Pesquisa | SciELO

ABSTRACT BACKGROUND: The human telomerase reverse transcriptase (hTERT) enzyme, encoded by the hTERT gene, synthesizes protective telomeric sequences on chromosomes and plays a fundamental role in cancer formation. Methylation of the hTERT gene has an upregulatory effect, increasing hTERT enzyme synthesis and allowing continuous tumor cell division. OBJECTIVE: In a group of patients with breast cancer, we aimed to analyze the methylation status of hTERT in the tumor, surrounding tissue, and circulating free deoxyribonucleic acid (cfDNA) of blood collected on the day of mastectomy and then approximately one year later. DESIGN AND SETTING: A prospective study was conducted at a university hospital in Rio de Janeiro, Brazil. METHODS: Samples were collected from 15 women with breast cancer on the day of mastectomy and approximately one year postoperatively. cfDNA was analyzed by sodium bisulfite conversion, followed by polymerase chain reaction, electrophoresis, and silver nitrate staining. RESULTS: Methylation of hTERT was detected in the tumors and surrounding tissues of all 15 patients. Five patients displayed hTERT methylation in the cfDNA from the blood of the first collection. Of the ten patients who returned for the second collection, three showed methylation. Two patients with methylation in the first collection did not display methylation in the second collection. One patient with no methylation in the first collection displayed methylation in the second collection, and one patient had a diminished level of methylation in the second collection. CONCLUSION: Only one-third of patients displayed methylation in their cfDNA, which may be related to the success of chemotherapy. BACKGROUND (hTERT formation effect division OBJECTIVE tissue (cfDNA later SETTING Janeiro Brazil METHODS 1 postoperatively conversion reaction electrophoresis staining RESULTS CONCLUSION onethird third chemotherapy

https://doi.org/10.1590/1516-3180.2023.0140.r1.04032024

Effect of thyme essential oil on the properties of poly (butylene adipate-co-terephthalate)(PBAT) butylene adipatecoterephthalatePBAT adipate co terephthalate PBAT adipate-co-terephthalate)(PBAT
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Luna, Pâmela Barcelar Ferreira Gomes da Silva de

; Caetano, Viviane Fonseca

; Andrade, Michelle Félix de

; Silva, Ivo Diego de Lima

; Araújo, Tiago Lopes de

; Souza, Karina Carvalho de

; Almeida, Yêda Medeiros Bastos de

; Vinhas, Glória Maria

Polímeros

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2024, Volume 34 Nº 1 elocation e20240005

Resumo: En | Texto: En | PDF: En

Abstract In this study, thyme essential oil was added to poly (butylene adipate-co-terephthalate) (PBAT) films in a variety of compositions (0, 1, 2, 5, 10, 15, and 20% w/w), and the effect of the essential oil on the PBAT's characteristics was evaluated. The films were produced using the casting technique. Thyme essential oil (EO) was evaluated by mid-infrared, gas chromatography-mass spectrometer, and antimicrobial activity. The films were evaluated by mid-infrared, mechanical, and thermal tests. The results demonstrated that EO has a higher concentration of o-cymene and antimicrobial activity against the bacteria Escherichia coli and Staphylococcus aureus. The films were analyzed for their mechanical and thermal properties according to the compositions tested. The films have shown promise for use as active packaging. study butylene adipatecoterephthalate adipate co terephthalate adipate-co-terephthalate PBAT (PBAT 0, 0 (0 1 2 5 10 15 20 w/w, ww w/w , w w/w) PBATs s technique (EO midinfrared, midinfrared mid infrared, infrared mid-infrared chromatographymass chromatography mass spectrometer tests ocymene o cymene aureus tested packaging (

https://doi.org/10.1590/0104-1428.20230009

Molecular monitoring by CDKN2A/p16INK4A and RB1 gene methylation in breast cancer CDKN2Ap16INK4A CDKNApINKA CDKN2A p16INK4A CDKN A p INK RB Ap CDKNA pINKA
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Queiroz, Luiz Fernando de

; Silva, Marcelo Soares da Mota e

; Rosman, Fernando Colonna

; Rosas, Siane Lopes Bittencourt

; Souza, Heitor Siffert Pereira de

; Carvalho, Maria da Glória da Costa

Revista da Associação Médica Brasileira

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2024, Volume 70 Nº 4 elocation e20231358

Resumo: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: This prospective study aimed to provide a comprehensive analysis of the methylation status of two pivotal genes, CDKN2A/p16INK4A (cyclin-dependent kinase inhibitor 2A) and RB1 (retinoblastoma transcriptional corepressor 1), in breast cancer patients. METHODS: Samples were obtained from 15 women diagnosed with breast cancer and who underwent a total mastectomy. DNA was extracted from the tumor, non-tumor tissue, and peripheral blood (circulating cell-free DNA). The methylation pattern of cell-free DNA extracted from blood collected on the day of mastectomy was compared with the methylation pattern of cell-free DNA from blood collected 1 year post-surgery. The methylation analysis was carried out by sodium bisulfite conversion and polymerase chain reaction, followed by electrophoresis. RESULTS: Methylation of CDKN2A/p16INK4A was identified in 13 tumor samples and 12 non-tumor tissue samples. Two patients exhibited CDKN2A/p16INK4A methylation in the cell-free DNA of the first blood collection, while another showed methylation only in the cell-free DNA of the subsequent blood collection. Regarding RB1, 11 tumors and 8 non-tumor tissue samples presented methylation of the gene. CONCLUSION: This study presents a novel approach for monitoring breast cancer patients through the analysis of cell-free DNA methylation. This analysis can detect changes in methylation patterns before any visible sign of cancer appears in breast tissue and could help predict the recurrence of malignant breast tumors. OBJECTIVE genes CDKN2Ap16INK4A CDKNApINKA CDKN2A p16INK4A CDKN A p INK cyclindependent cyclin dependent 2A RB retinoblastoma 1, , 1) METHODS nontumor non circulating cellfree cell free DNA. . DNA) postsurgery. postsurgery post surgery. surgery post-surgery reaction electrophoresis RESULTS collection gene CONCLUSION Ap CDKNA pINKA

https://doi.org/10.1590/1806-9282.20231358

Relationship Between Celiac Disease and Dental Caries in Children and Adolescents: A Systematic Review and Meta-Analysis Adolescents MetaAnalysis Meta Analysis
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Albuquerque, Sylvia Amélia Vasconcelos de

; Moreira, Kelly Maria Silva

; Araújo, Djairo Vinícius Alves de

; França, Glória Maria de

; Nóbrega, Diego Figueiredo

; Costa, Marcelo de Almeida

; Santos, Natanael Barbosa dos

; Imparato, José Carlos Pettorossi

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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2024, Volume 24 elocation e230129

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To assess the relationship between celiac disease and the prevalence of dental caries in children and adolescents and also evaluate if dental enamel defects in celiac children predispose to dental caries. Material and Methods: Searches were performed in the following databases: PubMed, Scopus, Cochrane Library, Latin American and Caribbean Literature on Health Sciences, and OpenGrey. The risk of bias was assessed using the Newcastle-Ottawa Scale. DMFT/dmft and DMFS/dmfs data of observational studies that compared the prevalence of caries between children and adolescents with celiac disease and healthy individuals. Meta-analysis was performed using a random effects model. Heterogeneity between studies was estimated using Cochran’s Q test, and inconsistency was measured using I2 statistics. Results: Of the 121 studies retrieved, 17 were selected, and 12 were included in the meta-analysis. The prevalence of caries in the primary dentition (dmft) did not differ between celiac patients and controls [SMD = -0.35; 95% CI (-0.83; 0.13); p = 0,15; I2 = 89%]. There was also no difference in the prevalence of caries in permanent teeth (DMFT) between groups [SMD = -0.44; 95% CI (-1.02; 0.14); p = 0.14; I2 = 95%]. Conclusion: Celiac disease is not a determinant factor in the development of dental caries in children and adolescents compared to the control group. Objective Methods databases PubMed Scopus Library Sciences OpenGrey NewcastleOttawa Newcastle Ottawa Scale DMFTdmft DMFT dmft DMFSdmfs DMFS dmfs individuals Metaanalysis Meta analysis model Cochrans Cochran s test I statistics Results retrieved 1 selected metaanalysis. metaanalysis meta analysis. meta-analysis (dmft SMD 0.35 035 0 35 -0.35 95 0.83 083 83 (-0.83 0.13 013 13 0.13) 0,15 015 15 89%. 89 89% . 89%] (DMFT 0.44 044 44 -0.44 1.02 102 02 (-1.02 0.14 014 14 0.14) 95%. 95%] Conclusion group 0.3 03 3 -0.3 9 0.8 08 8 (-0.8 0.1 01 0,1 0.4 04 4 -0.4 1.0 10 (-1.0 0. -0. (-0. 0, 1. (-1. -0 (-0 (-1 - (- (

https://doi.org/10.1590/pboci.2024.045

Effects of environmental variability on phytoplankton structure, diversity and biomass at the Brazil-Malvinas Confluence (BMC) structure BrazilMalvinas Brazil Malvinas BMC (BMC
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MOURA-FALCÃO, RAFAEL HENRIQUE DE

; SILVA-CUNHA, MARIA DA GLÓRIA G. DA

; BORGES, GISLAYNE CRISTINA P.

; FERREIRA, LEANDRO C.

; FARIAS, GABRIEL B.

; ALBERGARIA-BARBOSA, ANA CECÍLIA R. DE

; REIS, PEDRO A.

; ARAUJO FILHO, MOACYR C. DE

; MELO, PEDRO AUGUSTO M.C.

Anais da Academia Brasileira de Ciências

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2024, Volume 96 Supl. 2 elocation e20230744

Resumo: En | Texto: En | PDF: En

Abstract The Brazil-Malvinas Confluence (BMC) is a significant biological frontier where distinct currents meet, fostering optimal conditions for phytoplankton development. In this study we tested the hypothesis that eddys promote an increase in phytoplankton biomass at the Brazil-Malvinas Confluence (BMC), altering species diversity. Phytoplankton were collected with Niskin bottles and nutrient concentrations assessed at two depths (Surface and Deep Chlorophyll Maximum Layer – DCML) in areas outside and under the influence of Cold-Core (CCE) and Warm-Core (WCE) Eddies. Environmental variables were determined in situ using a CTD profiler. Four regions were separated based on environmental variables and phytoplankton species, namely, the Brazil Current (BC), Malvinas Current (MC), CCE, and WCE. Species diversity was higher in the eddies. The conditions of the WCE were different from those of the CCE, with low temperature and salinity and high cell density values in the latter. The phylum Bacillariophyta was predominant in terms of species richness in all regions and was responsible for the higher cell density in the MC, while dinoflagellates were dominant in the BC and eddies. Therefore, eddy activity alters the structure, diversity and biomass of the phytoplankton community in the BMC. BrazilMalvinas BMC (BMC meet development BMC, , Surface DCML ColdCore Cold Core CCE (CCE WarmCore Warm (WCE Eddies profiler namely BC, (BC) MC (MC) eddies latter Therefore structure (BC (MC

https://doi.org/10.1590/0001-3765202420230744

RECURSOS EDUCACIONAIS PARA ESTUDANTES COM TRANSTORNO DO ESPECTRO DO AUTISMO (TEA): SÍNTESE DE EVIDÊNCIAS QUALITATIVAS TEA (TEA) (TEA
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Andrade, Aurélio Matos

; Girardi, Juliana da Motta

; Melo, Mayra do Nascimento

; Pereira, Daniella Cristina Rodrigues

; Lima, Maria da Glória

; Amorim, Rivadavio Fernandes Batista de

; Silva, Waldeyr Mendes Cordeiro da

Psicologia Escolar e Educacional

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2024, Volume 28 elocation e259575

Resumo: En Pt Es | Texto: En Pt Es | PDF: En | PDF: Pt | PDF: Es

ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that compromises communication and social skills. This study aimed to analyze the educational resources used by technical and higher education professionals who deal with students with ASD. This review was registered in PROSPERO CRD42020212986 and followed the recommendations of the Standards for Reporting Qualitative Research (SRQR) checklist. The scientific databases used in the search were Medline via PubMed, Embase, Web of Science and Lilacs. Ten articles were selected for the review. The educational resources that stood out along the way were: training in social and organizational skills; educational/professional support and monitoring; technological artifacts for audiovisual interaction; and assessment tools with educational capabilities. It is understood that the improvement of educational resources, emphasizing clear and objective communication, as well as the sociability of classes, becomes essential to promote a more effective and stimulating educational environment for the learning of autistic students. ASD (ASD skills CRD CRD4202021298 SRQR (SRQR checklist PubMed Embase Lilacs educationalprofessional professional monitoring interaction capabilities classes CRD420202129 CRD42020212 CRD4202021 CRD420202 CRD42020 CRD4202 CRD420 CRD42 CRD4

RESUMO O Transtorno do Espectro do Autismo (TEA) é um transtorno do neurodesenvolvimento que compromete a comunicação e as habilidades sociais. Este estudo teve como objetivo analisar os recursos educacionais utilizados por profissionais de nível técnico e superior que lidam com alunos com TEA. Essa revisão foi registrada no PROSPERO CRD42020212986 e seguiu as recomendações da lista de verificação Standards for Reporting Qualitative Research (SRQR). As bases científicas utilizadas na busca foram Medline via PubMed, Embase, Web of Science e Lilacs. Dez artigos foram selecionados para a revisão. Os recursos educacionais que se destacaram ao longo do percurso foram: a formação em competências sociais e organizacionais; apoio e acompanhamento educacional/profissional; artefatos tecnológicos para interação audiovisual; e ferramentas de avaliação com capacidade educacional. Entende-se que a melhoria dos recursos educacionais, enfatizando a comunicação clara e objetiva, bem como a sociabilidade das aulas se torna fundamental para promover um ambiente educacional mais eficaz e estimulante para o aprendizado dos estudantes autistas. TEA (TEA CRD CRD4202021298 SRQR. SRQR . (SRQR) PubMed Embase Lilacs organizacionais educacional/profissional educacionalprofissional profissional audiovisual Entendese Entende objetiva autistas CRD420202129 (SRQR CRD42020212 CRD4202021 CRD420202 CRD42020 CRD4202 CRD420 CRD42 CRD4

RESUMEN El Trastorno del Espectro del Autismo (TEA) es un trastorno del neuro desarrollo que compromete la comunicación y las habilidades sociales. En este estudio se tuvo como objetivo analizar los recursos educacionales utilizados por profesionales de nivel técnico y universitario que lidian con alumnos con TEA. Esta revisión se registró en el PROSPERO CRD42020212986 y siguió las recomendaciones de la lista de verificación Standards for Reporting Qualitative Research (SRQR). Las bases científicas utilizadas en la búsqueda fueron Medline vía PubMed, Embase, Web of Science e Lilacs. Para la revisión, se seleccionaron diez artículos. Los recursos educacionales que se destacaron a lo largo del recorrido fueron la formación en competencias sociales y organizacionales; apoyo y acompañamiento educacional/profesional; artefactos tecnológicos para interacción audiovisual; y herramientas de evaluación con capacidad educacional. Se entiende que el mejoramiento de los recursos educativos, enfatizando la comunicación clara y objetiva, así como la sociabilidad de las clases, se vuelve esencial para promover un ambiente educativo más efectivo y estimulante para el aprendizaje de los estudiantes autistas. TEA (TEA CRD CRD4202021298 SRQR. SRQR . (SRQR) PubMed Embase Lilacs artículos organizacionales educacional/profesional educacionalprofesional educacional profesional audiovisual educativos objetiva clases autistas CRD420202129 (SRQR CRD42020212 CRD4202021 CRD420202 CRD42020 CRD4202 CRD420 CRD42 CRD4

https://doi.org/10.1590/2175-35392024-259575

Homologous equivalence study of immunogenicity after third dose of Covid-19 vaccine (recombinant) with an interval of six months after the second dose, comparing the interval of eight and 12 weeks between the first two doses Covid19 Covid 19 Covid-1 recombinant (recombinant 1 Covid1 Covid-
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Vianna, Clarice Monteiro

; da Silva e Sá, Gloria Regina

; Seid, Maria Vitória Hadland

; Camacho, Luiz Antonio Bastos

; Xavier, Janaína Reis

; da Gama, Vitor Cardoso

; de Castro, Thalita da Matta

; dos Santos, Ewerton Alves Portela

; de Almeida, Camila Dias

; Cruz, Robson Leite de Souza

; Siqueira, Marilda

; Maia, Maria de Lourdes de Sousa

; Ferroco, Clara Lucy de Vasconcellos

; de Araújo, Mia Ferreira

; Tort, Luis Fernando López

; Caetano, Braulia Costa

Memórias do Instituto Oswaldo Cruz

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2024, Volume 119 elocation e240094

Resumo: En | Texto: En | PDF: En

BACKGROUND In response to the coronavirus disease 2019 (Covid-19) pandemic, Brazil authorised the Astra Zeneca/Fiocruz vaccine in January 2021. As the Delta variant emerged in May 2021, interval between vaccine doses was adjusted. By September 2021, the Brazilian National Immunisation Program recommended a booster dose for individuals over 70, and later expanded the recommendation to all adults. OBJECTIVES Assess the equivalence of IgG antibody response against the Covid-19 S protein before and approximately 28 days after the third dose of a Covid-19 recombinant vaccine. Two groups received initial two doses with intervals of eight and 12 weeks. METHODS This is a phase IV clinical study, uncontrolled, non-randomised. The study proposes calculating the ratio of geometric means titres (GMT) 28 days after the third dose, with a target ratio of confidence interval (CI) between 0.77 and 1.3. FINDINGS In the primary endpoint, there was no equivalence between the eight- and 12-week intervals with a slight variation favouring the eight-week group. Post-third dose, both groups showed increases titres at 28 days, three months, six months and 12 months. Both groups responded similarly to Delta and Omicron BA.1, with a more significant increase for Delta. MAIN CONCLUSIONS The study showed strong and consistent immune response in all age groups receiving the Covid-19 recombinant vaccine. Third dose elicited an increase in GMT by at least three times aligned with Ministry of Health strategies emphasising Bio-Manguinhos crucial role in pandemic control in the country. 201 Covid19 Covid 19 (Covid-19 ZenecaFiocruz Zeneca Fiocruz 2021 adjusted 70 adults Covid-1 2 1 weeks uncontrolled nonrandomised. nonrandomised non randomised. randomised non-randomised (GMT CI (CI 077 0 77 0.7 13 3 1.3 endpoint 12week week eightweek group Postthird Post BA1 BA BA.1 BioManguinhos Bio Manguinhos country 20 Covid1 (Covid-1 202 7 Covid- 07 0. 1. BA. (Covid- (Covid

https://doi.org/10.1590/0074-02760240094

Racial inequalities in child vaccination and barriers to vaccination in Brazil among live births in 2017 and 2018: an analysis of a retrospective cohort of the first two years of life 201 2018 20 2
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Boing, Antonio Fernando

; Boing, Alexandra Crispim

; França, Ana Paula

; Moraes, José Cássio de

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 Nº spe2 elocation e20231216

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo Descrever a completude vacinal em tempo oportuno nos primeiros 24 meses de vida no Brasil e os obstáculos para vacinação, testando-se associações com raça/cor da pele materna. Métodos Fez-se coleta de informações sobre os nascidos em 2017 e 2018, constantes no Inquérito Nacional de Cobertura Vacinal. Foram calculados prevalência e intervalos de confiança de 95% de obstáculos à vacinação e completude vacinal em tempo oportuno aos 5 meses, primeiro e segundo ano, segundo raça/cor da pele materna. Empregou-se regressão logística para análise de associações. Resultados Analisaram-se dados de 37.801 crianças. Do total, 7,2% (IC95% 6,3;8,2) dos responsáveis enfrentaram dificuldades para levar seus filhos para vacinação e 23,4% (IC95% 21,7;25,1) das crianças não foram vacinadas, mesmo sendo levadas. Essas proporções foram 75% (IC95% 1,25;2,45) e 97% (IC95% 1,57;2,48) mais elevadas, respectivamente, entre pretas; e 49,9% (IC95% 47,8;51,9) e 61,1% (IC95% 59,2;63,0) das crianças tiveram atraso em alguma vacina até os 5 meses e o primeiro ano, respectivamente. Tais valores foram maiores entre pardas/pretas. Conclusão Há desigualdades raciais nos obstáculos enfrentados e na vacinação no Brasil. 2 testandose testando se raçacor raça cor materna Fezse Fez 201 2018 Vacinal 95 ano Empregouse Empregou Analisaramse Analisaram 37801 37 801 37.80 total 72 7 7,2 IC95% IC95 IC (IC95 6,38,2 6382 6,3 8,2 6 3 8 6,3;8,2 234 23 4 23,4 21,725,1 217251 21,7 25,1 21 25 1 21,7;25,1 vacinadas levadas 75 1,252,45 125245 1,25 2,45 45 1,25;2,45 97 1,572,48 157248 1,57 2,48 57 48 1,57;2,48 elevadas respectivamente pretas 499 49 9 49,9 47,851,9 478519 47,8 51,9 47 51 47,8;51,9 611 61 61,1 59,263,0 592630 59,2 63,0 59 63 0 59,2;63,0 pardaspretas pardas pardas/pretas 20 3780 80 37.8 7, IC9 (IC9 38 6,38, 638 6, 82 8, 6,3;8, 23, 725 21,725, 21725 217 21, 251 25, 21,7;25, 252 1,252,4 12524 125 1,2 245 2,4 1,25;2,4 572 1,572,4 15724 157 1,5 248 1,57;2,4 49, 851 47,851, 47851 478 47, 519 51, 47,8;51, 61, 263 59,263, 59263 592 59, 630 63, 59,2;63, 378 37. (IC 6,38 6,3;8 21,725 2172 21,7;25 1,252, 1252 12 1, 2, 1,25;2, 1,572, 1572 15 1,57;2, 85 47,851 4785 47,8;51 26 59,263 5926 59,2;63 6,3; 21,72 21,7;2 1,252 1,25;2 1,572 1,57;2 47,85 47,8;5 59,26 59,2;6 21,7; 1,25; 1,57; 47,8; 59,2;

ABSTRACT Objective To describe timely vaccination completion and obstacles in the first 24 months of life in Brazil, examining associations with maternal race/skin color. Methods Study participants were 37,801 children born in 2017 and 2018 included in the National Immunization Coverage Survey. We calculated prevalence and 95% confidence intervals for timely vaccine completeness and obstacles at 5, 12 and 24 months of life, according to maternal race/skin color. Associations were analyzed using logistic regression. Results 7.2% (95%CI 6.3;8.2) of mothers faced difficulties in taking their children to be vaccinated, and 23.4% (95%CI 21.7;25.1) were not vaccinated when taken. These proportions were 75% (95%CI 1.25;2.45) and 97% (95%CI 1.57;2.48) higher, respectively, among Black mothers. At least one vaccination was delayed among 49.9% (95%CI 47.8;51.9) and 61.1% (95%CI 59.2;63.0) of children by 5 and 12 months, respectively. These rates were higher among Black/mixed race mothers. Conclusion There are racial inequalities in both the obstacles faced and in vaccination rates in Brazil. 2 Brazil raceskin skin color 37801 37 801 37,80 201 Survey 95 1 regression 72 7 7.2 95%CI 95CI CI 6.38.2 6382 6.3 8.2 6 3 8 6.3;8.2 234 23 4 23.4 21.725.1 217251 21.7 25.1 21 25 21.7;25.1 taken 75 1.252.45 125245 1.25 2.45 45 1.25;2.45 97 1.572.48 157248 1.57 2.48 57 48 1.57;2.48 respectively 499 49 9 49.9 47.851.9 478519 47.8 51.9 47 51 47.8;51.9 611 61 61.1 59.263.0 592630 59.2 63.0 59 63 0 59.2;63.0 Blackmixed mixed 3780 80 37,8 20 7. 38 6.38. 638 6. 82 8. 6.3;8. 23. 725 21.725. 21725 217 21. 251 25. 21.7;25. 252 1.252.4 12524 125 1.2 245 2.4 1.25;2.4 572 1.572.4 15724 157 1.5 248 1.57;2.4 49. 851 47.851. 47851 478 47. 519 51. 47.8;51. 61. 263 59.263. 59263 592 59. 630 63. 59.2;63. 378 37, 6.38 6.3;8 21.725 2172 21.7;25 1.252. 1252 1. 2. 1.25;2. 1.572. 1572 15 1.57;2. 85 47.851 4785 47.8;51 26 59.263 5926 59.2;63 6.3; 21.72 21.7;2 1.252 1.25;2 1.572 1.57;2 47.85 47.8;5 59.26 59.2;6 21.7; 1.25; 1.57; 47.8; 59.2;

resumen está disponible en el texto completo

https://doi.org/10.1590/s2237-96222024v33e20231216.especial2.en

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Boing, Antonio Fernando

; Boing, Alexandra Crispim

; França, Ana Paula

; Moraes, José Cássio de

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

Métricas do periódico
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2024, Volume 33 Nº spe2 elocation e20231216

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

resumen está disponible en el texto completo

https://doi.org/10.1590/s2237-96222024v33e20231216.especial2.en

10.

Description of vaccination coverage and hesitancy obtained by epidemiological survey of children born in 2017-2018, in Belo Horizonte and Sete Lagoas, Minas Gerais, Brazil
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Simões, Taynãna César

; Campos Neto, Orozimbo Henriques

; França, Ana Paula

; Moraes, José Cássio de

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

Métricas do periódico
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- SciELO Analytics

2024, Volume 33 Nº spe2 elocation e20231188

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

resumen está disponible en el texto completo

https://doi.org/10.1590/s2237-96222024v33e20231188.especial2.en

11.

Description of vaccination coverage and hesitancy obtained by epidemiological survey of children born in 2017-2018, in Belo Horizonte and Sete Lagoas, Minas Gerais, Brazil 20172018, 20172018 2017 2018, 2018 2017-2018 Lagoas Gerais 2017201 201 2017-201 201720 20 2017-20 20172 2 2017-2 2017-
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Simões, Taynãna César

; Campos Neto, Orozimbo Henriques

; França, Ana Paula

; Moraes, José Cássio de

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 Nº spe2 elocation e20231188

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo Descrever as coberturas e hesitação das vacinas do calendário básico infantil em Belo Horizonte e Sete Lagoas, Minas Gerais. Métodos Inquéritos epidemiológicos de base populacional realizados de 2020 a 2022, para estimar coberturas vacinais por tipo de imunobiológico e esquema completo (doses válidas e aplicadas) segundo estratos socioeconômicos, e os motivos de hesitação vacinal. Resultados A cobertura global com doses válidas e a hesitação vacinal de pelo menos uma vacina foram, respectivamente, de 50,2% (IC95% 44,1;56,2) e 1,6% (IC95% 0,9;2,7), em Belo Horizonte (n = 1.866), e de 64,9% (IC95% 56,9;72,1) e 1,0% (IC95% 0,3;2,8), em Sete Lagoas (n = 451), com diferenças entre os estratos. O receio de reações graves foi o principal motivo de hesitação vacinal. Conclusão Identificou-se coberturas abaixo do preconizado para a maioria das vacinas. A desinformação deve ser combatida, evitando-se a hesitação vacinal. Há necessidade premente de recuperar as coberturas, considerando acesso ao SUS e disparidades socioeconômicas. Gerais 202 2022 aplicadas socioeconômicos foram respectivamente 502 50 2 50,2 IC95% IC95 IC (IC95 44,156,2 441562 44,1 56,2 44 1 56 44,1;56,2 16 6 1,6 0,92,7, 0927 0,9 2,7 , 0 9 7 0,9;2,7) n 1.866, 1866 1.866 866 1.866) 649 64 64,9 56,972,1 569721 56,9 72,1 72 56,9;72,1 10 1,0 0,32,8, 0328 0,3 2,8 3 8 0,3;2,8) 451, 451 451) Identificouse Identificou se combatida evitandose evitando socioeconômicas 20 5 50, IC9 (IC9 156 44,156, 44156 441 44, 562 56, 4 44,1;56, 1, 92 0,92,7 092 09 0, 27 2, 0,9;2,7 186 1.86 86 64, 972 56,972, 56972 569 721 72, 56,9;72, 32 0,32,8 032 03 28 0,3;2,8 45 (IC 15 44,156 4415 44,1;56 0,92, 0,9;2, 18 1.8 97 56,972 5697 56,9;72 0,32, 0,3;2, 44,15 44,1;5 0,92 0,9;2 1. 56,97 56,9;7 0,32 0,3;2 44,1; 0,9; 56,9; 0,3;

ABSTRACT Objective To describe vaccination coverage and hesitation for the basic children’s schedule in Belo Horizonte and Sete Lagoas, Minas Gerais state, Brazil. Methods Population-based epidemiological surveys performed from 2020 to 2022, which estimated vaccine coverage by type of immunobiological product and full schedule (valid and ministered doses), according to socioeconomic strata; and reasons for vaccination hesitancy. Results Overall coverage with valid doses and vaccination hesitancy for at least one vaccine were, respectively, 50.2% (95%CI 44.1;56.2) and 1.6% (95%CI 0.9;2.7), in Belo Horizonte (n = 1,866), and 64.9% (95%CI 56.9;72.1) and 1.0% (95%CI 0.3;2.8), in Sete Lagoas (n = 451), with differences between socioeconomic strata. Fear of severe reactions was the main reason for vaccination hesitancy. Conclusion Coverage was identified as being below recommended levels for most vaccines. Disinformation should be combated in order to avoid vaccination hesitancy. There is a pressing need to recover coverages, considering public health service access and socioeconomic disparities. childrens children s state Brazil Populationbased Population based 202 2022 doses, , doses) strata were respectively 502 50 2 50.2 95%CI 95CI CI 95 44.156.2 441562 44.1 56.2 44 1 56 44.1;56.2 16 6 1.6 0.92.7, 0927 0.9 2.7 0 9 7 0.9;2.7) n 1,866, 1866 1,866 866 1,866) 649 64 64.9 56.972.1 569721 56.9 72.1 72 56.9;72.1 10 1.0 0.32.8, 0328 0.3 2.8 3 8 0.3;2.8) 451, 451 451) vaccines coverages disparities 20 5 50. 156 44.156. 44156 441 44. 562 56. 4 44.1;56. 1. 92 0.92.7 092 09 0. 27 2. 0.9;2.7 186 1,86 86 64. 972 56.972. 56972 569 721 72. 56.9;72. 32 0.32.8 032 03 28 0.3;2.8 45 15 44.156 4415 44.1;56 0.92. 0.9;2. 18 1,8 97 56.972 5697 56.9;72 0.32. 0.3;2. 44.15 44.1;5 0.92 0.9;2 1, 56.97 56.9;7 0.32 0.3;2 44.1; 0.9; 56.9; 0.3;

resumen está disponible en el texto completo

https://doi.org/10.1590/s2237-96222024v33e20231188.especial2.en

12.

Cognition and obesity in adults with epilepsy
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Tedrus, Glória Maria AS

; Leandro-Merhi, Vania Aparecida

; Rebelo, Rafaella Colicigno

; Silva, Bárbara Nunes da

Nutrición Hospitalaria

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Out 2023, Volume 40 Nº 5 Páginas 1033 - 1040

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Objective: to assess the occurrence of overweight/obesity in patient with epilepsy (PWEs) and to relate it to cognitive aspects and clinical variables. Methodology: the measurements of waist circumference, calf circumference, arm circumference, and the body mass index were related to the scores of the Mini-Mental State Examination and the Brief Cognitive Battery-Edu, as well as to the clinical variables of 164 PWEs, with a significance level of p < 0.05. Data were compared to a similar control group (CG) comprising 71 cases. Linear and multiple logistic regression models were used to assess factors related to cognitive aspects. Results: the mean age of the PWEs was 49.8 ± 16.6 years with a mean length of epilepsy of 22 ± 15.9 years. Overweight/obesity occurred in 106 (64.6 %) PWEs and in 42 (59.1 %) CG subjects. The PWEs had a worse performance in several cognitive functions when compared to CG subjects. In the PWEs, overweight/obesity was associated with lower educational level, older age, and cognitive impairment. Greater waist circumference, overweight, age at the first seizure, and use of polytherapy with antiseizure medications were predictive factors of memory impairment in multiple linear regression. Greater arm and calf circumference values were associated with better performance in several cognitive areas. Conclusion: the occurrence of overweight/obesity in PWEs and CG subjects was high. Cognitive impairment occurred in a high number of PWEs and was associated with overweight, greater waist circumference values, and clinical aspects of epilepsy. Better cognitive performance was associated with greater arm and calf circumference.

Resumen Objetivo: evaluar la ocurrencia de sobrepeso/obesidad en pacientes con epilepsia y relacionarla con aspectos cognitivos y variables clínicas. Metodología: las medidas de circunferencia de cintura, circunferencia de pantorrilla, circunferencia de brazo e índice de masa corporal se relacionaron con los puntajes del Mini-Mental State Exam y de la Batería Cognitiva Breve-Edu, así como con las variables clínicas de 164 pacientes con epilepsia, con un nivel de significación de p < 0,05. Los datos se compararon con un grupo de control similar (GC) compuesto por 71 casos. Se utilizaron modelos de regresión logística lineal y múltiple para evaluar factores relacionados con aspectos cognitivos. Resultados: la edad media de las pacientes con epilepsia fue de 49,8 ± 16,6 años con una duración media de la epilepsia de 22 ± 15,9 años. Presentaron sobrepeso/obesidad 106 (64,6 %) pacientes con epilepsia y 42 (59,1 %) sujetos del GC. Los pacientes con epilepsia tuvieron un peor desempeño en varias funciones cognitivas en comparación con los sujetos del GC. En las pacientes con epilepsia, el sobrepeso/obesidad se asoció con menor nivel educativo, mayor edad y deterioro cognitivo. La mayor circunferencia de la cintura, el sobrepeso, la edad de la primera convulsión y el uso de politerapia con medicamentos anticonvulsivos fueron factores predictivos del deterioro de la memoria en la regresión lineal múltiple. Los valores mayores de circunferencia del brazo y la pantorrilla se asociaron con un mejor rendimiento en varias áreas cognitivas. Conclusión: la incidencia de sobrepeso/obesidad en sujetos pacientes con epilepsia y GC fue alta. El deterioro cognitivo ocurrió en un alto número de pacientes con epilepsia y se asoció con sobrepeso, mayores valores de circunferencia de la cintura y aspectos clínicos de la epilepsia. Un mejor rendimiento cognitivo se asoció con una mayor circunferencia del brazo y la pantorrilla.

https://doi.org/10.20960/nh.04421

13.

Tendência temporal da prevalência e mortalidade infantil das anomalias congênitas no Brasil, de 2001 a 2018 Brasil 200 201 20 2
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Fernandes, Qeren Hapuk R. Ferreira

; Paixão, Enny S.

; Costa, Maria da Conceição N.

; Teixeira, Maria Glória

; Rios, Juliana Darbra Cruz

; Santo, Keila da Silva Goes Di

; Barreto, Mauricio L.

; Acosta, Angelina Xavier

Ciência & Saúde Coletiva

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Abr 2023, Volume 28 Nº 4 Páginas 969 - 979

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Congenital anomalies (CA) are a relevant problem for global public health, affecting about 3% to 6% of newborns worldwide. In Brazil, these are the second main cause of infant mortality. Thus, extensive studies are needed to demonstrate the impact of these anomalies on births and deaths. The present study describes the temporal trends of prevalence and infant mortality due to CA among live births in Brazil and regions, from 2001 to 2018, using the related data between the Live Birth Information System (SINASC, acronym in Portuguese) and the Mortality Information System (SIM, acronym in Portuguese). The prevalence and infant mortality due to CA has increased in Brazil and in most regions, especially in the Northeast and North. CAs in the musculoskeletal system were the most frequent at birth (29.8/10,000 live births), followed by those in the circulatory system (12.7/10,000 live births), which represented the primary cause of death in this group. The applied linkage technique made it possible to correct the national prevalence of CA by 17.9% during the analyzed period, after retrieving the anomalies reported in SIM, thereby proving to be a good tool to improve the quality of information on anomalies in Brazil. (CA health 3 6 worldwide Thus deaths regions 200 2018 SINASC, SINASC (SINASC Portuguese SIM (SIM Portuguese. . North 29.8/10,000 29810000 29 8 10 000 (29.8/10,00 births, , births) 12.7/10,000 12710000 12 7 (12.7/10,00 group 179 17 9 17.9 period 20 201 29.8/10,00 2981000 2 1 00 (29.8/10,0 12.7/10,00 1271000 (12.7/10,0 17. 29.8/10,0 298100 0 (29.8/10, 12.7/10,0 127100 (12.7/10, 29.8/10, 29810 (29.8/10 12.7/10, 12710 (12.7/10 29.8/10 2981 (29.8/1 12.7/10 1271 (12.7/1 29.8/1 298 (29.8/ 12.7/1 127 (12.7/ 29.8/ (29.8 12.7/ (12.7 29.8 (29. 12.7 (12. 29. (29 12. (12 (2 (1 (

Resumo As anomalias congênitas (AC) configuram um relevante problema para a saúde pública global, afetando em média de 3% a 6% dos recém-nascidos em todo o mundo. No Brasil, ocupam a segunda posição entre os principais grupos de causas de óbito infantil. Assim, estudos amplos são necessários para mostrar o impacto das AC na saúde infantil. O presente estudo descreve a tendência temporal da prevalência e da mortalidade infantil por AC entre nascidos vivos (NV) no Brasil e em suas cinco regiões de 2001 a 2018, utilizando dados vinculados entre as bases de dados do Sistema de Informações sobre Nascidos Vivos (SINASC) e do Sistema de Informações sobre Mortalidade (SIM). A prevalência e mortalidade infantil por AC mostrou-se crescente no Brasil na maioria das regiões, principalmente no Norte e no Nordeste. Aquelas do aparelho osteomuscular foram as mais prevalentes ao nascimento (29,8/10.000 NV); as do aparelho circulatório passaram para a segunda posição (12,7/10.000 NV) após a vinculação das bases e representam a primeira causa de morte desse grupo. A técnica de vinculação de dados aplicada corrigiu a prevalência nacional das AC em 17,9% no período analisado, após serem recuperadas as AC notificadas no SIM, mostrando ser uma boa ferramenta para melhorar a qualidade das informações das AC. (AC global 3 6 recémnascidos recém mundo Assim NV (NV 200 2018 SINASC (SINASC SIM. SIM . (SIM) mostrouse mostrou se Nordeste 29,8/10.000 29810000 29 8 10 000 (29,8/10.00 12,7/10.000 12710000 12 7 (12,7/10.00 grupo 179 17 9 17,9 analisado 20 201 (SIM 29,8/10.00 2981000 2 1 00 (29,8/10.0 12,7/10.00 1271000 (12,7/10.0 17, 29,8/10.0 298100 0 (29,8/10. 12,7/10.0 127100 (12,7/10. 29,8/10. 29810 (29,8/10 12,7/10. 12710 (12,7/10 29,8/10 2981 (29,8/1 12,7/10 1271 (12,7/1 29,8/1 298 (29,8/ 12,7/1 127 (12,7/ 29,8/ (29,8 12,7/ (12,7 29,8 (29, 12,7 (12, 29, (29 12, (12 (2 (1 (

https://doi.org/10.1590/1413-81232023284.13912022

14.

EGFR, VEGF, and angiogenesis promote the development of lipoma in the oral cavity EGFR VEGF
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Silva, Weslay Rodrigues da

; Pires, Hévila de Figueiredo

; França, Glória Maria de

; Freitas, Roseana de Almeida

; Morais, Hannah Gil de Farias

; Galvão, Hébel Cavalcanti

Brazilian Dental Journal

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Mar 2023, Volume 34 Nº 2 Páginas 113 - 121

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract This study aimed to detect, quantify and compare the immunohistochemical expression of EGFR and VEGF and microvessel count (MVC) in oral lipomas, and to correlate the findings with clinical and morphological characteristics of the cases studied. The sample consisted of 54 oral lipomas (33 classic and 21 non-classic) and 23 normal adipose tissue specimens. Cytoplasmic and/or nuclear immunohistochemical staining of EGFR and VEGF was analyzed. The angiogenic index was determined by MVC. Cells were counted using the Image J® software. The Statistical Package for the Social Sciences was used for data analysis, adopting a level of significance of 5% for all statistical tests. A statistically significant difference in EGFR immunoexpression (p=0.047), especially, between classic lipomas and normal adipose tissue. There was a significant difference in MVC between non-classic lipomas and normal adipose tissue (p=0.022). In non-classic lipomas, only VEGF immunoexpression showed a significant moderate positive correlation (r=0.607, p=0.01) with MVC. In classic lipomas, the number of EGFR-immunostained adipocytes was directly proportional to the number of VEGF-positive cells, demonstrating a significant moderate positive correlation (r=0.566, p=0.005). The results suggest that EGFR, VEGF, and angiogenesis participate in the development of oral lipomas but are not primarily involved in the growth of these tumors. detect (MVC studied 5 33 (3 2 nonclassic non specimens andor or analyzed J software analysis tests p=0.047, p0047 p p=0.047 , 0 047 (p=0.047) especially p=0.022. p0022 p=0.022 . 022 (p=0.022) r=0.607, r0607 r 607 (r=0.607 p=0.01 p001 01 EGFRimmunostained immunostained VEGFpositive cells r=0.566, r0566 566 (r=0.566 p=0.005. p0005 p=0.005 005 p=0.005) tumors 3 ( p004 p=0.04 04 (p=0.047 p002 p=0.02 02 (p=0.022 r=0.607 r060 60 (r=0.60 p=0.0 p00 r=0.566 r056 56 (r=0.56 p000 p=0.00 00 (p=0.04 (p=0.02 r=0.60 r06 6 (r=0.6 p=0. p0 r=0.56 r05 (r=0.5 (p=0.0 r=0.6 r0 (r=0. p=0 r=0.5 (p=0. r=0. (r=0 p= (p=0 r=0 (r= (p= r= (r (p

Resumo Lipomas são as neoplasias mesenquimais benignas mais comuns, no entanto sua etiopatogenia ainda permanece desconhecida. Dessa forma, essa pesquisa teve como objetivo detectar, quantificar e comparar a expressão imunoistoquímica do EGFR, VEGF e contagem microvascular (MVC) dos lipomas orais, relacionando-os com as características clínicas e morfológicas dos casos estudados. A amostra foi composta por 54 lipomas orais (33 clássicos e 21 não clássicos) e 23 casos de tecido adiposo normal. A análise da expressão imunoistoquímica de EGFR e VEGF foi fundamentada na marcação citoplasmática e/ou nuclear. O índice angiogênico foi avaliado por meio da MVC. A contagem de células foi realizada utilizando software IMAGE J®. Os dados obtidos foram analisados no software Statistical Package for Social Science. O nível se significância de 5% foi adotado para os testes estatístico. A análise da imunoexpressão das proteínas revelou para o EGFR diferença estatisticamente significativa (p=0,041) entre o lipoma clássico e o tecido adiposo normal. Houve diferença significativa na MVC entre lipomas não clássicos e tecido adiposo normal (p=0,022). Nos lipomas não clássicos, apenas a imunoexpressão de VEGF apresentou correlação do tipo moderada, positiva e significativa (r=0,607; p=0,010) em relação a MVC. Ademais, nos lipomas clássicos foi percebido que os adipócitos imunomarcados para EGFR estiveram diretamente proporcionais a imunoexpressão de VEGF, apresentando correlação do tipo moderada, positiva e estatisticamente significativa (r=0,566; p = 0,005). Com base nos resultados, pode-se sugerir que o EGFR, VEGFR e MCV participam do desenvolvimento nos lipomas orais, contudo, não estão primariamente envolvidos no crescimento tumoral dessas neoplasias. comuns desconhecida forma detectar (MVC relacionandoos relacionando estudados 5 33 (3 2 eou ou nuclear J J® Science estatístico p=0,041 p0041 0 041 (p=0,041 p=0,022. p0022 p=0,022 . 022 (p=0,022) moderada r=0,607 r0607 r 607 (r=0,607 p=0,010 p0010 010 Ademais r=0,566 r0566 566 (r=0,566 0,005. 0005 0,005 005 0,005) resultados podese pode contudo 3 ( p=0,04 p004 04 (p=0,04 p002 p=0,02 02 (p=0,022 r=0,60 r060 60 (r=0,60 p=0,01 p001 01 r=0,56 r056 56 (r=0,56 000 0,00 00 p=0,0 p00 (p=0,0 (p=0,02 r=0,6 r06 6 (r=0,6 r=0,5 r05 (r=0,5 0,0 p=0, p0 (p=0, r=0, r0 (r=0, 0, p=0 (p=0 r=0 (r=0 p= (p= r= (r= (p (r

https://doi.org/10.1590/0103-6440202305117

15.

Epstein-Barr virus in gastric cancer and association with 30 bp del-latent membrane protein 1 polymorphism EpsteinBarr Epstein Barr 3 dellatent del latent
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Santos, Emília Rosaria Carvalho dos

; Silva, Marcelo Soares da Mota e

; Canedo, Nathalie Henriques Silva

; Gaui, Maria de Fatima Dias

; Britto, Álvaro Luiz Vieira Lubambo de

; Silva, William Marco Vicente da

; Carvalho, Maria da Glória da Costa

; Bravo Neto, Guilherme Pinto

Revista da Associação Médica Brasileira

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2023, Volume 69 Nº 5 elocation e20221571

Resumo: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: This study aimed to determine the frequencies of Epstein-Barr virus, types 1 and 2 infection, and 30 bp del-latent membrane protein 1 viral polymorphism in gastric adenocarcinomas, as well as to investigate the association between Epstein-Barr virus infection and tumor location, type, and the patient's sex. METHODS: Samples were collected from 38 patients treated at a university hospital in Rio de Janeiro, Brazil. Epstein-Barr virus detection and genotyping were performed by polymerase chain reaction, followed by polyacrylamide gel electrophoresis and staining by the silver nitrate method. RESULTS: Overall, 68.4% of patients had Epstein-Barr virus-positive tumors. Of these, 65.4% presented infection by Epstein-Barr virus type 1, 23.1% by Epstein-Barr virus type 2, and 11.5% had coinfection with types 1 and 2. The 30 bp del-latent membrane protein 1 polymorphism was found in 42.3% of Epstein-Barr virus-positive tumors, 23.1% had the wild-type virus, and 23.1% had the wild-type and the polymorphism concomitantly. In 11.5% of Epstein-Barr virus-positive tumors, it was impossible to determine whether there was polymorphism or not. Tumor location in the antrum (22 of 38) and diffuse type (27 of 38) were predominant. There was no significant difference in Epstein-Barr virus infection or the 30 bp del-latent membrane protein 1 polymorphism between men and women. CONCLUSION: Epstein-Barr virus infection was found in 68.4% of tumors investigated in this study. To the best of our knowledge, this is the first article showing the coinfection of Epstein-Barr virus types 1 and 2 in gastric carcinoma in Brazil. OBJECTIVE EpsteinBarr Epstein Barr 3 dellatent del latent adenocarcinomas patient s sex METHODS Janeiro Brazil reaction method RESULTS Overall 684 68 4 68.4 viruspositive positive these 654 65 65.4 231 23 23.1 115 11 5 11.5 423 42 42.3 wildtype wild concomitantly not 22 (2 27 predominant women CONCLUSION knowledge 6 68. 65. 23. 11. 42. (

https://doi.org/10.1590/1806-9282.20221571

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