Compared to other species, components of Combretum lanceolatum are still with few data reported in the literature. This work describes the compounds identification, antioxidant and antimicrobial activities of C. lanceolatum twigs. Ethanolic extract (EECLT) from C. lanceolatum twigs was submitted to partition obtaining: hexane (HF), diethyl ether (EEF), ethyl acetate (EAF) and hydromethanolic (HMF) fractions. They were analyzed by gas chromatography-mass spectrometry, high performance liquid chromatography coupled to mass spectrometry and direct insertion mass spectrometry and evaluated for antioxidant assay (2,2-diphenyl-1-picrylhydrazyl (DPPH) method) and antimicrobial assay. Fifty-seven compounds were identified in the fractions. In antioxidant assay, EECLT and EAF demonstrated good antioxidant potential (half maximal effective concentration (EC50): 57.9 and 45.4 µg mL–1, respectively), better than the positive control butylated hydroxytoluene (BHT) (EC50: 69.34 µg mL–1). For antimicrobial assay, all fractions presented promising minimal inhibitory concentration (MIC). EECLT presented the best values against Staphylococcus aureus (125 µg mL–1) and Escherichia coli (62.5 µg mL–1) and better than the positive control fluconazole (8 and 16 µg mL–1) against Candida albicans (3.9 µg mL–1) and Candida krusei (15.6 µg mL–1) strains. This study presents relevant chemical and biological information about C. lanceloatum expanding the knowledge of Brazilian flora. species literature identification C (EECLT obtaining HF, HF , (HF) EEF, EEF (EEF) (EAF HMF (HMF chromatographymass 2,2diphenyl1picrylhydrazyl 22diphenyl1picrylhydrazyl diphenylpicrylhydrazyl 2,2 diphenyl 1 picrylhydrazyl 2 DPPH (DPPH method Fiftyseven Fifty seven half EC50 EC (EC50) 579 57 9 57. 454 45 4 45. mL1 mL mL–1 respectively, respectively respectively) BHT (BHT (EC50 6934 69 34 69.3 mL–1. . MIC. MIC (MIC) 125 (12 62.5 625 62 5 (62. 8 ( 3.9 39 3 (3. 15.6 156 15 6 (15. strains flora (HF (EEF 2diphenyl1picrylhydrazyl 22 2, EC5 mL– (EC5 693 69. (MIC 12 (1 62. (62 3. (3 15. (15 (EC (6

ABSTRACT Background: Microscopic colitis (MC) is a chronic inflammatory bowel disease causing non-bloody diarrhea, and several cases are undiagnosed as a hidden cause of chronic diarrhea. Objective: We aimed to report the symptoms, delay diagnosis and the treatment of MC in a case series. Methods: All patients were treated at a Gastroenterology reference office from May 2022 to June 2023. Personal history including preexisting disorders, use of medications and smoking habits were collected. The delay between the onset of symptoms and the correct diagnosis was informed. All patients consented to use budesonide MMX (Corament®) off label. Results: During the study period, six Caucasoid patients were diagnosed with MC, five females and one male, between the ages of 65 and 74. All patients had comorbities and were taking multiple prescription drugs. Laboratory findings showed negative serology for celiac disease for all patients, normal levels of albumin and vitamin B12. The delay between the symptoms and the MC diagnosis varied from 2 months to 6 years. All patients had a previous diagnosis of irritable bowel syndrome. All patients were in complete clinical remission during the treatment and referred no side effects of the drug. Conclusion: Older females using high-risk medications are suggestive of MC. Preventing delay in the diagnosis of MC is crucial to improvement in patients´ quality of life. Budesonide MMX appears to be effective, safe and well-tolerated. Background (MC nonbloody non bloody diarrhea Objective series Methods 202 2023 disorders collected informed Corament® Corament (Corament® label Results period male 74 drugs B12 B years syndrome drug Conclusion highrisk high risk life effective welltolerated. welltolerated well tolerated. tolerated well-tolerated 20 (Corament 7 B1

RESUMO Contexto: A colite microscópica (CM) é uma doença inflamatória intestinal crônica que causa diarreia não sanguinolenta, e vários casos não são diagnosticados como uma causa oculta de diarreia crônica. Objetivo: Esse estudo visou relatar os sintomas, qual o atraso diagnóstico e o tratamento da CM em uma série de casos. Métodos: Todos os pacientes foram atendidos em um consultório de referência em Gastroenterologia no período de maio de 2022 a junho de 2023. Foram coletados antecedentes pessoais, incluindo distúrbios preexistentes, uso de medicamentos e tabagismo. Foi buscado o período entre o início dos sintomas e o diagnóstico correto. Todos os pacientes consentiram em usar budesonida MMX (Corament®) off label. Resultados: Durante o período do estudo, seis pacientes caucasóides foram diagnosticados com CM, cinco mulheres e um homem, com idades entre 65 e 74 anos. Todos os pacientes apresentavam comorbidades e faziam uso de vários medicamentos prescritos. Os achados laboratoriais mostraram sorologia negativa para doença celíaca em todos os pacientes, níveis normais de albumina e vitamina B12. O atraso entre os sintomas e o diagnóstico de CM variou de 2 meses a 6 anos. Todos os pacientes tinham diagnóstico prévio de síndrome do intestino irritável. Todos os pacientes apresentaram remissão clínica completa durante o tratamento e não referiram efeitos colaterais da droga. Conclusão: As mulheres mais velhas que usam medicamentos de alto risco são sugestivas de CM. Evitar o atraso no diagnóstico de CM é fundamental para melhorar a qualidade de vida dos pacientes. A budesonida MMX foi eficaz, segura e bem tolerada. Contexto (CM sanguinolenta Objetivo Métodos 202 2023 pessoais preexistentes tabagismo correto Corament® Corament (Corament® label Resultados homem 7 anos prescritos B12 B irritável droga Conclusão eficaz tolerada 20 (Corament B1

Abstract High expression of MMP-2 and MMP-9 in periapical lesions plays an important role in the degradation of the extracellular matrix. This study aimed to investigate the effect of epigallocatechin-3-gallate (EGCG)-based endodontic paste as an intracanal dressing on the expression of MMP-2 and MMP-9 in periapical lesions. Periapical lesions were experimentally induced in 35 mature beagle dog premolars randomly divided into healthy teeth, untreated periapical lesions, periapical lesions treated in a single session (control groups), and periapical lesions treated in two sessions with EGCG or calcium hydroxide-based pastes (experimental groups). After 120 days, specimens were obtained for histopathologic and immunofluorescence analyses to assess the expression of MMP-2 and MMP-9. The statistical analysis was performed using a p-value of 0.05. Endodontic treatment in two sessions using medication with EGCG and calcium hydroxide-based pastes provided similar repair of the apical and periapical tissues and neoformation of periodontal ligament fibers, cementum, and alveolar bone (p>0.05). The experimental groups treated in two sessions with both medications presented expression of MMP-2 and MMP-9 similar to that in healthy teeth (p>0.05), and significantly lower than teeth treated in a single session or untreated periapical lesions (p <0.001). Expression of MMP-2 and MMP-9 was observed in the cytoplasm of fibroblasts, osteoblasts, cementoblasts, cementocytes, and vascular endothelium. The use of EGCG-based endodontic paste reduced the expression of MMP-2 and MMP-9 and allowed repair of periapical lesions, similar to calcium hydroxide-based paste, and superior to treatment performed in a single session. MMP2 MMP 2 MMP- MMP9 9 matrix epigallocatechin3gallate epigallocatechingallate epigallocatechin 3 gallate EGCGbased based control groups, , groups) hydroxidebased hydroxide groups. . 12 days MMP9. 9. pvalue p value 005 0 05 0.05 fibers cementum p>0.05. p005 p>0.05 (p>0.05) p>0.05, <0.001. 0001 <0.001 001 <0.001) fibroblasts osteoblasts cementoblasts cementocytes endothelium 1 00 0.0 p00 p>0.0 (p>0.05 000 <0.00 0. p0 p>0. (p>0.0 <0.0 p>0 (p>0. <0. p> (p>0 <0 (p> <

Resumo A alta expressão de MMP-2 e MMP-9 em lesões periapicais desempenha um papel importante na degradação da matriz extracelular. Este estudo teve como objetivo investigar o efeito de uma pasta à base de epigalocatequina-3-galato (EGCG) como curativo intracanal na expressão de MMP-2 e MMP-9 em lesões periapicais. Lesões periapicais foram induzidas experimentalmente em 35 pré-molares de cães da raça beagle, maduros, divididos aleatoriamente em dentes saudáveis, lesões periapicais não tratadas, lesões periapicais tratadas em uma única sessão e lesões periapicais tratadas em duas sessões com a pasta de EGCG ou pasta à base de hidróxido de cálcio. O operador monitorou os animais e realizou a eutanásia após 120 dias para análises histopatológicas e de imunofluorescência para avaliar a expressão de MMP-2 e MMP-9. A análise estatística foi realizada utilizando p=0,05. O tratamento endodôntico em duas sessões com pasta à base de EGCG e pasta à base de hidróxido de cálcio proporcionou níveis semelhantes de reparação dos tecidos apicais e periapicais e neoformação de fibras do ligamento periodontal, cemento e osso alveolar. Em ambos os grupos, a expressão de MMP-2 e MMP-9 foi mínima, sendo observada no citoplasma de fibroblastos, osteoblastos, cementoblastos, cementócitos e endotélio vascular. Em ambos os grupos tratados em duas sessões, a expressão de MMP-2 e MMP-9 foi semelhante à dos dentes hígidos e significativamente menor do que nas lesões periapicais tratadas em sessão única ou não tratadas (p < 0,001). O uso da pasta à base de EGCG reduziu a expressão de MMP-2 e MMP-9 e permitiu o reparo de lesões periapicais, semelhante à pasta à base de hidróxido de cálcio, e foi superior ao tratamento realizado em sessão única. MMP2 MMP 2 MMP- MMP9 9 extracelular epigalocatequina3galato epigalocatequinagalato epigalocatequina 3 galato (EGCG prémolares pré molares beagle maduros saudáveis 12 MMP9. 9. p005 p 0 05 p=0,05 periodontal alveolar mínima fibroblastos osteoblastos cementoblastos vascular 0,001. 0001 0,001 . 001 0,001) 1 p00 p=0,0 000 0,00 00 p0 p=0, 0,0 p=0 0, p=

Abstract Brachycephalic breeds of dogs, most of which show signs of the brachycephalic syndrome may have greater parasympathetic stimulation than other breeds, leading to higher values of heart rate variability and vagal tone index. The aim of this study was to establish a computerized electrocardiographic study and an assessment of the vagus sympathetic balance through heart rate variability and vagal tone index of five brachycephalic breeds compared to mesocephalic dogs. Sixty dogs were used, divided into groups made up of Boxers, English Bulldogs, French Bulldogs, Pugs, Shih-Tzu and no defined breed mesocephalic dogs. Statistical analysis was carried out using the Shapiro-Wilk test, Kruskal-Wallis and Dunn’s test or ANOVA and Bonferroni (p<0.05). In the evaluation of vagal sympathetic balance among all the dogs, there was a negative correlation between heart rate and HRV 10RR (r = - 0.7678; p < 0.0001), HRV 20RR (r = - 0.8548, p < 0.0001) and VVTI (r = - 0.2770; p = 0.0321). It can therefore be concluded that the dog’s breed and morphology did not alter its electrocardiographic parameters or heart rate variability. The vagal tone index, which in other studies differed in brachycephalic dogs, showed no difference when compared separately in brachycephalic breeds. used Boxers Bulldogs Pugs ShihTzu Shih Tzu ShapiroWilk Shapiro Wilk KruskalWallis Kruskal Wallis Dunns Dunn s p<0.05. p005 p<0.05 . 0 05 (p<0.05) RR r 0.7678 07678 7678 0.0001, 00001 0.0001 , 0001 08548 8548 0.8548 0.2770 02770 2770 0.0321. 00321 0.0321 0321 0.0321) dog p00 p<0.0 (p<0.05 0.767 0767 767 0000 0.000 000 0854 854 0.854 0.277 0277 277 0032 0.032 032 p0 p<0. (p<0.0 0.76 076 76 0.00 00 085 85 0.85 0.27 027 27 003 0.03 03 p<0 (p<0. 0.7 07 7 0.0 08 8 0.8 0.2 02 2 p< (p<0 0. (p< (p

Background: Adhering to a diet adequate in macronutrients is crucial for the secondary prevention of cardiovascular diseases. Objective: To assess the prevalence of adherence to recommendations for the consumption of dietary fatty acids for the prevention and treatment of cardiovascular diseases and to estimate whether the presence of certain cardiovascular risk factors would be associated with adherence. Methods: Cross-sectional study using baseline data from 2,358 participants included in the "Brazilian Cardioprotective Nutritional Program Trial". Dietary intake and cardiovascular risk factors were assessed. Adequate intake of polyunsaturated fatty acids (PUFA) was considered as ≥10% of total daily energy intake; for monounsaturated fatty acids (MUFA), 20%; and for saturated fatty acids (SFA), <7% according to the Brazilian Society of Cardiology. A significance level of 5% was considered in the statistical analysis. Results: No participant adhered to all recommendations simultaneously, and more than half (1,482 [62.9%]) did not adhere to any recommendation. Adherence exclusively to the SFA recommendation was the most prevalent, fulfilled by 659 (28%) participants, followed by adherence exclusively to the PUFA (178 [7.6%]) and MUFA (5 [0.2%]) recommendations. There was no association between the number of comorbidities and adherence to nutritional recommendations (p = 0.269). Participants from the Brazilian Northeast region showed a higher proportion of adherence to SFA consumption recommendations (38.42%) and lower adherence to PUFA intake (3.52%) (p <0.001) compared to other regions. Conclusions: Among the evaluated sample, there was low adherence to nutritional recommendations for dietary fatty acid consumption. Background Objective Methods Crosssectional Cross sectional 2358 2 358 2,35 Trial. Trial . Trial" assessed (PUFA 10 ≥10 MUFA, , (MUFA) 20% 20 SFA, (SFA) 7 <7 Cardiology 5 analysis Results simultaneously 1,482 1482 1 482 (1,48 62.9% 629 62 9 [62.9%] prevalent 65 28% 28 (28% 178 (17 7.6% 76 6 [7.6%] ( 0.2% 02 0 [0.2%] p 0.269. 0269 0.269 269 0.269) 38.42% 3842 38 42 (38.42% 3.52% 352 3 52 (3.52% <0.001 0001 001 regions Conclusions sample 235 35 2,3 ≥1 (MUFA (SFA < 1,48 148 48 (1,4 62.9 [62.9% (28 17 (1 7.6 [7.6% 0.2 [0.2% 026 0.26 26 38.42 384 4 (38.42 3.52 (3.52 <0.00 000 00 23 2, ≥ 1,4 14 (1, 62. [62.9 (2 7. [7.6 0. [0.2 38.4 (38.4 3.5 (3.5 <0.0 1, [62. [7. [0. 38. (38. 3. (3. <0. [62 [7 [0 (38 (3 <0 [6 [

Resumo Fundamento: A adesão à uma alimentação adequada em macronutrientes é fundamental para a prevenção secundária de doenças cardiovasculares. Objetivo: Avaliar a prevalência de adesão às recomendações de consumo de ácidos graxos para prevenção e tratamento de doenças cardiovasculares, e estimar se a presença de determinados fatores de risco cardiovascular estaria associada à adesão. Métodos: Estudo transversal com os dados de linha de base de 2358 participantes do estudo "Brazilian Cardioprotective Nutritional Program Trial". Dados de consumo alimentar, e fatores de risco cardiovascular foram avaliados. Foi considerada, de acordo com a Sociedade Brasileira de Cardiologia, uma ingestão adequada de ácidos graxos poli-insaturados (AGPI) ≥10% do consumo total de energia diária, para ácidos graxos monoinsaturados (AGM), 20% e para ácidos graxos saturados (AGS), <7%. Na análise estatística foi considerando nível de significância de 5%. Resultados: Nenhum participante aderiu a todas as recomendações de forma simultânea e mais da metade (1482 [62,9%]) não aderiu a nenhuma recomendação. A adesão exclusivamente à recomendação de AGS foi a mais prevalente, sendo cumprida por 659 (28%) dos participantes, seguida da adesão exclusivamente à recomendação de AGP (178 [7,6%]) e de AGM (5 [0,2%]). Não houve associação entre o número de comorbidades e a adesão às recomendações nutricionais (p =0,269). Os participantes da região Nordeste do país apresentaram maior proporção de adesão às recomendações para consumo de AGS (38,42%), e menor para ingestão de AGPI (3,52%) (p <0,001) em comparação às demais. Conclusões: Na amostra avaliada, evidenciou-se baixa adesão às recomendações nutricionais para consumo de ácidos graxos. Fundamento cardiovasculares Objetivo Métodos 235 Brazilian Trial. Trial . Trial" alimentar avaliados considerada Cardiologia poliinsaturados poli insaturados (AGPI 10 ≥10 diária AGM, , (AGM) 20 AGS, (AGS) 7 <7% 5 5% Resultados 1482 (148 62,9% 629 62 9 [62,9%] prevalente 65 28% 28 (28% 178 (17 7,6% 76 6 [7,6%] ( 0,2%. 02 0,2% 0 2 [0,2%]) p =0,269. 0269 =0,269 269 =0,269) 38,42%, 3842 38,42% 38 42 (38,42%) 3,52% 352 3 52 (3,52% <0,001 0001 001 demais Conclusões avaliada evidenciouse evidenciou 23 1 ≥1 (AGM (AGS <7 148 (14 62,9 [62,9% (28 17 (1 7,6 [7,6% 0,2 [0,2%] 026 =0,26 26 384 38,42 4 (38,42% 3,52 35 (3,52 <0,00 000 00 ≥ < 14 62, [62,9 (2 7, [7,6 0, [0,2% =0,2 38,4 (38,42 3,5 (3,5 <0,0 [62, [7, [0,2 =0, 38, (38,4 3, (3, <0, [62 [7 [0, =0 (38, (3 <0 [6 [ [0 = (38

RESUMEN. El objetivo de este estudio ha sido analizar, a partir de la experiencia de los hombres que hacen sexo con hombres, cuáles son los aspectos que influyen en la decisión de usar o no usar el preservativo. Este es un estudio cualitativo exploratorio con 20 hombres, usuarios de un Centro de Pruebas y Asesoramiento en Porto Alegre. Las entrevistas realizadas fueron analizadas desde la perspectiva del análisis discursivo. El análisis indica que la gestión del riesgo, el uso y la no utilización del preservativo, se lleva a cabo en un contexto de negociación - no siempre explícito - en el que el valor atribuido al sexo, al otro y a uno mismo en la escena erótica interfiere en la decisión de usar o no el preservativo. Estas negociaciones y el valor atribuido al otro y a uno mismo, operan y también a partir de marcadores sociales, en una lógica económica, aunque no monetaria. En este contexto, la belleza, la apariencia, no tener una ‘cara de ETS (Enfermedades de Transmisión Sexual)’, así como ciertas prácticas sexuales y patrones heteronormativos aparecen en la escena homoerótica, a menudo reproduciendo relaciones de poder e influyendo en la gestión y en el uso del preservativo. Construir espacios para la reflexión sobre la erótica como algo que no solo es privado, sino también público y que reproduce relaciones de poder, puede ser una oportunidad para politizar la erótica y reflexionar sobre la gestión de riesgos y cuidados. RESUMEN analizar preservativo 2 Alegre discursivo riesgo sociales económica monetaria belleza apariencia cara Enfermedades Sexual, Sexual , Sexual)’ homoerótica privado cuidados Sexual)

ABSTRACT. This study aims to analyze, based on the experiences of men who have sex with men, what aspects influenced the use and non-use of condoms. This investigation is a qualitative, exploratory study with 20 men assisted by the Testing and Counseling Center (Centro de Testagem e Aconselhamento - CTA) in Porto Alegre. The data were produced from interviews analyzed from the perspective of discursive analysis. The findings indicate that risk management concerning the use and non-use of condoms occurs in a context of negotiation - not always explicit - in which the value attributed to sex to the other and oneself in the erotic scene interferes with the decision of condom use. These negotiations and the value attributed to the other and oneself also operate and are produced from social markers, in an economic logic, albeit non-monetary. In this context, beauty, appearance, not having an ‘STD (sexually transmitted disease) face’, as well as certain sexual practices and heteronormative patterns arise in the homoerotic scene, often reproducing power relations and influencing risk management and condom use. Building spaces for reflection on erotica as both private and public and reproductive of power relations can be an opportunity for the erotica politicization and reflection on risk and care management. ABSTRACT analyze nonuse non qualitative 2 Centro CTA Alegre analysis markers logic nonmonetary. nonmonetary monetary. monetary non-monetary beauty appearance STD sexually disease face, face , face’

RESUMO. O objetivo do estudo é analisar, com base na da vivência de homens que fazem sexo com homens, quais são os aspectos que influenciam na decisão de usar ou não o preservativo. Trata-se de um estudo qualitativo, de caráter exploratório com 20 homens, atendidos por um Centro de Testagem e Aconselhamento em Porto Alegre. O material foi produzido a partir de entrevistas analisadas sob a perspectiva da análise discursiva. A análise indica que a gestão de risco, do uso e não uso do preservativo, se dá em um contexto de negociação - nem sempre explícita - no qual o valor atribuído ao sexo, ao outro e a si mesmo na cena erótica interfere na decisão do uso do preservativo. Essas negociações e o valor atribuído ao outro e a si operam e se produzem também a partir de marcadores sociais, numa lógica econômica, ainda que não monetária. Neste contexto, a beleza, a aparência, o não ter ‘cara de DST (doenças sexualmente transmissíveis)’, bem como determinadas práticas sexuais e padrões heteronormativos surgem na cena homoerótica, muitas vezes reproduzindo relações de poderes e influenciando na gestão de risco e uso do preservativo. Construir espaços de reflexão sobre a erótica como algo da dimensão não apenas privada, mas também pública e reprodutora de relações de poder, pode ser uma oportunidade de politização da erótica e reflexão sobre a gestão de risco e cuidado. RESUMO analisar preservativo Tratase Trata qualitativo 2 Alegre discursiva sociais econômica monetária beleza aparência cara doenças transmissíveis, transmissíveis , transmissíveis)’ homoerótica privada poder cuidado transmissíveis)

Short-chain chiral esters are important constituents in natural fruit flavors, as well as in food and pharmaceutical industries. Different chemical and bio-catalytic routes are used for their synthesis, but the use of simultaneous techniques has not been much explored, as combinatorial synthesis and bio-catalysis in continuous-flow systems. Here, the objective was to synthesize chiral esters typically found in fruit flavors, to obtain chemical libraries with high conversion and enantiomeric excess, using combinations of these three techniques. Combinatorial synthesis in continuous-flow coil-type reactors with fix bed was used in the esterification of the secondary alcohols 2-butanol (1a), 2-pentanol (1b), 3-hexanol (1c), 2-heptanol (1d) and 2-octanol (1e) with acetic (2) and propanoic (3) acids. A surface-response method was applied to optimize the reaction conditions. Conversions were above 88% after 60 min for the reaction with chemical catalysts in continuous-flow reactors compared to 85%, but after 120 min, when conventional batch processes were used. By applying a biocatalyst, a chemical library of R acetates was prepared, with conversions over 48% after 48 h for batch and 40% after only 70 min for continuous flow reactions. It was observed that both enzymatic and homogeneous chemical catalysis showed to be viable for the chiral esters. Shortchain Short chain flavors industries biocatalytic bio catalytic explored biocatalysis continuousflow systems Here excess coiltype coil type 2butanol butanol 2 1a, 1a , (1a) 2pentanol pentanol 1b, 1b b (1b) 3hexanol hexanol 3 1c, 1c c (1c) 2heptanol heptanol 1d d (1d 2octanol octanol 1e e (1e (2 (3 acids surfaceresponse surface response conditions 88 6 85 85% 12 biocatalyst prepared 4 40 7 reactions (1a (1b (1c ( 8 1

Objective: We aimed to translate and determine cultural validity of the Vaginal Changes Sexual and Body Esteem Scale (VSBE) for Brazilian Portuguese language in postpartum women who underwent vaginal delivery with or without perineal laceration and cesarean section. Methods: A cross-sectional study conducted virtually, with online data collection through a survey with 234 postpartum women of 975 that were invited. Clinical, sociodemographic, and psychometric variables from the VSBE questionnaire were analyzed (content validity index, internal consistency, test-retest reliability, construct/structural and discriminant validity). Multivariate analysis was performed to explore associated factors with the presence of perineal laceration. Results: One-hundred fifty-eight women experienced vaginal delivery, of which 24.79% had an intact perineum, 33.33% had perineal laceration, and 9.4% underwent episiotomy; and 76 participants had cesarean sections. Women with perineal laceration were older, presented dyspareunia and previous surgeries than women without perineal laceration (p<0.05). For VSBE, a high internal consistency (Cronbach's α > 0.7) was observed, but it did not correlate with Body Attractiveness Questionnaire and Female Sexual Function Index; however, it correlated with the presence of women sutured for perineal laceration. Moreover, VSBE presented good structural validity with two loading factors after exploratory factor analysis. VSBE also demonstrated discriminant validity between the presence or absence of perineal laceration. The presence of urinary incontinence (UI) (OR=2.716[1.015-4.667];p=0.046) and a higher VSBE total score (OR=1.056[1.037-1.075];p<0.001) were the only factors associated with perineal laceration. Conclusion: Vaginal Changes Sexual and Body Esteem Scale demonstrated appropriate translation and good internal consistency, discriminant/construct validity and reliability. Vaginal Changes Sexual and Body Esteem Scale total score and presence of UI were associated with women that underwent perineal laceration. Objective (VSBE section Methods crosssectional cross sectional virtually 23 97 invited Clinical sociodemographic content index testretest test retest reliability constructstructural construct validity. . validity) Results Onehundred One hundred fiftyeight fifty eight 2479 24 79 24.79 perineum 3333 33 33.33 94 9 4 9.4 episiotomy 7 sections older p<0.05. p005 p p<0.05 0 05 (p<0.05) Cronbachs Cronbach s 0.7 07 observed Index however Moreover (UI OR=2.7161.0154.667p=0.046 OR271610154667p0046 ORp OR=2.716 1.015 4.667 p=0.046 OR 2 716 1 015 667 046 (OR=2.716[1.015-4.667];p=0.046 OR=1.0561.0371.075p<0.001 OR105610371075p0001 OR=1.056 1.037 1.075 p<0.001 056 037 075 001 (OR=1.056[1.037-1.075];p<0.001 Conclusion discriminantconstruct 247 24.7 333 3 33.3 9. p00 p<0.0 (p<0.05 0. 7161 0154 667p OR=2.7161.0154.667p=0.04 OR271610154667p004 OR2716 OR=2.71 1015 1.01 4667 4.66 p0046 p=0.04 71 01 66 04 (OR=2.716[1.015-4.667];p=0.04 0561 0371 075p OR=1.0561.0371.075p<0.00 OR105610371075p000 OR1056 OR=1.05 1037 1.03 1075 1.07 p0001 p<0.00 03 00 (OR=1.056[1.037-1.075];p<0.00 24. 33. p0 p<0. (p<0.0 OR=2.7161.0154.667p=0.0 OR271610154667p00 OR271 OR=2.7 101 1.0 466 4.6 p004 p=0.0 6 (OR=2.716[1.015-4.667];p=0.0 OR=1.0561.0371.075p<0.0 OR105610371075p00 OR105 OR=1.0 103 107 p000 (OR=1.056[1.037-1.075];p<0.0 p<0 (p<0. OR=2.7161.0154.667p=0. OR271610154667p0 OR27 OR=2. 10 1. 46 4. p=0. (OR=2.716[1.015-4.667];p=0. OR=1.0561.0371.075p<0. OR105610371075p0 OR10 OR=1. (OR=1.056[1.037-1.075];p<0. p< (p<0 OR=2.7161.0154.667p=0 OR271610154667p OR2 OR=2 p=0 (OR=2.716[1.015-4.667];p=0 OR=1.0561.0371.075p<0 OR105610371075p OR1 OR=1 (OR=1.056[1.037-1.075];p<0 (p< OR=2.7161.0154.667p= OR= p= (OR=2.716[1.015-4.667];p= OR=1.0561.0371.075p< (OR=1.056[1.037-1.075];p< (p OR=2.7161.0154.667p (OR=2.716[1.015-4.667];p OR=1.0561.0371.075p (OR=1.056[1.037-1.075];p

ABSTRACT Purpose: To evaluate the saccadic movements of patients with visual field loss due to primary open-angle glaucoma. Methods: Thirteen patients with good visual acuity (0.2 logMAR or better) (seven patients with primary open-angle glaucoma 65 ± 13 years) and six controls (51 ± 6 years) yielded a comprehensive ophthalmological examination, including Humphrey Visual Field tests (SITA-Standard 24-2), and performed a monocular, exploratory digital visual search task that quantifies the duration for finding the number “4” on a random array of digits distributed on the screen. After individual adjustments of the angle and distance positioning, the screen was spatially matched with the 24-2 visual field, and divided into five areas for analysis. During the task, saccades were simultaneously recorded in the same eye with a video-based eye tracker. Results: The patients with primary open-angle glaucoma showed a significantly higher number of saccades/screen (median ± interquartile range, 59.00 ± 29.00 vs. 32.50 ± 19.75 saccades (p=0.027) and visual search time per screen (38.50 ± 60.14 vs. 23.75 ± 8.90 seconds (p=0.035) than the controls did. Although the univariate analysis indicated a significant correlation with visual field mean deviation (coefficient=26.19 (p=0.02), only the visual search time/screen was significantly associated with the number of saccades/screen in the multivariate regression model (coefficient=0.55 (p<0.001). Overall, no significant correlation was observed between the sectorial number of saccades and the sensitivity of the five visual field areas. Conclusions: The patients with primary open-angle glaucoma show impaired search performance and showed a higher number of saccades needed to find stimuli when performing the exploratory visual task. Purpose openangle open Methods 0.2 02 0 2 (0. better seven 1 years 51 (5 examination SITAStandard SITA Standard 242, 242 24 , 24-2) monocular 4 “4 positioning 24- videobased video based tracker Results saccadesscreen median range 5900 59 00 59.0 2900 29 29.0 vs 3250 32 50 32.5 1975 19 75 19.7 p=0.027 p0027 p 027 (p=0.027 38.50 3850 38 (38.5 6014 60 14 60.1 2375 23 23.7 890 8 90 8.9 p=0.035 p0035 035 (p=0.035 did coefficient=26.19 coefficient2619 coefficient 26 (coefficient=26.1 p=0.02, p002 p=0.02 (p=0.02) timescreen coefficient=0.55 coefficient055 55 (coefficient=0.5 p<0.001. p0001 p<0.001 . 001 (p<0.001) Overall Conclusions 0. (0 5 ( “ 590 59. 290 29. 325 3 32. 197 7 19. (p=0.02 38.5 385 (38. 601 60. 237 23. 89 9 8. p=0.03 p003 03 (p=0.03 coefficient=26.1 coefficient261 (coefficient=26. p00 p=0.0 coefficient=0.5 coefficient05 (coefficient=0. p000 p<0.00 (p<0.001 (p=0.0 38. (38 coefficient=26. coefficient26 (coefficient=26 p0 p=0. coefficient=0. coefficient0 (coefficient=0 p<0.0 (p<0.00 (p=0. (3 coefficient=26 coefficient2 (coefficient=2 p=0 coefficient=0 (coefficient= p<0. (p<0.0 (p=0 coefficient=2 p= coefficient= (coefficient p<0 (p<0. (p= p< (p<0 (p (p<

SUMMARY OBJECTIVE: The aim of this study was to assess medical students’ quality of sleep and excessive daytime sleepiness in different graduation cycles. METHODS: A cross-sectional study was carried out at a private university in Maceió, Brazil, from August 2021 to March 2022. The sample was composed of medical students aged 18 years and above from years 1–2 (basic cycle), 3–4 (clinical cycle), and 5–6 (internship) of Medical School who were invited to answer two validated questionnaires: the Pittsburgh Sleeping Quality Index and the Epworth Sleepiness Scale. RESULTS: A total of 179 students participated; most of them were female (78.2%), aged 19–25 years (73.7%), and with a body mass index<25 kg/m2 (73.7%), with smaller participation from students from the basic cycle (21.2%). Analyzing the Pittsburgh Sleeping Quality Index, 55.9% of the students were classified as having poor sleep quality, with no difference in sleep category between gender, age, body mass index, and graduation cycle. Students with a body mass index of ≥25 kg/m2 had longer sleep latency (p=0.016) and shorter sleep duration (p=0.027). The Epworth Sleepiness Scale assessment showed that 44.1% of the students exhibit daytime sleepiness. Women had more daytime sleepiness than men (p=0.017), with no difference between age, body mass index, and graduation cycle. CONCLUSION: About half of the medical students experience poor sleep quality and daytime sleepiness, regardless of the graduation cycle. This should trigger a targeted institutional intervention to promote better mental and physical health, as well as sleep hygiene, to reduce future health issues. OBJECTIVE cycles METHODS crosssectional cross sectional Maceió Brazil 202 2022 1 12 2 1– cycle, , cycle) 34 3 4 3– clinical 56 5 6 5– internship (internship questionnaires RESULTS 17 participated 78.2%, 782 78.2% 78 (78.2%) 1925 19 25 19–2 73.7%, 737 73.7% 73 7 (73.7%) index25 index<2 kgm2 kgm kg m2 m kg/m 21.2%. 212 21.2% . 21 (21.2%) 559 55 9 55.9 gender age ≥2 p=0.016 p0016 p 0 016 (p=0.016 p=0.027. p0027 p=0.027 027 (p=0.027) 441 44 44.1 p=0.017, p0017 p=0.017 017 (p=0.017) CONCLUSION hygiene issues 20 78.2 (78.2% 192 19– 73.7 (73.7% index2 index< 21.2 (21.2% 55. ≥ p=0.01 p001 01 (p=0.01 p002 p=0.02 02 (p=0.027 44. (p=0.017 78. (78.2 73. (73.7 21. (21.2 p=0.0 p00 (p=0.0 (p=0.02 (78. (73. (21. p=0. p0 (p=0. (78 (73 (21 p=0 (p=0 (7 (2 p= (p= ( (p

Abstract Sand flies, vectors capable of transmitting Leishmania spp. and causing leishmaniasis, have been a concern in the central region of Rio Grande do Sul, where canine leishmaniasis (CanL) has been documented since 1985. Notably, there has been a surge in CanL cases since 2017, with two autochthonous cases of human visceral leishmaniasis reported in the area in 2021. This study aimed to identify the sand fly fauna potentially involved in disease transmission. Modified Centers for Disease Control light traps were deployed in three neighborhoods of the city where CanL cases had been previously reported, spanning January 2021 to December 2022. Of the 89 collections conducted, 119 sand flies belonging to five species were captured: Pintomyia fischeri (76/119, 63.86%), Migonemyia migonei (23/119, 19.33%), Lutzomyia longipalpis (16/119, 13.45%), Brumptomyia sp. (2/119, 1.68%), and Psathyromyia lanei (2/119, 1.68%), predominantly between February and April in 2021 and 2022. Polymerase chain reaction testing on all female specimens yielded negative results for Leishmania spp. DNA. Although Leishmania spp. was not detected in these vectors, these findings underscore the imperative to implement measures aimed at curtailing the proliferation of these insects. spp Sul (CanL 1985 Notably 2017 transmission 202 2022 8 conducted 11 captured 76/119, 76119 76 (76/119 63.86%, 6386 63.86% , 63 86 63.86%) 23/119, 23119 23 (23/119 19.33%, 1933 19.33% 19 33 19.33%) 16/119, 16119 16 (16/119 13.45%, 1345 13.45% 13 45 13.45%) sp 2/119, 2119 2 (2/119 1.68%, 168 1.68% 1 68 1.68%) DNA insects 198 201 20 76/119 7611 7 (76/11 638 63.86 6 23/119 2311 (23/11 193 19.33 3 16/119 1611 (16/11 134 13.45 4 2/119 211 (2/11 1.68 76/11 761 (76/1 63.8 23/11 231 (23/1 19.3 16/11 161 (16/1 13.4 2/11 21 (2/1 1.6 76/1 (76/ 63. 23/1 (23/ 19. 16/1 (16/ 13. 2/1 (2/ 1. 76/ (76 23/ (23 16/ (16 2/ (2 (7 (1 (

Resumo Os flebotomíneos, vetores capazes de transmitir Leishmania spp. e causar leishmaniose, têm sido uma preocupação na região central do Rio Grande do Sul, onde a leishmaniose canina (CanL) é documentada desde 1985. Notavelmente, houve um aumento nos casos de CanL desde 2017, com dois casos autóctones de leishmaniose visceral humana relatados na área, em 2021. Este estudo teve como objetivo identificar a fauna de flebotomíneos potencialmente envolvida na transmissão da doença. Armadilhas luminosas modificadas, do Centro de Controle de Doenças, foram implantadas em três bairros da cidade onde casos de CanL haviam sido relatados anteriormente, no período de janeiro de 2021 a dezembro de 2022. Das 89 coletas realizadas, 119 flebotomíneos de cinco espécies foram capturados: Pintomyia fischeri (76/119, 63,86%), Migonemyia migonei (23/119, 19,33%), Lutzomyia longipalpis (16/119, 13,45%), Brumptomyia sp. (2/119, 1,68%) e Psathyromyia lanei (2/119, 1,68%), predominantemente, entre fevereiro e abril de 2021 e 2022. Testes de reação em cadeia da polimerase em todos os espécimes fêmeas resultaram negativos para DNA de Leishmania spp. Embora Leishmania spp. não tenha sido detectada nesses vetores, esses achados destacam a necessidade imperativa de implementar medidas destinadas a conter a proliferação desses insetos. spp Sul (CanL 1985 Notavelmente 2017 área doença modificadas Doenças anteriormente 202 2022 8 realizadas 11 capturados 76/119, 76119 76 (76/119 63,86%, 6386 63,86% , 63 86 63,86%) 23/119, 23119 23 (23/119 19,33%, 1933 19,33% 19 33 19,33%) 16/119, 16119 16 (16/119 13,45%, 1345 13,45% 13 45 13,45%) sp 2/119, 2119 2 (2/119 1,68% 168 1 68 1,68%, predominantemente insetos 198 201 20 76/119 7611 7 (76/11 638 63,86 6 23/119 2311 (23/11 193 19,33 3 16/119 1611 (16/11 134 13,45 4 2/119 211 (2/11 1,68 76/11 761 (76/1 63,8 23/11 231 (23/1 19,3 16/11 161 (16/1 13,4 2/11 21 (2/1 1,6 76/1 (76/ 63, 23/1 (23/ 19, 16/1 (16/ 13, 2/1 (2/ 1, 76/ (76 23/ (23 16/ (16 2/ (2 (7 (1 (

Abstract Currently, the market for organic products is in growing demand, and consumers seek to be in tune with the proposal of organic cultivation. The main reasons for this demand are related to the environment and health. Therefore, in the same proportion, there are studies in the literature addressing the subject. Thus, packaging has become an important vehicle for food, with the emergence of alternative materials to the use of conventional plastic. This study reports, within the profile of the consumer in the South and Southeast regions of Brazil, the probability of the consumer to purchasing organic packaging, as an alternative, for food products. For the present study, 328 questionnaires were used, consisting of 17 open and multiple-choice questions that addressed socioeconomic issues, consumption of organic and conventional foods, and the probability of using organic packaging. The profile of the consumer of organic products is predominantly women, with a postgraduate degree, between 31 and 40 years old and with a family income of 4 to 6 minimum wages. About organic packaging, there is a high probability that the consumer will purchase it with or without adding cost to the final value. Currently cultivation health Therefore proportion subject Thus plastic reports Brazil 32 used 1 multiplechoice multiple choice issues foods women degree 3 wages value

Resumen La salud del trabajador migrante en la ruta bioceánica requiere acciones integrales, siendo necesario comprender sus problemas y agravios. Este es un artículo de reflexión teórica cuyo objetivo fue comprender las posibilidades de las acciones de vigilancia en salud del trabajador en situaciones de migración en la ruta bioceánica en Mato Grosso do Sul. Para una identificación desses elementos, utilizou-se a revision narrativa da literatura, à luz de um referencial teórico. Utilizou-se o portal State National Library of Medicine National Institutes of Health (Medline/PubMed), aplicando os termos: “Vigilancia de la Salud de los Trabajadores”; “Vulnerabilidad en Salud”; “Transitorios y Migrantes”; combinados con el operador boleeano “AND”. Se identificaron cinco aspectos que componen la vigilancia en salud del trabajador: asistencia, vigilancia, notificación, planificación y gestión. En el contexto de la asistencia, es crucial proporcionar acceso a servicios de salud, incluyendo atención de emergencia, cuidados materno-infantiles y tratamiento de enfermedades transmisibles y relacionadas con el trabajo. La vigilancia de la salud debe centrarse en la prevención y promoción de la salud a través de acciones basadas en la identificación de riesgos ocupacionales, accidentes y enfermedades relacionadas con el trabajo. La recolección y análisis de datos epidemiológicos son fundamentales para orientar las acciones de vigilancia e implementar medidas adecuadas, lo cual es posible mediante notificaciones. Para la planificación y gestión, es necesario fortalecer las alianzas con dispositivos sociales, mejorar la red de atención a la salud del trabajador y regularizar el trabajo de estos migrantes para combatir prácticas precarias e ilegales. Conclui-se que las políticas públicas deben ser dirigidas a las dimensiones que compõem a vigilância em saúde do trabalhador, visando assegurar melhores condições de life aos migrantes trabalhadores na rota bioceânica. integrales agravios Sul elementos utilizouse utilizou se literatura teórico Utilizouse Utilizou Medline/PubMed, MedlinePubMed Medline/PubMed , Medline PubMed (Medline/PubMed) termos Vigilancia Trabajadores Trabajadores” Vulnerabilidad Salud” Transitorios Migrantes Migrantes” AND. AND . “AND” asistencia notificación gestión emergencia maternoinfantiles materno infantiles ocupacionales adecuadas notificaciones sociales ilegales Concluise Conclui trabalhador bioceânica (Medline/PubMed “AND

Abstract The health of migrant workers on the Bioceanic Route requires comprehensive actions, and it is necessary to understand their issues and problems. This is a theoretical reflection article whose objective was to comprehend the possibilities of health surveillance actions for workers in migration situations on the Bioceanic Route in Mato Grosso do Sul. For the identification of these elements, a narrative review of the literature was used, in light of a theoretical framework. Use the portal States National Library of Medicine National Institutes of Health (Medline/PubMed), applying the terms: “Surveillance of the Workers Health”; “Health Vulnerability”; “Transients and Migrants”; combined with the Boolean operator “AND”. Five aspects that constitute health worker surveillance were identified: assistance, surveillance, notification, planning, and management. In the context of assistance, it is crucial to provide access to health services, including emergency care, maternal and child care, and treatment of communicable and work-related diseases. Health surveillance should focus on prevention and health promotion through actions centered on identifying occupational risks, accidents, and work-related illnesses. The collection and analysis of epidemiological data are essential to guide surveillance actions and implement appropriate measures, made possible through notifications. For planning and management, it is necessary to strengthen partnerships with social devices, enhance the worker health care network, and regularize the work of these migrants to combat precarious and illegal practices. It is concluded that public policies should be addressed to the dimensions that make up the surveillance of the worker's health, aiming to ensure better living conditions for migrant workers in the Bioceanic Route. problems Sul elements used framework Medline/PubMed, MedlinePubMed Medline/PubMed , Medline PubMed (Medline/PubMed) terms Surveillance Health” Vulnerability Vulnerability” Transients Migrants Migrants” AND. AND . “AND” identified assistance notification management services workrelated related diseases risks accidents illnesses measures notifications devices network practices s (Medline/PubMed “AND

Resumo A saúde dos trabalhadores migrantes na Rota Bioceânica requer ações abrangentes, e é necessário compreender seus problemas e agravos. Este ensaio tem o objetivo de compreender as possibilidades de ações de vigilância da saúde dos trabalhadores em situações de migração na Rota Bioceânica em Mato Grosso do Sul. Para identificar esses elementos, foi utilizada uma revisão narrativa da literatura considerando um referencial teórico. Utilizou-se o portal States National Library of Medicine National Institutes of Health (Medline/ PubMed), aplicando os termos: “Surveillance of the Workers Health”; “Health Vulnerability”; “Transients and Migrants”; combinados com o operador booleano “AND”. Foram identificados cinco aspectos que compõem a vigilância em saúde do trabalhador: assistência, vigilância, notificação, planejamento e gestão. No contexto da assistência, é crucial fornecer acesso aos serviços de saúde, incluindo atendimento emergencial, cuidados materno-infantis e tratamento de doenças transmissíveis e relacionadas ao trabalho. A vigilância da saúde deve focar na prevenção e promoção da saúde com ações pautadas na identificação de riscos ocupacionais, acidentes e doenças relacionadas ao trabalho. A coleta e análise de dados epidemiológicos são fundamentais para direcionar ações de vigilância e implementar medidas adequadas, possível por meio das notificações. Para o planejamento e gestão deve-se fortalecer parcerias com dispositivos sociais, e a rede de atenção à saúde do trabalhador, regularizando o trabalho e combatendo práticas precárias e ilegais. Conclui-se que políticas públicas devem ser direcionadas às dimensões que compõem a vigilância em saúde do trabalhador, visando assegurar melhores condições de vida aos migrantes trabalhadores na rota bioceânica. abrangentes agravos Sul elementos teórico Utilizouse Utilizou se Medline/ Medline (Medline PubMed, PubMed , PubMed) termos Surveillance Health” Vulnerability Vulnerability” Transients Migrants Migrants” AND. AND . “AND” trabalhador assistência notificação emergencial maternoinfantis materno infantis ocupacionais adequadas notificações devese sociais ilegais Concluise Conclui bioceânica “AND

ABSTRACT Objective To compare two methods for defining and classifying the severity of pediatric acute respiratory distress syndrome: the Berlin classification, which uses the relationship between the partial pressure of oxygen and the fraction of inspired oxygen, and the classification of the Pediatric Acute Lung Injury Consensus Conference, which uses the oxygenation index. Methods This was a prospective study of patients aged 0 - 18 years with a diagnosis of acute respiratory distress syndrome who were invasively mechanically ventilated and provided one to three arterial blood gas samples, totaling 140 valid measurements. These measures were evaluated for correlation using the Spearman test and agreement using the kappa coefficient between the two classifications, initially using the general population of the study and then subdividing it into patients with and without bronchospasm and those with and without the use of neuromuscular blockers. The effect of these two factors (bronchospasm and neuromuscular blocking agent) separately and together on both classifications was also assessed using two-way analysis of variance. Results In the general population, who were 54 patients aged 0 - 18 years a strong negative correlation was found by Spearman’s test (ρ -0.91; p < 0.001), and strong agreement was found by the kappa coefficient (0.62; p < 0.001) in the comparison between Berlin and Pediatric Acute Lung Injury Consensus Conference. In the populations with and without bronchospasm and who did and did not use neuromuscular blockers, the correlation coefficients were similar to those of the general population, though among patients not using neuromuscular blockers, there was greater agreement between the classifications than for patients using neuromuscular blockers (kappa 0.67 versus 0.56, p < 0.001 for both). Neuromuscular blockers had a significant effect on the relationship between the partial pressure of oxygen and the fraction of inspired oxygen (analysis of variance; F: 12.9; p < 0.001) and the oxygenation index (analysis of variance; F: 8.3; p = 0.004). Conclusion There was a strong correlation and agreement between the two classifications in the general population and in the subgroups studied. Use of neuromuscular blockers had a significant effect on the severity of acute respiratory distress syndrome. Conference 1 samples 14 measurements agent twoway way variance 5 Spearmans s ρ 0.91 091 91 -0.91 0.001, 0001 , 001 0.62 062 62 (0.62 067 67 0.6 056 56 0.56 0.00 both. . both) F 12.9 129 12 9 8.3 83 8 3 0.004. 0004 0.004 004 0.004) studied 0.9 09 -0.9 000 00 06 6 (0.6 0. 05 0.5 0.0 12. 8. -0. (0. -0 (0 (

RESUMO Objetivo Comparar dois métodos para definição e classificação de gravidade na síndrome do desconforto respiratório agudo pediátrica: a classificação de Berlim, que utiliza a relação entre pressão parcial de oxigênio e fração inspirada de oxigênio e a classificação do Pediatric Acute Lung Injury Consensus Conference, que utiliza o índice de oxigenação. Métodos Estudo prospectivo com pacientes de 0 - 18 anos com diagnóstico de síndrome do desconforto respiratório agudo e ventilados mecanicamente de forma invasiva, que forneceram de uma a três amostras de gasometria arterial, totalizando 140 medidas válidas. Essas medidas foram avaliadas quanto à correlação pelo teste de Spearman e à concordância pelo coeficiente kappa entre as duas classificações, inicialmente usando a população geral do estudo e, depois, subdividindo-a em pacientes com e sem broncoespasmo e com e sem o uso do bloqueador neuromuscular. Também foi verificado o efeito desses dois fatores (broncoespasmo e bloqueador neuromuscular) de forma separada e conjunta sobre ambas as classificações por meio da análise de variância para dois fatores. Resultados Na população geral, composta de 54 pacientes com idades de 0 - 18 anos, foi encontrada forte correlação negativa pelo teste de Spearman (ρ -0,91; p < 0,001) e forte concordância pelo coeficiente kappa (0,62; p < 0,001) na comparação entre Berlim e Pediatric Acute Lung Injury Consensus Conference. Nas populações com e sem broncoespasmo e com e sem o uso do bloqueador neuromuscular, os coeficientes de correlação mantiveram valores semelhantes aos da população geral. Entretanto, para os pacientes sem uso do bloqueador neuromuscular, houve maior concordância entre as classificações em relação aos pacientes com uso do bloqueador neuromuscular (kappa 0,67 versus 0,56 com p < 0,001 em ambos). Acrescenta-se ainda o efeito significativo do uso do bloqueador neuromuscular sobre a relação entre pressão parcial de oxigênio e fração inspirada de oxigênio (análise de variância; F: 12,9; p < 0,001) e o índice de oxigenação (análise de variância; F: 8,3; p = 0,004). Conclusão Houve forte correlação e concordância entre as duas classificações na população geral e nos subgrupos estudados, entretanto, há efeito significativo do uso do bloqueador neuromuscular sobre as classificações de gravidade da síndrome do desconforto respiratório agudo. pediátrica Conference 1 invasiva arterial 14 válidas depois subdividindoa subdividindo 5 ρ 0,91 091 91 -0,91 0001 001 0,62 062 62 (0,62 Entretanto 067 67 0,6 056 56 0,5 0,00 ambos. ambos . ambos) Acrescentase Acrescenta se F 12,9 129 12 9 8,3 83 8 3 0,004. 0004 0,004 004 0,004) estudados entretanto 0,9 09 -0,9 000 00 06 6 (0,6 0, 05 0,0 12, 8, -0, (0, -0 (0 (