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Abstract Olanzapine (OLZ) is an antipsychotic medication used to treat postpartum psychiatric symptoms. It aimed to evaluate the effects of administering OLZ to lactating rats on testicular parameters of adult Wistar rats. Mothers received 2.5, 5 or 10 mg/kg until weaning. Adult male rats showed decrease in body weight, weight of testes, epididymis, prostate, seminal gland and gonadosomatic index when higher doses of OLZ were administered. Testicular volumetric parameters, as well as the length of seminiferous tubules, were also reduced in animals treated with the highest doses of OLZ. The diameter of the seminiferous tubules and the height of the seminiferous epithelium were reduced. There was also a relevant decrease in the population of Sertoli cells and a relevant reduction in the volume of individual Leydig cells. Histopathological analysis of the testes showed lesions compatible with testicular degeneration in rats treated with the highest dose of OLZ. There was a significant reduction in plasma testosterone levels in all treatments. It is noted, therefore, that the adverse impact on the testes of the highest doses of the drug during the neonatal period persisted into adulthood, with the dose of 2.5 mg/kg of OLZ proving to be safer than the others. (OLZ symptoms 25 2 1 mgkg mg kg weaning epididymis prostate administered treatments noted therefore adulthood 2. others

https://doi.org/10.1590/0001-3765202420230561

Are salivary flow rates associated with histopathologic aspects in patients with rheumatoid arthritis?
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HELMS, Janaina Barbieri dos Santos

; BARBOSA, Carlos Augusto

; ABRAHÃO, Aline Corrêa

; CABRAL, Marcia Grillo

; BICA, Blanca Elena Rios Gomes

; TORRES, Sandra Regina

Brazilian Oral Research

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2022, Volume 36 elocation e0120

Resumo: En | Texto: En | PDF: En

Abstract The aim of this retrospective cross-sectional study was to verify the association between salivary flow rates (SFR) and the histopathologic aspects of labial salivary glands (LSG) in patients with rheumatoid arthritis (RA). Patients presenting rheumatologic diseases referred for oral evaluation were included in the study if they had RA and had SFR measured and LSG biopsy performed. Patients were excluded if they had systemic conditions that affect SFR or if they were being treated for hyposalivation. Cases without enough material for histopathologic analysis were also excluded. Data were collected through questionnaires, oral examination, resting and stimulated SFR, and LSG biopsies. A histopathologic reevaluation was carried out in order to seek for additional histopathologic aspects. Fifty-one patients met the inclusion criteria. The mean age was 53.5 years (25–77), and 94.1% were women. The median resting and stimulated SFRs were 0.24 mL/min and 1.02 mL/min, respectively. The presence of lymphocytic focus and fibrosis were significantly associated with stimulated SFR, but not with resting SFR. The odds ratio of patients who had hyposalivation for presenting a positive lymphocytic focus was 7.33 (confidence interval CI: 1.53–35.23) by the stimulated technique, and 2.56 (CI: 0.57–11.40) in resting SFR. In the medical records, 14 (31.80%) patients had been diagnosed with secondary Sjögren’s syndrome. In conclusion, stimulated SFR represent a good screening test to predict lymphocytic focus in LSG in patients with RA, which represents the most specific test to diagnose Sjögren’s syndrome.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0120

Diretrizes Brasileiras de Hipertensão Arterial – 2020
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Barroso, Weimar Kunz Sebba

; Rodrigues, Cibele Isaac Saad

; Bortolotto, Luiz Aparecido

; Mota-Gomes, Marco Antônio

; Brandão, Andréa Araujo

; Feitosa, Audes Diógenes de Magalhães

; Machado, Carlos Alberto

; Poli-de-Figueiredo, Carlos Eduardo

; Amodeo, Celso

; Mion Júnior, Décio

; Barbosa, Eduardo Costa Duarte

; Nobre, Fernando

; Guimarães, Isabel Cristina Britto

; Vilela-Martin, José Fernando

; Yugar-Toledo, Juan Carlos

; Magalhães, Maria Eliane Campos

; Neves, Mário Fritsch Toros

; Jardim, Paulo César Brandão Veiga

; Miranda, Roberto Dischinger

; Póvoa, Rui Manuel dos Santos

; Fuchs, Sandra C

; Alessi, Alexandre

; Lucena, Alexandre Jorge Gomes de

; Avezum, Alvaro

; Sousa, Ana Luiza Lima

; Pio-Abreu, Andrea

; Sposito, Andrei Carvalho

; Pierin, Angela Maria Geraldo

; Paiva, Annelise Machado Gomes de

; Spinelli, Antonio Carlos de Souza

; Nogueira, Armando da Rocha

; Dinamarco, Nelson

; Eibel, Bruna

; Forjaz, Cláudia Lúcia de Moraes

; Zanini, Claudia Regina de Oliveira

; Souza, Cristiane Bueno de

; Souza, Dilma do Socorro Moraes de

; Nilson, Eduardo Augusto Fernandes

; Costa, Elisa Franco de Assis

; Freitas, Elizabete Viana de

; Duarte, Elizabeth da Rosa

; Muxfeldt, Elizabeth Silaid

; Lima Júnior, Emilton

; Campana, Erika Maria Gonçalves

; Cesarino, Evandro José

; Marques, Fabiana

; Argenta, Fábio

; Consolim-Colombo, Fernanda Marciano

; Baptista, Fernanda Spadotto

; Almeida, Fernando Antonio de

; Borelli, Flávio Antonio de Oliveira

; Fuchs, Flávio Danni

; Plavnik, Frida Liane

; Salles, Gil Fernando

; Feitosa, Gilson Soares

; Silva, Giovanio Vieira da

; Guerra, Grazia Maria

; Moreno Júnior, Heitor

; Finimundi, Helius Carlos

; Back, Isabela de Carlos

; Oliveira Filho, João Bosco de

; Gemelli, João Roberto

; Mill, José Geraldo

; Ribeiro, José Marcio

; Lotaif, Leda A. Daud

; Costa, Lilian Soares da

; Magalhães, Lucélia Batista Neves Cunha

; Drager, Luciano Ferreira

; Martin, Luis Cuadrado

; Scala, Luiz César Nazário

; Almeida, Madson Q.

; Gowdak, Marcia Maria Godoy

; Klein, Marcia Regina Simas Torres

; Malachias, Marcus Vinícius Bolívar

; Kuschnir, Maria Cristina Caetano

; Pinheiro, Maria Eliete

; Borba, Mario Henrique Elesbão de

; Moreira Filho, Osni

; Passarelli Júnior, Oswaldo

; Coelho, Otavio Rizzi

; Vitorino, Priscila Valverde de Oliveira

; Ribeiro Junior, Renault Mattos

; Esporcatte, Roberto

; Franco, Roberto

; Pedrosa, Rodrigo

; Mulinari, Rogerio Andrade

; Paula, Rogério Baumgratz de

; Okawa, Rogério Toshiro Passos

; Rosa, Ronaldo Fernandes

; Amaral, Sandra Lia do

; Ferreira-Filho, Sebastião R.

; Kaiser, Sergio Emanuel

; Jardim, Thiago de Souza Veiga

; Guimarães, Vanildo

; Koch, Vera H.

; Oigman, Wille

; Nadruz, Wilson

Arquivos Brasileiros de Cardiologia

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Mar 2021, Volume 116 Nº 3 Páginas 516 - 658

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201238 10948 downloads

Necessidade de mudanças na educação médica e a percepção de professores antes da pandemia da Covid-19
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Serra, Sandra Torres

; Taquette, Stella Regina

; Bteshe, Mariana

; Corrêa, Letícia Moraes

; Mattos, Alice Vargas Vieira

Interface - Comunicação, Saúde, Educação

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2021, Volume 25 Supl. 1 elocation e200868

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Este estudo objetiva analisar questões da educação médica evidenciadas pelas medidas de distanciamento social provocadas pela pandemia do coronavírus19 associadas às percepções de professores de medicina sobre esses mesmos aspectos, em um momento prévio à eclosão da crise sanitária. Realizamos um recorte de resultados de uma pesquisa de natureza qualitativa e conduzimos a discussão com base na triangulação de dados entre observações de campo e entrevistas com professores. A pandemia reacendeu debates sobre a relevância de conteúdos, a utilização de tecnologias digitais para fins pedagógicos e o valor do trabalho colaborativo. Além disso, resgatou questões que envolvem habilidades de comunicação e a saúde de estudantes nas práticas do cuidado. Discutiremos a experiência passada articulando-a às experiências recentes e o que poderemos recolher para (re)construirmos os rumos da formação dos médicos.

This study aims to analyze medical education issues evidenced by the measures of social distancing due to the coronavirus pandemic19, associated with the perceptions of medical professors about these same aspects, in a moment prior to the outbreak of the health crisis. We focused in the results of a qualitative research and conducted a discussion based on the triangulation of data between field observations and interviews with professors. The pandemic has rekindled debates about the relevance of contents, the use of digital technologies for educational purposes and the value of collaborative work. Additionally, it provoked the emergence of issues involving communication skills and the health of students in care practices. We discuss past experiences articulating them with recent experiences and what we can collect to (re)build the direction of medical training.

El objetivo de este estudio es analizar cuestiones de la educación médica puestas en evidencia por las medidas de distancia social adoptadas por la pandemia del coronavirus 19, asociadas a las percepciones de profesores de medicina sobres esos mismos aspectos, en un momento previo a la eclosión de la crisis sanitaria. Realizamos un recorte de resultados de una investigación de naturaleza cualitativa y dirigimos la discusión a partir de la triangulación de datos entre observaciones de campo y entrevistas con profesores. La pandemia reencendió debates sobre la relevancia de contenidos, la utilización de tecnologías digitales para fines pedagógicos y el valor del trabajo colaborativo. Además, rescató cuestiones que envuelven habilidades de comunicación y la salud de estudiantes en las prácticas del cuidado. Discutiremos la experiencia pasada articulándola con las experiencias recientes y lo que podremos recoger para (re)construir los rumbos de formación de los médicos.

https://doi.org/10.1590/interface.200868

Necessidade de mudanças na educação médica e a percepção de professores antes da pandemia da Covid-19
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Serra, Sandra Torres

; Taquette, Stella Regina

; Bteshe, Mariana

; Corrêa, Letícia Moraes

; Mattos, Alice Vargas Vieira

Interface - Comunicação, Saúde, Educação

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2021, Volume 25 Supl. 1 elocation e200868

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/interface.200868 246 downloads

Neospora caninum infection in cattle in the state of Amazonas, Brazil: seroprevalence, spatial distribution and risk factors
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Azevedo Filho, Paulo Cesar Gonçalves de

; Ribeiro-Andrade, Müller

; Santos, Jomel Francisco dos

; Reis, Arthêmio Coelho dos

; Pinheiro Júnior, José Wilton

; Valença, Sandra Regina Fonseca de Araújo

; Samico-Fernandes, Erika Fernanda Torres

; Mota, Rinaldo Aparecido

Revista Brasileira de Parasitologia Veterinária

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2021, Volume 30 Nº 1 elocation e020820

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A pecuária na Amazônia tem crescido significativamente e, embora a neosporose em bovinos tenha sido relatada em todo o mundo, não há informações sobre N. caninum nos sistemas de produção no estado do Amazonas. Objetivou-se determinar a prevalência de anticorpos anti-Neospora caninum em bovinos, sua distribuição espacial e os fatores de risco associados à infecção por N. caninum no estado do Amazonas. Questionários foram aplicados aos fazendeiros, para avaliar fatores de risco associados à infecção por N. caninum. Amostras de sangue foram coletadas de 1.073 animais em 47 fazendas, em 33 municípios das quatro subpopulações amazonenses. Anticorpos IgG anti-N.caninum foram detectados pelo teste de imunofluorescência indireta, com prevalência geral de 30,2%, com soropositividade em 43 fazendas (91,5%), com prevalência variando de 2,2% a 69,2%. O maior número de pontos de alta densidade foi encontrado na subpopulação 3 (município de Apuí e demais municípios do rio Madeira e afluentes). Concluiu-se que N. caninum está presente com altos valores de soroprevalência, quando comparado a outros estados produtores de gado na região amazônica do Brasil. Os fatores identificados podem ser usados como indicadores de risco, para que medidas de controle possam ser implementadas para prevenir a infecção por N. caninum nesses rebanhos.

Abstract Livestock in the Amazon has grown significantly and, although neosporosis in cattle has been reported worldwide, there is no information about N. caninum in production systems in the state of Amazonas. The objective of this study was to determine the prevalence of anti-Neospora caninum antibodies in cattle, their spatial distribution and the risk factors associated with N. caninum infection in the state of Amazonas. Questionnaires were applied to farmers to assess risk factors associated with N. caninum infection. Blood samples were collected from 1,073 animals on 47 farms in 33 municipalities in the four Amazonian subpopulations. IgG anti-N.caninum antibodies were detected by the indirect fluorescence test, with a general prevalence of 30.2%, being seropositive in 43 farms (91.5%), with prevalence ranging from 2.2% to 69.2%. The highest number of high density points was found in subpopulation 3 (municipality of Apuí and other municipalities on the Madeira River and affluent). It was concluded that N. caninum is present with high seroprevalence values, when compared to other cattle producing states in the Amazon region of Brazil. The identified factors can be used as risk indicators so that control measures can be implemented to prevent infection by N. caninum in these herds.

https://doi.org/10.1590/s1984-296120201083 597 downloads

Oral health status of patients with multiple myeloma
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Feitosa, Édila Figuerêdo

; Magalhães, Roberto José Pessoa

; Barbosa, Carlos Augusto de Melo

; Guedes, Fabio Ribeiro

; Maiolino, Angelo

; Torres, Sandra Regina

Hematology, Transfusion and Cell Therapy

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Jun 2020, Volume 42 Nº 2 Páginas 166 - 172

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To describe the oral health status of patients with multiple myeloma and compare to a control group. Materials and methods: The medical history of the studied subjects was obtained from the medical records and through interviews. Trained examiners evaluated the oral mucosa, teeth, periodontium and imaging aspects. The dental status was evaluated by the decayed, missing and filled teeth index. The presence of bone lesions was investigated with cone beam computer tomography images of the jaws. Results: The most common oral mucosa features were paleness (31%) and coated tongue (14.3%) in the multiple myeloma group (N = 42); and coated (21.4%) and fissured tongue (10.7%) in the control group (N = 28). The mean DMFT index of patients with multiple myeloma was high, but not significantly different from controls (14.57 versus 19.69, p = 0.975). Hypodense lesions suggestive of multiple myeloma were observed in the jaws of 73.8% of the patients. Hypodense lesions related to teeth were detected in 33.3% of the patients and in 53.6% of the controls (p = 0.832). Conclusions: The studied population of multiple myeloma patients presented many oral health issues that needed attention. Thus, oral care should be included in the routine treatment to improve the quality of the oral status in these patients.

https://doi.org/10.1016/j.htct.2019.01.012 261 downloads

The frequency of oral conditions detected in hematology inpatients
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Gomes, Alessandra Oliveira Ferrari

; Silva Junior, Arley

; Noce, Cesar Werneck

; Ferreira, Marisa

; Maiolino, Angelo

; Torres, Sandra Regina

Hematology, Transfusion and Cell Therapy

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Set 2018, Volume 40 Nº 3 Páginas 240 - 244

Resumo: En | Texto: En | PDF: En

ABSTRACT Background: Oral manifestations may be the first signs of hematologic diseases, and may occur due to the disease itself or to treatment. Objective: To evaluate the frequency and types of oral conditions presented by patients on a hematology ward. Methods: Data were collected by oral examinations during weekly visits to a hematology ward. Six trained dentists performed the oral assessment based on the principles of oral semiology. All patients who accepted to be examined were included in the study. Patients who were unavailable or unable to have oral examinations were excluded. Data were recorded on protocol forms and in the electronic records of the institution. A descriptive analysis was performed. Results: Seventy-nine patients were included in the analysis; 50.6% were female and the mean age was 41.49 years. The most common reasons for hospitalization were chemotherapy and complications (81%), relapse (13.9%) and pre-transplant preparation (5%). The most frequent underlying diseases were multiple myeloma (17.7%), acute myeloid leukemia (15.4%) and acute lymphocytic leukemia (11.5%). Oral conditions were found in 36 (45.6%) patients, some of whom presented more than one condition. The most common oral conditions were dry lips (12.6%), mucositis (10.1%), petechiae (8.9%) and candidiasis (7.6%). Of the detected oral conditions, 56.9% were related to the underlying disease or chemotherapy and 20.2% were not related to the disease. Conclusion: This study shows the types and frequency of oral conditions observed in hematological inpatients. Awareness of these conditions is important for prevention and planning the care of patients with hematological diseases.

https://doi.org/10.1016/j.htct.2018.02.006 648 downloads

Can dentists detect multiple myeloma through oral manifestations?
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Almeida, Thaís Miranda Xavier de

; Cavalcanti, Édila Figuerêdo Feitosa

; Freitas, Alessandra da Silva

; Magalhães, Roberto José Pessoa de

; Maiolino, Angelo

; Torres, Sandra Regina

Hematology, Transfusion and Cell Therapy

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Mar 2018, Volume 40 Nº 1 Páginas 43 - 49

Resumo: En | Texto: En | PDF: En

Abstract Objective: To review published data on oral manifestations of multiple myeloma. Methods: An electronic database search was performed of articles published from 1971 to November 2016 in order to identify studies that reported oral manifestations of patients with multiple myeloma. Case reports and case series with oral manifestations of multiple myeloma in English were included in the study. An additional search was performed of the references of the selected articles. Results: Thirty-seven articles that reported 81 patients with oral manifestations of multiple myeloma were selected: 30 case reports (82%) and seven case series (18%). The most common clinical features in the dental cavity were swelling (65.4%), bone pain (33.3%), paresthesia (27.1%) and amyloidosis lesions (11.1%). Osteolytic lesions detected on imaging exams were reported in the majority of the patients (90.1%) as plasmacytomas or ‘punched-out’ lesions. Conclusions: Swelling and osteolytic lesions represent the most common clinical and radiographic signs of the jaws relating to multiple myeloma, respectively.

https://doi.org/10.1016/j.bjhh.2017.08.006 1196 downloads

10.

Brazilian guidelines for the diagnosis and treatment of cystic fibrosis
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Athanazio, Rodrigo Abensur

; Silva Filho, Luiz Vicente Ribeiro Ferreira da

; Vergara, Alberto Andrade

; Ribeiro, Antônio Fernando

; Riedi, Carlos Antônio

; Procianoy, Elenara da Fonseca Andrade

; Adde, Fabíola Villac

; Reis, Francisco José Caldeira

; Ribeiro, José Dirceu

; Torres, Lídia Alice

; Fuccio, Marcelo Bicalho de

; Epifanio, Matias

; Firmida, Mônica de Cássia

; Damaceno, Neiva

; Ludwig-Neto, Norberto

; Maróstica, Paulo José Cauduro

; Rached, Samia Zahi

; Melo, Suzana Fonseca de Oliveira

; Pinto, Leonardo Araújo

; Monte, Luciana Freitas Velloso

; Higa, Laurinda Yoko Shinzato

; Folescu, Tania Wrobel

; Marson, Fernando Augusto de Lima

; Sad, Isabela

; Servidoni, Maria de Fátima Correa Pimenta

; Kussek, Paulo

; Raskin, Salmo

; Zuana, Adriana Della

; Augustin, Albin

; Hoffmann, Anneliese

; Barbisan, Beatriz

; Hochhegger, Bruno

; Levy, Carlos Emilio

; Veiga, Claudine Sarmento da

; Ricachinevsky, Claudio

; Esposito, Concetta

; Escuissato, Dante

; Brandemburgo, Diego

; Marques, Elisabeth

; Aquino, Evanirso de

; Fischer, Gilberto Bueno

; Rodrigues, Joaquim Carlos

; Machado, Leticia

; Muramato, Lucia

; Costa, Lusmaia Damasceno Camargo

; Donadio, Marcio

; Castro, Marcos César Santos de

; Ribeiro, Maria Angela

; Santana, Maria Angélica

; Canan, Mariane

; Almeida, Marina Buarque de

; Britto, Murilo

; Dalcin, Paulo Roth Tarso

; Ramos, Regina Terse Trindade

; Chiba, Sonia

; Martins, Valéria de Carvalho

; Lacerda, Claudine

; Barbosa, Eliana

; Guimarães, Elizabet Vilar

; Hessel, Gabriel

; Gurmini, Jocemara

; Neri, Lenycia

; Nogueira, Marcelo Coelho

; Wayhs, Mônica Chang

; Simon, Miriam Isabel Santos

; Fernandes, Arlene Gonçalves dos Santos

; Silva, Claudia de Castro de

; Albuquerque, Cristiano Túlio Maciel

; Souza, Edna Lúcia

; Silva, Fernando Antonio de Abreu e

; Dalcin, Paulo de Tarso

; Noronha, Renata Maria de

; Teixeira, Ricardo

; Machado, Sandra Helena

; Camargo, Spencer Marcantonio

; Rozov, Tatiana

; Rodrigues, Ticiana da Costa

Jornal Brasileiro de Pneumologia

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Jun 2017, Volume 43 Nº 3 Páginas 219 - 245

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A fibrose cística (FC) é uma doença genética autossômica recessiva caracterizada pela disfunção do gene CFTR. Trata-se de uma doença multissistêmica que ocorre mais frequentemente em populações descendentes de caucasianos. Nas últimas décadas, diversos avanços no diagnóstico e tratamento da FC mudaram drasticamente o cenário dessa doença, com aumento expressivo da sobrevida e qualidade de vida. Atualmente, o Brasil dispõe de um programa de ampla cobertura para a triagem neonatal de FC e centros de referência distribuídos na maior parte desses estados para seguimento dos indivíduos. Antigamente confinada à faixa etária pediátrica, tem-se observado um aumento de pacientes adultos com FC tanto pelo maior número de diagnósticos de formas atípicas, de expressão fenotípica mais leve, assim como pelo aumento da expectativa de vida com os novos tratamentos. Entretanto, ainda se observa uma grande heterogeneidade no acesso aos métodos diagnósticos e terapêuticos para FC entre as diferentes regiões brasileiras. O objetivo dessas diretrizes foi reunir as principais evidências científicas que norteiam o manejo desses pacientes. Um grupo de 18 especialistas em FC elaborou 82 perguntas clínicas relevantes que foram divididas em cinco categorias: características de um centro de referência; diagnóstico; tratamento da doença respiratória; tratamento gastrointestinal e nutricional; e outros aspectos. Diversos profissionais brasileiros atuantes na área da FC foram convidados a responder as perguntas formuladas pelos coordenadores. A literatura disponível foi pesquisada na base de dados PubMed com palavras-chave, buscando-se as melhores respostas às perguntas dos autores.

ABSTRACT Cystic fibrosis (CF) is an autosomal recessive genetic disorder characterized by dysfunction of the CFTR gene. It is a multisystem disease that most often affects White individuals. In recent decades, various advances in the diagnosis and treatment of CF have drastically changed the scenario, resulting in a significant increase in survival and quality of life. In Brazil, the current neonatal screening program for CF has broad coverage, and most of the Brazilian states have referral centers for the follow-up of individuals with the disease. Previously, CF was limited to the pediatric age group. However, an increase in the number of adult CF patients has been observed, because of the greater number of individuals being diagnosed with atypical forms (with milder phenotypic expression) and because of the increase in life expectancy provided by the new treatments. However, there is still great heterogeneity among the different regions of Brazil in terms of the access of CF patients to diagnostic and therapeutic methods. The objective of these guidelines was to aggregate the main scientific evidence to guide the management of these patients. A group of 18 CF specialists devised 82 relevant clinical questions, divided into five categories: characteristics of a referral center; diagnosis; treatment of respiratory disease; gastrointestinal and nutritional treatment; and other aspects. Various professionals working in the area of CF in Brazil were invited to answer the questions devised by the coordinators. We used the PubMed database to search the available literature based on keywords, in order to find the best answers to these questions.

https://doi.org/10.1590/s1806-37562017000000065 75529 downloads

11.

Possible links between osteoporosis and periodontal disease
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Penoni, Daniela Cia

; Leão, Anna Thereza Thomé

; Fernandes, Tatiana Melo

; Torres, Sandra Regina

Revista Brasileira de Reumatologia

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Mai 2017, Volume 57 Nº 3 Páginas 270 - 273

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1016/j.rbre.2016.03.004 5593 downloads

12.

Genetic divergence between genotypes for male and female broilers
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Veloso, Rogério de Carvalho

; Ferreira, Talita Andrade

; Winkelstroter, Larissa Kretli

; Silva, Maria Teresa Polcaro

; Pires, Aldrin Vieira

; Torres Filho, Rodolpho de Almeida

; Pinheiro, Sandra Regina Freitas

Ciência Rural

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Mar 2016, Volume 46 Nº 3 Páginas 554 - 559

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: Objetivou-se com este estudo verificar a divergência genética entre três genótipos de frangos de corte, de ambos os sexos, utilizando o desempenho e as características de carcaça por meio da análise multivariada. Utilizaram-se 990 pintos de um dia, sexados, dos seguintes grupos genéticos: Cobb 500, Hubbard Flex, e Ross 308. Avaliaram-se as seguintes variáveis: ganho em peso médio diário, consumo de ração médio diário, conversão alimentar, peso corporal, peso e rendimento do peito e da carcaça, nos períodos: 1 a 35 dias e 1 a 42 dias de idade. O desempenho dos grupos genéticos foi avaliado por meio da Análise de Variância Multivariada e da função discriminante linear de Fisher, usando os testes do maior autovalor de Roy e da união-interseção de Roy para as comparações múltiplas. O estudo da divergência genética foi feito por meio da análise por variáveis canônicas e pelo método de otimização de Tocher. As fêmeas dos grupos genéticos Cobb 500, Hubbard Flex e Ross 308 apresentaram médias canônicas diferentes dos machos desses mesmos genótipos. As duas primeiras variáveis canônicas explicaram 88,10% da variação entre os grupos genéticos. A divergência genética entre os grupos genéticos avaliados permitiu a formação de dois grupos com os seguintes genótipos: grupo 1 - Fêmeas Cobb 500, Hubbard Flex e Ross 308; e grupo 2 - Machos Cobb 500, Hubbard Flex e Ross 308.

ABSTRACT: The aim of this study was to verify the genetic divergence amongst three broiler genotype, from both sexes, by means of a multivariate performance analysis and carcass traits. Nine hundred and ninety sexed, one-day chicks were utilized; belonged to the following genetic groups: Cobb 500, Hubbard Flex, and Ross 308. The study evaluated the daily average weight gain, the daily average ration consumption, feed conversion, body weight, weight and performance for breast, and carcass over the period from 1 to 35, and from 1 to 42 days of age. Performance of the genetic groups was evaluated by means of multivariate analysis of variance and by Fisher's linear discriminant function, using Roy's largest eigenvalue and Roy's union-intersection test for multiple comparisons. The genetic divergence study was carried out through the analysis of canonical variables and through Tocher method. Female animals from Cobb 500, Hubbard Flex, and Ross 308 genetic groups presented different canonical averages from males of the same groups. First two canonical variables explained 88.10% of variation between genetic groups. Genetic divergence between the evaluated groups allowed formation of two clusters with the following genotypes: Cluster 1 - Cobb 500, Hubbard Flex and Ross 308 females; Cluster 2 - Cobb 500, Hubbard Flex and Ross 308 males.

https://doi.org/10.1590/0103-8478cr20141466 1285 downloads

13.

Detection of human papillomavirus in dental biofilm and the uterine cervix of a pregnant adolescent
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Cavalcanti, Édila Figuerêdo Feitosa

; Silva, Célia Regina

; Ferreira, Dennis Carvalho

; Ferreira, Mariana Vasconcellos Martins

; Vanderborght, Patrícia Rosa

; Torres, Maria Cynésia Medeiros Barros

; Torres, Sandra Regina

Sao Paulo Medical Journal

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Fev 2016, Volume 134 Nº 1 Páginas 88 - 91

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

CONTEXTO: A adolescência e a gestação são consideradas fatores de risco para a infecção pelo papilomavírus humano (HPV). A relação entre essa infecção no colo do útero e na boca num mesmo paciente é controversa. RELATO DE CASO: Descrever o caso de uma adolescente grávida de 16 anos que apresentou a infecção pelo HPV no colo do útero e na boca. Esfregaços foram realizados no colo do útero e em língua/palato. Amostras de biofilme dental também foram coletadas. Para detectar o HPV, foi utilizada a técnica do microarranjo. O HPV 56 foi o subtipo encontrado no esfregaço cervical e o tipo HPV 6 no biofilme dental. CONCLUSÕES: Observamos, nessa adolescente grávida, a presença do HPV na boca e no colo do útero, mas os subtipos virais que infectavam essas duas regiões eram distintos.

CONTEXT: Adolescence and pregnancy are considered to be risk factors for human papillomavirus (HPV) infection. The relationship between this infection in the uterine cervix and oral HPV infection is controversial. CASE REPORT: This report describes a case of a pregnant 16-year-old adolescent who presented HPV infection in the uterine cervix and the mouth. Smears were collected from the cervix and the tongue/palate. Dental biofilm samples were also collected. The microarray technique was used to detect HPV. The HPV 56 subtype was observed in the cervical smear and HPV 6 in dental biofilm. CONCLUSION: In this pregnant adolescent, HPV infection was present in both the cervix and the mouth, but the HPV subtypes infecting these two areas were different.

https://doi.org/10.1590/1516-3180.2014.8812810 1817 downloads

14.

Drugs or disease: evaluating salivary function in RA patients
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TORRES, Sandra Regina

; PEDRAZAS, Carlos Henrique Silva

; CORREIA, Marcos Paulo Veloso

; AZEVEDO, Mario Newton Leitão de

; ZAMPROGNO, Thaís

; SILVA JUNIOR, Arley

; GONÇALVES, Lucio Souza

; PAPI, José Angelo de Souza

Brazilian Oral Research

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2016, Volume 30 Nº 1 elocation e106

Resumo: En | Texto: En | PDF: En

Abstract Oral complications of RA may include temporomandibular joint disorders, mucosa alterations and symptoms of dry mouth. The aim of this study was to evaluate the salivary gland function of subjects with rheumatoid arthritis (RA) comparing it to healthy controls. Subjects with other systemic conditions known to affect salivary functions were excluded. A questionnaire was applied for the evaluation of xerostomia. Resting and chewing-stimulated salivary flow rates (SFR) were obtained under standard conditions. There were 145 subjects included of the study (104 RA and 38 controls). About 66.7% of the RA subjects and 2.4% in control group presented xerostomia. The median resting SFR were 0.24 ml/min for RA subjects and 0.40 mL/min for controls (p = 0.04). The median stimulated SFR were 1.31 mL/min for RA subjects and 1.52 ml/min for controls (p = 0.33). No significant differences were found between resting and stimulated SFR of RA subjects not using xerogenic medications and controls. There was significantly higher number of subjects presenting hyposalivation in the RA group than among controls, even when subjects using xerogenic medications were eliminated from the analysis. In conclusion, hyposalivation and xerostomia were more frequent among RA subjects not using xerogenic medication than among controls, although there were no significant differences in the median SFR between groups.

https://doi.org/10.1590/1807-3107BOR-2016.vol30.0106 1600 downloads

15.

ERICA: prevalence of metabolic syndrome in Brazilian adolescents
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Kuschnir, Maria Cristina C

; Bloch, Katia Vergetti

; Szklo, Moyses

; Klein, Carlos Henrique

; Barufaldi, Laura Augusta

; Abreu, Gabriela de Azevedo

; Schaan, Beatriz

; Veiga, Gloria Valeria da

; Silva, Thiago Luiz Nogueira da

; Vasconcellos, Maurício T L de

; Moraes, Ana Júlia Pantoja de

; Oliveira, Ana Mayra Andrade de

; Tavares, Bruno Mendes

; Oliveira, Cecília Lacroix de

; Cunha, Cristiane de Freitas

; Giannini, Denise Tavares

; Belfort, Dilson Rodrigues

; Santos, Eduardo Lima

; Leon, Elisa Brosina de

; Oliveira, Elizabete Regina Araújo

; Fujimori, Elizabeth

; Borges, Ana Luíza

; Magliano, Erika da Silva

; Vasconcelos, Francisco de Assis Guedes

; Azevedo, George Dantas

; Brunken, Gisela Soares

; Guimarães, Isabel Cristina Britto

; Faria Neto, José Rocha

; Oliveira, Juliana Souza

; Carvalho, Kenia Mara B de

; Gonçalves, Luis Gonzaga de Oliveira

; Monteiro, Maria Inês

; Santos, Marize M

; Muniz, Pascoal Torres

; Jardim, Paulo César B Veiga

; Ferreira, Pedro Antônio Muniz

; Montenegro Jr, Renan Magalhães

; Gurgel, Ricardo Queiroz

; Vianna, Rodrigo Pinheiro

; Vasconcelos, Sandra Mary

; Martins, Stella Maris Seixas

; Goldberg, Tamara Beres Lederer

Revista de Saúde Pública

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2016, Volume 50 Supl. 1 elocation 11s

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Determinar a prevalência de síndrome metabólica e de seus componentes em adolescentes brasileiros. MÉTODOS Foram avaliados 37.504 adolescentes, participantes do Estudo de Riscos Cardiovasculares em Adolescentes (ERICA), estudo transversal de âmbito nacional e de base escolar. Os adolescentes, de 12 a 17 anos de idade, residiam em municípios com mais de 100 mil habitantes. A amostra foi estratificada e conglomerada em escolas e turmas. Os critérios da International Diabetes Federation foram utilizados para definir síndrome metabólica. Prevalências de síndrome metabólica foram estimadas segundo sexo, faixa etária, tipo de escola e estado nutricional. RESULTADOS Dos 37.504 adolescentes, 50,2% eram do sexo feminino; 54,3% tinham de 15 a 17 anos e 73,3% estudavam em escolas públicas. A prevalência nacional de síndrome metabólica foi 2,6% (IC95% 2,3-2,9), discretamente maior no sexo masculino e naqueles de 15 a 17 anos na maioria das macrorregiões. A prevalência foi a maior nos residentes na macrorregião Sul, nas adolescentes mais jovens e nos adolescentes mais velhos. A prevalência foi maior nas escolas públicas (2,8% [IC95% 2,4-3,2]) que nas escolas privadas (1,9% [IC95% 1,4-2,4]) e nos adolescentes obesos em comparação aos não obesos. As combinações de componentes mais frequentes, respondendo por 3/4 das combinações, foram: circunferência de cintura elevada, HDL-colesterol baixo e pressão arterial elevada, seguida de circunferência da cintura elevada, lipoproteína de alta densidade (HDL-c) baixo e triglicerídeos elevados, e wpor circunferência da cintura elevada, HDL baixa e triacilgliceróis e pressão arterial elevados. A HDL baixa foi o segundo componente mais frequente, mas a maior prevalência de síndrome metabólica (26,8%) foi observada na presença de triglicerídeos elevado. CONCLUSÕES O ERICA é o primeiro estudo nacional a apresentar prevalências de síndrome metabólica e descrever a participação dos seus componentes. Apesar de a prevalência da síndrome metabólica ter sido baixa, as altas prevalências de alguns componentes e de participação de outros na composição da síndrome torna importante o diagnóstico precoce de tais alterações, mesmo que não agrupadas na síndrome metabólica.

ABSTRACT OBJECTIVE To determine the prevalence of metabolic syndrome and its components in Brazilian adolescents. METHODS We evaluated 37,504 adolescents who were participants in the Study of Cardiovascular Risks in Adolescents (ERICA), a cross-sectional, school-based, national study. The adolescents, aged from 12 to 17 years, lived in cities with populations greater than 100,000 inhabitants. The sample was stratified and clustered into schools and classes. The criteria set out by the International Diabetes Federation were used to define metabolic syndrome. Prevalences of metabolic syndrome were estimated according to sex, age group, school type and nutritional status. RESULTS Of the 37,504 adolescents who were evaluated: 50.2% were female; 54.3% were aged from 15 to 17 years, and 73.3% were from public schools. The prevalence of metabolic syndrome was 2.6% (95%CI 2.3-2.9), slightly higher in males and in those aged from 15 to 17 years in most macro-regions. The prevalence was the highest in residents from the South macro-region, in the younger female adolescents and in the older male adolescents. The prevalence was higher in public schools (2.8% [95%CI 2.4-3.2]), when compared with private schools (1.9% [95%CI 1.4-2.4]) and higher in obese adolescents when compared with nonobese ones. The most common combinations of components, referring to 3/4 of combinations, were: enlarged waist circumference (WC), low HDL-cholesterol (HDL-c) and high blood pressure; followed by enlarged WC, low HDL-c and high triglycerides; and enlarged WC, low HDL-c, high triglycerides and blood pressure. Low HDL was the second most frequent component, but the highest prevalence of metabolic syndrome (26.8%) was observed in the presence of high triglycerides. CONCLUSIONS ERICA is the first Brazilian nation-wide study to present the prevalence of metabolic syndrome and describe the role of its components. Despite the prevalence of Metabolic Syndrome being low, the high prevalences of some components and participation of others in the syndrome composition shows the importance of early diagnosis of this changes, even if not grouped within the metabolic syndrome.

https://doi.org/10.1590/s01518-8787.2016050006701 1789 downloads

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