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ABSTRACT Foundation: Innovative strategies include process management to prevent workers from being prone to difficulties in their performance due to the psychological impact. It is necessary for the administration to adopt learning processes for the development of social skills that allow the care of the mental health of workers and counteract the negative effect of the psychological impact. Objective: To determine the influence on the psychological impact of innovative strategies with social skills to care for mental health developed through inquiry learning in process management. Methods: The research had a cross-sectional, non-experimental design, with a descriptive and correlational scope and a quantitative approach. The sample was 64 workers from the deputy management of education, health and sports of a municipality. To collect information on the defined variables, questionnaires used in research carried out in Peru were used. The null hypothesis was: in the psychological impact does not influence the innovative strategies on process management of social skills acquired through inquiry learning to care for the mental health of workers in a municipality in Peru. Results: There was a relationship between the psychological impact and the innovative strategies on process management determined by the social skills acquired through inquiry learning to care for mental health; with a ratio of 0.86 and a significance level of 0.000. Conclusions: There is a high influence on the psychological impact of innovative strategies that include process management of social skills developed through inquiry learning to care for the mental health of workers.

RESUMEN Fundamento: Las estrategias innovadoras incluyen a la gestión por procesos para evitar que trabajadores resulten propensos a tener dificultades en su desempeño a causa del impacto psicológico. Resulta necesario que la administración adopte procesos de aprendizaje para el desarrollo de habilidades sociales que permitan el cuidado de la salud mental de los trabajadores y contrarrestar el efecto negativo del impacto psicológico. Objetivo: Determinar la influencia en el impacto psicológico de las estrategias innovadoras con habilidades sociales para cuidar la salud mental desarrolladas mediante el aprendizaje por indagación en la gestión por procesos. Métodos: Se realizó un estudio transversal, no experimental, con alcance descriptivo y correlacional y un enfoque cuantitativo. La muestra fue de 64 trabajadores de la subgerencia de educación, salud y deportes de una municipalidad. Para la recopilación de la información de las variables definidas se utilizaron cuestionarios empleados en investigaciones efectuadas en Perú. La hipótesis nula fue: no influye en el impacto psicológico las estrategias innovadoras que incluyen la gestión por procesos de habilidades sociales adquiridas mediante aprendizaje por indagación para cuidar la salud mental de los trabajadores de una municipalidad del Perú. Resultados: Existió una relación entre el impacto psicológico y las estrategias innovadoras que incluyen la gestión por procesos, determinada por las habilidades sociales adquiridas mediante el aprendizaje por indagación para cuidar la salud mental; con una relación de 0,86 y un nivel de significación de 0,000. Conclusiones: Existe alta influencia en el impacto psicológico de las estrategias innovadoras que incluyen a la gestión por procesos de las habilidades sociales desarrolladas mediante el aprendizaje por indagación para cuidar la salud mental de los trabajadores.

A synopsis of Tunicata biodiversity in Brazil
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Rocha, Rosana M.

; Lotufo, Tito Monteiro da Cruz

; Bonecker, Sergio

; Oliveira, Livia de Moura

; Skinner, Luis Felipe

; Carvalho, Pedro Freitas de

; Silva, Paulo Cezar Azevedo da

Zoologia (Curitiba)

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2024, Volume 41 elocation e23042

Resumo: En | Texto: En | PDF: En

ABSTRACT The Tunicata, despite the relatively low species diversity among the invertebrates, has always received attention not only due to their ecological importance, especially in fouling communities, but also for several species that are studied as models for genetics and the evolution of development, as well as being a prolific source of natural products. In Brazil, research during the last 60 years has considerably increased our knowledge of benthic and planktonic tunicates, resulting from the work of several research teams. In this review, we provide information on the biodiversity of coastal Brazil along with an analysis of geographic distribution, sampling effort, the locations and status of taxonomic collections, and research specialists working on this group. Tunicata invertebrates importance communities development products 6 tunicates teams review distribution effort collections group

https://doi.org/10.1590/s1984-4689.v41.e23042

Cotton incorporated Poly(lactic acid)/thermoplastic Starch Based Composites Used as Flexible Packing for Short Shelf Life Products Polylactic Poly lactic acid/thermoplastic acidthermoplastic acid /thermoplastic thermoplastic
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Silva, Luciano Figueiredo

; Silveira, Pedro Henrique Poubel Mendonça da

; Rodrigues, Ana Carolina Bastos

; Monteiro, Sergio Neves

; Santos, Shirleny Fontes

; Morais, João Paulo Saraiva

; Bastos, Daniele Cruz

Materials Research

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2024, Volume 27 elocation e20230366

Resumo: En | Texto: En | PDF: En

Biocomposites have gained attention in the packaging industry due to their potential as sustainable alternatives to conventional synthetic materials. In this study, novel cotton incorporated poly(lactic acid)/thermoplastic starch biocomposites were developed for packaging applications using in short shelf life products the extrusion method. Pelletized samples obtained by extrusion were stamped from plates obtained by compression and were characterized through measurement of density, hardness, contact angle and water absorption, as well as Fourier transform infrared spectroscopy (FTIR), thermal analysis and scanning electron microscopy (SEM). No significant changes in the density results were observed. A slight increase in the hardness of formulations in relation to the PLA was associated with the presence of cotton fiber in biocomposites. The FTIR results revealed physical interaction of PLA, TPS and cotton fiber. By DSC analysis, for all formulations the melting exhibited only one peak, suggesting good homogeneity and interaction among the components, as observed by TG/DTG results, and corroborating SEM analysis. The biocomposite PLA/TPS/Cotton 85/10/5 wt.% displayed greater increase in water absorption than both 95/5/0 and 90/5/5 wt.% formulations, which can be attributed to the increase in starch proportion, confirming the contact angle results. The hydrophilic tendency corroborated the biodegradation process in the packaging end-of-life. materials study polylactic poly lactic acid/thermoplastic acidthermoplastic acid /thermoplastic thermoplastic method FTIR, , (FTIR) SEM. . (SEM) peak components TGDTG TG DTG PLATPSCotton Cotton 85105 85 10 5 85/10/ wt wt. 9550 95 0 95/5/ 9055 90 90/5/ proportion endoflife. endoflife end life. end-of-life (FTIR (SEM 8510 8 1 85/10 955 9 95/5 905 90/5 851 85/1 95/ 90/ 85/

https://doi.org/10.1590/1980-5373-mr-2023-0366

Leishmania (Sauroleishmania) tarentolae versus pathogenic species: comparative evaluation of protease activity, glycoconjugates, resistance to complement and metabolome composition Sauroleishmania (Sauroleishmania species activity glycoconjugates
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Andrade, Filipe Fideles Duarte

; Vitório, Jéssica Gardone

; Canuto, Gisele André Baptista

; Nunes, Fernanda Freire Campos

; Rodrigues, Isabela Aurora

; Almeida, Ana Paula Martins Morais

; Nascimento, Frederico Crepaldi

; Costa, Adriana Oliveira

; Vieira, Tamara da Silva

; Silva, Ana Carolina Carvalho

; André, Leiliane Coelho

; Gontijo, Célia Maria Ferreira

; Junqueira, Caroline

; Toledo, Juliano Simões de

; Fernandes, Ana Paula

; Soares, Rodrigo Pedro

Memórias do Instituto Oswaldo Cruz

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2024, Volume 119 elocation e230243

Resumo: En | Texto: En | PDF: En

BACKGROUND Leishmania tarentolae is a non-pathogenic species found in lizards representing an important model for Leishmania biology. However, several aspects of this Sauroleishmania remain unknown to explain its low level of virulence. OBJECTIVES We reported several aspects of L. tarentolae biology including glycoconjugates, proteolytic activities and metabolome composition in comparison to pathogenic species (Leishmania amazonensis, Leishmania braziliensis, Leishmania infantum and Leishmania major). METHODS Parasites were cultured for extraction and purification of lipophosphoglycan (LPG), immunofluorescence probing with anti-gp63 and resistance against complement. Parasite extracts were also tested for proteases activity and metabolome composition. FINDINGS Leishmania tarentolae does not express LPG on its surface. It expresses gp63 at lower levels compared to pathogenic species and, is highly sensitive to complement-mediated lysis. This species also lacks intracellular/extracellular activities of proteolytic enzymes. It has metabolic differences with pathogenic species, exhibiting a lower abundance of metabolites including ABC transporters, biosynthesis of unsaturated fatty acids and steroids, TCA cycle, glycine/serine/threonine metabolism, glyoxylate/dicarboxylate metabolism and pentose-phosphate pathways. MAIN CONCLUSIONS The non-pathogenic phenotype of L. tarentolae is associated with alterations in several biochemical and molecular features. This reinforces the need of comparative studies between pathogenic and non-pathogenic species to elucidate the molecular mechanisms of virulence during host-parasite interactions. nonpathogenic non However L glycoconjugates amazonensis braziliensis major. major . major) LPG, , (LPG) antigp63 antigp anti gp anti-gp6 complement surface gp6 complementmediated mediated lysis intracellularextracellular intracellular extracellular enzymes transporters steroids cycle glycineserinethreonine glycine serine threonine glyoxylatedicarboxylate glyoxylate dicarboxylate pentosephosphate pentose phosphate pathways features hostparasite host parasite interactions (LPG antigp6 anti-gp

https://doi.org/10.1590/0074-02760230243

Memory complaint in a middle-income country: a four-year longitudinal study in a cohort with low-education middleincome middle income country fouryear four year loweducation low education
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Pereira, Marcos Leandro

; Caramelli, Paulo

; Sá, Vannessa Marinara de

; Rocha, Paulo Henrique Martins

; Oliveira, João Pedro Gomes de

; Amorim, Rafael Pereira de

; Silva, Elvis Vieira da

; Delboni, Vinícius Slonsky

; Barbosa, Maira Tonidandel

; Miranda, Luís Felipe José Ravic de

; Souza, Leonardo Cruz de

Arquivos de Neuro-Psiquiatria

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2024, Volume 82 Nº 5 elocation s00441787138

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Background Memory complaints are frequent in older adults and are associated with higher risk of cognitive decline. Objective To investigate the functional outcome of individuals with memory complaints followed up at primary care centers. Methods Data were collected between 2016 e 2020 in primary health care centers in Brazil. Patients underwent the Brief Cognitive Screening Battery, and the Functional Activities Questionnaire. Results The initial sample (2016) comprised 91 individuals classified into those with subjective cognitive decline (SCD, n = 15), mild cognitive impairment (MCI, n = 45), or dementia (n = 31). During follow-up, 8 individuals (8.8% of the initial sample) died and 26 (28.5% of the initial sample) were not found. Fifty-seven participants underwent clinical reassessment. Of 15 individuals with SCD, 7 were not found (46.7%), 4 (26.7%) progressed to MCI, and 4 (26.7%) remained stable. Of 45 individuals with MCI, 11 were not found (24.4%), 2 (4.4%) died, 6 (13.4%) progressed to dementia, 12 (26.7%) regressed to SCD, and 14 (31.1%) remained stable. Of 31 individuals with dementia, 8 were not found (25.8%), 6 (19.4%) died, 2 (6.5%) regressed to SCD, 7 (22.6%) regressed to MCI, and 8 remained stable (25.8%). Clinical improvement was due to the treatment of reversible causes, such as B12 hypovitaminosis and mood disorders. Older age, lower Mini-Mental State Examination, and higher scores of memory complaint, but not the use of benzodiazepines and of proton pump inhibitors, were predictors of functional status. Conclusion Despite their limits (short sample size, missing data), these results support the idea that adequate screening, follow-up, and treatment of reversible causes of dementia in primary care are essential. 201 202 Brazil Battery Questionnaire (2016 9 SCD (SCD 15, , 15) MCI (MCI 45, 45) 31. . 31) followup, followup follow up, follow-up 8.8% 88 (8.8 28.5% 285 28 5 (28.5 Fiftyseven Fifty seven reassessment 1 46.7%, 467 46.7% 46 (46.7%) 26.7% 267 (26.7% 24.4%, 244 24.4% 24 (24.4%) 4.4% 44 (4.4% 13.4% 134 13 (13.4% 31.1% 311 (31.1% 3 25.8%, 258 25.8% 25 (25.8%) 19.4% 194 19 (19.4% 6.5% 65 (6.5% 22.6% 226 22 (22.6% 25.8%. B B1 disorders age MiniMental Mini Mental Examination complaint inhibitors status short size data, data data) screening essential 20 (201 8.8 (8. 28.5 (28. 46.7 (46.7% 26.7 (26.7 24.4 (24.4% 4.4 (4.4 13.4 (13.4 31.1 (31.1 25.8 (25.8% 19.4 (19.4 6.5 (6.5 22.6 (22.6 (20 8. (8 28. (28 46. (46.7 26. (26. 24. (24.4 4. (4. 13. (13. (31. 25. (25.8 19. (19. 6. (6. 22. (22. (2 ( (46. (26 (24. (4 (13 (31 (25. (19 (6 (22 (46 (24 (1 (3 (25

Resumo Antecedentes Queixas de memória são frequentes em idosos e estão associadas ao maior risco de declínio cognitivo. Objetivo Investigar o desfecho funcional de indivíduos com queixas de memória acompanhados em centros atenção primária. Métodos Os dados foram coletados entre 2016 e 2020 em centros de atenção primária à saúde no Brasil. Os pacientes foram submetidos à Bateria Cognitiva Breve e ao Questionário de Atividades Funcionais. Resultados A amostra inicial (2016) foi composta por 91 indivíduos, classificados como tendo declínio cognitivo subjetivo (DCS, n = 15), comprometimento cognitivo leve (CCL, n = 45), ou demência (n = 31). Durante o seguimento, 8 indivíduos (8,8% da amostra inicial) faleceram e 26 (28,5% da amostra inicial) não foram encontrados. Cinquenta e sete participantes foram submetidos à reavaliação clínica. Dos 15 indivíduos com DCS, 7 não foram encontrados (46,7%), 4 (26,7%) declinaram para CCL e 4 (26,7%) permaneceram estáveis. Dos 45 indivíduos com CCL, 11 não foram encontrados (24,4%), 2 (4,4%) morreram, 6 (13,4%) declinaram para demência, 12 (26,7%) evoluíram para DCS e 14 (31,1%) permaneceram estáveis. Dos 31 indivíduos com demência, 8 não foram encontrados, (25,8%), 6 (19,4%) morreram, 2 (6,5%) evoluíram para DCS e 7 (22,6%) para CCL; e 8 permaneceram estáveis (25,8%). A melhora clínica deveu-se ao tratamento de causas reversíveis, como hipovitaminose B12 e transtornos de humor. A idade avançada, a baixa pontuação no Mini-Exame do Estado Mental e os escores de queixa de memória mais altos, mas não o uso de benzodiazepínicos e inibidores da bomba de prótons, foram preditores de declínio funcional. Conclusão Apesar de suas limitações (amostra pequena, dados ausentes), esses resultados corroboram que a triagem adequada, o acompanhamento e o tratamento de causas reversíveis de demência na atenção primária são essenciais. 201 202 Brasil Funcionais (2016 9 (DCS 15, , 15) (CCL 45, 45) 31. . 31) seguimento 8,8% 88 (8,8 28,5% 285 28 5 (28,5 1 46,7%, 467 46,7% 46 (46,7%) 26,7% 267 (26,7% 24,4%, 244 24,4% 24 (24,4%) 4,4% 44 (4,4% morreram 13,4% 134 13 (13,4% 31,1% 311 (31,1% 3 25,8%, 258 25,8% 25 (25,8%) 19,4% 194 19 (19,4% 6,5% 65 (6,5% 22,6% 226 22 (22,6% 25,8%. deveuse deveu se B B1 humor avançada MiniExame Mini Exame altos prótons pequena ausentes, ausentes ausentes) adequada essenciais 20 (201 8,8 (8, 28,5 (28, 46,7 (46,7% 26,7 (26,7 24,4 (24,4% 4,4 (4,4 13,4 (13,4 31,1 (31,1 25,8 (25,8% 19,4 (19,4 6,5 (6,5 22,6 (22,6 (20 8, (8 28, (28 46, (46,7 26, (26, 24, (24,4 4, (4, 13, (13, 31, (31, 25, (25,8 19, (19, 6, (6, 22, (22, (2 ( (46, (26 (24, (4 (13 (31 (25, (19 (6 (22 (46 (24 (1 (3 (25

https://doi.org/10.1055/s-0044-1787138

Biodegradable hybrid PLA composites incorporating coffee husks and mineral fillers
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Silva, Riquelme Gomes da

; Barboza, Laysa Silva

; Silveira, Pedro Henrique Poubel Mendonça da

; Conceição, Marceli do Nascimento da

; Ribeiro, Roberto Carlos da Conceição

; Bastos, Daniele Cruz

Polímeros

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2024, Volume 34 Nº 3 elocation e20240031

Resumo: En | Texto: En | PDF: En

Abstract This article details the development of hybrid composites with a PLA matrix filled with coffee husks, potassium feldspar, and Bahia Beige marble. Comprehensive analysis included FTIR, hardness, contact angle, density tests, SEM for microstructural insights, and XRF for optimizing raw material compositions. Also, variance analysis was applied in all results. The study revealed that these biodegradable composites hold promise for sustainable applications. Density variations were noted due to particle compaction, and hardness slightly decreased with coffee husks, attributed to uneven component distribution. Increased hydrophilicity was observed with filler addition. SEM confirmed strong interfacial adhesion, and color consistency was maintained. Notably, coffee husks significantly enhanced the degradation rate of PLA, achieving a 100% higher rate compared to pure PLA. The presence of calcium and potassium minerals offers additional benefits for soil health. The study suggests that thermoformed, multi-layered composite capsules can be fully biodegradable, promoting environmental sustainability in coffee capsule production. feldspar marble FTIR angle tests insights compositions Also results applications compaction distribution addition adhesion maintained Notably 100 health thermoformed multilayered multi layered production 10 1

https://doi.org/10.1590/0104-1428.20240020

Interpopulational genetic diversity in the medically important scorpion Tityus obscurus (Scorpiones: Buthidae) from northeastern Brazilian Amazonia Scorpiones (Scorpiones Buthidae
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PARDAL, Pedro Pereira de Oliveira

; COELHO, Johne Souza

; SILVA, Joaquim Martins da

; ALMEIDA, Bruno Rafael Ribeiro

; CHALKIDIS, Hipócrates Menezes

; BORGES, Adolfo

; ISHIKAWA, Edna Aoba Yassui

; DINIZ, Cristovam Guerreiro

; SANTOS-NETO, Guilherme da Cruz

; MELO, Mauro André Damasceno de

Acta Amazonica

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Set 2023, Volume 53 Nº 3 Páginas 215 - 222

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Scorpion envenoming is considered a public health problem in Brazil. A recent study described a variation in the clinical outcome of envenoming by Tityus obscurus in two populations separated by 850 km in the northeastern Amazon region. Our aim was to evaluate whether such clinical and toxinological variations are associated with underlying differences in genetic diversity between these two T. obscurus populations. We obtained DNA from five individuals of each population, in the municipalities of Belém and Santarém, located east and west of the state of Pará, Brazil, respectively. Gene regions encoding mitochondrial DNA (mtDNA) markers cytochrome oxidase subunit I (COI) and ribosomal 16S RNA (16S) were amplified and sequenced. Phylogenetic analyses were performed using maximum likelihood (ML) and Bayesian inferences (BA) for both molecular data (COI and 16S). The sampled T. obscurus populations corresponded to two distinct mtDNA lineages (genetic distance COI K2 P = 0.08 to 0.13; 16S K2 P = 0.10 to 0.11) with no shared mutations between groups and well supported by ML and BA inferences. Based on the divergence values found between eastern and western populations (COI, 0.07 to 0.12; 16S, 0.10), our study confirms the genetic heterogeneity of T. obscurus populations within the state of Pará, which correlates with observed venom and clinical differences, and reinforces the need for mapping the distribution of haplotypes throughout the geographic range of T. obscurus, to aid in future epidemiological, toxinological, and evolutionary studies. Brazil 85 region T population Santarém Pará respectively (mtDNA S (16S sequenced (ML (BA 16S. . 16S) K 008 0 08 0.0 0.13 013 13 010 10 0.1 0.11 011 11 COI, 007 07 0.12 012 12 0.10, , 0.10) epidemiological studies 8 00 0. 01 1

RESUMO O envenenamento por escorpiões é considerado um problema de saúde pública no Brasil. Um estudo recente descreve a variação do quadro clínico de envenenamento por Tityus obscurus em duas populações separadas por uma distância de 850 km no nordeste da Amazônia. O objetivo deste estudo foi avaliar se tais variações clínicas e toxicológicas estão associadas a diferenças subjacentes na diversidade genética entre essas duas populações de T. obscurus. Obtivemos DNA de cinco indivíduos de cada população nos municípios de Belém e Santarém, localizados a leste e oeste do estado do Pará, Brasil, respectivamente. Regiões gênicas que codificam marcadores de DNA mitocondrial (mtDNA) citocromo oxidase subunidade I (COI) e RNA ribossômico 16S (16S) foram amplificadas e sequenciadas. As análises filogenéticas foram realizadas por máxima verossimilhança (ML) e inferência Bayesiana (BA) para ambos os dados moleculares (COI e 16S). As populações de T. obscurus amostradas corresponderam a duas linhagens distintas de mtDNA (distância genética COI K2 P = 0,08 a 0,13; 16S K2 P = 0,10 a 0,11) sem mutações compartilhadas entre os grupos, e bem corroboradas por inferências ML e BA. Com base nos valores de divergência encontrados entre as populações oriental e ocidental (COI, 0,07 a 0,12; 16S, 0,10), nosso estudo confirma a heterogeneidade genética das populações de T. obscurus no estado do Pará. Os resultados são congruentes com as diferenças observadas no quadro clínico dos acidentes e toxicidade do veneno, e reforçam a necessidade de mapear a distribuição de haplótipos em toda a distribuição geográfica de T. obscurus, para auxiliar em futuros estudos epidemiológicos, toxinológicos e evolutivos. Brasil 85 Amazônia T Santarém Pará respectivamente (mtDNA S (16S sequenciadas (ML BA (BA 16S. . 16S) K 008 0 08 0,0 0,13 013 13 010 10 0,1 0,11 011 11 grupos COI, 007 07 0,12 012 12 0,10, , 0,10) veneno epidemiológicos evolutivos 8 00 0, 01 1

https://doi.org/10.1590/1809-4392202202441

BAROS PROTOCOL IN A UNIVERSITY HOSPITAL: WHAT IS THE IMPORTANCE IN THE POSTOPERATIVE RESULTS OF BARIATRIC SURGERY? HOSPITAL SURGERY
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Evangelista Neto, João

; Costa, José Henrique Cardoso Ferreira da

; Silva, Johnnes Henrique Vieira

; Carrijo Filho, Murilo Pimentel Leite

; Silva, Pedro Castor Batista Timóteo da

; Vasconcelos, Daniel Felipe Morais

; Albuquerque, e Pedro Cavalcanti de

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2023, Volume 36 elocation e1726

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT BACKGROUND: Although bariatric surgery is highly effective for the treatment of obesity and its comorbidities, preoperative weight loss has an impact on its results. AIMS: The aim of this study was to correlate preoperative weight loss with the outcome of bariatric surgery using the Bariatric Analysis and Reporting Outcome System scores. METHODS: This is a cross-sectional, observational study with 43 patients undergoing bariatric surgery that compared a group of 25 patients with a percentage of preoperative excess weight loss ³8% with a group of 18 patients with a percentage of preoperative excess weight loss <8% or with weight gain. The research took place at the bariatric surgery outpatient clinic of the Oswaldo Cruz University Hospital with patients 1 year after the surgery. RESULTS: Patients had a mean age of 40.8 years (42.7 percentage of preoperative excess weight loss ≥8% vs. 38.2 percentage of preoperative excess weight loss <8%, p=0.095). No significant difference was found between the two groups regarding preoperative comorbidities and body mass index at entry into the program. Higher preoperative body mass index (48.69 vs. 44.0; p=0.029) was observed in the group with percentage of preoperative excess weight loss <8%. No significant difference was found regarding the percentage of excess weight loss (71.4±15.4%; percentage of preoperative excess weight loss ≥8% vs. 69.47%±14.5 percentage of preoperative excess weight loss <8%; p=0.671), the result of the surgery according to the Bariatric Analysis and Reporting Outcome System scores protocol, the resolution of comorbidities, the quality of life, and the surgical complications between the two groups. CONCLUSIONS: Based on the available data, it is reasonable that bariatric surgery should not be denied to people who have not achieved pre-established weight loss before surgery. BACKGROUND results AIMS METHODS crosssectional, crosssectional cross sectional, sectional cross-sectional 4 2 ³8 8 <8 gain RESULTS 408 40 40. 42.7 427 42 7 (42. ≥8 vs 382 38 38. p=0.095. p0095 p p=0.095 . 0 095 p=0.095) program 48.69 4869 48 69 (48.6 44.0 440 44 p=0.029 p0029 029 71.4±15.4% 714154 71 15 (71.4±15.4% 6947145 47 14 5 69.47%±14. p=0.671, p0671 p=0.671 , 671 p=0.671) protocol life CONCLUSIONS data preestablished pre established ³ < 42. (42 ≥ 3 p009 p=0.09 09 48.6 486 6 (48. 44. p=0.02 p002 02 71.4±15.4 71415 (71.4±15.4 694714 69.47%±14 p067 p=0.67 67 (4 p00 p=0.0 48. (48 71.4±15. 7141 (71.4±15. 69471 69.47%±1 p06 p=0.6 ( p0 p=0. 71.4±15 714 (71.4±15 6947 69.47%± p=0 71.4±1 (71.4±1 694 69.47% p= 71.4± (71.4± 69.47 71.4 (71.4 69.4 71. (71. 69. (71 (7

RESUMO RACIONAL: Apesar da cirurgia bariátrica ser altamente eficaz para o tratamento da obesidade e suas comorbidades, ainda não está bem estabelecido o impacto da perda de peso pré-operatória em seus resultados. OBJETIVOS: Correlacionar a perda de peso pré-operatória com o resultado da cirurgia bariátrica pelos escores do método Bariatric Analysis and Reportig Outcome System. MÉTODOS: Estudo observacional transversal com 43 pacientes submetidos a cirurgia bariátrica que comparou um grupo de 25 pacientes com percentual de perda do excesso de peso pré-operatória igual ou maior a 8% com um grupo de 18 pacientes com percentual de perda do excesso de peso pré-operatória menor a 8% ou com ganho de peso. A pesquisa ocorreu no ambulatório de Cirurgia Bariátrica do Hospital Universitário Oswaldo Cruz com pacientes após um ano da cirurgia. RESULTADOS: Os pacientes tinham uma média de idade de 40,8 anos (42,7 percentual de perda do excesso de peso pré-operatória ≥8% vs 38,2 percentual de perda do excesso de peso pré-operatória <8%, p=0.095). Não foram encontradas diferenças significativas entre os dois grupos em relação às comorbidades pré-operatórias e o IMC na entrada do programa. Foi observado maior IMC pré-operatório (48,69 vs 44,0; p=0,029) no grupo com percentual de perda do excesso de peso pré-operatória <8%. Não foram encontradas diferenças significativas em relação ao percentual de perda do excesso de peso (71,4±15,4%; percentual de perda do excesso de peso pré-operatória ≥8% vs 69,47±14,5% percentual de perda do excesso de peso pré-operatória <8%, p=0,671), ao resultado da cirurgia pelo protocolo Bariatric Analysis and Reportig Outcome System, a resolução das comorbidades, a qualidade de vida e as complicações cirúrgicas entre os dois grupos. CONCLUSÕES: Com base nos dados disponíveis é condizente que a cirurgia bariátrica não seja negada a pessoas que não atingiram uma perda de peso pré-estabelecida antes da cirurgia. RACIONAL préoperatória pré operatória resultados OBJETIVOS System MÉTODOS 4 2 8 1 RESULTADOS 408 40 40, 42,7 427 42 7 (42, ≥8 382 38 38, <8% p=0.095. p0095 p p=0.095 . 0 095 p=0.095) préoperatórias operatórias programa préoperatório operatório 48,69 4869 48 69 (48,6 44,0 440 44 p=0,029 p0029 029 71,4±15,4% 714154 71 15 (71,4±15,4% 6947145 47 14 5 69,47±14,5 p=0,671, p0671 p=0,671 , 671 p=0,671) CONCLUSÕES préestabelecida estabelecida 42, (42 ≥ 3 <8 p009 p=0.09 09 48,6 486 6 (48, 44, p=0,02 p002 02 71,4±15,4 71415 (71,4±15,4 694714 69,47±14, p067 p=0,67 67 (4 < p00 p=0.0 48, (48 p=0,0 71,4±15, 7141 (71,4±15, 69471 69,47±14 p06 p=0,6 ( p0 p=0. p=0, 71,4±15 714 (71,4±15 6947 69,47±1 p=0 71,4±1 (71,4±1 694 69,47± p= 71,4± (71,4± 69,47 71,4 (71,4 69,4 71, (71, 69, (71 (7

https://doi.org/10.1590/0102-672020230002e1726

Fecal microbiota transplantation and its repercussions in patients with melanoma refractory to anti-PD-1 therapy: scope review antiPD1 antiPD anti PD 1 anti-PD- therapy anti-PD
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BARBOSA, EDUARDO CERCHI

; BUCAR, EDUARDA EMÍLIA CRUZ

; JUBÉ, GABRIEL RODRIGUES

; SILVEIRA, LETÍCIA BONFIM

; SILVA, NATÁLIA CÂNDIDO DUAILIBE

; FARIA, PEDRO CARVALHO CAMPOS

; RAMOS, PEDRO LUCAS CARNEIRO

; MORAES, VITOR RYUITI YAMAMOTO

; BARROS, JOÃO ORMINDO BELTRÃO

Revista do Colégio Brasileiro de Cirurgiões

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2023, Volume 50 elocation e20233490

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Introduction: despite being extremely effective in some cases, up to 70% of patients with melanoma do not respond to anti-PD-1/PD-L1 (primary resistance) and many of the responders eventually progress (secondary resistance). Extensive efforts are being made to overcome this resistance through new strategies, especially aimed at modulating the intestinal microbiota. Objective: to assess whether fecal microbiota transplantation (FMT), associated with immunotherapy, is beneficial in the clinical course of patients with refractory melanoma. Methods: this is a scope review, based on studies collected on the MEDLINE, ScienceDirect, The Cochrane Library, Embase and BMJ Journals; using the terms: “Antibodies, Monoclonal”; “Drug Resistance, Neoplasm”; “Fecal Microbiota Transplantation”; “Host Microbial Interactions”; “Immunotherapy”; “Melanoma”; and “Microbiota”. Clinical trials, in English, with relevant data on the subject and fully available were included. A cut-off period was not determined, due to the limited amount of evidence on the topic. Results: crossing the descriptors allowed the identification of 342 publications and, after applying the eligibility criteria, allowed the selection of 4 studies. From the analyses, it was observed that a considerable part of those studied overcame resistance to immune checkpoint inhibitors after FMT, with better response to treatment, less tumor growth and increased beneficial immune response. Conclusion: it is noted that FMT favors the response of melanoma to immunotherapy, translated into significant clinical benefit. However, further studies are necessary for the complete elucidation of the bacteria and the mechanisms involved, as well as for the translation of new evidence to oncological care practice. Introduction cases 70 antiPD1/PDL1 antiPD1PDL1 antiPDPDL anti PD 1/PD L1 1 L anti-PD-1/PD-L primary secondary resistance. . strategies Objective , (FMT) immunotherapy Methods review MEDLINE ScienceDirect Library Journals terms Antibodies, Antibodies “Antibodies Monoclonal Monoclonal” Drug Resistance Neoplasm Neoplasm” Fecal Transplantation Transplantation” Host Interactions Interactions” Immunotherapy “Immunotherapy” Melanoma “Melanoma” Microbiota. “Microbiota” trials English included cutoff cut off determined topic Results 34 criteria analyses treatment Conclusion benefit However involved practice 7 antiPD1 PDL1 antiPD PDL antiPD1/PDL antiPD1PDL 1PD (FMT “Immunotherapy “Melanoma “Microbiota 3

RESUMO Introdução: apesar de extremamente eficaz em alguns casos, até 70% dos pacientes com melanoma não respondem aos anti-PD-1/PD-L1 (resistência primária) e muitos dos respondedores, eventualmente, acabam progredindo (resistência secundária). Extensos esforços estão sendo realizados para superar esta resistência através de novas estratégias, sobretudo, visando a modulação da microbiota intestinal. Objetivo: avaliar se o transplante de microbiota fecal (TMF), associado à imunoterapia, é benéfico no curso clínico do paciente com melanoma refratário. Métodos: trata-se de uma revisão de escopo, baseada em estudos coletados nas plataformas MEDLINE, ScienceDirect, The Cochrane Library, Embase e BMJ Journals; utilizando os descritores: “Antibodies, Monoclonal”; “Drug Resistance, Neoplasm”; “Fecal Microbiota Transplantation”; “Host Microbial Interactions”; “Immunotherapy”; “Melanoma”; e “Microbiota”. Foram incluídos ensaios clínicos, na língua inglesa, com dados relevantes sobre a temática e disponíveis integralmente. Não foi determinado um período de corte temporal, devido à quantidade limitada de evidências sobre o tema. Resultados: o cruzamento dos descritores permitiu a identificação de 342 publicações e, após a aplicação dos critérios de elegibilidade, permitiu a seleção de 4 estudos. A partir das análises, observou-se que grande parte dos estudados superaram a resistência aos inibidores do checkpoint imunológico pós-TMF, com melhor resposta ao tratamento, menor crescimento tumoral e aumento da resposta imunológica benéfica. Conclusão: nota-se que o TMF favorece a resposta do melanoma à imunoterapia, traduzido por benefício clínico significativo. Entretanto, novos estudos são necessários para a completa elucidação das bactérias e mecanismos envolvidos, bem como para que haja a translação das novas evidências para a prática assistencial oncológica. Introdução casos 70 antiPD1/PDL1 antiPD1PDL1 antiPDPDL anti PD 1/PD L1 1 L anti-PD-1/PD-L primária respondedores eventualmente secundária. secundária . secundária) estratégias sobretudo intestinal Objetivo TMF, , (TMF) imunoterapia refratário Métodos tratase trata escopo MEDLINE ScienceDirect Library Journals Antibodies, Antibodies “Antibodies Monoclonal Monoclonal” Drug Resistance Neoplasm Neoplasm” Fecal Transplantation Transplantation” Host Interactions Interactions” Immunotherapy “Immunotherapy” Melanoma “Melanoma” Microbiota. “Microbiota” clínicos inglesa integralmente temporal tema Resultados 34 elegibilidade análises observouse observou pósTMF, pósTMF pós pós-TMF tratamento benéfica Conclusão notase nota significativo Entretanto envolvidos oncológica 7 antiPD1 PDL1 antiPD PDL antiPD1/PDL antiPD1PDL 1PD (TMF “Immunotherapy “Melanoma “Microbiota 3

https://doi.org/10.1590/0100-6991e-20233490-en

10.

Vitellogenin genes are transcribed in Culex quinquefasciatus ovary
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Moura, Alexandre S

; Costa-da-Silva, André Luis

; Peixoto, Pedro S

; Maciel, Ceres

; Cardoso, André F

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e220143

Resumo: En | Texto: En | PDF: En

BACKGROUND Culex quinquefasciatus, a cosmopolitan, domestic, and highly anthropophilic mosquito, is a vector of pathogenic arboviruses such as West Nile virus and Rift Valley virus, as well as lymphatic filariasis. The current knowledge on its reproductive physiology regarding vitellogenin expression in different tissues is still limited. OBJECTIVES In this study, we analysed the transcriptional profiles of vitellogenin genes in the fat body and ovaries of C. quinquefasciatus females during the first gonotrophic cycle. METHODS C. quinquefasciatus ovaries and/or fat bodies were dissected in different times during the first gonotrophic cycle and total RNA was extracted and used for reverse transcription polymerase chain reaction, quantitative real time-PCR, and in situ hybridisation. FINDINGS We confirmed the classical descriptions of the vitellogenic process in mosquitoes by verifying that vitellogenin genes are transcribed in the fat bodies of C. quinquefasciatus females. Using RNA in situ hybridisation approach, we showed that vitellogenin genes are also transcribed in developing ovaries, specifically by the follicle cells. MAIN CONCLUSIONS This is the first time that vitellogenin transcripts are observed in mosquito ovaries. Studies to determine if Vg transcripts are translated into proteins and their contribution to the reproductive success of the mosquito need to be further investigated. cosmopolitan domestic filariasis limited study C andor or reaction timePCR, timePCR PCR, PCR time-PCR approach cells investigated

https://doi.org/10.1590/0074-02760220143

11.

First report of putative Leishmania RNA virus 2 (LRV2) in Leishmania infantum strains from canine and human visceral leishmaniasis cases in the southeast of Brazil LRV2 LRV (LRV2 (LRV
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Rêgo, Felipe Dutra

; da Silva, Eduardo Sérgio

; Lopes, Valeriana Valadares

; Teixeira-Neto, Rafael Gonçalves

; Belo, Vinícius Silva

; Fonseca Júnior, Antônio Augusto

; Pereira, Diego Andrade

; Pena, Heber Paulino

; Laurenti, Márcia Dalastra

; Araújo, Gabriela V

; da Matta, Vânia Lúcia Ribeiro

; Chouman, Islam Hussein

; Burrin, Thainá Bergantin

; Sandoval, Carmen M

; Barrouin-Melo, Stella Maria

; de Pinho, Flaviane Alves

; de Andrade, Hélida Monteiro

; Nunes, Ramon Vieira

; Gontijo, Célia Maria Ferreira

; Soccol, Vanete Thomaz

; Klocek, Donnamae

; Grybchuk, Danyil

; Macedo, Diego Henrique

; do Monte-Neto, Rubens Lima

; Yurchenko, Vyacheslav

; Soares, Rodrigo Pedro

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e230071

Resumo: En | Texto: En | PDF: En

BACKGROUND Leishmania RNA virus 1 (LRV1) is commonly found in South American Leishmania parasites belonging to the subgenus Viannia, whereas Leishmania RNA virus 2 (LRV2) was previously thought to be restricted to the Old-World pathogens of the subgenus Leishmania. OBJECTIVES In this study, we investigated the presence of LRV2 in strains of Leishmania (L.) infantum, the causative agent of visceral leishmaniasis (VL), originating from different hosts, clinical forms, and geographical regions. METHODS A total of seventy-one isolates were screened for LRV2 using semi-nested reverse transcription-polymerase chain reaction (RT-PCR) targeting the RNA-dependent RNA polymerase (RdRp) gene. FINDINGS We detected LRV2 in two L. infantum isolates (CUR268 and HP-EMO) from canine and human cases, respectively. MAIN CONCLUSIONS To the best of our knowledge, this is the first detection of LRV2 in the New World. LRV1 LRV (LRV1 Viannia (LRV2 OldWorld Old World study L (L. VL, VL , (VL) hosts forms regions seventyone seventy one seminested semi nested transcriptionpolymerase transcription RTPCR RT PCR (RT-PCR RNAdependent dependent RdRp (RdRp gene CUR268 CUR (CUR26 HPEMO HP EMO HP-EMO cases respectively knowledge (LRV (L (VL CUR26 (CUR2 CUR2 (CUR

https://doi.org/10.1590/0074-02760230071

12.

Hospital mortality from covid-19 in children and adolescents in Brazil in 2020–2021 covid19 covid 19 covid-1 20202021 2020 2021 2020–202 covid1 1 covid- 2020202 202 2020–20 202020 20 2020–2 20202 2 2020–
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Silva, Amanda Cilene Cruz Aguiar Castilho da

; Luiz, Ronir Raggio

; Moraes, José Rodrigo de

; Rocha, Pedro Henrique Vieira

; Zeitoune, Regina Célia Gollner

; Barbosa, Arnaldo Prata

; Moreira, Jessica Pronestino de Lima

Revista de Saúde Pública

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2023, Volume 57 elocation 56

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT OBJECTIVE To describe cases, deaths, and hospital mortality from covid-19 in children and adolescents in Brazil, according to age group, during the evolving phases of the pandemic in 2020 and 2021. METHODS Census of patients aged up to 19 committed with severe acute respiratory syndrome, due to covid-19 or unspecified, notified to the Brazilian Influenza Epidemiological Surveillance Information System, from January 1, 2020, to December 31, 2021. The two years were divided into six phases, covering the spread of the disease—first, second and third wave—as well as the impact of vaccination. The pediatric population was categorized into infants, preschoolers, schoolchildren, and adolescents. Hospital mortality was assessed by pandemic phase and age group. RESULTS A total of 144,041 patients were recorded in the two years, 18.2% of whom had confirmed cases of covid-19. Children under 5 years old (infants and preschoolers) accounted for 62.8% of those hospitalized. A total of 4,471 patients died, representing about 6.1 deaths per day. Infants were the ones who most progressed to the intensive care unit (24.7%) and had the highest gross number of deaths (n = 2,012), but mortality was higher among adolescents (5.7%), reaching 9.8% in phase 1. The first peak of deaths occurred in phase 1 (May/2020), and two other peaks occurred in phase 4 (March/2021 and May/2021). There was an increase in cases and deaths for younger ages since phase 4. Hospital mortality in the pediatric population was higher in phases 1, 4, and 6, following the phenomena of dissemination/interiorization of the virus in the country, beginning of the second wave and beginning of the third wave, respectively. CONCLUSION The absolute number of cases of covid-19 in children and adolescents is significant. Although complete vaccination in descending order of age provided a natural deviation in age range, there was a greater gap between the curve of new hospitalized cases and the curve of deaths, indicating the positive impact of immunization. covid19 covid covid-1 Brazil group 202 2021 syndrome unspecified System 31 diseasefirst, diseasefirst disease first, disease—first waveas infants preschoolers schoolchildren 144041 144 041 144,04 182 18 2 18.2 covid19. 19. 628 62 8 62.8 4471 471 4,47 died 61 6 6. day 24.7% 247 24 7 (24.7% n 2,012, 2012 2,012 , 012 2,012) 5.7%, 57 5.7% (5.7%) 98 9 9.8 May/2020, May2020 May May/2020 (May/2020) March/2021 March2021 March (March/202 May/2021. May2021 May/2021 . May/2021) disseminationinteriorization dissemination interiorization country respectively significant range immunization covid1 covid- 20 3 14404 14 04 144,0 18. 62. 447 47 4,4 24.7 (24.7 201 2,01 01 5.7 (5.7% 9. May202 May/202 (May/2020 March/202 March202 (March/20 1440 0 144, 44 24. (24. 2,0 5. (5.7 May20 May/20 (May/202 March/20 March20 (March/2 (24 2, (5. May2 May/2 (May/20 March/2 March2 (March/ (2 (5 May/ (May/2 March/ (March ( (May/ (May

RESUMO OBJETIVO Descrever casos, óbitos e mortalidade hospitalar por covid-19 em crianças e adolescentes no Brasil, conforme faixa etária, durante as fases de evolução da pandemia em 2020 e 2021. MÉTODOS Censo de pacientes de até 19 anos internados com síndrome respiratória aguda grave, por covid-19 ou não especificada, notificados ao Sistema de Informação de Vigilância Epidemiológica da Gripe do Brasil, entre 1 de janeiro de 2020 e 31 de dezembro de 2021. Os dois anos foram divididos em seis fases, abrangendo a disseminação da doença − primeira, segunda e terceira onda −, bem como o impacto da vacinação. A população pediátrica foi categorizada em lactentes, pré-escolares, escolares e adolescentes. A mortalidade hospitalar foi avaliada por fase da pandemia e faixa etária. RESULTADOS Foram contabilizados 144.041 pacientes nos dois anos, sendo 18,2% casos de covid-19 confirmados. Menores de 5 anos (lactentes e pré-escolares) corresponderam a 62,8% dos hospitalizados. Evoluíram a óbito 4.471, representando cerca 6,1 óbitos por dia. Os lactentes foram os que mais evoluíram para unidade de terapia intensiva (24,7%) e apresentaram o maior número bruto de óbito (n = 2.012), porém a mortalidade foi maior entre os adolescentes (5,7%), chegando a 9,8% na fase 1. O primeiro pico de óbitos ocorreu na fase 1 (maio/2020), e outros dois picos ocorreram na fase 4 (março/2021 e maio/2021). Verificou-se avanço de casos e óbitos para as idades inferiores desde a fase 4. A mortalidade hospitalar na população pediátrica foi maior nas fases 1, 4 e 6, acompanhando os fenômenos de disseminação/interiorização do vírus no país, início da segunda onda e início da terceira onda, respectivamente. CONCLUSÃO O número absoluto de casos de covid-19 em crianças e adolescentes é expressivo. Embora a vacinação completa em ordem decrescente de idade tenha proporcionado um desvio natural de faixa etária, ocorreu um distanciamento maior entre a curva de novos casos hospitalizados e a curva de óbitos, indicando o impacto positivo da imunização. covid19 covid covid-1 Brasil etária 202 2021 grave especificada 3 primeira préescolares, préescolares pré escolares, pré-escolares 144041 144 041 144.04 182 18 2 18,2 confirmados 628 62 8 62,8 4471 471 4.471 61 6 dia 24,7% 247 24 7 (24,7% n 2.012, 2012 2.012 , 012 2.012) 5,7%, 57 5,7% (5,7%) 98 9 9,8 maio/2020, maio2020 maio maio/2020 (maio/2020) março/2021 março2021 março (março/202 maio/2021. maio2021 maio/2021 . maio/2021) Verificouse Verificou se disseminaçãointeriorização interiorização país respectivamente expressivo imunização covid1 covid- 20 14404 14 04 144.0 18, 62, 447 47 4.47 24,7 (24,7 201 2.01 01 5,7 (5,7% 9, maio202 maio/202 (maio/2020 março/202 março202 (março/20 1440 0 144. 44 4.4 24, (24, 2.0 5, (5,7 maio20 maio/20 (maio/202 março/20 março20 (março/2 (24 2. (5, maio2 maio/2 (maio/20 março/2 março2 (março/ (2 (5 maio/ (maio/2 março/ (março ( (maio/ (maio

https://doi.org/10.11606/s1518-8787.2023057005172

13.

Guidelines for Trypanosoma cruzi-HIV Co-infection and other Immunosuppressive Conditions: Diagnosis, Treatment, Monitoring, and Implementation from the International Network of Care and Studies - 2023 cruziHIV cruzi HIV Coinfection Co infection Conditions Diagnosis Treatment Monitoring 202 20 2
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Almeida, Eros Antonio de

; Mendes, Fernanda de Souza Nogueira Sardinha

; Ramos Júnior, Alberto Novaes

; Sousa, Andréa Silvestre de

; Pavan, Tycha Bianca Sabaini

; Mediano, Mauro Felippe Felix

; Ostermayer, Alejandro Luquetti

; Hasslocher-Moreno, Alejandro Marcel

; Britto, Constança Felicia De Paoli de Carvalho

; Novaes, Christina Gallafrio

; Correia, Dalmo

; Santos, Fred Luciano Neves

; Silva, Gilberto Marcelo Sperandio da

; Fernandez, Marisa Liliana

; Lima, Mayara Maia

; Carvalho, Noêmia Barbosa de

; Moreira, Otacílio da Cruz

; Albajar-Viñas, Pedro

; Leite, Ruth Moreira

; Palmeira, Swamy Lima

; Costa, Veruska Maia da

; Yasuda, Maria Aparecida Shikanai

Revista da Sociedade Brasileira de Medicina Tropical

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2023, Volume 56 elocation e0549-2023

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.1590/0037-8682-0549-2023

14.

ACUTE ABDOMEN IN INTENSIVE CARE UNIT: ETIOLOGY, COMORBIDITY AND SEVERITY OF 1,523 PATIENTS UNIT ETIOLOGY 1523 1 523 1,52 152 52 1,5 15 5 1,
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ALMEIDA FILHO, Geraldo Fernandes de

; SILVA, Pedro Paulo Costa e

; VALVERDE FILHO, Murilo Tavares

; MORAIS, Maria Clara Alves

; CHAGAS, Paulo Bravo de Oliveira

; D’OLIVEIRA, Ricardo Azevedo Cruz

; CODES, Liana

; BITTENCOURT, Paulo Lisboa

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2023, Volume 36 elocation e1778

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT BACKGROUND: Clinical features and outcomes of patients admitted to the intensive care unit due to acute abdomen are important to be investigated. AIMS: To evaluate the outcomes of critically ill subjects with acute abdomen according to etiology, comorbidity and severity. METHODS: Outcomes of 1,523 patients (878 women, mean age 66±18 years) consecutively admitted to a specialized gastrointestinal intensive care unit with different causes of acute abdomen from January 2012 to December 2019, were retrospectively evaluated according to etiology, comorbidity and severity. RESULTS: The most common causes of acute abdomen were obstructive and inflammatory, particularly large bowel obstruction (27%), small bowel obstruction (18%) and acute pancreatitis (17%). Overall mortality was 13%. Surgery was required in 34% of patients. Median length of stay in the hospital was 9 [1-101] days. On univariate analysis mortality was significantly associated with age, APACHE II, Charlson comorbidity index, requirement for surgery and malignancy (p<0.0001), but only APACHE II, Charlson comorbidity index and surgical interventional remained significant on multivariate analysis. CONCLUSIONS: Critically ill patients admitted to the intensive care unit with acute abdomen constitute a heterogeneous group of subjects with different prognosis. Mortality is more related to the severity of the disease, comorbidity and need for surgery than to the etiology of the acute abdomen. BACKGROUND investigated AIMS METHODS 1523 1 523 1,52 878 (87 women 6618 66 18 66±1 years 201 2019 RESULTS inflammatory 27%, 27 27% , (27%) 18% (18% 17%. 17 17% . (17%) 13 13% 34 1101 101 [1-101 days II p<0.0001, p00001 p p<0.0001 0 0001 (p<0.0001) CONCLUSIONS prognosis disease 152 52 1,5 87 (8 661 6 66± 20 2 (27% (18 (17% 3 110 10 [1-10 p0000 p<0.000 000 (p<0.0001 15 5 1, 8 ( (27 (1 (17 11 [1-1 p000 p<0.00 00 (p<0.000 (2 [1- p00 p<0.0 (p<0.00 [1 p0 p<0. (p<0.0 [ p<0 (p<0. p< (p<0 (p< (p

RESUMO RACIONAL: As características clínicas e os desfechos dos pacientes internados na unidade de terapia intensiva devido ao abdômen agudo são importantes serem investigados. OBJETIVOS: Avaliar os desfechos de indivíduos gravemente doentes com abdômen agudo de acordo com etiologia, gravidade e comorbidade. MÉTODOS: Os desfechos de 1.523 pacientes (878 mulheres, média de idade 66±18 anos) que foram previamente admitidos em uma unidade de terapia intensiva especializada em doenças gastrointestinais, com diferentes causas de abdômen agudo entre janeiro de 2012 e dezembro de 2019, foram avaliados retrospectivamente segundo etiologia, comorbidade e gravidade. RESULTADOS: As causas mais comuns de abdômen agudo foram obstrutivas e inflamatórias, com destaque para obstrução em colon (27%), em intestino delgado (18%) e pancreatite aguda (17%). A mortalidade geral foi de 13%. A cirurgia foi necessária em 34%. A média de permanência no hospital foi de 9 [1-101] dias. Na análise univariada a mortalidade foi significativamente associada à idade, APACHE II, índice de comorbidade de Charlson, necessidade de abordagem cirúrgica e presença de malignidade (p<0,0001), mas apenas APACHE II, índice de comorbidade de Charlson e intervenção cirúrgica permaneceram significativos na análise multivariada. CONCLUSÕES: Pacientes internados na unidade de terapia intensiva com abdômen agudo constituem um grupo heterogêneo de indivíduos com prognóstico diferente. A mortalidade está mais relacionada com a gravidade da doença, comorbidade e necessidade de cirurgia do que com a etiologia do abdome agudo. RACIONAL investigados OBJETIVOS MÉTODOS 1523 1 523 1.52 878 (87 mulheres 6618 66 18 66±1 anos gastrointestinais 201 2019 RESULTADOS inflamatórias 27%, 27 27% , (27%) 18% (18% 17%. 17 17% . (17%) 13 13% 34 34% 1101 101 [1-101 dias II p<0,0001, p00001 p p<0,0001 0 0001 (p<0,0001) multivariada CONCLUSÕES diferente doença 152 52 1.5 87 (8 661 6 66± 20 2 (27% (18 (17% 3 110 10 [1-10 p0000 p<0,000 000 (p<0,0001 15 5 1. 8 ( (27 (1 (17 11 [1-1 p000 p<0,00 00 (p<0,000 (2 [1- p00 p<0,0 (p<0,00 [1 p0 p<0, (p<0,0 [ p<0 (p<0, p< (p<0 (p< (p

https://doi.org/10.1590/0102-672020230060e1778

15.

Contribution of public oral pathology services to the diagnosis of oral and oropharyngeal cancer in Brazil
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LOUREDO, Brendo Vinicius Rodrigues

; CURADO, Maria Paula

; PENAFORT, Paulo Victor Mendes

; DE ARRUDA, José Alcides Almeida

; ABREU, Lucas Guimarães

; MESQUITA, Ricardo Alves

; PINTO-JÚNIOR, Décio dos Santos

; ABRAHÃO, Aline Corrêa

; ANDRADE, Bruno Augusto Benevenuto de

; AGOSTINI, Michelle

; MORAES, Renata Mendonça

; ANBINDER, Ana Lia

; DOURADO, Pedro Henrique Silva

; SANTOS, Teresa Cristina Ribeiro Bartholomeu dos

; PIRES, Fábio Ramoa

; BORDIGNON, Natalia Cristina Trentin

; GONDAK, Rogério Oliveira

; DE OLIVEIRA, Marcia Gaiger

; CARRARD, Vinicius Coelho

; MARTINS, Manoela Domingues

; SOUSA-NETO, Sebastião Silvério

; ARANTES, Diego Antônio Costa

; MENDONÇA, Elismauro Francisco

; CIESLAK-SANCHES, Silvia Roberta

; ANTUNES, Daniella Moraes

; AMARAL-SILVA, Gleyson Kleber do

; MANIERI, Patricia Rubia

; RAMALHO, Luciana Maria Pedreira

; DOS SANTOS, Jean Nunes

; LEONEL, Augusto César Leal da Silva

; PEREZ, Danyel Elias da Cruz

; VERHEUL, Hannah Carmem Carlos Ribeiro Silva

; BARROSO, Keila Martha Amorim

; RODRIGUES, Flávia Luiza Santos

; GONZAGA, Amanda Katarinny Goes

; FERNANDES, Romana Renery

; DE SOUZA, Lélia Batista

; SOUZA, Lucas Lacerda de

; PONTES, Flávia Sirotheau Corrêa

; PONTES, Hélder Antônio Rebelo

; SILVA, Caroline Alfaia

; CÂMARA, Jeconias

; LIBÓRIO-KIMURA, Tatiana Nayara

; SANTOS-SILVA, Alan Roger

; LOPES, Márcio Ajudarte

; ALMEIDA, Oslei Paes de

; ROMAÑACH, Mário José

; VARGAS, Pablo Agustin

Brazilian Oral Research

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- SciELO Analytics

2023, Volume 37 elocation e126

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System. (OMPLs SCC. . (SCC) crosssectional cross sectional North, North (North Northeast CentralWest, CentralWest Central West, West Central-West South. South South) 201 120010 120 010 120,01 20102019, 20102019 , (2010-2019) 69 6 9 6.9 8,321 8321 8 321 (8,32 0.8%, 08 0 (0.8% 95 cases, 4.9%, 49 4 (4.9% 5971 5 971 5,97 1.2%, 12 1 2 (1.2% 1399 399 1,39 Brazils s 64.5%, 645 64.5% 64 (64.5%) located men years level consumption group nonCaucasian non formercurrent former users Institute 99 9.9 Therefore System (SCC 20 12001 01 120,0 2010201 (2010-2019 6. 8,32 832 32 (8,3 0.8% (0.8 4.9% (4.9 597 97 5,9 1.2% (1.2 139 39 1,3 64.5 (64.5% 9. 1200 120, 201020 (2010-201 8,3 83 3 (8, 0.8 (0. 4.9 (4. 59 5, 1.2 (1. 13 1, 64. (64.5 20102 (2010-20 8, (8 0. (0 4. (4 1. (1 (64. (2010-2 ( (64 (2010- (6 (2010 (201 (20 (2

https://doi.org/10.1590/1807-3107bor-2023.vol37.0126

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