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[SciELO Preprints] - Challenges and Lessons from the COVID-19 Pandemic for Health Surveillance in Brazil: Reflections on Technologies, Models, and System Organization
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Henriques, Claudio Maierovitch Pessanha Moura, Noely Fabiana Oliveira de Souza, Priscila Bochi de

Métricas do periódico
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Data de publicação: 2024-09-30

Resumo: Pt En

A vigilância em saúde, como vigilância de agravos e doenças, tem um escopo bastante amplo. Discutiremos aqui a face mais conhecida, que é a vigilância de doenças transmissíveis, e assumiremos como mote a pandemia causada pelo vírus SARS-CoV-2. No desenvolvimento do texto, a abordagem se amplia para uma reflexão sobre tecnologias, modelo e organização do sistema. A mais grave epidemia de nossa época, classificada como pandemia, por atingir simultaneamente todo o planeta, tem obrigado a reflexões que envolvem múltiplos campos do conhecimento. O sofrimento decorrente deve inibir a tentação de associá-la a qualquer imagem positiva, ainda que tenha havido oportunidade para aprender e, em algumas circunstâncias, testemunhar a capacidade humana de agir solidariamente. Poucas coisas são tão didáticas como tragédias e erros. Cabe explorá-los cuidadosamente e extrair a necessária retroalimentação para corrigir rumos da atuação em saúde. Neste texto, trataremos das condições que levaram a vigilância em saúde no Brasil a falhar fragorosamente em sua missão frente à emergência desencadeada pela doença do novo coronavírus 2019 e levantaremos pontos que merecem atenção em uma reestruturação do sistema de vigilância em saúde.

The term "health surveillance" encompasses a wide range of activities, including the monitoring and observation of illnesses and diseases. In this section, we will examine the most well-known aspect of health surveillance, namely the monitoring of communicable diseases. To illustrate our discussion, we will use the ongoing pandemic caused by the SARS-CoV-2 virus as a case study. As the text progresses, the focus shifts to an examination of technologies, models, and the structure of the system. The most severe epidemic of our era, classified as a pandemic due to its global impact, has compelled us to reflect on a multitude of disciplines. The resulting suffering should preclude any association with positive images, despite the opportunity to learn and, in some instances, observe the capacity of humans to act in solidarity. It is often observed that few things are as didactic as tragedies and mistakes. It is therefore important to explore them carefully to extract the necessary feedback to correct the course of action in health. In this text, we will discuss the conditions that led health surveillance in Brazil to fail miserably in its mission in the face of the emergency triggered by the novel coronavirus disease 2019. We will also present points that deserve attention in a restructuring of the health surveillance system.

https://doi.org/10.1590/1980-549720240049.2

[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

Métricas do periódico
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Data de publicação: 2024-04-08

Resumo: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

Subjetivação e riscos psicossociais da uberização do trabalho nas dinâmicas territoriais
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Gomes-Souza, Ronaldo

; Tramontano, Marcelo Claudio

Cadernos Metrópole

Métricas do periódico
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Jan 2024, Volume 26 Nº 59 Páginas 143 - 167

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract In view of the economic, political, and technological changes in the world of work within the urban territory, nowadays we are facing new informalities that increase the precariousness of work relationships and conditions in a global level. This essay aims to reflect critically on new subjectivations and on psychosocial risks related to the uberization of work, analyzing their impacts on territorial dynamics. We highlight platform companies that offer taxi and delivery services, and we provide a panorama that shifts from the international to the national scenario. Uberized workers face unique episodes of violence committed by platform companies and urban violence, which intensify psychosocial risks and harm workers' dignity, health, and quality of life. The practices of platform companies, as well as their management and contradictions, reveal a deprivation of the right to the city and the capture of workers' subjectivity. economic political territory level dynamics services scenario dignity health life contradictions subjectivity

Resumo Diante das mudanças econômicas, políticas e tecnológicas do mundo do trabalho no território urbano, enfrentamos hoje novas informalidades que precarizam as relações e condições de trabalho de forma global. O objetivo deste ensaio é tecer reflexões críticas sobre os processos de novas subjetivações e riscos psicossociais da uberização do trabalho e seus impactos nas dinâmicas territoriais, destacando as empresas-plataforma que oferecem serviços de táxi e entrega, fazendo um panorama que desloca do cenário internacional para o nacional. Os trabalhadores uberizados enfrentam situações singulares de violências das empresas-plataforma e urbana, agravando os riscos psicossociais, a dignidade, a saúde e a qualidade de vida dos trabalhadores. As práticas, gestão e contradições dessas empresas denotam a privação do direito à cidade e a captura da subjetividade dos trabalhadores. econômicas urbano global territoriais empresasplataforma plataforma entrega nacional urbana dignidade práticas

https://doi.org/10.1590/2236-9996.2024-5907

Psychometric properties and reliability of the Brazilian version of Parent Attitudes about Childhood Vaccine (PACV-BR) PACVBR PACV BR (PACV-BR
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Santos Júnior, Claudio José dos

; Silva, Maria Rosa da

; Costa, Paulo José Medeiros de Souza

Revista Paulista de Pediatria

Métricas do periódico
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2024, Volume 42 elocation e2023019

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To evaluate the psychometric properties and reliability of the Brazilian version of the tool Parent Attitudes about Childhood Vaccine (PACV-BR). Methods: The sample included 110 parents of children up to two years old served by Family Health Basic Units. The tool's internal consistency and factor validity were respectively assessed by Cronbach's alpha and exploratory factor analysis (EFA). The test-retest reliability was assessed by the intraclass correlation coefficient (ICC). Results: The EFA results indicated a proper structural adequacy of the PACV-BR (15 items and two factors). The reliability generated Cronbach's alpha values between 0.715 and 0.854 for the items, of 0.918 for the tool as a whole, of 0.877 for factor 1 and of 0.825 for factor 2, in addition to an ICC of 0.984. Conclusions: The PACV-BR showed evidence of construct validity and reliability. Objective PACVBR. PACVBR PACV BR . (PACV-BR) Methods 11 Units tools s Cronbachs Cronbach EFA. (EFA) testretest test retest ICC. (ICC) Results 15 (1 factors. factors factors) 0715 0 715 0.71 0854 854 0.85 0918 918 0.91 whole 0877 877 0.87 0825 825 0.82 2 0984 984 0.984 Conclusions (PACV-BR (EFA (ICC ( 071 71 0.7 085 85 0.8 091 91 0.9 087 87 082 82 098 98 0.98 07 7 0. 08 8 09 9

RESUMO Objetivo: Avaliar as propriedades psicométricas e a confiabilidade da versão brasileira do instrumento Parent Attitudes about Childhood Vaccine (PACV-BR). Métodos: A amostra incluiu 110 pais de crianças de até dois anos atendidas em Unidades Básicas de Saúde da Família. A consistência interna e a validade fatorial do instrumento foram avaliadas, respectivamente, pelo alfa de Cronbach e pela análise fatorial exploratória (EFA). A confiabilidade teste-reteste foi avaliada pelo coeficiente de correlação intraclasse (ICC). Resultados: Os resultados da AFE indicaram adequação estrutural do PACV-BR (15 itens e dois fatores). A confiabilidade indicou valores de alfa de Cronbach entre 0,715 e 0,854 para os itens, de 0,918 para o instrumento como um todo, de 0,877 para o fator 1 e de 0,825 para o fator 2, além de ICC de 0,984. Conclusões: O PACV-BR apresentou evidências de validade de construto e confiabilidade. Objetivo PACVBR. PACVBR PACV BR . (PACV-BR) Métodos 11 Família avaliadas respectivamente EFA. EFA (EFA) testereteste teste reteste ICC. (ICC) Resultados 15 (1 fatores. fatores fatores) 0715 0 715 0,71 0854 854 0,85 0918 918 0,91 todo 0877 877 0,87 0825 825 0,82 2 0984 984 0,984 Conclusões (PACV-BR (EFA (ICC ( 071 71 0,7 085 85 0,8 091 91 0,9 087 87 082 82 098 98 0,98 07 7 0, 08 8 09 9

https://doi.org/10.1590/1984-0462/2024/42/2023019

Effect of Dioscorea villosa extract and the phytoestrogen diosgenin on ovariectomized mice with zymosan-induced arthritis zymosaninduced zymosan induced
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Silva, Luiz André Santos

; Araújo, Jéssica Maria Dantas

; Almeida, Damião Rabelo de

; Araújo, Luiz Felipe Lobo Mascarenhas Fratel de

; Souza, Eloísa Portugal Barros Silva Soares de

; Matos, Saulo Santos

; Lima, Cláudio Moreira de

; Araújo, Adriano Antunes de Souza

; Camargo, Enilton Aparecido

; Grespan, Renata

Brazilian Journal of Pharmaceutical Sciences

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2024, Volume 60 elocation e23203

Resumo: En | Texto: En | PDF: En

Abstract Humans are exposed to natural compounds such as phytoestrogens primarily through diet and supplements. These compounds promote health by alleviating the symptoms and illnesses associated with menopause and arthritis. Diosgenin (DSG) occurs naturally in plants such as Dioscorea villosa (DV) and binds to estrogen receptors, so it may have similar effects to this hormone, including against arthritis. Thus, we investigated the effect of chronic treatment with dry extract of DV and its phytoestrogen DSG on ovariectomized mice with arthritis. We found that dry extract of Dioscorea villosa (DV) contains the phytoestrogen diosgenin (DSG) in its composition. Furthermore, arthritic mice treated with DV and DSG showed reduced neutrophil accumulation in the articular cartilage. Also, the dry extract of DV administered orally (v.o) did not alter the leukocyte count in the joints or promote changes in the reproductive tract. However, DSG altered these parameters, with possible beneficial effects by reducing symptoms related to reproductive aging. Thus, oral treatment with dry extract of DV and subcutaneous (s.c) treatment with DSG showed promise by acting against inflammation caused by arthritis and reducing symptoms in the reproductive tract due to menopause. supplements (DSG (DV receptors hormone Thus composition Furthermore cartilage Also v.o vo v o (v.o However parameters aging s.c sc s c (s.c

https://doi.org/10.1590/s2175-97902024e23203

Influence of cement paste thickness and volume of on pervious concrete properties
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Gentil, Fernanda dos Santos

; Ribeiro, Francisco Roger Carneiro

; Menegotto, Camila Werner

; Silva, Igor Wiscow da

; Kazmierczak, Claudio de Souza

Revista IBRACON de Estruturas e Materiais

Métricas do periódico
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2024, Volume 17 Nº 5 elocation e17509

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract This study aimed to identify the influence of replacing coarse natural aggregate with coarse recycled concrete aggregate on the thickness and volume of the cementitious paste under the variation of the water/cement ratio in the fresh and hardened properties of pervious concrete. The determined theoretical paste thickness was inefficient for pervious concrete dosage. However, it was found that the paste volume was the parameter that was best related to the mechanical and permeability properties of the studied material. Pervious concrete with natural aggregates showed higher compressive strength than concrete with recycled aggregates, although both met the regulations. All the concretes produced, except one with recycled aggregate of w/c ratio 0.25, reached the tensile strength in the minimum design bending. Pervious concrete with recycled aggregates showed more significant mass loss by abrasion and more porosity than concretes with natural aggregates. Finally, all pervious concretes presented permeability coefficients greater than the lower limit determined by the standard. watercement water cement dosage However material regulations produced wc w c 025 0 25 0.25 bending Finally standard 02 2 0.2 0.

Resumo Este estudo teve como objetivo identificar a influência da substituição do agregado graúdo natural por agregado graúdo reciclado de concreto na espessura e no volume da pasta cimentícia sob a variação da relação água/cimento nas propriedades frescas e endurecidas do concreto permeável. A espessura teórica da pasta determinada foi ineficiente para dosagem de concreto permeável. Porém, constatou-se que o volume da pasta foi o parâmetro que melhor se relacionou com as propriedades mecânicas e de permeabilidade do material estudado. O concreto permeável com agregados naturais apresentou maior resistência à compressão que o concreto com agregados reciclados, mas ambos atenderam às normas vigentes. Todos os concretos produzidos, exceto com agregado reciclado de relação a/c 0,25, atingiram a resistência à tração na flexão mínima de projeto. O concreto permeável com agregados reciclados apresentou perda de massa mais significativa por abrasão e foi mais poroso que o concreto com agregados naturais. Por fim, todos os concretos permeáveis apresentaram coeficientes de permeabilidade superiores ao limite inferior determinado pela norma. águacimento água cimento Porém constatouse constatou estudado vigentes produzidos ac c 025 0 25 0,25 projeto fim norma 02 2 0,2 0,

https://doi.org/10.1590/s1983-41952024000500009

Mycosis Fungoides: A Necessary Differential Diagnosis in Infectious Disease and Dermatology Settings Fungoides
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Santos Júnior, Claudio José dos

; Souza, Aryanna Kelly Pinheiro

; Rocha, Thiago José Matos

Revista da Sociedade Brasileira de Medicina Tropical

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2024, Volume 57 elocation e00909-2024

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/0037-8682-0622-2023

EDUCAÇÃO PÚBLICA NO ATUAL CENÁRIO SÓCIO-POLÍTICO E ECONÔMICO BRASILEIRO SÓCIOPOLÍTICO SÓCIO POLÍTICO
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Moraes, Carmen Sylvia Vidigal

; Leher, Roberto

; Ferretti, Celso João

; Amaral, Nelson Cardoso

; Ximenes, Salomão Barros

; Gomes, Nilma Lino

; Zuin, Antônio Alvaro Soares

; Almeida, Luana Costa

; Almeida, Ana Maria Fonseca de

; Trevisan, Anderson Ricardo

; Dalbosco, Claudio Almir

; Mazza, Débora

; Lima, Licínio Carlos Viana da Silva

; Goergen, Pedro

; Souza, Sandra Maria Zákia Lian

; Rambla, Xavier

; Sisto, Vicente

Educação & Sociedade

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2024, Volume 45 elocation e283572

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.1590/es.283572

Bayesian and classical approaches for the estimation of genetic parameters and coefficients of repeatability of acerola quality traits
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Vilvert, João Claudio

; Freitas, Sérgio Tonetto de

; Ferreira, Ianca Carneiro

; Ferreira, Maria Aparecida Rodrigues

; Souza, Flávio de França

; Veloso, Cristiane Martins

Acta Scientiarum. Agronomy

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2024, Volume 46 elocation e64573

Resumo: En | Texto: En | PDF: En

ABSTRACT. Although acerola (Malpighia emarginata DC.) is a tropical fruit of high interest due to its high ascorbic acid content and attractive sensory attributes, fruit production is characterized by high genetic variability. Additionally, the use of new biometric tools for acerola breeding is scarce. This study aimed to estimate genetic parameters and the coefficient of repeatability, as well as determine the optimal number of fruits for quality trait analyses in different acerola genotypes, using different approaches. Twenty-three (Experiment I) and thirty-five (Experiment II) genotypes were evaluated in a randomized block design with four replicates and three plants per plot. Twenty fruits per plant were harvested and evaluated for the following quality traits: diameter, mass, skin color (lightness, chroma and hue), firmness, soluble solids (SS), titratable acidity (TA), SS/TA ratio, and ascorbic acid content. The genetic parameters and the coefficient of repeatability were estimated for each experiment using classical and Bayesian methods. Both approaches achieved similar results on estimating variance components, genetic parameters and the coefficient of repeatability. Genetic parameters showed favorable conditions for acerola selection. The coefficient of repeatability was high for all acerola quality traits. A total of 17 fruits are required for the effective selection of acerola genotypes with an accuracy of 95%. ABSTRACT Malpighia DC. DC attributes variability Additionally scarce Twentythree Experiment I thirtyfive thirty five II plot traits diameter mass lightness, lightness (lightness hue, hue , hue) firmness SS, SS (SS) TA, TA (TA) SSTA ratio methods components 1 95 95% (SS (TA 9

https://doi.org/10.4025/actasciagron.v46i1.64573

10.

Nitrogen sources on agronomic traits in carioca common bean lines developed under mineral nitrogen fertilization
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Dias, Polianna Alves Silva

; Melo, Patrícia Guimarães Santos

; Ferreira, Enderson Petrônio de Brito

; Melo, Leonardo Cunha

; Souza, Thiago Lívio Pessoa Oliveira de

; Faria, Luís Cláudio de

; Almeida, Válter Martins de

; Pereira, Helton Santos

Bragantia

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2024, Volume 83 elocation e20230285

Resumo: En | Texto: En | PDF: En

ABSTRACT Despite the importance of symbiotic nitrogen fixation (SNF) as a nitrogen source for leguminous plants, there are few reports of common bean breeding programs aiming at efficiency in SNF. This study aimed to analyze the interaction between elite lines of common bean with carioca grains and the nitrogen source (mineral fertilizer or SNF), and to select lines with wide adaptability, stability, high agronomic performance, and superiority in nodulation. Nineteen lines with carioca grains were evaluated in 12 environments in Brazil. In each environment, one experiment with mineral nitrogen fertilization and another with Rhizobium inoculation were set up, and agronomic traits were evaluated. Nodulation traits were evaluated in two years at one out of five location. Analyses of variance and of stability were performed, and Spearman’s correlations and the coincidence of selection of the best lines in both N sources were estimated. There is an effect of the N source and of genetic variability for all the traits. The lines were higher yielding under fertilization with mineral fertilizer, but they were more resistant to lodging when they were inoculated. The line by N source interaction was significant for 100-seed weight and resistance to lodging, but it did not affect selection of the best lines in the N sources. Eleven out of the 19 lines had no difference in grain yields between the two N sources. The line CNFC 15086 is recommended for growing in both N sources since it presented the highest yield and high adaptability and stability under both sources. The genotypes BRS Sublime, CNFC 15010, and CNFC 15003 had a high relative nodulation index and can be used in crosses with higher yielding lines. SNF (SNF plants SNF, , SNF) performance 1 Brazil environment up location performed Spearmans Spearman s estimated inoculated 100seed seed 100 1508 Sublime 15010 1500 10 150 1501 15

https://doi.org/10.1590/1678-4499.20230285

11.

Forage and macronutrient accumulation in grass-legume intercropping in a warm climate grasslegume grass legume
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Mesquita, Antonia Marta Sousa de

; Pompeu, Roberto Cláudio Fernandes Franco

; Cândido, Magno José Duarte

; Lopes, Marcos Neves

; Rogério, Marcos Cláudio Pinheiro

; Feitosa, Tibério Sousa

; Andrade, Hosana Aguiar Freitas de

; Almeida, Hilário de Júnior

; Souza, Henrique Antunes de

Revista Brasileira de Ciência do Solo

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2024, Volume 48 elocation e0230141

Resumo: En | Texto: En | PDF: En

ABSTRACT Diversifying pastures with forage legumes may reduce nitrogen fertilization due to biological N fixation. This study aimed to quantify forage accumulation rate and macronutrients extraction and to identify the best intercropping combination between butterfly pea (Clitoria ternatea) – a legume, and three warm-season forage grasses of different growth habits (signalgrass – Urochloa decumbunes, Guinea grass - Mega thyrsus maximus, and bermudagrass Cynodon dactylon). Treatments consisted of mixes of perennial herbaceous legume, butterfly pea (twining stem), with grasses, signalgrass (decumbent stem) and Guinea grass (erect stem), and bermudagrass (stoloniferous/rhizomatous). The experiment was arranged in a randomized complete block design, with three treatments and three replications. There was interaction between the intercropping combinations and cutting cycles for forage accumulation rate (FAR) and N, P, K, Ca, Mg, and S uptake. Phosphorus and K uptake was reduced from the second cycle onwards, except for the signalgrass-butterfly pea intercropping, whose reduction was only from the third cycle. Conversely, the signalgrass-butterfly pea and bermudagrass-butterfly pea intercropping did not differ from each other in relation to total N concentration in soil, but the signalgrass-butterfly pea intercropping showed total N concentration in soil higher than that of Guinea grass-butterfly pea intercropping. A higher predominance of the N-NH4+ form was observed in the soil. Grass-legume intercropping increased the demand for nutrients, which makes it indispensable to verify the export of macronutrients to know when to supply these nutrients removed from the soil solution. fixation Clitoria ternatea legume warmseason warm season decumbunes maximus dactylon. dactylon . dactylon) twining stem, stem , decumbent erect stoloniferous/rhizomatous. stoloniferousrhizomatous stoloniferous/rhizomatous stoloniferous rhizomatous (stoloniferous/rhizomatous) design replications FAR (FAR P Ca Mg onwards signalgrassbutterfly Conversely bermudagrassbutterfly grassbutterfly NNH4+ NNH4 NNH NH4+ NH4 NH N-NH4 Grasslegume Grass solution (stoloniferous/rhizomatous N-NH

https://doi.org/10.36783/18069657rbcs20230141

12.

Mental health of Brazilian students during the COVID-19 pandemic: the role of gratitude, optimism, and hope in reducing anxiety COVID19 COVID 19 COVID-1 pandemic gratitude optimism COVID1 1 COVID-
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Almansa, Joice Franciele Friedrich

; Trivilin, Tatiane

; Hutz, Claudio Simon

; de Almeida, Rosa Maria Martins

; Vazquez, Ana Claudia Souza

; de Freitas, Clarissa Pinto Pizarro

Trends in Psychiatry and Psychotherapy

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2024, Volume 46 elocation e20220496

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Abstract Objective To investigate the role of optimism, hope, and gratitude as psychosocial factors for healthy development, especially with regard to anxiety in college students in the context of coronavirus disease 2019 (COVID-19). Methods This is a quantitative, descriptive cross-sectional study. A sociodemographic questionnaire, the Brazilian Gratitude Scale (Escala Brasileira de Gratidão [B-GRAT]), and the Brazilian versions of an anxiety subscale, the Revised Life Orientation Test (LOT-R), Hope Index Scale, and BIG-FIVE were administered. Data were analyzed using the Mann-Whitney U test, the Kruskal-Wallis test, Spearman correlations, and hierarchical linear regression. Results A total of 297 students were assessed. The relationship between gratitude and anxiety became positive in the hierarchical linear analysis, contradicting the initial negative association between these variables according to the Spearman coefficients. This contradiction may be a result of the suppression effect. When gratitude was added to the model, these three variables together accounted for 38% of the variance in anxiety. This indicates that optimism, hope, and gratitude together are significant predictors, although optimism alone accounts for the greater part of the variance in decreased anxiety. Conclusion The data confirm that family and religiosity are protective factors against mental illness, specifically non-adaptive anxiety. Furthermore, developing optimism as a protective factor makes it possible to experience less anxiety while hope has the potential to provide the individual with multiple pathways to healthy development. This study highlights that gratitude plays a dual role in these relationships as it has the potential to be associated with anxious feelings with likely negative outcomes while at the same time it can drive positive psychosocial factors of optimism and hope, decreasing anxiety. development 201 COVID19. COVID19 COVID 19 . (COVID-19) quantitative crosssectional cross sectional questionnaire Escala BGRAT, BGRAT B GRAT , [B-GRAT]) subscale LOTR, LOTR LOT R (LOT-R) BIGFIVE BIG FIVE administered MannWhitney Mann Whitney test KruskalWallis Kruskal Wallis correlations regression 29 assessed analysis coefficients effect model 38 predictors illness nonadaptive non adaptive Furthermore 20 COVID1 1 (COVID-19 [B-GRAT] (LOT-R 2 3 (COVID-1 [B-GRAT (COVID- (COVID

https://doi.org/10.47626/2237-6089-2022-0496

13.

The role of chaperone-mediated autophagy in drug resistance chaperonemediated chaperone mediated
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Teixeira, Ana Beatriz da Silva

; Ramalho, Maria Carolina Clares

; Souza, Izadora de

; Andrade, Izabela Amélia Marques de

; Osawa, Isabeli Yumi Araújo

; Guedes, Camila Banca

; Oliveira, Beatriz Silva de

; Souza Filho, Cláudio Henrique Dahne de

; Silva, Tainá Lins da

; Moreno, Natália Cestari

; Latancia, Marcela Teatin

; Rocha, Clarissa Ribeiro Reily

Genetics and Molecular Biology

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2024, Volume 47 Supl. 1 elocation e20230317

Resumo: En | Texto: En | PDF: En

Abstract In the search for alternatives to overcome the challenge imposed by drug resistance development in cancer treatment, the modulation of autophagy has emerged as a promising alternative that has achieved good results in clinical trials. Nevertheless, most of these studies have overlooked a novel and selective type of autophagy: chaperone-mediated autophagy (CMA). Following its discovery, research into CMA’s contribution to tumor progression has accelerated rapidly. Therefore, we now understand that stress conditions are the primary signal responsible for modulating CMA in cancer cells. In turn, the degradation of proteins by CMA can offer important advantages for tumorigenesis, since tumor suppressor proteins are CMA targets. Such mutual interaction between the tumor microenvironment and CMA also plays a crucial part in establishing therapy resistance, making this discussion the focus of the present review. Thus, we highlight how suppression of LAMP2A can enhance the sensitivity of cancer cells to several drugs, just as downregulation of CMA activity can lead to resistance in certain cases. Given this panorama, it is important to identify selective modulators of CMA to enhance the therapeutic response. treatment trials Nevertheless chaperonemediated chaperone mediated CMA. . (CMA) discovery CMAs s rapidly Therefore turn tumorigenesis targets review Thus LAMPA LAMP A drugs cases panorama response (CMA

https://doi.org/10.1590/1678-4685-gmb-2023-0317

14.

ELEIÇÕES E DEMOCRACIA NO BRASIL: um desafio analítico permanente BRASIL
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Souza, Cláudio André de

; Santana, Luciana

Caderno CRH

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2024, Volume 37 elocation e024001

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.9771/ccrh.v37i0.58646

15.

Comparison between use of a pleural drainage system with flutter valve and a conventional water-seal drainage system after lung resection: a randomized prospective study waterseal water seal resection
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Souza, Rodrigo Caetano de

; Morais, Lilianne Louise Silva de

; Ghefter, Mario Claudio

; Franceschini, Juliana Pereira

; Pinto, Fernando Campos Gomes

Sao Paulo Medical Journal

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2024, Volume 142 Nº 5 elocation e2023224

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: There is still a debate regarding the most appropriate pleural collector model to ensure a short hospital stay and minimum complications. OBJECTIVES: To study aimed to compare the time of air leak, time to drain removal, and length of hospital stay between a standard water-seal drainage system and a pleural collector system with a unidirectional flutter valve and rigid chamber. DESIGN AND SETTING: A randomized prospective clinical trial was conducted at a high-complexity hospital in São Paulo, Brazil. METHODS: Sixty-three patients who underwent open or video-assisted thoracoscopic lung wedge resection or lobectomy were randomized into two groups, according to the drainage system used: the control group (WS), which used a conventional water-seal pleural collector, and the study group (V), which used a flutter valve device (Sinapi® Model XL1000®). Variables related to the drainage system, time of air leak, time to drain removal, and time spent in hospital were compared between the groups. RESULTS: Most patients (63%) had lung cancer. No differences were observed between the groups in the time of air leak or time spent hospitalized. The time to drain removal was slightly shorter in the V group; however, the difference was not statistically significant. Seven patients presented with surgery-related complications: five and two in the WS and V groups, respectively. CONCLUSIONS: Air leak, time to drain removal, and time spent in the hospital were similar between the groups. The system used in the V group resulted in no adverse events and was safe. REGISTRATION: RBR-85qq6jc (https://ensaiosclinicos.gov.br/rg/RBR-85qq6jc). BACKGROUND complications OBJECTIVES waterseal water seal chamber SETTING highcomplexity high complexity Paulo Brazil METHODS Sixtythree Sixty three videoassisted video assisted WS, , (WS) V, (V) Sinapi® Sinapi (Sinapi XL1000®. XL1000 XL XL1000® . XL1000®) RESULTS 63% 63 (63% cancer hospitalized however significant surgeryrelated surgery respectively CONCLUSIONS safe REGISTRATION RBR85qq6jc RBRqqjc RBR 85qq6jc qq jc https//ensaiosclinicos.gov.br/rg/RBR85qq6jc. httpsensaiosclinicosgovbrrgRBR85qq6jc httpsensaiosclinicosgovbrrgRBRqqjc https //ensaiosclinicos.gov.br/rg/RBR ensaiosclinicos gov br rg (https://ensaiosclinicos.gov.br/rg/RBR-85qq6jc) (WS (V XL100 6 (63 qqjc https//ensaiosclinicos.gov.br/rg/RBR85qq6jc httpsensaiosclinicosgovbrrgRBR ensaiosclinicosgovbrrgRBR (https://ensaiosclinicos.gov.br/rg/RBR-85qq6jc XL10 (6 XL1 (

https://doi.org/10.1590/1516-3180.2023.0224.r1.08022024

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