Abstract Background Biomarkers related to the pathogenesis of atrial fibrillation (AF) have attracted the attention of experts. One of these recently studied biomarkers is Fetuin-A. Objectives This study aimed to evaluate the relationship between serum Fetuin-A levels and AF. Methods This study used the convenience sampling method, based on inclusion criteria and consent to participate in the study. The Shapiro-Wilk test was used to confirm the normal distribution of all continuous variables. Categorical variables were presented using absolute and relative frequencies. Both groups (48 patients with AF and 47 controls) were compared in terms of biochemical, hematological, and echocardiographic findings and Fetuin-A. the Chi-square or Fisher's exact test were used to compare groups concerning categorical variables. Continuous variables were compared using the independent samples t-test. P<0.05 was considered statistically significant. Results Serum Fetuin-A values increased in AF patients when compared to the controls (544±49 μg/mL versus 484±46 μg/mL, p=0.001). Moreover, Fetuin-A level was independently associated with AF — AOR = 0.978, 95%; confidence interval (CI) 0.969-988, p < 0.001. The cut-off values in Fetuin-A levels in patients with AF were >511.80 μg/mL with a sensitivity of 75% and a specificity of 73% — area under the curve (AUC) = 0.804, 95% CI = 0.715 - 0.892. Conclusions According to this study, there was a relationship between serum Fetuin-A levels and AF, regardless of conventional cardiovascular risk factors. Therefore, Fetuin-A may play a role in the pathophysiology of AF. Prospectively designed cohort studies are necessary to assess whether or not the results can be generalized for other populations. (AF experts FetuinA. FetuinA Fetuin A. A method ShapiroWilk Shapiro Wilk frequencies 48 (4 4 biochemical hematological Chisquare Chi square Fishers Fisher s ttest. ttest t test. t-test P005 P 0 05 P<0.0 significant 544±49 54449 544 49 (544±4 μgmL μg mL 48446 484 46 484±4 p=0.001. p0001 p=0.001 . 001 p=0.001) Moreover 0978 978 0.978 95 (CI 0.969988, 0969988 0.969 988, 969 988 0.969-988 0001 0.001 cutoff cut off 51180 511 80 >511.8 75 73 AUC (AUC 0804 804 0.804 0715 715 0.71 0892 892 0.892 factors Therefore populations ( P00 P<0. 544±4 5444 54 (544± 4844 484± p000 p=0.00 00 097 97 0.97 9 969988 0.969988 096998 0969 0.96 96 98 0.969-98 000 0.00 5118 51 8 >511. 7 080 0.80 071 71 0.7 089 89 0.89 P0 P<0 544± 5 (544 p00 p=0.0 09 0.9 96998 0.96998 09699 096 0.969-9 0.0 >511 08 0.8 07 0. P< (54 p0 p=0. 9699 0.9699 0.969- >51 (5 p=0 >5 p= >

Abstract Objective: Ascending thoracic aortic aneurysm (ATAA), seen in adults, is an important cause of morbidity and mortality. In this study, we aimed to evaluate the levels of mean platelet volume (MPV), mean platelet volume-to-platelet count ratio (MPVPCR), mean platelet volume-to-lymphocyte ratio (MPVLR), and red cell distribution width platelet count ratio (RDWPCR) in patients with thoracic aortic aneurysm. Methods: 105 patients admitted to the emergency department were diagnosed with thoracic aortic aneurysm between January and December 2014, and 100 healthy individuals were involved in this retrospective study. MPV, MPVLR, MPVPCR and RDWPCRs were calculated at the time of admission. Results: Platelet and lymphocyte levels were found to be significantly lower in the patient group when compared to the healthy group (P<0.001, P<0.001, respectively), while MPV, MPVPCR, MPVLR and RDWPCR were found to be significantly higher (P<0.001, P<0.001, P<0.001, and P=0.013, respectively). In the patient group, the high-sensitivity C-reactive protein was significantly higher (P<0.001), and the neutrophil (P=0.062) was also higher. In ROC analysis, MPVPCR had the highest sensitivity (80%) and RDWPCR had the highest specificity (72%). Conclusion: The results for MPV, MPVPCR, MPVLR and RDWPCR can be evaluated as useful parameters in the emergency clinical approach in the evaluation of inflammatory activity in ATAA patients. More extensive studies are required to address the role of these parameters in determining the severity of the disease.