ABSTRACT Purpose: This study aimed to characterize retinitis pigmentosa associated with the eyes shut homolog gene, which causes hereditary retinal degeneration. Methods: The anatomical and functional findings of retinitis pigmentosa in patients with variants of the eyes shut homolog gene were characterized and compared using multimodal imaging and genetic analysis of the variants. Clinical data such as visual acuity, lens status, and refraction were obtained from medical records. Patients underwent an ophthalmic examination, including static visual field, microperimetry, optical coherence tomography, fundus autofluorescence, and fundus photography. Results: Twenty-two patients were included in the study. Several anatomical and functional characteristics of retinitis pigmentosa-eyes shut homolog were identified, including the presence of cataracts, cystoid macular edema, epiretinal membrane, and a tubular visual field. Genetic results revealed 26 distinct variants in the cohort, with 7 novel variants not previously documented or reported in the scientific literature or databases. Conclusion: The findings demonstrate that eyes shut homolog-retinitis pigmentosa manifests in specific patterns, starting in adolescence with mild progression and advancing with age. The integration of multimodal imaging and genetic analysis has provided a detailed understanding of the anatomical and functional features of retinitis pigmentosa-eyes shut homolog. Seven novel variants of the eyes shut homolog gene have been identified. These findings enhance the understanding of eyes shut homolog-related retinitis pigmentosa characteristics of by detailing the spectrum of mutations in this gene within the Brazilian population. Purpose degeneration Methods acuity status records examination field microperimetry tomography autofluorescence photography Results Twentytwo Twenty two pigmentosaeyes identified cataracts edema membrane 2 cohort databases Conclusion homologretinitis patterns age homologrelated related population

Resumo Enquadramento: A participação da equipe de enfermagem nas intervenções educativas utilizando a metodologia da problematização melhora o conhecimento teórico, reduzindo o número de cateteres retirados precocemente. Objetivo: Avaliar o efeito da intervenção educativa na equipa de enfermagem na unidade de terapia intensiva pediátrica na melhoria do conhecimento teórico sobre a prevenção de complicações que ocasionam a remoção não eletiva do cateter central de inserção periférica. Metodologia: Estudo quase-experimental com aplicação de questionário antes e após intervenção educativa, com aplicação do teste t de Student Pareado, considerando-se o nível de significância de 95% e os valores de p < 0,05 significativos. Resultados: Aumento do conhecimento teórico após intervenção, com aumento da média da pontuação dos técnicos em enfermagem de 5,30 (DP = 1,49) para 9,10 (DP = 1,79) e enfermeiros de 11,83 (DP = 2,12) para 20,67 (DP = 2,46). Conclusão: Espera-se que esse conhecimento teórico sobre a prevenção de complicações se efetive no ato de cuidar, promovendo a melhoria da prática de manutenção e, consequentemente, redução das perdas prematuras do cateter.

Abstract Background: The nursing team’s participation in educational interventions using the problematization methodology improves theoretical knowledge, reducing the number of catheters removed early. Objective: To evaluate the effect of an educational intervention on the nursing team of a pediatric intensive care unit in improving theoretical knowledge about the prevention of complications resulting from the unplanned removal of peripherally inserted central catheters. Methodology: A quasi-experimental study was conducted using a questionnaire before and after the educational intervention. The paired Student’s t-test was applied, with a significance level of 95% and a p-value of p < 0.05. Results: Theoretical knowledge increased significantly after the educational intervention. The mean score for nursing technicians increased from 5.30 (SD = 1.49) to 9.10 (SD = 1.79), while the mean score for nurses increased from 11.83 (SD = 2.12) to 20.67 (SD = 2.46). Conclusion: The theoretical knowledge about the prevention of complications should be used to improve catheter maintenance practices and reduce premature catheter loss.

Resumen Marco contextual: La participación del equipo en la acción educativa, problematizando su realidad profesional, mejora los conocimientos teóricos, lo que permite reducir el número de catéteres retirados prematuramente. Objetivo: Evaluar el efecto de una intervención educativa para el equipo de enfermería de una unidad de cuidados intensivos pediátricos para mejorar los conocimientos teóricos sobre la prevención de las complicaciones que causan la retirada no electiva del catéter central de inserción periférica. Metodología: Estudio cuasiexperimental mediante cuestionario antes y después de la intervención educativa, con aplicación de la prueba t Student Pareado, considerando un nivel de significación del 95% y valores p < 0,05 como significativos. Resultados: Aumento del conocimiento teórico tras la intervención educativa, con un aumento de la puntuación media de los técnicos de enfermería de 5,30 (DP = 1,49) para 9,10 (DP = 1,79) y dos enfermeros de 11,83 (DP = 2,12) para 20,67 (DP = 2,46). Conclusión: Se espera que este conocimiento teórico sobre la prevención de complicaciones se haga efectivo en la práctica asistencial, mejorando así las prácticas de mantenimiento y, en consecuencia, reduciendo la retirada prematura del catéter.

RESUMO Comportamentos de risco na adolescência impactam a saúde de curto e longo prazo. A análise de dados de saúde dos países do Mercado Comum do Sul (Mercosul) pode fortalecer a vigilância e apoiar políticas públicas. Objetivou-se comparar as prevalências de indicadores em saúde de adolescentes nos países do Mercosul. Estudo descritivo, com dados do ‘Global School-based Student Health Survey’ na Argentina (2018), no Paraguai (2017) e no Uruguai (2019), e da ‘Pesquisa Nacional de Saúde do Escolar’ no Brasil (2015 e 2019). Analisaram-se as prevalências e os intervalos de confiança de 95% de indicadores para a população total de adolescentes e segundo o gênero. A experimentação do álcool antes dos 14 anos foi maior na Argentina enquanto a embriaguez foi maior no Brasil. O consumo atual de cigarro e o uso de qualquer produto do tabaco foram mais elevados na Argentina. A prática regular de atividade física foi menor no Brasil, já o comportamento sedentário foi maior no Uruguai. O Brasil teve o menor uso de preservativo na última relação sexual. Houve diferenças dos comportamentos de risco para saúde entre os adolescentes dos países estudados. Os resultados podem auxiliar entidades governamentais desses países a promoverem intercâmbio de boas práticas.

ABSTRACT Risk behaviours in adolescence have a short- and long-term impact on health. Analysing health data from the Southern Common Market (Mercosur) countries can strengthen surveillance and support public policies. To compare the prevalence of health indicators among adolescents in Mercosur countries. A descriptive study was conducted using data from the Global School-based Student Health Survey in Argentina (2018), Paraguay (2017), and Uruguay (2019), as well as from the National Survey of School Health in Brazil (2015 and 2019). Prevalence and 95% confidence intervals of indicators were analysed for the total adolescent population and by gender. Alcohol experimentation before the age of 14 was higher in Argentina, while drunkenness was higher in Brazil. Current cigarette smoking and any tobacco product use were higher in Argentina. Regular physical activity was lower in Brazil. Sedentary behaviour was higher in Uruguay. Brazil had the lowest condom use at last sexual intercourse. There were differences in health risk behaviours among adolescents in the studied countries. These results can assist governmental entities in these countries in promoting the exchange of best practices.

RESUMO Comportamentos de risco na adolescência impactam a saúde de curto e longo prazo. A análise de dados de saúde dos países do Mercado Comum do Sul (Mercosul) pode fortalecer a vigilância e apoiar políticas públicas. Objetivou-se comparar as prevalências de indicadores em saúde de adolescentes nos países do Mercosul. Estudo descritivo, com dados do ‘Global School-based Student Health Survey’ na Argentina (2018), no Paraguai (2017) e no Uruguai (2019), e da ‘Pesquisa Nacional de Saúde do Escolar’ no Brasil (2015 e 2019). Analisaram-se as prevalências e os intervalos de confiança de 95% de indicadores para a população total de adolescentes e segundo o gênero. A experimentação do álcool antes dos 14 anos foi maior na Argentina enquanto a embriaguez foi maior no Brasil. O consumo atual de cigarro e o uso de qualquer produto do tabaco foram mais elevados na Argentina. A prática regular de atividade física foi menor no Brasil, já o comportamento sedentário foi maior no Uruguai. O Brasil teve o menor uso de preservativo na última relação sexual. Houve diferenças dos comportamentos de risco para saúde entre os adolescentes dos países estudados. Os resultados podem auxiliar entidades governamentais desses países a promoverem intercâmbio de boas práticas. prazo Mercosul (Mercosul públicas Objetivouse Objetivou se descritivo Global Schoolbased School based Survey 2018, 2018 , (2018) 2017 (2017 2019, 2019 (2019) Pesquisa Escolar 2015 (201 2019. . 2019) Analisaramse Analisaram 95 gênero 1 sexual estudados práticas 201 (2018 (2019 (20 9 20 (2 2 (

ABSTRACT Risk behaviours in adolescence have a short- and long-term impact on health. Analysing health data from the Southern Common Market (Mercosur) countries can strengthen surveillance and support public policies. To compare the prevalence of health indicators among adolescents in Mercosur countries. A descriptive study was conducted using data from the Global School-based Student Health Survey in Argentina (2018), Paraguay (2017), and Uruguay (2019), as well as from the National Survey of School Health in Brazil (2015 and 2019). Prevalence and 95% confidence intervals of indicators were analysed for the total adolescent population and by gender. Alcohol experimentation before the age of 14 was higher in Argentina, while drunkenness was higher in Brazil. Current cigarette smoking and any tobacco product use were higher in Argentina. Regular physical activity was lower in Brazil. Sedentary behaviour was higher in Uruguay. Brazil had the lowest condom use at last sexual intercourse. There were differences in health risk behaviours among adolescents in the studied countries. These results can assist governmental entities in these countries in promoting the exchange of best practices. short longterm long term (Mercosur policies Schoolbased based 2018, 2018 , (2018) 2017, 2017 (2017) 2019, 2019 (2019) 2015 (201 2019. . 2019) 95 gender 1 intercourse practices 201 (2018 (2017 (2019 (20 9 20 (2 2 (

Abstract Objective: This study evaluates the association between fiber intake and obesity in Brazilian adolescents, according to sex and having meals with parents/guardians. Methods: We used data from the Study on Cardiovascular Risks in Adolescents (ERICA) (12-17 years), a cross-sectional study conducted between 2013 and 2014 in all cities with more than 100,000 inhabitants. Obesity was classified based on World Health Organization criteria for BMI. Fiber intake was obtained from a 24-hour dietary recall, and the following values were considered adequate: for males, ≥25g/day (aged 9-13 years) and ≥31g/day (aged 14-17 years); for females, ≥22g/day (aged 9-13 years) and ≥25g/day (aged 14-17 years). The categories for lunch and dinner with parents/guardians were “never/rarely/sometimes” versus “every day/almost every day”. Poisson regression models were used to examine the associations between obesity and fiber intake adjusted for covariates and stratified by sex and meals. Results: 69,627 adolescents were evaluated, 50.2% male and mean age 14.4 years (SD=1,6). A lower prevalence of obesity was observed in adolescents with adequate fiber intake who had lunch “every day/almost every day” (females: PR=0.51; 95%CI: 0.36-0.72; males: PR=0.59; 95%CI: 0.42-0.82) and dinner with their parents/guardians (females: PR=0.48; 95%CI: 0.35-0.65; males: PR=0.58; 95%CI: 0.42-0.78). Conclusion: Adolescents who frequently had meals with their parents/guardians and reported adequate fiber consumption had a lower prevalence of obesity.

Resumen Objetivo: Este estudio tiene como objetivo evaluar la asociación entre el consumo de fibra y la obesidad en adolescentes brasileños, según el sexo y la frecuencia de las comidas con padres/tutores. Métodos: Se utilizaron datos del Estudio de Riesgos Cardiovasculares en Adolescentes (ERICA) (12-17 años), un estudio transversal realizado entre 2013 y 2014 en todas las ciudades con más de 100.000 habitantes. La obesidad se clasificó según los criterios de IMC de la Organización Mundial de la Salud. La ingesta de fibra se obtuvo a partir de un recordatorio dietético de 24 horas, y se consideraron valores adecuados los siguientes: para varones de 9 a 13 años, ≥25 g/día y de 14 a 17 años, ≥31 g/día; para mujeres de 9 a 13 años, ≥22 g/día y de 14 a 17 años, ≥25 g/día. Las categorías para el almuerzo y la cena con padres/tutores fueron: “nunca/rara vez/a veces” vs. “todos los días/casi todos los días”. Se utilizaron modelos de regresión de Poisson para examinar las asociaciones entre la obesidad y la ingesta de fibra, ajustadas por covariables y estratificadas por sexo y comidas. Resultados: Se evaluaron 69.627 adolescentes, 50,2% varones, con una edad media de 14,4 años (DE=1,6). Se observó una menor prevalencia de obesidad en los adolescentes con una ingesta adecuada de fibra y que almorzaban “todos los días/casi todos los días” (mujeres: PR=0,51; IC95%: 0,36-0,72; varones: PR=0,59; IC95%: 0,42-0,82) y cenaban con sus padres/tutores (mujeres: PR=0,48; IC95%: 0,35-0,65; varones: PR=0,58; IC95%: 0,42-0,78). Conclusión: Los adolescentes que comían frecuentemente con sus padres/tutores y reportaban un consumo adecuado de fibra tenían una menor prevalencia de obesidad.

Resumo Objetivou-se analisar a percepção de estudantes e egressos sobre a utilização da Aprendizagem Baseada em Problemas (ABP) na formação do enfermeiro. Trata-se de um estudo qualitativo que utiliza a modalidade compreensiva e interpretativa proposta pela Hermenêutica-Dialética. Realizaram-se quatro grupos focais com a participação de 17 estudantes e 16 egressos de uma instituição de ensino superior que aplica a ABP na formação de enfermeiros. A análise dos resultados permitiu a definição de cinco categorias temáticas: dificuldade de adaptação em relação ao método; conquista de autonomia sobre o próprio aprendizado; incentivo ao desenvolvimento do raciocínio clínico; aprimoramento da comunicação e das relações interpessoais e integração entre teoria e prática. Evidencia-se que a utilização da ABP favorece a aproximação com as proposições das diretrizes curriculares para a formação do enfermeiro por meio do desenvolvimento de habilidades e competências como autonomia, comunicação, relações interpessoais e raciocínio clínico mediante práticas integrais e contextualizadas. Entretanto, os estudantes enfrentam dificuldades com as mudanças observadas ao serem inseridos nela ABP, as quais são superadas no decorrer do processo de implementação. Objetivouse Objetivou se (ABP Tratase Trata HermenêuticaDialética. HermenêuticaDialética Hermenêutica Dialética. Dialética Hermenêutica-Dialética Realizaramse Realizaram 1 enfermeiros temáticas método aprendizado prática Evidenciase Evidencia contextualizadas Entretanto implementação

Abstract This study aimed to analyze students’ and graduates’ perceptions regarding the use of Problem-Based Learning (PBL) in nurse education. This is a qualitative study that employs the comprehensive and interpretative approach proposed by Dialectical Hermeneutics. Four focus groups were conducted with the participation of 17 students and 16 graduates from a higher education institution that implements PBL in nurse education. The analysis of results allowed for the identification of five thematic categories: difficulty in adapting to the method; attainment of autonomy in one’s own learning; encouragement of clinical reasoning development; enhancement of communication and interpersonal relationships; and integration between theory and practice. It is evident that the use of PBL promotes alignment with the propositions of curriculum guidelines for nurse education by fostering the development of skills and competencies such as autonomy, communication, interpersonal relationships, and clinical reasoning through comprehensive and contextualized practices. However, students encounter challenges with the changes observed when introduced to PBL, which are overcome during the implementation process. ProblemBased Problem Based (PBL Hermeneutics 1 categories method ones one s learning relationships practice practices However process

RESUMO Neste trabalho, destacam-se aprendizados com pesquisa realizada pelo Núcleo Ecologias e Encontros de Saberes para a Promoção Emancipatória da Saúde (Neepes) em parceria com o Centro de Integração na Serra da Misericórdia (CEM) e o Movimento dos Sem Teto da Bahia (MSTB), que atuam em territórios periféricos no Rio de Janeiro e em Salvador. A pesquisa buscou apoiar e sistematizar conhecimentos e práticas emancipatórias de promoção da saúde protagonizados por essas experiências, tendo por base quatro eixos temáticos transversais: alimentação, cuidado, moradia e proteção ambiental, além de comunicação. No artigo, enfocaram-se as reflexões coletivas em relação ao primeiro eixo temático, envolvendo estratégias para promover agroecologia e soberania alimentar, com experiências de produção, circulação e acesso a alimentos saudáveis. Com base nessas reflexões, visou-se contribuir com discussões sobre Territórios Sustentáveis e Saudáveis (TSS), especialmente pelos aprendizados possibilitados com a sistematização das experiências territoriais com base na noção de Promoção Emancipatória da Saúde, que aponta para importantes aportes nas dimensões de justiça ambiental e cognitiva. Com a sistematização dessas experiências, destaca-se sua capacidade de resistir, a partir de um movimento de reexistência de saberes tradicionais e comunitários em periferias urbanas, que apontam caminhos possíveis para a construção de TSS em periferias urbanas. trabalho destacamse destacam se Neepes (Neepes CEM (CEM MSTB, MSTB , (MSTB) Salvador transversais alimentação cuidado comunicação artigo enfocaramse enfocaram temático alimentar produção saudáveis visouse visou TSS, (TSS) cognitiva destacase destaca resistir urbanas (MSTB (TSS

ABSTRACT In this work, we highlight lessons learned from research carried out by the Nucleus Ecologies and Encounters of Knowledge for Emancipatory Health Promotion (NEEPES) in partnership with the Center of Integration in Serra da Misericórdia (CEM) and the Movement of Homeless People of Bahia (MSTB), in peripheral territories in Rio de Janeiro and Salvador. The research sought to support and systematize knowledge and emancipatory practices of health promotion carried out by these experiences, based on four transversal thematic axes: food, care, housing and environmental protection, in addition to communication. The article focused on collective reflections on the first thematic axis, involving strategies to promote agroecology and food sovereignty, with experiences of production, circulation, and access to healthy food. Based on these reflections, we aim to contribute to discussions regarding the idea of Sustainable and Healthy Territories (SHT), especially through the lessons learned from the systematization of territorial experiences based on the notion of Emancipatory Health Promotion, which points to important contributions from the dimensions of environmental and cognitive justice. The systematization of these experiences highlights a movement of re-existence of traditional and community knowledge, which points to possible paths for the construction of SHT in urban peripheries. work NEEPES (NEEPES CEM (CEM MSTB, MSTB , (MSTB) Salvador axes care protection communication axis sovereignty production circulation SHT, (SHT) justice reexistence re existence peripheries (MSTB (SHT

RESUMO: Este trabalho avaliou diferentes genótipos de arroz quanto a parâmetros físico-químicos e instrumentais de qualidade do grão e associou os dados à análise sensorial para subsidiar a criação de regras de classificação da qualidade culinária do arroz (textura), com base em parâmetros isolados ou combinados. A combinação do teor de amilose e temperatura de gelatinização foi capaz de predizer a qualidade do arroz. De acordo com o painel sensorial, a pegajosidade instrumental foi capaz de segregar arroz com baixo teor de amilose ou ceroso dos demais. Em relação às propriedades de pasta, o arroz que apresentou alta viscosidade final (310-480RVU), retrogradação (165-245RVU) e temperatura de pasta (78-88 °C) e baixos valores de quebra pasta (15-120RVU), associados a uma alta pegajosidade (> -5N) será desejável pelos consumidores brasileiros. As regras de classificação criadas por meio da relação entre os parâmetros físico-químicos e o perfil de textura avaliado pelo painel sensorial ajudarão a verificar o perfil culinário das amostras de arroz (por meio de um software livre), o que torna mais fácil prever a probabilidade de o arroz atender aos padrões de qualidade desejados. RESUMO físicoquímicos físico químicos textura, , (textura) combinados demais 310480RVU, 310480RVU RVU 310 480RVU (310-480RVU) 165245RVU 165 245RVU (165-245RVU 7888 78 88 (78-8 °C C 15120RVU, 15120RVU 15 120RVU (15-120RVU) > ( 5N N -5N brasileiros livre, livre livre) desejados (textura 31 (310-480RVU 16 788 7 8 (78- 1 (15-120RVU 3 (78 (7

ABSTRACT: This research evaluated different rice genotypes regarding physicochemical and instrumental parameters of grain quality and associated the data with sensory analysis to support the creation of rules for classification of the culinary quality of rice (texture), based on isolated or combined parameters. The combination of amylose content and gelatinization temperature was able to predict the rice quality. According to the sensorial panel, the instrumental stickiness was able to segregate rice with very low amylose content or waxy to the other ones. Regarding pasting properties, rice that presented high final viscosity (310-480 RVU), setback (165-245 RVU), and pasting temperature (78 - 88 °C), and low values for breakdown (15-120 RVU), associated with a high stickiness (>-5N) was desirable by the Brazilian consumers. The classification rules created through the relationship between the physicochemical parameters and the texture profile evaluated by the sensory panel will help to verify the culinary profile of the rice samples (through free software), which makes it easier to predict the probability of rice meeting the desired quality standards. ABSTRACT texture, , (texture) ones properties 310480 310 480 (310-48 RVU, RVU RVU) 165245 165 245 (165-24 78 (7 8 °C, C °C °C) 15120 15 120 (15-12 >5N 5N N > (>-5N consumers software, software software) standards (texture 31048 31 48 (310-4 16524 16 24 (165-2 7 ( 1512 1 12 (15-1 3104 3 4 (310- 1652 2 (165- 151 (15- (310 (165 (15 (31 (16 (1 (3

Resumo Introdução: A doença renal crônica costuma ser assintomática e seu diagnóstico depende da realização de exames laboratoriais, com destaque para a creatinina sérica e pesquisa de proteinúria. Objetivo: Avaliar em uma amostra da população brasileira o conhecimento sobre o papel da creatinina sérica como marcador de função renal. Método: Estudo observacional transversal realizado na cidade de São Paulo (SP, Brasil), em que foi entrevistada uma população adulta aleatória. Resultados: Foram entrevistados 1138 indivíduos, com idade mediana de 36 anos (27–52); 55,1% do sexo feminino. Com relação ao marcador “creatinina”, 40,6% afirmaram que nunca realizaram tal dosagem. Quando questionados quanto ao conhecimento sobre a utilidade desse exame, somente 19,6% sabiam a sua função. As outras respostas foram “não sei” (71,6%), avaliar o funcionamento do coração (0,9%) e fígado (7,8%). Dos que afirmaram já terem realizado o exame de creatinina, somente 29,4% acertaram a função da creatinina. Ao dividir os grupos em “sabe” e “não sabe” a função da creatinina, percebeu-se diferença estatisticamente significante (p < 0,05) em relação ao grau de escolaridade, sexo feminino, ser aluno/trabalhador da saúde, ter dosado creatinina alguma vez, conhecer alguém com doença renal e maior idade. Na análise multivariada, a principal variável relacionada com conhecer a função da creatinina foi ter realizado o exame anteriormente (OR 5,16; IC 95% 3,16–8,43, p < 0,001). Conclusão: Há grande desconhecimento sobre a creatinina e seu uso em check-ups. Os resultados indicam que é necessário maior esforço por parte dos profissionais de saúde para divulgar o papel da creatinina sérica. Introdução laboratoriais proteinúria Objetivo Método SP, SP (SP Brasil, Brasil , Brasil) aleatória Resultados 113 indivíduos 3 27–52 2752 27 52 (27–52) 551 55 1 55,1 feminino “creatinina” 406 40 6 40,6 dosagem 196 19 19,6 não sei 71,6%, 716 71,6% 71 (71,6%) 0,9% 09 0 9 (0,9% 7,8%. 78 7,8% . 7 8 (7,8%) 294 29 4 29,4 sabe “sabe percebeuse percebeu se 0,05 005 05 escolaridade alunotrabalhador aluno trabalhador vez multivariada OR 5,16 516 5 16 95 316843 43 3,16–8,43 0,001. 0001 0,001 001 0,001) Conclusão checkups. checkups check ups. ups check-ups 11 27–5 275 2 (27–52 55, “creatinina 40, 19, 71,6 (71,6% 0,9 (0,9 7,8 (7,8% 29, 0,0 00 5,1 51 31684 3,16–8,4 000 0,00 27– (27–5 71, (71,6 0, (0, 7, (7,8 5, 3168 3,16–8, (27– (71, (0 (7, 316 3,16–8 (27 (71 ( (7 31 3,16– (2 3,16 3,1 3,

Abstract Introduction: Chronic kidney disease is usually asymptomatic, and its diagnosis depends on laboratory tests, with emphasis on serum creatinine and proteinuria. Objective: To assess knowledge on the role of serum creatinine as a biomarker of kidney function in a sample of the Brazilian population. Method: Cross-sectional observational study conducted in São Paulo (SP, Brazil), in which a random adult population was interviewed. Results: A total of 1138 subjects were interviewed, with a median age of 36 years old (27–52); 55.1% were female. Regarding the “creatinine” biomarker, 40.6% stated they had never performed such a test. When asked about their knowledge on the usefulness of this exam, only 19.6% knew its function. The other responses were “I don’t know” (71.6%), evaluating heart function (0.9%) and liver function (7.8%). Of those who reported they had already taken a creatinine test, only 29.4% correctly identified the role of creatinine. When dividing the groups into “knows” and “does not know” the function of creatinine, a statistically significant difference (p < 0.05) was observed regarding level of education, female sex, being a healthcare student/worker, having ever measured creatinine, knowing someone with kidney disease and older age. In the multivariate analysis, the main variable related to knowing the creatinine role was having previously taken the test (OR 5.16; 95% CI 3.16–8.43, p < 0.001). Conclusion: There is a significant lack of knowledge about creatinine and its use in checkups. The results indicate that greater efforts are needed from healthcare professionals to raise awareness on the role of serum creatinine. Introduction asymptomatic tests proteinuria Objective Method Crosssectional Cross sectional SP, SP (SP Brazil, Brazil , Brazil) interviewed Results 113 3 27–52 2752 27 52 (27–52) 551 55 1 55.1 “creatinine 406 40 6 40.6 exam 196 19 19.6 I dont don t know 71.6%, 716 71.6% 71 (71.6%) 0.9% 09 0 9 (0.9% 7.8%. 78 7.8% . 7 8 (7.8%) 294 29 4 29.4 knows “knows does 0.05 005 05 education sex studentworker student worker student/worker analysis OR 5.16 516 5 16 95 316843 43 3.16–8.43 0.001. 0001 0.001 001 0.001) Conclusion checkups 11 27–5 275 2 (27–52 55. 40. 19. 71.6 (71.6% 0.9 (0.9 7.8 (7.8% 29. 0.0 00 5.1 51 31684 3.16–8.4 000 0.00 27– (27–5 71. (71.6 0. (0. 7. (7.8 5. 3168 3.16–8. (27– (71. (0 (7. 316 3.16–8 (27 (71 ( (7 31 3.16– (2 3.16 3.1 3.

Resumo As questões da linguagem neutra e da ideologia de gênero ganharam destaque no ano de 2021 em Santa Catarina a partir da publicação do decreto 1.329/2021 que, dentre outras questões, veda expressamente as instituições de ensino e bancas examinadoras de seleção de concursos públicos a utilização de novas formas de flexão de gênero, especialmente na linguagem escrita, uma vez que, segundo o decreto, o aumento no número de palavras da língua portuguesa é contrário às regras gramaticais consolidadas. Neste contexto, o presente artigo visa estudar, sob uma perspectiva feminista, o movimento de supressão do debate sobre flexão de gênero e a articulação de discursos como a “ideologia de gênero” e “defesa da língua portuguesa” em Santa Catarina, considerando as tensões produzidas no campo da política e do direito. Trata-se de um estudo de abordagem qualitativa, sob método indutivo, com técnicas de pesquisa monográfica, teórica e documental, em que se pretende responder ao problema: de que forma se articularam posicionamentos de “ideologia de gênero” e “defesa da língua portuguesa” na aprovação do decreto que suprime o debate emSanta Catarina? A partir dessa análise, que não gira em torno da qualidade da linguagem neutra em si, conclui-se que a atuação política e institucional que enfrenta o debate sobre a linguagem neutra no estado não possui caráter democrático ao tolher o debate público sobre tema referente à educação e à cidadania. 202 13292021 1 329 1.329/202 escrita consolidadas contexto estudar feminista defesa direito Tratase Trata qualitativa indutivo monográfica documental problema análise si concluise conclui cidadania 20 1329202 32 1.329/20 2 132920 3 1.329/2 13292 1.329/ 1329 1.329 132 1.32 13 1.3 1.

Abstract Neutral language (non-binary language) and gender ideology issues have been highlighted at the state of Santa Catarina after the decree 1.329/2021 which expressly prohibits educational institutions and axamination boards from using gender inflection, especially in written language form, wich, according the decree, would increase the number of p ortuguese words, against the grammatical rules of the language. In this context, this article aims to study, from a feminist perspective, the movement to encourage the debate on gender flexion and the articulation of discourses such as “gender ideology” and “defense of the Portuguese language” in Santa Catarina, considering the tensions in the field of politics and law. This qualitative approach, under an inductive method, use monographic, theoretical and documentary research techniques, in which it is intended to answer the problem: how was the articulation of “gender ideology” and “defense of the Portuguese language” guidelines in the approval of the decree that suppresses the debate in Santa Catarina? From this analysis, which does not revolve the quality of neutral language itself, it is concluded that the political and institutional action that faces the debate on neutral language in the state does not have a democratic character. nonbinary non binary 13292021 1 329 2021 1.329/202 inflection form wich words context study perspective defense law approach method monographic techniques problem analysis itself character 1329202 32 202 1.329/20 132920 3 20 1.329/2 13292 2 1.329/ 1329 1.329 132 1.32 13 1.3 1.

Resumo Este artigo analisa a oferta de vagas no curso noturno de Odontologia de uma universidade federal enquanto democratização da Educação Superior com justiça social. Relata pesquisa empírica com ingressantes e concluintes do diurno e noturno, realizada por meio de aplicação de questionário e consulta a microdados do Censo da Educação Superior. A análise envolveu distribuição de frequências e teste estatístico. O curso de Odontologia noturno recebe mais estudantes acima de 25 anos, primeiros da família a cursar graduação, com intervalo de três anos ou mais entre o fim do Ensino Médio e o ingresso no curso, trabalhadores e com renda familiar menor que os ingressantes do diurno. O curso noturno tem menor número de concluintes pretos e pardos e de egressos das escolas públicas do que os ingressados, o que denota a fragilidade destes grupos na permanência e conclusão da Educação Superior. A oferta de vagas noturnas de Odontologia em universidade federal contribui para a justiça social na Educação Superior, ainda que seja necessário avançar na redução das desigualdades sociais e educacionais. estatístico 2 graduação ingressados educacionais

Abstract This article analyzes the offer of enrollment in the evening program in Dentistry at a federal university as a tool for the democratization of Higher Education with social justice. It reports empirical research with freshmen and graduates of daytime and evening programs, using a questionnaire and consultation to microdata from the Higher Education Census in Brazil. The analysis involved frequency distribution and statistical test. The Dentistry evening program showed a different student profile than the daytime program: average age over 25 years; longer interval between high school and university admission; larger proportion of students who are the first in their families to reach Higher Education; and, mainly, more working students. The evening course has a smaller number of black and brown graduates and public school graduates than new entrants, which demonstrate the fragility of these groups in terms of permanence and completion of Higher Education. Therefore, a Dentistry evening program at a public university somehow contributes to social justice in Higher Education, even though it is still necessary to reduce social and educational inequalities. programs Brazil test 2 years admission mainly entrants Therefore inequalities

Resumen Este artículo analiza la oferta de cupos en el programa nocturno de Odontología en una universidad federal de Brasil como una política de democratización de la Educación Superior con justicia social. Se reporta una investigación empírica con estudiantes de primer año y egresados de pregrado en clases diurna y nocturna, a través de la aplicación de un cuestionario y consulta con microdatos del Censo de Educación Superior. El análisis involucró distribución de frecuencias y prueba estadística. La carrera de Odontología nocturna recibe más estudiantes mayores de 25 años, primeros de la familia en asistir a la Educación Superior, con un intervalo de tres años o más entre la finalización del bachillerato y el ingreso en pregrado, trabajadores y con menores ingresos familiares que los que ingresan en la misma carrera para curso diurno. El programa nocturno cuenta con un número menor de egresados negros, morenos y de escuelas públicas que los que ingresaron, lo que demuestra la fragilidad de estos grupos en la permanencia y culminación de la Educación Superior. La oferta de cupos nocturnos en Odontología en una universidad federal contribuye a la justicia social en la Educación Superior, si bien es necesario avanzar en la reducción de las desigualdades sociales y educativas. estadística 2 diurno negros ingresaron educativas

Abstract To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease. Twenty years of real-life experience has demonstrated that hydroxyurea reduces pain attacks, vaso-occlusive events, including acute chest syndrome, the number and duration of hospitalizations and the need for transfusion. The therapeutic success of hydroxyurea is directly linked to access to the drug, the dose used and adherence to treatment which, in part, is correlated to the availability of hydroxyurea. This consensus aims to reduce the number of mandatory exams needed to access the drug, prioritizing the requesting physician's report, without affecting patient safety. date disease reallife real life attacks vasoocclusive vaso occlusive events syndrome transfusion which part physicians physician s report safety

Abstract Background: Real-world, primary data on the treatment of psoriasis are scarce, especially concerning the role of soluble biomarkers as outcome predictors. Objective: The authors evaluated the utility of Th1/Th17 serum cytokines along with clinical characteristics as predictors of drug survival in the treatment of psoriasis. Methods: The authors consecutively included participants with moderate to severe psoriasis who were followed up for 6 years. Baseline interferon-α, tumor necrosis factor-α, and inter-leukin (IL)-2, IL-4, IL-6, IL-10, and IL-17A were measured using a cytometric bead array; clinical data were assessed. The authors calculated hazard ratios (HRs) for drug survival using a Cox proportional hazards model. Results: The authors included 262 patients, most of whom used systemic immunosuppressants or biologics. In the multivariate model, poor quality of life measured by the Dermatology Life Quality Index (HR = 1.04; 95% CI 1.01–1.07; p = 0.012) and elevated baseline IL-6 (HR = 1.99; 95% CI 1.29–3.08; p = 0.002) were associated with treatment interruption. Study limitations: The main limitation of any cohort study is the presence of confounders that could not be detected in clinical evaluation. Conclusions: Poor quality of life and elevated baseline serum IL-6 level predicted treatment interruption in patients with moderate to severe psoriasis. Although IL-6 is not the most important mediator of the inflammatory pathway in the skin environment, it is an interesting biomarker candidate for predicting psoriasis treatment response. Background Realworld, Realworld Real world, world Real-world scarce Objective Th1Th17 ThTh Th1 Th17 Th Th1/Th1 Methods years interferonα, interferonα interferon α, α interferon-α factorα, factorα factor factor-α interleukin inter leukin IL2, IL2 IL 2, 2 (IL)-2 IL4, IL4 4, 4 IL-4 IL6, IL6 6, IL10, IL10 10, 10 IL-10 IL17A ILA 17A A array assessed HRs (HRs model Results 26 biologics HR 1.04 104 1 04 95 1.01–1.07 101107 01 07 0.012 0012 0 012 IL- 1.99 199 99 1.29–3.08 129308 29 3 08 0.002 0002 002 limitations evaluation Conclusions environment response Th1Th1 Th1/Th (IL)- IL1 IL-1 1.0 9 1.01–1.0 10110 0.01 001 1.9 19 1.29–3.0 12930 0.00 000 00 Th1Th (IL) 1. 1.01–1. 1011 0.0 1.29–3. 1293 (IL 1.01–1 101 0. 1.29–3 129 1.01– 1.29– 12 1.01 1.29 1.2

Abstract Background: Only a fraction of patients with cutaneous lupus erythematosus (CLE) will eventually progress toward systemic disease (SLE). Objective: To find inflammatory biomarkers which could predict the progression of cutaneous lupus erythematosus (CLE) into systemic lupus erythematosus (SLE) using immunohistochemical (IHC) assays. Methods: Immunohistochemical markers for cytotoxic, inflammatory, and anti-inflammatory responses and morphometric methods were applied to routine paraffin sections of skin biopsies, taken from lesions of 59 patients with discoid lupus, subacute lupus, and lupus tumidus. For the diagnosis of SLE, patients were classified by both the American College of Rheumatology (ACR-82) and the Systemic Lupus International Collaborating Clinics (SLICC-12) systems. Results: Skin samples from CLE/SLE +patients presented higher expression of IL-1β (ARC-82: p = 0.024; SLICC-12: p = 0.0143) and a significantly higher number of cells marked with granzyme B and perforin (ARC: p = 0.0097; SLICC-12: p = 0.0148). Biopsies from CLE/SLE- individuals had higher expression of IL-17 (ARC-82: p = 0.0003; SLICC-12: p = 0.0351) and presented a positive correlation between the density of granzyme A+and FoxP3+ cells (ARC-82: p = 0.0257; SLICC-12: p = 0.0285) and CD8+ cells (ARC-82: p = 0.0075; SLICC-12: p = 0.0102), as well as between granulysin-positive and CD8+ cells (ARC-82: p = 0.0024; SLICC-12: p = 0.0116). Study limitations: Patients were evaluated at a specific point in their evolution and according to the presence or not of systemic disease. The authors cannot predict how many more, from each group, would have evolved towards SLE in the following years. Conclusions: In this cohort, immunohistochemical findings suggested that patients with a tendency to systemic disease will show strong reactivity for IL-1β, while those with purely cutaneous involvement will tend to express IL-17 more intensely. Background CLE (CLE SLE. . Objective (SLE IHC (IHC assays Methods cytotoxic antiinflammatory anti biopsies 5 tumidus ACR82 ACR 82 (ACR-82 SLICC12 SLICC 12 (SLICC-12 systems Results CLESLE IL1β ILβ IL 1β β ARC82 ARC (ARC-82 0.024 0024 0 024 SLICC-12 0.0143 00143 0143 (ARC 0.0097 00097 0097 0.0148. 00148 0.0148 0148 0.0148) IL17 17 IL-1 0.0003 00003 0003 0.0351 00351 0351 Aand A FoxP3 FoxP 0.0257 00257 0257 0.0285 00285 0285 CD8 CD 0.0075 00075 0075 0.0102, 00102 0.0102 , 0102 0.0102) granulysinpositive granulysin 0.0024 00024 0.0116. 00116 0.0116 0116 0.0116) limitations group years Conclusions cohort IL1β, 1β, intensely ACR8 8 (ACR-8 SLICC1 1 (SLICC-1 ARC8 (ARC-8 0.02 002 02 SLICC-1 0.014 0014 014 0.009 0009 009 IL1 IL- 0.000 0000 000 0.035 0035 035 0.025 0025 025 0.028 0028 028 0.007 0007 007 0010 0.010 010 0.002 0002 0011 0.011 011 (ACR- (SLICC- (ARC- 0.0 00 SLICC- 0.01 001 01 0.00 0.03 003 03 (ACR (SLICC 0.

Abstract Aim: Polymorphisms in the COMT gene can alter enzymatic functions, raising levels of endogenous catecholamines, which stimulates beta-adrenergic receptors related to pain. This study aimed to evaluate whether a polymorphism in the COMT gene (rs4818) is associated with dental pain in children. Methodology: A cross-sectional study was conducted with a representative sample of 731 pairs of children and parents randomly selected from a population-based sample of eight-year-old children. Reports of dental pain was evaluated using a question directed at the parents and self-reported pain using the Faces Pain Scale – Revised. Dental caries experience was determined using the Decayed, Missing, and Filled Teeth (DMFT) index. For genetic analysis, DNA was obtained from oral mucosa epithelial cells of 352 children randomly selected from the initial sample. Results: Children with the CC genotype had higher odds of reporting moderate to intense pain than those with the GG genotype (OR=3.60; 95% CI=0.80–16.20; p=0.03). These same children had greater odds of parental reports of pain (OR=1.93; 95% CI=0.91-4.08; p=0.02). Moreover, lower schooling of parents/guardians and caries experience in the primary dentition were significantly associated with greater odds of a parental report of dental pain (OR=2.06; 95% CI=1.47–2.91; p<0.001; OR=6.26; 95% CI=4.46–8.78; p<0.001). Conclusions: The rs4818 polymorphism of the COMT gene is associated with dental pain. Children with the C allele are more likely to report higher levels of pain. Clinical Relevance: Even though the experience of pain is subjective and multifactorial, this study raises the hypothesis that there is a genetic predisposition to dental pain that should be considered in clinical practice. Aim functions catecholamines betaadrenergic beta adrenergic rs (rs4818 Methodology crosssectional cross sectional 73 populationbased population based eightyearold eight year old selfreported self reported Revised Decayed Missing DMFT (DMFT index analysis 35 Results OR=3.60 OR360 OR 3 60 (OR=3.60 95 CI=0.80–16.20 CI0801620 CI 0 80 16 20 p=0.03. p003 p p=0.03 . 03 p=0.03) OR=1.93 OR193 1 93 (OR=1.93 CI=0.914.08 CI091408 CI=0.91 4.08 91 4 08 CI=0.91-4.08 p=0.02. p002 p=0.02 02 p=0.02) Moreover parentsguardians guardians OR=2.06 OR206 2 06 (OR=2.06 CI=1.47–2.91 CI147291 47 p<0.001 p0001 001 OR=6.26 OR626 6 26 CI=4.46–8.78 CI446878 46 8 78 p<0.001. p<0.001) Conclusions rs481 Relevance multifactorial practice (rs481 7 OR=3.6 OR36 (OR=3.6 9 CI=0.80–16.2 CI080162 p00 p=0.0 OR=1.9 OR19 (OR=1.9 914 CI=0.914.0 CI09140 CI091 CI=0.9 408 4.0 CI=0.91-4.0 OR=2.0 OR20 (OR=2.0 CI=1.47–2.9 CI14729 p<0.00 p000 00 OR=6.2 OR62 CI=4.46–8.7 CI44687 rs48 (rs48 OR=3. OR3 (OR=3. CI=0.80–16. CI08016 p0 p=0. OR=1. OR1 (OR=1. CI=0.914. CI0914 CI09 CI=0. 40 4. CI=0.91-4. OR=2. OR2 (OR=2. CI=1.47–2. CI1472 p<0.0 OR=6. OR6 CI=4.46–8. CI4468 rs4 (rs4 OR=3 (OR=3 CI=0.80–16 CI0801 p=0 OR=1 (OR=1 CI=0.914 CI0 CI=0 CI=0.91-4 OR=2 (OR=2 CI=1.47–2 CI147 p<0. OR=6 CI=4.46–8 CI446 (rs OR= (OR= CI=0.80–1 CI080 p= CI= CI=0.91- CI=1.47– CI14 p<0 CI=4.46– CI44 (OR CI=0.80– CI08 CI=1.47 CI1 p< CI=4.46 CI4 CI=0.80 CI=1.4 CI=4.4 CI=0.8 CI=1. CI=4. CI=1 CI=4