RESUMO O objetivo deste estudo é descrever o efeito de um preenchedor de ácido hialurônico em lábios finos, avaliando a distribuição do material e sua relação com a vascularização tecidual bem como a efetividade da estruturação da forma e volume tecidual através dos resultados imediatos e sua longevidade após o período de 10 meses. Participou deste estudo uma mulher caucasiana, 40 anos de idade, com queixa de lábios finos, que nunca havia feito qualquer procedimento clínico ou cirúrgico nos lábios e sem qualquer alteração sistêmica. Foi realizado análise da vascularização labial e distribuição do material preenchedor nos tecidos através de imagens de ultrassom. Também foram analisados a adequação do volume, contorno, hidratação dos lábios e satisfação da paciente. Para se atingir o perfil labial desejado utilizou-se 3 ml do material preenchedor ao longo de 4 sessões. Terapia com toxina botulínica foi associada para o controle das forças musculares depressoras do ângulo da boca, orbicular bucal e ponta do nariz. Uma pequena quantidade de material preenchedor foi usada na ponta do nariz para a harmonia do perfil facial. Lábios finos exigem maiores volumes de material preenchedor considerados seguros e efetivos desde que se monitore a vascularização para a decisão do melhor plano de inserção do material preenchedor. A conjugação com terapias complementares como uso da toxina botulínicas pode ser indicada para a efetividade do contorno e forma deste padrão labial. 1 meses caucasiana idade sistêmica ultrassom paciente utilizouse utilizou sessões boca facial

ABSTRACT The goal of this study is to describe the effect of hyaluronic acid filler on thin lips, evaluating the distribution of the material and its relationship with tissue vascularization, as well as the effectiveness of structuring tissue shape and volume through the immediate clinical results achieved. In addition, this study observes the longevity of the results for a period of 10 months after performing this intervention on the lips. Methodology: A healthy 40-year-old Caucasian woman, complaining of thin lips and who had never undergone clinical or surgical procedures on her lips, participated in this study. An analysis of the lip vascularization and distribution of the filler material in the tissues was carried out using ultrasound images. The adequacy of volume, contour, lip hydration and patient satisfaction were also analyzed. Results: To achieve the desired lip profile, 3 ml of filler material was used throughout 4 sessions. Botulinum toxin therapy was applied to control the depressant muscle forces of the angle of the mouth, the orbicularis oris muscle, and the tip of the nose. A small amount of filler material was used at the tip of the nose to harmonize the facial profile. Conclusions: Thin lips required larger volumes of filler material, which was considered safe and effective if the vascularization is monitored to decide on the best insertion plan for the filler material. A combination with complementary therapies, such as the use of botulinum toxin, may be recommended for the effectiveness of the contour and shape of this lip pattern. achieved addition 1 Methodology 40yearold yearold 40 year old woman images analyzed Results profile sessions mouth Conclusions therapies pattern

Abstract The present study aims to evaluate the longitudinal effects of induced experimental infections in gnotoxenic animals on the expression of inflammatory chemokines and their receptors in periradicular tissues. The null hypothesis tested was that Enterococcus faecalis and Fusobacterium nucleatum had no effect on CCR5, CCL5, CXCL10, CCL2/MCP-1, CXCR2 and CCR1 expression. Two groups of five animals (n = 5) aged between 8 and 12 weeks were used in this study. The animals were anaesthetized, and coronary access was performed in the first molar on the right and left sides. Microorganisms were inoculated into the left molar, and the right molar was sealed without contamination to function as a control. Animals were sacrificed 7 and 14 days after infection, and periapical tissues were collected. The cytokine mRNA expression levels were assessed using real-time PCR. The chemokine mRNA expression levels demonstrated that the experimental infection was capable of inducing increased chemokine expression on day 7 compared to that on day 14, except for CCR5 and CCL5, which showed no changes. The gnotoxenic animal model proved to be effective and allowed evaluation of the immune response against a known infection. Additionally, this study demonstrates that gene expression of chemokines and their receptors against the experimental infection preferentially prevailed during the initial phase of induction of the periradicular alteration (i.e., on day 7 post-infection).