes na nota musical Fá, sendo que os homens apresentaram maior quantidade de acertos que as mulheres. Esses resultados encontrados sugerem diferença na percepção das notas musicais para mulheres e homens.

The objective of this study was to evaluate the perception of musical notes D, F, and A in young adults. The study included 20 men and 20 women, aged 18 to 29 years, healthy, non-musicians, and non-users of drugs or other toxic substances. Participants did a two-alternative forced choice discrimination test of musical notes, in which they were asked to select the stimulus that was previously presented. The frequency of correct discrimination of the musical notes was compared between both sexes. Statistically significant differences in the musical note F were found. Men had a higher number of hits than women. These results suggest differences in the perception of musical notes by women and men.

Desenvolveu-se um estudo para avaliar o reconhecimento de expressões faciais em diferentes faixas etárias, com inclusão de grupos compostos por: 1) 21 crianças com idade média de 7,7 anos; 2) 19 adultos jovens com idade média de 20,1 anos; e 3) 9 idosos com idade média de 74,7 anos. Na situação de teste, foi solicitado aos participantes que identificassem expressões faciais de alegria, tristeza, medo e raiva em diferentes intensidades emocionais. Os resultados indicaram que os jovens apresentaram um melhor desempenho no reconhecimento de expressões faciais, quando comparados a crianças e idosos. Crianças apresentaram um desempenho similar aos idosos, apoiando a hipótese de que as capacidades de reconhecimento de expressões faciais aperfeiçoam-se na idade adulta e diminuem na velhice.

The present study evaluated the recognition of facial expressions in different ages, using groups composed of: 1) 21 children with a mean age of 7.7 years; 2) 19 young adults with a mean age of 20.1 years; and 3) 9 elderly people with a mean age of 74.7 years. In the tests, participants were asked to identify facial expressions of happiness, sadness, fear and anger of different emotional intensities. The results indicated that the young adults performed better in recognizing facial expressions when compared to the children and elderly people. The children presented a performance similar to the elderly people, supporting the hypothesis that the ability to recognize facial expressions improves in adulthood and diminishes in old age.

Se ha cuestionado la validez ecológica de expresiones faciales estáticas e intensas en el reconocimiento de emociones. Estudios recientes han propuesto el uso de estímulos de expresiones faciales compatibles con las condiciones naturales de interacción social en las que hay movimiento y variaciones en la intensidad emocional. En esta investigación se comparó el reconocimiento de expresiones faciales estáticas y dinámicas de alegría, miedo, rabia y tristeza, presentadas en cuatro intensidades emocionales (25, 50, 75 y 100%). El estudio incluyó a veinte voluntarios (nueve mujeres y once hombres) con edades comprendidas entre 19 y 31 años. El experimento consistió de dos sesiones, en las cuales los participantes tenían que identificar la emoción de expresiones faciales estáticas (fotografías) y dinámicas (videos) presentadas en la pantalla del ordenador. Los promedios de aciertos fueron sometidos a una Anova para medidas repetidas de modelo: 2 sexos x [2 condiciones x 4 expresiones x 4 intensidades]. Se observó una ventaja para el reconocimiento de expresiones dinámicas de alegría y miedo frente a los estímulos estáticos equivalentes (p < .05). El análisis de las interacciones mostró que las expresiones con intensidad de un 25% fueron reconocidas mejor en la condición dinámica (p < .05). La adición de movimiento contribuyó para el reconocimiento de emociones en los participantes masculinos (p < .05). Se concluyó que el efecto del movimiento varía con el tipo de emoción, intensidad de expresión y sexo del participante. Estos resultados apoyan la hipótesis de que los estímulos dinámicos tienen más validez ecológica y pertinencia en la investigación de las emociones.

Ecological validity of static and intense facial expressions in emotional recognition has been questioned. Recent studies have recommended the use of facial stimuli more compatible to the natural conditions of social interaction, which involves motion and variations in emotional intensity. In this study, we compared the recognition of static and dynamic facial expressions of happiness, fear, anger and sadness, presented in four emotional intensities (25%, 50%, 75% and 100%). Twenty volunteers (9 women and 11 men), aged between 19 and 31 years, took part in the study. The experiment consisted of two sessions in which participants had to identify the emotion of static (photographs) and dynamic (videos) displays of facial expressions on the computer screen. The mean accuracy was submitted to an Anova for repeated measures of model: 2 sexes x [2 conditions x 4 expressions x 4 intensities]. We observed an advantage for the recognition of dynamic expressions of happiness and fear compared to the static stimuli (p < .05). Analysis of interactions showed that expressions with intensity of 25% were better recognized in the dynamic condition (p < .05). The addition of motion contributes to improve recognition especially in male participants (p < .05). We concluded that the effect of the motion varies as a function of the type of emotion, intensity of the expression and sex of the participant. These results support the hypothesis that dynamic stimuli have more ecological validity and are more appropriate to the research with emotions.

Tem sido questionada a validade ecológica de expressões faciais estáticas e intensas no reconhecimento de emoções. Estudos recentes têm proposto o uso de estímulos faciais compatíveis com as condições naturais de interação social em que há movimento e variações na intensidade emocional. No presente estudo, foi comparado o reconhecimento de expressões faciais estáticas e dinâmicas de alegria, medo, raiva e tristeza, apresentadas em quatro intensidades emocionais (25%, 50%, 75% e 100%). Participaram do estudo 20 voluntários (9 mulheres e 11 homens), com idade variando entre 19 e 31 anos. O experimento foi composto por duas sessões, nas quais os participantes deveriam identificar a emoção de expressões faciais estáticas (fotografias) e dinâmicas (vídeos) apresentadas na tela do computador. As médias de acerto foram submetidas a uma Anova para medidas repetidas de modelo: 2 sexos x [2 condições x 4 expressões x 4 intensidades]. Foi observada uma vantagem para o reconhecimento das expressões dinâmicas de alegria e medo em comparação com as equivalentes estáticas (p < .05). A análise das interações mostrou que as expressões com intensidade de 25% foram mais bem reconhecidas na condição dinâmica (p < .05). A adição do movimento contribui para melhorar o reconhecimento das emoções nos participantes do sexo masculino (p < .05). Concluí-se que o efeito do movimento varia em função do tipo da emoção, intensidade da expressão e sexo do participante. Tais resultados sustentam a hipótese de que estímulos dinâmicos possuem maior validade ecológica e adequação à pesquisa com emoções.