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[SciELO Preprints] - PREVALENCE OF BURNOUT SYNDROME IN HEALTH PROFESSIONALS DURING THE COVID-19 PANDEMIC
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Buffon, Viviane Aline Roeder, Barbara Laís Barros, Liana Leal de Sobral , Ana Cristina Lira Simm, Eduardo Bolicenha Bark, Guilherme Dorabiallo Bark, Samir Ale

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Data de publicação: 2023-05-16

Resumo: En Pt

Introduction: Burnout syndrome in the professional context is a condition caused by long-term stress in the workplace. In the face of the COVID-19 pandemic it has been observed that healthcare workers have experienced psychological health issues. Objective: This study aims to analyze different professional categories and sectors, identifying the main risk factors and coping mechanisms adopted by healthcare professionals associated with Burnout syndrome. Method: A literature search was conducted, and an electronic form was administered to healthcare professionals who provided direct medical care to COVID-19 diagnosed and hospitalized patients in the city of Curitiba, Brazil, from March 2020 to November 2021. The questionnaire included personal and professional information, as well as specific conditions experienced during the pandemic, coping strategies, and the application of the Maslach Burnout Inventory - Human Services Survey (MBI-HSS) to assess the prevalence of Burnout syndrome. Results: The sample consisted of 89 healthcare professionals, and a prevalence of 48.31% for Burnout syndrome was identified. No statistically significant results were found when analyzing different professional categories and sectors. However, changing sectors during the pandemic was statistically significant (p=0.0245), as well as seeking emotional/psychiatric/psychological support (p=0.0004), and the importance of using mediation during the pandemic (p=0.0027). Conclusions: Changing sectors during the pandemic was identified as the only risk factor in this study. The main coping mechanisms adopted by healthcare professionals during the COVID-19 pandemic to address Burnout syndrome included seeking emotional, psychological, and psychiatric support, as well as an increased use of psychotropic medication.

Introdução: A síndrome de Burnout no ambiente profissional é uma condição causada por estresse de longo prazo no local de trabalho e que diante da pandemia causada pela COVID-19, foram evidenciados agravos à saúde psíquica do trabalhador da saúde. Objetivo: Analisar as diferentes categorias e setores de atuação profissional, elencando os principais fatores de risco e as principais formas de enfrentamento adotadas pelos profissionais de saúde associados à síndrome de Burnout. Método: Foi realizada busca bibliográfica e aplicação de formulário eletrônico, aos profissionais de saúde que prestaram assistência médica direta a pacientes internados e hospitalizados com COVID-19 no município de CuritibaPR entre o período de março de 2020 a novembro de 2021; contendo comandos com informações pessoais,profissionais e relacionados com as condições específicas vivenciadas durante a pandemia/ medidas de enfrentamento e aplicação do teste Maslach Burnout Inventory – Human Services Survey (MBI-HSS) para análise da prevalência do Síndrome de Burnout. Resultados: A amostra foi composta por 89 profissionais de saúde. Evidenciou-se uma prevalência de 48,31% de Síndrome de Burnout. Não foram encontrados resultados estatisticamente ao analisar diferentes categorias profissionais e setores de atuação. A mudança de setor durante a pandemia foi estatisticamente significativa (p=0,0245), assim como a busca por apoio emocional/psiquiátrico/psicológico (p=0,0004) e seguro acerca do uso de mediação durante a pandemia (p= 0,0027). Conclusões:A mudança de setor durante uma pandemia foi considerada o único fator de risco encontrado no estudo. As principais formas de enfrentamento ao Síndrome de Burnout adotadas pelos profissionais de saúde durante a pandemia de COVID-19 foram a busca por apoio emocional, psicológico, psiquiátrico e aumento do uso de medicação psicotrópica

https://doi.org/10.1590/SciELOPreprints.6079

[SciELO Preprints] - EPIDEMIOLOGICAL PROFILE OF METASTATIC INTRACRANIAL TUMORS SUBMITTED TO NEUROSURGERY
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Buffon, Viviane Aline Conti, Bruna Passos Beltrame, Carolina Madsen Sobral, Ana Cristina Lira Simm, Eduardo Bolicenha Bark, Samir Ale

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Data de publicação: 2022-05-26

Resumo: En Pt

Introduction: Brain metastases are usually due to lung carcinoma, breast cancer and melanoma. The search to hospitals for neurological symptoms without prior knowledge of primary cancer is frequent. Objective: Analyze the epidemiological profile of patients with brain metastases. Method: This is a crosssectional study, with data collection from patients with brain metastases from the neurosurgery service, between 2010 and 2020. Results: The sample consisted of 114 patients and the main primary sites were lung (39 %), non-determined site (25%) and melanoma (15%). Most (61%) were unaware of the primary cancer. The most affected site was the frontal lobe (32%), on the right side (41%), and most lesions were single (68%). Conclusion: The epidemiological analysis corroborated most of the findings in the literature, with the primary pulmonary site and the discovery of metastasis before the primary cancer being the majority of cases.

Introdução: As metástases cerebrais são, geralmente, decorrentes de carcinoma pulmonar, mama e melanoma. A procura ao hospital por sintomas neurológicos sem o conhecimento prévio do câncer primário é frequente. Objetivos: Analisar o perfil epidemiológico dos pacientes com metástase cerebral. Método: Trata-se de um estudo transversal, com coleta de dados dos pacientes com metástases cerebrais entre 2010 a 2020. Resultados: A amostra foi de 114 pacientes e os principais sítios primários foram pulmão (39%), sítio não determinado (25%) e melanoma (15%). A maior parte (61%) desconhecia o câncer primário. O local mais acometido foi lobo frontal (32%), do lado direito (41%), e a maioria das lesões eram únicas (68%). Conclusão: A análise epidemiológica corroborou com grande parte dos achados na literatura, sendo o sítio primário pulmonar e a descoberta da metástase antes do câncer primário a maioria dos casos.

https://doi.org/10.1590/SciELOPreprints.4179

ALDH1 expression and potential clinical implications in chronic inflammatory periapical lesions
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Farias, Zilda Betânia Barbosa Medeiros de

; Silva, Leorik Pereira da

; de Arruda, José Alcides Almeida

; Cavalcante, Jade de Souza

; Almeida, Híttalo Carlos Rodrigues de

; Oliveira, Maria Cristina Valença de

; Souza, Lélia Batista de

; Sobral, Ana Paula Veras

Brazilian Oral Research

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2022, Volume 36 elocation e019

Resumo: En | Texto: En | PDF: En

Abstract: Aldehyde dehydrogenase 1 (ALDH-1) is a marker of stem cells in a variety of diseases, but its role in individuals with chronic inflammatory periapical lesions remains unknown. The aim of this study was to investigate the presence of cells with a stem cell profile based on the immunoexpression of ALDH-1 in periapical granulomas (PGs) and radicular cysts (RCs). A total of 51 cases of periapical lesions (25 PGs and 26 RCs) were subjected to immunohistochemical study. The anti-ALDH-1 antibody was applied using the immunoperoxidase technique. An immunoexpression score (intensity vs. percentage of cells) was used, with the cases being classified as low expression (score: 0 to 4) and high expression (score: 6 to 9). The Chi-square test was used with a 5% level of significance. Immunoexpression of ALDH-1 was detected in all cases of PGs and RCs. In PG cases, the expression was diffuse in connective tissue cells, with most cases exhibiting high expression (n = 18; 69.2%), while in RC cases the expression revealed focal distribution in cells of the capsule and epithelial cells of the cystic lining, with most cases classified as low expression (n = 18; 72%). Significant differences in the expression scores of ALDH-1 were observed in PGs (p = 0.003). The variable expression of ALDH-1 suggests the presence of cells with stem cell profiles in PGs and RCs. These findings suggest that periapical tissues infiltrated by chronic inflammation can recruit important cells for the repair or evolution of periapical lesions.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0019

β-micrustoxin (Mlx-9), a PLA2 from Micrurus lemniscatus snake venom: biochemical characterization and anti-proliferative effect mediated by p53
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Santos, Natália Fernanda Teixeira dos

; Imberg, Andréia de Souza

; Mariano, Douglas Oscar Ceolin

; Moraes, Angelina Cirelli de

; Andrade-Silva, Jessica

; Fernandes, Cristina Maria

; Sobral, Ana Cláudia

; Giannotti, Karina Cristina

; Kuwabara, Wilson M. Tatagiba

; Pimenta, Daniel Carvalho

; Maria, Durvanei Augusto

; Sandoval, Maria Regina Lopes

; Afeche, Solange Castro

Journal of Venomous Animals and Toxins including Tropical Diseases

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2022, Volume 28 elocation e20210094

Resumo: En | Texto: En | PDF: En

Abstract Background Endogenous phospholipases A2 (PLA2) play a fundamental role in inflammation, neurodegenerative diseases, apoptosis and cellular senescence. Neurotoxins with PLA2 activity are found in snake venoms from the Elapidae and Viperidae families. The mechanism of action of these neurotoxins have been studied using hippocampal and cerebellar neuronal cultures showing [Ca2+]i increase, mitochondrial depolarization and cell death. Astrocytes are rarely used as a model, despite being modulators at the synapses and responsible for homeostasis and defense in the central nervous system. Preserving the cell division ability, they can be utilized to study the cell proliferation process. In the present work cultured astrocytes and glioblastoma cells were employed to characterize the action of β-micrustoxin (previously named Mlx-9), a PLA2 isolated from Micrurus lemniscatus snake venom. The β-micrustoxin structure was determined and the cell proliferation, cell cycle phases and the regulatory proteins p53, p21 and p27 were investigated. Methods β-micrustoxin was characterized biochemically by a proteomic approach. Astrocytes were obtained by dissociation of pineal glands from Wistar rats; glioblastoma tumor cells were purchased from ATCC and Sigma and cultured in DMEM medium. Cell viability was evaluated by MTT assay; cell proliferation and cell cycle phases were analyzed by flow cytometry; p53, p21 and p27 proteins were studied by western blotting and immunocytochemistry. Results Proteomic analysis revealed fragments on β-micrustoxin that aligned with a PLA2 from Micrurus lemniscatus lemniscatus previously identified as transcript ID DN112835_C3_g9_i1/m.9019. β-micrustoxin impaired the viability of astrocytes and glioblastoma tumor cells. There was a reduction in cell proliferation, an increase in G2/M phase and activation of p53, p21 and p27 proteins in astrocytes. Conclusion These findings indicate that β-micrustoxin from Micrurus lemniscatus venom could inhibit cell proliferation through p53, p21 and p27 activation thus imposing cell cycle arrest at the checkpoint G2/M.

https://doi.org/10.1590/1678-9199-jvatitd-2021-0094

Tumor in Anterior Leaflet of the Mitral Valve
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Almeida, Francielle Santos

; Canevazzi, Gabriele Justo

; Rocha, Priscila Barão

; Sobral, Ana Cristina Carlomagno Molinari

; Sobral, Marcelo Luiz Peixoto

Brazilian Journal of Cardiovascular Surgery

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Fev 2021, Volume 36 Nº 1 Páginas 116 - 119

Resumo: En | Texto: En | PDF: En

https://doi.org/10.21470/1678-9741-2020-0557 176 downloads

The impact of visceral fat and levels of vitamin D on coronary artery calcification
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Rodrigues, Isa Galvão

; Pinho, Claudia Porto Sabino

; Sobral Filho, Dário

; Leão, Ana Paula Dornelas

; Oliveira, Maria Cristina Monterio

; Barbosa, Gerssica Pina

; Siqueira, Aline Alves de

; Bandeira, Francisco

Revista da Associação Médica Brasileira

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Jan 2021, Volume 67 Nº 1 Páginas 88 - 93

Resumo: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: To evaluated calcification of the coronary arteries and its association with visceral fat and 25-hydroxyvitamin D (25(OH)D) serum levels. METHODS: A cross sectional study involving 140 individuals without any previous diagnosis of cardiovascular disease. A biochemical analysis of vitamin D serum levels was carried out, as well as computed tomography to measure coronary artery calcium score and visceral adipose tissue. RESULTS: The mean age of the individuals was 55.9 (±12.4). Coronary artery calcium was observed in 40.7% of the population. Vitamin D presented median serum levels of 30.4 ng/ml (IQ24.5–39.1), with 14,1 and 33.7% of the individuals presenting deficiency and insufficiency, respectively. In the univariate analysis, the calcium score was more prevalent in aged patients (p<0.01), in hypertensive individuals (p<0.01), in diabetics (p=0.02), and in those with a higher concentration of VAT (p=0.02). In the adjusted analysis, it was found that the highest concentration of VAT (OR: 4.0; 95%CI 1.4–11.7), hypertension (OR: 4.8; 95%CI 1.5–15.3), and age (OR: 10.4; 95%CI 3.9–27.6) were predictors of subclinical atherosclerosis, regardless of body mass index, diabetes, and 25OHD. CONCLUSIONS: Excess visceral fat was associated with subclinical atherosclerosis, regardless of other risk factors for cardiovascular disease. Serum levels of 25OHD were not associated with CAD in its early stages.

https://doi.org/10.1590/1806-9282.67.01.20200388 309 downloads

Impacto de um modelo de supervisão clínica nas capacidades da inteligência emocional em enfermeiros
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Augusto, Maria Cristina Bompastor

; Oliveira, Karine Sobral de

; Carvalho, António Luís Rodrigues Faria de

; Pinto, Cristina Maria Correia Barroso

; Teixeira, Ana Isabel Carvalho

; Teixeira, Leonor Olímpia Lopes Sousa Morais

Rev Rene

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2021, Volume 22 elocation e60279

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective to analyze the impact of the implementation of a model of clinical supervision over the emotional intelligence capacities of nurses. Methods mixed methods study. Quantitative data were collected before and after the implementation of the Model, using the scale of Emotional Intelligence Capacities of Nurses; analyses were carried out using descriptive statistics and paired samples were analyzed using the t-test. 47 nurses from one hospital participated. Qualitative data were obtained from the analysis of the discourses of the nurses in a public presentation, using thematic/categorizing content analysis. The findings were integrated at the end to generate the results. Results no statistically significant differences were found with the implementation of the Model. However, the nurses involved recognized the positive impact of the SafeCare Model in the development of emotional competences. Conclusion the study contributed for clinical supervision and for the development of emotional competences.

RESUMO Objetivo analisar o impacto da implementação de um modelo de supervisão clínica em enfermagem nas capacidades da inteligência emocional dos enfermeiros. Métodos estudo de métodos mistos. Colheu-se os dados quantitativos antes e após a implementação do Modelo, pela escala Capacidades da Inteligência Emocional em Enfermeiros; analisou-se por estatística descritiva e pelo teste-t para amostras emparelhadas. Participaram 47 enfermeiros de um hospital. Obteve-se os dados qualitativos pela análise dos discursos dos enfermeiros numa apresentação pública, através de técnicas de análise de conteúdo tipo temática/categorial. Os achados foram integrados no final para gerar os resultados. Resultados não se verificou diferenças estatisticamente significativas com a implementação do Modelo. Contudo, os enfermeiros envolvidos reconheceram o impacto positivo do Modelo SafeCare no desenvolvimento das competências emocionais. Conclusão o estudo apresentou contributos para a supervisão clínica e para o desenvolvimento das competências emocionais.

https://doi.org/10.15253/2175-6783.20212260279 216 downloads

IS THERE CORRELATION BETWEEN HUMAN PAPILLOMAVIRUS (HPV) AND ESOPHAGEAL EPIDERMOID CARCINOMA?
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WOELLNER, Luiz Filipe Alkamin

; MEDEIROS, Juliano Smaniotto de

; RIBAS, Carmen Australia Paredes Marcondes

; NASSIF, Paulo Afonso Nunes

; RIBAS-FILHO, Jurandir Marcondes

; SOBRAL, Ana Cristina Lira

; ARIEDE, Bruno Luiz

; COSTA, Debora Azeredo Pacheco Dias DA

; MALAFAIA, Osvaldo

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2021, Volume 34 Nº 1 elocation e1528

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Racional: Atualmente a infecção persistente pelo papilomavírus humano (HPV) tem sido relacionada em algumas regiões geográficas como fator de risco para o carcinoma epidermoide do esôfago. Ela resulta na imunoexpressão da proteína p16, que tem sido utilizada como marcadora da linhagem oncogênica por este agente etiológico. Objetivo: Correlacionar aspectos epidemiológicos do carcinoma epidermoide do esôfago com a prevalência de infecção pelo HPV. Métodos: Foram analisados 58 casos buscando-se perfil epidemiológico dos pacientes, com suas peças submetidas à análise histopatológica e imunoistoquímica pelo p16. Resultado: Dos 58 casos avaliados, 40 eram homens e 18 mulheres, com idade média de 63,2 anos. A imunoexpressão pelo p16 foi de 46,55%. Conclusão: A prevalência de infecção pelo HPV é alta no carcinoma epidermoide de esôfago apresentando-se em quase a metade dos casos (46,55%), sem diferenciação de idade quanto aos gêneros.

ABSTRACT Background: Currently, persistent human papillomavirus (HPV) infection has been related in some geographic regions as a risk factor for esophageal squamous cell carcinoma. It results in the immunoexpression of the p16 protein, which has been used as marker of the oncogenic lineage by this etiological agent. Aim: To correlate epidemiological aspects of esophageal squamous cell carcinoma with the prevalence of HPV infection. Methods: Fifty-eight cases were analyzed and submitted to histopathological and immunohistochemical analysis by p16. Results: Of the 58 cases evaluated, 40 were men and 18 women, with a mean age of 63.2 years. p16 immunoexpression was positive in 46.55%. Conclusion: The prevalence of HPV infection is high in esophageal squamous cell carcinoma presenting in almost half of the cases (46.55%), without gender differentiation.

https://doi.org/10.1590/0102-672020200002e1528 690 downloads

SOFTWARE-ASSISTED IMAGE ANALYSIS FOR IDENTIFICATION AND QUANTIFICATION OF HEPATIC SINUSOIDAL DILATATION AND CENTRILOBULAR FIBROSIS
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GEWEHR, Douglas Mesadri

; GIOVANINI, Allan Fernando

; MUNHOZ, Sofia Inez

; NAGASHIMA, Seigo

; BERTOLDI, Andressa de Souza

; SOBRAL, Ana Cristina Lira

; KUBRUSLY, Fernando Bermudez

; KUBRUSLY, Luiz Fernando

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2021, Volume 34 Nº 2 elocation e1608

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Racional: Tecnologias de imagem digital têm sido introduzidas ao diagnóstico patológico, permitindo avaliações quantitativas objetivas. A quantificação de tecido fibroso em biópsias de fígado é extremamente importante para a classificação, diagnóstico e graduação de doenças crônicas hepáticas. Objetivo: Criar um protocolo computadorizado semi-automático para quantificação de fibrose centrolobular e dilatação sinusoidal em amostras de fígado coradas por Tricrômico de Masson. Método: Uma vez instaurada a fibrose, amostras de fígado foram coletadas, processadas histologicamente, coradas por Tricrômico de Masson e WSI (Whole Slide Images) foram capturadas por scanner digital patológico apropriado. Uma seleção aleatória das regiões de interesse (ROI) foi realizada. Os dados foram submetidos a uma análise de imagem assistida por software (ImageJ®). Resultados: A análise de 250 ROIs permitiu obter-se empiricamente as melhores configurações capazes de identificar fibrose centrolobular (FC) e lúmen sinusoidal (LS). Após o estabelecimento das configurações de padrão de cor, uma Macro de autoria própria foi gravada para definir as medidas (área da fração e área total) e calcular as razões de FC e LS por processamento em grupo/lote (batch mode). Conclusão: Foi possível criar um método detalhado capaz de identificar e quantificar a área ocupada por tecido fibroso e lúmen sinusoidal em espécimes de fígado coradas por Tricrômico de Masson.

ABSTRACT Background: Heart dysfunction and liver disease often coexist because of systemic disorders. Any cause of right ventricular failure may precipitate hepatic congestion and fibrosis. Digital image technologies have been introduced to pathology diagnosis, allowing an objective quantitative assessment. The quantification of fibrous tissue in liver biopsy sections is extremely important in the classification, diagnosis and grading of chronic liver disease. Aim: To create a semi-automatic computerized protocol to quantify any amount of centrilobular fibrosis and sinusoidal dilatation in liver Masson’s Trichrome-stained specimen. Method: Once fibrosis had been established, liver samples were collected, histologically processed, stained with Masson’s trichrome, and whole-slide images were captured with an appropriated digital pathology slide scanner. After, a random selection of the regions of interest (ROI’s) was conducted. The data were subjected to software-assisted image analysis (ImageJ®). Results: The analysis of 250 ROI’s allowed to empirically obtain the best application settings to identify the centrilobular fibrosis (CF) and sinusoidal lumen (SL). After the establishment of the colour threshold application settings, an in-house Macro was recorded to set the measurements (fraction area and total area) and calculate the CF and SL ratios by an automatic batch processing. Conclusion: Was possible to create a more detailed method that identifies and quantifies the area occupied by fibrous tissue and sinusoidal lumen in Masson’s trichrome-stained livers specimens.

https://doi.org/10.1590/0102-672020210002e1608 268 downloads

10.

Forward masking and cognitive-language skills in children as a function of literacy stage
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Fonsêca, Nathália Hollanda da

; Queiroga, Bianca Arruda Manchester de

; Montenegro, Ana Cristina de Albuquerque

; Menezes, Pedro de Lemos

; Menezes, Denise Costa

; Griz, Silvana Maria Sobral

Revista CEFAC

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2021, Volume 23 Nº 3 elocation e9121

Resumo: En | Texto: En | PDF: En

ABSTRACT Purpose: to investigate the relation between forward masking and cognitive-language skills in children as a function of literacy stage. Methods: twenty-seven children registered in literacy stage at public schools, aged from 6 to 9 years old, with no learning difficulties or audiological problems reported, participated in this study. Frequency Following Responses were registered in two test conditions: 1) /da/ alone; 2) /da/ presented 4 milliseconds after a speech noise. Two language protocols were applied: a cognitive-linguistic skills protocol and a phonological awareness one. Results: forward masking was evident in Frequency Following Responses of all children regardless of literacy stage. Frequency Following Responses latencies in both testing conditions showed no difference among participants’ age. Cognitive-language skills scores were below those expected for all children, with significant improvement noticed as a function of age. No correlation between language performance and forward masking was found. Conclusion: there was no relation between forward masking and cognitive-language skills in children, as a function of literacy stage.

https://doi.org/10.1590/1982-0216/20212339121

11.

Purification and characterization of fibrinolytic protease from Streptomyces parvulus by polyethylene glycol-phosphate aqueous two-phase system
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ALENCAR, VIVIANE N.S.

; NASCIMENTO, MARIA CLARA DO

; FERREIRA, JULYANNE V. DOS SANTOS

; BATISTA, JUANIZE M. DA SILVA

; CUNHA, MARCIA N.C. DA

; NASCIMENTO, JÉSSICA M. DO

; SOBRAL, RENATA V. DA SILVA

; COUTO, MILENA T.T. DO

; NASCIMENTO, THIAGO P.

; COSTA, ROMERO M.P.B.

; PORTO, ANA LÚCIA F.

; LEITE, ANA CRISTINA L.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 elocation e20210335

Resumo: En | Texto: En | PDF: En

Abstract Fibrinolytic proteases are a promising alternative in the pharmaceutical industry, they are used in the treatment of cardiovascular diseases, especially thrombosis. Microorganisms are the most interesting source of fibrinolytic proteases. The aim of this study was the production of fibrinolytic protease from Streptomyces parvulus DPUA 1573, the recovery of the protease by aqueous two-phase system and partial biochemical characterization of the enzyme. The aqueous two-phase system was performed according to a 24-full factorial design using polyethylene glycol molar mass, polyethylene glycol concentration, citrate concentration and pH as independent variables. It was analyzed the effect of different ions, surfactants, inhibitors, pH and temperature on enzyme activity. The best conditions for purifying the enzyme were 17.5% polyethylene glycol 8,000, 15% Phosphate and pH 8.0, it was obtained a partition coefficient of 7.33, a yield of 57.49% and a purification factor of 2.10-fold. There was an increase in enzyme activity in the presence of Fe2+ and a decrease in the presence of $\beta$-Mercaptoethanol, phenylmethylsulfonyl fluoride and Iodoacetic acid. The optimum pH was 7.0 and the optimum temperature was 40 ºC. The purified protease exhibited a molecular mass of 41 kDa. The fibrinolytic protease from Streptomyces parvulus proved to be a viable option for the development of a possible drug with fibrinolytic action.

https://doi.org/10.1590/0001-3765202120210335 1 downloads

12.

Diretriz Brasileira de Cardio-oncologia – 2020
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Hajjar, Ludhmila Abrahão

; Costa, Isabela Bispo Santos da Silva da

; Lopes, Marcelo Antônio Cartaxo Queiroga

; Hoff, Paulo Marcelo Gehm

; Diz, Maria Del Pilar Estevez

; Fonseca, Silvia Moulin Ribeiro

; Bittar, Cristina Salvadori

; Rehder, Marília Harumi Higuchi dos Santos

; Rizk, Stephanie Itala

; Almeida, Dirceu Rodrigues

; Fernandes, Gustavo dos Santos

; Beck-da-Silva, Luís

; Campos, Carlos Augusto Homem de Magalhães

; Montera, Marcelo Westerlund

; Alves, Sílvia Marinho Martins

; Fukushima, Júlia Tizue

; Santos, Maria Verônica Câmara dos

; Negrão, Carlos Eduardo

; Silva, Thiago Liguori Feliciano da

; Ferreira, Silvia Moreira Ayub

; Malachias, Marcus Vinicius Bolivar

; Moreira, Maria da Consolação Vieira

; Valente Neto, Manuel Maria Ramos

; Fonseca, Veronica Cristina Quiroga

; Soeiro, Maria Carolina Feres de Almeida

; Alves, Juliana Barbosa Sobral

; Silva, Carolina Maria Pinto Domingues Carvalho

; Sbano, João

; Pavanello, Ricardo

; Pinto, Ibraim Masciarelli F.

; Simão, Antônio Felipe

; Dracoulakis, Marianna Deway Andrade

; Hoff, Ana Oliveira

; Assunção, Bruna Morhy Borges Leal

; Novis, Yana

; Testa, Laura

; Alencar Filho, Aristóteles Comte de

; Cruz, Cecília Beatriz Bittencourt Viana

; Pereira, Juliana

; Garcia, Diego Ribeiro

; Nomura, Cesar Higa

; Rochitte, Carlos Eduardo

; Macedo, Ariane Vieira Scarlatelli

; Marcatti, Patricia Tavares Felipe

; Mathias Junior, Wilson

; Wiermann, Evanius Garcia

; Val, Renata do

; Freitas, Helano

; Coutinho, Anelisa

; Mathias, Clarissa Maria de Cerqueira

; Vieira, Fernando Meton de Alencar Camara

; Sasse, André Deeke

; Rocha, Vanderson

; Ramires, José Antônio Franchini

; Kalil Filho, Roberto

Arquivos Brasileiros de Cardiologia

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Nov 2020, Volume 115 Nº 5 Páginas 1006 - 1043

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201006 4180 downloads

13.

Atualização das Diretrizes em Cardiogeriatria da Sociedade Brasileira de Cardiologia – 2019
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Feitosa Filho, Gilson Soares

; Peixoto, José Maria

; Pinheiro, José Elias Soares

; Afiune Neto, Abrahão

; Albuquerque, Afonso Luiz Tavares de

; Cattani, Álvaro César

; Nussbacher, Amit

; Camarano, Ana Amelia

; Sichinels, Angela Hermínia

; Sousa, Antonio Carlos Sobral

; Alencar Filho, Aristóteles Comte de

; Gravina, Claudia F.

; Sobral Filho, Dario Celestino

; Pitthan, Eduardo

; Costa, Elisa Franco de Assis

; Duarte, Elizabeth da Rosa

; Freitas, Elizabete Viana de

; Moriguchi, Emilio Hideyuki

; Mesquita, Evandro Tinoco

; Fernandes, Fábio

; Fuchs, Felipe Costa

; Feitosa, Gilson Soares

; Pierre, Humberto

; Pereira Filho, Ilnei

; Helber, Izo

; Borges, Jairo Lins

; Garcia, Jéssica Myrian de Amorim

; Souza, José Antonio Gordillo de

; Zanon, José Carlos da Costa

; Alves, Josmar de Castro

; Mohallem, Kalil Lays

; Chaves, Laura Mariana de Siqueira Mendonça

; Moura, Lídia Ana Zytynski

; Silva, Márcia Cristina Amélia da

; Toledo, Maria Alice de Vilhena

; Assunção, Maria Elisa Lucena Sales de Melo

; Wajngarten, Mauricio

; Gonçalves, Mauro José Oliveira

; Lopes, Neuza Helena Moreira

; Rodrigues, Nezilour Lobato

; Toscano, Paulo Roberto Pereira

; Rousseff, Pedro

; Maia, Ricardo Antonio Rosado

; Franken, Roberto Alexandre

; Miranda, Roberto Dischinger

; Gamarski, Roberto

; Rosa, Ronaldo Fernandes

; Santos, Silvio Carlos de Moraes

; Galera, Siulmara Cristina

; Grespan, Stela Maris da Silva

; Silva, Teresa Cristina Rogerio da

; Esteves, William Antonio de Magalhães

Arquivos Brasileiros de Cardiologia

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Mai 2019, Volume 112 Nº 5 Páginas 649 - 705

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.5935/abc.20190086 15622 downloads

14.

Resistance exercise recovery morphology and AQP1 expression in denervated soleus muscle of Wistar rats
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Lovison, Keli

; Vieira, Lizyana

; Kunz, Regina Inês

; Scarton, Suellen Ribeiro da Silva

; Antunes, Juliana Sobral

; Karvat, Jhenifer

; Peretti, Ana Luiza

; Bertolini, Gladson Ricardo Flor

; Brancalhão, Rose Meire Costa

; Beu, Célia Cristina Leme

; Ribeiro, Lucinéia de Fátima Chasko

Motricidade

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Mai 2018, Volume 14 Nº 1 Páginas 40 - 50

Resumo: En | Texto: En | PDF: En

It was our objective to analyse the effects of resistance exercise (climbing steps), which was started in the acute phase, on the histomorphometry and the expression of aquaporin 1 (AQP1) in the soleus muscle after sciatic nerve injury in Wistar rats. Twenty-four adult rats were randomly divided into the following four groups, containing six animals each: control (G1); exercise (G2); injury (G3); and exercise with injury (G4). Three days after the compression of the sciatic nerve, the animals in G2 and G4 were submitted to resistance exercise for 21 non-consecutives days. The exercise was conducted in two series of 10 consecutive ascents of the ladder, with an additional weight of 100g and with an interval of 60 seconds between sets for rest. After this period, the animals were sacrificed, and the soleus muscle was processed. The number of blood capillaries in G3 was 65.7% and 76.86% higher when compared with the G2 and G4, respectively. The morphological analysis revealed muscle damage in G3, hypertrophy in G2 and significant improvement in the muscle in G4. The AQP1 was immunolocalized in the endothelium of blood capillaries present in the muscle fibres, with different expressions in the groups. Resistance exercise initiated in the acute phase was an effective therapeutic modality in the recovery of morphological aspects in the soleus muscle after denervation.

392 downloads

15.

Characterization of victims of aggression and transportation accidents treated at the Forensic Medicine and Dentistry Institute - Campina Grande, Paraíba, Brazil - 2010
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d'Avila, Sergio

; Campos, Ana Cristina

; Cavalcante, Gigliana Maria Sobral

; Silva, Carlos Jose de Paula

; Nóbrega, Lorena Marques da

; Ferreira, Efigenia Ferreira e

Ciência & Saúde Coletiva

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Mar 2015, Volume 20 Nº 3 Páginas 887 - 894

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

O objetivo deste estudo tranversal censitário foi caracterizar a agressão e os acidentes de transporte terrestre em uma cidade do nordeste do Brasil. Foram analisados os dados de vítimas vivas que foram atendidas em um serviço forense (N = 2.379). Na análise descritiva, a maioria dos eventos foi a agressão (71,6%); que ocorreu nos dias úteis (65%), sendo 35,1% no período noturno. Os traumas ocorreram no corpo todo (63,6%) e envolveram o tecido mole (74,2%). A partir da análise de correspondência múltipla formaram-se duas dimensões: a primeira dimensão (confiabilidade interna = 0,654) foi formada pela causa do evento, o trauma e a faixa etária e, a segunda dimensão (confiabilidade interna = 0,514), pela faixa etária, a ocupação e o estado civil. Formaram-se três grupos com perfis distintos para os acidentes e agressão. Mulheres jovens que sofreram agressões com traumas faciais, em tecidos moles, no período da tarde e durante os finais de semana. Homens, adultos que sofreram acidentes automobilísticos, pela manhã e em dias úteis, e idosos, viú vos, aposentados e que sofreram atropelamento. Há um elevado número de vítimas de agressão interpessoal, seguido por acidentes de moto e os tipos de acidentes estão associados a grupos populacionais.

The objective of this cross-sectional census study was to characterize agression and land-based transport accidents in a city in the Northeast of Brazil. Data was analyzed from live victims who were treated at a forensic service (N = 2.379). In the descriptive analysis, the majority of events were represented by aggression (71.6%); which occurred on weekdays (65%), with 35.1% at night. Trauma occurred to the whole body (63.6%) and to soft tissue (74.2%). On the basis of multiple correspondence analysis, two dimensions were formed: the first dimension (internal reliability = 0.654) was formed by the cause of the event, the trauma and the age group and the second dimension (reliability = 0.514), by age group, occupation and civil status. Three groups with distinct profiles were formed for accidents and aggression: young women who suffered aggression, with trauma to the face and soft tissues during the evening and at weekends; adult men who suffered car accidents, in the morning and on work days; and retired elderly widowers, who were run over.

https://doi.org/10.1590/1413-81232015203.12922014 1625 downloads

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