ABSTRACT Objective: Thymidine-dependent small-colony variants (TD-SCVs) of Staphylococcus aureus are being isolated with increasing frequency from patients with cystic fibrosis (CF). The aim of this study was to evaluate the relationship between TD-SCV isolation and pulmonary function in patients with CF, as well as to determine whether the emergence of TD-SCVs was associated with trimethoprim-sulfamethoxazole (TMP-SMX) use and with coinfection with other microorganisms. Methods: This was a retrospective case-control study including patients with CF who visited the Clinical Hospital Complex of the Federal University of Paraná, in Curitiba, Brazil, between 2013 and 2022. Demographic, clinical, and spirometric data, as well as information on TD-SCVs and other isolated microorganisms, were collected from the medical records of patients with CF and TD-SCVs (TD-SCV group; n = 32) and compared with those of a matched group of patients with CF without TD-SCVs (control group; n = 64). Results: Isolation of TD-SCVs was positively associated with TMP-SMX use (p = 0.009), hospitalization (p < 0.001), and impaired pulmonary function (p = 0.04). Conclusions: The use of TMP-SMX seems to contribute to the emergence of TD-SCVs, the isolation of which was directly associated with worse pulmonary function in our sample. Objective Thymidinedependent Thymidine dependent smallcolony small colony TDSCVs TD SCVs (TD-SCVs CF. . (CF) TDSCV SCV trimethoprimsulfamethoxazole trimethoprim sulfamethoxazole TMPSMX TMP SMX (TMP-SMX microorganisms Methods casecontrol case control Paraná Curitiba Brazil 201 2022 Demographic clinical data 32 64. 64 64) Results p 0.009, 0009 0.009 , 0 009 0.009) 0.001, 0001 0.001 001 0.001) 0.04. 004 0.04 04 0.04) Conclusions TDSCVs, SCVs, sample (CF 20 202 3 6 000 0.00 00 0.0 2 0.

Avaliados no Ambulatório Especial da Área de Doenças Tropicais, da Faculdade de Medicina de Botucatu, UNESP, 31 indivíduos com infecção pelo HIV-1. Dezesseis realizaram avaliações psicológicas em momentos distintos, sendo utilizados o Teste de Relações Objetais a Escala Diagnóstica Adaptativa Operacionalizada. Verificou-se associações entre dados epidemiológicos, clínicos, laboratoriais e psicodinâmicos, considerando a história natural da doença. A infecção adquirida por consumo de drogas, implicou desenvolvimento de aids, doenças neurológicas, internações e adaptação ineficaz grave. Indivíduos com: aids, predomínio do funcionamento psicótico da mente, gravidez e/ou sexualidade precoce, impulsividade e irritabilidade apresentaram deterioração da eficácia adaptativa ao longo do tempo. Pacientes com ideação suicida e/ou adaptação ineficaz severa ou grave apresentam linha de tendência do CD4+ e CD8+ em queda e carga viral alta. A maior parte apresentou depressão crônica do tipo psicótica. Observou-se correlação positiva entre TRO e EDAO-R, TRO e CD4+, e EDAO-R e CD8+.

Thirty-one individuals with HIV-1 infection were evaluated in theAmbulatório Especial da Área de Doenças Tropicais, da Faculdade de Medicina of Botucatu, Brazil,UNESP. Sixteen went through psychological evaluations in different moments, being used the Object Relations Test and the Adaptive Operationalized Diagnostic Scale. Associations among epidemic, clinical, laboratorials and psychodynamics data, considering the natural history of the disease were verified. The infection acquired through drugs consumption, implied in aids development, neurological diseases, internments and serious ineffective adaptation. Individuals with: aids, prevalence of the psychotic operation of the mind, pregnancy and/or precocious sexuality, impulsivity and irritability presented deterioration of adaptive effectiveness along time. Patients with suicidal ideation and/or severe or serious ineffective adaptation present a falling line of tendency of CD4+ CD8+ and a high viral load. Most of them presented chronic depression of the psychotic type. Positive correlation was observed among TRO and EDAO-R, TRO and CD4 +, and EDAO-R and CD8+ was observed.

OBJETIVO: Avaliar a positividade do Phadiatop® em crianças acompanhadas em serviços brasileiros de alergologia e compará-la aos resultados de IgE sérica específica a alérgenos inalantes e alimentares. CASUÍSTICA E MÉTODO: Em 457 crianças acompanhadas em serviços de alergia pediátrica e um grupo de crianças controle não-alérgicas (n = 62), distribuídas em cinco faixas etárias, foram determinados em amostra de soro: Phadiatop® e IgE específica (RAST) a alérgenos inalantes e alimentares (UniCAP - Pharmacia®). RESULTADOS: O Phadiatop® foi positivo em 305 crianças atópicas (67,6%) e em 25,8% das controles (p < 0,001). Entre as crianças atópicas, a distribuição de positividade variou de acordo com a faixa etária: 7,9% (24/305) entre as abaixo de 2 anos, 15,4% (47/305) nas de 2 a 3 anos, 22,0% (67/305) nas de 3 a 4 anos, 19,3% (59/305) nas de 4 a 5 anos e 35,4% (108/305) nas de 5 a 12 anos. Não houve concordância entre os alérgenos alimentares e a presença de Phadiatop® positivo. O estudo da relação entre os RAST positivos para alérgenos inalados e o Phadiatop® positivo mostrou melhores índices com os ácaros domiciliares (D. pteronyssinus, D. farinae e Blomia tropicalis). CONCLUSÕES: O Phadiatop®é método útil no diagnóstico de alergia aos ácaros domiciliares.

OBJECTIVES: To evaluate the positivity of Phadiatop® in children from several Brazilian pediatric allergology centers and to compare its results with the presence of serum specific IgE to inhalant and food allergens. PATIENTS AND METHOD: Phadiatop® and serum specific IgE levels (RAST) to inhalant and food allergens (UniCAP - Pharmacia®) were measured in 457 children from several pediatric allergy centers and in a non-allergic control group (n = 62), distributed across five age groups. RESULTS: Phadiatop was positive in 305 atopic children (67.6%) and in 25.8% of controls (p < 0.001). Among atopic children the distribution of positive test varied according to age: 7.9% (24/305) among under 2 year-olds, 15.4% (47/305) in 2 to 3 year-olds, 22% (67/305) in 3 to 4 year-olds, 19.3% (59/305) in 4 to 5 year-olds and 35.4% (108/305) in 5 to 12 year-olds. No concordance between food allergens and Phadiatop® was observed. Analysis of the relationship between positive inhaled allergen RASTs and positive Phadiatop® showed best indices with house dust mites (D. pteronyssinus, D. farinae and Blomia tropicalis). CONCLUSIONS: Phadiatop® is a useful tool for diagnosing domestic mite allergy.

O presente trabalho investiga o Plano Preliminar de Urbanismo (PPU) instituído em 1965, matriz do Plano Diretor que transformou o espaço urbano de Curitiba na década de 70. A análise focaliza o discurso técnico e seu procedimento de classificação do espaço e da população da cidade. O saber técnico articulou-se fortemente às estratégias de divisão desigual do espaço e orientação diferenciada das políticas urbanas. Essa articulação pode ser constatada ao analisarmos a argumentação técnica mobilizada no PPU para definir a localização dos eixos estruturais, cujo efeito foi atribuir um valor suplementar a espaços já valorizados e formar um estoque para expansão seletiva do centro da cidade.

The present work investigates the Preliminary Urbanism Plan (Plano Preliminar de Urbanismo - PPU, 1965), source of the Directory Plan that has transformed Curitiba's urban space in the 1970's. The analysis focuses on the technical discourse and its procedure of classifying the city's space and population. The technical knowledge was strongly articulated to strategies of unequal division of space and differentiated orientation of urban policies. This articulation can be acknowledged as we analyze the technical arguments mobilized in the PPU in order to define the placement of the cities "structural axes", having the effect of attributing supplementary value to spaces already valorized and to build a stock of selective expansion in the city central area.

Ce travail étudie le Plan Préliminaire d'Urbanisme (PPU, 1965), origine du Plan Directeur qui a transformé l'espace urbain de Curitiba dans les années 70. L'analyse met en relief le discours technique et son procédé de classement de l'espace et de la population de la ville. Le savoir-faire s'est fortement associé aux stratégies de partage inégal de l'espace et orientation différenciée des politiques urbaines. Cette association peut être vérifiée en analysant l'argumentation technique utilisée au PPU en vue de définir la localisation des axes structuraux dont l'effet fut celui d'attribuer une valeur supplémentaire à l'espace déjà mis en valeur et de former un stock d'expansion sélective dans le centre de la ville.