Abstract Background Tuberous sclerosis complex (TSC) is a multisystem neurocutaneous syndrome with variable phenotypes. Recent updates of TSC diagnostic criteria reaffirmed the defined genetic diagnostic criterion as the finding of a pathogenic DNA alteration in either TSC1 or TSC2 genes. It also slightly modified definite clinical diagnostic criteria. TSC-associated skin lesions in infancy are important clinical signs to select individuals with possible TSC for a closer clinical follow-up and genetic testing. Objective To raise awareness of the updated TSC diagnosis criteria; to assess the frequency of skin lesions in TSC patients as well as the first dermatological presentation; and to associate the findings with either TSC1 or TSC2 mutations. Methods Observational cross-sectional study. Clinical and genetic data were retrospectively collected from 37 TSC patients from a Brazilian University Hospital. Patients with skin signs were examined and prospectively assessed for 12 months. Results The earliest cutaneous lesions were hypomelanotic macules, which together with angiofibromas were the most frequent dermatological lesions. The total pathogenic DNA alteration ratio between TSC2 and TSC1 genes was 8:1. The frequency of a TSC2 pathogenic variant was 10-fold greater in the presence of ungual fibromas. Study limitations Small sample and a limited number of patients with TSC1 pathogenic variants. Conclusion Clinicians should be knowledgeable about TSC updated diagnostic criteria. Patients need to be followed up by a multidisciplinary team and treated accordingly. Early detection of cutaneous lesions is important for TSC diagnosis. A significant association between TSC2 gene pathogenic alterations and ungual fibromas is described. (TSC phenotypes TSCassociated associated followup follow testing presentation mutations crosssectional cross sectional study 3 Hospital 1 months macules 81. 81 8 1. 8:1 10fold fold 10 variants accordingly described 8:

Introduction: Cholesteatoma, although relatively rare, presents significant challenges in clinical practice. Despite decades of research, its cause remains complex and elusive. Objective: This review aimed to summarize key findings on the epidemiology, pathophysiology, diagnosis and surgical management of cholesteatoma, highlighting current knowledge gaps and emerging trends in the field. Method: Narrative review carried out in the PubMed and Scielo databases. The search used the following keywords: “cholesteatoma, petros apex, minimally invasive surgical procedures”. The inclusion criteria comprised review articles, pre-clinical and clinical research published, written in Portuguese and English and available in complete text. The selected articles were analyzed based on the technologies covered, future perspectives, challenges, diseases mentioned and the central idea of the article. Result: 36 articles were included. Conclusion: Cholesteatoma is important in medical practice, despite being relatively uncommon in the general population. However, there are still doubts about its cause, but its diagnosis has been expanded through imaging tests in an attempt to reduce “second-look” operations and avoid them. Another field with constant growth is surgical treatment, since the complex anatomy requires that new techniques be managed to reduce injuries to important and vital structures in the region.

Introdução: O colesteatoma, embora relativamente raro, apresenta desafios significativos na prática clínica. Apesar de décadas de pesquisa, sua causa permanece complexa e evasiva. Objetivo: Esta revisão pretendeu resumir as principais descobertas sobre a epidemiologia, fisiopatologia, diagnóstico e manejo cirúrgico do colesteatoma, destacando lacunas de conhecimento atuais e tendências emergentes no campo. Método: Revisão narrativa realizada nas bases PubMed e Scielo. A busca utilizou as seguintes palavras-chave: “colesteatoma, ápice petros, procedimentos cirúrgicos minimamente invasivos” e suas versões ao inglês Os critérios de inclusão compreenderam artigos de revisão, pesquisas pré-clínicas e clínicas publicados, escritos em português e inglês e disponíveis em texto completo. Os artigos selecionados foram analisados com base nas tecnologias abordadas, perspectivas futuras, desafios, doenças referidas e ideia central do artigo. Resultado: Foram incluídos 36 artigos. Conclusão: O colesteatoma tem importância na prática médica, apesar de ser relativamente pouco frequente na população em geral. No entanto, ainda existem dúvidas sobre sua causa, mas seu diagnóstico tem sido ampliado atavés de exames de imagem na tentativa de redução das operações de “segundo-olhar”, evitando-as. Outro campo com crescimento constante é o tratamento cirúrgico, uma vez que a anatomia complexa exige que novas técnicas sejam manejadas para diminuir lesões de estruturas importantes e vitais da região.

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

ABSTRACT The objective of this work was to evaluate the application efficiency of different nozzle tips associated with increasing application rates. A field experiment was conducted in a factorial 3 × 4 randomized block design with four replicates. The first factor consisted of three types of nozzle tips (simple flat fan, hollow cone, and hollow cone with the electrification of the drops), and the second factor constituted the four application rates (50, 100, 200, and 250 L ha-1). Electrostatic technology and a hollow cone tip increased the deposited volume on leaves on the upper and medium strata of the common bean plant, regardless of the application rate used. The increase in the application rate increased the volume of spray solution captured in the upper, medium, and lower strata, the drop density, the volumetric median diameter (VMD), and the percentage of foliar coverage, regardless of the spray tip evaluated. The percentage of leaf coverage on the adaxial and abaxial leaf was not influenced by the simple fan or hollow cone spray tips, with or without the association of electrostatic technology. replicates drops, drops , drops) 50, 50 (50 100 200 25 ha1. ha1 ha 1 . ha-1) plant used density VMD, VMD (VMD) evaluated 5 (5 10 20 2 ha-1 (VMD ( ha-

RESUMO O objetivo deste trabalho foi avaliar a eficiência de aplicação de diferentes pontas de bicos associada a taxas crescentes de aplicação. Foi conduzido um experimento de campo no delineamento em blocos ao acaso, em esquema fatorial 3 x 4, com quatro repetições. O primeiro fator consistiu em três tipos de bicos: leque plano simples, cone oco e cone oco com eletrificação das gotas; e o segundo fator por quatro taxas de aplicação (50, 100, 200 e 250 L ha-1). A tecnologia eletrostática e o cone oco aumentaram o volume depositado nas folhas dos estratos superior e médio do feijoeiro, independentemente da dose de aplicação utilizada. O aumento da taxa de aplicação aumentou o volume de calda captado nos estratos superior, médio e inferior do feijoeiro, a densidade de gotas, o diâmetro médio volumétrico (DMV) e a porcentagem de cobertura foliar, independente da ponta de pulverização avaliada. A porcentagem de cobertura foliar na face adaxial e abaxial não foi influenciada pelas pontas de pulverização em leque simples e cone oco com ou sem a associação da tecnologia eletrostática. acaso 4 repetições gotas 50, 50 (50 100 20 25 ha1. ha1 ha 1 . ha-1) feijoeiro utilizada DMV (DMV avaliada 5 (5 10 2 ha-1 ( ha-

ABSTRACT Tamarind (Tamarindus indica L.) is a species with promising potential for commercial production; therefore, studies involving practices of conducting culture in the initial stage are essential. The present study aimed to evaluate different shading levels and substrate compositions in the seedling production of tamarind. The experimental design was completely randomized in a 4×4 factorial scheme, four levels of shading (0%, 18%, 30%, and 50%) and four substrates (pine bark-based substrate pure and mixed with 50% vermiculite, and sphagnum peat-based substrate pure and mixed with 50% vermiculite), with four replicates of four seedlings. Growth and biometric relationships were evaluated at 40 and 98 d after transplantation (DAT). The results reported that seedlings formed on the sphagnum peat-based substrate on pure or associated with vermiculite at 98 DAT had a height greater than 35 cm and a total 8.5 g DM. In contrast, seedlings produced in pine bark-based substrate did not reach 20 cm in height and had less than 3 g total DM. The condition of 30% and 50% shading promoted greater growth in height, reaching an average height greater than 40 cm, while in the full sun environment, seedlings showed an average of less than 35 cm; however, for the other variables, full sun environment did not differ from 30% shading, producing good quality seedlings. Thus, the cultivation of seedlings in an environment with 0% or 30% shading, associated with the sphagnum peat-based substrate pure or mixed with 50% vermiculite promoted the production of tamarind seedlings with vigorous growth. In the best environments, the best substrates increased, on average, 41.3% number of leaves, 80.5% shoot dry mass, 56.8% root dry mass, and 71.0% total dry mass. In the best substrates, the best environments increased, on average, 18.0% number of leaves, 20.7% shoot dry mass, 8.7% root dry mass, and 14.3% total dry mass.

ABSTRACT: The cheese after processing, generates whey, which is a residue that has potential benefit to human health. However, there are still few studies that seek to evaluate the composition and potential benefits of goat milk whey, even though it is a promising dairy source. Despite this, the large-scale generation of this waste can favor the environmental impact when improperly disposed of. Given this, the use of all content of dairy production can reverse this impact and increase the income of the dairy industry. Thus, this research prepared a powdered product based on goat’s milk whey from the spray drying technique and evaluate its physicochemical composition by chemical analytical methods and protein profile through polyacrylamide gel electrophoresis. The elaborated product had a higher carbohydrate content than protein, and the identification of protein fractions showed that the most expressive bands represented beta-lactoglobulin and alpha-lactoalbumin. Therefore, the elaborated product has the potential to generate novel products for human consumption and with potential health benefits. ABSTRACT processing However source largescale large scale industry Thus goats s electrophoresis betalactoglobulin beta lactoglobulin alphalactoalbumin. alphalactoalbumin alpha lactoalbumin. lactoalbumin alpha-lactoalbumin Therefore

RESUMO: O queijo após processado gera o soro de leite, sendo este um resíduo que possui potencial benefício à saúde humana. No entanto, ainda são poucos os estudos que buscam avaliar a composição e os potenciais benefícios do soro de leite de cabra, mesmo esta sendo uma fonte láctea promissora. Apesar disso, a geração em larga escala deste resíduo pode favorecer o impacto ambiental quando descartado inadequadamente. Em vista disso, a utilização de todo conteúdo gerado na produção de lácteos pode reverter este impacto e aumentar o rendimento da indústria de laticínios. Diante disso, é importante buscar o desenvolvimento de novos produtos para favorecer a redução do impacto gerado. Assim, este trabalho teve como objetivo elaborar um produto em pó, à base de soro de leite de cabra a partir da secagem pela técnica de spray drying e avaliar sua composição físico-química por métodos químicos analíticos e perfil proteico através da eletroforese em gel de poliacrilamida. O produto elaborado apresentou maior teor de carboidratos do que proteína, e a identificação das frações proteicas mostrou que as bandas mais expressivas representavam beta-lactoglobulina e alfa-lactoalbumina. Portanto, o produto elaborado apresenta potencial para geração de novos produtos para consumo humano e com prováveis benefícios à saúde. RESUMO humana entanto promissora disso inadequadamente laticínios Assim pó físicoquímica físico química poliacrilamida proteína betalactoglobulina beta lactoglobulina alfalactoalbumina. alfalactoalbumina alfa lactoalbumina. lactoalbumina alfa-lactoalbumina Portanto

ABSTRACT BACKGROUND: Abnormal uterine bleeding (AUB) is a common condition, and the Menstrual Bleeding Questionnaire (MBQ) is used for its assessment. OBJECTIVES: To translate, assess the cut-off point for diagnosis, and explore psychometric properties of the MBQ for use in Brazilian Portuguese. DESIGN AND SETTING: Prospective cohort study including 200 women (100 with and 100 without AUB) at a tertiary referral center. METHODS: MBQ translation involved a pilot-testing phase, instrument adjustment, data collection, and back-translation. Cut-off point was obtained using receiver operating curve analysis. Menstrual patterns, impact on quality of life due to AUB, internal consistency, test-retest, responsiveness, and discriminant validity were assessed. For construct validity, the Pictorial Blood Assessment Chart (PBAC) and World Health Organization Quality of Life – abbreviated version (WHOQOL-BREF) were applied. RESULTS: Women with AUB were older, had higher body mass indices, and had a worse quality of life during menstruation. Regarding the MBQ's psychometric variables, Cronbach's alpha coefficient was > 0.70 in all analyses, high intraclass correlation coefficient was found in both groups; no ceiling and floor effects were observed, and construct validity was demonstrated (correlation between MBQ score, PBAC score, and clinical menstrual cycle data). No difference between MBQ and PBAC scores were perceived after the test-retest. Significant differences were found between MBQ and PBAC scores before and after treatment. An MBQ score ≥ 24 was associated with a high probability of AUB; accuracy of 98%. CONCLUSION: The MBQ is a reliable questionnaire for Brazilian women. The cut-off ≥ 24 shows high accuracy to discriminate AUB. BACKGROUND (AUB condition (MBQ assessment OBJECTIVES translate cutoff cut off diagnosis Portuguese SETTING 20 (10 10 center METHODS pilottesting pilot testing phase adjustment collection backtranslation. backtranslation back translation. back-translation Cutoff Cut analysis patterns consistency testretest, testretest test retest, retest test-retest responsiveness assessed (PBAC WHOQOLBREF WHOQOL BREF (WHOQOL-BREF applied RESULTS older indices menstruation MBQs s variables Cronbachs Cronbach 070 0 70 0.7 analyses groups observed data. . data) testretest. retest. treatment 2 98 98% CONCLUSION (1 1 07 7 0. 9 (

ABSTRACT Background: Microscopic colitis (MC) is a chronic inflammatory bowel disease causing non-bloody diarrhea, and several cases are undiagnosed as a hidden cause of chronic diarrhea. Objective: We aimed to report the symptoms, delay diagnosis and the treatment of MC in a case series. Methods: All patients were treated at a Gastroenterology reference office from May 2022 to June 2023. Personal history including preexisting disorders, use of medications and smoking habits were collected. The delay between the onset of symptoms and the correct diagnosis was informed. All patients consented to use budesonide MMX (Corament®) off label. Results: During the study period, six Caucasoid patients were diagnosed with MC, five females and one male, between the ages of 65 and 74. All patients had comorbities and were taking multiple prescription drugs. Laboratory findings showed negative serology for celiac disease for all patients, normal levels of albumin and vitamin B12. The delay between the symptoms and the MC diagnosis varied from 2 months to 6 years. All patients had a previous diagnosis of irritable bowel syndrome. All patients were in complete clinical remission during the treatment and referred no side effects of the drug. Conclusion: Older females using high-risk medications are suggestive of MC. Preventing delay in the diagnosis of MC is crucial to improvement in patients´ quality of life. Budesonide MMX appears to be effective, safe and well-tolerated. Background (MC nonbloody non bloody diarrhea Objective series Methods 202 2023 disorders collected informed Corament® Corament (Corament® label Results period male 74 drugs B12 B years syndrome drug Conclusion highrisk high risk life effective welltolerated. welltolerated well tolerated. tolerated well-tolerated 20 (Corament 7 B1

RESUMO Contexto: A colite microscópica (CM) é uma doença inflamatória intestinal crônica que causa diarreia não sanguinolenta, e vários casos não são diagnosticados como uma causa oculta de diarreia crônica. Objetivo: Esse estudo visou relatar os sintomas, qual o atraso diagnóstico e o tratamento da CM em uma série de casos. Métodos: Todos os pacientes foram atendidos em um consultório de referência em Gastroenterologia no período de maio de 2022 a junho de 2023. Foram coletados antecedentes pessoais, incluindo distúrbios preexistentes, uso de medicamentos e tabagismo. Foi buscado o período entre o início dos sintomas e o diagnóstico correto. Todos os pacientes consentiram em usar budesonida MMX (Corament®) off label. Resultados: Durante o período do estudo, seis pacientes caucasóides foram diagnosticados com CM, cinco mulheres e um homem, com idades entre 65 e 74 anos. Todos os pacientes apresentavam comorbidades e faziam uso de vários medicamentos prescritos. Os achados laboratoriais mostraram sorologia negativa para doença celíaca em todos os pacientes, níveis normais de albumina e vitamina B12. O atraso entre os sintomas e o diagnóstico de CM variou de 2 meses a 6 anos. Todos os pacientes tinham diagnóstico prévio de síndrome do intestino irritável. Todos os pacientes apresentaram remissão clínica completa durante o tratamento e não referiram efeitos colaterais da droga. Conclusão: As mulheres mais velhas que usam medicamentos de alto risco são sugestivas de CM. Evitar o atraso no diagnóstico de CM é fundamental para melhorar a qualidade de vida dos pacientes. A budesonida MMX foi eficaz, segura e bem tolerada. Contexto (CM sanguinolenta Objetivo Métodos 202 2023 pessoais preexistentes tabagismo correto Corament® Corament (Corament® label Resultados homem 7 anos prescritos B12 B irritável droga Conclusão eficaz tolerada 20 (Corament B1

Abstract Recent studies have suggested that therapies with stem cells and amniotic membrane can modulate the inflammation following an ischemic injury in the heart. This study evaluated the effects of bone-marrow mononuclear cells (BMMC) and acellular human amniotic membrane (AHAM) on cardiac function and NLRP3 complex in a rat model of heart failure.On the 30th day,the echocardiographic showed improvements on ejection fraction and decreased pathological ventricular remodeling on BMMC and AHAM groups.Oxidative stress analysis was similar between the three groups,and the NLRP3 inflammasome activity were not decreased with the therapeutic use of both BMMC and AHAM,in comparison to the control group. bonemarrow bone marrow (BMMC (AHAM NLRP failureOn failure On th daythe day groupsOxidative groups Oxidative groupsand AHAMin group

Abstract: The aim was to evaluate primary implant stability and bone microarchitecture in two drilling situations, by comparing the conventional technique (CT) and osseodensification (OD) (Versah Burs - Jackson - Mississippi - USA). The implant insertion torque (IT), implant stability quotient (ISQ), and the peri-implant trabecular microstructure were assessed on bone fragments obtained from pig’s tibia (n=12), divided between CT (n=6) and OD (n=6). After the drilling procedure, the implants were installed (3.5x8.5 mm, Epikut - SIN - São Paulo - Brazil). The IT and ISQ were measured using a digital torque wrench and resonance frequency analysis. Then, the bone fragments containing the implants were removed with a trephine and analyzed by Microtomography (µCT, 8.0 µm). The comparison between groups was performed using the unpaired t-test (α=0.05). The results revealed that OD promotes a higher insertion torque (CT: 7.67±2.44 Ncm; OD: 19.78±5.26 Ncm) (p=0.0005), although ISQ was not different (CT: 61.33±4.66; OD: 63.25±4.58) (p=0.48). There was a significant increase in peri-implant bone volume (CT: 23.17±3.39 mm3; OD: 32.01±5.75 mm3) (p=0.008), and trabecular parameters: separation (CT: 0.4357±0.03 mm; OD: 0.3865±0.04 mm) (p=0.0449), number (CT: 1.626±0.18 1/mm; OD: 1.946±0.13 1/mm) (p=0.007), and thickness (CT: 0.1130±0.009 mm; OD: 0.1328±0.015 mm) (p=0.02). Structure model index (SMI) data demonstrate no significant differences between groups (CT: 1.7±0.2; OD: 1.4±0.4) (p=0.12). In conclusion, OD increases the insertion torque values and promotes beneficial changes regarding bone microarchitecture compared with CT, revealing more peri-implant bone volume with consequent higher primary stability. Abstract situations (CT (OD Versah USA. USA . USA) IT, , (IT) ISQ, (ISQ) periimplant peri pigs pig s n=12, n12 n n=12 12 (n=12) n=6 n6 6 (n=6 n=6. procedure 3.5x8.5 35x85 x 3 5x8 5 (3.5x8. mm Brazil. Brazil Brazil) analysis Then µCT, µCT (µCT 80 8 0 8. µm. µm µm) ttest t test α=0.05. α005 α α=0.05 05 (α=0.05) 767244 7 67 2 44 7.67±2.4 Ncm 1978526 19 78 26 19.78±5.2 p=0.0005, p00005 p p=0.0005 0005 (p=0.0005) 61.33±4.66 6133466 61 33 4 66 63.25±4.58 6325458 63 25 58 p=0.48. p048 p=0.48 48 (p=0.48) 2317339 23 17 39 23.17±3.3 mm3 3201575 32 01 75 32.01±5.7 p=0.008, p0008 p=0.008 008 (p=0.008) parameters 04357003 4357 03 0.4357±0.0 03865004 3865 04 0.3865±0.0 p=0.0449, p00449 p=0.0449 0449 (p=0.0449) 1626018 1 626 18 1.626±0.1 1/mm 1mm 1946013 946 13 1.946±0.1 p=0.007, p0007 p=0.007 007 (p=0.007) 011300009 1130 009 0.1130±0.00 013280015 1328 015 0.1328±0.01 p=0.02. p002 p=0.02 02 (p=0.02) SMI (SMI 1.7±0.2 1702 1.4±0.4 1404 p=0.12. p012 p=0.12 (p=0.12) conclusion (IT (ISQ n1 n=1 (n=12 n= (n= 3.5x8. 35x8 5x (3.5x8 α00 α=0.0 (α=0.05 76724 7.67±2. 197852 19.78±5. p0000 p=0.000 000 (p=0.0005 61.33±4.6 613346 63.25±4.5 632545 p04 p=0.4 (p=0.48 231733 23.17±3. 320157 32.01±5. p000 p=0.00 00 (p=0.008 0435700 435 0.4357±0. 0386500 386 0.3865±0. p0044 p=0.044 044 (p=0.0449 162601 62 1.626±0. 194601 94 1.946±0. (p=0.007 01130000 113 0.1130±0.0 01328001 132 0.1328±0.0 p00 p=0.0 (p=0.02 1.7±0. 170 1.4±0. 140 p01 p=0.1 (p=0.12 (n=1 (n 3.5x8 35x (3.5x α0 α=0. (α=0.0 7672 7.67±2 19785 19.78±5 (p=0.000 61.33±4. 61334 63.25±4. 63254 p0 p=0. (p=0.4 23173 23.17±3 32015 32.01±5 (p=0.00 043570 43 0.4357±0 038650 38 0.3865±0 p004 p=0.04 (p=0.044 16260 1.626±0 19460 9 1.946±0 0113000 11 0.1130±0. 0132800 0.1328±0. (p=0.0 1.7±0 1.4±0 14 (p=0.1 3.5x α=0 (α=0. 767 7.67± 1978 19.78± 61.33±4 6133 63.25±4 6325 p=0 (p=0. 2317 23.17± 3201 32.01± 04357 0.4357± 03865 0.3865± (p=0.04 1626 1.626± 1946 1.946± 011300 0.1130±0 013280 0.1328±0 1.7± 1.4± α= (α=0 76 7.67 197 19.78 61.33± 613 63.25± 632 p= (p=0 231 23.17 320 32.01 0435 0.4357 0386 0.3865 162 1.626 194 1.946 01130 0.1130± 01328 0.1328± 1.7 1.4 (α= 7.6 19.7 61.33 63.25 (p= 23.1 32.0 043 0.435 038 0.386 16 1.62 1.94 0113 0.1130 0132 0.1328 1. (α 7. 19. 61.3 63.2 (p 23. 32. 0.43 0.38 1.6 1.9 011 0.113 013 0.132 61. 63. 0.4 0.3 0.11 0.13 0. 0.1

Resumo O objetivo deste estudo foi avaliar a estabilidade de implante e a microarquitetura óssea em duas técnicas de fresagem, comparando a técnica convencional (CT) e a osseodensificação (OD) (Versah Burs - Jackson - Mississippi - EUA). O torque de inserção do implante (IT), quociente de estabilidade primária (ISQ) e a estrutura trabecular peri-implantar foram avaliados em fragmentos ósseos obtidos de tíbia de porco (n=12), divididos entre CT (n=6) e OD (n=6). Após o procedimento de fresagem, foram instalados implantes (3,5x8,5 mm, Epikut - SIN - São Paulo - Brasil). O IT e o ISQ foram aferidos por meio de um torquimetro digital e análise de frequência de ressonância. Em seguida, os fragmentos ósseos contendo os implantes foram removidos com trefina e analisados por microtomografia computadorizada (µCT, 8,0 µm). A comparação entre os grupos foi realizada por meio do teste-t não-pareado (α=0.05). Os resultados revelaram que a OD promove maior torque de inserção (CT: 7,67 ± 2,44º Ncm; OD: 19,78 ± 5,26 Ncm) (p=0,0005), embora a estabilidade primária não tenha sido diferente (CT: 61.33 ± 4.66; OD:63.25 ± 4.58) (p=0,48). Houve um aumento significativo no volume ósseo peri-implantar (CT: 23,17±3,39 mm3; OD: 32,01±5,75 mm3) (p=0,0089) e parâmetros trabeculares: separação (CT: 0,4357 ± 0,03 mm; OD: 0,3865 ± 0,04 mm) (p=0,0449), número (CT: 1,626 ± 0,18 1/mm; OD: 1,946 ± 0,13 1/mm) (p=0,007) e espessura (CT: 0,1130 ± 0,009 mm; OD: 0,1328 ± 0,015 mm) (p=0,02) O índice de modelo estrutural (SMI) não demostrou diferença estatisticamente significativa (p=0.1228). Concluindo, OD apresenta maiores valores de torque de inserção e promove mudanças benéficas na microarquitetura óssea em comparação com a TC, revelando maior volume ósseo peri-implantar. fresagem (CT (OD Versah EUA. EUA . EUA) IT, , (IT) (ISQ periimplantar peri implantar n=12, n12 n n=12 12 (n=12) n=6 n6 6 (n=6 n=6. 3,5x8,5 35x85 x 3 5x8 5 (3,5x8, mm Brasil. Brasil Brasil) ressonância seguida µCT, µCT (µCT 80 8 0 8, µm. µm µm) testet teste t nãopareado pareado α=0.05. α005 α α=0.05 05 (α=0.05) 767 7 67 7,6 244º º 2 44º Ncm 1978 19 78 19,7 526 26 5,2 p=0,0005, p00005 p p=0,0005 0005 (p=0,0005) 6133 61 33 61.3 4.66 466 4 66 OD63.25 OD6325 63.25 63 25 OD:63.2 4.58 458 58 p=0,48. p048 p=0,48 48 (p=0,48) 2317339 23 17 39 23,17±3,3 mm3 3201575 32 01 75 32,01±5,7 p=0,0089 p00089 0089 (p=0,0089 trabeculares 04357 4357 0,435 003 03 0,0 03865 3865 0,386 004 04 p=0,0449, p00449 p=0,0449 0449 (p=0,0449) 1626 1 626 1,62 018 18 0,1 1/mm 1mm 1946 946 1,94 013 13 p=0,007 p0007 007 (p=0,007 01130 1130 0,113 0009 009 0,00 01328 1328 0,132 0015 015 0,01 p=0,02 p002 02 (p=0,02 SMI (SMI p=0.1228. p01228 p=0.1228 1228 (p=0.1228) Concluindo TC periimplantar. implantar. (IT n1 n=1 (n=12 n= (n= 3,5x8, 35x8 5x (3,5x8 α00 α=0.0 (α=0.05 76 7, 197 19, 52 5, p0000 p=0,000 000 (p=0,0005 613 61. 4.6 46 OD63 OD63.2 OD632 6325 63.2 OD:63. 4.5 45 p04 p=0,4 (p=0,48 231733 23,17±3, 320157 32,01±5, p=0,008 p0008 008 (p=0,008 0435 435 0,43 00 0, 0386 386 0,38 p0044 p=0,044 044 (p=0,0449 162 62 1,6 194 94 1,9 p=0,00 p000 (p=0,00 0113 113 0,11 0132 132 001 p=0,0 p00 (p=0,0 p0122 p=0.122 122 (p=0.1228 (n=1 (n 3,5x8 35x (3,5x α0 α=0. (α=0.0 (p=0,000 4. OD6 OD63. 632 63. OD:63 p0 p=0, (p=0,4 23173 23,17±3 32015 32,01±5 043 43 0,4 038 38 0,3 p004 p=0,04 (p=0,044 16 1, 9 011 11 (p=0, p012 p=0.12 (p=0.122 3,5x α=0 (α=0. OD:6 p=0 2317 23,17± 3201 32,01± (p=0,04 (p=0 p01 p=0.1 (p=0.12 α= (α=0 p= 231 23,17 320 32,01 (p= p=0. (p=0.1 (α= 23,1 32,0 (p (p=0. (α 23, 32,

Abstract Paper aims This study aims to identify the advances in the literature related to Sustainable Life Cycle Assessment in the agricultural and food process sectors. Originality This study pioneers an investigation into trends in applying Life Cycle Sustainability Assessment techniques within the agricultural and food processing sectors, with a comprehensive consideration of environmental, economic, and social perspectives. Research method A systematic literature review and a bibliometric analysis revealed 71 articles that applied at least one of the life cycle assessment tools. Main findings The bibliometric analysis indicated that the studied areas have two main areas that separate studies in the food process sector and the agricultural sector areas. The content analysis indicated that most studies apply the environmental assessment of the life cycle, coupling some studies with the economic and social view and mainly using an attributional approach with the scope ranging from the cradle to the grave regarding the area. Implications for theory and practice As for theory, this study includes advancing knowledge and filling a research gap, while the practical relates to more sustainable decision-making by professionals involved in the agricultural and food processing sectors. sectors perspectives 7 tools area gap decisionmaking decision making

ABSTRACT: Plant selection conducted in commercial orchards is mainly based on plant features. This study characterizes and selects acerola tree genotypes with promising features for cultivation in the Gurguéia Valley region, Piauí. Twenty-five genotypes were used, consisting of 15 clones (CL 03, CL 08, CL 09, CL 12, CL 13, CL 14, CL 20, CL 23, CL 26, CL 27, CL 30, CL 31, CL 33, CL 36, and CL 38) and 10 cultivars (BRS 235, BRS 236, BRS 237, BRS 238, BRS 366, Sertaneja, Costa Rita, Morena, Tropicana, and Junko). The experiment was set up in a randomized block design with three blocks and three plants per experimental unit in 4 m x 3 m spacing. A total of 40% of the genotypes evaluated showed an umbrella shape, 36% showed a semi-open shape, and 24% showed an open shape. Clones 09, 14, and 12 presented the highest cultivation potential in the region, with monthly production of 5.01, 4.30, and 3.70 kg plant-¹ per year and productivity of 4.16, 3.59, and 3. 08-ton ha-¹, respectively. Clone 27, cultivars BRS 236 and BRS 235, and clone 14 were the earliest genotypes, requiring 1,503.3, 1,535.6, 1,686.6, and 1,686.6 DD; respectively, to complete their cycle. Clones 09 and 14 stood out from the others and are potentially promising for cultivation in the Gurgueia Valley region. ABSTRACT region Piauí Twentyfive Twenty five used 1 03 08 13 20 23 26 27 30 31 33 36 38 235 237 238 366 Sertaneja Rita Morena Tropicana Junko. Junko . Junko) spacing 40 shape semiopen semi 24 501 5 01 5.01 430 4.30 370 70 3.7 plant¹ ¹ plant- 416 16 4.16 359 59 3.59 08ton ton ha¹, ha¹ ha ¹, ha-¹ respectively 15033 503 1,503.3 15356 535 6 1,535.6 16866 686 1,686. DD cycle 0 2 50 5.0 43 4.3 37 7 41 4.1 35 3.5 ha- 1503 1,503. 1535 53 1,535. 1686 68 1,686 5. 4. 150 1,503 153 1,535 168 1,68 1,50 1,53 1,6 1,5 1,

RESUMO: A seleção de plantas conduzida em pomares comerciais é baseada principalmente nas características da planta. Este trabalho teve como objetivo caracterizar e selecionar genótipos de aceroleira com características promissoras para cultivo na região do Vale do Gurguéia, Piauí. Foram utilizados 25 genótipos, sendo 15 clones (CL 03, CL 08, CL 09, CL 12, CL 13, CL 14, CL 20, CL 23, CL 26, CL 27, CL 30, CL 31, CL 33, CL 36 e CL 38) e 10 cultivares (BRS 235, BRS 236, BRS 237, BRS 238, BRS 366, Sertaneja, Costa Rita, Morena, Tropicana e Junko). O experimento foi instalado no delineamento de blocos casualizados com três blocos e três plantas por unidade experimental no espaçamento de 4 m x 3 m. Um total de 40% dos genótipos avaliados apresentou formato guarda-chuva, 36% formato semiaberto e 24% formato aberto. Os clones 09, 14 e 12 apresentaram o maior potencial de cultivo da região, com produção mensal de 5,01, 4,30 e 3,70 kg planta-¹ por ano e produtividade de 4,16, 3,59 e 3,08 ton ha-¹, respectivamente. O clone 27, as cultivares BRS 236 e BRS 235 e o clone 14 foram os genótipos mais precoces, requerendo 1.503,3, 1.535,6, 1.686,6 e 1.686,6 DD, respectivamente, para completar seu ciclo. Os clones 09 e 14 se destacaram em relação aos demais e são potencialmente promissores para cultivo na região do Vale do Gurgueia. RESUMO planta Gurguéia Piauí 2 1 03 08 13 20 23 26 27 30 31 33 38 237 238 366 Sertaneja Rita Morena Junko. Junko . Junko) 40 guardachuva, guardachuva guarda chuva, chuva guarda-chuva 24 aberto 501 5 01 5,01 430 4,3 370 70 3,7 planta¹ ¹ planta- 416 16 4,16 359 59 3,5 308 3,0 ha¹, ha¹ ha ¹, ha-¹ respectivamente precoces 15033 503 1.503,3 15356 535 6 1.535,6 16866 686 1.686, DD ciclo 0 Gurgueia 50 5,0 43 4, 37 7 3, 41 4,1 35 ha- 1503 1.503, 1535 53 1.535, 1686 68 1.686 5, 150 1.503 153 1.535 168 1.68 1.50 1.53 1.6 1.5 1.

ABSTRACT Objective: To evaluate the efficacy and safety of sliding osteotomy of the lateral epicondyle in correcting rigid valgus deformity in knee arthroplasty. Methods: A retrospective study of patients undergoing total knee arthroplasty with lateral epicondyle sliding osteotomy between 2006 and 2018. The main outcome was the incidence of complications and adverse events. Secondary outcomes were Visual Analog Scale for Pain, varus stress test, and varus knee thrust during gait. Results: 19 knees (19 participants) were included in the study. The mean follow-up was 4.2 years. There were no cases of infection or reoperation due to instability. Two participants (10.5%) had mild or moderate knee pain (VAS pain = 4.6 ± 1.9). Two arthroplasties (10.5%) had mild varus stress. No participant presented varus thrust. Conclusion: Sliding osteotomy of the lateral epicondyle allows fast and safe ligament balance of knee valgus deformities. Level of Evidence I, Case series. Objective Methods 200 2018 events Pain test gait Results 1 (1 followup follow up 42 4 2 4. years instability 10.5% 105 10 5 (10.5% VAS 46 6 1.9. 1.9 . 9 1.9) Conclusion deformities I series 20 201 ( 10.5 (10.5 1. 10. (10. (10

RESUMO Avaliar a eficácia e a segurança da osteotomia de deslizamento do epicôndilo lateral na correção da deformidade em valgo rígida na artroplastia de joelho. Métodos: Estudo retrospectivo de pacientes submetidos à artroplastia total do joelho com osteotomia de deslizamento do epicôndilo lateral entre 2006 e 2018. O principal desfecho foi a incidência de complicações e eventos adversos. Os desfechos secundários foram escala visual analógica para dor, teste de estresse em varo e flambagem em varo do joelho durante a marcha. Resultados: Foram incluídos no estudo 19 joelhos (19 participantes). O seguimento médio foi de 4,2 anos. Não houve nenhum caso de infecção ou reoperação devido à instabilidade. Dois participantes (10,5%) apresentaram algum tipo de dor leve ou moderada no joelho (EVA = 4,6 ± 1,9). Duas artroplastias (10,5%) apresentaram estresse em varo leve. Nenhum participante apresentou flambagem em varo. Conclusão: A osteotomia de deslizamento do epicôndilo lateral possibilitou o balanço ligamentar das deformidades em valgo do joelho de forma rápida e segura. Nível de Evidência IV, Série de Casos. Métodos 200 2018 adversos marcha Resultados 1 (1 participantes. . participantes) 42 4 2 4, anos instabilidade 10,5% 105 10 5 (10,5% EVA 46 6 1,9. 1,9 9 1,9) Conclusão segura IV Casos 20 201 ( 10,5 (10,5 1, 10, (10, (10

Cancer is one of the major causes of death worldwide, and breast cancer is the most prevalent and deadly type among women. Despite the side effects and the phenomena of chemoresistance associated with the drugs involved, chemotherapy remains the main therapeutic strategy to combat and control breast cancer. Therefore, several new classes of compounds against breast cancer have been explored, in an effort to identify new drug candidates with alternative mechanisms of action. The principal results of such exploration, focusing on caged xanthones, thiosemicarbazones and photosensitizers, are presented in this review, along with the main aspects of the drug discovery process against breast cancer. More specifically, the design, structure-activity relationship investigations and anti-breast cancer properties of these three classes are described and discussed in this work. worldwide women involved Therefore explored action exploration xanthones photosensitizers review specifically design structureactivity structure activity antibreast anti work

ABSTRACT This work presents an integrated decision support process based on Value-Focused Thinking (VFT) applicable to personal and organizational decisions. There are three main goals of this research: (i) present a methodological discussion on Value-Focused Thinking (VFT) and depict how it can contribute to support decision processes; (ii) present an integrated guide for a decision-support process based on VFT to help analysts and decision-makers in conducting decision processes; (iii) present applications of the proposed approach in a personal and a public management problem. This work delivers two main contributions: (a) a unified process that integrates different approaches based on VFT with a consistent structure for sequencing the stages of the decision-making process; and (b) examples that demonstrate the use of the proposed process in real problems and different contexts, presenting insights not thoroughly explored in the literature. ValueFocused Value Focused (VFT decisions research i (i processes ii (ii decisionsupport decisionmakers makers iii (iii problem contributions (a decisionmaking making b (b contexts literature