ABSTRACT The sharpshooter genus Balacha Melichar, 1926 includes nine species and is distributed in southeastern and southern Brazil, Uruguay, Paraguay, and Argentina. All species of Balacha use only members of the genus Eryngium (Apiaceae) as host plants, except for a recently described species that is associated with Actinocephalus polyanthus (Eriocaulaceae). Here we describe and illustrate an additional species, B. caledonia sp. nov., from an alpine field in Nova Friburgo, state of Rio de Janeiro, southeastern Brazil, which is also associated with Eryngium. Among the known species of the genus, the new taxon is morphologically most similar to B. caparao Takiya & Mejdalani, 2004, but can be easily distinguished by the shaft of the aedeagus, which has a dorsal lobe on the basal half and no ventroapical lobe, and the female sternite VII with the borders of the posterior emargination sinuous. Our studies indicate that the type locality of the new species and its surrounding Atlantic Forest area in Nova Friburgo harbor an interesting and diverse but still poorly known sharpshooter fauna, including the recently discovered Paratubana auromarginata Côrte et al., 2021 (also from Eryngium) and Cavichiana caelivittata Mejdalani et al., 2023 (from bromeliads). Melichar 192 Brazil Uruguay Paraguay Argentina Apiaceae (Apiaceae plants Eriocaulaceae. Eriocaulaceae . (Eriocaulaceae) B sp nov nov. Janeiro 2004 aedeagus sinuous fauna al al. 202 bromeliads. bromeliads bromeliads) 19 (Eriocaulaceae 200 20 1 2

Abstract The aim of this study was to evaluate the impact of oral conditions and health-related quality of life (HRQoL) on oral health-related quality of life (OHRQoL) in children and adolescents with blood coagulation disorders and hemoglobinopathies (BCDH). The study was cross-sectional and included 61 individuals aged 2 to 18 years with BCDH. Exams for dental caries (dmft/DMFT index), oral hygiene (simplified oral hygiene index – OHI-S), and gingival health (modified gingival index – MGI) were performed. The pediatric quality of life inventory™ (PedsQL™) generic core scale and oral health scale were used to measure HRQoL and OHRQoL. Spearman’s correlation coefficient (ρ) and the Mann-Whitney test (α = 0.05) were conducted to assess the relationship between covariates and the PedsQL™ oral health scale. The mean PedsQL™ oral health scale score was 76.66 (SD = 21.36). Worse OHRQoL was correlated with poor oral hygiene (ρ = -0.383; p: 0.004), poor gingival health (ρ = -0.327; p = 0.014), and better HRQoL (ρ = 0.488; p < 0.001). Greater untreated dental caries experience was associated with worse OHRQoL (p = 0.009). Worse oral health status in children and adolescents with BCDH negatively impacts OHRQoL, and OHRQoL and quality of life analyzed from a generic perspective are positively correlated constructs in this population. healthrelated related (HRQoL (OHRQoL . (BCDH) crosssectional cross sectional 6 1 dmft/DMFT dmftDMFT dmft DMFT index, , index) simplified OHIS, OHIS OHI S OHI-S) modified MGI performed inventory PedsQL (PedsQL™ Spearmans Spearman s ρ MannWhitney Mann Whitney α 0.05 005 0 05 7666 76 66 76.6 SD 21.36. 2136 21.36 21 36 21.36) 0.383 0383 383 -0.383 0.004, 0004 0.004 004 0.004) 0.327 0327 327 -0.327 0.014, 0014 0.014 014 0.014) 0.488 0488 488 0.001. 0001 0.001 001 0.001) 0.009. 0009 0.009 009 0.009) population (BCDH OHI-S (PedsQL 0.0 00 766 7 76. 213 21.3 3 0.38 038 38 -0.38 000 0.00 0.32 032 32 -0.32 0.01 01 0.48 048 48 0. 21. 0.3 03 -0.3 0.4 04 4 -0. -0 -

ABSTRACT Objective: Abdominal ultrasonography is widely used to evaluate suspected cases of appendicitis. Objective descriptions of the direct and indirect signs of appendicitis result in varied assessments of its likelihood. This study introduces the Appendix Imaging Reporting and Data System (APENDIC-RADS) to standardize the reporting of appendix ultrasound findings. Methods: This single-center retrospective study included consecutive patients of all ages who underwent abdominal ultrasonography for the investigation of acute appendicitis. The primary outcome was histopathological confirmation of acute appendicitis post-surgery. The imaging findings were classified into five categories: APENDIC-RADS 0, where the appendix cannot be visualized; APENDIC-RADS 1, indicating a normal appendix; APENDIC-RADS 2, describing an appendix that is likely normal but only partially visualized; APENDIC-RADS 3, appendicitis cannot be ruled out due to uncertain features and APENDIC-RADS 4, acute appendicitis. Results: A total of 747 patients were assessed for suspected acute appendicitis using ultrasonography. Of the diagnosed patients, 52% were male, primarily exhibiting symptoms such as nausea and/or vomiting (60%), right iliac fossa pain (54%), and sudden decompression in the right iliac fossa (24%). Stratification into APENDIC-RADS categories revealed a significant variation in the incidence of acute appendicitis, with incidence rates of 4.5% for category 0 and 0.7%, 2.2%, 11.5%, and 93.5% for categories 1 to 4, respectively (p<0.001). The APENDIC-RADS showed excellent discriminative ability, evidenced by an area under the receiver operating characteristic curve of 0.950 (95%CI=0.899-1). Conclusion: APENDIC-RADS categorization demonstrated excellent performance in standardizing the ultrasound-determined probability of acute appendicitis. Its implementation could improve physician communication and standardization of patient management. likelihood APENDICRADS APENDIC RADS (APENDIC-RADS Methods singlecenter single center postsurgery. postsurgery post surgery. surgery post-surgery visualized 2 3 4 Results 74 52 male andor or 60%, 60 60% , (60%) 54%, 54 54% (54%) 24%. 24 24% . (24%) 45 5 4.5 07 7 0.7% 22 2.2% 115 11 11.5% 935 93 93.5 p<0.001. p0001 p p<0.001 001 (p<0.001) ability 0950 950 0.95 95%CI=0.8991. 95CI08991 CI 95%CI=0.899 95 899 (95%CI=0.899-1) Conclusion ultrasounddetermined determined management 6 (60% (54% (24% 4. 0.7 2.2 11.5 9 93. p000 p<0.00 00 (p<0.001 095 0.9 8991 95%CI=0.8991 95CI0899 95%CI=0.89 89 (95%CI=0.899-1 (60 (54 (24 0. 2. 11. p00 p<0.0 (p<0.00 09 95CI089 95%CI=0.8 8 (95%CI=0.899- (6 (5 (2 p0 p<0. (p<0.0 95CI08 95%CI=0. (95%CI=0.899 ( p<0 (p<0. 95CI0 95%CI=0 (95%CI=0.89 p< (p<0 95CI 95%CI= (95%CI=0.8 (p< 95%CI (95%CI=0. (p (95%CI=0 (95%CI= (95%CI

RESUMO OBJETIVO Analisar as tendências da mortalidade por câncer de colo de útero nos estados da região Sudeste e compará-las com o Brasil e demais regiões entre 1980 e 2020. MÉTODOS Estudo de série temporal com base nos dados do Sistema de Informações de Mortalidade. Os dados de óbito foram corrigidos por redistribuição proporcional das mortes por causas mal definidas e por câncer de útero de porção não especificada. Foram calculadas taxas padronizadas por idade e específicas por faixas etárias alvo de rastreamento (25–39 anos; 40–64 anos) e não alvo (65 anos ou mais). Variações percentuais anuais foram estimadas por modelo de regressão linear com pontos de quebra. A cobertura do exame Papanicolaou no Sistema Único de Saúde (SUS) foi avaliada entre 2009 e 2020 segundo faixa etária e localidade. RESULTADOS Foram verificados aumentos das taxas de mortalidade corrigidas tanto em 1980 como em 2020 em todas as regiões, com incrementos mais evidentes no início da série. Houve queda da mortalidade em todo o país entre 1980–2020, entretanto, o estado de São Paulo apresentou discreta tendência de aumento em 2014–2020 (APC=1,237; IC95% 0,046–2,443). Destaca-se o incremento da tendência no grupo de 25–39 anos em todas as localidades de estudo, mostrando-se mais acentuado na região Sudeste em 2013–2020 (APC=5,072; IC95% 3,971–6,185). As taxas de cobertura de rastreamento foram mais elevadas em São Paulo e mais baixas no Rio de Janeiro, com queda consistente a partir de 2012 em todas as idades. CONCLUSÕES São Paulo é o primeiro estado brasileiro a apresentar inversão de tendência da mortalidade por câncer de colo do útero. As mudanças nos padrões de mortalidade identificadas neste estudo apontam para a necessidade de reorganização do atual programa de rastreamento, que deve ser aperfeiçoado para garantir alta cobertura, qualidade e seguimento adequado de todas as mulheres com exames alterados. comparálas compará las 198 Mortalidade especificada 2539 25 39 (25–3 4064 40 64 40–6 65 (6 mais. . mais) quebra SUS (SUS 200 202 localidade 19802020 1980–2020 entretanto 20142020 2014 2014–202 APC=1,237 APC1237 APC 1 237 (APC=1,237 IC95 IC 0,046–2,443. 00462443 0,046–2,443 0 046 2 443 0,046–2,443) Destacase Destaca se 25–3 mostrandose mostrando 20132020 2013 2013–202 APC=5,072 APC5072 5 072 (APC=5,072 3,971–6,185. 39716185 3,971–6,185 3 971 6 185 3,971–6,185) Janeiro 201 idades alterados 19 253 (25– 406 4 40– ( 20 1980202 1980–202 2014202 2014–20 APC=1,23 APC123 23 (APC=1,23 IC9 0046244 0,046–2,44 04 44 25– 2013202 2013–20 APC=5,07 APC507 07 (APC=5,07 3971618 3,971–6,18 97 18 (25 198020 1980–20 201420 2014–2 APC=1,2 APC12 (APC=1,2 004624 0,046–2,4 201320 2013–2 APC=5,0 APC50 (APC=5,0 397161 3,971–6,1 9 (2 19802 1980–2 20142 2014– APC=1, APC1 (APC=1, 00462 0,046–2, 20132 2013– APC=5, APC5 (APC=5, 39716 3,971–6, 1980– APC=1 (APC=1 0046 0,046–2 APC=5 (APC=5 3971 3,971–6 APC= (APC= 004 0,046– 397 3,971– (APC 00 0,046 3,971 0,04 3,97 0,0 3,9 0, 3,

ABSTRACT OBJECTIVE To analyze the trends of cervical cancer mortality in Brazilian Southeastern states, and to compare them to Brazil and other regions between 1980 and 2020. METHODS Time series study based on data from the Sistema de Informações de Mortalidade (Brazilian Mortality Information System). Death data were corrected by proportional redistribution of deaths from ill-defined causes and cervical cancer of unspecified portion. Age-standardized and age-specific rates were calculated by screening target (25–39 years; 40–64 years) and non-target (65 years or older) age groups. Annual percentage changes (APC) were estimated by linear regression model with breakpoints. The coverage of Pap Smear exam in the Unified Health System (SUS) was evaluated between 2009 and 2020 according to age group and locality. RESULTS There were increases in corrected mortality rates both in 1980 and in 2020 in all regions, with most evident increments at the beginning of the series. There was a decrease in mortality nationwide between 1980–2020; however, the state of São Paulo showed a discrete upward trend in 2014–2020 (APC=1.237; 95%CI 0.046–2.443). Noteworthy is the trend increment in the 25–39 year-old group in all study localities, being sharper in the Southeast region in 2013–2020 (APC=5.072; 95%CI 3.971–6.185). Screening coverage rates were highest in São Paulo and lowest in Rio de Janeiro, with a consistent decline from 2012 onwards at all ages. CONCLUSIONS São Paulo is the first Brazilian state to show a reversal trend in mortality from cervical cancer. The changes in mortality patterns identified in this study point to the need for reorganization of the current screening program, which should be improved to ensure high coverage, quality, and adequate follow-up of all women with altered test results. states 198 System. . System) illdefined ill defined portion Agestandardized Age standardized agespecific specific 2539 25 39 (25–3 4064 40 64 40–6 nontarget non 65 (6 older groups APC (APC breakpoints SUS (SUS 200 202 locality 1980–2020 19802020 however 20142020 2014 2014–202 APC=1.237 APC1237 1 237 (APC=1.237 95CI CI 95 0.046–2.443. 00462443 0.046–2.443 0 046 2 443 0.046–2.443) 25–3 yearold year old localities 20132020 2013 2013–202 APC=5.072 APC5072 5 072 (APC=5.072 3.971–6.185. 39716185 3.971–6.185 3 971 6 185 3.971–6.185) Janeiro 201 ages program quality followup follow up results 19 253 (25– 406 4 40– ( 20 1980–202 1980202 2014202 2014–20 APC=1.23 APC123 23 (APC=1.23 9 0046244 0.046–2.44 04 44 25– 2013202 2013–20 APC=5.07 APC507 07 (APC=5.07 3971618 3.971–6.18 97 18 (25 1980–20 198020 201420 2014–2 APC=1.2 APC12 (APC=1.2 004624 0.046–2.4 201320 2013–2 APC=5.0 APC50 (APC=5.0 397161 3.971–6.1 (2 1980–2 19802 20142 2014– APC=1. APC1 (APC=1. 00462 0.046–2. 20132 2013– APC=5. APC5 (APC=5. 39716 3.971–6. 1980– APC=1 (APC=1 0046 0.046–2 APC=5 (APC=5 3971 3.971–6 APC= (APC= 004 0.046– 397 3.971– 00 0.046 3.971 0.04 3.97 0.0 3.9 0. 3.

ABSTRACT OBJECTIVE To analyze the trends of cervical cancer mortality in Brazilian Southeastern states, and to compare them to Brazil and other regions between 1980 and 2020. METHODS Time series study based on data from the Sistema de Informações de Mortalidade (Brazilian Mortality Information System). Death data were corrected by proportional redistribution of deaths from ill-defined causes and cervical cancer of unspecified portion. Age-standardized and age-specific rates were calculated by screening target (25–39 years; 40–64 years) and non-target (65 years or older) age groups. Annual percentage changes (APC) were estimated by linear regression model with breakpoints. The coverage of Pap Smear exam in the Unified Health System (SUS) was evaluated between 2009 and 2020 according to age group and locality. RESULTS There were increases in corrected mortality rates both in 1980 and in 2020 in all regions, with most evident increments at the beginning of the series. There was a decrease in mortality nationwide between 1980–2020; however, the state of São Paulo showed a discrete upward trend in 2014–2020 (APC=1.237; 95%CI 0.046–2.443). Noteworthy is the trend increment in the 25–39 year-old group in all study localities, being sharper in the Southeast region in 2013–2020 (APC=5.072; 95%CI 3.971–6.185). Screening coverage rates were highest in São Paulo and lowest in Rio de Janeiro, with a consistent decline from 2012 onwards at all ages. CONCLUSIONS São Paulo is the first Brazilian state to show a reversal trend in mortality from cervical cancer. The changes in mortality patterns identified in this study point to the need for reorganization of the current screening program, which should be improved to ensure high coverage, quality, and adequate follow-up of all women with altered test results.

RESUMO OBJETIVO Analisar as tendências da mortalidade por câncer de colo de útero nos estados da região Sudeste e compará-las com o Brasil e demais regiões entre 1980 e 2020. MÉTODOS Estudo de série temporal com base nos dados do Sistema de Informações de Mortalidade. Os dados de óbito foram corrigidos por redistribuição proporcional das mortes por causas mal definidas e por câncer de útero de porção não especificada. Foram calculadas taxas padronizadas por idade e específicas por faixas etárias alvo de rastreamento (25–39 anos; 40–64 anos) e não alvo (65 anos ou mais). Variações percentuais anuais foram estimadas por modelo de regressão linear com pontos de quebra. A cobertura do exame Papanicolaou no Sistema Único de Saúde (SUS) foi avaliada entre 2009 e 2020 segundo faixa etária e localidade. RESULTADOS Foram verificados aumentos das taxas de mortalidade corrigidas tanto em 1980 como em 2020 em todas as regiões, com incrementos mais evidentes no início da série. Houve queda da mortalidade em todo o país entre 1980–2020, entretanto, o estado de São Paulo apresentou discreta tendência de aumento em 2014–2020 (APC=1,237; IC95% 0,046–2,443). Destaca-se o incremento da tendência no grupo de 25–39 anos em todas as localidades de estudo, mostrando-se mais acentuado na região Sudeste em 2013–2020 (APC=5,072; IC95% 3,971–6,185). As taxas de cobertura de rastreamento foram mais elevadas em São Paulo e mais baixas no Rio de Janeiro, com queda consistente a partir de 2012 em todas as idades. CONCLUSÕES São Paulo é o primeiro estado brasileiro a apresentar inversão de tendência da mortalidade por câncer de colo do útero. As mudanças nos padrões de mortalidade identificadas neste estudo apontam para a necessidade de reorganização do atual programa de rastreamento, que deve ser aperfeiçoado para garantir alta cobertura, qualidade e seguimento adequado de todas as mulheres com exames alterados.

RESUMO A cultura do feijão fava (Phaseolus lunatus) pode ser considerada uma alternativa de renda e fonte de alimento aos agricultores do Nordeste brasileiro, no entanto depara-se com graves problemas sanitários. Dentre as principais doenças encontradas em campos de produção, destaca-se a antracnose causada por Colletotrichum truncatum. O objetivo do trabalho foi determinar a resistência de acessos de feijão fava a isolados de C. truncatum. Foram utilizadas folhas destacadas pertencentes a dez acessos de feijão-fava originados de campos de produção no Estado da Paraíba, inoculadas artificialmente por dez isolados de C. truncatum. Os isolados foram cultivados em meio de cultura feijão, dextrose e ágar, sob temperatura de 27 ± 2 ºC e fotoperíodo de 12 horas durante quatorze dias. As avaliações de resistência foram realizadas aos 5, 7, 9, 11 e 13 dias após a inoculação, adotando-se escala de notas e os resultados foram transformados em área abaixo da curva de progresso da doença. O delineamento experimental utilizado foi inteiramente casualizado, arranjados em esquema fatorial 10x10 com 12 repetições. Os primeiros sintomas da antracnose surgiram a partir do terceiro dias após a inoculação. A maior agressividade entre os isolados de C. truncatum aos acessos de feijão fava foi observada para o isolado CT35. Os acessos foram agrupados de altamente a moderadamente resistente ou suscetível. A agressividade entre os isolados de C. truncatum foi alterada em função da variabilidade de resistência dos acessos de feijão-fava. Os acessos com grau de resistência à antracnose podem servir de fontes de resistência em cruzamentos futuros.

ABSTRACT Lima bean (Phaseolus lunatus) can be considered as an alternative income and food supply to farmers of the Brazilian Northeast. This crop has faced serious sanitary problems. Among the most important diseases that attack this crop, the anthracnose caused by Colletotrichum truncatum requires greater attention. This study aimed to determine the resistance of lima bean accessions to the isolates of C. truncatum. Detached leaves were used from ten lima bean accessions, originated from production fields in Paraíba State - Brazil. They were artificially inoculated with ten isolates of C. truncatum. The isolates were grown on bean-dextroseagar medium under temperature 27 ± 2 °C and a photoperiod of 12 hours, for fourteen days. The evaluations of the accessions’ resistance to the isolates were performed at 5, 7, 9, 11 and 13 days after inoculation (DAI), adopting a scale of notes, and the results were transformed in the area under the disease progress curve. The research was carried out in completely randomized design, in a 10x10 factorial arrangement (accessions x isolates) with 12 replications. The first symptoms of anthracnose on the detached leaves appeared from the third day after inoculation. The accessions were grouped from highly to moderately resistant or susceptive. The aggressiveness among C. truncatum isolates varied depending on the genetic variability of the lima bean accessions used. Accessions with significant resistance levels to anthracnose can be used as resistance sources in future breeding programs.

RESUMO Os medicamentos reaproveitados são importantes em contextos de recursos limitados porque as intervenções estão mais rapidamente disponíveis, já foram testadas com segurança em outras populações e são, em geral, mais baratas. Os medicamentos reaproveitados são uma solução eficaz, especialmente para doenças emergentes, como a COVID-19. O estudo REVOLUTIOn visa avaliar três medicamentos antivirais reaproveitados: atazanavir, daclatasvir e sofosbuvir, já utilizados em pacientes infectados pelo HIV ou pelo vírus da hepatite C, em um estudo randomizado, controlado por placebo, adaptativo, multibraço e em múltiplos estágios. Os medicamentos serão testados simultaneamente em um ensaio de Fase II para primeiro identificar se algum deles, isoladamente ou em combinação, reduz a carga viral. Se reduzirem, será iniciado um estudo de Fase III para investigar se tais medicamentos são capazes de aumentar o número de dias sem suporte respiratório. Os participantes devem ser adultos hospitalizados com idade ≥ 18 anos com início dos sintomas ≤ 9 dias e saturação de oxigênio ≤ 94% em ar ambiente ou necessidade de oxigênio suplementar para manter saturação de oxigênio > 94%. O tamanho total esperado da amostra varia entre 252 e 1.005 participantes, dependendo do número de estágios que serão concluídos no estudo. Assim, o protocolo é aqui descrito em detalhes, juntamente do plano de análise estatística. Em conclusão, o estudo REVOLUTIOn foi concebido para fornecer evidências se o atazanavir, o daclatasvir ou o sofosbuvir reduzem a carga viral de SARS-CoV-2 em pacientes com COVID-19 e aumentam o número de dias em que os pacientes ficam sem suporte respiratório. Neste artigo de protocolo, descrevem-se a fundamentação, o desenho e a situação do ensaio. Identificador do ClinicalTrials.gov:NCT04468087

ABSTRACT Repurposed drugs are important in resource-limited settings because the interventions are more rapidly available, have already been tested safely in other populations and are inexpensive. Repurposed drugs are an effective solution, especially for emerging diseases such as COVID-19. The REVOLUTIOn trial has the objective of evaluating three repurposed antiviral drugs, atazanavir, daclatasvir and sofosbuvir, already used for HIV- and hepatitis C virus-infected patients in a randomized, placebo-controlled, adaptive, multiarm, multistage study. The drugs will be tested simultaneously in a Phase II trial to first identify whether any of these drugs alone or in combination reduce the viral load. If they do, a Phase III trial will be initiated to investigate if these medications are capable of increasing the number of days free respiratory support. Participants must be hospitalized adults aged ≥ 18 years with initiation of symptoms ≤ 9 days and SpO2 ≤ 94% in room air or a need for supplemental oxygen to maintain an SpO2 > 94%. The expected total sample size ranges from 252 to 1,005 participants, depending on the number of stages that will be completed in the study. Hence, the protocol is described here in detail together with the statistical analysis plan. In conclusion, the REVOLUTIOn trial is designed to provide evidence on whether atazanavir, daclatasvir or sofosbuvir decrease the SARS-CoV-2 load in patients with COVID-19 and increase the number of days patients are free of respiratory support. In this protocol paper, we describe the rationale, design, and status of the trial. ClinicalTrials.gov identifier:NCT04468087

Abstract: This study aimed to describe the telediagnosis of oral lesions through a telehealth program offered in the State of Paraná, southern Brazil. This report included all oral medicine-related teleconsultations between January 2015 and December 2019. Primary care dentists from the public health services of the state were trained to use the Telessaúde Brasil Redes platform, a national telehealth program that provides telediagnostic support through teleconsultations with specialists. Clinical information and images of oral lesions were solicited to each teleconsultation request. An oral medicine specialist evaluated the cases and provided diagnostic hypotheses, management, and referral suggestions. Finally, dentists were invited to evaluate the services. A total of 162 cases were submitted by 44 dentists. The patient's main complaint was described in 98.8% of cases, while the duration/evolution and the type of lesions were 64.81% and 40.12%, respectively. No images were attached to 19 (11.70%) patients. The information sent was sufficient for diagnostic reasoning in 125 (77.16%) requests. The specialist considered 78 cases (48.1%) to be resolved in primary care. Among respondents (45.7%), dentists considered that the teleconsultation “totally attended” their needs in 92% of requests. The description of the telehealth platform usage in oral medicine in Paraná showed the need to improve the participation of primary care dentists and the quality of clinical information provided as barriers to be overcome, aiming for the best usage of the platform.

RESUMO Objetivo A síndrome de burnout é definida como um fenômeno psicossocial em resposta crônica aos estressores interpessoais no ambiente de trabalho. Avaliar a síndrome de burnout em docentes dos cursos da área de saúde. Método Estudo descritivo, transversal, com abordagem quantitativa. Para coleta de dados foi utilizado o Maslach Burnout Inventory, além de um questionário socioeconô-mico. Utilizou-se do teste exato de Fisher para verificar se existe associação entre as variáveis sociodemográficas e a presença de burnout. Resultados Participaram do estudo 57 docentes, a maior parte do sexo feminino (n=39; 68,4%) e com tempo de atuação profissional acima de 10 anos (n=30; 52,6%). A maioria possui outro vinculo (n=43; 75,4%) e dedica mais de 40 horas semanais ao trabalho (n=35; 61,4%). A variável lazer apresentou-se estatisticamente significante em relação a ter ou não burnout evidenciando maior proporção de adoecimento entre os que referiram não sair a lazer. Observou-se percentuais elevados de exaustão emocional, despersonalização e baixa realização profissional revelando uma alta prevalência da síndrome de burnout entre os docentes. Conclusão Esses achados merecem atenção para o acompanhamento dos fatores psicossociais e organizacionais do processo laboral que possam intervir na qualidade de vida e nas condições de saúde desse trabalhador.

RESUMEN Objetivo El síndrome de burnout se define como un fenómeno psicosocial en respuesta crónica a estresores interpersonales en el lugar de trabajo. Valorar el síndrome de burnout en profesores de cursos del área de la salud. Método Estudio descriptivo, transversal con enfoque cuantitativo. Para la recolección de datos se utilizó el Inventario de Burnout de Maslach, además de un cuestionario socioeconómico. Se utilizó la prueba exacta de Fisher para verificar si existe asociación entre las variables sociodemográficas y la presencia de burnout. Resultados Participaron 57 profesores, la mayoría mujeres (n=39; 68,4%) y con más de 10 años de experiencia profesional (n=30; 52,6%). La mayoría tenía otro vínculo (n=43; 75,4%) y dedicaba más de 40 horas semanales al trabajo (n=35; 61,4%). La variable ocio resultó estadísticamente significativa en relación con tener burnout o no tenerlo, mostrando una mayor proporción de enfermedad entre quienes informaron no salir por ocio. Se observaron altos porcentajes de agotamiento emocional, despersonalización y baja realización profesional, revelando una alta prevalencia del síndrome de burnout entre los docentes. Conclusión Estos hallazgos merecen atención para monitorear los factores psicosociales y organizacionales del proceso de trabajo que pueden afectar la calidad de vida y las condiciones de salud de estos trabajadores.

ABSTRACT Objective To analyze the burnout syndrome in professors of health courses. Method It is a descriptive, cross-sectional study with a quantitative approach. For data collection were used the Maslach Burnout Inventory, in addition, a socioecono-mic questionnaire. That was used Fisher's exact test to verify the association between sociodemographic variables and the presence of Burnout. Results 57 college professors participated in the study, most of them female (n=39; 68.4%) and with professional experience over 10 years (n=30; 52.6%). Most have ano-ther job (n=43; 75.4%) and devote more than 40 hours a week to work (n=35; 61.4%). The leisure variable is shown to be statistically significant in relation to have burnout or not, showing the highest proportion of problems among those who refer to not leaving leisure. High percentages of emotional exhaustion, depersonalization, and low professional achievement were observed, revealing a high prevalence of burnout syndrome between the professors. Conclusion These findings deserve attention for monitoring psychosocial and organizational factors in the work process that may interfere with the quality of life and the health conditions of this worker.

resumo Este estudo objetivou atualizar a revisão do documento Report Card do Brasil, sobre a prevalência de atividade física (AF) global entre crianças e adolescentes brasileiros. A revisão sistemática incluiu uma busca eletrônica em 8 bases de dados (PubMed, Scopus, Web of Science, LILACS, SPORTDiscus, BIREME, Scielo e Google Scholar) e uma busca manual nas referências de estudos recuperados. Estudos publicados em 2018 e 2019 e que avaliaram a AF global entre jovens brasileiros foram incluídos na atualização. Uma abordagem narrativa em relação aos resultados foi adotada. A busca inicial atingiu 1892 títulos potencialmente relevantes (1244 títulos após análise duplicada); 62 (47 estudos diferentes) preencheram todos os critérios de inclusão. A maioria dos estudos da atualização foi realizada nas regiões Sul (40.4%) e Sudeste (25.5%) do Brasil. Seis estudos trouxeram dados sobre levantamentos nacionais (12,8%), e um estudo incluiu crianças pré-escolares (< 5 anos de idade). Dez estudos realizaram a medida objetiva de AF (acelerômetros ou pedômetros). Nos estudos da atualização, a proporção geral de jovens que eram fisicamente ativos variou de 9,8% a 79,6%. Três pesquisas nacionais relataram a prevalência de estudantes fisicamente ativos, variando de 18,4% a 78,8%. Observou-se um avanço nos levantamentos com medidas objetivas de AF e com crianças menores de 12 anos de idade com os estudos de 2018 e 2019. Contudo, lacunas importantes de pesquisa (p.ex., variações na mensuração da AF global até no mesmo estudo) devem ser consideradas para aprimorar o monitoramento e a avaliação da AF global no Brasil.

abstract This study aimed to update the review of Brazil’s Report Card on the prevalence of global physical activity (PA) among Brazilian children and adolescents. This systematic review included an electronic search of eight databases (PubMed, Scopus, Web of Science, LILACS, SPORTDiscus, BIREME, Scielo, and Google Scholar) and a manual search of the references of retrieved studies. Studies published in 2018 and 2019 that assessed global PA among Brazilian youth were included. A narrative approach to the results was adopted. The initial search retrieved 1,892 potentially relevant titles (1,244 titles after duplicate analysis), of which 62 (47 different studies) met all the inclusion criteria. Most updated studies were carried out in Southern (40.4%) and Southeastern (25.5%) Brazil. Six studies provided data from national surveys (12.8%), and one study included preschool children (< 5 years old). Ten studies objectively measured PA (accelerometer or pedometer devices). In the updated studies, the overall proportion of young people who were physically active ranged from 9.8% to 79.6%. Three national surveys reported the prevalence of physically active students, ranging from 18.4% to 78.8%. There was an increase of surveys that objectively measured PA and with children under 12 years of age in the 2018 and 2019 studies. However, important research gaps (e.g., variations in the measurement of global PA), even in the same study, should be considered to improve the monitoring and evaluation of global PA in Brazil.

RESUMO: O uso de sementes com bom potencial sanitário e fisiológico garante o estabelecimento da cultura, com estande de plântulas uniformes, vigorosas e livres de doenças, que consequentemente resultará em bons níveis de produtividade. Diante do exposto, objetivou-se avaliar a qualidade sanitária e fisiológica de sementes de milho roxo (Zea mays L.) submetidas à termoterapia, por meio de tratamento térmico com imersão em água destilada esterilizada (ADE), aquecida à temperatura de 50, 60 e 70 °C por 1, 2 e 3 minutos. O controle (0 min) correspondeu apenas à imersão das sementes em ADE. As sementes foram submetidas aos testes de sanidade e germinação em delineamento experimental inteiramente randomizado em esquema fatorial 3 × 3 + 1 (tempo de exposição × temperatura + controle adicional). Os dados foram submetidos à análise de variância e as médias foram comparadas pelo teste de Scott-Knott até 5% de probabilidade, com o auxílio do programa estatístico SISVAR®. A imersão das sementes de Zea mays em água quente a 50, 60 e 70 °C durante 1, 2 e 3 minutos é eficiente para impedir o aumento da incidência de Aspergillus sp., Penicillium sp. e Fusarium sp. O tratamento térmico a 60 °C por 1 e 2 minutos de imersão reduz a incidência da micoflora fúngica, sem prejudicar a qualidade fisiológica das sementes.

ABSTRACT: The use of seeds with good sanitary and physiological potential ensures the establishment of the crop, with a uniform, vigorous and disease-free seedling stand, which will result in good productivity levels. Seen that, the objective was to evaluate the sanitary and physiological quality of purple corn seeds (Zea mays L.) submitted to thermotherapy. They were subjected to heat treatment with immersion in sterile distilled water (SDW) heated at 50, 60 and 70 °C for 1, 2, and 3 minutes. The control (0 min) correspondens only to immersing the seeds in SDW, which were submitted to sanitary and germination tests in a completely randomized experimental design, in a factorial arrangement 3 × 3 + 1 (exposure time × temperature + additional control). Data were subjected to analysis of variance, and the means were compared with the Scott-Knott test up to 5% of probability, with the aid of the statistical program SISVAR®. Immersing Zea mays seeds in hot water at 50, 60 and 70 °C for 1, 2, and 3 minutes is efficient to prevent the increased incidence of Aspergillus sp., Penicillium sp., and Fusarium sp. The heat treatment at 60 °C for 1 and 2 minutes of immersion reduces the incidence of fungal mycoflora without impairing the physiological quality of seeds.

Noncolorectal gastrointestinal (GI) malignancies are among the most frequently diagnosed cancers. Despite the undeniable progress in systemic treatments in recent decades, further improvements using cytotoxic chemotherapy seem unlikely. In this setting, recent discoveries regarding the mechanism underlying immune evasion have prompted the study of molecules capable of inducing strong antitumor responses. Thus, according to early data, immunotherapy is a very promising tool for the treatment of patients with GI malignancies. Noncolorectal GI cancers are a major public health problem worldwide. Traditional treatment options, such as chemotherapy, surgery, radiation therapy, monoclonal antibodies and antiangiogenic agents, have been the backbone of treatment for various stages of GI cancers, but overall mortality remains a major problem. Thus, there is a substantial unmet need for new drugs and therapies to further improve the outcomes of treatment for noncolorectal GI malignancies. “Next-generation” immunotherapy is emerging as an effective and promising treatment option in several types of cancers. Therefore, encouraged by this recent success, many clinical trials evaluating the efficacy of immune checkpoint inhibitors and other strategies in treating noncolorectal GI malignancies are ongoing. This review will summarize the current clinical progress of modern immunotherapy in the field of noncolorectal GI tumors.

Introduction: schistosomiasis is kept under epidemiolotical surveillance in some areas of Brazil. Objective: to evaluate the epidemiological situation of schistosomiasis in the city of Belo Horizonte in Minas Gerais, Brazil, through epidemiological indicators. Methods: a descriptive study was conducted by using the System of Information and Notification of Grievances (SINAN) that contains the cases occurred in the residents of Belo Horizonte in the period of January-2007 to July-2011. Four hundred ninety six lab confirmed cases of schistosomiasis(Kato-Katz technique) were recorded. Results: in this period, there was a considerable increase of the number of cases in 2007 when the incidence was 1.96/100 000 habitants; the incidence was 7.29/100 000 habitants until July, 2011. Conclusions: the increasing number of recent cases points to the need of developing new strategies to control this endemic disease in our region.

Introducción: la esquistosomiasis mantiene una situación de atención epidemiológica en algunas zonas de Brasil. Objetivo: conocer la situación epidemiológica de la esquistosomiasis en la ciudad de Belo Horizonte, mediante indicadores epidemiológicos. Métodos: se hizo un estudio de carácter descriptivo, se utilizó como instrumento el sistema de información y los errores de notificación de los residentes de casos en Belo Horizonte, Estado de Minas Gerais en Brasil, en el período de enero de 2007 a julio de 2011; se registraron 496 casos de esquistosomiasis, confirmada por el criterio de laboratorio (técnica Kato-Katz). Resultados: se observó que en este período hubo un aumento considerable de casos en 2007, la incidencia fue de 1,96/100 000 habitantes; en 2011, hasta el mes de julio resultó de 7,29/100 000 habitantes. Conclusiones: el creciente número de casos recientes hace pensar en la necesidad del desarrollo de nuevas estrategias, para el control de esta enfermedad endémica que continúa en la región.