Abstract This study aimed to analyze students’ and graduates’ perceptions regarding the use of Problem-Based Learning (PBL) in nurse education. This is a qualitative study that employs the comprehensive and interpretative approach proposed by Dialectical Hermeneutics. Four focus groups were conducted with the participation of 17 students and 16 graduates from a higher education institution that implements PBL in nurse education. The analysis of results allowed for the identification of five thematic categories: difficulty in adapting to the method; attainment of autonomy in one’s own learning; encouragement of clinical reasoning development; enhancement of communication and interpersonal relationships; and integration between theory and practice. It is evident that the use of PBL promotes alignment with the propositions of curriculum guidelines for nurse education by fostering the development of skills and competencies such as autonomy, communication, interpersonal relationships, and clinical reasoning through comprehensive and contextualized practices. However, students encounter challenges with the changes observed when introduced to PBL, which are overcome during the implementation process. ProblemBased Problem Based (PBL Hermeneutics 1 categories method ones one s learning relationships practice practices However process

Resumo Objetivou-se analisar a percepção de estudantes e egressos sobre a utilização da Aprendizagem Baseada em Problemas (ABP) na formação do enfermeiro. Trata-se de um estudo qualitativo que utiliza a modalidade compreensiva e interpretativa proposta pela Hermenêutica-Dialética. Realizaram-se quatro grupos focais com a participação de 17 estudantes e 16 egressos de uma instituição de ensino superior que aplica a ABP na formação de enfermeiros. A análise dos resultados permitiu a definição de cinco categorias temáticas: dificuldade de adaptação em relação ao método; conquista de autonomia sobre o próprio aprendizado; incentivo ao desenvolvimento do raciocínio clínico; aprimoramento da comunicação e das relações interpessoais e integração entre teoria e prática. Evidencia-se que a utilização da ABP favorece a aproximação com as proposições das diretrizes curriculares para a formação do enfermeiro por meio do desenvolvimento de habilidades e competências como autonomia, comunicação, relações interpessoais e raciocínio clínico mediante práticas integrais e contextualizadas. Entretanto, os estudantes enfrentam dificuldades com as mudanças observadas ao serem inseridos nela ABP, as quais são superadas no decorrer do processo de implementação. Objetivouse Objetivou se (ABP Tratase Trata HermenêuticaDialética. HermenêuticaDialética Hermenêutica Dialética. Dialética Hermenêutica-Dialética Realizaramse Realizaram 1 enfermeiros temáticas método aprendizado prática Evidenciase Evidencia contextualizadas Entretanto implementação

ABSTRACT: This research evaluated different rice genotypes regarding physicochemical and instrumental parameters of grain quality and associated the data with sensory analysis to support the creation of rules for classification of the culinary quality of rice (texture), based on isolated or combined parameters. The combination of amylose content and gelatinization temperature was able to predict the rice quality. According to the sensorial panel, the instrumental stickiness was able to segregate rice with very low amylose content or waxy to the other ones. Regarding pasting properties, rice that presented high final viscosity (310-480 RVU), setback (165-245 RVU), and pasting temperature (78 - 88 °C), and low values for breakdown (15-120 RVU), associated with a high stickiness (>-5N) was desirable by the Brazilian consumers. The classification rules created through the relationship between the physicochemical parameters and the texture profile evaluated by the sensory panel will help to verify the culinary profile of the rice samples (through free software), which makes it easier to predict the probability of rice meeting the desired quality standards. ABSTRACT texture, , (texture) ones properties 310480 310 480 (310-48 RVU, RVU RVU) 165245 165 245 (165-24 78 (7 8 °C, C °C °C) 15120 15 120 (15-12 >5N 5N N > (>-5N consumers software, software software) standards (texture 31048 31 48 (310-4 16524 16 24 (165-2 7 ( 1512 1 12 (15-1 3104 3 4 (310- 1652 2 (165- 151 (15- (310 (165 (15 (31 (16 (1 (3

RESUMO: Este trabalho avaliou diferentes genótipos de arroz quanto a parâmetros físico-químicos e instrumentais de qualidade do grão e associou os dados à análise sensorial para subsidiar a criação de regras de classificação da qualidade culinária do arroz (textura), com base em parâmetros isolados ou combinados. A combinação do teor de amilose e temperatura de gelatinização foi capaz de predizer a qualidade do arroz. De acordo com o painel sensorial, a pegajosidade instrumental foi capaz de segregar arroz com baixo teor de amilose ou ceroso dos demais. Em relação às propriedades de pasta, o arroz que apresentou alta viscosidade final (310-480RVU), retrogradação (165-245RVU) e temperatura de pasta (78-88 °C) e baixos valores de quebra pasta (15-120RVU), associados a uma alta pegajosidade (> -5N) será desejável pelos consumidores brasileiros. As regras de classificação criadas por meio da relação entre os parâmetros físico-químicos e o perfil de textura avaliado pelo painel sensorial ajudarão a verificar o perfil culinário das amostras de arroz (por meio de um software livre), o que torna mais fácil prever a probabilidade de o arroz atender aos padrões de qualidade desejados. RESUMO físicoquímicos físico químicos textura, , (textura) combinados demais 310480RVU, 310480RVU RVU 310 480RVU (310-480RVU) 165245RVU 165 245RVU (165-245RVU 7888 78 88 (78-8 °C C 15120RVU, 15120RVU 15 120RVU (15-120RVU) > ( 5N N -5N brasileiros livre, livre livre) desejados (textura 31 (310-480RVU 16 788 7 8 (78- 1 (15-120RVU 3 (78 (7

Abstract Introduction: Chronic kidney disease is usually asymptomatic, and its diagnosis depends on laboratory tests, with emphasis on serum creatinine and proteinuria. Objective: To assess knowledge on the role of serum creatinine as a biomarker of kidney function in a sample of the Brazilian population. Method: Cross-sectional observational study conducted in São Paulo (SP, Brazil), in which a random adult population was interviewed. Results: A total of 1138 subjects were interviewed, with a median age of 36 years old (27–52); 55.1% were female. Regarding the “creatinine” biomarker, 40.6% stated they had never performed such a test. When asked about their knowledge on the usefulness of this exam, only 19.6% knew its function. The other responses were “I don’t know” (71.6%), evaluating heart function (0.9%) and liver function (7.8%). Of those who reported they had already taken a creatinine test, only 29.4% correctly identified the role of creatinine. When dividing the groups into “knows” and “does not know” the function of creatinine, a statistically significant difference (p < 0.05) was observed regarding level of education, female sex, being a healthcare student/worker, having ever measured creatinine, knowing someone with kidney disease and older age. In the multivariate analysis, the main variable related to knowing the creatinine role was having previously taken the test (OR 5.16; 95% CI 3.16–8.43, p < 0.001). Conclusion: There is a significant lack of knowledge about creatinine and its use in checkups. The results indicate that greater efforts are needed from healthcare professionals to raise awareness on the role of serum creatinine. Introduction asymptomatic tests proteinuria Objective Method Crosssectional Cross sectional SP, SP (SP Brazil, Brazil , Brazil) interviewed Results 113 3 27–52 2752 27 52 (27–52) 551 55 1 55.1 “creatinine 406 40 6 40.6 exam 196 19 19.6 I dont don t know 71.6%, 716 71.6% 71 (71.6%) 0.9% 09 0 9 (0.9% 7.8%. 78 7.8% . 7 8 (7.8%) 294 29 4 29.4 knows “knows does 0.05 005 05 education sex studentworker student worker student/worker analysis OR 5.16 516 5 16 95 316843 43 3.16–8.43 0.001. 0001 0.001 001 0.001) Conclusion checkups 11 27–5 275 2 (27–52 55. 40. 19. 71.6 (71.6% 0.9 (0.9 7.8 (7.8% 29. 0.0 00 5.1 51 31684 3.16–8.4 000 0.00 27– (27–5 71. (71.6 0. (0. 7. (7.8 5. 3168 3.16–8. (27– (71. (0 (7. 316 3.16–8 (27 (71 ( (7 31 3.16– (2 3.16 3.1 3.

Resumo Introdução: A doença renal crônica costuma ser assintomática e seu diagnóstico depende da realização de exames laboratoriais, com destaque para a creatinina sérica e pesquisa de proteinúria. Objetivo: Avaliar em uma amostra da população brasileira o conhecimento sobre o papel da creatinina sérica como marcador de função renal. Método: Estudo observacional transversal realizado na cidade de São Paulo (SP, Brasil), em que foi entrevistada uma população adulta aleatória. Resultados: Foram entrevistados 1138 indivíduos, com idade mediana de 36 anos (27–52); 55,1% do sexo feminino. Com relação ao marcador “creatinina”, 40,6% afirmaram que nunca realizaram tal dosagem. Quando questionados quanto ao conhecimento sobre a utilidade desse exame, somente 19,6% sabiam a sua função. As outras respostas foram “não sei” (71,6%), avaliar o funcionamento do coração (0,9%) e fígado (7,8%). Dos que afirmaram já terem realizado o exame de creatinina, somente 29,4% acertaram a função da creatinina. Ao dividir os grupos em “sabe” e “não sabe” a função da creatinina, percebeu-se diferença estatisticamente significante (p < 0,05) em relação ao grau de escolaridade, sexo feminino, ser aluno/trabalhador da saúde, ter dosado creatinina alguma vez, conhecer alguém com doença renal e maior idade. Na análise multivariada, a principal variável relacionada com conhecer a função da creatinina foi ter realizado o exame anteriormente (OR 5,16; IC 95% 3,16–8,43, p < 0,001). Conclusão: Há grande desconhecimento sobre a creatinina e seu uso em check-ups. Os resultados indicam que é necessário maior esforço por parte dos profissionais de saúde para divulgar o papel da creatinina sérica. Introdução laboratoriais proteinúria Objetivo Método SP, SP (SP Brasil, Brasil , Brasil) aleatória Resultados 113 indivíduos 3 27–52 2752 27 52 (27–52) 551 55 1 55,1 feminino “creatinina” 406 40 6 40,6 dosagem 196 19 19,6 não sei 71,6%, 716 71,6% 71 (71,6%) 0,9% 09 0 9 (0,9% 7,8%. 78 7,8% . 7 8 (7,8%) 294 29 4 29,4 sabe “sabe percebeuse percebeu se 0,05 005 05 escolaridade alunotrabalhador aluno trabalhador vez multivariada OR 5,16 516 5 16 95 316843 43 3,16–8,43 0,001. 0001 0,001 001 0,001) Conclusão checkups. checkups check ups. ups check-ups 11 27–5 275 2 (27–52 55, “creatinina 40, 19, 71,6 (71,6% 0,9 (0,9 7,8 (7,8% 29, 0,0 00 5,1 51 31684 3,16–8,4 000 0,00 27– (27–5 71, (71,6 0, (0, 7, (7,8 5, 3168 3,16–8, (27– (71, (0 (7, 316 3,16–8 (27 (71 ( (7 31 3,16– (2 3,16 3,1 3,

Resumen Este artículo analiza la oferta de cupos en el programa nocturno de Odontología en una universidad federal de Brasil como una política de democratización de la Educación Superior con justicia social. Se reporta una investigación empírica con estudiantes de primer año y egresados de pregrado en clases diurna y nocturna, a través de la aplicación de un cuestionario y consulta con microdatos del Censo de Educación Superior. El análisis involucró distribución de frecuencias y prueba estadística. La carrera de Odontología nocturna recibe más estudiantes mayores de 25 años, primeros de la familia en asistir a la Educación Superior, con un intervalo de tres años o más entre la finalización del bachillerato y el ingreso en pregrado, trabajadores y con menores ingresos familiares que los que ingresan en la misma carrera para curso diurno. El programa nocturno cuenta con un número menor de egresados negros, morenos y de escuelas públicas que los que ingresaron, lo que demuestra la fragilidad de estos grupos en la permanencia y culminación de la Educación Superior. La oferta de cupos nocturnos en Odontología en una universidad federal contribuye a la justicia social en la Educación Superior, si bien es necesario avanzar en la reducción de las desigualdades sociales y educativas. estadística 2 diurno negros ingresaron educativas

Abstract This article analyzes the offer of enrollment in the evening program in Dentistry at a federal university as a tool for the democratization of Higher Education with social justice. It reports empirical research with freshmen and graduates of daytime and evening programs, using a questionnaire and consultation to microdata from the Higher Education Census in Brazil. The analysis involved frequency distribution and statistical test. The Dentistry evening program showed a different student profile than the daytime program: average age over 25 years; longer interval between high school and university admission; larger proportion of students who are the first in their families to reach Higher Education; and, mainly, more working students. The evening course has a smaller number of black and brown graduates and public school graduates than new entrants, which demonstrate the fragility of these groups in terms of permanence and completion of Higher Education. Therefore, a Dentistry evening program at a public university somehow contributes to social justice in Higher Education, even though it is still necessary to reduce social and educational inequalities. programs Brazil test 2 years admission mainly entrants Therefore inequalities

Resumo Este artigo analisa a oferta de vagas no curso noturno de Odontologia de uma universidade federal enquanto democratização da Educação Superior com justiça social. Relata pesquisa empírica com ingressantes e concluintes do diurno e noturno, realizada por meio de aplicação de questionário e consulta a microdados do Censo da Educação Superior. A análise envolveu distribuição de frequências e teste estatístico. O curso de Odontologia noturno recebe mais estudantes acima de 25 anos, primeiros da família a cursar graduação, com intervalo de três anos ou mais entre o fim do Ensino Médio e o ingresso no curso, trabalhadores e com renda familiar menor que os ingressantes do diurno. O curso noturno tem menor número de concluintes pretos e pardos e de egressos das escolas públicas do que os ingressados, o que denota a fragilidade destes grupos na permanência e conclusão da Educação Superior. A oferta de vagas noturnas de Odontologia em universidade federal contribui para a justiça social na Educação Superior, ainda que seja necessário avançar na redução das desigualdades sociais e educacionais. estatístico 2 graduação ingressados educacionais

Abstract Neutral language (non-binary language) and gender ideology issues have been highlighted at the state of Santa Catarina after the decree 1.329/2021 which expressly prohibits educational institutions and axamination boards from using gender inflection, especially in written language form, wich, according the decree, would increase the number of p ortuguese words, against the grammatical rules of the language. In this context, this article aims to study, from a feminist perspective, the movement to encourage the debate on gender flexion and the articulation of discourses such as “gender ideology” and “defense of the Portuguese language” in Santa Catarina, considering the tensions in the field of politics and law. This qualitative approach, under an inductive method, use monographic, theoretical and documentary research techniques, in which it is intended to answer the problem: how was the articulation of “gender ideology” and “defense of the Portuguese language” guidelines in the approval of the decree that suppresses the debate in Santa Catarina? From this analysis, which does not revolve the quality of neutral language itself, it is concluded that the political and institutional action that faces the debate on neutral language in the state does not have a democratic character. nonbinary non binary 13292021 1 329 2021 1.329/202 inflection form wich words context study perspective defense law approach method monographic techniques problem analysis itself character 1329202 32 202 1.329/20 132920 3 20 1.329/2 13292 2 1.329/ 1329 1.329 132 1.32 13 1.3 1.

Resumo As questões da linguagem neutra e da ideologia de gênero ganharam destaque no ano de 2021 em Santa Catarina a partir da publicação do decreto 1.329/2021 que, dentre outras questões, veda expressamente as instituições de ensino e bancas examinadoras de seleção de concursos públicos a utilização de novas formas de flexão de gênero, especialmente na linguagem escrita, uma vez que, segundo o decreto, o aumento no número de palavras da língua portuguesa é contrário às regras gramaticais consolidadas. Neste contexto, o presente artigo visa estudar, sob uma perspectiva feminista, o movimento de supressão do debate sobre flexão de gênero e a articulação de discursos como a “ideologia de gênero” e “defesa da língua portuguesa” em Santa Catarina, considerando as tensões produzidas no campo da política e do direito. Trata-se de um estudo de abordagem qualitativa, sob método indutivo, com técnicas de pesquisa monográfica, teórica e documental, em que se pretende responder ao problema: de que forma se articularam posicionamentos de “ideologia de gênero” e “defesa da língua portuguesa” na aprovação do decreto que suprime o debate emSanta Catarina? A partir dessa análise, que não gira em torno da qualidade da linguagem neutra em si, conclui-se que a atuação política e institucional que enfrenta o debate sobre a linguagem neutra no estado não possui caráter democrático ao tolher o debate público sobre tema referente à educação e à cidadania. 202 13292021 1 329 1.329/202 escrita consolidadas contexto estudar feminista defesa direito Tratase Trata qualitativa indutivo monográfica documental problema análise si concluise conclui cidadania 20 1329202 32 1.329/20 2 132920 3 1.329/2 13292 1.329/ 1329 1.329 132 1.32 13 1.3 1.

Abstract To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease. Twenty years of real-life experience has demonstrated that hydroxyurea reduces pain attacks, vaso-occlusive events, including acute chest syndrome, the number and duration of hospitalizations and the need for transfusion. The therapeutic success of hydroxyurea is directly linked to access to the drug, the dose used and adherence to treatment which, in part, is correlated to the availability of hydroxyurea. This consensus aims to reduce the number of mandatory exams needed to access the drug, prioritizing the requesting physician's report, without affecting patient safety. date disease reallife real life attacks vasoocclusive vaso occlusive events syndrome transfusion which part physicians physician s report safety

Abstract Background: Real-world, primary data on the treatment of psoriasis are scarce, especially concerning the role of soluble biomarkers as outcome predictors. Objective: The authors evaluated the utility of Th1/Th17 serum cytokines along with clinical characteristics as predictors of drug survival in the treatment of psoriasis. Methods: The authors consecutively included participants with moderate to severe psoriasis who were followed up for 6 years. Baseline interferon-α, tumor necrosis factor-α, and inter-leukin (IL)-2, IL-4, IL-6, IL-10, and IL-17A were measured using a cytometric bead array; clinical data were assessed. The authors calculated hazard ratios (HRs) for drug survival using a Cox proportional hazards model. Results: The authors included 262 patients, most of whom used systemic immunosuppressants or biologics. In the multivariate model, poor quality of life measured by the Dermatology Life Quality Index (HR = 1.04; 95% CI 1.01–1.07; p = 0.012) and elevated baseline IL-6 (HR = 1.99; 95% CI 1.29–3.08; p = 0.002) were associated with treatment interruption. Study limitations: The main limitation of any cohort study is the presence of confounders that could not be detected in clinical evaluation. Conclusions: Poor quality of life and elevated baseline serum IL-6 level predicted treatment interruption in patients with moderate to severe psoriasis. Although IL-6 is not the most important mediator of the inflammatory pathway in the skin environment, it is an interesting biomarker candidate for predicting psoriasis treatment response. Background Realworld, Realworld Real world, world Real-world scarce Objective Th1Th17 ThTh Th1 Th17 Th Th1/Th1 Methods years interferonα, interferonα interferon α, α interferon-α factorα, factorα factor factor-α interleukin inter leukin IL2, IL2 IL 2, 2 (IL)-2 IL4, IL4 4, 4 IL-4 IL6, IL6 6, IL10, IL10 10, 10 IL-10 IL17A ILA 17A A array assessed HRs (HRs model Results 26 biologics HR 1.04 104 1 04 95 1.01–1.07 101107 01 07 0.012 0012 0 012 IL- 1.99 199 99 1.29–3.08 129308 29 3 08 0.002 0002 002 limitations evaluation Conclusions environment response Th1Th1 Th1/Th (IL)- IL1 IL-1 1.0 9 1.01–1.0 10110 0.01 001 1.9 19 1.29–3.0 12930 0.00 000 00 Th1Th (IL) 1. 1.01–1. 1011 0.0 1.29–3. 1293 (IL 1.01–1 101 0. 1.29–3 129 1.01– 1.29– 12 1.01 1.29 1.2

Abstract Background: Only a fraction of patients with cutaneous lupus erythematosus (CLE) will eventually progress toward systemic disease (SLE). Objective: To find inflammatory biomarkers which could predict the progression of cutaneous lupus erythematosus (CLE) into systemic lupus erythematosus (SLE) using immunohistochemical (IHC) assays. Methods: Immunohistochemical markers for cytotoxic, inflammatory, and anti-inflammatory responses and morphometric methods were applied to routine paraffin sections of skin biopsies, taken from lesions of 59 patients with discoid lupus, subacute lupus, and lupus tumidus. For the diagnosis of SLE, patients were classified by both the American College of Rheumatology (ACR-82) and the Systemic Lupus International Collaborating Clinics (SLICC-12) systems. Results: Skin samples from CLE/SLE +patients presented higher expression of IL-1β (ARC-82: p = 0.024; SLICC-12: p = 0.0143) and a significantly higher number of cells marked with granzyme B and perforin (ARC: p = 0.0097; SLICC-12: p = 0.0148). Biopsies from CLE/SLE- individuals had higher expression of IL-17 (ARC-82: p = 0.0003; SLICC-12: p = 0.0351) and presented a positive correlation between the density of granzyme A+and FoxP3+ cells (ARC-82: p = 0.0257; SLICC-12: p = 0.0285) and CD8+ cells (ARC-82: p = 0.0075; SLICC-12: p = 0.0102), as well as between granulysin-positive and CD8+ cells (ARC-82: p = 0.0024; SLICC-12: p = 0.0116). Study limitations: Patients were evaluated at a specific point in their evolution and according to the presence or not of systemic disease. The authors cannot predict how many more, from each group, would have evolved towards SLE in the following years. Conclusions: In this cohort, immunohistochemical findings suggested that patients with a tendency to systemic disease will show strong reactivity for IL-1β, while those with purely cutaneous involvement will tend to express IL-17 more intensely. Background CLE (CLE SLE. . Objective (SLE IHC (IHC assays Methods cytotoxic antiinflammatory anti biopsies 5 tumidus ACR82 ACR 82 (ACR-82 SLICC12 SLICC 12 (SLICC-12 systems Results CLESLE IL1β ILβ IL 1β β ARC82 ARC (ARC-82 0.024 0024 0 024 SLICC-12 0.0143 00143 0143 (ARC 0.0097 00097 0097 0.0148. 00148 0.0148 0148 0.0148) IL17 17 IL-1 0.0003 00003 0003 0.0351 00351 0351 Aand A FoxP3 FoxP 0.0257 00257 0257 0.0285 00285 0285 CD8 CD 0.0075 00075 0075 0.0102, 00102 0.0102 , 0102 0.0102) granulysinpositive granulysin 0.0024 00024 0.0116. 00116 0.0116 0116 0.0116) limitations group years Conclusions cohort IL1β, 1β, intensely ACR8 8 (ACR-8 SLICC1 1 (SLICC-1 ARC8 (ARC-8 0.02 002 02 SLICC-1 0.014 0014 014 0.009 0009 009 IL1 IL- 0.000 0000 000 0.035 0035 035 0.025 0025 025 0.028 0028 028 0.007 0007 007 0010 0.010 010 0.002 0002 0011 0.011 011 (ACR- (SLICC- (ARC- 0.0 00 SLICC- 0.01 001 01 0.00 0.03 003 03 (ACR (SLICC 0.

Abstract Introduction: Chronic kidney disease is usually asymptomatic, and its diagnosis depends on laboratory tests, with emphasis on serum creatinine and proteinuria. Objective: To assess knowledge on the role of serum creatinine as a biomarker of kidney function in a sample of the Brazilian population. Method: Cross-sectional observational study conducted in São Paulo (SP, Brazil), in which a random adult population was interviewed. Results: A total of 1138 subjects were interviewed, with a median age of 36 years old (27–52); 55.1% were female. Regarding the “creatinine” biomarker, 40.6% stated they had never performed such a test. When asked about their knowledge on the usefulness of this exam, only 19.6% knew its function. The other responses were “I don’t know” (71.6%), evaluating heart function (0.9%) and liver function (7.8%). Of those who reported they had already taken a creatinine test, only 29.4% correctly identified the role of creatinine. When dividing the groups into “knows” and “does not know” the function of creatinine, a statistically significant difference (p < 0.05) was observed regarding level of education, female sex, being a healthcare student/worker, having ever measured creatinine, knowing someone with kidney disease and older age. In the multivariate analysis, the main variable related to knowing the creatinine role was having previously taken the test (OR 5.16; 95% CI 3.16–8.43, p < 0.001). Conclusion: There is a significant lack of knowledge about creatinine and its use in checkups. The results indicate that greater efforts are needed from healthcare professionals to raise awareness on the role of serum creatinine.

Resumo Introdução: A doença renal crônica costuma ser assintomática e seu diagnóstico depende da realização de exames laboratoriais, com destaque para a creatinina sérica e pesquisa de proteinúria. Objetivo: Avaliar em uma amostra da população brasileira o conhecimento sobre o papel da creatinina sérica como marcador de função renal. Método: Estudo observacional transversal realizado na cidade de São Paulo (SP, Brasil), em que foi entrevistada uma população adulta aleatória. Resultados: Foram entrevistados 1138 indivíduos, com idade mediana de 36 anos (27–52); 55,1% do sexo feminino. Com relação ao marcador “creatinina”, 40,6% afirmaram que nunca realizaram tal dosagem. Quando questionados quanto ao conhecimento sobre a utilidade desse exame, somente 19,6% sabiam a sua função. As outras respostas foram “não sei” (71,6%), avaliar o funcionamento do coração (0,9%) e fígado (7,8%). Dos que afirmaram já terem realizado o exame de creatinina, somente 29,4% acertaram a função da creatinina. Ao dividir os grupos em “sabe” e “não sabe” a função da creatinina, percebeu-se diferença estatisticamente significante (p < 0,05) em relação ao grau de escolaridade, sexo feminino, ser aluno/trabalhador da saúde, ter dosado creatinina alguma vez, conhecer alguém com doença renal e maior idade. Na análise multivariada, a principal variável relacionada com conhecer a função da creatinina foi ter realizado o exame anteriormente (OR 5,16; IC 95% 3,16–8,43, p < 0,001). Conclusão: Há grande desconhecimento sobre a creatinina e seu uso em check-ups. Os resultados indicam que é necessário maior esforço por parte dos profissionais de saúde para divulgar o papel da creatinina sérica.

ABSTRACT: In this study, we analyzed the hypothesis that the combination of Nitrospirillum amazonense strain BR11145 with biological fertilizer prepared using Microgeo® and native microbiome from location of the product application results in morphological and nutritional gains for the initial development of sugarcane plants and soil chemistry. For this purpose, pre-sprouted sugarcane seedlings were grown in a greenhouse mesocosm experiment using soil amended with nitrogen/phosphorus/potassium fertilizer. The experimental treatments consisted of: 1) biological fertilizer with the addition of N. amazonense (100 mL ha-1), 2) biological fertilizer without the addition of N. amazonense, 3) inoculation with N. amazonense at a dose of 100 mL ha-1 with 2x108 viable cell mL-1, 4) inoculation with N. amazonense at a dose of 200 mL ha-1 with 2x108 viable cell mL-1, and 5) control, without the addition of biological fertilizer and N. amazonense. The biological fertilizer was applied at dose of 300 L ha-1, which was split at planting (200 L ha-1) and in the post-emergence phase (100 L ha-1). After 164 days of planting, it was detected an increase in leaf length +3, number of green leaves, leaf area and sulfur content in the leaves of sugarcane plants that received the biological fertilizer with the addition of N. amazonense. In conclusion, the combination of N. amazonense with biological fertilizer revealed positive effects through morphological and nutritional characteristics in sugarcane plants during their early stages of development when compared to plants grown only with the inoculation of N. amazonense, biological fertilizer or mineral fertilizers, with few notable positive effects on soil chemistry. ABSTRACT study BR BR1114 Microgeo chemistry purpose presprouted pre sprouted nitrogenphosphoruspotassium nitrogen phosphorus potassium 1 N (10 ha1, ha1 ha , 2 3 10 ha- x 2x10 mL1, mL1 1, mL-1 4 20 5 control 30 (20 postemergence post emergence ha1. . 16 +3 conclusion fertilizers BR111 (1 2x1 mL- (2 + BR11 ( 2x BR1

RESUMO: Neste estudo avaliou-se a hipótese de que a combinação de Nitrospirillum amazonense estirpe BR11145 com adubo biológico preparado com base em microbioma autóctone da localidade de aplicação do produto, produzido com Microgeo®, resulta em benefícios morfológicos e nutricionais para o desenvolvimento inicial de plantas de cana-de-açúcar e para a química do solo. Para tanto, mudas pré-brotadas de cana-de-açúcar foram crescidas em mesocosmos num experimento conduzido em casa-de-vegetação com solo enriquecido com fertilizante à base de nitrogênio/fósforo/potássio. Os tratamentos avaliados foram: 1) adubo biológico acrescido de N. amazonense (100 mL ha-1), 2) adubo biológico sem o acréscimo de N. amazonense, 3) inoculação de N. amazonense na dose de 100 mL ha-1 (2x108 células viáveis por mL), 4) inoculação de N. amazonense na dose de 200 mL ha-1 (2x108 células viáveis por mL), e 5) testemunha, sem a adição de fertilizante biológico e N. amazonense. O adubo biológico foi aplicado na dose de 300 L ha-1 sendo esta parcelada no plantio (200 L ha-1) e na fase de pós-emergência (100 L ha-1). Após 164 dias do plantio constatou-se aumento no comprimento da folha +3, número de folhas verdes, área foliar e no teor de enxofre nas folhas das plantas de cana-de-açúcar que receberam o adubo biológico combinado com N. amazonense. Conclui-se que a combinação de N. amazonense com o adubo biológico produzido com Microgeo® revelou efeitos positivos por meio de caraterísticas morfológicas e nutricionais em plantas de cana-de-açúcar durante os seus estádios iniciais de desenvolvimento quando comparadas com plantas crescidas apenas com a inoculação de N. amazonense, fertilizante biológico ou fertilizantes minerais, com poucos efeitos positivos notáveis na química do solo. RESUMO avaliouse avaliou se BR BR1114 produto Microgeo canadeaçúcar cana açúcar tanto prébrotadas pré brotadas casadevegetação casa vegetação nitrogêniofósforopotássio nitrogênio fósforo potássio nitrogênio/fósforo/potássio 1 N (10 ha1, ha1 ha , 2 3 10 ha- 2x108 x (2x10 mL, mL) 4 20 5 testemunha 30 (20 pósemergência pós emergência ha1. . 16 constatouse constatou +3 verdes Concluise Conclui minerais BR111 (1 2x10 (2x1 (2 + BR11 ( 2x1 (2x BR1 2x

ABSTRACT Purpose Longitudinally verify the influence of auditory tonal thresholds obtained with transcutaneous and percutaneous bone-anchored hearing aids on speech perception in individuals with external and/or middle ear malformation and chronic otitis media. Methods Observational, retrospective, longitudinal follow-up study of 30 unilateral users of the transcutaneous and percutaneous Baha® system for the collection of secondary data on pure tone thresholds obtained through free field audiometry and sentence recognition threshold in silence and noise in conditions: without the prosthesis; at the time of activation; in the first month of use (post 1); and in the third month (post 2). Results There was a significant difference between pure tone thresholds obtained at frequencies of 3 and 4kHz with better results for the percutaneous technique at all evaluation moments. For both systems, better performance was observed in sentence recognition in silence and in noise, with a significant difference in activation (p<0.001), but it remained stable during the other evaluation moments. The percutaneous system showed better benefit in recognizing sentences in noise only on activation (p=0.036), when compared to the transcutaneous system. Conclusion The percutaneous system provided better audibility for high frequencies; however, such audibility did not influence sentence recognition in the silent situation for both systems. For the noise situation, better responses were observed in the percutaneous system, however, the difference was not maintained over time. boneanchored bone anchored andor or media Observational retrospective followup follow up Baha conditions prosthesis post 1 1) 2. 2 . 2) kHz moments systems p<0.001, p0001 p p<0.001 , 0 001 (p<0.001) p=0.036, p0036 p=0.036 036 (p=0.036) however p000 p<0.00 00 (p<0.001 p003 p=0.03 03 (p=0.036 p00 p<0.0 (p<0.00 p=0.0 (p=0.03 p0 p<0. (p<0.0 p=0. (p=0.0 p<0 (p<0. p=0 (p=0. p< (p<0 p= (p=0 (p< (p= (p

RESUMO Objetivo Verificar longitudinalmente a influência dos limiares tonais auditivos obtidos com as próteses auditivas ancoradas no osso transcutâneas e percutâneas na percepção da fala em indivíduos com malformação de orelha externa e/ou média e Otite Média Crônica. Método Estudo observacional, retrospectivo, de seguimento longitudinal de 30 indivíduos usuários unilaterais de sistema Baha® transcutâneo e percutâneo, para coleta de dados secundários dos limiares tonais obtidos por meio da audiometria em campo livre e do limiar de reconhecimento de sentenças no silêncio e no ruído nas condições: sem a prótese; no momento de ativação; no primeiro mês de uso (pós 1); e no terceiro mês (pós 2). Resultados Houve diferença significante entre os limiares tonais obtidos nas frequências de 3 e 4kHz, com melhores resultados para o percutâneo em todos os momentos de avaliação. Para os dois sistemas, observou-se melhor desempenho no reconhecimento de sentenças no silêncio e ruído, com diferença significante na ativação (p<0,001), porém manteve-se estável nos demais momentos de avaliação. O sistema percutâneo mostrou melhor benefício no reconhecimento de sentenças no ruído apenas na ativação (p=0,036), quando comparado ao transcutâneo. Conclusão O sistema percutâneo possibilitou melhor audibilidade para as frequências altas; contudo, tal audibilidade não influenciou no reconhecimento de sentenças na situação de silêncio para ambos os sistemas. Para a situação de ruído, melhores respostas foram observadas no sistema percutâneo; porém, a diferença não se manteve no decorrer do tempo. eou ou Crônica observacional retrospectivo Baha condições prótese pós 1 1) 2. 2 . 2) 4kHz kHz avaliação sistemas observouse observou p<0,001, p0001 p p<0,001 , 0 001 (p<0,001) mantevese p=0,036, p0036 p=0,036 036 (p=0,036) altas contudo tempo p000 p<0,00 00 (p<0,001 p003 p=0,03 03 (p=0,036 p00 p<0,0 (p<0,00 p=0,0 (p=0,03 p0 p<0, (p<0,0 p=0, (p=0,0 p<0 (p<0, p=0 (p=0, p< (p<0 p= (p=0 (p< (p= (p

Abstract Identification of early haploids is necessary to increase the efficiency of the double haploid production. The objectives were to determine the effectiveness of early selection of haploid seedling and to investigate the haploid inducers and donor tropical supersweet corn interactions, based on stomatal guard cell length. Two haploid inducers, three supersweet corn populations and its six combinations of F1's diploid and haploid, classified based on the expression of the R1-navajo gene and by the colors of the first leaf sheath in seedlings at the V2 stage, were used. From each seedling of the treatments, external epidermal impressions were taken to measure the stomatal guard cell length. F1 haploids showed a 32.7% to 38.2% reduction in guard cell length compared to F1 diploids. The parents contributed differently to reduce or increase guard cell length in the F1's combinations, but without specific interactions between parents. production F1s Fs s F R1navajo Rnavajo R1 navajo R V stage used treatments 327 32 7 32.7 382 38 2 38.2 diploids 3 32. 38.

Abstract Among the potential feed additives, β-glucans are known to positively affect the growth performance, blood parameters, and intestinal microbiota of fish, even the ornamental species. Therefore, the present study evaluated the effects of the dietary supplementation of different Saccharomyces cerevisiae β-glucans concentrations (0, 0.05, 0.1, and 0.2%) in juvenile angelfish (Pterophyllum scalare) over a 42-day period. Regarding growth performance, no effects were observed on most parameters. However, 0.2% β-glucans supplementation produced higher condition factor values, indicating a better nutritional status. Furthermore, β-glucans supplementation did not affect blood parameters. Regarding intestinal microbiota, β-glucans supplementation increased the abundance of the potentially beneficial bacterial genus Phascolarctobacterium. The high abundance of bacteria from the phylum Bacteroidetes, which can degrade β-glucans, may be attributed to the increased abundance of Phascolarctobacterium spp. In addition, 0.2% β-glucans supplementation produced more operational taxonomic units and higher Sobs (observed species richness), indicating effects on the overall bacterial community structure. These results demonstrate the potential application of β-glucans as a dietary supplement to improve the performance and modulate the intestinal microbiota of angelfish. additives βglucans β glucans parameters fish Therefore 0, 0 (0 005 05 0.05 01 1 0.1 02 2 Pterophyllum scalare 42day day 42 period However 0.2 values status Furthermore Bacteroidetes βglucans, glucans, spp addition richness, richness , richness) structure ( 00 0.0 0. 4

Abstract The Cananéia-Iguape Estuarine-Lagoon Complex (CIELC) is an area of low anthropogenic impact; however, it is not completely isolated from human pressure, particularly in the northern sector. Considering this scenario, this study aims to identify the health of two catfish species Cathorops spixii and Genidens Genidens taking into account the hepatic pathological analysis and the accumulation of iron in the form of hemosiderin considering a temporal approach. Biometric measurements were taken, and the condition factor was obtained. The main liver alterations found in the two catfish species were necrosis, inflammation, hemorrhage, cytoplasmatic vacuolization, and pyknosis nuclei. Necrosis (2014: 57%; 2017: 71 %; and 2018: 20%) and pyknosis nuclei (2014: 86%; 2017: 43%; and 2018: 40%) was the most frequent alteration. However, cytoplasmatic vacuolization was the only change that was statistically significant over time. Regarding hemosiderin, catfish livers mostly presented a minimum degree of accumulation, which represents healthy results. Finally, histopathological observations in C. spixii and G. genidens catfish tissues are confirmed to be an efficient tool to evaluate the health of these fish and the changes induced by environmental conditions over the years. However, the absence of significant differences on the histopathological changes over time can suggest a physiological equilibrium of these fish in the CIELC. CananéiaIguape Cananéia Iguape EstuarineLagoon Estuarine Lagoon CIELC (CIELC impact however pressure sector scenario approach taken obtained necrosis inflammation hemorrhage 2014 (2014 57% 57 2017 7 % 2018 20% 20 86% 86 43% 43 40% 40 alteration However results Finally C G years 201 (201 5 2 8 4 (20 (2 (

Abstract This article aims to evaluate the factors that are associated with the consumption of direct cultural goods and services outside the home, considering such consumption as linked to the consumption of other cultural goods and services. The methodology used encompasses the application of a bivariate probit model. To this end, data from the 2017-2018 Family Budget Survey (POF) is used. In general, the results obtained for the model indicate that the consumption of direct cultural goods and services outside the home and the consumption of other cultural goods and services are positively correlated, highlighting the issue of inequality in cultural consumption due to certain social barriers (education, income, access to credit, among others). end 20172018 2017 2018 2017-201 POF (POF general correlated education, education (education income credit others. others . others) 2017201 201 2017-20 201720 20 2017-2 20172 2 2017-

Resumo O presente artigo visa avaliar os fatores que estão associados ao consumo de bens e serviços culturais diretos fora do domicílio, considerando tal consumo como interligado ao consumo de outros bens e serviços culturais. A metodologia empregada engloba a aplicação de um modelo probit bivariado. Para tanto, são utilizados os dados da Pesquisa de Orçamentos Familiares (POF) de 2017-2018. No geral, os resultados obtidos para o modelo indicam que o consumo de bens e serviços culturais diretos fora do domicílio e o consumo de outros bens e serviços culturais são positivamente correlacionados, destacando a questão da desigualdade no consumo cultural devido a certas barreiras sociais (educação, renda, acesso a crédito, entre outros). bivariado tanto POF (POF 20172018. 20172018 2017 2018. 2018 2017-2018 geral correlacionados educação, educação (educação renda crédito outros. . outros) 2017201 201 2017-201 201720 20 2017-20 20172 2 2017-2 2017-