ABSTRACT The worldwide monkeypox (mpox) outbreak in 2022 showed a high frequency of sexually transmitted infections (STI). A cross-sectional study was carried out using secondary data from the Brazilian official mpox surveillance systems. A total of 10,169 mpox cases were identified, with a median age of 32 years. Among them, 92.3% were male at birth and 57.5% were men who have sex with other men (MSM). Approximately 11% were diagnosed with STI, including 5.8% with syphilis and 2.5% with genital herpes. Individuals aged from 25 to 34 years, MSM, individuals with HIV-positive status, and those manifesting skin eruptions or penile edema were associated with STI. Laboratory investigation for mpox must be implemented as a priority in STI clinics (especially for MSM) to mitigate neglected cases, ensure appropriate treatments, and prevent misdiagnoses. (mpox 202 . (STI) crosssectional cross sectional systems 10169 10 169 10,16 identified 3 years them 923 92 92.3 575 57 5 57.5 MSM. MSM (MSM) 11 58 8 5.8 2 2.5 herpes HIVpositive HIV positive status especially treatments misdiagnoses 20 (STI 1016 1 16 10,1 9 92. 57. (MSM 5. 2. 101 10,

Abstract We describe the toxicity of multiwalled carbon nanotubes (MWCNTs) in two aquatic species: Danio rerio and Artemia salina. Fish were exposed to 25 mg L-1, 50 mg L-1, and 100 mg L-1 MWCNTs for 7 days. After exposure, the gills from D. rerio showed lamellar fusion and epithelial lifting in the secondary lamellae, and vasodilation in the primary lamellae. In the gills, heat shock protein 70 and Bax (pro apoptotic member) were stained more intensely in the treated groups than in the control group. The nauplii of A. salina were exposed to 25 µg L-1, 50 µg L-1, and 100 µg L-1 MWCNTs for 96 h. After exposure, the nauplii from the control group presented 20 % mortality, whereas the 25 µg mL-1, 50 µg mL-1, and 100 µg L-1 groups had 46.7 %, 70 %, and 100 % mortality, respectively. The nauplii exposed to 25 µg mL1 and 50 µg mL1 MWCNTs had black aggregates in the intestine because of the uptake of nanomaterials. In addition, the 25 µg mL-1 and 50 µg mL-1 MWCNT groups had black aggregates attached onto the body surface, appendages of the second pair, and mandibles.The results revealed the toxic effects of MWCNTs on the two aquatic organisms, and both species showed great potential for toxicological evaluation of MWCNTs in aquatic environments. (MWCNTs 2 L1, L1 L 1, 1 5 10 L- days exposure D lamellae pro member A 9 h mortality mL1, mL 467 46 46. respectively nanomaterials addition mL- surface pair mandiblesThe mandibles organisms environments 4

RESUMEN | Son pocos estudios que han investigado la movilidad de preescolares con síndrome de Down (SD). En este contexto, los objetivos de este estudio fueron comparar la movilidad de los preescolares con y sin SD, así como comprobar si la función cognitiva y la edad de adquisición de la marcha pueden explicar los resultados de la movilidad. Se trata de un estudio transversal exploratorio con 38 niños: 19 del grupo con SD y 19 del grupo con desarrollo típico (DT). Para evaluar la movilidad se utilizaron la prueba de marcha de 10 metros y la prueba de levantarse y andar cronometrada modificada (mTUG). Los factores exploratorios fueron la puntuación del cribado de la función cognitiva y la edad de adquisición de la marcha. Se utilizaron modelos de regresión lineal múltiple por pasos. Los niños del grupo con SD tenían una velocidad de marcha inferior (p=0,0001) y necesitaban más tiempo para completar la mTUG (p=0,0001). La puntuación del cribado de la función cognitiva y la edad de adquisición de la marcha explicaron la variabilidad en la velocidad de la marcha (R2=0,52; p=0,0001) y el tiempo para completar la prueba (R2=0,68; p=0,0001). Los niños con SD tuvieron peor movilidad en comparación con los niños con DT. Los resultados de la movilidad en este grupo de edad se deben parcialmente a la edad de adquisición de la marcha y a la puntuación del cribado de la función cognitiva. SD. . (SD) contexto 3 1 DT (DT) mTUG. (mTUG) pasos p=0,0001 p00001 p 0 0001 (p=0,0001 p=0,0001. R2=0,52 R2052 R R2 52 (R2=0,52 R2=0,68 R2068 68 (R2=0,68 (SD (DT (mTUG p=0,000 p0000 000 (p=0,000 R2=0,5 R205 5 (R2=0,5 R2=0,6 R206 6 (R2=0,6 p=0,00 p000 00 (p=0,00 R2=0, R20 (R2=0, p=0,0 p00 (p=0,0 R2=0 (R2=0 p=0, p0 (p=0, R2= (R2= p=0 (p=0 (R2 p= (p= (R (p

ABSTRACT | Few studies have investigated the mobility of preschool age children with Down syndrome (DS). This study aimed to compare the mobility of preschool age children with and without DS and to verify if cognitive function and gait acquisition age may explain mobility outcomes. This was an exploratory cross-sectional study involving 38 children: 19 in the DS group and 19 in the typical development (TD) group. The 10-meter walk test and the modified Timed Up and Go (mTUG) test were used to evaluate mobility. The explanatory factors were the cognitive function screening test score and the age of gait acquisition. Stepwise multiple linear regression models were used. The children in the DS group had slower gait speed (p=0.0001) and took longer to complete the mTUG test (p=0.0001). The cognitive function screening test score and age of gait acquisition explained the variability in gait speed (R 2 =0.52; p=0.0001) and the variability in the time to complete the mTUG test (R 2 =0.68; p=0.0001). Children with DS showed a poorer mobility when compared to the children in the TD group. The outcomes of mobility in this age group were partially explained by the age of gait acquisition and the cognitive function screening test score. DS. . (DS) crosssectional cross sectional 3 1 (TD 10meter meter 10 (mTUG p=0.0001 p00001 p 0 0001 (p=0.0001 p=0.0001. R =0.52 052 52 =0.68 068 68 (DS p=0.000 p0000 000 (p=0.000 =0.5 05 5 =0.6 06 6 p=0.00 p000 00 (p=0.00 =0. p=0.0 p00 (p=0.0 =0 p=0. p0 (p=0. = p=0 (p=0 p= (p= (p

RESUMO | Poucos estudos investigaram a mobilidade de pré-escolares com síndrome de Down (SD). Dessa forma, os objetivos desta pesquisa foram comparar a mobilidade de pré-escolares com e sem SD, bem como verificar se a função cognitiva e a idade de aquisição da marcha podem explicar os desfechos de mobilidade. Estudo transversal exploratório com 38 crianças: 19 do grupo SD e 19 do grupo desenvolvimento típico (DT). O teste de caminhada de 10 metros e o timed up and go modificado (mTUG) foram utilizados para avaliar a mobilidade. Os fatores exploratórios foram: a pontuação da triagem da função cognitiva e a idade de aquisição da marcha. Foram usados modelos de regressão linear múltipla stepwise . As crianças do grupo SD apresentaram menor velocidade de marcha (p=0,0001) e necessitaram de mais tempo para completar o mTUG (p=0,0001). A pontuação da triagem da função cognitiva e a idade de aquisição da marcha explicaram a variabilidade na velocidade da marcha (R 2 =0,52; p=0,0001) e o tempo para completar o teste mTUG (R 2 =0,68; p=0,0001). Crianças com SD apresentaram pior capacidade de mobilidade quando comparadas às com DT. Os desfechos de mobilidade nessa faixa etária foram parcialmente explicados pela idade de aquisição da marcha e pelo escore da triagem da função cognitiva. préescolares pré escolares SD. (SD) forma 3 1 DT (DT) (mTUG p=0,0001 p00001 p 0 0001 (p=0,0001 p=0,0001. R =0,52 052 52 =0,68 068 68 (SD (DT p=0,000 p0000 000 (p=0,000 =0,5 05 5 =0,6 06 6 p=0,00 p000 00 (p=0,00 =0, p=0,0 p00 (p=0,0 =0 p=0, p0 (p=0, = p=0 (p=0 p= (p= (p

Abstract The objective of the current study was to carry out a survey of the main anatomopathological alterations in raising quails and evaluate possible interference of these in the bone tissue. To obtain the data, 23 quails were collected from farm in the central Serrana region of Espírito Santo. Necropsies with macroscopic descriptions, microbiological, coproparasitological, radiographic and histomorphometric tests were carried out. It was done data descriptive analysis and average comparision using Student T test. It was found that they presented lesions predominantly in the digestive system, followed by urinary and reproductive, and muscular system, were the altered color of the liver (47%) was the most frequent lesion. In the parasitological exams, it was found oocysts of Eimeira sp. (39.13%). In the microbiological exams, it was detected predominantly Escherichia coli (83%). Moderate osteopenia in quails, but the percentage of trabecular bone on bones was similar between healthy and diseased quails, without bone changes in histology. Microscopically, it was observed lung congestion as predominant lesion. It is concluded that there was predominance of alterations in the digestive system and mild parasitic infection; and although there was moderate level of osteopenia, there wasn’t bone change as a result of the observed infections. tissue 2 Santo descriptions coproparasitological test reproductive 47% 47 (47% lesion exams sp 39.13%. 3913 39.13% . 39 13 (39.13%) 83%. 83 83% (83%) histology Microscopically infection wasnt wasn t infections 4 (47 391 39.13 3 1 (39.13% 8 (83% (4 39.1 (39.13 (83 ( 39. (39.1 (8 (39. (39 (3

RESUMEN El déficit de conocimientos entre los profesionales de la salud ha sido una barrera para la expansión e implementación de los servicios de rehabilitación pulmonar (RP) a pesar de sus beneficios comprobados para las personas con enfermedad respiratoria crónica (ERC). Este estudio de encuesta forma parte de un proyecto más amplio para implantar la RP en el sistema público sanitario brasileño mediante la evaluación de la preparación de los profesionales sanitarios de dos municipios brasileños para proporcionarla. Se utilizó un cuestionario autoadministrado para evaluar los conocimientos (19 preguntas), la formación (7 preguntas), la confianza (10 preguntas) y la experiencia clínica (8 preguntas) de los fisioterapeutas (FT) y del equipo multiprofesional (EM), aplicado previamente en un taller sobre RP. La puntuación media de los conocimientos fue de 10±3 para FT y de 6±3 para EM. Menos de un tercio de los FT afirmaron que tenían “mucha” experiencia (25%) y confianza (22,7%) para realizar la RP, así como formación suficiente para realizar la prueba de la marcha de seis minutos (27,3%). Pocos profesionales del EM declararon que tenían “mucha” experiencia (10%) y formación suficiente (4,8%) para realizar la RP, así como para planificar el programa educativo (10%) y tenían confianza para derivar a pacientes para la RP (6,5%). Este es el primer estudio que evalúa la preparación de los profesionales de la red pública de salud en Brasil para proporcionar la RP, y se observa que, en los municipios donde se realizó, tanto los FT como el EM están poco preparados para llevarla a cabo, lo que refuerza la necesidad de una formación continuada. (RP ERC. ERC . (ERC) proporcionarla 19 (1 preguntas, preguntas , 7 ( 10 8 (FT EM, (EM) 103 3 10± 63 6 6± mucha “mucha 25% 25 (25% 22,7% 227 22 (22,7% 27,3%. 273 27,3% 27 (27,3%) 10% (10% 4,8% 48 4 (4,8% 6,5%. 65 6,5% 5 (6,5%) realizó cabo continuada (ERC 1 (EM 2 (25 22,7 (22,7 27,3 (27,3% 4,8 (4,8 6,5 (6,5% (2 22, (22, 27, (27,3 4, (4, 6, (6,5 (22 (27, (4 (6, (27 (6

ABSTRACT The knowledge deficit of health professionals has been a barrier to expanding and implementing of pulmonary rehabilitation (PR) services, despite the reported benefits of PR for individuals with Chronic Respiratory Disease (CRD). This study aims to assess the preparedness of health care professionals from two Brazilian cities to perform PR in the public health system. This is survey is part of a larger project to implement PR in the Brazilian public health system. A self-administered questionnaire was used to assess the knowledge (19 questions), training (7 questions), confidence (10 questions), and clinical experience (8 questions) of physical therapists (PT) and the multiprofessional team (MT) before a PR workshop. In total, 44 PT and 231 MT answered the questionnaire. The mean total knowledge score was 10±3 for PT and 6±3 for MT. Few physical therapist reported having “a lot” of experience (25%) and confidence (22.7%) to perform PR, as well as sufficient training to conduct the six-minute walk test (27.3%).Even fewer MT reported having “a lot” of experience (10%) and sufficient training (4.8%) to perform PR, as well as to plan the educational program for patients (10%) and the confidence to refer patients to PR (6.5%). This is the first study to evaluate the preparedness of professionals from the Brazilian public health network to provide PR. Notably, both PT and MT have low preparation to perform PR in the studied cities, reinforcing the need for continuing education. (PR services CRD. CRD . (CRD) system selfadministered self administered 19 (1 questions, questions , 7 ( 10 8 (PT (MT workshop 4 23 103 3 10± 63 6 6± lot 25% 25 (25% 22.7% 227 22 (22.7% sixminute six minute 27.3%.Even 273Even Even 27.3% .Even 27 10% (10% 4.8% 48 (4.8% 6.5%. 65 6.5% 5 (6.5%) Notably education (CRD 1 2 (25 22.7 (22.7 273 27.3 4.8 (4.8 6.5 (6.5% (2 22. (22. 27. 4. (4. 6. (6.5 (22 (4 (6. (6

RESUMO O déficit de conhecimento dos profissionais de saúde tem sido uma barreira para a expansão e implementação dos serviços de reabilitação pulmonar (RP), apesar dos seus benefícios comprovados para indivíduos com doença respiratória crônica (DRC). Objetivo: avaliar o preparo dos profissionais de saúde de dois municípios brasileiros para fornecer a RP no sistema público de saúde. Esse estudo, do tipo survey, foi parte de um projeto maior para implementação da RP no sistema público de saúde brasileiro. Foi utilizado um questionário autoaplicável para avaliar o conhecimento (19 questões), o treinamento (7 questões), a confiança (10 questões) e a experiência clínica (8 questões) dos fisioterapeutas (FT) e da equipe multiprofissional (EM), aplicado antes de um workshop sobre RP. No total, 44 FT e 231 EM responderam o questionário. A pontuação média de conhecimento foi de 10±3 para FT e 6±3 para EM. Poucos FT referiam ter “muita” experiência (25%) e confiança (22,7%) para realizar RP, bem como treinamento suficiente para realizar o teste de caminhada de seis minutos (27,3%). Ainda menos profissionais da EM relataram ter “muita” experiência (10%) e treinamento suficiente (4,8%) para realizar RP, assim como para planejar o programa educacional dos pacientes (10%) e ter confiança para encaminhar pacientes para a RP (6,5%). Este é o primeiro estudo a avaliar o preparo dos profissionais da rede pública de saúde no Brasil para fornecer RP. Notavelmente, tanto FT quanto EM têm baixo preparo para realizar RP nos municípios estudados, reforçando a necessidade de realização de educação continuada. , (RP) DRC. DRC . (DRC) Objetivo survey brasileiro 19 (1 questões, questões 7 ( 10 8 (FT EM, (EM) total 4 23 103 3 10± 63 6 6± muita “muita 25% 25 (25% 22,7% 227 22 (22,7% 27,3%. 273 27,3% 27 (27,3%) 10% (10% 4,8% 48 (4,8% 6,5%. 65 6,5% 5 (6,5%) Notavelmente estudados continuada (RP (DRC 1 (EM 2 (25 22,7 (22,7 27,3 (27,3% 4,8 (4,8 6,5 (6,5% (2 22, (22, 27, (27,3 4, (4, 6, (6,5 (22 (27, (4 (6, (27 (6

Abstract Introduction Takayasu’s arteritis (TAK) patients are at an elevated risk of metabolic syndrome and cardiovascular diseases (CVD). Currently, there are no well-validated biomarkers to assess this risk in this population. Previous research in different cohorts has linked serum levels of osteoprotegerin (OPG) and its polymorphisms to accelerated atherosclerosis and a marker of poor prognosis in CVD. Thus, we assessed this protein as a potential biomarker of CVD in TAK patients. Objectives To evaluate the serum levels of OPG and its SNPs (single nucleotide polymorphisms) in TAK patients and healthy controls, and to associate these parameters with clinical data. Methods This bicentric cross-sectional study included TAK patients who were compared with healthy individuals (control group). The serum levels of OPG and the frequency of OPG SNPs [1181G > C (rs2073618), 245 A > C (rs3134069), 163T > C (rs3102735), and 209 C > T (rs3134070)] were compared between the both groups and associated with clinical data. Results In total, 101 TAK patients and 93 controls were included in the study. The serum levels of OPG (3.8 ± 1.9 vs. 4.3 ± 1.8pmol/L, respectively; P = 0.059), and its four polymorphisms were comparable between both groups. In an additional analysis of only TAK patients, serum OPG levels and its four genes were not associated with any CVD parameters, except for higher OPG levels among patients without dyslipidemia. Conclusion No significant differences were observed in serum OPG levels or in the genotype frequencies of OPG SNPs between the patient and control groups. Similarly, no correlation was found between laboratory parameters and clinical data on CVD risk in TAK patients. Takayasus Takayasu s (TAK . (CVD) Currently wellvalidated well validated population (OPG Thus single crosssectional cross sectional group. group group) 1181G G rs2073618, rs2073618 rs , (rs2073618) 24 rs3134069, rs3134069 (rs3134069) rs3102735, rs3102735 (rs3102735) 20 rs3134070 (rs3134070) total 10 9 3.8 38 3 8 (3. 19 1 1. vs 43 4 4. 18pmolL pmolL 8pmol L pmol 1.8pmol/L respectively 0.059, 0059 0.059 0 059 0.059) dyslipidemia Similarly (CVD rs207361 (rs2073618 2 rs313406 (rs3134069 rs310273 (rs3102735 rs313407 (rs3134070 3. (3 005 0.05 05 rs20736 (rs207361 rs31340 (rs313406 rs31027 (rs310273 (rs313407 ( 00 0.0 rs2073 (rs20736 rs3134 (rs31340 rs3102 (rs31027 0. rs207 (rs2073 rs313 (rs3134 rs310 (rs3102 rs20 (rs207 rs31 (rs313 (rs310 rs2 (rs20 rs3 (rs31 (rs2 (rs3 (rs

Abstract The objective was to analyze the spatial distribution of pregnancy in children under 14 years and six months by Brazilian region and municipality and sociodemographic and health characteristics of pregnant women and live births. Ecological study analyzing the Live Birth Information System (SINASC) from 2011 to 2021 in three age groups (< 14 years and six months, 15-19 years, and 20 years and above) by demographic and birth variables. We applied the Global and Local Moran. A total of 127,022 live births to girls aged 10-14 years were identified during the period, most of whom were Black, 21.1% in common-law or married relationships, with a lower proportion of seven prenatal care appointments and enrollment in the first trimester, a higher proportion of low birth weight and low Apgar score, residing in the North and Northeast. The mean live birth rate for 10-to-14-year-old girls was significantly autocorrelated with space, especially in municipalities of the Midwest and North. Pregnancy from 10 to 14 years of age reveals several vulnerabilities suffered by these girls due to pregnancy at an early age, which is more common among Black women, with implications for morbimortality for them and their children and the presumed violence in these cases, including denied access to legal abortion.

Resumo O objetivo foi analisar a distribuição espacial da gravidez em menores de 14 anos e seis meses segundo regiões e municípios brasileiros e características sociodemográficas e de saúde das parturientes e nascidos vivos. Estudo ecológico, analisando o Sistema de Informação sobre Nascidos Vivos (SINASC), 2011-2021, em três grupos etários (<14 anos e 6 meses, 15-19 e 20 anos e mais), segundo variáveis demográficas e do parto. Foram aplicados os Índices Global e Local de Moran. No período foram 127.022 nascidos vivos de meninas 10-14 anos, na maioria negras, 21,1% em união estável ou casadas, com menor proporção de 7 consultas de pré-natal e captação no primeiro trimestre, maior proporção de baixo peso ao nascer e baixo índice de Apgar, residentes nas regiões Norte e Nordeste. A taxa média de nascidos vivos de 10-14 anos mostrou autocorrelação significativa com o espaço, especialmente em municípios do Centro-Oeste e Norte. A gravidez de 10 a 14 revela uma sequência de vulnerabilidades sofridas por essas meninas, pela gravidez em idade precoce, maior frequência entre negras, com implicações na morbimortalidade para ela e seus filhos; e pela violência presumida nesses casos, incluindo o acesso negado ao aborto legal.

Abstract The objective was to analyze the spatial distribution of pregnancy in children under 14 years and six months by Brazilian region and municipality and sociodemographic and health characteristics of pregnant women and live births. Ecological study analyzing the Live Birth Information System (SINASC) from 2011 to 2021 in three age groups (< 14 years and six months, 15-19 years, and 20 years and above) by demographic and birth variables. We applied the Global and Local Moran. A total of 127,022 live births to girls aged 10-14 years were identified during the period, most of whom were Black, 21.1% in common-law or married relationships, with a lower proportion of seven prenatal care appointments and enrollment in the first trimester, a higher proportion of low birth weight and low Apgar score, residing in the North and Northeast. The mean live birth rate for 10-to-14-year-old girls was significantly autocorrelated with space, especially in municipalities of the Midwest and North. Pregnancy from 10 to 14 years of age reveals several vulnerabilities suffered by these girls due to pregnancy at an early age, which is more common among Black women, with implications for morbimortality for them and their children and the presumed violence in these cases, including denied access to legal abortion. 1 SINASC (SINASC 201 202 < ( 1519 15 19 15-1 2 above variables Moran 127022 127 022 127,02 1014 10-1 period 211 21 21.1 commonlaw law relationships trimester score Northeast 10to14yearold toyearold year old space cases abortion 151 15- 12702 12 02 127,0 101 10- 21. yearold 1270 0 127,

Resumo O objetivo foi analisar a distribuição espacial da gravidez em menores de 14 anos e seis meses segundo regiões e municípios brasileiros e características sociodemográficas e de saúde das parturientes e nascidos vivos. Estudo ecológico, analisando o Sistema de Informação sobre Nascidos Vivos (SINASC), 2011-2021, em três grupos etários (<14 anos e 6 meses, 15-19 e 20 anos e mais), segundo variáveis demográficas e do parto. Foram aplicados os Índices Global e Local de Moran. No período foram 127.022 nascidos vivos de meninas 10-14 anos, na maioria negras, 21,1% em união estável ou casadas, com menor proporção de 7 consultas de pré-natal e captação no primeiro trimestre, maior proporção de baixo peso ao nascer e baixo índice de Apgar, residentes nas regiões Norte e Nordeste. A taxa média de nascidos vivos de 10-14 anos mostrou autocorrelação significativa com o espaço, especialmente em municípios do Centro-Oeste e Norte. A gravidez de 10 a 14 revela uma sequência de vulnerabilidades sofridas por essas meninas, pela gravidez em idade precoce, maior frequência entre negras, com implicações na morbimortalidade para ela e seus filhos; e pela violência presumida nesses casos, incluindo o acesso negado ao aborto legal. 1 ecológico SINASC, SINASC , (SINASC) 20112021, 20112021 2011 2021, 2021 2011-2021 <14 (<1 1519 15 19 15-1 2 mais, mais mais) parto Moran 127022 127 022 127.02 1014 10-1 negras 211 21 21,1 casadas prénatal pré natal trimestre Apgar Nordeste espaço CentroOeste Centro Oeste precoce filhos casos legal (SINASC 2011202 201 202 2011-202 <1 (< 151 15- 12702 12 02 127.0 101 10- 21, 201120 2011-20 < ( 1270 0 127. 20112 2011-2 2011-

Resumen El objetivo principal del presente estudio es comprender cuáles son los criterios que influyen en el proceso de toma de decisiones de selección de las mejores startups en innovación por parte de un fondo de capital de riesgo, a juicio de los inversores, profesionales de fondos de capital de riesgo y emprendedores de startups entrevistados. Presentamos algunas ideas sobre las características de las principales ciudades que promueven la innovación y los principios del modernismo, del modernismo crítico (Habermas) y del pensamiento creativo (Einstein). Las entrevistas confirmaron varias relaciones entre las hipótesis encontradas en la literatura sobre teoría organizacional. A través del análisis de las entrevistas, se corroboraron hallazgos como los entornos posburocráticos (Heckscher) y la propuesta de adhocracia de Mintzberg (1995), así como la teoría de la elección racional de Herbert Simon (1987) y sus estudios sobre el proceso de toma de decisiones en las organizaciones a través del reconocimiento de patrones cognitivos por parte de los decisores. También se destacó la importancia del tema de la resiliencia organizacional. Finalmente, se sugiere estudiar la apertura de nuevos espacios para la creación de startups e innovación, como la Station F, en París, el espacio La Nave en Madrid, el proyecto Porto Maravilha, en Río de Janeiro, y de centros urbanos de innovación como Vila Olímpia y Avenida Paulista, en São Paulo. inversores entrevistados Habermas (Habermas Einstein. Einstein . (Einstein) organizacional Heckscher (Heckscher 1995, 1995 , (1995) 1987 (1987 decisores Finalmente F París Madrid Maravilha Janeiro Paulista Paulo (Einstein 199 (1995 198 (198 19 (199 (19 1 (1 (

Abstract This study aims to understand the criteria that influence the decision-making process of selecting startups that have innovated successfully. In this article, this kind of selection was made by venture capital enterprises. We studied the view of the investors, venture capital professionals, and startup entrepreneurs interviewed. We present the actual global characteristics of the main cities where innovation takes place and the modernism and critical modernism aspects and creative thinking beliefs (Einstein, Habermas). The qualitative research was carried out using an exploratory approach and case study methodology based on semi-structured interviews (nine in total) with professionals from venture capital funds, startup entrepreneurs, and investors. The interviews confirmed several relationships between theories found in the business management literature. Findings such as post-bureaucratic environments (Heckscher), Mintzberg’s (1995) Adhocracy, and Simon’s decision-making process (1987) for pattern recognition were corroborated by the analysis of the interviews. We present some initiatives for innovation such as Station F in France, El Espacio La Nave, Madrid, the Project Porto Maravilha in Rio, and Vila Olimpia e Paulista avenue, São Paulo. decisionmaking decision making successfully article enterprises investors interviewed Einstein, Einstein (Einstein Habermas. Habermas . Habermas) semistructured semi structured nine total funds literature postbureaucratic post bureaucratic Heckscher, Heckscher , (Heckscher) Mintzbergs Mintzberg s 1995 (1995 Adhocracy Simons Simon 1987 (1987 France Nave Madrid Rio avenue Paulo (Heckscher 199 (199 198 (198 19 (19 1 (1 (

Resumo O objetivo principal do presente estudo é entender quais critérios influenciam o processo decisório de seleção das melhores startups em inovação por um fundo de venture capital, na visão dos investidores, profissionais de fundos de venture capital e empreendedores de startups entrevistados. Apresentamos algumas ideias sobre as características das principais cidades que promovem inovação e os ideais do modernismo e do modernismo crítico (Habermas) e do pensamento criativo (Einstein). As entrevistas confirmaram diversas relações entre as hipóteses encontradas na literatura sobre teoria organizacional. Achados como os ambientes pós-burocráticos (Heckscher) e a proposta de adhocracia de Mintzberg (1995), assim como a Teoria da Escolha Racional de Herbert Simon (1987) e seus estudos sobre o processo decisório nas organizações pelo reconhecimento de padrões cognitivos pelos decididores, foram corroborados pela análise das entrevistas. Foram elaboradas entrevistas semiestruturadas (nove, no total) com profissionais de fundos de venture capital, empreendedores de startups e investidores com alguma experiência no mercado em questão. A importância do tema resiliência organizacional também foi ressaltada, e, no fim, sugere-se o estudo sobre a abertura de novos espaços de criação de startups e inovação, como a Station F, em Paris, França, o espaço La Nave, em Madri, e o projeto Porto Maravilha, no Rio, e de centros urbanos de inovação, como a Vila Olímpia e a Avenida Paulista, em São Paulo. entrevistados Habermas (Habermas Einstein. Einstein . (Einstein) pósburocráticos pós burocráticos Heckscher (Heckscher 1995, 1995 , (1995) 1987 (1987 decididores nove, nove (nove total questão ressaltada fim sugerese sugere se F Paris França Nave Madri Maravilha Rio Paulista Paulo (Einstein 199 (1995 198 (198 19 (199 (19 1 (1 (

ABSTRACT Toxoplasmosis is an infection of vast worldwide distribution whose etiologic agent is Toxoplasma gondii. This disease can cause problems ranging from mild symptoms to serious conditions, such as encephalitis, miscarriage and blindness. Therefore, it is of utmost importance to perform a diagnosis with reproducible techniques in order to obtain a good prognosis. The aim of this review was to analyze the efficiency of toxoplasmosis diagnostic techniques based on sensitivity and specificity results. Five research platforms in English language were used (Eric, Elsevier, Google Scholar, PubMed and SciELO), which contained data on the diagnosis of toxoplasmosis. The search and selection were performed for studies published prior to June 2021. The search resulted in the inclusion of 13 articles published from 2005 to 2020. The data revealed the use of different samples in the standardization of techniques such as serum, total blood, colostrum and amniotic fluid. The flow cytometry, lateral flow immunoassay and qPCR techniques showed 100% sensitivity, whereas the ELISA, western blotting, qPCR and RE-LAMP techniques achieved 100% specificity. Significantly, the qPCR and LAMP techniques were more accurate when the likelihood ratio was assessed. The meta-analysis identified that ISAGA and western blotting have low sensitivity values and LIASON, ELFA and ELISA, using a silica bioconjugate, also have low specificity values. It was noted that a wide range of methods have high values of sensitivity and specificity. Therefore, the choice of the method will be based on the conditions and its financial viability. gondii encephalitis blindness Therefore prognosis results Eric, Eric (Eric Elsevier Scholar SciELO, SciELO , SciELO) 2021 1 200 2020 serum blood fluid cytometry 100 ELISA RELAMP RE Significantly assessed metaanalysis meta analysis LIASON bioconjugate viability 202 20 10 2

Abstract The pandemic caused by coronavirus has resonated throughout different levels of health care in Brazil and, in this context, the present research aimed to evaluate this impact on tertiary dental care provided by the Unified Health System (SUS). Therefore, an ecological study was conducted with data obtained from the Hospital Information System processed by the Portal of the Department of Informatics of SUS. The sample consisted of patients of all sexes and age groups, whose Hospital Admission Authorizations (AIHs) were approved for dental tertiary care procedures from January 2015 to December 2020. Descriptive analyses and the ANOVA test with a significance level set at p < 0.05 were used. When the annual mean numbers of AIHs approved were evaluated, findings showed that on an average, the Southeast region authorized a higher number of procedures (p-value < 0.001), however, in the pandemic year (2020), a reduction of approximately 24.5% of these hospitalizations occurred throughout Brazil, with the Midwest being the region most affected (32.12%). A percentage increase occurred in the Surgical Treatment of Oral sinus/Oral nasal Fistula (16.1%), in addition to a significant decrease in performing procedures for Resection of Mouth Lesion (33.4%). In the pandemic year, there was a reduction of 14% in expenditures related to hospital services and 23.26% related to professional services. It was concluded that the data presented demonstrated a significant reduction in AIHs for tertiary dental care in the pandemic year. context SUS . (SUS) Therefore groups (AIHs 201 2020 005 0 05 0.0 used evaluated average pvalue value 0.001, 0001 0.001 , 001 0.001) however 2020, (2020) 245 24 5 24.5 32.12%. 3212 32.12% 32 12 (32.12%) sinusOral sinus 16.1%, 161 16.1% 16 1 (16.1%) 33.4%. 334 33.4% 33 4 (33.4%) 14 2326 23 26 23.26 (SUS 20 202 00 0. 000 0.00 (2020 2 24. 321 32.12 3 (32.12% 16.1 (16.1% 33.4 (33.4% 232 23.2 (202 32.1 (32.12 16. (16.1 33. (33.4 23. (20 32. (32.1 (16. (33. (2 (32. (16 (33 ( (32 (1 (3

SUMMARY OBJECTIVE: The purpose of this study was to investigate the details of minor complications of carotid artery stenting in a developing country. METHODS: This was a retrospective, single-center study conducted on the target group consisting of 65 symptomatic patients who underwent carotid artery stenting. We assessed technical success rate, periprocedural complication within 30 days (hypotension, bradycardia, acute kidney injury, vasospasm, a transient ischemic attack, stroke, myocardial infarction, and death), and the differences between groups with and without complications. RESULTS: Minor periprocedural complications occurred in 15 patients. In all, 8 (12.3%) had transient hypotension, 6 (9.2%) had bradycardia, 7 (10.7%) had acute kidney injury, 2 (3.1%) had vasospasm, and 1 (1.5%) had transient ischemic attack. A greater rate of minor complications was observed in women (p=0.051). CONCLUSION: The results of the carotid artery stenting procedures performed in a developing country were acceptable. OBJECTIVE METHODS retrospective singlecenter single center 3 hypotension (hypotension bradycardia injury vasospasm attack stroke infarction death, death , death) RESULTS all 12.3% 123 12 (12.3% 9.2% 92 9 (9.2% 10.7% 107 10 (10.7% 3.1% 31 (3.1% 1.5% 5 (1.5% p=0.051. p0051 p p=0.051 . 0 051 (p=0.051) CONCLUSION acceptable 12.3 (12.3 9.2 (9.2 10.7 (10.7 3.1 (3.1 1.5 (1.5 p005 p=0.05 05 (p=0.051 12. (12. 9. (9. 10. (10. 3. (3. 1. (1. p00 p=0.0 (p=0.05 (12 (9 (10 (3 (1 p0 p=0. (p=0.0 ( p=0 (p=0. p= (p=0 (p= (p

ABSTRACT Objective: the aim of this study was to compare the results of open and videolaparoscopic transvesical prostatectomy techniques in the treatment of benign prostatic hyperplasia (BPH) in a tertiary hospital. Methods: we reviewed medical records of patients who underwent transvesical adenectomy due to BPH between March 2019 and March 2021 at the urology service of Hospital de Clínicas do Paraná (HCPR), 42 patients were included in the open transvesical prostatectomy group and 22 in the videolaparoscopic group. Then, a comparison was made between the techniques in terms of surgical time, bleeding, length of stay, need for intensive care, among others, in addition to postoperative outcome. Results: the mean surgical time was shorter in the open technique compared to the laparoscopic technique (141 min vs 274 min). The videolaparoscopic group had a shorter mean hospital stay (3.5 days vs 6.36 days). There was no statistical significance in the comparison regarding the need for an intensive care unit, as well as in the assessment of postoperative bleeding. Conclusion: comparatively, the techniques demonstrated a similar outcome, with a low rate of complications and satisfactory results for the treatment of BPH. The laparoscopic technique is a surgery with a shorter hospital stay, but at the expense of a longer surgical time. Objective (BPH Methods 201 202 HCPR, HCPR , (HCPR) 4 2 Then bleeding others outcome Results 141 (14 27 min. . min) 3.5 35 3 5 (3. 636 6 36 6.3 days. days) unit Conclusion comparatively 20 (HCPR 14 (1 3. (3 63 6. 1 (

RESUMO Objetivo: o objetivo deste estudo foi comparar o resultado das técnicas de prostatectomia transvesical aberta e videolaparoscópica no tratamento de hiperplasia prostática benigna (HPB) em um hospital terciário. Métodos: foram revisados prontuários de pacientes submetidos a adenectomia transvesical devido a HPB entre março de 2019 a março de 2021 no serviço de urologia do Hospital de Clínicas do Paraná (HCPR), sendo incluídos 42 pacientes no grupo prostatectomia transvesical aberta e 22 no grupo videolaparoscópico. Em seguida foi feita a comparação entre as técnicas nos quesitos tempo cirúrgico, sangramento, tempo de internamento, necessidade de terapia intensiva, entre outras, além de desfecho pós-operatório. Resultados: o tempo cirúrgico médio foi menor na técnica aberta em comparação com a técnica videolaparoscópica (141 min vs 274 min). O grupo videolaparoscópico apresentou um tempo médio de internamento menor (3,5 dias vs 6,36 dias). Não houve significância estatística na comparação quanto a necessidade de unidade de terapia intensiva, assim como na avaliação do sangramento pós-operatório. Conclusão: comparativamente, as técnicas demonstraram um desfecho semelhante, com baixa taxa de complicações e resultados satisfatórios para o tratamento da HPB. Sendo a técnica videolaparoscópica uma cirurgia com menor tempo de internamento, porém às custas de um maior tempo cirúrgico. . Objetivo (HPB terciário Métodos 201 202 HCPR, HCPR , (HCPR) 4 2 intensiva outras pósoperatório. pósoperatório pós operatório. operatório pós-operatório Resultados 141 (14 27 min. min) 3,5 35 3 5 (3, 636 6 36 6,3 dias. dias) Conclusão comparativamente semelhante 20 (HCPR 14 (1 3, (3 63 6, 1 (

Abstract Accumulated evidence has shown that the oral cavity may be an important reservoir for SARS-CoV-2. Some authors have suggested that the use of mouthrinses could reduce SARS-CoV-2 viral load in the saliva. Thus, the aim of this review was to synthesize evidence about the efficacy of mouthrinses in reducing the salivary viral load of SARS-CoV-2. 2. Nine randomized controlled trials (RCTs) have investigated the efficacy of different mouthrinses in reducing salivary SARS-CoV-2 loads. Various active ingredients have been tested in these trials: 0.5%,1% and 2% povidone-iodine, 0.2% and 0.12% chlorhexidine (CHX), 0.075% cetylpyridinium chloride (CPC), 0.075% CPC with Zinc lactate, 1% and 1.5% hydrogen peroxide (HP), 1.5% HP + 0.12% CHX and ß-cyclodextrin and citrox. The studies reported an intra-group reduction in the salivary levels of the virus, when compared with the baseline. However, the majority of these trials failed to demonstrate a significant inter-group difference between active groups and the control group relative to the decrease in salivary SARS-CoV-2 loads. Although promising, these results should be confirmed by larger trials. SARSCoV2. SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- saliva Thus RCTs (RCTs loads 051 0 5 1 0.5%,1 povidoneiodine, povidoneiodine povidone iodine, iodine povidone-iodine 02 0.2 012 12 0.12 CHX, , (CHX) 0075 075 0.075 CPC, (CPC) lactate 15 1.5 HP, (HP) ßcyclodextrin ß cyclodextrin citrox intragroup intra virus baseline However intergroup inter promising SARS-CoV 05 0.5%, 0. 01 0.1 (CHX 007 07 0.07 (CPC 1. (HP 0.5% 00 0.0 0.5