Abstract Objective Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and social interaction and by restricted and repetitive patterns of behavior. Some studies have shown that substances derived from Cannabis sativa improve the quality of life of children with ASD without causing serious adverse effects, thus providing an alternative therapeutic option. The objective of this study was to evaluate the efficacy and safety of a cannabis extract rich in cannabidiol (CBD) in children with ASD. Methods In this randomized, double-blind, placebo-controlled clinical trial, 60 children, aged from 5 to 11 years, were selected and divided into two groups: the treatment group, which received the CBD-rich cannabis extract, and the control group, which received the placebo. They both used their respective products for a period of 12 weeks. Statistical analysis was done by two-factor mixed analysis of variance (two-way ANOVA). Results Significant results were found for social interaction (F1,116 = 14.13, p = 0.0002), anxiety (F1,116 = 5.99, p = 0.016), psychomotor agitation (F1,116 = 9.22, p = 0.003), number of meals a day (F1,116 = 4.11, p = 0.04), and concentration (F1,48 = 6.75, p = 0.01), the last of which was only significant in mild ASD cases. Regarding safety, it was found that only three children in the treatment group (9.7%) had adverse effects, namely dizziness, insomnia, colic, and weight gain. Conclusion CBD-rich cannabis extract was found to improve one of the diagnostic criteria for ASD (social interaction), as well as features that often co-exist with ASD, and to have few serious adverse effects. (ASD behavior effects option CBD (CBD randomized doubleblind, doubleblind double blind, blind double-blind placebocontrolled placebo controlled trial 6 1 years groups CBDrich weeks twofactor factor twoway way ANOVA. ANOVA . ANOVA) F1,116 F1116 F F1 116 (F1,11 1413 14 13 14.13 0.0002, 00002 0.0002 , 0 0002 0.0002) 599 99 5.99 0.016, 0016 0.016 016 0.016) 922 9 22 9.22 0.003, 0003 0.003 003 0.003) 411 4 4.11 0.04, 004 0.04 04 0.04) F1,48 F148 48 (F1,4 675 75 6.75 0.01, 001 0.01 01 0.01) cases 9.7% 97 7 (9.7% dizziness insomnia colic gain interaction, interaction) coexist co exist F1,11 F111 (F1,1 141 14.1 0000 0.000 000 59 5.9 92 2 9.2 0.00 00 41 4.1 0.0 F1,4 F14 (F1, 67 6.7 9.7 (9.7 F1,1 F11 14. 5. 9. 4. 0. F1, (F1 6. (9. (F (9 (

RESUMO JUSTIFICATIVA E OBJETIVOS: Diante do contexto da pandemia ocasionada pela COVID-19, os indivíduos com dor crônica, como na fibromialgia, experimentaram o impacto do isolamento social. Assim, considerando a escassez de estudos que contemplem avaliações iniciais de mulheres com fibromialgia antes do período de pandemia e que as comparem com o momento de contexto pandêmico, objetivou-se analisar as possíveis repercussões da pandemia decorrentes da COVID-19 em sintomas psicológicos, qualidade de vida e dor. MÉTODOS: Trata-se de uma pesquisa observacional descritiva, longitudinal, com abordagem exploratória e quantitativa. A amostra foi composta por 15 mulheres com fibromialgia a pelo menos três meses, com idades entre 43 e 55 anos e com nível de dor acima de quatro na Escala Analógica Visual (EAV). Foram utilizados o Questionário Sociodemográfico e Clínico, o Inventário Beck de Ansiedade (IBA), o Inventário Beck de Depressão (IBD) e o Health Assessment Questionnaire (HAQ). RESULTADOS: Em média, a intensidade da dor durante o isolamento social (8,40±1,50) e o nível de ansiedade (29,80±13,97) foram maiores do que antes da pandemia (6,06±1,62, p=0,001) e (22,33±9,69, p=0,006), respectivamente. Ou seja, as participantes mostraram maiores níveis de ansiedade e dor durante o período de isolamento social. A média dos sintomas depressivos e qualidade de vida diferiram minimamente, não demostrando significância estatística, com p=0,94 e p=0,46, respectivamente. CONCLUSÃO: A pandemia da COVID-19 pode ter contribuído para o aumento das queixas de dor e ansiedade durante o período pandêmico. Entretanto, outras variáveis não controladas podem ter infuenciado nesse resultado, como resiliência e suporte familiar, por exemplo.

ABSTRACT BACKGROUND AND OBJECTIVES: In the context of the pandemic caused by COVID-19, individuals with chronic pain, as in fibromyalgia, experienced the impact of social isolation. Tus, considering the scarcity of studies that contemplate initial assessments of women with fibromyalgia before the pandemic period and that compare them with the pandemic context moment, the objective was to analyze the possible repercussions of the pandemic resulting from COVID-19 on the psychological symptoms, quality of life and pain. METHODS: A descriptive, cross-sectional, observational research with an exploratory and quantitative approach. Te sample was composed of 15 women with fibromyalgia for at least three months, aged between 43 and 55 years and with pain level above four on the Visual Analog Scale (VAS). Te Sociodemographic and Clinical Questionnaire, the Beck Anxiety Inventory (BAI), the Beck Depression Inventory (BDI), and the Health Assessment Questionnaire (HAQ) were used. RESULTS: On average, pain intensity during social isolation (8,40±1,50) and anxiety level (29,80±13,97) were higher than before the pandemic (6,06±1,62, p=0,001) and (22,33±9,69, p=0,006), respectively. In other words, the participants showed higher levels of anxiety and pain during the period of social isolation. Mean depressive symptoms and quality of life difered minimally, showing no statistical significance, with p=0.94 and p=0.46, respectively. CONCLUSION: The COVID-19 pandemic may have contributed to the increase in pain and anxiety levels during the pandemic period. However, other uncontrolled variables may have infuenced this result, such as resilience and family support, for example.

RESUMO JUSTIFICATIVA E OBJETIVOS: Diante do contexto da pandemia ocasionada pela COVID-19, os indivíduos com dor crônica, como na fibromialgia, experimentaram o impacto do isolamento social. Assim, considerando a escassez de estudos que contemplem avaliações iniciais de mulheres com fibromialgia antes do período de pandemia e que as comparem com o momento de contexto pandêmico, objetivou-se analisar as possíveis repercussões da pandemia decorrentes da COVID-19 em sintomas psicológicos, qualidade de vida e dor. MÉTODOS: Trata-se de uma pesquisa observacional descritiva, longitudinal, com abordagem exploratória e quantitativa. A amostra foi composta por 15 mulheres com fibromialgia a pelo menos três meses, com idades entre 43 e 55 anos e com nível de dor acima de quatro na Escala Analógica Visual (EAV). Foram utilizados o Questionário Sociodemográfico e Clínico, o Inventário Beck de Ansiedade (IBA), o Inventário Beck de Depressão (IBD) e o Health Assessment Questionnaire (HAQ). RESULTADOS: Em média, a intensidade da dor durante o isolamento social (8,40±1,50) e o nível de ansiedade (29,80±13,97) foram maiores do que antes da pandemia (6,06±1,62, p=0,001) e (22,33±9,69, p=0,006), respectivamente. Ou seja, as participantes mostraram maiores níveis de ansiedade e dor durante o período de isolamento social. A média dos sintomas depressivos e qualidade de vida diferiram minimamente, não demostrando significância estatística, com p=0,94 e p=0,46, respectivamente. CONCLUSÃO: A pandemia da COVID-19 pode ter contribuído para o aumento das queixas de dor e ansiedade durante o período pandêmico. Entretanto, outras variáveis não controladas podem ter infuenciado nesse resultado, como resiliência e suporte familiar, por exemplo.

ABSTRACT BACKGROUND AND OBJECTIVES: In the context of the pandemic caused by COVID-19, individuals with chronic pain, as in fibromyalgia, experienced the impact of social isolation. Tus, considering the scarcity of studies that contemplate initial assessments of women with fibromyalgia before the pandemic period and that compare them with the pandemic context moment, the objective was to analyze the possible repercussions of the pandemic resulting from COVID-19 on the psychological symptoms, quality of life and pain. METHODS: A descriptive, cross-sectional, observational research with an exploratory and quantitative approach. Te sample was composed of 15 women with fibromyalgia for at least three months, aged between 43 and 55 years and with pain level above four on the Visual Analog Scale (VAS). Te Sociodemographic and Clinical Questionnaire, the Beck Anxiety Inventory (BAI), the Beck Depression Inventory (BDI), and the Health Assessment Questionnaire (HAQ) were used. RESULTS: On average, pain intensity during social isolation (8,40±1,50) and anxiety level (29,80±13,97) were higher than before the pandemic (6,06±1,62, p=0,001) and (22,33±9,69, p=0,006), respectively. In other words, the participants showed higher levels of anxiety and pain during the period of social isolation. Mean depressive symptoms and quality of life difered minimally, showing no statistical significance, with p=0.94 and p=0.46, respectively. CONCLUSION: The COVID-19 pandemic may have contributed to the increase in pain and anxiety levels during the pandemic period. However, other uncontrolled variables may have infuenced this result, such as resilience and family support, for example.

Abstract Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and social interaction, associated with the presence of restricted and repetitive patterns of behavior, interests, or activities. Cannabis has been used to alleviate symptoms associated with ASD. Method We carried out a systematic review of studies that investigated the clinical effects of cannabis and cannabinoid use on ASD, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA checklist). The search was carried out in four databases: MEDLINE/PubMed, Scientific Electronic Library Online (SciELO), Scopus, and Web of Science. No limits were established for language during the selection process. Nine studies were selected and analyzed. Results Some studies showed that cannabis products reduced the number and/or intensity of different symptoms, including hyperactivity, attacks of self-mutilation and anger, sleep problems, anxiety, restlessness, psychomotor agitation, irritability, aggressiveness perseverance, and depression. Moreover, they found an improvement in cognition, sensory sensitivity, attention, social interaction, and language. The most common adverse effects were sleep disorders, restlessness, nervousness and change in appetite. Conclusion Cannabis and cannabinoids may have promising effects in the treatment of symptoms related to ASD, and can be used as a therapeutic alternative in the relief of those symptoms. However, randomized, blind, placebo-controlled clinical trials are necessary to clarify findings on the effects of cannabis and its cannabinoids in individuals with ASD. Systematic review registration International Prospective Register of Systematic Reviews (PROSPERO), code 164161.

Abstract Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and social interaction, associated with the presence of restricted and repetitive patterns of behavior, interests, or activities. Cannabis has been used to alleviate symptoms associated with ASD. Method We carried out a systematic review of studies that investigated the clinical effects of cannabis and cannabinoid use on ASD, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA checklist). The search was carried out in four databases: MEDLINE/PubMed, Scientific Electronic Library Online (SciELO), Scopus, and Web of Science. No limits were established for language during the selection process. Nine studies were selected and analyzed. Results Some studies showed that cannabis products reduced the number and/or intensity of different symptoms, including hyperactivity, attacks of self-mutilation and anger, sleep problems, anxiety, restlessness, psychomotor agitation, irritability, aggressiveness perseverance, and depression. Moreover, they found an improvement in cognition, sensory sensitivity, attention, social interaction, and language. The most common adverse effects were sleep disorders, restlessness, nervousness and change in appetite. Conclusion Cannabis and cannabinoids may have promising effects in the treatment of symptoms related to ASD, and can be used as a therapeutic alternative in the relief of those symptoms. However, randomized, blind, placebo-controlled clinical trials are necessary to clarify findings on the effects of cannabis and its cannabinoids in individuals with ASD. Systematic review registration International Prospective Register of Systematic Reviews (PROSPERO), code 164161.

A fibromialgia é uma condição em que há dor crônica generalizada, na qual é comum a presença de comorbidades, aumentando o sofrimento e a piora da qualidade de vida. Assim, necessita-se compreender suas comorbidades para facilitar seu diagnóstico e tratamento adequados. Objetivou-se realizar uma análise bibliométrica das produções científicas sobre comorbidades associadas à fibromialgia. Realizou-se busca nas bases de dados da PUBMED, LILACS e SciELO, com as palavras-chave “Fibromyalgia” AND “Comorbidity”. Incluíram-se estudos relevantes e relacionados ao tema, publicados em inglês, espanhol e português, estudos de caso e série de casos, caso-controle, coorte, estudos pilotos e ensaios clínicos disponibilizados na íntegra, entre 2008 e 2018. Excluíram-se os artigos duplicados nas bases de dados, os que se referiam a outras patologias como doença de base e os relacionados a modelos animais. Observou-se que as comorbidades da fibromialgia mais estudadas nos últimos 10 anos foram as doenças psiquiátricas, como ansiedade, depressão e transtorno bipolar, seguidas pelo distúrbio do sono. Os Estados Unidos lideraram em número de pesquisas sobre comorbidades da fibromialgia. A maioria dos estudos recebeu financiamento e o auge das publicações ocorreu em 2013 e 2016. A maioria das pesquisas correspondeu aos estudos de caso-controle e o periódico que mais publicou sobre essa temática foi a Clinical and Experimental Rheumatology. O Brasil ainda possui poucas publicações nessa área, o que impossibilitou uma análise comparativa em relação ao panorama internacional. Desperta-se, assim, a necessidade de maiores incentivos a estudos nacionais sobre as comorbidades presentes na população brasileira com fibromialgia.

Fibromyalgia is a condition in which there is widespread chronic pain, in which the presence of comorbidities is common, increasing suffering and worsening quality of life. Thus, it is necessary to understand its comorbidities to facilitate its proper diagnosis and treatment. The objective was to carry out a bibliometric analysis of scientific productions on comorbidities associated with fibromyalgia. A search was conducted in the databases of PUBMED, LILACS and SciELO, with the keywords “Fibromyalgia” AND “Comorbidity”. Relevant and related studies published in English, Spanish and Portuguese, case studies and case series, case-control, cohort, pilot studies and clinical trials made available in full, between 2008 and 2018 were included. Duplicate articles in the databases, those referring to other pathologies such as underlying disease and those related to animal models were excluded. We found that the most studied comorbidities of fibromyalgia in the last 10 years were psychiatric disorders, such as anxiety, depression and bipolar disorder, followed by sleep disorders. The United States has led in number of studies on fibromyalgia comorbidities. Most of the studies received funding and the peak of publications occurred in 2013 and 2016. Most of the research corresponded to case-control studies and the journal that most published on this subject was Clinical and Experimental Rheumatology. Brazil still has few publications in this area, which prevented a comparative analysis in relation to the international panorama. Thus, there is a need for greater incentives for national studies on the comorbidities present in the Brazilian population with fibromyalgia.

Abstract Social anxiety disorder (SAD) is characterized by the fear of being judged negatively in social situations. Eye-tracking techniques have been prominent among the methods used in recent decades to investigate emotional processing in SAD. This study offers a systematic review of studies on eye-tracking patterns in individuals with SAD and controls in facial emotion recognition tasks. Thirteen articles were selected from the consulted databases. It was observed that the subjects with SAD exhibited hypervigilance-avoidance in response to emotions, primarily in the case of negative expressions. There was avoidance of conspicuous areas of the face, particularly the eyes, during observations of negative expressions. However, this hypervigilance did not occur if the stimulus was presented in virtual reality. An important limitation of these studies is that they use only static expressions, which can reduce the ecological validity of the results.

Resumen Estudios han demostrado que la depresión y la ansiedad están asociados a cambios en el reconocimiento de la expresión facial. En la presente investigación, una muestra no clínica ha sido evaluada con respecto a la ansiedad rasgo y estado y los síntomas de depresión. En la tarea experimental, los participantes evaluaran expresiones faciales de alegría, ira, tristeza y miedo, presentadas en cuatro intensidades (25, 50, 75 y 100%), y el rostro neutro. Los resultados mostraron que la ansiedad rasgo se asoció con un mejor reconocimiento de la ira, miedo y alegría. Para la depresión, sólo se encontraron diferencias entre los grupos para la atribución emocional a rostros neutros, en el que los participantes que puntuaran alto en depresión eran más propensos a atribuir miedo a rostros neutros. Los resultados indican una mejora del reconocimiento de la alegría, ira y miedo en la ansiedad rasgo, mientras que los síntomas de depresión y ansiedad estado están asociados a cambios en la evaluación de rostros neutros en individuos no clínicos.

Abstract Previous studies have shown that depression and anxiety are associated to changes in the recognition of facial expression. In the present research, a non-clinical sample was evaluated with respect to trait and state anxiety and depression symptoms. In the experimental task, participants evaluated facial expressions of happiness, anger, sadness, and fear, presented at four intensities (25, 50, 75, and 100%), as well as the neutral face. Results showed that the trait anxiety was associated with a better recognition of anger, fear, and happiness. For depression, we only found differences between groups for emotional attribution to neutral faces, in which participants scoring high in depression were more likely to attribute fear to neutral faces. Findings indicate an improvement of the recognition of happiness, anger, and fear in trait anxiety, whereas symptoms of depression and state anxiety were associated to changes in the evaluation of neutral faces in non-clinical individuals.

In the aging process, changes in perception and cognition may lead to losses in the recognition of facial emotions. In this study, we carried out, according to PRISMA guidelines, a systematic review of recent studies that evaluated the perception and facial emotion recognition in the elderly without pathologies. Searches occurred in the electronic databases: MEDLINE, PsycoINFO and Web of Science, being selected 22 articles published between 2009 and 2016. In general, we found that elderly show a decline in emotion recognition, mainly for negative emotions. These results can be explained by the structural theory as well as by theory of the socioemotional selectivity. The results have important implications inasmuch as they indicate the relevance of cognitive assessment and use of more ecological stimuli in emotion recognition tasks in elderly.

No processo de envelhecimento, alterações na percepção e na cognição podem gerar prejuízos no reconhecimento de emoções faciais. No presente trabalho, foi realizada uma revisão sistemática, de acordo com as diretrizes do PRISMA, de estudos recentes que avaliaram a percepção e o reconhecimento facial de emoções em idosos sem patologias. As bases eletrónicas de dados pesquisadas foram: MEDLINE, PsycoINFO e Web of Science, sendo selecionados 22 artigos publicados entre 2009 e 2016. De um modo geral, verificou-se que os idosos apresentaram um declínio no reconhecimento de emoções, principalmente para as emoções negativas. Tais resultados podem ser explicados tanto pela teoria estrutural, quanto pela teoria da seletividade socioemocional. Os resultados têm importantes implicações na medida em que sinalizam a relevância da avaliação cognitiva e do uso de estímulos mais ecológicos nas tarefas de reconhecimento emocional em idosos.

The ability to recognize emotions in faces is essential to human interaction and occurs since childhood. Hypothesis: research using the morphing technique assume that children require greater or lesser intensity of emotional expression to perceive it. Objective: to examine the emotional recognition of faces in childhood, using a task with emotional intensity variation. Method: it was applied a Test of Facial Emotion Recognition for Children to 28 children between 7 and 11 years, of both sexes, which presented 168 faces manipulated by the morphing technique, of the six basic emotions. Results: age as a trend growth of the likelihood of success at the task; more right answers for happiness and worst performances for fear; and the emotional intensity increasing at 42% the chance of success by every unit of intensity. Conclusion: these findings are relevant because they show the recognition of emotions at different levels as a more sensitive method.

Resumo Em geral, a experiência de proporcionar assistência e lidar com as complicações da pessoa com doença de Alzheimer coloca os cuidadores em uma situação de alto risco, vulnerabilidade e estresse, causando sérios problemas físicos e emocionais. Entretanto, existem cuidadores com uma mentalidade resiliente que os leva a experimentar e expressar sentimentos positivos e uma menor sobrecarga associada ao cuidado. Esta experiência positiva acontece porque percebem o processo de cuidar como menos prejudicial. Enfrentam a situação de cuidado com uma atitude mais positiva e são capazes de resistir e manter um funcionamento adaptativo. O objetivo desta revisão narrativa da literatura foi indicar a necessidade de se desenvolver programas de intervenção para o cuidador, com base em modelos salutogênicos, de resiliência, resistência e crescimento pessoal, para promover os recursos positivos da pessoa, da família e da comunidade.

Abstract In general, the experience of providing assistance to and dealing with the complications experienced by a person with Alzheimer's disease puts caregivers in a situation of high risk, vulnerability, and stress, causing serious physical and emotional problems. However, some caregivers adopt a resilient mindset, which helps them to experience and express positive feelings as well as lower their burden in relation to the care. This positive experience occurs because caregivers perceive the process of caring as less adverse. They face the situation of care with a more positive mindset and are able to resist and maintain adaptive functioning. The objective of the present narrative literature review was to emphasize the need to develop intervention programs for caregivers based on salutogenic models of resilience, resistance, and personal growth to promote positive individual, family, and community resources.

Resumen En general, la experiencia de proporcionar asistencia y lidiar con las complicaciones del enfermo de Alzheimer sitúa a los cuidadores en una situación de alto riesgo, vulnerabilidad y estrés, ocasionando importantes problemas físicos y emocionales en muchos familiares. En cambio, existen cuidadores que disponen de una mentalidad resiliente que les protege y lleva a experimentar sentimientos positivos y experimentar menor sobrecarga. Esta experiencia positiva sucede porque interpretan el proceso de cuidado como menos negativo, afrontan la situación con una actitud positiva y son capaces de resistir y mantener un funcionamiento adaptativo. El objetivo de esta revisión narrativa da literatura fue señalar la necesidad de desarrollar programas de intervenciones centradas en el cuidador que promuevan los modelos salutogénicos, de resistencia, resistencia y crecimiento personal, para potenciar los recursos positivos del cuidador, de la familia y de la comunidad.

RESUMO: O objetivo desta revisão de literatura foi verificar as evidências científicas e restrições dos diferentes tipos de tratamentos para voz na Doença de Parkinson. O levantamento dos artigos foi realizado nas bases de dados PubMed/MEDLINE, SciELO e Lilacs. Utilizou-se como estratégia de busca as combinações com os seguintes descritores: "Parkinson disease and vocal therapy"; "Parkinson disease and speech acoustic"; "Parkinson disease and voice". Os critérios de inclusão foram: idioma em português ou inglês; artigos dos anos 2003-2013; e estudos de intervenção. Adotou-se como critérios de exclusão: os repetidos nas bases de dados; pesquisas com animais. Durante a busca foram localizados 351 artigos, dos quais apenas 18 deles preenchiam os critérios de inclusão adotados no estudo. Os resultados foram apresentados considerando os diferentes tipos de tratamento para a voz na Doença de Parkinson, de acordo com a técnica de intervenção: medicamentoso, cirúrgico e reabilitação, identificando os autores e ano de publicação, características da amostra, o tipo de tratamento, o método utilizado e a conclusão do estudo. Nesta pesquisa observou-se reduzida produção científica no tratamento da voz na doença de Parkinson. A maioria dos artigos abordou as técnicas de tratamento para a voz de alto custo, ou que necessitam de habilitação/certificação no método para a realização da terapia de voz.

ABSTRACT: The aim of this review was to assess the scientific evidences and restrictions of the different kinds of voice treatments in Parkinson's disease. The survey of articles was conducted in the databases PubMed/MEDLINE, SciELO and Lilacs. As a search strategy, combinations with the following descriptors were used: "Parkinson disease and vocal therapy"; "Parkinson disease and speech acoustic"; "Parkinson disease and voice". Inclusion criteria were: Portuguese or English language; articles from 2003-2013; and intervention studies. The following exclusion criteria were adopted: those repeated in the databases; animal research. During the search, 351 articles were found, of which only 18 met the inclusion criteria in the study. The results were presented considering the various types of voice treatment in Parkinson's disease, according to the intervention technique: pharmacological, surgical and rehabilitation, identifying authors and the year of publication, the sample characteristics, the type of treatment, the method used and the conclusion of the study. In this study, it was observed reduced scientific literature for voice treatment in Parkinson's disease. Most articles addressed high-cost treatment techniques for voice, or in need of qualification/certification in the method for carrying out the speech therapy.

RESUMO Nós relatamos o caso de um paciente com 73 anos de idade, diagnosticado com doença de Alzheimer, submetido a 10 sessões diárias de estimulação transcraniana por corrente continua (ETCC). A ETCC foi aplicada sobre o córtex dorsolateral esquerdo como terapêutica adjuvante ao tratamento tradicional que o paciente recebia (medicação anticolinérgica e treino cognitivo). Os dados foram analisados qualitativamente e apresentados em um formato analítico e estruturado. O desempenho foi avaliado através da Alzheimer's Disease Assessment Scale-cognitive subscale, como desfecho primário. Os desfechos secundários incluíram: Neuropsychiatric Inventory, Blessed Dementia Scale e Disability Assessment for Dementia. Os dados obtidos demonstraram que a ETCC teve um efeito estabilizador sobre a função cognitiva geral do paciente e levou ao aumento do desempenho em todos os testes de desfechos secundários. Estes resultados preliminares indicam que a ETCC é uma potencial terapêutica adjuvante para a reabilitação cognitiva na doença de Alzheimer.

ABSTRACT We report the case of a 73-year-old male patient with Alzheimer's disease who underwent 10-daily transcranial direct current stimulation (tDCS) sessions. tDCS was applied over the left dorsolateral prefrontal cortex as an adjuvant to the traditional treatment that the patient was receiving, which consisted of anticholinergic medication and cognitive training. The data were qualitatively analyzed and are presented in an analytic and structured form. The effects on cognitive performance were evaluated using the Alzheimer's Disease Assessment Scale-cognitive subscale as the primary outcome. Secondary outcomes were assessed with a set of tests consisting of the Neuropsychiatric Inventory, the Blessed Dementia Scale and the Disability Assessment for Dementia. The data obtained revealed that the application of tDCS had a stabilizing effect on overall patient cognitive function and led to improved performance on all the secondary outcome tests. These preliminary results indicate that tDCS is a potential adjuvant therapeutic tool for cognitive rehabilitation in Alzheimer's disease .

RESUMONo contexto da interação interpessoal, no qual são utilizados recursos comportamentais como gestos, expressões faciais, postura corporal e modulação de voz, destaca-se o fenômeno da mentira, que é caracterizada pela dissimulação de ideias, sentimentos e emoções. No presente trabalho foi realizado um levantamento teórico acerca da mentira, sendo descritos alguns de seus aspectos comportamentais e neurobiológicos e também analisadas as publicações relacionadas ao tema no Brasil. As implicações do uso de técnicas de avaliação da mentira no âmbito judicial, bem como as crenças infundadas utilizadas em julgamentos são discutidas. A revisão identificou poucos estudos sobre a temática no contexto brasileiro, o que indica a necessidade de ampliação desse campo de investigação no país.

ABSTRACTIn the context of interpersonal interaction, in which behavioral features such as gestures, facial expressions, body posture, and voice modulation are used, there is the phenomenon of lying, which is characterized by the dissimulation of ideas, feelings and emotions. This study carried out a theoretical survey about lying, describing some of its behavioral and neurobiological aspects and analyzing the publications on the theme in Brazil. The implications of the use of lie evaluation techniques in legal contexts, as well as the baseless beliefs used in trials are discussed.The literature review revealed a small number of studies on the subject in the Brazilian context, indicating the need of expanding this research field in the country.

Objective:To explore the temporal mechanism of attention in children with attention deficit hyperactivity disorder (ADHD) and controls using a rapid serial visual presentation (RSVP) task in which two letters (T1 and T2) were presented in close temporal proximity among distractors (attentional blink [AB]).Method:Thirty children aged between 9 and 13 years (12 with ADHD combined type and 18 controls) took part in the study. Both groups performed two kinds of RSVP task. In the single task, participants simply had to identify a target letter (T1), whereas in the dual task, they had to identify a target letter (T1) and a probe letter (T2).Results:The ADHD and control groups were equivalent in their single-task performance. However, in the dual-task condition, there were significant between-group differences in the rate of detection of the probe letter (T2) at lag + 1 and lag + 4. The ADHD group exhibited a larger overall AB compared with controls.Conclusion:Our findings provide support for a link between ADHD and attentional blink.