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au:Silva, Tania Maria Sarmento

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TANINOS E FLAVONOIDES DAS FLORES DE EUGENIA UNIFLORA (MYRTACEAE)
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Souza, Patricia Santana Oliveira de

; Santos, Micheline Thais dos Monteiro, Rejane Gonçalves Espindola, Maria Tamires Alves Souza, Helter José Silva de Monteiro, Amanda Lins Bispo Camara, Celso de Amorim Silva, Tania Maria Sarmento

Química Nova

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Set 2022, Volume 45 Nº 9 Páginas 1083 - 1091

Resumo: Pt | Texto: Pt | PDF: Pt

Eugenia uniflora, popularly known as pitanga, is a native species of the Brazilian flora, widely used in folk medicine for the treatment of various diseases and which has several bioactive chemical constituents. The aim of this work was to analyze the chemical composition of flowers visited by bees from Eugenia uniflora by Ultra-Performance Liquid Chromatography coupled with a Diode Array Detector and quadrupole Time of Flight Mass Spectrometry (UPLC-DAD-qTOF-MS/MS). Forty-four compounds were tentatively identified, including quinic acid, seven tannins and thirty-six flavonoids.

https://doi.org/10.21577/0100-4042.20170920

Pollen profile of bee pollen from semiarid Northeastern Brazil
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Karam, Viviane Miranda

; Silva, Tania Maria Sarmento

; Santos, Francisco de Assis Ribeiro dos

Acta Botanica Brasilica

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2022, Volume 36 elocation e20220205

Resumo: En | Texto: En | PDF: En

ABSTRACT The Northeastern Brazil has xerical vegetation with different biomes. Its botanical heterogeneity represents shelter for diverse fauna. The region is rich in bees, which demand the resources offered by the plants, and provide pollination services. Bee pollen has been used as a beneficial food source for humans due to its high nutritional content and being a natural antioxidant. Pollen analysis can determine the plant species visited by bees, using them as the source of pollen supply. This study aimed to identify the main pollen types present in the pollen collected by Apis mellifera in the Northeastern Brazil and to define its botanical affinity. Commercial bee pollen samples produced in the region were treated by acetolysis method, mounted on slides, and the frequency of occurrence was estimated for each type of pollen. It was possible to distinguish 113 pollen types belonging to 35 botanical families, distributed in 92 genera. Fabaceae and Asteraceae were the families that most contributed to pollen types. Pollen types of Cocos nucifera and Myrcia were found in more than 50% of the samples. The families Arecaceae and Fabaceae showed high beekeeping potential. There is a striking similarity between the pollen samples from the states of Pernambuco and Rio Grande Norte.

https://doi.org/10.1590/1677-941x-abb-2022-0205

PALYNOLOGICAL ORIGIN, PHENOLIC CONTENT AND ANTIOXIDANT PROPERTIES OF GEOPROPOLIS COLLECTED BY MANDAÇAIA (MELIPONA MANDACAIA) STINGLESS
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SILVA, PAULO RICARDO DA

; SILVA, TELMA MARIA GUEDES DA

; CAMARA, CELSO AMORIM

; SILVA, EVA MÔNICA SARMENTO DA

; SANTOS, FRANCISCO DE ASSIS RIBEIRO DOS

; SILVA, TANIA MARIA SARMENTO

Revista Caatinga

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Mar 2020, Volume 33 Nº 1 Páginas 246 - 252

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A abelha sem ferrão Melipona mandacaia (Smith 1863) (mandaçaia) é encontrada apenas na região da Caatinga, Nordeste do Brasil, nos estados da Bahia e Pernambuco, próximo ao rio São Francisco. O objetivo do presente trabalho foi determinar a origem botânica e avaliar o conteúdo fenólico e as propriedades antioxidantes (sistema β-caroteno / ácido linoléico, DPPH e sequestro do ABTS) da geopropolis da mandaçaia. Foram identificados 25 tipos polínicos de 15 famílias das 9 amostras de geoprópolis analisadas. O teor de compostos fenólicos variou entre todos os extratos etanólicos e as frações hexano, EtOAc e MeOH:H2O de geoprópolis. Os principais polens encontrados nas amostram de geopropolis foram da família Leguminoseae. Esta identificação de plantas utilizadas pelas meliponas indicam a importancia destas espécies vegetais como fontes de nectar e pólen. Nossos resultados revelaram que existe uma forte relação entre os compostos fenólicos e a atividade antioxidante. Estes resultados mostram que os fenóis totais da geoprópolis de mandaçaia foram responsáveis pela atividade antioxidante, com evidências de que é uma fonte rica de compostos bioativos fenólicos com potenciais benefícios a saúde.

ABSTRACT The stingless bee Melipona mandacaia (Smith 1863) (mandaçaia) is found only in the region of Caatinga, Northeastern Brazil, in the states of Bahia and Pernambuco, near to São Francisco river. The aim of the present work was to determine the botanical origin and to evaluate the phenolic content and antioxidant properties (β-carotene/linoleic acid system, DPPH and ABTS scavenging) of mandaçaia geopropolis. 25 pollen types from 15 families were identified from the 9 geopropolis samples analyzed. Phenolic compounds content varied between all the geopropolis EtOH extracts, hexane, EtOAc and MeOH:H2O fractions. The main pollens found in the geopropolis samples were from the Leguminoseae family. This identification of meliponicultural plants is extremely important because it indicates the food sources used for the collection of nectar and pollen. Our results revealed that there is a strong relation between the phenolic compounds and the antioxidant activity. These results showed that total phenols of mandaçaia geopropolis may be responsible for the antioxidant activity with evidence that it's a rich source of phenols bioactive compounds with potential health benefits.

https://doi.org/10.1590/1983-21252020v33n126rc 589 downloads

Geopropolis gel for the adjuvant treatment of candidiasis – formulation and in vitro release assay
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Souza Júnior, Umberto Pereira

; Cabrera, Sonia Pereira

; Silva, Telma Maria Guedes da

; Silva, Eva Monica Sarmento da

; Camara, Celso Amorim

; Silva, Tania Maria Sarmento

Revista Brasileira de Farmacognosia

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Jun 2019, Volume 29 Nº 3 Páginas 278 - 286

Resumo: En | Texto: En | PDF: En

ABSTRACT The geopropolis produced by the stingless bee Melipona subnitida (popularly called "jandaíra" in Brazil) is a mixture of resin, wax, and mud. This study analyzed the antifungal activity of the geopropolis extract from Candida spp., developed a gel formulation with this extract and analyzed the delivery of bioactives (kinetics release) in the formulation and their chemical profile by UHPLC-PDA-qTOF-MS/MS. Three different gels were prepared using the geopropolis extract, carbomer, propylene glycol, and water. Formulations with different amounts of propylene glycol were investigated. Physical, visual, pH, viscosity, adhesion, spreadability, leakage, and in vitro release tests were performed in the proposed formulations. Antifungal tests with the geopropolis ethanolic extract were carried out against six Candida species. The chemical profile of the geopropolis extract and compounds released from the formulations were analyzed after the release test. The formulations had a pH between 4.6 and 4.8 and viscosity between 535,600 and 920,400 cPs. The geopropolis extract presented excellent antifungal activity against the tested yeasts. The results of the release test in semipermeable cellulose membrane showed that all formulations containing 5%, 10% and 40% propylene glycol presented release of geopropolis extract. For adhesion and leakage tests, the gel formulation with 5% propylene glycol was more effective. Both geopropolis ethanolic extract and the liquid obtained in the release test showed the presence of flavonoids (flavonol/flavone, flavanone, and chalcones). Gel formulations with geopropolis extract that are rich in flavonoids are promising as an adjuvant treatment of vaginal candidiasis.

https://doi.org/10.1016/j.bjp.2019.02.010 461 downloads

ANTIMICROBIAL ACTIVITY OF ETHANOLIC EXTRACTS FROM Commiphora leptophloeos (MART.) J. B. GILLETT AGAINST Staphylococcus SPP. ISOLATED FROM CASES OF MASTITIS IN RUMINANTS
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Silva, Isamara Ferreira da

; Guimarães, Amanda Leite

; Amorim, Vinícius Santana

; Silva, Telma Maria Guedes da

; Peixoto, Rodolfo de Moraes

; Nunes, Xirley Pereira

; Silva, Tânia Maria Sarmento

; Costa, Mateus Matiuzzi da

Ciência Animal Brasileira

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2019, Volume 20 elocation e57228

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Considerando o potencial terapêutico de plantas medicinais como alternativas à antibioticoterapia, a pesquisa visa avaliar a atividade antimicrobiana de Commiphora leptophloeos contra isolados de Staphylococcus spp. de leite de ruminante com mastite subclínica. Para isso, foi elaborado o extrato etanólico bruto da casca e folhas de Commiphora leptophloeos, sendo as mesmas caracterizadas quimicamente por HPLC-DAD-MS e por MALDI-TOF. Os extratos foram então avaliados quanto aos seus efeitos antimicrobianos contra 60 isolados de Staphylococcus spp pela técnica de microdiluição em caldo para determinação da concentração bactericida mínima. Além disso, os extratos foram avaliados quanto à sua capacidade de interferir na formação do biofilme e com o biofilme já consolidado. Apesar de todos os extratos testados terem apresentado ação antimicrobiana, valores menores de CBM foram registrados para o extrato da casca na concentração 781,2 µg/mL (25/60). Os extratos da casca e das folhas foram capazes de interferir nos estágios iniciais da formação do biofilme, mas não ocorreu interferência do extrato no biofilme consolidado. Houve alta sensibilidade do isolados testados quando submetidos a extratos de folhas e casca de Commiphora leptophloeos, bem como a capacidade de extratos interferirem na formação de biofilme, indicando seu potencial uso na terapia de mastite de ruminantes.

Abstract Considering the therapeutic potential of medicinal plants as alternatives to antibiotic therapy, the research aims to evaluate the antimicrobial activity of Commiphora leptophloeos against isolates of Staphylococcus spp. from the milk of ruminants with subclinical mastitis. For this, the crude ethanolic extract from the bark and leaves of Commiphora leptophloeos was prepared, with these being chemically characterized by HPLC-DAD-MS and by MALDI-TOF. The extracts were then evaluated as to their antimicrobial effects against 60 isolates of Staphylococcus spp. through the broth microdilution technique to determine the minimum bactericidal concentration. In addition, the extracts were evaluated as to their ability to interfere with biofilm formation and with the already established biofilm. Although all tested extracts showed antimicrobial action, lower MBC values were recorded for the bark extract in the concentration 781.2 µg/mL (25/60). The extracts of the bark and leaves were able to interfere with the initial stages of biofilm formation, but there was no interference of the extract on the established biofilm. There was a high sensitivity of Staphylococcus spp. isolates from subclinical mastitis cases in ruminants when subjected to the extracts from bark and leaves of Commiphora leptophloeos, as well as regarding the ability of extracts to interfere in biofilm formation, indicating their potential in the use for ruminant mastitis therapy.

https://doi.org/10.1590/1089-6891v20e-57228 832 downloads

PHYTOCHEMISTRY INVESTIGATION OF CASEARIA ARBOREA (RICH.) URB. (SALICACEAE) AND ANTIMICROBIAL ANALYSIS OF ITS DITERPENE
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Leite-Ferreira, Maria D. Rocha-Souza, Maria S. Ramirez, Raphael R. de A. Chaves, Otemberg S. Teles, Yanna C. F. Pereira, Fillipe de O. Braz-Filho, Raimundo Lima, Edeltrudes de O. Sarquis, Rosangela do Socorro F. R. Silva, Tânia Maria Sarmento da Souza, Maria de Fátima Vanderlei de

Química Nova

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Jun 2018, Volume 41 Nº 6 Páginas 619 - 622

Resumo: En | Texto: En | PDF: En

A phytochemical investigation from aerial parts of Casearia arborea (Rich.) Urb. (Salicaceae) led to isolation and identification of: sitosterol, 4-en-stigmast-3-one, 13-hydroxy-trans-ent-cleroda-3,14-diene,3-hydroxy-2-oxo-trans-ent-cleroda-3,14-diene (kolavelone), a mixture of 13-hydroxy-trans-ent-cleroda-3,14-diene and an ester ethyl hexadecanoate, kaempferol-3-O-a-L-arabinofuranoside and 4',5,7-trihydroxy-3',5'-dimethoxyflavone (tricin). The compounds have been described for the first time in this species. Five trihydroxy-flavone-hexoside derivatives have been identified by LC-ESI-HR-MS. The antimicrobial activity of kolavelone was evaluated against strains of Staphylococcus, Bacillus, Pseudomonas, Shigella and Candida spores, and its minimum inhibitory concentration (MIC) was determined. The results showed the antimicrobial activity of kolavelone against several bacteria and Candida tropicalis indicating its potential use as antimicrobial agent.

https://doi.org/10.21577/0100-4042.20170220 669 downloads

Brazilian guidelines for the diagnosis and treatment of cystic fibrosis
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Athanazio, Rodrigo Abensur Silva Filho, Luiz Vicente Ribeiro Ferreira da Vergara, Alberto Andrade Ribeiro, Antônio Fernando Riedi, Carlos Antônio Procianoy, Elenara da Fonseca Andrade Adde, Fabíola Villac Reis, Francisco José Caldeira Ribeiro, José Dirceu Torres, Lídia Alice Fuccio, Marcelo Bicalho de Epifanio, Matias Firmida, Mônica de Cássia Damaceno, Neiva Ludwig-Neto, Norberto Maróstica, Paulo José Cauduro Rached, Samia Zahi Melo, Suzana Fonseca de Oliveira Pinto, Leonardo Araújo Monte, Luciana Freitas Velloso Higa, Laurinda Yoko Shinzato Folescu, Tania Wrobel Marson, Fernando Augusto de Lima Sad, Isabela Servidoni, Maria de Fátima Correa Pimenta Kussek, Paulo Raskin, Salmo Zuana, Adriana Della Augustin, Albin Hoffmann, Anneliese Barbisan, Beatriz Hochhegger, Bruno Levy, Carlos Emilio Veiga, Claudine Sarmento da Ricachinevsky, Claudio Esposito, Concetta Escuissato, Dante Brandemburgo, Diego Marques, Elisabeth Aquino, Evanirso de Fischer, Gilberto Bueno Rodrigues, Joaquim Carlos Machado, Leticia Muramato, Lucia Costa, Lusmaia Damasceno Camargo Donadio, Marcio Castro, Marcos César Santos de Ribeiro, Maria Angela Santana, Maria Angélica Canan, Mariane Almeida, Marina Buarque de Britto, Murilo Dalcin, Paulo Roth Tarso Ramos, Regina Terse Trindade Chiba, Sonia Martins, Valéria de Carvalho Lacerda, Claudine Barbosa, Eliana Guimarães, Elizabet Vilar Hessel, Gabriel Gurmini, Jocemara Neri, Lenycia Nogueira, Marcelo Coelho Wayhs, Mônica Chang Simon, Miriam Isabel Santos Fernandes, Arlene Gonçalves dos Santos Silva, Claudia de Castro de Albuquerque, Cristiano Túlio Maciel Souza, Edna Lúcia Silva, Fernando Antonio de Abreu e Dalcin, Paulo de Tarso Noronha, Renata Maria de Teixeira, Ricardo Machado, Sandra Helena Camargo, Spencer Marcantonio Rozov, Tatiana Rodrigues, Ticiana da Costa

Jornal Brasileiro de Pneumologia

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Jun 2017, Volume 43 Nº 3 Páginas 219 - 245

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A fibrose cística (FC) é uma doença genética autossômica recessiva caracterizada pela disfunção do gene CFTR. Trata-se de uma doença multissistêmica que ocorre mais frequentemente em populações descendentes de caucasianos. Nas últimas décadas, diversos avanços no diagnóstico e tratamento da FC mudaram drasticamente o cenário dessa doença, com aumento expressivo da sobrevida e qualidade de vida. Atualmente, o Brasil dispõe de um programa de ampla cobertura para a triagem neonatal de FC e centros de referência distribuídos na maior parte desses estados para seguimento dos indivíduos. Antigamente confinada à faixa etária pediátrica, tem-se observado um aumento de pacientes adultos com FC tanto pelo maior número de diagnósticos de formas atípicas, de expressão fenotípica mais leve, assim como pelo aumento da expectativa de vida com os novos tratamentos. Entretanto, ainda se observa uma grande heterogeneidade no acesso aos métodos diagnósticos e terapêuticos para FC entre as diferentes regiões brasileiras. O objetivo dessas diretrizes foi reunir as principais evidências científicas que norteiam o manejo desses pacientes. Um grupo de 18 especialistas em FC elaborou 82 perguntas clínicas relevantes que foram divididas em cinco categorias: características de um centro de referência; diagnóstico; tratamento da doença respiratória; tratamento gastrointestinal e nutricional; e outros aspectos. Diversos profissionais brasileiros atuantes na área da FC foram convidados a responder as perguntas formuladas pelos coordenadores. A literatura disponível foi pesquisada na base de dados PubMed com palavras-chave, buscando-se as melhores respostas às perguntas dos autores.

ABSTRACT Cystic fibrosis (CF) is an autosomal recessive genetic disorder characterized by dysfunction of the CFTR gene. It is a multisystem disease that most often affects White individuals. In recent decades, various advances in the diagnosis and treatment of CF have drastically changed the scenario, resulting in a significant increase in survival and quality of life. In Brazil, the current neonatal screening program for CF has broad coverage, and most of the Brazilian states have referral centers for the follow-up of individuals with the disease. Previously, CF was limited to the pediatric age group. However, an increase in the number of adult CF patients has been observed, because of the greater number of individuals being diagnosed with atypical forms (with milder phenotypic expression) and because of the increase in life expectancy provided by the new treatments. However, there is still great heterogeneity among the different regions of Brazil in terms of the access of CF patients to diagnostic and therapeutic methods. The objective of these guidelines was to aggregate the main scientific evidence to guide the management of these patients. A group of 18 CF specialists devised 82 relevant clinical questions, divided into five categories: characteristics of a referral center; diagnosis; treatment of respiratory disease; gastrointestinal and nutritional treatment; and other aspects. Various professionals working in the area of CF in Brazil were invited to answer the questions devised by the coordinators. We used the PubMed database to search the available literature based on keywords, in order to find the best answers to these questions.

https://doi.org/10.1590/s1806-37562017000000065 75529 downloads

Spatial distribution of scorpions according to the socioeconomic conditions in Campina Grande,State of Paraíba, Brazil
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Almeida, Thassiany Sarmento Oliveira de Fook, Sayonara Maria Lia França, Francisco Oscar de Siqueira Monteiro, Tânia Maria Ribeiro Silva, Edwirde Luiz Gomes, Lidiane Cristina Félix Farias, Aline Maiara Galdino

Revista da Sociedade Brasileira de Medicina Tropical

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Ago 2016, Volume 49 Nº 4 Páginas 477 - 485

Resumo: En | Texto: En | PDF: En

Abstract: INTRODUCTION: Due to its frequency and morbidity, such as that caused by scorpions have achieved public health importance in certain regions of the world. The present exploratory ecological study aimed to characterize the epidemiological profile and spatial distribution of scorpion stings in Campina Grande, State of Paraíba in Northeastern Brazil. METHODS: Geographical information system techniques were used to record the scorpion stings, and Google Earth software, Track Maker, and ArcGIS 10 Esri were used as geocoding databases. The Moran test was used to evaluate spatial correlation, and the Pearson chi-square test was used to analyze associations between scorpion stings and socioeconomic variables. RESULTS: The study evaluated 1,466 scorpion stings. Envenomations were more frequent among women (n = 908, 61.9%), and most patients were aged 13-28 years (n = 428, 29.2%). The Southern region of the city had the largest number of registered cases (n = 548, 37.4%), followed by the Western region (n = 510, 34.8%). CONCLUSIONS: Spatial analysis of scorpionism revealed an irregular occurrence in Campina Grande. Further, no association was observed between the socioeconomic factors analyzed and the geographic location of the scorpion envenomations. Detection of spatial areas with an increased risk of scorpionism can help prioritize adoption of preventive measures in these regions to reduce the associated incidence and morbidity.

https://doi.org/10.1590/0037-8682-0128-2016 1805 downloads

Isoflavone formononetin from red propolis acts as a fungicide against Candida sp
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Neves, Michelline Viviane Marques das Silva, Tânia Maria Sarmento da Lima, Edeltrudes de Oliveira Cunha, Emídio Vasconcelos Leitão da Oliveira, Eduardo de Jesus

Brazilian Journal of Microbiology

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Mar 2016, Volume 47 Nº 1 Páginas 159 - 166

Resumo: En | Texto: En | PDF: En

Abstract A bioassay-guided fractionation of two samples of Brazilian red propolis (from Igarassu, PE, Brazil, hereinafter propolis 1 and 2) was conducted in order to determine the components responsible for its antimicrobial activity, especially against Candida spp. Samples of both the crude powdered resin and the crude ethanolic extract of propolis from both locations inhibited the growth of all 12 tested Candida strains, with a minimum inhibitory concentration of 256 µg/mL. The hexane, acetate and methanol fractions of propolis 1 also inhibited all strains with minimum inhibitory concentration values ranging from 128 to 512 µg/mL for the six bacteria tested and from 32 to 1024 µg/mL for the yeasts. Similarly, hexane and acetate fractions of propolis sample 2 inhibited all microorganisms tested, with minimum inhibitory concentration values of 512 µg/mL for bacteria and 32 µg/mL for yeasts. The extracts were analyzed by HPLC and their phenolic profile allowed us to identify and quantitate one phenolic acid and seven flavonoids in the crude ethanolic extract. Formononetin and pinocembrin were the major constituents amongst the identified compounds. Formononetin was detected in all extracts and fractions tested, except for the methanolic fraction of sample 2. The isolated isoflavone formononetin inhibited the growth of all the microorganisms tested, with a minimum inhibitory concentration of 200 µg/mL for the six bacteria strains tested and 25 µg/mL for the six yeasts. Formononetin also exhibited fungicidal activity against five of the six yeasts tested. Taken together our results demonstrate that the isoflavone formononetin is implicated in the reported antimicrobial activity of red propolis.

https://doi.org/10.1016/j.bjm.2015.11.009 1714 downloads

10.

Ocorrência de biflavonoides em Clusiaceae: aspectos químicos e farmacológicos
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Ferreira, Rafaela Oliveira Carvalho, Mário Geraldo de Silva, Tania Maria Sarmento da

Química Nova

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2012, Volume 35 Nº 11 Páginas 2271 - 2277

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

This work describes the biflavonoids found in species of Clusiaceae, particularly the genera Garcinia and Calophyllum, emphasizing the importance of these metabolites as chemical markers of this family, their contribution to the pharmacological potential of these species, besides the promising potential of these compounds in the search for new drugs.

4080 downloads Citado 2 vezes em SciELO

11.

Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity
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Bezerra, Amanda de Melo Lins, Antônio Cláudio da Silva Athayde-Filho, Petrônio Filgueiras de Silva, Marcelo Sobral da Barbosa-Filho, José Maria Camara, Celso Amorim Silva, Tania Maria Sarmento Luna, Vanessa da Silva Santos, Creusioni Figueredo dos

Química Nova

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2012, Volume 35 Nº 11 Páginas 2226 - 2228

Resumo: En | Texto: En | PDF: En

Seven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA. All compounds tested showed strong inhibition at a concentration of 100 µM, while none showed activity between 5 and 70 µM. These results indicate that no obvious correlation can be derived between the structure of these compounds and their inhibitory effect on the DNA relaxation activity of topoisomerase II. This is the first report on DNA topoisomerase II inhibitors from Licaria chrysophylla and Licaria aurea leading to the identification of lignoids as topoisomerase II-α inhibitors.

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12.

Phaeophytins from Thyrsacanthus ramosissimus Moric. with inhibitory activity on human dna topoisomerase II-α
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Cabral, Analúcia Guedes Silveira Tenório-Souza, Fábio Henrique Moura, Marcelo Dantas Mota, Sabrina Gondim Ribeiro Silva Lins, Antônio Cláudio da Dias, Celidarque da Silva Barbosa-Filho, José Maria Giulietti, Ana Maria Silva, Tania Maria Sarmento da Santos, Creusioni Figueredo dos

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2012, Volume 35 Nº 11 Páginas 2222 - 2225

Resumo: En | Texto: En | PDF: En

Our study reports the extraction and isolation of a new phaeophytin derivative 15¹-hydroxy-(15¹-S)-porphyrinolactone, designated anamariaine (1) herein, isolated from the chloroform fraction of aerial parts of Thyrsacanthus ramosissimus Moric. along with the known 15¹-ethoxy-(15¹-S)-porphyrinolactone (2). These compounds were identified by usual spectroscopic methods. Both compounds were subjected to in vitro (inhibitory activity) tests by means of supercoiled DNA relaxation techniques and were shown to display inhibitory activity against human DNA topoisomerase II-α at 50 µM. Interconversion of these two pigments under the mild conditions of the isolation techniques should be highly unlikely but cannot be entirely ruled out.

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13.

Feoforbídeo (etoxi-purpurina-18) isolado de Gossypium mustelinum (Malvaceae)
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Silva, Tania Maria Sarmento Camara, Celso Amorim Barbosa-Filho, José Maria Giulietti, Ana Maria

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2010, Volume 33 Nº 3 Páginas 571 - 573

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

The phaeophorbide ethyl ester named Purpurin-18 and the flavonoids quercetin and kaempferol were obtained by chromatographic procedures from the chloroform fraction of aerial parts of Gossypium mustelinum. The structure of these compound was determined by NMR, IR and mass spectra data analysis. This is the first occurrence of this compound in Angiosperm.

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14.

Estudo espectroscópico em elucidação estrutural de flavonoides de Solanum jabrense Agra & Nee e S. paludosum Moric
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Silva, Tania Maria Sarmento da Carvalho, Mario Geraldo de Braz-Filho, Raimundo

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2009, Volume 32 Nº 5 Páginas 1119 - 1128

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

The NMR (RMN¹H, 13C, COSY, HMQC, HMBC, NOE-DIFF, NOESY) and mass spectra data analysis of sixteen flavonoids, including nine natural, 7-O-methylkanferol (ramnocitrin), 3,7-di-O-methylkanferol (kumatakenin), 3-O-methylquercetin, 3,7,3',4'-tetra-O-methylquercetin (retusin), 3,7,8,4'-tetra-O-methylgossipetin, 3,7,8,3',4'-penta-O-methylgossipetin, 7-O-methylapigenin (genkwanin), 3,7,8-tri-O-methylherbacetin, 7,4'- di-O-methylquercetin (ombuine), isolated from Solanum paludosum and S. jabrense, and seven prepared methyl and acetyl derivatives, are discussed according the substitution on the rings A, B and C.

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15.

Constituintes químicos e atividade antioxidante de Sida galheirensiS Ulbr. (Malvaceae)
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Silva, Davi Antas e Silva, Tânia Maria Sarmento da Lins, Antônio Cláudio da Silva Costa, Danielly Albuquerque da Cavalcante, José Marcílio Sobral Matias, Wemerson Neves Souza, Maria de Fátima Vanderlei de Braz Filho, Raimundo

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Dez 2006, Volume 29 Nº 6 Páginas 1250 - 1254

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

The phytochemical investigation of Sida galheirensis led to the isolation of 5,4'-dihydroxy-3,7,3´-trimethoxyflavone, 17³-ethoxyphaeoforbide, a rare natural product, 6,7-dimethoxycoumarin, ortho-hydroxybenzoic acid, sitosterol-3-O-beta-D-glucopyranoside, stigmasterol-3-O-beta-D-glucopyranoside, 5,7,4'-trihydroxyflavone, 5,7,3',4'-tetrahydroxyflavone, kaempferol-3-O-beta-D-(6"-E-p-coumaroyl) glucopyranoside and luteolin 7-O-beta-D-glucopyranoside. Their structures were assigned based on spectroscopic analyses, including two-dimensional NMR techniques. Antioxidant activities of hexane, CHCl3, EtOAc, BuOH and EtOH extracts of Sida galheirensis were measured using the 1,2-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging assay. This is also the first work reporting the chemical investigation of Sida galheirensis.

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